neuropil

Summary

Summary: A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.

Top Publications

  1. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
  2. pmc The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging
    Iván J Cajigas
    Max Planck Institute for Brain Research, Max von Laue Strasse 3, Frankfurt am Main 60438, Germany
    Neuron 74:453-66. 2012
  3. ncbi The accessory olfactory bulb in the adult rat: a cytological study of its cell types, neuropil, neuronal modules, and interactions with the main olfactory system
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, CP 76001 Qro, Mexico
    J Comp Neurol 510:309-50. 2008
  4. pmc Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation
    Robert W Taylor
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37205, USA
    J Neurosci 31:9869-78. 2011
  5. pmc Ultrastructural analysis of hippocampal neuropil from the connectomics perspective
    Yuriy Mishchenko
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
    Neuron 67:1009-20. 2010
  6. ncbi Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor
    Marco Gessi
    Division of Neuropathology, IRCCS Neurological Inst C Besta, Milan, Italy
    Am J Surg Pathol 33:211-7. 2009
  7. pmc Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease
    Geoffrey A Kerchner
    Stanford Center for Memory Disorders, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroimage 63:194-202. 2012
  8. ncbi Neuronal organization of the hemiellipsoid body of the land hermit crab, Coenobita clypeatus: correspondence with the mushroom body ground pattern
    Gabriella Wolff
    Department of Neuroscience, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 520:2824-46. 2012
  9. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
  10. ncbi Early development of the Drosophila brain: III. The pattern of neuropile founder tracts during the larval period
    Claude Nassif
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:417-34. 2003

Detail Information

Publications234 found, 100 shown here

  1. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
    ..generates different leg motoneuron subtypes, starting with those innervating proximal targets and medial neuropil regions and producing progeny that innervate distal muscle targets and lateral neuropil later in the lineage...
  2. pmc The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging
    Iván J Cajigas
    Max Planck Institute for Brain Research, Max von Laue Strasse 3, Frankfurt am Main 60438, Germany
    Neuron 74:453-66. 2012
    ..Here, we use deep sequencing to identify the mRNAs resident in the synaptic neuropil in the hippocampus...
  3. ncbi The accessory olfactory bulb in the adult rat: a cytological study of its cell types, neuropil, neuronal modules, and interactions with the main olfactory system
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, CP 76001 Qro, Mexico
    J Comp Neurol 510:309-50. 2008
    ..The second layer, or glomerular layer, is also divided by a conspicuous invagination of the neuropil of the ECL at the junction of the rostral and caudal halves...
  4. pmc Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation
    Robert W Taylor
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37205, USA
    J Neurosci 31:9869-78. 2011
    ..The habenular nuclei of zebrafish are robustly asymmetric, with dense elaboration of neuropil only in the left lateral subnucleus...
  5. pmc Ultrastructural analysis of hippocampal neuropil from the connectomics perspective
    Yuriy Mishchenko
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
    Neuron 67:1009-20. 2010
    ..Thus, it will be difficult to predict synaptic connectivity using data sets missing ultrastructural details that distinguish between axo-dendritic touches and bona fide synapses...
  6. ncbi Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor
    Marco Gessi
    Division of Neuropathology, IRCCS Neurological Inst C Besta, Milan, Italy
    Am J Surg Pathol 33:211-7. 2009
    ..histologic features of ependymoblastoma and neuroblastoma, a lesion referred to as "embryonal tumor with abundant neuropil and true rosettes" (ETANTR)...
  7. pmc Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease
    Geoffrey A Kerchner
    Stanford Center for Memory Disorders, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroimage 63:194-202. 2012
    ..These findings highlight a role for 7T hippocampal microstructural imaging in revealing focal structural pathology that correlates with the central cognitive feature of AD...
  8. ncbi Neuronal organization of the hemiellipsoid body of the land hermit crab, Coenobita clypeatus: correspondence with the mushroom body ground pattern
    Gabriella Wolff
    Department of Neuroscience, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 520:2824-46. 2012
    ..We conclude that crustaceans, insects, and other groups of arthropods share an ancestral neuronal ground pattern that is specific to their second-order olfactory centers...
  9. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
    ..detection of antibodies to cell surface or synaptic proteins demonstrated that six patients had antibodies to the neuropil of hippocampus or cerebellum, and one to intraneuronal antigens...
  10. ncbi Early development of the Drosophila brain: III. The pattern of neuropile founder tracts during the larval period
    Claude Nassif
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:417-34. 2003
    ..These models form part of our effort to generate an anatomic framework of Drosophila larval brain structure required for accurate localization of gene expression and gene function in experimental studies of neural development...
  11. ncbi Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Neurobiol 41:189-207. 1999
    The central complex is an important center for higher-order brain function in insects. It is an intricate neuropil composed of four substructures...
  12. pmc Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil
    Justin P Kinney
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 521:448-64. 2013
    Although the extracellular space in the neuropil of the brain is an important channel for volume communication between cells and has other important functions, its morphology on the micron scale has not been analyzed quantitatively owing ..
  13. ncbi F-actin at identified synapses in the mushroom body neuropil of the insect brain
    Ina Frambach
    Institut fur Zoologie, Anthropologie und Entwicklungsbiologie, University of Gottingen, 37073 Gottingen, Germany
    J Comp Neurol 475:303-14. 2004
    ..The accumulation of f-actin in KC dendrites is discussed in view of mushroom body plasticity and its potential role in learning and memory formation...
  14. ncbi Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes
    Sumihito Nobusawa
    Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Brain Pathol 22:689-97. 2012
    Recently, it was reported that ependymoblastoma and embryonal tumor with abundant neuropil and true rosettes (ETANTR) show 19q13.42 amplification at a high frequency, suggesting that these tumors may constitute a single entity...
  15. pmc Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex
    Omer Ali Bayraktar
    Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Neural Dev 5:26. 2010
    ..In addition, we use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory...
  16. ncbi Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation
    Anna Maria Buccoliero
    Department of Biomedicine, Careggi Hospital, 50134 Florence, Italy
    Neuropathology 30:84-91. 2010
    ..Embryonal tumor with abundant neuropil and true rosettes is a recently recognized rare tumor...
  17. ncbi Structure of the mushroom bodies of the insect brain
    Susan E Fahrbach
    Department of Biology, Wake Forest University, Winston Salem, North Carolina, 27109, USA
    Annu Rev Entomol 51:209-32. 2006
    ..Two topics are highlighted: the volume plasticity of mushroom body neuropils evident in the brains of some adult insects and a possible essential role for the gamma lobe in olfactory memory...
  18. ncbi Immunolocalisation of crustacean-SIFamide in the median brain and eyestalk neuropils of the marbled crayfish
    M A Polanska
    Institute of Infectious Diseases, Medical University of Warsaw, Warsaw, 02 106, Poland
    Cell Tissue Res 330:331-44. 2007
    ..Taken together, we suggest an important role of crustacean-SIFamidergic neurons in processing high-order, multimodal input in the crayfish brain...
  19. ncbi Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropil
    T Kamiryo
    Department of Neurological Surgery, University of Virginia, Charlottesville 22908, USA
    Neurosurgery 49:409-14; discussion 414-5. 2001
    ..These results indicate that substantial changes in the neuropil do not occur 2 weeks before the time of definite necrosis formation, whereas changes in the basement membrane are ..
  20. ncbi Synaptic organization of the mushroom body calyx in Drosophila melanogaster
    Kouji Yasuyama
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 445:211-26. 2002
    The calyx neuropil of the mushroom body in adult Drosophila melanogaster contains three major neuronal elements: extrinsic projection neurons, presumed cholinergic, immunoreactive to choline acetyltransferase (ChAT-ir) and vesicular ..
  21. ncbi Embryonal tumor with abundant neuropil and true rosettes (ETANTR): a new distinctive variety of pediatric PNET: a case-based update
    Belen Ferri Niguez
    Service of Pathology, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, Spain
    Childs Nerv Syst 26:1003-8. 2010
    ..A distinctive subtype of PNET called "embryonal tumor with abundant neuropil and true rosettes" (ETANTR) was reported in 2000.
  22. pmc Cellular requirements for building a retinal neuropil
    Owen Randlett
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Cell Rep 3:282-90. 2013
    How synaptic neuropil is formed within the CNS is poorly understood. The retinal inner plexiform layer (IPL) is positioned between the cell bodies of amacrine cells (ACs) and retinal ganglion cells (RGCs)...
  23. ncbi Embryonal tumors with abundant neuropil and true rosettes: 2 illustrative cases and a review of the literature
    Sunil Manjila
    Division of Pediatric Neurosurgery, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Neurosurg Focus 30:E2. 2011
    Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a recently identified variant of primitive neuroectodermal tumor, with fewer than 50 cases reported in the literature to date...
  24. ncbi Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*
    Alexander R Judkins
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Pathol 20:133-9. 2010
    ..feature and were present in 11/14 (79%) tumors, eight (73%) of which were embryonal tumors with abundant areas of neuropil-like differentiation...
  25. pmc APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory
    Geoffrey A Kerchner
    From the Departments of Neurology and Neurological Sciences G A K, D B, J C S, J D B, M C F, G K D, T W C and Radiology B K R, Stanford University School of Medicine, Stanford and Center for Tissue Regeneration, Repair and Restoration T W C, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA
    Neurology 82:691-7. 2014
    ..Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory...
  26. ncbi 3D segmentation of SBFSEM images of neuropil by a graphical model over supervoxel boundaries
    Bjoern Andres
    HCI, University of Heidelberg, Speyerer Str 6, D 69115 Heidelberg, Germany
    Med Image Anal 16:796-805. 2012
    The segmentation of large volume images of neuropil acquired by serial sectioning electron microscopy is an important step toward the 3D reconstruction of neural circuits...
  27. pmc The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil
    Simon G Sprecher
    Institute of Developmental and Cell Biology, Department of Biology, University of Fribourg, Chemin du Musee 10, 1700, Fribourg, Switzerland
    Dev Biol 358:33-43. 2011
    ..The visual system of the fruit fly larva represents a simple visual system (larval optic neuropil, LON) that consists of 12 PRs falling into two classes: blue-senstive PRs expressing Rhodopsin 5 (Rh5) and green-..
  28. pmc The clock input to the first optic neuropil of Drosophila melanogaster expressing neuronal circadian plasticity
    Milena Damulewicz
    Department of Cell Biology and Imaging, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 6:e21258. 2011
    In the first optic neuropil (lamina) of the fly's visual system, two interneurons, L1 and L2 monopolar cells, and epithelial glial cells show circadian rhythms in morphological plasticity...
  29. ncbi Neuronal intranuclear and neuropil inclusions for pathological assessment of Huntington's disease
    Marion Maat-Schieman
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Brain Pathol 17:31-7. 2007
    To evaluate the usefulness of neuronal intranuclear inclusions and neuropil inclusions for the pathological assessment of Huntington's disease (HD), their presence in neocortex was assessed by ubiquitin and N-terminal huntingtin ..
  30. ncbi A novel octopamine receptor with preferential expression in Drosophila mushroom bodies
    K A Han
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 18:3650-8. 1998
    ..analysis using an antibody made to the receptor revealed highly enriched expression in the mushroom body neuropil and the ellipsoid body of central complex, brain areas known to be crucial for olfactory learning and motor ..
  31. ncbi Neuronal architecture of the mosquito deutocerebrum
    Rickard Ignell
    Division of Chemical Ecology, Department of Crop Science, Swedish University of Agricultural Sciences, SE 23053 Alnarp, Sweden
    J Comp Neurol 493:207-40. 2005
    ..Within the antennal nerve a specific neuropil containing early, bouton-like ramifications of receptor neurons is described...
  32. pmc Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia
    R O Kuljis
    Department of Neurology, University of Miami, Miami, FL 33136 2115, USA
    Proc Natl Acad Sci U S A 94:12688-93. 1997
    ..cerebellar cortex of 2-month-old Atm knockout mice, which is accompanied by glial activation, deterioration of neuropil structure, and both pre- and postsynaptic degeneration...
  33. ncbi Regulation of radial glial motility by visual experience
    Marc Tremblay
    McGill Graduate Program in Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:14066-76. 2009
    ..Structurally, radial glia extended and retracted many filopodial processes within the tectal neuropil over minutes...
  34. ncbi Octopamine-like immunoreactivity in the honey bee and cockroach: comparable organization in the brain and subesophageal ganglion
    Irina Sinakevitch
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 488:233-54. 2005
    ..The present observations are discussed with respect to possible roles of octopamine in sensory integration and association...
  35. ncbi A systematic random sampling scheme optimized to detect the proportion of rare synapses in the neuropil
    Nuno Maçarico da Costa
    Institute for Neuroinformatics, University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Neurosci Methods 180:77-81. 2009
    ..When quantitative estimates are required for pathways that contribute a small proportion of synapses to the neuropil, the problems of accurate sampling are particularly severe and the total time required may become prohibitive...
  36. pmc Brain organization and the origin of insects: an assessment
    Nicholas James Strausfeld
    Division of Neurobiology and The Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Biol Sci 276:1929-37. 2009
    ..Neural organization in brain centres, comprising olfactory pathways, optic lobes and a central neuropil that is thought to play a cardinal role in multi-joint movement, support affinities between insects and ..
  37. ncbi A cytological and experimental study of the neuropil and primary olfactory afferences to the piriform cortex
    Víctor Vargas-Barroso
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Qro, Mexico
    Anat Rec (Hoboken) 296:1297-316. 2013
    ..In rapid-Golgi specimens a set of collaterals from the lateral olfactory tract (i.e., sublayer Ia) to the neuropil of the Layer II (LII) was identified...
  38. ncbi Embryonal tumor with abundant neuropil and true rosettes: a report of three cases of a rare tumor, with an unusual case showing rhabdomyoblastic and melanocytic differentiation
    Maysa Al-Hussaini
    Department of Pathology, King Hussein Cancer Center KHCC, Amman, Jordan
    Neuropathology 31:620-5. 2011
    Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is an increasingly recognized entity that belongs to the family of embryonal tumors of the CNS...
  39. ncbi Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with a focal amplification at chromosome 19q13.42 locus: further evidence of two new instances in China
    Yin Wang
    Department of Neuropathology, Institute of Neurology and Huashan Hospital of Fudan University, Shanghai, China
    Neuropathology 31:639-47. 2011
    Recently, the term "embryonal tumor with multilayered rosettes" (ETMR), including embryonal tumor with abundant neuropil and true rosettes (ETANTR) and ependymoblastoma (EBL) as a distinct tumor entity, has become an important topic of ..
  40. pmc Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT)
    Jennifer J L Hodas
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Proteomics 12:2464-76. 2012
    ..enrichment, and MS-based identification of candidate proteins specifically translated in intact hippocampal neuropil sections upon treatment with the selective D1/D5 receptor agonist SKF81297...
  41. pmc Serotonin immunoreactive interneurons in the brain of the Remipedia: new insights into the phylogenetic affinities of an enigmatic crustacean taxon
    Torben Stemme
    Division of Cell Biology, University of Veterinary Medicine Hannover, Hannover, Germany
    BMC Evol Biol 12:168. 2012
    ..This approach allows for a comprehensive neuroanatomical comparison with other crustacean and hexapod taxa...
  42. pmc Embryonal tumor with abundant neuropil and true rosettes: an autopsy case-based update and review of the literature
    Dariusz Adamek
    Department of Neuropathology, Jagiellonian University Medical College, ul Grzegorzecka 16, Krakow, Poland
    Childs Nerv Syst 29:849-54. 2013
    Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a rare subtype of primitive neuroectodermal tumors first reported in 2000...
  43. ncbi Circadian expression of the presynaptic active zone protein Bruchpilot in the lamina of Drosophila melanogaster
    Jolanta Górska-Andrzejak
    Department of Cell Biology and Imaging, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Dev Neurobiol 73:14-26. 2013
    ..In the present study we show that in the first optic neuropil (lamina) of Drosophila melanogaster, a presynaptic active zone protein Bruchpilot (BRP) exhibits a circadian ..
  44. ncbi Spinal cord glioneuronal tumor with neuropil-like islands with 1p/19q deletion in an adult with low-grade cerebral oligodendroglioma
    Tyler J Fraum
    Neuro Oncology Branch, National Institutes of Health, 9030 Old Georgetown Rd, Room 221, Bethesda, MD 20892 8202, USA
    J Neurooncol 107:421-6. 2012
    Glioneuronal tumor with neuropil-like islands (GTNI) is considered a rare variant of astrocytoma, characterized by discrete aggregates of cells expressing neuronal markers that punctuate a GFAP-positive glial background...
  45. ncbi NADPH-diaphorase histochemical labeling patterns in the hippocampal neuropil and visual cortical neurons in weaned rats reared during lactation on different litter sizes
    Ana Paula Rocha-de-Melo
    Departamento de Nutricao, Universidade Federal de Pernambuco, BR 50670 901, Recife, PE, Brazil
    Nutr Neurosci 7:207-16. 2004
    ..We assessed morphometric features of the diaphorase-positive cells in visual cortex, and the neuropil histochemical activity in hippocampal CA1 and dentate gyrus using densitometry analysis...
  46. pmc Comparative analysis of deutocerebral neuropils in Chilopoda (Myriapoda): implications for the evolution of the arthropod olfactory system and support for the Mandibulata concept
    Andy Sombke
    Ernst Moritz Arndt University of Greifswald, Zoological Institute and Museum, Cytology and Evolutionary Biology, 17487 Greifswald, Germany
    BMC Neurosci 13:1-17. 2012
    ....
  47. ncbi Embryonal tumor with abundant neuropil and true rosettes. A new entity or only variations of a parent neoplasms (PNETs)? This is the dilemma
    M La Spina
    Division of Hematology Oncology, Department of Pediatrics, Catania University Hospital, Catania, Sicily, Italy
    J Neurooncol 78:317-20. 2006
    ..at the pons and mesencephalon, has been histologically classified as an embryonal tumor containing abundant neuropil and true rosettes...
  48. ncbi Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation
    Christopher Dunham
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box, 8118, St Louis, MO 63110, USA
    J Neurooncol 84:91-8. 2007
    ..one year later, and tissue from that resection proved to be diagnostic for an embryonal tumor with abundant neuropil and true rosettes (ETANTR)...
  49. pmc Distribution of extracellular glutamate in the neuropil of hippocampus
    Melissa A Herman
    Vollum Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e26501. 2011
    ..We suggest that, in the CA1 region of hippocampus, glutamate transporters do not create a privileged space within the synapse but rather keep ambient glutamate at very low levels throughout the neuropil.
  50. pmc Arborization pattern of engrailed-positive neural lineages reveal neuromere boundaries in the Drosophila brain neuropil
    Abhilasha Kumar
    Biozentrum, University of Basel, Basel, Switzerland
    J Comp Neurol 517:87-104. 2009
    ..complex structure composed of thousands of neurons that are interconnected in numerous exquisitely organized neuropil structures such as the mushroom bodies, central complex, antennal lobes, and other specialized neuropils...
  51. ncbi Glomerular cytoarchitectures in chemosensory systems of arachnids
    P H Brownell
    Department of Zoology, Oregon State University, Corvallis 97331 2914, USA
    Ann N Y Acad Sci 855:502-7. 1998
    In most animals the central pathways of olfactory systems are associated with glomerular neuropil and lack topographic mapping of sensory inputs...
  52. ncbi Time course changes of the striatum neuropil after unilateral dopamine depletion and the usefulness of the contralateral striatum as a control structure
    MaríaRosa Avila-Costa
    Departamento de Neurociencias, Facultad de Estudios Superiores Iztacala, UNAM, Mexico City, Mexico
    Neurol Res 30:1068-74. 2008
    ..After unilateral dopamine depletion, some ipsilateral alterations occur and the contralateral structure has been utilized as control...
  53. pmc Circadian control of dendrite morphology in the visual system of Drosophila melanogaster
    Paweł Weber
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 4:e4290. 2009
    In the first optic neuropil (lamina) of the fly's visual system, monopolar cells L1 and L2 and glia show circadian rhythms in morphological plasticity. They change their size and shape during the day and night...
  54. ncbi Organization and postembryonic development of glial cells in the adult central brain of Drosophila
    Takeshi Awasaki
    Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts 01605, USA
    J Neurosci 28:13742-53. 2008
    ..It lays an essential foundation for studying glia development and function in the Drosophila brain...
  55. pmc Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
    Chuan En Wang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 181:803-16. 2008
    ..However, the contribution of cytoplasmic mutant huntingtin and its aggregates in neuronal processes (neuropil aggregates) has not been rigorously explored...
  56. ncbi Organization of deutocerebral neuropils and olfactory behavior in the centipede Scutigera coleoptrata (Linnaeus, 1758) (Myriapoda: Chilopoda)
    Andy Sombke
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll Straße 8, 07745 Jena, Germany
    Chem Senses 36:43-61. 2011
    ..These results are in line with the morphological findings concerning the well-developed olfactory centers in the deutocerebrum of this species...
  57. ncbi Evolution of the central complex in the arthropod brain with respect to the visual system
    Uwe Homberg
    Fachbereich Biologie, Tierphysiologie, Philipps Universitat Marburg, Karl von Frisch Strass8, D 35032 Marburg, Germany
    Arthropod Struct Dev 37:347-62. 2008
    ..In insects and crayfish, the central body is connected to a second midline-spanning neuropil, the protocerebral bridge. Both structures are collectively termed central complex...
  58. ncbi Organization of the honey bee mushroom body: representation of the calyx within the vertical and gamma lobes
    Nicholas J Strausfeld
    Division of Neurobiology, Arizona Research Laboratories, The University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 450:4-33. 2002
    ..The present findings suggest the need for critical reinterpretation of studies that have been predicated on early descriptions of the mushroom body's lobes...
  59. pmc An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction
    David E Featherstone
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Neurosci 25:3199-208. 2005
    ..GluRIID is expressed in the postsynaptic domain of the NMJ, as well as widely throughout the synaptic neuropil of the CNS...
  60. ncbi Dual olfactory pathway in the honeybee, Apis mellifera
    Sebastian Kirschner
    Department of Behavioral Physiology and Sociobiology, Biozentrum, University of Wurzburg, Wurzburg, Germany
    J Comp Neurol 499:933-52. 2006
    ..The results indicate that olfactory input in the honeybee is processed via two separate, mainly uPN pathways to the MB calyx and LH and several pathways to the lateral protocerebrum...
  61. ncbi Comparative morphology of central neuropils in the brain of arthropods and its evolutionary and functional implications
    R Loesel
    Department of Developmental Biology and Morphology of Animals, Institute of Biology II, RWTH Aachen, Kopernikusstr 16, D 52056 Aachen, Germany
    Acta Biol Hung 55:39-51. 2004
    ..suggesting that central complexes in both groups are homologous structures derived from a basal ancestral neuropil. This ancestral archetype of the central complex (lacking the protocerebral bridge) might be represented in the ..
  62. ncbi Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice
    S J Tallaksen-Greene
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroscience 131:843-52. 2005
    We studied the development of neuronal intranuclear inclusions (NIIs), neuropil aggregates (NAs), and expression of expanded repeat polyglutamine protein in the HdhCAG(150) knockin mouse model of Huntington's disease (HD)...
  63. ncbi Transition from marine to terrestrial ecologies: changes in olfactory and tritocerebral neuropils in land-living isopods
    S Harzsch
    Universitat Greifswald, Fachbereich Biologie, Abteilung Cytologie und Evolutionsbiologie, J S Bach Strasse 11 12, D 17498 Greifswald, Germany
    Arthropod Struct Dev 40:244-57. 2011
    ..Evidence suggests that Isopoda have evolved, and are in the process of evolving, several novel solutions to chemical perception on land and in air...
  64. pmc Structural plasticity of circuits in cortical neuropil
    Gina Escobar
    Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA
    J Neurosci 28:8477-88. 2008
    ..New synaptic contacts appear in the neuropil where the gaps between axonal and dendritic branches can be bridged by dendritic spines...
  65. ncbi Neuropil reactivity, distribution and morphology of NADPH diaphorase type I neurons in the barrel cortex of the adult mouse
    Marco Aurelio M Freire
    Laboratory of Functional Neuroanatomy, Department of Morphology, Biological Sciences Building, Federal University of Para, Belem, PA, Brazil
    J Chem Neuroanat 30:71-81. 2005
    ..work, we studied both the distribution and morphology of neurons stained for NADPH diaphorase (NADPH-d) and neuropil reactivity in the posteromedial barrel subfield (PMBSF), which represents the mystacial whiskers...
  66. ncbi Ecological, evolutionary, and functional correlates of sensilla number and glomerular density in the olfactory system of decapod crustaceans
    Barbara S Beltz
    Department of Biological Sciences, Wellesley College, Wellesley, Massachusetts 02481, USA
    J Comp Neurol 455:260-9. 2003
    ..and invertebrate species is the division of the primary processing area into distinct clumps of synaptic neuropil, called glomeruli...
  67. ncbi Glioneuronal tumor with neuropil-like islands of the spinal cord with diffuse leptomeningeal neuraxis dissemination
    Bree Ruppert
    Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA
    J Neurooncol 104:529-33. 2011
    ..Histology revealed a WHO grade III glioneuronal tumor with rosetted neuropil-like islands...
  68. ncbi Development of nitrergic neurons in the nervous system of the locust embryo
    Michael Stern
    Cell Biology, Institute of Physiology, University of Veterinary Medicine Hannover, D 30173 Hannover, Germany
    J Comp Neurol 518:1157-75. 2010
    ..For the CNS, histochemical markers for NOS do not provide conclusive evidence for a developmental role of this enzyme...
  69. pmc Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
    G A Kerchner
    Stanford Center for Memory Disorders, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Neurology 75:1381-7. 2010
    ..Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial ..
  70. pmc Cyclical expression of Na+/K+-ATPase in the visual system of Drosophila melanogaster
    Jolanta Górska-Andrzejak
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow 30 060, Poland
    J Insect Physiol 55:459-68. 2009
    ..There, GFP expression occurs in medulla neuropil glia (MNGl), which express the clock gene per, and which closely contact the terminals of clock neurons ..
  71. ncbi Ordinary glomeruli in the antennal lobe of male and female tortricid moth Grapholita molesta (Busck) (Lepidoptera: Tortricidae) process sex pheromone and host-plant volatiles
    Nélia Varela
    Department of Crop Protection, Centre UdL IRTA, University of Lleida, Lleida, Spain
    J Exp Biol 214:637-45. 2011
    ..However, the absence of recorded pheromone responses in the Cu needs to be confirmed...
  72. ncbi Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications
    Marco Gessi
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy
    Acta Neuropathol 109:231-4. 2005
    We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting...
  73. ncbi Spinal cord glioneuronal tumor with "rosetted" neuropil islands and meningeal dissemination: a case report
    B T Harris
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Acta Neuropathol 100:575-9. 2000
    Distinctive glioneuronal tumors arising within the cerebrum and displaying neuropil-like islands and tumor cells immunoreactive for neuronal and glial antigens have recently been described...
  74. ncbi Innervation pattern of suboesophageal ventral unpaired median neurones in the honeybee brain
    Ulrike Schröter
    FB Biologie Chemie Pharmazie, Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Strasse 28 30, 14195 Berlin, Germany
    Cell Tissue Res 327:647-67. 2007
    ..In addition, we describe one labial unpaired median neurone with a dorsal cell body, DUMlb1. The possible homology between the honeybee VUM neurones and the unpaired median neurones in other insects is discussed...
  75. ncbi Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage
    Wayne Pereanu
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:5534-53. 2006
    ..Third, the atlas can serve as a repository for genes expressed in lineage-specific patterns...
  76. pmc Arthropod phylogeny: onychophoran brain organization suggests an archaic relationship with a chelicerate stem lineage
    Nicholas J Strausfeld
    Division of Neurobiology and The Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Biol Sci 273:1857-66. 2006
    ..Neuroanatomical evidence suggests that the organization of the onychophoran brain is similar to that of the brains of chelicerates...
  77. ncbi Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease
    C W Picanço-Diniz
    Universidade Federal do Para, Centro de Ciencias Biologicas, Departamento de Morfologia, Laboratório de Neuroanatomia Funcional, Belem, Brazil
    Neuropathol Appl Neurobiol 30:292-303. 2004
    ..and late stages after the initiation of the disease we assessed features of the NADPH-d positive cells and the neuropil histochemical activity in CA1 and dentate gyrus using densitometric analysis...
  78. ncbi Early development of the Drosophila brain: IV. Larval neuropile compartments defined by glial septa
    Amelia Younossi-Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:435-50. 2003
    ..Neuropile compartments, representing easily identifiable landmark structures, will assist in future analyses of Drosophila brain development in which the exact location of neurons and their axonal trajectories is of importance...
  79. ncbi Synaptic connections of cholinergic antennal lobe relay neurons innervating the lateral horn neuropile in the brain of Drosophila melanogaster
    Kouji Yasuyama
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 466:299-315. 2003
    ..The significance of the postsynaptic neurites of the ChAT PNs is discussed; either local or other interneurons might connect the ChAT PNs within the LH, or PNs might receive inputs arising from outside the LH...
  80. ncbi Early development of the Drosophila brain: V. Pattern of postembryonic neuronal lineages expressing DE-cadherin
    Karin Dumstrei
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:451-62. 2003
    ..The map of larval lineages and their axonal projection will be important for future studies on postembryonic neurogenesis in Drosophila. It also lays a groundwork for investigating the role of DE-cadherin in larval brain development...
  81. ncbi Embryonic origin of the Drosophila brain neuropile
    Amelia Younossi-Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 497:981-98. 2006
    ..This suggests that spatial information residing within neurons, rather than glial cells, specifies the location and initial shape of neuropile compartments...
  82. ncbi Expansion of the neuropil of the mushroom bodies in male honey bees is coincident with initiation of flight
    S E Fahrbach
    Department of Entomology, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Neurosci Lett 236:135-8. 1997
    ..There was an expansion of the neuropil of the MB that was temporally associated with drone behavioral development, as in female queens and workers...
  83. ncbi Reelin-immunoreactive neurons, axons, and neuropil in the adult ferret brain: evidence for axonal secretion of reelin in long axonal pathways
    Veronica Martinez-Cerdeno
    Neurodevelopment Laboratory, Department of Morphology, Autonoma University School of Medicine, E 28029 Madrid, Spain
    J Comp Neurol 463:92-116. 2003
    ..may be under the influence of Reelin, we systematically mapped Reelin-immunoreactive neuronal somata, axons, and neuropil in the brain and brainstem of ferrets...
  84. ncbi Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity
    Kirsten Hoffmann
    Department of Neurobiology, Institute of Zoology, Berliner Strasse 28, Gottingen, Germany
    Zoolog Sci 24:1028-35. 2007
    ..In addition, basal muscarinic excitation in the central body neuropil seems to determine the general motivation of a grasshopper to stridulate...
  85. ncbi Neurobiology of the basal platyhelminth Macrostomum lignano: map and digital 3D model of the juvenile brain neuropile
    Joshua Morris
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Genes Evol 217:569-84. 2007
    ..This study will aid in the documentation and interpretation of patterns of gene expression, as well as functional studies, in the developing Macrostomum brain...
  86. ncbi Synapse loss from chronically elevated glucocorticoids: relationship to neuropil volume and cell number in hippocampal area CA3
    Despina A Tata
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, New York 11790 2500, USA
    J Comp Neurol 498:363-74. 2006
    ..a comprehensive study of glucocorticoid effects on hippocampal CA3 volume and identified elements in the neuropil including astrocytic volume and cell and synapse number and size...
  87. ncbi Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain
    Thomas Rival
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, F 13288 Marseille Cedex 9, France
    Curr Biol 14:599-605. 2004
    ..glutamate transporter, dEAAT1, is selectively addressed to glial extensions that project ubiquitously through the neuropil close to synaptic areas...
  88. ncbi Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster
    Verónica G Rodriguez Moncalvo
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, ON, Canada
    Dev Biol 286:549-58. 2005
    ..These neurons send their axons in a fascicle, the larval optic nerve (LON), which terminates in the larval optic neuropil. The LON is required for the development of a serotonergic arborization originating in the central brain and for ..
  89. ncbi Compartmentalization of central neurons in Drosophila: a new strategy of mosaic analysis reveals localization of presynaptic sites to specific segments of neurites
    Robert Lohr
    Institute of Genetics, University of Mainz, D 55128 Mainz, Germany
    J Neurosci 22:10357-67. 2002
    ..This suggests that synaptogenic mechanisms in the CNS might differ from those at neuromuscular junctions...
  90. ncbi Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice
    H Li
    Department of Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 21:8473-81. 2001
    ..Here we report that in mice expressing full-length mutant huntingtin and modeling early stages of HD, neuropil aggregates form preferentially in the LGP and SN...
  91. ncbi Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes
    Federica Piccioni
    Institute of Endocrinology, Centre of Excellence for the Study and Treatment of Neurodegenerative Diseases, University of Milan, Milano, Italy
    FASEB J 16:1418-20. 2002
    ..Nuclear, cytoplasmic, or neuropil aggregates are detectable in CAG/polyGln-related diseases, but their role is still debated...
  92. pmc Hardwiring of fine synaptic layers in the zebrafish visual pathway
    Linda M Nevin
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Neural Dev 3:36. 2008
    ..Here we investigated two stratified areas of the zebrafish visual pathway, the inner plexiform layer (IPL) of the retina and the neuropil of the optic tectum, and determined if activity is required for their organization.
  93. ncbi Comparison of octopamine-like immunoreactivity in the brains of the fruit fly and blow fly
    Irina Sinakevitch
    Arizona Research Laboratories Division of Neurobiology, University of Arizona, Tucson, Arizona 85719, USA
    J Comp Neurol 494:460-75. 2006
    ..The results are also discussed with respect to recent studies on octopamine-immunoreactive organization in honey bees and cockroaches and the suggested roles of octopamine in sensory processing, learning, and memory...
  94. ncbi Histological and cytological study of the bed nuclei of the stria terminalis in adult rat. II. Oval nucleus: extrinsic inputs, cell types, neuropil, and neuronal modules
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, UNAM, Juriquilla, Zona Centro Querétaro, CP 76001 Querétaro, Mexico
    J Comp Neurol 497:772-807. 2006
    ..capsule, ventral amygdaloid pathway, and medial forebrain bundle are the main sources of afferents to the neuropil of the Ov...
  95. ncbi Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-Immunoreactive neuropil
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 113:45-55. 2009
    ..Alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders. Glutamic acid decarboxylase (GAD) is the key enzyme of GABA synthesis...
  96. pmc Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis
    Marta Zlatic
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000135. 2009
    ..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension...
  97. ncbi Conserved and convergent organization in the optic lobes of insects and isopods, with reference to other crustacean taxa
    I Sinakevitch
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 467:150-72. 2003
    ..However, in certain insects, the lobula is accompanied by a tectum-like fourth neuropil, the lobula plate, characterized by wide-field tangential neurons and linked to the medulla by uncrossed axons...
  98. ncbi Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    Liliana B Menalled
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 465:11-26. 2003
    ..These consisted of nuclear staining for huntingtin and huntingtin-containing nuclear and neuropil aggregates that first appeared in the striatum, nucleus accumbens, and olfactory tubercle...
  99. ncbi Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites
    Matthias Landgraf
    Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
    Dev Biol 260:207-25. 2003
    ..Using the Fasciclin2-based mapping procedure as a standard (e.g., in a common database) would facilitate studies on the functional architecture of the neuropile and the identification of candiate circuit elements...
  100. ncbi Stereotyped neuropil branching of an identified stomatogastric motor neuron
    Ann E Wilensky
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    J Comp Neurol 466:554-63. 2003
    Anatomical studies of the crab stomatogastric ganglion (STG) have suggested only minimal organization within the neuropil of this structure...
  101. ncbi Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregaria
    Angela E Kurylas
    Fachbereich Biologie, Tierphysiologie, , D 35032 Marburg, Germany
    J Comp Neurol 484:206-23. 2005
    ..About 470 neuronal cell bodies in the locust midbrain were NADPHd-positive positive, and nearly all major neuropil centers contained dense, sharply stained arborizations...

Research Grants65

  1. Glutamate-Glutamine Metabolism in Primary Human Brain Tumors
    Anne Williamson; Fiscal Year: 2010
    ..The death of surrounding normal neurons and glia allows the glioma to invade into the surrounding neuropil. However, the specific pathway(s) by which glutamate is synthesized from glutamine in glioma cells are not fully ..
  2. The Role of Connexin32 in the Pathogensis of CMTX
    STEVEN SIMON SCHERER; Fiscal Year: 2013
    ..Cx30 and Cx43 are required for the intracellular diffusion of a fluorescent glucose analogue (2-NDBG) to areas of neuropil with increased neuronal activity...
  3. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    ..changes in cortical GM FA reflect changes in the distribution of axonal and dendritic neuronal processes in the neuropil. This hypothesis stems from an analytical model that we recently developed to relate diffusion anisotropy in the ..
  4. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    Essential functions of central nervous system astrocytes include providing structural support to the neuropil and maintenance of extracellular neurotransmitter and ion concentrations...
  5. Role of Astrocyte Injury in Neuroprotection
    Martin A Philbert; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Astrocytes are an important component of the neuropil and their dysfunction has been associated with a variety of idiopathic and genetic diseases including Alzheimer's and Parkinson's ..
  6. A Sensory Map for Sulfated Steroids in the Accessory Olfactory Bulb
    Gary Hammen; Fiscal Year: 2013
    ..olfactory bulb, where axons from neurons expressing the same receptor type co-converge on small regions of neuropil called glomeruli...
  7. Advancing Gene Therapy for Late Infantile Neuronal Ceroid Lipofuscinosis
    Beverly L Davidson; Fiscal Year: 2013
    ..bypasses the BBB by engineering endothelial cells to secrete recombinant enzyme directly into the underlying neuropil. In order to advance this exciting and promising gene therapy approach to LINCL patients, elucidation of the ..
  8. Left-Right Asymmetry of the Developing Diecephalon
    Marnie E Halpern; Fiscal Year: 2013
    ..adjacent paired nuclei, the medial habenulae (Ha), which exhibit left-right differences in size, organization, neuropil density, and patterns of gene expression...
  9. Functional consequences of in vivo ablation of NG2 cells
    Dwight E Bergles; Fiscal Year: 2012
    ..in a grid-like manner in all gray and white matter regions, extend highly ramified processes into the surrounding neuropil, and form direct synapses with neurons, raising the possibility that they modulate the activity of neurons and ..
  10. Hippocampal Structure and Function in Cognitive Impairment
    GEOFFREY ALLEN KERCHNER; Fiscal Year: 2013
    ..Post-mortem studies reveal that specific subfields of the hippocampus, including the CA1 apical neuropil, develop pathology around the time that patients begin to experience early memory impairment...
  11. Cellular Structure of the Amygdala in Autism
    John T Morgan; Fiscal Year: 2011
    ..Another possible explanation is an increase in the space occupied by dendritic arbors and axons i.e. neuropil. However, the normal developmental course of dendritic arborization in the amygdala has not been established...
  12. Organization and Function of the Asymmetric Habenular Nuclei
    TAGIDE NOELIA DECARVALHO; Fiscal Year: 2013
    ..The right and left habenulae consist of two anatomically distinct nuclei and show pronounced differences in size, neuropil density and gene expression, but how this asymmetry relates to subnuclear organization is also unclear...
  13. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..Preliminary data show that baso-laterally (brain side) released Pf-IRBC medium directly activates the neuropil (astrocytes, neurons) by increasing GFAP expression...
  14. Characterizing the FASD cerebral cortex in utero with DTI
    Christopher D Kroenke; Fiscal Year: 2013
    ..latter will be accomplished by determining cerebral cortical cell numbers, measuring the volume fraction of the neuropil, and quantifying morphological complexity of cortical neuronal axonal and dendritic arbors...
  15. The role of Fat3 in amacrine cell dendrite development.
    Lisa V Goodrich; Fiscal Year: 2013
    ..and arrangement of their dendrites, with some neurons extending only one primary dendrite into a well-defined neuropil and others developing multiple dendrites that extend symmetrically about the cell body...
  16. Genetic Analysis of Nematode Behavior
    Scott W Emmons; Fiscal Year: 2013
    ..This neuropil contains the processes of 175 neurons connected by some 8000 synapses (4000 chemical, 4000 electrical)...
  17. Nitric Oxide Signaling in a Model Olfactory System
    Alan J Nighorn; Fiscal Year: 2010
    ..NO) expression has led to the hypothesis that NO mediates and/or modulates signaling within the primary olfactory neuropil. This idea has been strengthened by the observation that the hallmark spheroidal structures within the primary ..
  18. Cellular and Molecular Basis of Hippocampal Atrophy in Depressed Female Monkeys
    Carol A Shively; Fiscal Year: 2010
    ..monkeys to determine whether the smaller hippocampi of depressed female monkeys are accompanied by reductions in neuropil and synaptic, spinous, and dendritic integrity...
  19. Hemispheric Specialization and Communication
    William D Hopkins; Fiscal Year: 2013
    ..For these studies, we will Golgi stain post-mortem brain tissue and quantify both neuropil space and dendritic arborization for each region of interest in the left and right hemisphere...
  20. Building a Selective Inhibitory Control Tone in Autism: An rTMS Study
    Manuel F Casanova; Fiscal Year: 2012
    ..In brief, reports on independent populations have shown a reduction in the neuropil space at the periphery of the minicolumn...
  21. AGING AND ALZHEIMER DEMENTIA--ROLE OF FIBROUS PROTEINS
    Shu Hui Yen; Fiscal Year: 2000
    ..filaments (PHF), within neuronal perikarya and cell processes, in the form of neurofibrillary tangles (NFT), neuropil threads and dystrophic neurites in senile plaques...
  22. Translation at developing synapses
    Joseph Sebeo; Fiscal Year: 2010
    ..to be particularly prominent during development when the capacity for protein synthesis in dendritically enriched neuropil peaks;a general requirement for protein synthesis may thus operate locally...
  23. Optical imaging of the input and output of the olfactory bulb
    DOUGLAS STORACE; Fiscal Year: 2013
    ..with olfactory stimuli activating ensembles of receptor neurons that send axonal projections terminating in neuropil regions called glomeruli located on the surface of the olfactory bulb...
  24. Encoding and Modulation of Innately Relevant Odor Information in the Mouse
    Dara L Sosulski; Fiscal Year: 2010
    ..OB by the projections of first-order OSNs, which synapse on second-order mitral/tufted (M/T) cells in spheres of neuropil called glomeruli, but few have examined how odors with innate relevance are represented...
  25. SLASH: SCALABLE LARGE ANALYTIC SEGMENTATION HYBRID
    Tolga Tasdizen; Fiscal Year: 2013
    ..we propose to further develop and refine a prototype hybrid system for high-throughput segmentation of large neuropil datasets that: 1) advances automatic algorithms for segmentation of cellular and sub-cellular structures using ..
  26. PATHOLOGICAL ALTERATIONS IN ALZHEIMER'S DISEASE
    Bradley Hyman; Fiscal Year: 1993
    ..In addition, there is a recently-described accumulation of both amyloid protein and abnormal neurites in the neuropil. The goal of this application is to examine the anatomical relationships of these pathological changes to one ..
  27. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
    ..in vivo; (2) to examine the effects of TH on BDNF, NT-3 and RORalpha gene expression, and TH, BDNF and NT-3 on neuropil outgrowth and synaptogenesis in primary cultures of cerebellum of normal and sg mice in vitro; (3) to examine the ..
  28. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..how signaling via cholinergic pathways is related to foraging-induced increases in the volume of mushroom body neuropil using a novel experience-replacement technique;2...
  29. BRAIN FUNCTION
    J Robertson; Fiscal Year: 1992
    ..The trained animals will be taught a touch learning paradigm which requires that the particular neuropil studied be intact...
  30. REPERFUSION AND ISCHEMIC BRAIN NECROSIS
    KARL CONGER; Fiscal Year: 1993
    ..In the same sections, pericellular clear spaces and neuropil vacuolation will also be assessed as one index of tissue edema...
  31. Effects of VEGF on Brain Tissue in vitro
    JEFFREY ROSENSTEIN; Fiscal Year: 2004
    ..Experiments use a serum-free organotypic explant system to determine VEGF effects on neuropil at different perinatal developmental stages as well as primary culture assays of neurons, astroglia and isolated ..
  32. PET IMAGING PROBES FOR AMYLOID IN ALZHEIMERS AND AGING
    William Klunk; Fiscal Year: 2005
    ..and vascular amyloid and hyper-phosphorylated tau protein in neurofibrillary tangles, dystrophic neurites and neuropil threads...
  33. PET TRACERS TO MONITOR VACCINE AND IMMUNE THERAPY FOR AD
    William Klunk; Fiscal Year: 2005
    ..and vascular amyloid and hyper-phosphorylated tau protein in neurofibrillary tangles, dystrophic neurites and neuropil threads...
  34. Two-Photon Subpial Transections: Neocortical Epilepsy
    THEODORE SCHWARTZ; Fiscal Year: 2004
    ..These two-photon transections will be used to sever the neuropil, including somata and axonal and dendritic processes, to explore new possibilities for interrupting the ..
  35. NMDA EFFECTS ON DEVELOPING VISUAL SYNAPSES
    Martha Constantine Paton; Fiscal Year: 1992
    ..will attempt to use a new combined physiological and EM technique to identify the processes in the retinotectal neuropil with the highest concentrations of NMDA receptors by virtue of their ability to concentrate Ca++ ions...
  36. Array Tomographic Single-Synapse Analysis of Normal and Disordered Cortex
    Stephen Smith; Fiscal Year: 2009
    ..imaging to resolve and quantify individual synaptic puncta in three-dimensional volumes of cortical neuropil, and the use of high-order antibody multiplexing to discriminate amongst various molecularly defined synapse ..
  37. NERVE GROWTH FACTOR RECEPTOR MEDIATED TRANSPORT TOPICS
    John Schweitzer; Fiscal Year: 1991
    ..of the accumulation of NGF and IgG 192 in neurons, in terminal fields and potentially at the portal of entry into neuropil. Choline acetyltransferase (CAT) immunohistochemistry will be used to confirm the putative cholinergic nature of ..
  38. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
    ..It is hypothesized that a decrease in hippocampal neuropil, in response to diminished markers of neural growth and synaptic connection, resulting in an increase in neuronal ..
  39. MRSI of Frontosubcortical Circuits in Bipolar Disorder
    RAYMOND DEICKEN; Fiscal Year: 2004
    ..increased tissue volumes will be interpreted as evidence for possible increased neuronal number or interneuronal neuropil. Fourth, this proposal will determine if the magnitude and/or extent of regionally specific NAA alterations is ..
  40. Neural Development: Intercellular and Humoral Control
    Richard Levine; Fiscal Year: 2005
    ..of synapse formation in developing neural systems; the role of glial cells in the development of organized neuropil in the central nervous system; and molecular mechanisms of steroid hormone regulation of neuronal development...
  41. PROTEIN PRODUCTION DURING SPROUTING AND SYNAPTOGENESIS
    Linda Phillips; Fiscal Year: 1990
    The experiments of this proposal are designed to identify the proteins produced within the neuropil of the dentate gyrus during periods of neuronal sprouting and synapse growth...
  42. BRIAN SPECIFIC AMYLOID PLAQUE FORMATION
    Cho Yau Yeung; Fiscal Year: 1999
    ..and shown to develop cerebral amyloid deposits that are associated with ultrastructural abnormalities in the neuropil that include neuritic changes...
  43. IGF-1 in neocortical development and plasticity
    David Riddle; Fiscal Year: 2006
    ..unreadable] [unreadable] Moreover, the growth of neuropil in the cerebral cortex appears to be increased in transgenic mice in which IGF-1 is overexpressed and decreased ..
  44. Role of cAMP and HCN channels in stress-induced prefrontal dysfunction
    NAO JENNIFER GAMO; Fiscal Year: 2010
    ..Neuropathological studies have demonstrated loss of neuropil, including loss of dendritic spines, in the PFC of patients with schizophrenia, and imaging studies suggest that ..
  45. DISRUPTION OF ZINC HOMEOSTASIS IN ALZHEIMER'S DISEASE
    Mark Lovell; Fiscal Year: 2004
    ..of zinc's role in AD by a) quantitating levels of Zn in NFT-bearing, NFT-free and control neurons and neuropil in sections of flash-frozen AD and control brain and in neurons and neuropil from PS- 1 mutant and wildtype (WT) ..
  46. CORTICAL MECHANISMS IN SCHIZOPHRENIA
    Patricia Goldman Rakic; Fiscal Year: 2002
    ..by the hypothesis that neurotransmitter dysregulation may produce compromised cortical architecture ("reduced neuropil") and is a primary feature of cortical functional disturbance in particularly dopamine (DA), in the regulation of ..
  47. NEUROTROPHINS AND TRANSPLANTS IN SPINAL CORD INJURY
    BRADFORD STOKES; Fiscal Year: 2002
    Spinal cord injury results in the loss of neuropil at the injury site and disruption of ascending and descending fibers that pass through the lesioned area...
  48. OPTICAL STUDIES OF NEURON FUNCTION
    Katherine Graubard; Fiscal Year: 1990
    ..in different regions of identified cells? Methods to be used in this study include: intracellular somatic and neuropil recording, simultaneous measurements of internal calcium fluctuations in different regions of single neurons by ..
  49. ROLE OF NO SYNTHASE-2 IN MURINE ALZHEIMER'S DISEASE
    Carl Nathan; Fiscal Year: 2004
    ..in demonstrating the presence of NOS2 in brains of patients with AD, associated with tangle-bearing neurons and neuropil. The advent of mice bearing AD-associated transgenes and the PI's generation of mice with disrupted alleles for ..
  50. IMAGING BRAIN BLOOD VESSELS DURING CORTICAL ACTIVITY
    THOMAS WOOLSEY; Fiscal Year: 1999
    ..coupled endothelium to relax arteriolar smooth muscle and to change LCBF depending on the activity of the neuropil. The experiments are designed to examine this hypothesis directly...
  51. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2007
    ..It also revealed differences in their internal structure: less neuropil space in the periphery of the minicolumn and increased mean cell spacing...
  52. Neurobiology of a Simple Oculomotor System: Circuitry
    NICHOLAS STRAUSFELD; Fiscal Year: 2008
    ..It will also lead to the implementation of silicon-based circuits that enable motion detection and shape discrimination and potentially provide the basis for a visual prosthetic device. [unreadable] [unreadable]..
  53. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2005
    ..Our test revealed smaller values for all spacing distances and neuropil space in area 9 of schizophrenic brains...
  54. Conf Proposal:Gordon Research Conf on Neuroethology 2005
    NICHOLAS STRAUSFELD; Fiscal Year: 2005
    ..The conference is intended for the broad neuroethological community at all professional levels including advanced graduate and postdoctoral trainees. ..
  55. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2004
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  56. Gross morphological correlates to the minicolumnopathy of autism
    Manuel F Casanova; Fiscal Year: 2010
    ..e., minicolumnar narrowing most prominently in the peripheral neuropil space...
  57. Conference: Progress and Issues in Olfactory Development
    Lynne Oland; Fiscal Year: 2002
    ..Several delegates whose primary research areas lie in other sensory systems but whose interests lie in related developmental questions also will be invited. ..
  58. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  59. DROSOPHILA SENSORY NEURON DEVELOPMENT
    Volker Hartenstein; Fiscal Year: 2007
    ..abstract_text> ..
  60. Genetic Control of Intestinal Stem Cells in the Drosophila Hindgut
    Volker Hartenstein; Fiscal Year: 2010
    ..abstract_text> ..
  61. DROSOPHILA SENSORY NEURON DEVELOPMENT
    Volker Hartenstein; Fiscal Year: 2006
    ..We expect that the results of these proposed aims will apply to neural development widely (in particular to vertebrates) because the high degree of conservation between morphogenetic processes shaping animal brains. ..
  62. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  63. AMYLOIDOGENIC EFFECTS OF CHOLINERGIC DENERVATION
    Thomas Beach; Fiscal Year: 2002
    ..This could lead to impaired cerebral vasoregulation and increased susceptibility to ischemia, further compromising cortical function in AD. ..
  64. Neuropathology and Pathogenesis of Huntington's Disease
    Anton Reiner; Fiscal Year: 2008
    ..abstract_text> ..
  65. Bcl-2 Family Protein and Apoptosis in Schizophrenia
    LARS JARSKOG; Fiscal Year: 2005
    ..Stereological neuronal cell counting and measurement of somal size will also be assessed. Finally, young adult rats will receive typical and atypical antipsychotics to assess their effect on the apoptotic regulatory proteins. ..