submucous plexus

Summary

Summary: One of two ganglionated neural networks which together form the enteric nervous system. The submucous (Meissner's) plexus is in the connective tissue of the submucosa. Its neurons innervate the epithelium, blood vessels, endocrine cells, other submucosal ganglia, and myenteric ganglia, and play an important role in regulating ion and water transport. (From FASEB J 1989;3:127-38)

Top Publications

  1. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
  2. doi Two submucosal nerve plexus in human intestines
    Axel Brehmer
    Institute of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Histochem Cell Biol 133:149-61. 2010
  3. ncbi Classes of enteric nerve cells in the guinea-pig small intestine
    S J Brookes
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia 5001
    Anat Rec 262:58-70. 2001
  4. ncbi Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans
    J P Timmermans
    Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium
    Anat Rec 262:71-8. 2001
  5. doi Activity of protease-activated receptors in the human submucous plexus
    Kerstin Mueller
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 141:2088-2097.e1. 2011
  6. ncbi Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
  7. pmc ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    R L Monro
    Department of Physiology, University of Melbourne, Parkville 3010, Victoria, Australia
    J Physiol 556:571-84. 2004
  8. ncbi Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid
    Jacqueline Nelisis Zanoni
    Department of Morphophysiological Sciences, Universidade Estadual de Maringa, Brasil
    Arq Neuropsiquiatr 60:32-37. 2002
  9. pmc A non-adrenergic, non-cholinergic slow inhibitory post-synaptic potential in neurones of the guinea-pig submucous plexus
    S Mihara
    Neuropharmacology Laboratory, Massachusetts Institute of Technology, Cambridge 02139
    J Physiol 390:357-65. 1987
  10. pmc 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    Jaime Pei Pei Foong
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 298:G384-94. 2010

Research Grants

  1. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
  2. NEURAL CONTROL OF LARGE INTESTINAL MUCOSA
    Helen Cooke; Fiscal Year: 1993
  3. MULTIPLE SITE OPTICAL RECORDING OF MEMBRANE POTENTIAL
    BRIAN SALZBERG; Fiscal Year: 2003
  4. ADENOSINE DERIVATIVES AND TRANSMITTER RELEASE
    EUGENE SILINSKY; Fiscal Year: 1993
  5. MULTIPLE SITE OPTICAL RECORDING OF MEMBRANE POTENTIAL
    BRIAN SALZBERG; Fiscal Year: 2000
  6. Enteric Nervous System 2003
    Keith Sharkey; Fiscal Year: 2003
  7. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS CHRISTOFI; Fiscal Year: 2005
  8. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS CHRISTOFI; Fiscal Year: 2007
  9. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2007
  10. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010

Detail Information

Publications161 found, 100 shown here

  1. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
    ..dye di-8-ANEPPS to monitor directly membrane potential changes and thereby neuronal excitability in the human submucous plexus from surgical specimens of 110 patients (2137 neurones, 273 ganglia)...
  2. doi Two submucosal nerve plexus in human intestines
    Axel Brehmer
    Institute of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
    Histochem Cell Biol 133:149-61. 2010
    ..For use of eponyms for two different submucosal plexus, the names of Meissner (inner) and Schabadasch (outer) are historically justified...
  3. ncbi Classes of enteric nerve cells in the guinea-pig small intestine
    S J Brookes
    Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia 5001
    Anat Rec 262:58-70. 2001
    ..This provides a firm anatomical foundation for the systematic analysis of how the enteric nervous system normally functions and how it goes wrong in various clinically important disorders...
  4. ncbi Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans
    J P Timmermans
    Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium
    Anat Rec 262:71-8. 2001
    ..that the close and exclusive association, which has been assumed so far between the efferent pathways of the submucous plexus and regulation of intestinal secretion/absorption on the one hand and between the myenteric plexus and ..
  5. doi Activity of protease-activated receptors in the human submucous plexus
    Kerstin Mueller
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 141:2088-2097.e1. 2011
    ..Studies in several animal models indicate the involvement of neural PARs. We studied the actions of different PAR-activating peptides (AP) in the human submucous plexus and performed comparative studies in guinea pig submucous neurons.
  6. ncbi Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
    ..Recently, the neural 5-HT3 receptor received a lot of attention as a possible target in functional bowel diseases. Yet, the 5-HT3 receptor-mediated changes in properties of human enteric neurons is unknown...
  7. pmc ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    R L Monro
    Department of Physiology, University of Melbourne, Parkville 3010, Victoria, Australia
    J Physiol 556:571-84. 2004
    ..aimed to identify neurotransmitters responsible for non-cholinergic excitatory synaptic transmission in the submucous plexus of the guinea pig ileum. Intracellular recordings were made from secretomotor and vasodilator neurones...
  8. ncbi Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid
    Jacqueline Nelisis Zanoni
    Department of Morphophysiological Sciences, Universidade Estadual de Maringa, Brasil
    Arq Neuropsiquiatr 60:32-37. 2002
    ..ascorbic acid (AA) supplementation on the neurons that produce the vasoactive intestinal peptide (VIP) in the submucous plexus of the ileum of rat, four months after the induction of experimental diabetes mellitus with streptozotocin...
  9. pmc A non-adrenergic, non-cholinergic slow inhibitory post-synaptic potential in neurones of the guinea-pig submucous plexus
    S Mihara
    Neuropharmacology Laboratory, Massachusetts Institute of Technology, Cambridge 02139
    J Physiol 390:357-65. 1987
    1. Intracellular recordings were made from neurones in the submucous plexus of guinea-pig ileum and caecum. The responses to electrical stimulation of fibre strands entering the nodes of the plexus were studied. 2...
  10. pmc 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    Jaime Pei Pei Foong
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 298:G384-94. 2010
    Vasoactive intestinal peptide (VIP) immunoreactive neurons are important secretomotor neurons in the submucous plexus. They are the only submucosal neurons to receive inhibitory inputs and exhibit both noradrenergic and nonadrenergic ..
  11. ncbi Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum
    David E Reed
    Gastrointestinal Diseases Research Unit, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G608-14. 2007
    ..This pathway projects in parallel with motor and vasodilator reflexes, and this common pathway may enable coordination of intestinal secretion, blood flow, and motility...
  12. ncbi Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease
    J Schneider
    Department of General Surgery, Eberhard-Karls University, Tuebingen, Germany
    Neurogastroenterol Motil 13:255-64. 2001
    ..Thickened CGRP-fibres occurred in CD. We identified neurochemically distinct populations in the human submucous plexus. The increase in the VIP/- population, extensive colocalization of ChAT and NOS and hypertrophied CGRP fibres ..
  13. doi Neuromuscular changes in a rat model of colitis
    Mariona Aulí
    Department of Cell Biology, Physiology and Immunology, Veterinary Faculty, Universitat Autonoma de Barcelona, Spain
    Auton Neurosci 141:10-21. 2008
    ..T. spiralis-induced colitis causes profound neuromuscular adaptations. The reduction in NOS neurons appears to underlie changes in motility...
  14. ncbi Hirschsprung lost his nerve
    Christopher R Erwin
    Gastroenterology 125:1900-2. 2003
  15. ncbi The influence of experimental Bacteroides fragilis infection on substance P and somatostatin-immunoreactive neural elements in the porcine ascending colon - a preliminary report
    Sławomir Gonkowski
    Department of Clinical Physiology, University of Warmia and Mazury, Olsztyn, Poland
    Folia Morphol (Warsz) 62:455-7. 2003
    ..Thus, the present results suggest that SP- and SOM-immunoreactive (SOM-IR) elements of the enteric nervous system play a part in the control of colonic activity during BFIC...
  16. ncbi Expression of Tie-2 in human peripheral and autonomic nervous system
    S Poncet
    University of Lausanne, Institute of Pathology, CHUV, Lausanne, Switzerland
    Neuropathol Appl Neurobiol 29:361-9. 2003
    ..Thus, attempts to disrupt the tumour vessels by manipulation of the Tie-2 system in tumours may result in side-effects in peripheral nerves...
  17. ncbi Expression of Notch1 and Jagged2 in the enteric nervous system
    Guy R Sander
    Child Health Research Institute, Womens and Childrens Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Histochem Cytochem 51:969-72. 2003
    ..We propose that Notch1 and Jagged2 have a continuing role in the maintenance and function of neuronal cells in the adult enteric nervous system...
  18. doi Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development
    A B M da Silveira
    Research Center Rene Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    Parasitology 135:1337-42. 2008
    ..We believe that this increased regeneration can be interpreted as an accentuated neuronal plasticity that may be a response of the ENS to avoid megacolon propagation to the entire organ and maintain the colon functional innervation...
  19. pmc Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons
    David E Reed
    Gastrointestinal Diseases Research Unit, Queen s University, Kingston, Ontario, Canada
    J Physiol 547:531-42. 2003
    ..This signalling pathway between immune cells and neurons is a previously unrecognized mechanism that could contribute to chronic alterations in visceral function...
  20. ncbi Morphology and distribution of nitric oxide synthase-, neurokinin-1 receptor-, calretinin-, calbindin-, and neurofilament-M-immunoreactive neurons in the myenteric and submucosal plexuses of the rat small intestine
    Ayman I Sayegh
    Gastroenterology and Imaging Laboratories, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:209-16. 2003
    ..The distribution of these phenotypic markers may assist future work that elucidates the functional activities of these enteric neurons such as control of intestinal motility and adaptation to the entry of gastric contents...
  21. ncbi An immunohistochemical study of the organization of ganglia and nerve fibres in the mucosa of the porcine intestine
    O B Balemba
    Department of Veterinary Anatomy, Sokoine University of Agriculture, Morogoro, Tanzania, Denmark
    Anat Histol Embryol 31:237-46. 2002
    ....
  22. ncbi Neuronal nitric oxide synthase activity is increased during granulomatous inflammation in the colon and caecum of pigs infected with Schistosoma japonicum
    O B Balemba
    Department of Veterinary Anatomy, Sokoine University of Agriculture, Morogoro, Tanzania
    Auton Neurosci 99:1-12. 2002
    ..a significant increase in the nerve cell body density of nNOS immunoreactive nerve cell bodies in the inner submucous plexus, outer submucous plexus and in the myenteric plexus...
  23. ncbi Structure of enteric neurons
    A Brehmer
    Institute of Anatomy 1, University of Erlangen Nuremberg, Germany
    Adv Anat Embryol Cell Biol 186:1-91. 2006
    ..Future investigations of morpho-chemical characteristics of human enteric neurons including also other cytoskeletal markers will provide a broader basis for neurohistopathological diagnostics of gut diseases...
  24. ncbi Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis
    Alan E Lomax
    Gastrointestinal Diseases Research Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G482-91. 2007
    ..In conclusion, sustained alterations in enteric neural signaling occur following the resolution of colitis, which are accompanied by functional changes in the absence of active inflammation...
  25. ncbi Mesenteric transection decreases expression of interstitial cells of Cajal in an experimental model
    M Nishimura
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Surg 94:483-90. 2007
    ..The aim of this study was to examine the number of interstitial cells of Cajal (ICCs) and ganglion cells in the distal colon partially denervated by mesenteric transection in a rat model...
  26. ncbi Rectal biopsy in the diagnosis of neuronal intranuclear hyaline inclusion disease
    Romana Kulikova-Schupak
    Division of Pediatric Neurology, Columbia University, New York, New York, USA
    J Child Neurol 19:59-62. 2004
    ..Rectal biopsies should be considered in children presenting with otherwise unexplained multisystem degeneration, particularly in the presence of both upper and lower motoneuron signs accompanied by behavioral problems...
  27. ncbi Identification and localization of estrogen receptor alpha- and beta-positive cells in adult male and female mouse intestine at various estrogen levels
    Naoko Kawano
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Histochem Cell Biol 121:399-405. 2004
    ..Our results indicate that estrogen and estrogenic compounds may exert their actions on the intestine in two ways; one is through interstitial macrophages and the other is through intestinal neurons...
  28. ncbi Expression and distribution of TTX-sensitive sodium channel alpha subunits in the enteric nervous system
    Aaron C Bartoo
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Program in Neuroscience, Washington State University, Pullman, Washington 99164 6520, USA
    J Comp Neurol 486:117-31. 2005
    ..These data suggest that Na(v)1.1 may not be highly expressed in the ENS, but that Na(v)1.2, Na(v)1.3, and Na(v)1.6, and possibly Na(v)1.7, have broadly important and distinct functions in the ENS...
  29. pmc Aquaporin-4 water channels in enteric neurons
    Mia M Thi
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    J Neurosci Res 86:448-56. 2008
    ..It is known that submucosal neurons control transport processes in the intestinal mucosa, and the high percentage of aquaporin-4-positive submucosal neurons suggests that aquaporin-4 contributes to this function...
  30. ncbi The tight junction component protein, claudin-4, is expressed by enteric neurons in the rat distal colon
    Shin Ichiro Karaki
    Laboratory of Physiology, Institute for Environmental Sciences, and Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurosci Lett 428:88-92. 2007
    ..In conclusion, the present study clearly shows that claudin-4 is expressed by enteric neurons. This is the first evidence that the neuron itself expresses the TJ component protein, claudin-4, in the nervous system...
  31. ncbi Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system
    Sumei Liu
    Department of Physiology and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210 1218, USA
    J Comp Neurol 481:284-98. 2005
    ..Actions on enteric neurons might underlie the neural mechanisms by which stress-related release of CRF in the periphery alters intestinal propulsive motor function, mucosal secretion, and barrier functions...
  32. ncbi L-aspartate-immunoreactive neurons in the rat enteric nervous system
    Masato Nagahama
    Department of Anatomy II, Mie University School of Medicine, 2 174 Edobashi, 514 0001, Tsu, Mie, Japan
    Cell Tissue Res 318:483-92. 2004
    ..The presence of enteric L-Asp-immunoreactive neurons provides strong support for the proposal that L-Asp is a neuromodulator in the rat ENS...
  33. ncbi The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis
    V Remorgida
    Department of Obstetrics and Gynaecology, Department of General Surgery and Transplant, San Martino Hospital, University of Genoa, Largo R Benzi 1, 16132 Genoa, Italy
    Hum Reprod 20:264-71. 2005
    ..Our aim was to investigate the relationships between gastrointestinal symptoms and histological findings in women with bowel endometriosis...
  34. ncbi Immunohistochemical localisation of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea pig and human enteric nervous system
    A M Harrington
    Surgical Research and Gut Motility Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville 3052, Australia
    J Chem Neuroanat 33:193-201. 2007
    ..M1r-IR present on blood vessel endothelial cells suggests that M1rs may also mediate acetylcholine's direct effect on vasoactivation...
  35. ncbi Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal
    Yutaka Okishio
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    J Smooth Muscle Res 41:163-74. 2005
    ..It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum...
  36. ncbi Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin
    Zhenghua Xiang
    Department of Biochemistry and Molecular Biology, Second Military Medical University, 200433, Shanghai, People s Republic of China
    Histochem Cell Biol 124:379-90. 2005
    ....
  37. ncbi The identification of ganglion cells in Hirschsprung disease by the immunohistochemical detection of ret oncoprotein
    Sadiqa Karim
    Department of Pathology, Baystate Medical Center Tufts University School of Medicine, Springfield, MA, USA
    Am J Clin Pathol 126:49-54. 2006
    ..GCs are identified more readily by ret immunoreactivity than by routine morphologic examination...
  38. ncbi Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep
    Roberto Chiocchetti
    Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy
    Cell Tissue Res 318:289-303. 2004
    ..Thus, CALB is a marker of most Dogiel type II neurons in the sheep but is not confined to Dogiel II neurons. CGRP is a more selective marker of Dogiel type II neurons, being only found in this neuron type...
  39. ncbi Histological studies on Hirschsprung's disease and its allied disorders in childhood
    Ryouichi Tomita
    First Department of Surgery, Nihon University School of Medicine, Japan
    Hepatogastroenterology 51:1042-4. 2004
    ....
  40. ncbi Primary afferent neurons intrinsic to the guinea-pig intestine, like primary afferent neurons of spinal and cranial sensory ganglia, bind the lectin, IB4
    Anderson Hind
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Cell Tissue Res 321:151-7. 2005
    ..Strongly reactive neurons are absent from the gastric corpus. Thus, IB4 binding reveals primary afferent neurons with similar morphologies, patterns of binding and physiological roles in enteric, dorsal root and trigeminal ganglia...
  41. ncbi Chemical coding and electrophysiology of enteric neurons expressing neurofilament 145 in guinea pig gastrointestinal tract
    Hong Zhen Hu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    J Comp Neurol 442:189-203. 2002
    ..Absence of NF145 from ganglion cells in the submucosal plexus is an example of differences between myenteric and submucosal components of the enteric nervous system...
  42. ncbi Evidence supporting presence of two pacemakers in rat colon
    L Plujà
    Department of Cell Biology, Physiology, and Immunology, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Catalunya, Spain
    Am J Physiol Gastrointest Liver Physiol 281:G255-66. 2001
    ..This is the first report showing consistent slow wave activity in the rodent colon...
  43. ncbi Increased acid-sensing ion channel ASIC-3 in inflamed human intestine
    Y Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Eur J Gastroenterol Hepatol 13:891-6. 2001
    ..CONCLUSIONS: Increased ASIC-3 in inflamed intestine suggests a role in pain or dysmotility, for which ASICs represent new therapeutic targets...
  44. ncbi Localisation and neural control of the release of calcitonin gene-related peptide (CGRP) from the isolated perfused porcine ileum
    T N Rasmussen
    Department of Surgical Gastroenterology C, Rigshospitalet and Departments of Medical Physiology and Anatomy B, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Regul Pept 98:137-43. 2001
    ..The stimulatory effect of capsaicin suggests that CGRP is also released from extrinsic sensory neurons...
  45. ncbi Localization and characterization of neuropeptide receptors in human colon
    M Rettenbacher
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Switzerland
    Naunyn Schmiedebergs Arch Pharmacol 364:291-304. 2001
    ....
  46. ncbi P2X(7) receptors in the enteric nervous system of guinea-pig small intestine
    H Z Hu
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio 43210-1218, USA
    J Comp Neurol 440:299-310. 2001
    ..The mucosa, submucosal blood vessels, and the circular muscle coat also showed P2X(7) receptor immunoreactivity...
  47. ncbi Neuronal distribution and subcellular localization of HCNP-like immunoreactivity in rat small intestine
    E Katada
    Second Department of Internal Medicine, Nagoya City University School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Neurocytol 29:199-207. 2000
    ....
  48. ncbi Expression of 5-HT3 receptors in the rat gastrointestinal tract
    Jorg Glatzle
    Department of Anatomy, Physiology, and Cell Biology, University of California Davis School of Veterinary Medicine, Davis, California 95616, USA
    Gastroenterology 123:217-26. 2002
    ..The aim of the present study was to elucidate the cellular sites of 5-HT3R expression in the rat GI tract using immunohistochemistry...
  49. ncbi Chemical coding of neurons expressing delta- and kappa-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileum
    Sutthasinee Poonyachoti
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108 6010, USA
    Cell Tissue Res 307:23-33. 2002
    ....
  50. ncbi The development of colon innervation in trisomy 16 mice and Hirschsprung's disease
    J C Li
    Department of Lymphology, Zhejiang University Medical School, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 7:16-21. 2001
    ..To study the colon innervation of trisomy 16 mouse, an animal model for Down's syndrome, and the expression of protein gene product 9.5 (PGP 9.5) in the stenosed segment of colon in Hirschsprung's disease (HD)...
  51. ncbi Distribution of enkephalin-like immunoreactivity in the cat digestive tract
    D Bagnol
    Université d Aix Marseille III, Faculte des Sciences et Techniques de Saint Jerome, France
    J Auton Nerv Syst 64:1-11. 1997
    ..immunoreactivity was detected in the cell bodies of numerous myenteric plexus neurons but those of only a few submucous plexus neurons...
  52. pmc Purinergic receptors and gastrointestinal secretomotor function
    Fievos Leontiou Christofi
    Department of Anesthesiology, The Ohio State University, Columbus, OH, 43210, USA
    Purinergic Signal 4:213-36. 2008
    ..among other mediators) and initiates local reflexes by activating intrinsic primary afferent neurons of the submucous plexus. Signals are conveyed to interneurons or secretomotor neurons to stimulate chloride and fluid secretion...
  53. ncbi Control systems of gastrointestinal motility are immature at birth in dogs
    E E Daniel
    Department of Biomedical Sciences, Health Sciences, McMaster University, 1200 Main St W, Hamilton L8N 3Z5, ON, Canada
    Neurogastroenterol Motil 11:375-92. 1999
    ..Ganglia were present where expected in the Myp and submucous plexus (SMP)...
  54. pmc The spatial arrangement of the human large intestinal wall blood circulation
    David Kachlik
    Third Faculty of Medicine, Charles University in Prague, Ruská, Praha, Czech Republic
    J Anat 216:335-43. 2010
    ..of both short and long vasa recta merged in the colon wall, pierced the muscular layer and spread out as the submucous plexus, which extended throughout the whole intestine without any interruption...
  55. doi Distribution of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) nerve structures in the porcine large intestine
    Slawomir Gonkowski
    Division of Clinical Physiology, Department of Functional Morphology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10 957 Olsztyn Kortowo, Poland
    Acta Vet Hung 57:509-20. 2009
    ..studied by immunohistochemistry in the circular muscle layer, myenteric (MP), outer submucous (OSP) and inner submucous plexus (ISP) as well as in the mucosal layer of six regions of the large bowel: caecum, centripetal and centrifugal ..
  56. ncbi [Enzyme histochemical diagnosis of gastrointestinal motility disorders. A laboratory guide]
    E Bruder
    Institut fur Pathologie, Universitatsspital Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
    Pathologe 28:93-100. 2007
    ..succinic dehydrogenase and nitroxide synthase selectively demonstrate the nerve cells of the myenteric and submucous plexus. These enzyme histochemical techniques require fresh, native tissue...
  57. ncbi Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system
    Norbert Braun
    Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Strasse 9, D 60439 Frankfurt am Main, Germany
    Glia 45:124-32. 2004
    ..ganglia, and with the enteric glia surrounding the cell bodies of ganglionic neurons of the myenteric and the submucous plexus. In contrast to NTPDase1, NTPDase2 preferentially hydrolyzes nucleoside triphosphates over nucleoside ..
  58. pmc mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum
    Jaime Pei Pei Foong
    Department of Physiology, University of Melbourne Parkville, Australia
    Front Neurosci 3:46. 2009
    Vasoactive intestinal peptide (VIP) immunoreactive secretomotor neurons in the submucous plexus are involved in mediating bacterial toxin-induced hypersecretion leading to diarrhoea...
  59. doi The histopathology of gastrointestinal motility disorders in children
    Sonja Feichter
    Department of Pediatric Surgery, Hospital Lucerne, Lucerne, Switzerland
    Semin Pediatr Surg 18:206-11. 2009
    ..In intestinal neuronal dysplasia type B, submucous plexus development is disturbed...
  60. ncbi Nitric oxide-containing neurons in the bovine gut, with special reference to their relationship with VIP and galanin
    A Vittoria
    Department of Biological Structures, Functions and Technology, University of Naples Federico II, Italy
    Arch Histol Cytol 63:357-68. 2000
    ..NADPH-d-positive neurons were present along the myenteric plexus of the entire gut, and in the submucous plexus from the abomasum to the rectum...
  61. ncbi Stereologic description of the changing expression of constitutive nitric oxide synthase and heme oxygenase in the enteric plexuses of the pig small intestine during development
    C van Ginneken
    Laboratory of Veterinary Anatomy and Embryology, Faculty of Medical and Pharmaceutical Sciences, University of Antwerp, Slachthuislaan 68, 2060 Antwerp, Belgium
    J Comp Neurol 437:118-28. 2001
    ..It is believed that the duodenal nitrergic neurons in the inner submucous plexus could be involved in the regulation of duodenal secretion processes, whereas the region-dependent density in ..
  62. ncbi Cholinergic, nitrergic and peptidergic (Substance P- and CGRP-utilizing) innervation of the horse intestine. A histochemical and immunohistochemical study
    C Domeneghini
    Department of Veterinary Sciences and Technologies for Food Safety, Faculty of Veterinary Medicine, University of Milan, Italy
    Histol Histopathol 19:357-70. 2004
    ..CGRP immunoreactivity was detected in roundish nerve cell bodies as well as in nerve fibres of the submucous plexus, whereas SP immunoreactivity was evidenced in nerve fibres of the tunica mucosa, in nerve cell bodies and ..
  63. ncbi Expression pattern of the von Hippel-Lindau protein in human tissues
    M Los
    Department of Internal Medicine, University Hospital Utrecht, The Netherlands
    Lab Invest 75:231-8. 1996
    ..nuclei, the inferior olivary nucleus of the medulla oblongata, orthosympathetic ganglia, myenteric, and submucous plexus of the colon...
  64. pmc Nitric oxide enhances inhibitory synaptic transmission and neuronal excitability in Guinea-pig submucous plexus
    Joel C Bornstein
    Department of Physiology, University of Melbourne Melbourne, Vic, Australia
    Front Neurosci 4:30. 2010
    ..Thus, NOS neurons may locally regulate several secretomotor pathways ending on common neurons...
  65. ncbi Distribution of nitric oxide synthase in the esophagus of the cat and monkey
    J Rodrigo
    Departamento de Neuroanatomía Comparada, Instituto Cajal, CSIC, Madrid, Spain
    J Auton Nerv Syst 70:164-79. 1998
    ..Immunoreactive nerve fibers were found pervading the myenteric plexus, submucous plexus and plexus of the muscularis mucosae, and particularly in the lower esophagus a few immunoreactive fibers ..
  66. doi Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody
    Sebastian Hoff
    Department of Human Biology, Technische Universitat Munchen, D 85350 Freising Weihenstephan, Germany
    J Comp Neurol 509:356-71. 2008
    ..3 to 1.9 and from 5.9 to 7.0 in the human submucous plexus (SMP) and MP, respectively, whereas, in guinea pig, the glia index was 0.8-1.0 in the SMP and 1.7 in the MP...
  67. ncbi Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system
    M Schemann
    Department of Human Biology, TU Munich, Hochfeldweg 2, D 85350, Freising Weihenstephan, Germany
    Neurogastroenterol Motil 17:281-9. 2005
    ..This excitatory response occurred in 31%, 38% or 11% neurons of guinea-pig submucous plexus, human submucous plexus, or guinea-pig myenteric plexus, respectively...
  68. ncbi The development of avian enteric nervous system: distribution of artemin immunoreactivity
    Lucianna Maruccio
    Dipartimento di Strutture, Funzioni e Tecnologie Biologiche, Universita degli Studi di Napoli Federico II, Via Veterinaria 1, 80137 Naples, Italy
    Acta Histochem 110:163-71. 2008
    ..was apparent in the intestinal tract at embryonic day 7 (d7), firstly in the myenteric plexus and then in the submucous plexus. Later, artemin immunoreactive nerve fibres were also seen in the longitudinal muscle plexus, the circular ..
  69. ncbi PYY: a neuropeptide in the canine enteric nervous system
    T J McDonald
    Department of Medicine, University of Western Ontario, London, Canada
    Regul Pept 44:33-48. 1993
    ..obtained from canine intestinal and gastric myenteric plexus, and intestinal deep muscular plexus and submucous plexus, contained considerable quantities of PYY-LI which, on reverse-phase HPLC, co-eluted with a synthetic canine/..
  70. doi TrkB is necessary for the normal development of the lung
    O Garcia-Suarez
    Departamentos de Morfología y Biología Celular, Universidad de Oviedo, c Julian Claveria s n, Oviedo, Spain
    Respir Physiol Neurobiol 167:281-91. 2009
    ..neuroepithelial bodies, an important reduction in the density of nerve fibres in the bronchial smooth muscle, submucous plexus in bronchioles, and pulmonary artery walls...
  71. ncbi Transient expression of neuronal nitric oxide synthase by neurons of the submucous plexus of the mouse small intestine
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, 3052, Vic, Australia
    Cell Tissue Res 291:395-401. 1998
    ..of the small intestine of all mammalian species examined to date, NOS-containing neurons are sparse in the submucous plexus, and there does not appear to be an innervation of the mucosa by nerve fibres containing NOS...
  72. ncbi L-DOPA induces concentration-dependent facilitation and inhibition of presynaptic acetylcholine release in the guinea-pig submucous plexus
    K Hirai
    Department of Autonomic Physiology, Tokyo Medical and Dental University, Japan
    Brain Res 718:105-11. 1996
    ..Neurotransmitter- or neuromodulator-like actions of L-DOPA were investigated with intracellular recordings from submucous plexus neurons of the guinea-pig caecum...
  73. ncbi [Intestinal neuronal dysplasia: association with digestive malformations]
    R Granero Cendón
    Servicio de Cirugia Pediatrica, H Infantil Universitario Virgen del Rocío, Sevilla
    Cir Pediatr 20:166-8. 2007
    ..symptoms of diarrhea or intestinal obstruction along with histopathologic diagnosis based on hyperplasia of submucous plexus with giant ganglia containing more than seven nerve cells, increased acetylcholinesterase activity in the ..
  74. doi Postnatal and diet-dependent increases in enteric glial cells and VIP-containing neurones in preterm pigs
    E R Van Haver
    Department of Veterinary Medicine, University of Antwerp, Wilrijk, Belgium
    Neurogastroenterol Motil 20:1070-9. 2008
    ..Following TPN, VIP in the myenteric and inner submucous plexus and GFAP in the inner submucous plexus increased, while the relative volume of the total neuronal population ..
  75. ncbi Neuronal anomalies and normal muscle morphology at the hypomotile ileocecocolonic region of patients affected by idiopathic chronic constipation
    M S Faussone-Pellegrini
    Department of Human Anatomy and Histology, University of Florence, Italy
    Histol Histopathol 14:1119-34. 1999
    ..NOS-immunoreactive neurons at the myenteric plexus and significantly more NOS-immunoreactive neurons at the submucous plexus. These findings exclude a myopathy and demonstrate the existence of a neuropathy...
  76. ncbi Pronounced substance P innervation in irradiation-induced enteropathy--a study on human colon
    S Forsgren
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, S 901 87, Umea, Sweden
    Regul Pept 88:1-13. 2000
    ..The degree of SP-LI in the ganglionic cells of the submucous plexus was increased as compared to non-irradiated patients...
  77. doi Electrophysiological and morphological properties of submucosal neurons in the mouse distal colon
    V Wong
    Gastrointestinal Diseases Research Unit, Queen s University, Kingston, ON, Canada
    Neurogastroenterol Motil 20:725-34. 2008
    ..This study has shown that mouse distal colon submucosal ganglia are relatively small and, based on combined morphological and electrophysiological features, most neurons exhibit S-type characteristics...
  78. ncbi Neuroimmune interactions in guinea pig stomach and small intestine
    Sumei Liu
    Department of Physiology and Cell Biology, Ohio State University, College of Medicine and Public Health, Columbus 43210, USA
    Am J Physiol Gastrointest Liver Physiol 284:G154-64. 2003
    ..Histamine, prostaglandins, and leukotrienes are paracrine signals in the communication pathway from mast cells to the small intestinal ENS...
  79. ncbi Neurochemical coding of the enteric nervous system in chagasic patients with megacolon
    A B M da Silveira
    Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antônio Carlos 627, Pampulha, Belo Horizonte, Minas Gerais, CEP, 31270 901, Brazil
    Dig Dis Sci 52:2877-83. 2007
    ..These results suggest a selective destruction of enteric neurons in the colon of chagasic patients with megacolon, pointing to an important discovery in the mechanism of pathogenesis of Chagas' disease...
  80. ncbi Quantitative morphometric analysis of the submucous plexus in age-related control groups
    Wiltrud Coerdt
    Department of Paediatric Pathology, Johannes Gutenberg University Hospital, 55101, Mainz, Germany
    Virchows Arch 444:239-46. 2004
    ..serve as histopathological criteria for a bowel motility disorder called intestinal neuronal dysplasia of the submucous plexus (IND B)...
  81. doi Identification and location of the cocaine and amphetamine regulated transcript (CART) in the abomasum of cattle
    Izabela Janiuk
    Department of Vertebrate Morphology, Siedlce University of Natural Sciences and Humanities, Prusa 14 str, 08 110 Siedlce, Poland
    Acta Histochem 115:371-5. 2013
    ..innervating the myocytes of the myenteron, neuroendocrine cells of the diffuse neuroendocrine system and the submucous plexus. The preliminary stage of abomasal CART detection suggests that CART is an agent that strongly affects the ..
  82. doi Long-term follow up of abdominal rectosigmoidectomy with posterior end-to-side stapled anastomosis for Chagas megacolon
    S C Nahas
    Division of Colorectal Surgery, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Colorectal Dis 13:317-22. 2011
    ..Megacolon is the most frequent long-term complication, caused by damage to the myoenteric and submucous plexus, ultimately leading to a functional barrier to the faeces...
  83. ncbi Direct synaptic contacts on the myenteric ganglia of the rat stomach from the dorsal motor nucleus of the vagus
    Tetsu Hayakawa
    Department of Anatomy, Hyogo College of Medicine, Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    J Comp Neurol 498:352-62. 2006
    The myenteric ganglia regulate not only gastric motility but also secretion, because a submucous plexus is sparsely developed in the rodent stomach...
  84. ncbi Mapping 5-HT inputs to enteric neurons of the guinea-pig small intestine
    K B Neal
    Department of Physiology, University of Melbourne, Medical Building, Parkville, Victoria 3052, Australia
    Neuroscience 145:556-67. 2007
    ..Taken together these results suggest that neural 5-HT may have significant roles in excitatory pathways regulating both motility and secretion...
  85. ncbi Diabetes mellitus is associated with a decrease in vasoactive intestinal polypeptide content of gastrointestinal tract of rat
    E Adeghate
    Department of Human Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Arch Physiol Biochem 109:246-51. 2001
    ..A low tissue level of VIP in the gastroduodenal tract of diabetic rat may contribute in part to the abnormal gut motility observed in diabetic patients...
  86. ncbi Neurocalcin-alpha immunoreactivity in the enteric nervous system of young and aged rats
    R A Corns
    School of Biosciences, University of Wales Cardiff, Cardiff, UK
    Cell Calcium 31:53-8. 2002
    ..Semiquantitative estimates revealed fewer NC-ir neurons in the submucous plexus than in the myenteric plexus. The greatest occurrence of NC-ir neurons was in the small and large intestine...
  87. ncbi Expression of a functional metabotropic glutamate receptor 5 on enteric glia is altered in states of inflammation
    Yasmin Nasser
    Institute for Infection, Immunity and Inflammation, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Glia 55:859-72. 2007
    ..Our data suggest that enteric glia are a functional target of the glutamatergic neurotransmitter system in the ENS and that changes in mGluR5 expression may be of physiological significance during colitis...
  88. pmc Intraepithelial lymphocytes, goblet cells and VIP-IR submucosal neurons of jejunum rats infected with Toxoplasma gondii
    Débora M G Sant'ana
    Universidade Estadual de Maringa, Maringa, Brazil
    Int J Exp Pathol 93:279-86. 2012
    ..Infection with T. gondii caused alterations in the chemical composition of the intestinal mucous and reduction in the neuron number and atrophy of the remaining neurons in this cell subpopulation...
  89. ncbi Morphological relationships between peptidergic nerve fibers and immunoglobulin A-producing lymphocytes in the mouse intestine
    Maiko Shibata
    Department of Neuroanatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Brain Behav Immun 22:158-66. 2008
    ....
  90. ncbi Human submucosal neurones regulate intestinal epithelial cell proliferation: evidence from a novel co-culture model
    F Toumi
    INSERM U539, Faculte de Medecine, Nantes, France
    Neurogastroenterol Motil 15:239-42. 2003
    ..In conclusion, our study suggests that the human ENS is involved in the control of epithelial cell proliferation...
  91. pmc Mechanisms underlying presynaptic inhibition through alpha 2-adrenoceptors in guinea-pig submucosal neurones
    K Z Shen
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Physiol 431:609-28. 1990
    ....
  92. ncbi Morphologies and projections of defined classes of neurons in the submucosa of the guinea-pig small intestine
    John B Furness
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, VIC 3010, Australia
    Anat Rec A Discov Mol Cell Evol Biol 272:475-83. 2003
    ..It is concluded that each functionally defined type of submucosal neuron has a characteristic morphology and that intrinsic primary afferent neurons synapse with secretomotor neurons to form monosynaptic secretomotor reflex circuits...
  93. doi Differentiation of interstitial cells of Cajal in the human distal colon
    Goran Radenkovic
    Department of Histology and Embryology, Faculty of Medicine, University of Nis, Nis, Serbia
    Cells Tissues Organs 196:463-9. 2012
    ..at weeks 10-11 of the fetal period in the form of two parallel belts of densely packed cells extending at the submucous plexus (SMP) and the MP level. These cells correspond to ICC of the SMP (ICC-SMP) and ICC of the MP (ICC-MP)...
  94. ncbi Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Cell Tissue Res 311:277-87. 2003
    ....
  95. doi Changes in the somatostatin (SOM)-like immunoreactivity within nervous structures of the porcine descending colon under various pathological factors
    Sławomir Gonkowski
    Division of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Exp Mol Pathol 88:416-23. 2010
    ..The obtained results suggest that SOM-LI nerve structures of the ENS may participate in various pathological states within the porcine descending colon and their functions probably depend on the type of pathological factor...
  96. ncbi Colocalization of NO and VIP in neurons of the submucous plexus in the rat intestine
    Yoshihide Chino
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Peptides 23:2245-50. 2002
    ..enhance the immunoreactivity and examined the colocalization of NO synthase (nNOS) and VIP in neurons of the submucous plexus throughout the rat digestive tract...
  97. doi Ca(2+) transients in submucous neurons during the colonic migrating motor complex in the isolated murine large intestine
    T Okamoto
    Department of Cell Biology and Physiology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Neurogastroenterol Motil 24:769-78, e354. 2012
    ..Our aim was to determine whether submucous neurons were also activated during the CMMC...
  98. doi Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse
    Peter J Wookey
    Department of Medicine at Austin Health, University of Melbourne, Parkville, VIC 3010, Australia
    Cell Tissue Res 347:311-7. 2012
    ..The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons. Signals may reach enteric neurons in milk, which contains high levels of calcitonin...
  99. pmc Activity of protease-activated receptors in primary cultured human myenteric neurons
    Eva M Kugler
    Human Biology, Technische Universität München Freising, Germany
    Front Neurosci 6:133. 2012
    ..recently demonstrated that, unlike in rodents, PAR1 is the dominant neuronal protease receptor in the human submucous plexus. With this study we investigated whether this also applies to the human myenteric plexus...
  100. ncbi Histopathological differences between recto-sigmoid Hirschsprung's disease and total colonic aganglionosis
    V Solari
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College, Dublin 12, Ireland
    Pediatr Surg Int 19:349-54. 2003
    ..and control patients there was a strong nNOS and peripherin immunoreactivity (IR) in ganglia of myenteric and submucous plexus and in thin nerve fibres in the muscle layers...
  101. ncbi The distribution of P2X5 purinergic receptors in the enteric nervous system of mouse
    Huai Zhen Ruan
    Department of Neurobiology, Third Military Medical University, Chongqing, 400038, China
    Cell Tissue Res 319:191-200. 2005
    ..In the submucous plexus, P2X(5) receptor immunoreactivity occurred throughout the cytoplasm and on the surface membranes of the nerve ..

Research Grants63

  1. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  2. NEURAL CONTROL OF LARGE INTESTINAL MUCOSA
    Helen Cooke; Fiscal Year: 1993
    ..The first aim addresses the efferent pathways in the submucous plexus that mediate histamine-evoked cyclical secretion in normal animals...
  3. MULTIPLE SITE OPTICAL RECORDING OF MEMBRANE POTENTIAL
    BRIAN SALZBERG; Fiscal Year: 2003
    ..study of a quasi-2- dimensional nervous system that is uniquely amenable to analysis by optical means, the submucous plexus of the guinea-pig small intestine...
  4. ADENOSINE DERIVATIVES AND TRANSMITTER RELEASE
    EUGENE SILINSKY; Fiscal Year: 1993
    ..stimulatory effect of adenosine will be studied at mammalian motor nerve terminals and at nerve endings in submucous plexus of the mammalian enteric nervous system...
  5. MULTIPLE SITE OPTICAL RECORDING OF MEMBRANE POTENTIAL
    BRIAN SALZBERG; Fiscal Year: 2000
    ..the neurons in a mammalian simple nervous system that is uniquely amenable to analysis by optical means, the submucous plexus of the Guinea-pig ileum, and adapt a novel analytical tool (the gravitational transformation) to the task of ..
  6. Enteric Nervous System 2003
    Keith Sharkey; Fiscal Year: 2003
    ..From this picture there will be gaps - these are the challenges for the future. ..
  7. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS CHRISTOFI; Fiscal Year: 2005
    ..Integrating such information provides new insights on the role of purinergic receptors on afferent and motor neurons in enteric neural reflexes and motility. ..
  8. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS CHRISTOFI; Fiscal Year: 2007
    ..These mechanistic studies will provide new insights into A3R regulation as a therapeutic target in experimental models of lBD and may pave the way towards translational studies. ..
  9. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2007
    ..framework of how the different psychological processes involved in food reward are neurologically organized, and (3) the development of pharmacological and behavioral therapeutic tools to counteract "common" obesity in a world of plenty ..
  10. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..
  11. Neural mechanisms controlling food intake and body weight after bariatric surgery
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..This will result in more optimal surgical procedures, behavioral tips helping patients to cope with different eating habits, and development of new drugs. ..
  12. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS CHRISTOFI; Fiscal Year: 2010
    ..These mechanistic studies willprovide new insights into A3R regulation as a therapeutic target in experimental models oflBD and may pave the way towards translational studies. ..
  13. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2007
    ..abstract_text> ..
  14. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2002
    ....