submucous plexus

Summary

Summary: One of two ganglionated neural networks which together form the enteric nervous system. The submucous (Meissner's) plexus is in the connective tissue of the submucosa. Its neurons innervate the epithelium, blood vessels, endocrine cells, other submucosal ganglia, and myenteric ganglia, and play an important role in regulating ion and water transport. (From FASEB J 1989;3:127-38)

Top Publications

  1. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
  2. ncbi Immunohistochemical analysis of neuron types in the mouse small intestine
    Zheng Dong Qu
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville, Victoria, 3010, Australia
    Cell Tissue Res 334:147-61. 2008
  3. ncbi Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans
    J P Timmermans
    Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium
    Anat Rec 262:71-8. 2001
  4. ncbi Classes of enteric nerve cells in the guinea-pig small intestine
    S J Brookes
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia 5001
    Anat Rec 262:58-70. 2001
  5. ncbi Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease
    J Schneider
    Department of General Surgery, Eberhard-Karls University, Tuebingen, Germany
    Neurogastroenterol Motil 13:255-64. 2001
  6. ncbi Two submucosal nerve plexus in human intestines
    Axel Brehmer
    Institute of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Histochem Cell Biol 133:149-61. 2010
  7. ncbi Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
  8. pmc ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    R L Monro
    Department of Physiology, University of Melbourne, Parkville 3010, Victoria, Australia
    J Physiol 556:571-84. 2004
  9. pmc A non-adrenergic, non-cholinergic slow inhibitory post-synaptic potential in neurones of the guinea-pig submucous plexus
    S Mihara
    Neuropharmacology Laboratory, Massachusetts Institute of Technology, Cambridge 02139
    J Physiol 390:357-65. 1987
  10. ncbi Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid
    Jacqueline Nelisis Zanoni
    Department of Morphophysiological Sciences, Universidade Estadual de Maringa, Brasil
    Arq Neuropsiquiatr 60:32-37. 2002

Research Grants

  1. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
  2. OPIATE ACTIONS AND DEPENDENCE--SINGLE NEURON STUDIES
    R North; Fiscal Year: 1993
  3. Enteric Nervous System 2003
    Keith Sharkey; Fiscal Year: 2003
  4. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010

Detail Information

Publications189 found, 100 shown here

  1. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
    ..dye di-8-ANEPPS to monitor directly membrane potential changes and thereby neuronal excitability in the human submucous plexus from surgical specimens of 110 patients (2137 neurones, 273 ganglia)...
  2. ncbi Immunohistochemical analysis of neuron types in the mouse small intestine
    Zheng Dong Qu
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville, Victoria, 3010, Australia
    Cell Tissue Res 334:147-61. 2008
    ..Calretinin immunoreactivity also occurred in a proportion of Type II neurons. Thus, over 90% of neurons in the myenteric plexus of the mouse small intestine can be currently identified by their neurochemistry and shape...
  3. ncbi Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans
    J P Timmermans
    Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium
    Anat Rec 262:71-8. 2001
    ..that the close and exclusive association, which has been assumed so far between the efferent pathways of the submucous plexus and regulation of intestinal secretion/absorption on the one hand and between the myenteric plexus and ..
  4. ncbi Classes of enteric nerve cells in the guinea-pig small intestine
    S J Brookes
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia 5001
    Anat Rec 262:58-70. 2001
    ..This provides a firm anatomical foundation for the systematic analysis of how the enteric nervous system normally functions and how it goes wrong in various clinically important disorders...
  5. ncbi Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease
    J Schneider
    Department of General Surgery, Eberhard-Karls University, Tuebingen, Germany
    Neurogastroenterol Motil 13:255-64. 2001
    ..Thickened CGRP-fibres occurred in CD. We identified neurochemically distinct populations in the human submucous plexus. The increase in the VIP/- population, extensive colocalization of ChAT and NOS and hypertrophied CGRP fibres ..
  6. ncbi Two submucosal nerve plexus in human intestines
    Axel Brehmer
    Institute of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Histochem Cell Biol 133:149-61. 2010
    ..For use of eponyms for two different submucosal plexus, the names of Meissner (inner) and Schabadasch (outer) are historically justified...
  7. ncbi Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
    ..Recently, the neural 5-HT3 receptor received a lot of attention as a possible target in functional bowel diseases. Yet, the 5-HT3 receptor-mediated changes in properties of human enteric neurons is unknown...
  8. pmc ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    R L Monro
    Department of Physiology, University of Melbourne, Parkville 3010, Victoria, Australia
    J Physiol 556:571-84. 2004
    ..aimed to identify neurotransmitters responsible for non-cholinergic excitatory synaptic transmission in the submucous plexus of the guinea pig ileum. Intracellular recordings were made from secretomotor and vasodilator neurones...
  9. pmc A non-adrenergic, non-cholinergic slow inhibitory post-synaptic potential in neurones of the guinea-pig submucous plexus
    S Mihara
    Neuropharmacology Laboratory, Massachusetts Institute of Technology, Cambridge 02139
    J Physiol 390:357-65. 1987
    1. Intracellular recordings were made from neurones in the submucous plexus of guinea-pig ileum and caecum. The responses to electrical stimulation of fibre strands entering the nodes of the plexus were studied. 2...
  10. ncbi Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid
    Jacqueline Nelisis Zanoni
    Department of Morphophysiological Sciences, Universidade Estadual de Maringa, Brasil
    Arq Neuropsiquiatr 60:32-37. 2002
    ..ascorbic acid (AA) supplementation on the neurons that produce the vasoactive intestinal peptide (VIP) in the submucous plexus of the ileum of rat, four months after the induction of experimental diabetes mellitus with streptozotocin...
  11. ncbi Activity of protease-activated receptors in the human submucous plexus
    Kerstin Mueller
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 141:2088-2097.e1. 2011
    ..Studies in several animal models indicate the involvement of neural PARs. We studied the actions of different PAR-activating peptides (AP) in the human submucous plexus and performed comparative studies in guinea pig submucous neurons.
  12. pmc 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    Jaime Pei Pei Foong
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 298:G384-94. 2010
    Vasoactive intestinal peptide (VIP) immunoreactive neurons are important secretomotor neurons in the submucous plexus. They are the only submucosal neurons to receive inhibitory inputs and exhibit both noradrenergic and nonadrenergic ..
  13. ncbi Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum
    David E Reed
    Gastrointestinal Diseases Research Unit, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G608-14. 2007
    ..This pathway projects in parallel with motor and vasodilator reflexes, and this common pathway may enable coordination of intestinal secretion, blood flow, and motility...
  14. ncbi Expression of Tie-2 in human peripheral and autonomic nervous system
    S Poncet
    University of Lausanne, Institute of Pathology, CHUV, Lausanne, Switzerland
    Neuropathol Appl Neurobiol 29:361-9. 2003
    ..Thus, attempts to disrupt the tumour vessels by manipulation of the Tie-2 system in tumours may result in side-effects in peripheral nerves...
  15. ncbi Expression of Notch1 and Jagged2 in the enteric nervous system
    Guy R Sander
    Child Health Research Institute, Womens and Childrens Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Histochem Cytochem 51:969-72. 2003
    ..We propose that Notch1 and Jagged2 have a continuing role in the maintenance and function of neuronal cells in the adult enteric nervous system...
  16. ncbi Neuromuscular changes in a rat model of colitis
    Mariona Aulí
    Department of Cell Biology, Physiology and Immunology, Veterinary Faculty, Universitat Autonoma de Barcelona, Spain
    Auton Neurosci 141:10-21. 2008
    ..T. spiralis-induced colitis causes profound neuromuscular adaptations. The reduction in NOS neurons appears to underlie changes in motility...
  17. pmc Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons
    David E Reed
    Gastrointestinal Diseases Research Unit, Queen s University, Kingston, Ontario, Canada
    J Physiol 547:531-42. 2003
    ..This signalling pathway between immune cells and neurons is a previously unrecognized mechanism that could contribute to chronic alterations in visceral function...
  18. ncbi Morphology and distribution of nitric oxide synthase-, neurokinin-1 receptor-, calretinin-, calbindin-, and neurofilament-M-immunoreactive neurons in the myenteric and submucosal plexuses of the rat small intestine
    Ayman I Sayegh
    Gastroenterology and Imaging Laboratories, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:209-16. 2003
    ..The distribution of these phenotypic markers may assist future work that elucidates the functional activities of these enteric neurons such as control of intestinal motility and adaptation to the entry of gastric contents...
  19. ncbi Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development
    A B M da Silveira
    Research Center Rene Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    Parasitology 135:1337-42. 2008
    ..We believe that this increased regeneration can be interpreted as an accentuated neuronal plasticity that may be a response of the ENS to avoid megacolon propagation to the entire organ and maintain the colon functional innervation...
  20. ncbi An immunohistochemical study of the organization of ganglia and nerve fibres in the mucosa of the porcine intestine
    O B Balemba
    Department of Veterinary Anatomy, Sokoine University of Agriculture, Morogoro, Tanzania, Denmark
    Anat Histol Embryol 31:237-46. 2002
    ....
  21. ncbi Primary afferent neurons intrinsic to the guinea-pig intestine, like primary afferent neurons of spinal and cranial sensory ganglia, bind the lectin, IB4
    Anderson Hind
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Cell Tissue Res 321:151-7. 2005
    ..Strongly reactive neurons are absent from the gastric corpus. Thus, IB4 binding reveals primary afferent neurons with similar morphologies, patterns of binding and physiological roles in enteric, dorsal root and trigeminal ganglia...
  22. ncbi The tight junction component protein, claudin-4, is expressed by enteric neurons in the rat distal colon
    Shin Ichiro Karaki
    Laboratory of Physiology, Institute for Environmental Sciences, and Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurosci Lett 428:88-92. 2007
    ..In conclusion, the present study clearly shows that claudin-4 is expressed by enteric neurons. This is the first evidence that the neuron itself expresses the TJ component protein, claudin-4, in the nervous system...
  23. ncbi Expression and distribution of TTX-sensitive sodium channel alpha subunits in the enteric nervous system
    Aaron C Bartoo
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Program in Neuroscience, Washington State University, Pullman, Washington 99164 6520, USA
    J Comp Neurol 486:117-31. 2005
    ..These data suggest that Na(v)1.1 may not be highly expressed in the ENS, but that Na(v)1.2, Na(v)1.3, and Na(v)1.6, and possibly Na(v)1.7, have broadly important and distinct functions in the ENS...
  24. ncbi Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis
    Alan E Lomax
    Gastrointestinal Diseases Research Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G482-91. 2007
    ..In conclusion, sustained alterations in enteric neural signaling occur following the resolution of colitis, which are accompanied by functional changes in the absence of active inflammation...
  25. ncbi Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system
    Sumei Liu
    Department of Physiology and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210 1218, USA
    J Comp Neurol 481:284-98. 2005
    ..Actions on enteric neurons might underlie the neural mechanisms by which stress-related release of CRF in the periphery alters intestinal propulsive motor function, mucosal secretion, and barrier functions...
  26. ncbi L-aspartate-immunoreactive neurons in the rat enteric nervous system
    Masato Nagahama
    Department of Anatomy II, Mie University School of Medicine, 2 174 Edobashi, 514 0001, Tsu, Mie, Japan
    Cell Tissue Res 318:483-92. 2004
    ..The presence of enteric L-Asp-immunoreactive neurons provides strong support for the proposal that L-Asp is a neuromodulator in the rat ENS...
  27. ncbi The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis
    V Remorgida
    Department of Obstetrics and Gynaecology, Department of General Surgery and Transplant, San Martino Hospital, University of Genoa, Largo R Benzi 1, 16132 Genoa, Italy
    Hum Reprod 20:264-71. 2005
    ..Our aim was to investigate the relationships between gastrointestinal symptoms and histological findings in women with bowel endometriosis...
  28. ncbi Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep
    Roberto Chiocchetti
    Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy
    Cell Tissue Res 318:289-303. 2004
    ..Thus, CALB is a marker of most Dogiel type II neurons in the sheep but is not confined to Dogiel II neurons. CGRP is a more selective marker of Dogiel type II neurons, being only found in this neuron type...
  29. ncbi Histological studies on Hirschsprung's disease and its allied disorders in childhood
    Ryouichi Tomita
    First Department of Surgery, Nihon University School of Medicine, Japan
    Hepatogastroenterology 51:1042-4. 2004
    ....
  30. ncbi Identification and localization of estrogen receptor alpha- and beta-positive cells in adult male and female mouse intestine at various estrogen levels
    Naoko Kawano
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Histochem Cell Biol 121:399-405. 2004
    ..Our results indicate that estrogen and estrogenic compounds may exert their actions on the intestine in two ways; one is through interstitial macrophages and the other is through intestinal neurons...
  31. ncbi Rectal biopsy in the diagnosis of neuronal intranuclear hyaline inclusion disease
    Romana Kulikova-Schupak
    Division of Pediatric Neurology, Columbia University, New York, New York, USA
    J Child Neurol 19:59-62. 2004
    ..Rectal biopsies should be considered in children presenting with otherwise unexplained multisystem degeneration, particularly in the presence of both upper and lower motoneuron signs accompanied by behavioral problems...
  32. ncbi Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal
    Yutaka Okishio
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    J Smooth Muscle Res 41:163-74. 2005
    ..It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum...
  33. ncbi Mesenteric transection decreases expression of interstitial cells of Cajal in an experimental model
    M Nishimura
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Surg 94:483-90. 2007
    ..The aim of this study was to examine the number of interstitial cells of Cajal (ICCs) and ganglion cells in the distal colon partially denervated by mesenteric transection in a rat model...
  34. ncbi Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin
    Zhenghua Xiang
    Department of Biochemistry and Molecular Biology, Second Military Medical University, 200433, Shanghai, People s Republic of China
    Histochem Cell Biol 124:379-90. 2005
    ....
  35. pmc Aquaporin-4 water channels in enteric neurons
    Mia M Thi
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    J Neurosci Res 86:448-56. 2008
    ..It is known that submucosal neurons control transport processes in the intestinal mucosa, and the high percentage of aquaporin-4-positive submucosal neurons suggests that aquaporin-4 contributes to this function...
  36. ncbi The development of colon innervation in trisomy 16 mice and Hirschsprung's disease
    J C Li
    Department of Lymphology, Zhejiang University Medical School, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 7:16-21. 2001
    ..To study the colon innervation of trisomy 16 mouse, an animal model for Down's syndrome, and the expression of protein gene product 9.5 (PGP 9.5) in the stenosed segment of colon in Hirschsprung's disease (HD)...
  37. ncbi Chemical coding and electrophysiology of enteric neurons expressing neurofilament 145 in guinea pig gastrointestinal tract
    Hong Zhen Hu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    J Comp Neurol 442:189-203. 2002
    ..Absence of NF145 from ganglion cells in the submucosal plexus is an example of differences between myenteric and submucosal components of the enteric nervous system...
  38. ncbi Neuronal distribution and subcellular localization of HCNP-like immunoreactivity in rat small intestine
    E Katada
    Second Department of Internal Medicine, Nagoya City University School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Neurocytol 29:199-207. 2000
    ....
  39. ncbi Neuronal nitric oxide synthase activity is increased during granulomatous inflammation in the colon and caecum of pigs infected with Schistosoma japonicum
    O B Balemba
    Department of Veterinary Anatomy, Sokoine University of Agriculture, Morogoro, Tanzania
    Auton Neurosci 99:1-12. 2002
    ..a significant increase in the nerve cell body density of nNOS immunoreactive nerve cell bodies in the inner submucous plexus, outer submucous plexus and in the myenteric plexus...
  40. ncbi Evidence supporting presence of two pacemakers in rat colon
    L Plujà
    Department of Cell Biology, Physiology, and Immunology, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Catalunya, Spain
    Am J Physiol Gastrointest Liver Physiol 281:G255-66. 2001
    ..This is the first report showing consistent slow wave activity in the rodent colon...
  41. ncbi P2X(7) receptors in the enteric nervous system of guinea-pig small intestine
    H Z Hu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio 43210-1218, USA
    J Comp Neurol 440:299-310. 2001
    ..The mucosa, submucosal blood vessels, and the circular muscle coat also showed P2X(7) receptor immunoreactivity...
  42. ncbi Localisation and neural control of the release of calcitonin gene-related peptide (CGRP) from the isolated perfused porcine ileum
    T N Rasmussen
    Department of Surgical Gastroenterology C, Rigshospitalet and Departments of Medical Physiology and Anatomy B, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Regul Pept 98:137-43. 2001
    ..The stimulatory effect of capsaicin suggests that CGRP is also released from extrinsic sensory neurons...
  43. ncbi Distribution of enkephalin-like immunoreactivity in the cat digestive tract
    D Bagnol
    Université d Aix Marseille III, Faculte des Sciences et Techniques de Saint Jerome, France
    J Auton Nerv Syst 64:1-11. 1997
    ..immunoreactivity was detected in the cell bodies of numerous myenteric plexus neurons but those of only a few submucous plexus neurons...
  44. pmc Purinergic receptors and gastrointestinal secretomotor function
    Fievos Leontiou Christofi
    Department of Anesthesiology, The Ohio State University, Columbus, OH, 43210, USA
    Purinergic Signal 4:213-36. 2008
    ..among other mediators) and initiates local reflexes by activating intrinsic primary afferent neurons of the submucous plexus. Signals are conveyed to interneurons or secretomotor neurons to stimulate chloride and fluid secretion...
  45. ncbi Control systems of gastrointestinal motility are immature at birth in dogs
    E E Daniel
    Department of Biomedical Sciences, Health Sciences, McMaster University, 1200 Main St W, Hamilton L8N 3Z5, ON, Canada
    Neurogastroenterol Motil 11:375-92. 1999
    ..Ganglia were present where expected in the Myp and submucous plexus (SMP)...
  46. ncbi Distribution of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) nerve structures in the porcine large intestine
    Slawomir Gonkowski
    Division of Clinical Physiology, Department of Functional Morphology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10 957 Olsztyn Kortowo, Poland
    Acta Vet Hung 57:509-20. 2009
    ..studied by immunohistochemistry in the circular muscle layer, myenteric (MP), outer submucous (OSP) and inner submucous plexus (ISP) as well as in the mucosal layer of six regions of the large bowel: caecum, centripetal and centrifugal ..
  47. ncbi [Enzyme histochemical diagnosis of gastrointestinal motility disorders. A laboratory guide]
    E Bruder
    Institut fur Pathologie, Universitatsspital Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
    Pathologe 28:93-100. 2007
    ..succinic dehydrogenase and nitroxide synthase selectively demonstrate the nerve cells of the myenteric and submucous plexus. These enzyme histochemical techniques require fresh, native tissue...
  48. ncbi Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system
    Norbert Braun
    Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Strasse 9, D 60439 Frankfurt am Main, Germany
    Glia 45:124-32. 2004
    ..ganglia, and with the enteric glia surrounding the cell bodies of ganglionic neurons of the myenteric and the submucous plexus. In contrast to NTPDase1, NTPDase2 preferentially hydrolyzes nucleoside triphosphates over nucleoside ..
  49. pmc mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum
    Jaime Pei Pei Foong
    Department of Physiology, University of Melbourne Parkville, Australia
    Front Neurosci 3:46. 2009
    Vasoactive intestinal peptide (VIP) immunoreactive secretomotor neurons in the submucous plexus are involved in mediating bacterial toxin-induced hypersecretion leading to diarrhoea...
  50. ncbi The histopathology of gastrointestinal motility disorders in children
    Sonja Feichter
    Department of Pediatric Surgery, Hospital Lucerne, Lucerne, Switzerland
    Semin Pediatr Surg 18:206-11. 2009
    ..In intestinal neuronal dysplasia type B, submucous plexus development is disturbed...
  51. ncbi Nitric oxide-containing neurons in the bovine gut, with special reference to their relationship with VIP and galanin
    A Vittoria
    Department of Biological Structures, Functions and Technology, University of Naples Federico II, Italy
    Arch Histol Cytol 63:357-68. 2000
    ..NADPH-d-positive neurons were present along the myenteric plexus of the entire gut, and in the submucous plexus from the abomasum to the rectum...
  52. ncbi Stereologic description of the changing expression of constitutive nitric oxide synthase and heme oxygenase in the enteric plexuses of the pig small intestine during development
    C van Ginneken
    Laboratory of Veterinary Anatomy and Embryology, Faculty of Medical and Pharmaceutical Sciences, University of Antwerp, Slachthuislaan 68, 2060 Antwerp, Belgium
    J Comp Neurol 437:118-28. 2001
    ..It is believed that the duodenal nitrergic neurons in the inner submucous plexus could be involved in the regulation of duodenal secretion processes, whereas the region-dependent density in ..
  53. ncbi Cholinergic, nitrergic and peptidergic (Substance P- and CGRP-utilizing) innervation of the horse intestine. A histochemical and immunohistochemical study
    C Domeneghini
    Department of Veterinary Sciences and Technologies for Food Safety, Faculty of Veterinary Medicine, University of Milan, Italy
    Histol Histopathol 19:357-70. 2004
    ..CGRP immunoreactivity was detected in roundish nerve cell bodies as well as in nerve fibres of the submucous plexus, whereas SP immunoreactivity was evidenced in nerve fibres of the tunica mucosa, in nerve cell bodies and ..
  54. ncbi Distribution of nitric oxide synthase in the esophagus of the cat and monkey
    J Rodrigo
    Departamento de Neuroanatomía Comparada, Instituto Cajal, CSIC, Madrid, Spain
    J Auton Nerv Syst 70:164-79. 1998
    ..Immunoreactive nerve fibers were found pervading the myenteric plexus, submucous plexus and plexus of the muscularis mucosae, and particularly in the lower esophagus a few immunoreactive fibers ..
  55. ncbi Expression pattern of the von Hippel-Lindau protein in human tissues
    M Los
    Department of Internal Medicine, University Hospital Utrecht, The Netherlands
    Lab Invest 75:231-8. 1996
    ..nuclei, the inferior olivary nucleus of the medulla oblongata, orthosympathetic ganglia, myenteric, and submucous plexus of the colon...
  56. pmc Nitric oxide enhances inhibitory synaptic transmission and neuronal excitability in Guinea-pig submucous plexus
    Joel C Bornstein
    Department of Physiology, University of Melbourne Melbourne, Vic, Australia
    Front Neurosci 4:30. 2010
    ..Thus, NOS neurons may locally regulate several secretomotor pathways ending on common neurons...
  57. ncbi Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody
    Sebastian Hoff
    Department of Human Biology, Technische Universitat Munchen, D 85350 Freising Weihenstephan, Germany
    J Comp Neurol 509:356-71. 2008
    ..3 to 1.9 and from 5.9 to 7.0 in the human submucous plexus (SMP) and MP, respectively, whereas, in guinea pig, the glia index was 0.8-1.0 in the SMP and 1.7 in the MP...
  58. ncbi Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system
    M Schemann
    Department of Human Biology, TU Munich, Hochfeldweg 2, D 85350, Freising Weihenstephan, Germany
    Neurogastroenterol Motil 17:281-9. 2005
    ..This excitatory response occurred in 31%, 38% or 11% neurons of guinea-pig submucous plexus, human submucous plexus, or guinea-pig myenteric plexus, respectively...
  59. ncbi The development of avian enteric nervous system: distribution of artemin immunoreactivity
    Lucianna Maruccio
    Dipartimento di Strutture, Funzioni e Tecnologie Biologiche, Universita degli Studi di Napoli Federico II, Via Veterinaria 1, 80137 Naples, Italy
    Acta Histochem 110:163-71. 2008
    ..was apparent in the intestinal tract at embryonic day 7 (d7), firstly in the myenteric plexus and then in the submucous plexus. Later, artemin immunoreactive nerve fibres were also seen in the longitudinal muscle plexus, the circular ..
  60. ncbi PYY: a neuropeptide in the canine enteric nervous system
    T J McDonald
    Department of Medicine, University of Western Ontario, London, Canada
    Regul Pept 44:33-48. 1993
    ..obtained from canine intestinal and gastric myenteric plexus, and intestinal deep muscular plexus and submucous plexus, contained considerable quantities of PYY-LI which, on reverse-phase HPLC, co-eluted with a synthetic canine/..
  61. ncbi Transient expression of neuronal nitric oxide synthase by neurons of the submucous plexus of the mouse small intestine
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, 3052, Vic, Australia
    Cell Tissue Res 291:395-401. 1998
    ..of the small intestine of all mammalian species examined to date, NOS-containing neurons are sparse in the submucous plexus, and there does not appear to be an innervation of the mucosa by nerve fibres containing NOS...
  62. ncbi TrkB is necessary for the normal development of the lung
    O Garcia-Suarez
    Departamentos de Morfología y Biología Celular, Universidad de Oviedo, c Julian Claveria s n, Oviedo, Spain
    Respir Physiol Neurobiol 167:281-91. 2009
    ..neuroepithelial bodies, an important reduction in the density of nerve fibres in the bronchial smooth muscle, submucous plexus in bronchioles, and pulmonary artery walls...
  63. ncbi Postnatal and diet-dependent increases in enteric glial cells and VIP-containing neurones in preterm pigs
    E R Van Haver
    Department of Veterinary Medicine, University of Antwerp, Wilrijk, Belgium
    Neurogastroenterol Motil 20:1070-9. 2008
    ..Following TPN, VIP in the myenteric and inner submucous plexus and GFAP in the inner submucous plexus increased, while the relative volume of the total neuronal population ..
  64. ncbi [Intestinal neuronal dysplasia: association with digestive malformations]
    R Granero Cendón
    Servicio de Cirugia Pediatrica, H Infantil Universitario Virgen del Rocío, Sevilla
    Cir Pediatr 20:166-8. 2007
    ..symptoms of diarrhea or intestinal obstruction along with histopathologic diagnosis based on hyperplasia of submucous plexus with giant ganglia containing more than seven nerve cells, increased acetylcholinesterase activity in the ..
  65. ncbi L-DOPA induces concentration-dependent facilitation and inhibition of presynaptic acetylcholine release in the guinea-pig submucous plexus
    K Hirai
    Department of Autonomic Physiology, Tokyo Medical and Dental University, Japan
    Brain Res 718:105-11. 1996
    ..Neurotransmitter- or neuromodulator-like actions of L-DOPA were investigated with intracellular recordings from submucous plexus neurons of the guinea-pig caecum...
  66. ncbi Neuronal anomalies and normal muscle morphology at the hypomotile ileocecocolonic region of patients affected by idiopathic chronic constipation
    M S Faussone-Pellegrini
    Department of Human Anatomy and Histology, University of Florence, Italy
    Histol Histopathol 14:1119-34. 1999
    ..NOS-immunoreactive neurons at the myenteric plexus and significantly more NOS-immunoreactive neurons at the submucous plexus. These findings exclude a myopathy and demonstrate the existence of a neuropathy...
  67. ncbi Pronounced substance P innervation in irradiation-induced enteropathy--a study on human colon
    S Forsgren
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, S 901 87, Umea, Sweden
    Regul Pept 88:1-13. 2000
    ..The degree of SP-LI in the ganglionic cells of the submucous plexus was increased as compared to non-irradiated patients...
  68. ncbi Muscarinic excitation and inhibition of neurons in the submucous plexus of the guinea-pig caecum
    S Mihara
    Department of Physiology, Kurume University School of Medicine, Japan
    Neuroscience 31:247-57. 1989
    Intracellular recordings were made from neurons in the submucous plexus of the guinea-pig caecum...
  69. ncbi Hirschsprung's disease studied with monoclonal antineurofilament antibodies on tissue sections
    P Kluck
    Lancet 1:652-4. 1984
    ..Hirschsprung's disease showed partial staining of only some of the axon bundles in the myenteric and in the submucous plexus. In contrast, in all tissue sections from colon affected by Hirschsprung's disease there were heavily stained ..
  70. ncbi Comparison of opioid receptor distributions in the rat ileum
    A C Gray
    Department of Pharmaceutical Biology and Pharmacology, Victorian College of Pharmacy, Monash University, 381 Royal Pde, Parkville, Victoria 3052, Australia
    Life Sci 78:1610-6. 2006
    ..mu/delta co-expression was also observed in interstitial cells, which were diffusely distributed in submucous plexus preparations but generally located adjacent to myenteric plexus structures...
  71. ncbi Voltage-gated delayed rectifier K v 1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum
    Anna Costagliola
    Department of Structures, Functions and Biological Technology, University of Naples Federico II, Via F Delpino 1, 80137 Napoli, Italy
    Neurosci Lett 461:80-4. 2009
    ..EGC along interganglionic, intramuscular and vascular nerve fibres, and in S100-positive EGC of the submucous plexus. K(v)1...
  72. ncbi Calretinin and somatostatin immunoreactivities label different human submucosal neuron populations
    Andreas Kustermann
    Institute of Anatomy I, Erlangen, Germany
    Anat Rec (Hoboken) 294:858-69. 2011
    ..The functions of both populations as possible primary afferent neurons, interneurons, secretomotor neurons, or vasomotor neurons are discussed. Future morphochemical distinction of these groups may reveal different subgroups...
  73. ncbi Calretinin, β-tubulin immunohistochemistry, and submucosal nerve trunks morphology in Hirschsprung disease: possible applications in clinical practice
    Andrea Volpe
    Pediatric Surgery, Department of Women s and Children s Health, University of Padova General Pathology and Cytopathology, Section of Medical Diagnostic Sciences and Special Therapies, Department of Medicine, University of Padova, Padova, Italy
    J Pediatr Gastroenterol Nutr 57:780-7. 2013
    ....
  74. ncbi Topographic peculiarities of the submucous plexus in the human anorectum--consequences for histopathologic evaluation of rectal biopsies
    K Tafazzoli
    Department of Pediatric Surgery, University Clinic Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany
    Eur J Pediatr Surg 15:159-63. 2005
    ..morphometric analysis was carried out for each segment recording the number of ganglia and nerve cells of the submucous plexus. Neither ganglia nor nerve cells showed a uniform distribution pattern, but decreased continuously towards ..
  75. pmc Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system
    Sumei Liu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Comp Neurol 511:847-62. 2008
    ..Our results suggest important roles for TRPC channels in ENS physiology and neuronal regulation of gut function...
  76. pmc Functions and imaging of mast cell and neural axis of the gut
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 144:698-704.e4. 2013
    ..Studies of motility and functional gastrointestinal disorders would be feasible without the need for full-thickness biopsy...
  77. ncbi Submucosal plexus of dilatated gut disappears after ligation in chicken embryos: preliminary results
    H C Fiegel
    Department of Pediatric Surgery, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Eur J Pediatr Surg 16:407-10. 2006
    ..The aim of this study is to investigate the changes of the enteric nervous system (ENS) after gut ligation...
  78. ncbi Mibefradil-sensitive component involved in the plateau potential in submucosal interstitial cells of the murine proximal colon
    Aya Hotta
    Department of Regulatory Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 353:170-6. 2007
    ..0 microM. In conclusion, the initial phase of plateau potentials is partly due to the activation of T-type Ca(2+) channel in ICC(SM) from the murine proximal colon...
  79. ncbi Immunohistochemical localisation of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea pig and human enteric nervous system
    A M Harrington
    Surgical Research and Gut Motility Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville 3052, Australia
    J Chem Neuroanat 33:193-201. 2007
    ..M1r-IR present on blood vessel endothelial cells suggests that M1rs may also mediate acetylcholine's direct effect on vasoactivation...
  80. ncbi Organisation of autonomic nervous structures in the large intestine of chinchilla (Chinchilla laniger Molina)
    Elzbieta Nowak
    Department of Comparative Anatomy, Institute of Biology, Jan Kochanowski University in Kielce, Swietokrzyska 15, 25 406 Kielce, Poland
    Folia Biol (Krakow) 61:135-41. 2013
    ..The submucous plexus was distributed at several levels of mucosa and was a more dispersed structure than the myenteric plexus...
  81. ncbi Bradykinin-induced depolarisation and Ca(2+) influx through voltage-gated Ca(2+) channels in rat submucosal neurons
    Janine Avemary
    Institute for Veterinary Physiology, University of Giessen, Germany
    Eur J Pharmacol 635:87-95. 2010
    ....
  82. ncbi Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol
    Bo Yu
    School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, P R China
    Pharmazie 68:877-81. 2013
    ..These data suggested that RES is a potent deltaF508 and G551D mutant CFTR potentiator, and RES may present a novel class of therapeutic lead compounds in treating cystic fibrosis...
  83. ncbi The identification of ganglion cells in Hirschsprung disease by the immunohistochemical detection of ret oncoprotein
    Sadiqa Karim
    Department of Pathology, Baystate Medical Center Tufts University School of Medicine, Springfield, MA, USA
    Am J Clin Pathol 126:49-54. 2006
    ..GCs are identified more readily by ret immunoreactivity than by routine morphologic examination...
  84. ncbi Structure of enteric neurons
    A Brehmer
    Institute of Anatomy 1, University of Erlangen Nuremberg, Germany
    Adv Anat Embryol Cell Biol 186:1-91. 2006
    ..Future investigations of morpho-chemical characteristics of human enteric neurons including also other cytoskeletal markers will provide a broader basis for neurohistopathological diagnostics of gut diseases...
  85. ncbi Relaxin exerts two opposite effects on mechanical activity and nitric oxide synthase expression in the mouse colon
    M C Baccari
    Department of Physiological Sciences, University of Florence, Florence, Italy
    Am J Physiol Endocrinol Metab 303:E1142-50. 2012
    ..These findings may help to better understand the physiology of NO in the gastrointestinal tract and the role that the "relaxin-NO" system plays in motor disorders such as functional bowel disease...
  86. pmc Chemical coding of zinc-enriched neurons in the intramural ganglia of the porcine jejunum
    Joanna Wojtkiewicz
    Faculty Medical Sciences, Department of Neurology and Neurosurgery, Stem Cell Research Laboratory, University of Warmia and Mazury, ul Warszawska 30, 10 082, Olsztyn, Poland
    Cell Tissue Res 350:215-23. 2012
    ....
  87. ncbi Substance P as a neuronal factor in the enteric nervous system of the porcine descending colon in physiological conditions and during selected pathogenic processes
    Slawomir Gonkowski
    Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Biofactors 39:542-51. 2013
    ..The obtained results suggest that SP-LI nerve structures of the ENS may participate in various pathological processes in the porcine descending colon and exact functions of SP probably depend on the type of the pathological factor...
  88. ncbi Rectal inflammatory fibroid polyp resected with endoscopic submucosal dissection
    Takaya Shimura
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya
    Intern Med 47:2029-31. 2008
    ..The lesion was completely resected by endoscopic submucosal dissection (ESD) and was histopathologically diagnosed as IFP. We report herein a very rare rectal IFP that could be treated and diagnosed with ESD...
  89. ncbi The mechanism of intestinal motility in homozygous mutant Ncx/Hox11L.1-deficient mice--a model for intestinal neuronal dysplasia
    Hiroyuki Kobayashi
    Department of General Medicine and Hospital Administration, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Pediatr Surg 42:2062-6. 2007
    ..Homozygous mutant Ncx/Hox11L.1-deficient (Ncx-/-) mice develop mega-ileo-ceco-colon with a caliber change in the proximal colon. This study investigated the mechanism of intestinal motility in these mice...
  90. ncbi Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion
    Dervla O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland Department of Physiology, University College Cork, Cork, Ireland
    Brain Behav Immun 30:115-24. 2013
    ..These studies aim to explore the relationship between IL-6 and the stress peptide, corticotropin-releasing factor (CRF) in colonic submucosal neurons...
  91. ncbi Intestinal neuronal dysplasia type B: one giant ganglion is not good enough
    William A Meier-Ruge
    Institute of Pathology, University Medical School Basel, Basel, Switzerland
    Pediatr Dev Pathol 9:444-52. 2006
    ..Rigorous application of these criteria, under standardized laboratory conditions, is crucial for accurate diagnosis and future advances in this field...
  92. ncbi Spatiotemporal expression pattern of DsRedT3/CCK gene construct during postnatal development of myenteric plexus in transgenic mice
    Zoltan Mate
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Cell Tissue Res 352:199-206. 2013
    ..The coexistence of CCK and 5-HT in the majority of these neurones suggests their possible regulatory role in feeding at the suckling to weaning transition...
  93. pmc The spatial arrangement of the human large intestinal wall blood circulation
    David Kachlik
    Third Faculty of Medicine, Charles University in Prague, Ruská, Praha, Czech Republic
    J Anat 216:335-43. 2010
    ..of both short and long vasa recta merged in the colon wall, pierced the muscular layer and spread out as the submucous plexus, which extended throughout the whole intestine without any interruption...
  94. ncbi Lymphoid follicles of the ileal Peyer's patch of lambs express low levels of PrP, as demonstrated by quantitative real-time RT-PCR on microdissected tissue compartments, in situ hybridization and immunohistochemistry
    Lars Austbø
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    J Gen Virol 87:3463-71. 2006
    ....
  95. ncbi Substance P (NK1) receptor in relation to substance P innervation in rat duodenum after irradiation
    U Höckerfelt
    Department of Integrative Medical Biology, Anatomy, Umea University, SE 901 87, Umea, Sweden
    Regul Pept 98:115-26. 2001
    ..These findings support a suggestion that an increased level of SP after irradiation may contribute to the dose-dependent gastrointestinal adverse effects that occur after radiotherapy...
  96. ncbi Action of bradykinin in the submucosal plexus of guinea pig small intestine
    Hong Zhen Hu
    Department of Physiology and Cell Biology, College of Medicine and Public Health, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    J Pharmacol Exp Ther 309:320-7. 2004
    ..Pathophysiological significance of the excitatory actions on secretomotor neurons might be stimulated mucosal secretion and the secretory diarrhea associated with intestinal inflammatory states...
  97. ncbi Chemical coding of neurons expressing delta- and kappa-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileum
    Sutthasinee Poonyachoti
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108 6010, USA
    Cell Tissue Res 307:23-33. 2002
    ....
  98. ncbi Increased acid-sensing ion channel ASIC-3 in inflamed human intestine
    Y Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Eur J Gastroenterol Hepatol 13:891-6. 2001
    ..CONCLUSIONS: Increased ASIC-3 in inflamed intestine suggests a role in pain or dysmotility, for which ASICs represent new therapeutic targets...
  99. ncbi Localization and characterization of neuropeptide receptors in human colon
    M Rettenbacher
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Switzerland
    Naunyn Schmiedebergs Arch Pharmacol 364:291-304. 2001
    ....
  100. ncbi Hirschsprung lost his nerve
    Christopher R Erwin
    Gastroenterology 125:1900-2. 2003
  101. pmc Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig
    Alan E Lomax
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada
    J Physiol 564:863-75. 2005
    ..This is the first demonstration of alterations in synaptic pharmacology in the enteric nervous system during inflammation...

Research Grants5

  1. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  2. OPIATE ACTIONS AND DEPENDENCE--SINGLE NEURON STUDIES
    R North; Fiscal Year: 1993
    ..The cells are chosen for study (guinea-pig myenteric and submucous plexus neurons) because earlier work has shown them to express mu, delta, and kappa receptors...
  3. Enteric Nervous System 2003
    Keith Sharkey; Fiscal Year: 2003
    ..From this picture there will be gaps - these are the challenges for the future. ..
  4. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..