neuropil

Summary

Summary: A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.

Top Publications

  1. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
  2. pmc The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging
    Iván J Cajigas
    Max Planck Institute for Brain Research, Max von Laue Strasse 3, Frankfurt am Main 60438, Germany
    Neuron 74:453-66. 2012
  3. doi The accessory olfactory bulb in the adult rat: a cytological study of its cell types, neuropil, neuronal modules, and interactions with the main olfactory system
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, CP 76001 Qro, Mexico
    J Comp Neurol 510:309-50. 2008
  4. doi Organization of deutocerebral neuropils and olfactory behavior in the centipede Scutigera coleoptrata (Linnaeus, 1758) (Myriapoda: Chilopoda)
    Andy Sombke
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll Straße 8, 07745 Jena, Germany
    Chem Senses 36:43-61. 2011
  5. doi Neuronal organization of the hemiellipsoid body of the land hermit crab, Coenobita clypeatus: correspondence with the mushroom body ground pattern
    Gabriella Wolff
    Department of Neuroscience, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 520:2824-46. 2012
  6. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
  7. ncbi Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Neurobiol 41:189-207. 1999
  8. doi Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*
    Alexander R Judkins
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Pathol 20:133-9. 2010
  9. doi Transition from marine to terrestrial ecologies: changes in olfactory and tritocerebral neuropils in land-living isopods
    S Harzsch
    Universitat Greifswald, Fachbereich Biologie, Abteilung Cytologie und Evolutionsbiologie, J S Bach Strasse 11 12, D 17498 Greifswald, Germany
    Arthropod Struct Dev 40:244-57. 2011
  10. pmc Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex
    Omer Ali Bayraktar
    Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Neural Dev 5:26. 2010

Research Grants

  1. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2010
  2. SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DIS
    Eliezer Masliah; Fiscal Year: 1993
  3. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
  4. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
  5. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2007
  6. Role of Astrocyte Injury in Neuroprotection
    Martin Philbert; Fiscal Year: 2010
  7. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
  8. PET IMAGING PROBES FOR AMYLOID IN ALZHEIMERS AND AGING
    William Klunk; Fiscal Year: 2005
  9. Dopaminergic Regulation of Pyramidal Cells
    Ariel Y Deutch; Fiscal Year: 2010
  10. Dopaminergic Regulation of Pyramidal Cells
    Ariel Y Deutch; Fiscal Year: 2011

Detail Information

Publications222 found, 100 shown here

  1. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
    ..generates different leg motoneuron subtypes, starting with those innervating proximal targets and medial neuropil regions and producing progeny that innervate distal muscle targets and lateral neuropil later in the lineage...
  2. pmc The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging
    Iván J Cajigas
    Max Planck Institute for Brain Research, Max von Laue Strasse 3, Frankfurt am Main 60438, Germany
    Neuron 74:453-66. 2012
    ..Here, we use deep sequencing to identify the mRNAs resident in the synaptic neuropil in the hippocampus...
  3. doi The accessory olfactory bulb in the adult rat: a cytological study of its cell types, neuropil, neuronal modules, and interactions with the main olfactory system
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, CP 76001 Qro, Mexico
    J Comp Neurol 510:309-50. 2008
    ..The second layer, or glomerular layer, is also divided by a conspicuous invagination of the neuropil of the ECL at the junction of the rostral and caudal halves...
  4. doi Organization of deutocerebral neuropils and olfactory behavior in the centipede Scutigera coleoptrata (Linnaeus, 1758) (Myriapoda: Chilopoda)
    Andy Sombke
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll Straße 8, 07745 Jena, Germany
    Chem Senses 36:43-61. 2011
    ..These results are in line with the morphological findings concerning the well-developed olfactory centers in the deutocerebrum of this species...
  5. doi Neuronal organization of the hemiellipsoid body of the land hermit crab, Coenobita clypeatus: correspondence with the mushroom body ground pattern
    Gabriella Wolff
    Department of Neuroscience, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 520:2824-46. 2012
    ..We conclude that crustaceans, insects, and other groups of arthropods share an ancestral neuronal ground pattern that is specific to their second-order olfactory centers...
  6. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
    ..detection of antibodies to cell surface or synaptic proteins demonstrated that six patients had antibodies to the neuropil of hippocampus or cerebellum, and one to intraneuronal antigens...
  7. ncbi Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Neurobiol 41:189-207. 1999
    The central complex is an important center for higher-order brain function in insects. It is an intricate neuropil composed of four substructures...
  8. doi Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*
    Alexander R Judkins
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Pathol 20:133-9. 2010
    ..feature and were present in 11/14 (79%) tumors, eight (73%) of which were embryonal tumors with abundant areas of neuropil-like differentiation...
  9. doi Transition from marine to terrestrial ecologies: changes in olfactory and tritocerebral neuropils in land-living isopods
    S Harzsch
    Universitat Greifswald, Fachbereich Biologie, Abteilung Cytologie und Evolutionsbiologie, J S Bach Strasse 11 12, D 17498 Greifswald, Germany
    Arthropod Struct Dev 40:244-57. 2011
    ..Evidence suggests that Isopoda have evolved, and are in the process of evolving, several novel solutions to chemical perception on land and in air...
  10. pmc Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex
    Omer Ali Bayraktar
    Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Neural Dev 5:26. 2010
    ..In addition, we use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory...
  11. ncbi Early development of the Drosophila brain: III. The pattern of neuropile founder tracts during the larval period
    Claude Nassif
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:417-34. 2003
    ..These models form part of our effort to generate an anatomic framework of Drosophila larval brain structure required for accurate localization of gene expression and gene function in experimental studies of neural development...
  12. ncbi Structure of the mushroom bodies of the insect brain
    Susan E Fahrbach
    Department of Biology, Wake Forest University, Winston Salem, North Carolina, 27109, USA
    Annu Rev Entomol 51:209-32. 2006
    ..Two topics are highlighted: the volume plasticity of mushroom body neuropils evident in the brains of some adult insects and a possible essential role for the gamma lobe in olfactory memory...
  13. ncbi Immunolocalisation of crustacean-SIFamide in the median brain and eyestalk neuropils of the marbled crayfish
    M A Polanska
    Institute of Infectious Diseases, Medical University of Warsaw, Warsaw, 02 106, Poland
    Cell Tissue Res 330:331-44. 2007
    ..Taken together, we suggest an important role of crustacean-SIFamidergic neurons in processing high-order, multimodal input in the crayfish brain...
  14. ncbi Ecological, evolutionary, and functional correlates of sensilla number and glomerular density in the olfactory system of decapod crustaceans
    Barbara S Beltz
    Department of Biological Sciences, Wellesley College, Wellesley, Massachusetts 02481, USA
    J Comp Neurol 455:260-9. 2003
    ..and invertebrate species is the division of the primary processing area into distinct clumps of synaptic neuropil, called glomeruli...
  15. pmc Brain organization and the origin of insects: an assessment
    Nicholas James Strausfeld
    Division of Neurobiology and The Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Biol Sci 276:1929-37. 2009
    ..Neural organization in brain centres, comprising olfactory pathways, optic lobes and a central neuropil that is thought to play a cardinal role in multi-joint movement, support affinities between insects and ..
  16. ncbi Neuronal intranuclear and neuropil inclusions for pathological assessment of Huntington's disease
    Marion Maat-Schieman
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Brain Pathol 17:31-7. 2007
    To evaluate the usefulness of neuronal intranuclear inclusions and neuropil inclusions for the pathological assessment of Huntington's disease (HD), their presence in neocortex was assessed by ubiquitin and N-terminal huntingtin ..
  17. doi Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes
    Sumihito Nobusawa
    Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Brain Pathol 22:689-97. 2012
    Recently, it was reported that ependymoblastoma and embryonal tumor with abundant neuropil and true rosettes (ETANTR) show 19q13.42 amplification at a high frequency, suggesting that these tumors may constitute a single entity...
  18. doi Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor
    Marco Gessi
    Division of Neuropathology, IRCCS Neurological Inst C Besta, Milan, Italy
    Am J Surg Pathol 33:211-7. 2009
    ..histologic features of ependymoblastoma and neuroblastoma, a lesion referred to as "embryonal tumor with abundant neuropil and true rosettes" (ETANTR)...
  19. ncbi Neuronal architecture of the mosquito deutocerebrum
    Rickard Ignell
    Division of Chemical Ecology, Department of Crop Science, Swedish University of Agricultural Sciences, SE 23053 Alnarp, Sweden
    J Comp Neurol 493:207-40. 2005
    ..Within the antennal nerve a specific neuropil containing early, bouton-like ramifications of receptor neurons is described...
  20. ncbi A novel octopamine receptor with preferential expression in Drosophila mushroom bodies
    K A Han
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 18:3650-8. 1998
    ..analysis using an antibody made to the receptor revealed highly enriched expression in the mushroom body neuropil and the ellipsoid body of central complex, brain areas known to be crucial for olfactory learning and motor ..
  21. ncbi Dual olfactory pathway in the honeybee, Apis mellifera
    Sebastian Kirschner
    Department of Behavioral Physiology and Sociobiology, Biozentrum, University of Wurzburg, Wurzburg, Germany
    J Comp Neurol 499:933-52. 2006
    ..The results indicate that olfactory input in the honeybee is processed via two separate, mainly uPN pathways to the MB calyx and LH and several pathways to the lateral protocerebrum...
  22. ncbi Comparative morphology of central neuropils in the brain of arthropods and its evolutionary and functional implications
    R Loesel
    Department of Developmental Biology and Morphology of Animals, Institute of Biology II, RWTH Aachen, Kopernikusstr 16, D 52056 Aachen, Germany
    Acta Biol Hung 55:39-51. 2004
    ..suggesting that central complexes in both groups are homologous structures derived from a basal ancestral neuropil. This ancestral archetype of the central complex (lacking the protocerebral bridge) might be represented in the ..
  23. doi Regulation of radial glial motility by visual experience
    Marc Tremblay
    McGill Graduate Program in Neuroscience, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:14066-76. 2009
    ..Structurally, radial glia extended and retracted many filopodial processes within the tectal neuropil over minutes...
  24. ncbi Embryonal tumor with abundant neuropil and true rosettes. A new entity or only variations of a parent neoplasms (PNETs)? This is the dilemma
    M La Spina
    Division of Hematology Oncology, Department of Pediatrics, Catania University Hospital, Catania, Sicily, Italy
    J Neurooncol 78:317-20. 2006
    ..at the pons and mesencephalon, has been histologically classified as an embryonal tumor containing abundant neuropil and true rosettes...
  25. pmc Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease
    Geoffrey A Kerchner
    Stanford Center for Memory Disorders, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroimage 63:194-202. 2012
    ..These findings highlight a role for 7T hippocampal microstructural imaging in revealing focal structural pathology that correlates with the central cognitive feature of AD...
  26. doi Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation
    Anna Maria Buccoliero
    Department of Biomedicine, Careggi Hospital, 50134 Florence, Italy
    Neuropathology 30:84-91. 2010
    ..Embryonal tumor with abundant neuropil and true rosettes is a recently recognized rare tumor...
  27. pmc Arborization pattern of engrailed-positive neural lineages reveal neuromere boundaries in the Drosophila brain neuropil
    Abhilasha Kumar
    Biozentrum, University of Basel, Basel, Switzerland
    J Comp Neurol 517:87-104. 2009
    ..complex structure composed of thousands of neurons that are interconnected in numerous exquisitely organized neuropil structures such as the mushroom bodies, central complex, antennal lobes, and other specialized neuropils...
  28. pmc Structural plasticity of circuits in cortical neuropil
    Gina Escobar
    Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA
    J Neurosci 28:8477-88. 2008
    ..New synaptic contacts appear in the neuropil where the gaps between axonal and dendritic branches can be bridged by dendritic spines...
  29. ncbi NADPH-diaphorase histochemical labeling patterns in the hippocampal neuropil and visual cortical neurons in weaned rats reared during lactation on different litter sizes
    Ana Paula Rocha-de-Melo
    Departamento de Nutricao, Universidade Federal de Pernambuco, BR 50670 901, Recife, PE, Brazil
    Nutr Neurosci 7:207-16. 2004
    ..We assessed morphometric features of the diaphorase-positive cells in visual cortex, and the neuropil histochemical activity in hippocampal CA1 and dentate gyrus using densitometry analysis...
  30. pmc Distribution of extracellular glutamate in the neuropil of hippocampus
    Melissa A Herman
    Vollum Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e26501. 2011
    ..We suggest that, in the CA1 region of hippocampus, glutamate transporters do not create a privileged space within the synapse but rather keep ambient glutamate at very low levels throughout the neuropil.
  31. pmc Comparative analysis of deutocerebral neuropils in Chilopoda (Myriapoda): implications for the evolution of the arthropod olfactory system and support for the Mandibulata concept
    Andy Sombke
    Ernst Moritz Arndt University of Greifswald, Zoological Institute and Museum, Cytology and Evolutionary Biology, 17487 Greifswald, Germany
    BMC Neurosci 13:1-17. 2012
    ....
  32. pmc Ultrastructural analysis of hippocampal neuropil from the connectomics perspective
    Yuriy Mishchenko
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
    Neuron 67:1009-20. 2010
    ..Thus, it will be difficult to predict synaptic connectivity using data sets missing ultrastructural details that distinguish between axo-dendritic touches and bona fide synapses...
  33. doi Embryonal tumors with abundant neuropil and true rosettes: 2 illustrative cases and a review of the literature
    Sunil Manjila
    Division of Pediatric Neurosurgery, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Neurosurg Focus 30:E2. 2011
    Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a recently identified variant of primitive neuroectodermal tumor, with fewer than 50 cases reported in the literature to date...
  34. pmc Asymmetric inhibition of Ulk2 causes left-right differences in habenular neuropil formation
    Robert W Taylor
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37205, USA
    J Neurosci 31:9869-78. 2011
    ..The habenular nuclei of zebrafish are robustly asymmetric, with dense elaboration of neuropil only in the left lateral subnucleus...
  35. pmc The clock input to the first optic neuropil of Drosophila melanogaster expressing neuronal circadian plasticity
    Milena Damulewicz
    Department of Cell Biology and Imaging, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 6:e21258. 2011
    In the first optic neuropil (lamina) of the fly's visual system, two interneurons, L1 and L2 monopolar cells, and epithelial glial cells show circadian rhythms in morphological plasticity...
  36. ncbi Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation
    Christopher Dunham
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box, 8118, St Louis, MO 63110, USA
    J Neurooncol 84:91-8. 2007
    ..one year later, and tissue from that resection proved to be diagnostic for an embryonal tumor with abundant neuropil and true rosettes (ETANTR)...
  37. pmc The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil
    Simon G Sprecher
    Institute of Developmental and Cell Biology, Department of Biology, University of Fribourg, Chemin du Musee 10, 1700, Fribourg, Switzerland
    Dev Biol 358:33-43. 2011
    ..The visual system of the fruit fly larva represents a simple visual system (larval optic neuropil, LON) that consists of 12 PRs falling into two classes: blue-senstive PRs expressing Rhodopsin 5 (Rh5) and green-..
  38. doi 3D segmentation of SBFSEM images of neuropil by a graphical model over supervoxel boundaries
    Bjoern Andres
    HCI, University of Heidelberg, Speyerer Str 6, D 69115 Heidelberg, Germany
    Med Image Anal 16:796-805. 2012
    The segmentation of large volume images of neuropil acquired by serial sectioning electron microscopy is an important step toward the 3D reconstruction of neural circuits...
  39. doi Embryonal tumor with abundant neuropil and true rosettes (ETANTR): a new distinctive variety of pediatric PNET: a case-based update
    Belen Ferri Niguez
    Service of Pathology, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, Spain
    Childs Nerv Syst 26:1003-8. 2010
    ..A distinctive subtype of PNET called "embryonal tumor with abundant neuropil and true rosettes" (ETANTR) was reported in 2000.
  40. doi Time course changes of the striatum neuropil after unilateral dopamine depletion and the usefulness of the contralateral striatum as a control structure
    MaríaRosa Avila-Costa
    Departamento de Neurociencias, Facultad de Estudios Superiores Iztacala, UNAM, Mexico City, Mexico
    Neurol Res 30:1068-74. 2008
    ..After unilateral dopamine depletion, some ipsilateral alterations occur and the contralateral structure has been utilized as control...
  41. ncbi Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropil
    T Kamiryo
    Department of Neurological Surgery, University of Virginia, Charlottesville 22908, USA
    Neurosurgery 49:409-14; discussion 414-5. 2001
    ..These results indicate that substantial changes in the neuropil do not occur 2 weeks before the time of definite necrosis formation, whereas changes in the basement membrane are ..
  42. ncbi Glomerular cytoarchitectures in chemosensory systems of arachnids
    P H Brownell
    Department of Zoology, Oregon State University, Corvallis 97331 2914, USA
    Ann N Y Acad Sci 855:502-7. 1998
    In most animals the central pathways of olfactory systems are associated with glomerular neuropil and lack topographic mapping of sensory inputs...
  43. doi Organization and postembryonic development of glial cells in the adult central brain of Drosophila
    Takeshi Awasaki
    Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts 01605, USA
    J Neurosci 28:13742-53. 2008
    ..It lays an essential foundation for studying glia development and function in the Drosophila brain...
  44. pmc Circadian control of dendrite morphology in the visual system of Drosophila melanogaster
    Paweł Weber
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    PLoS ONE 4:e4290. 2009
    In the first optic neuropil (lamina) of the fly's visual system, monopolar cells L1 and L2 and glia show circadian rhythms in morphological plasticity. They change their size and shape during the day and night...
  45. doi A systematic random sampling scheme optimized to detect the proportion of rare synapses in the neuropil
    Nuno Maçarico da Costa
    Institute for Neuroinformatics, University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Neurosci Methods 180:77-81. 2009
    ..When quantitative estimates are required for pathways that contribute a small proportion of synapses to the neuropil, the problems of accurate sampling are particularly severe and the total time required may become prohibitive...
  46. doi Evolution of the central complex in the arthropod brain with respect to the visual system
    Uwe Homberg
    Fachbereich Biologie, Tierphysiologie, Philipps Universitat Marburg, Karl von Frisch Strass8, D 35032 Marburg, Germany
    Arthropod Struct Dev 37:347-62. 2008
    ..In insects and crayfish, the central body is connected to a second midline-spanning neuropil, the protocerebral bridge. Both structures are collectively termed central complex...
  47. ncbi Octopamine-like immunoreactivity in the honey bee and cockroach: comparable organization in the brain and subesophageal ganglion
    Irina Sinakevitch
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 488:233-54. 2005
    ..The present observations are discussed with respect to possible roles of octopamine in sensory integration and association...
  48. ncbi Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice
    S J Tallaksen-Greene
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroscience 131:843-52. 2005
    We studied the development of neuronal intranuclear inclusions (NIIs), neuropil aggregates (NAs), and expression of expanded repeat polyglutamine protein in the HdhCAG(150) knockin mouse model of Huntington's disease (HD)...
  49. ncbi Organization of the honey bee mushroom body: representation of the calyx within the vertical and gamma lobes
    Nicholas J Strausfeld
    Division of Neurobiology, Arizona Research Laboratories, The University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 450:4-33. 2002
    ..The present findings suggest the need for critical reinterpretation of studies that have been predicated on early descriptions of the mushroom body's lobes...
  50. pmc An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction
    David E Featherstone
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Neurosci 25:3199-208. 2005
    ..GluRIID is expressed in the postsynaptic domain of the NMJ, as well as widely throughout the synaptic neuropil of the CNS...
  51. doi Development of nitrergic neurons in the nervous system of the locust embryo
    Michael Stern
    Cell Biology, Institute of Physiology, University of Veterinary Medicine Hannover, D 30173 Hannover, Germany
    J Comp Neurol 518:1157-75. 2010
    ..For the CNS, histochemical markers for NOS do not provide conclusive evidence for a developmental role of this enzyme...
  52. pmc Cyclical expression of Na+/K+-ATPase in the visual system of Drosophila melanogaster
    Jolanta Górska-Andrzejak
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow 30 060, Poland
    J Insect Physiol 55:459-68. 2009
    ..There, GFP expression occurs in medulla neuropil glia (MNGl), which express the clock gene per, and which closely contact the terminals of clock neurons ..
  53. ncbi Synaptic organization of the mushroom body calyx in Drosophila melanogaster
    Kouji Yasuyama
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 445:211-26. 2002
    The calyx neuropil of the mushroom body in adult Drosophila melanogaster contains three major neuronal elements: extrinsic projection neurons, presumed cholinergic, immunoreactive to choline acetyltransferase (ChAT-ir) and vesicular ..
  54. ncbi Spinal cord glioneuronal tumor with "rosetted" neuropil islands and meningeal dissemination: a case report
    B T Harris
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Acta Neuropathol 100:575-9. 2000
    Distinctive glioneuronal tumors arising within the cerebrum and displaying neuropil-like islands and tumor cells immunoreactive for neuronal and glial antigens have recently been described...
  55. doi Ordinary glomeruli in the antennal lobe of male and female tortricid moth Grapholita molesta (Busck) (Lepidoptera: Tortricidae) process sex pheromone and host-plant volatiles
    Nélia Varela
    Department of Crop Protection, Centre UdL IRTA, University of Lleida, Lleida, Spain
    J Exp Biol 214:637-45. 2011
    ..However, the absence of recorded pheromone responses in the Cu needs to be confirmed...
  56. ncbi Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications
    Marco Gessi
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy
    Acta Neuropathol 109:231-4. 2005
    We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting...
  57. pmc Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
    G A Kerchner
    Stanford Center for Memory Disorders, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Neurology 75:1381-7. 2010
    ..Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial ..
  58. doi Glioneuronal tumor with neuropil-like islands of the spinal cord with diffuse leptomeningeal neuraxis dissemination
    Bree Ruppert
    Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA
    J Neurooncol 104:529-33. 2011
    ..Histology revealed a WHO grade III glioneuronal tumor with rosetted neuropil-like islands...
  59. ncbi Innervation pattern of suboesophageal ventral unpaired median neurones in the honeybee brain
    Ulrike Schröter
    FB Biologie Chemie Pharmazie, Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Strasse 28 30, 14195 Berlin, Germany
    Cell Tissue Res 327:647-67. 2007
    ..In addition, we describe one labial unpaired median neurone with a dorsal cell body, DUMlb1. The possible homology between the honeybee VUM neurones and the unpaired median neurones in other insects is discussed...
  60. ncbi Early development of the Drosophila brain: IV. Larval neuropile compartments defined by glial septa
    Amelia Younossi-Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:435-50. 2003
    ..Neuropile compartments, representing easily identifiable landmark structures, will assist in future analyses of Drosophila brain development in which the exact location of neurons and their axonal trajectories is of importance...
  61. ncbi Early development of the Drosophila brain: V. Pattern of postembryonic neuronal lineages expressing DE-cadherin
    Karin Dumstrei
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 455:451-62. 2003
    ..The map of larval lineages and their axonal projection will be important for future studies on postembryonic neurogenesis in Drosophila. It also lays a groundwork for investigating the role of DE-cadherin in larval brain development...
  62. ncbi Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease
    C W Picanço-Diniz
    Universidade Federal do Para, Centro de Ciencias Biologicas, Departamento de Morfologia, Laboratório de Neuroanatomia Funcional, Belem, Brazil
    Neuropathol Appl Neurobiol 30:292-303. 2004
    ..and late stages after the initiation of the disease we assessed features of the NADPH-d positive cells and the neuropil histochemical activity in CA1 and dentate gyrus using densitometric analysis...
  63. ncbi Reelin-immunoreactive neurons, axons, and neuropil in the adult ferret brain: evidence for axonal secretion of reelin in long axonal pathways
    Veronica Martinez-Cerdeno
    Neurodevelopment Laboratory, Department of Morphology, Autonoma University School of Medicine, E 28029 Madrid, Spain
    J Comp Neurol 463:92-116. 2003
    ..may be under the influence of Reelin, we systematically mapped Reelin-immunoreactive neuronal somata, axons, and neuropil in the brain and brainstem of ferrets...
  64. ncbi Synaptic connections of cholinergic antennal lobe relay neurons innervating the lateral horn neuropile in the brain of Drosophila melanogaster
    Kouji Yasuyama
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 466:299-315. 2003
    ..The significance of the postsynaptic neurites of the ChAT PNs is discussed; either local or other interneurons might connect the ChAT PNs within the LH, or PNs might receive inputs arising from outside the LH...
  65. ncbi Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity
    Kirsten Hoffmann
    Department of Neurobiology, Institute of Zoology, Berliner Strasse 28, Gottingen, Germany
    Zoolog Sci 24:1028-35. 2007
    ..In addition, basal muscarinic excitation in the central body neuropil seems to determine the general motivation of a grasshopper to stridulate...
  66. ncbi Expansion of the neuropil of the mushroom bodies in male honey bees is coincident with initiation of flight
    S E Fahrbach
    Department of Entomology, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Neurosci Lett 236:135-8. 1997
    ..There was an expansion of the neuropil of the MB that was temporally associated with drone behavioral development, as in female queens and workers...
  67. ncbi Embryonic origin of the Drosophila brain neuropile
    Amelia Younossi-Hartenstein
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 497:981-98. 2006
    ..This suggests that spatial information residing within neurons, rather than glial cells, specifies the location and initial shape of neuropile compartments...
  68. ncbi Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage
    Wayne Pereanu
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:5534-53. 2006
    ..Third, the atlas can serve as a repository for genes expressed in lineage-specific patterns...
  69. pmc Arthropod phylogeny: onychophoran brain organization suggests an archaic relationship with a chelicerate stem lineage
    Nicholas J Strausfeld
    Division of Neurobiology and The Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Proc Biol Sci 273:1857-66. 2006
    ..Neuroanatomical evidence suggests that the organization of the onychophoran brain is similar to that of the brains of chelicerates...
  70. ncbi Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites
    Matthias Landgraf
    Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
    Dev Biol 260:207-25. 2003
    ..Using the Fasciclin2-based mapping procedure as a standard (e.g., in a common database) would facilitate studies on the functional architecture of the neuropile and the identification of candiate circuit elements...
  71. ncbi Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    Liliana B Menalled
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 465:11-26. 2003
    ..These consisted of nuclear staining for huntingtin and huntingtin-containing nuclear and neuropil aggregates that first appeared in the striatum, nucleus accumbens, and olfactory tubercle...
  72. pmc Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia
    R O Kuljis
    Department of Neurology, University of Miami, Miami, FL 33136 2115, USA
    Proc Natl Acad Sci U S A 94:12688-93. 1997
    ..cerebellar cortex of 2-month-old Atm knockout mice, which is accompanied by glial activation, deterioration of neuropil structure, and both pre- and postsynaptic degeneration...
  73. ncbi Histological and cytological study of the bed nuclei of the stria terminalis in adult rat. II. Oval nucleus: extrinsic inputs, cell types, neuropil, and neuronal modules
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, UNAM, Juriquilla, Zona Centro Querétaro, CP 76001 Querétaro, Mexico
    J Comp Neurol 497:772-807. 2006
    ..capsule, ventral amygdaloid pathway, and medial forebrain bundle are the main sources of afferents to the neuropil of the Ov...
  74. ncbi Stereotyped neuropil branching of an identified stomatogastric motor neuron
    Ann E Wilensky
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    J Comp Neurol 466:554-63. 2003
    Anatomical studies of the crab stomatogastric ganglion (STG) have suggested only minimal organization within the neuropil of this structure...
  75. ncbi Conserved and convergent organization in the optic lobes of insects and isopods, with reference to other crustacean taxa
    I Sinakevitch
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    J Comp Neurol 467:150-72. 2003
    ..However, in certain insects, the lobula is accompanied by a tectum-like fourth neuropil, the lobula plate, characterized by wide-field tangential neurons and linked to the medulla by uncrossed axons...
  76. ncbi Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice
    H Li
    Department of Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 21:8473-81. 2001
    ..Here we report that in mice expressing full-length mutant huntingtin and modeling early stages of HD, neuropil aggregates form preferentially in the LGP and SN...
  77. ncbi Neurobiology of the basal platyhelminth Macrostomum lignano: map and digital 3D model of the juvenile brain neuropile
    Joshua Morris
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Genes Evol 217:569-84. 2007
    ..This study will aid in the documentation and interpretation of patterns of gene expression, as well as functional studies, in the developing Macrostomum brain...
  78. pmc Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis
    Marta Zlatic
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000135. 2009
    ..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension...
  79. ncbi Synapse loss from chronically elevated glucocorticoids: relationship to neuropil volume and cell number in hippocampal area CA3
    Despina A Tata
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, New York 11790 2500, USA
    J Comp Neurol 498:363-74. 2006
    ..a comprehensive study of glucocorticoid effects on hippocampal CA3 volume and identified elements in the neuropil including astrocytic volume and cell and synapse number and size...
  80. pmc Hardwiring of fine synaptic layers in the zebrafish visual pathway
    Linda M Nevin
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Neural Dev 3:36. 2008
    ..Here we investigated two stratified areas of the zebrafish visual pathway, the inner plexiform layer (IPL) of the retina and the neuropil of the optic tectum, and determined if activity is required for their organization.
  81. ncbi F-actin at identified synapses in the mushroom body neuropil of the insect brain
    Ina Frambach
    Institut fur Zoologie, Anthropologie und Entwicklungsbiologie, University of Gottingen, 37073 Gottingen, Germany
    J Comp Neurol 475:303-14. 2004
    ..The accumulation of f-actin in KC dendrites is discussed in view of mushroom body plasticity and its potential role in learning and memory formation...
  82. ncbi Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster
    Verónica G Rodriguez Moncalvo
    Department of Biology, McMaster University, 1280 Main St West, Hamilton, ON, Canada
    Dev Biol 286:549-58. 2005
    ..These neurons send their axons in a fascicle, the larval optic nerve (LON), which terminates in the larval optic neuropil. The LON is required for the development of a serotonergic arborization originating in the central brain and for ..
  83. ncbi Compartmentalization of central neurons in Drosophila: a new strategy of mosaic analysis reveals localization of presynaptic sites to specific segments of neurites
    Robert Lohr
    Institute of Genetics, University of Mainz, D 55128 Mainz, Germany
    J Neurosci 22:10357-67. 2002
    ..This suggests that synaptogenic mechanisms in the CNS might differ from those at neuromuscular junctions...
  84. pmc Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
    Chuan En Wang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 181:803-16. 2008
    ..However, the contribution of cytoplasmic mutant huntingtin and its aggregates in neuronal processes (neuropil aggregates) has not been rigorously explored...
  85. doi Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-Immunoreactive neuropil
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland
    J Affect Disord 113:45-55. 2009
    ..Alterations of GABAergic neurotransmission are assumed to play a crucial role in the pathophysiology of mood disorders. Glutamic acid decarboxylase (GAD) is the key enzyme of GABA synthesis...
  86. ncbi Comparison of octopamine-like immunoreactivity in the brains of the fruit fly and blow fly
    Irina Sinakevitch
    Arizona Research Laboratories Division of Neurobiology, University of Arizona, Tucson, Arizona 85719, USA
    J Comp Neurol 494:460-75. 2006
    ..The results are also discussed with respect to recent studies on octopamine-immunoreactive organization in honey bees and cockroaches and the suggested roles of octopamine in sensory processing, learning, and memory...
  87. ncbi Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes
    Federica Piccioni
    Institute of Endocrinology, Centre of Excellence for the Study and Treatment of Neurodegenerative Diseases, University of Milan, Milano, Italy
    FASEB J 16:1418-20. 2002
    ..Nuclear, cytoplasmic, or neuropil aggregates are detectable in CAG/polyGln-related diseases, but their role is still debated...
  88. ncbi Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain
    Thomas Rival
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, F 13288 Marseille Cedex 9, France
    Curr Biol 14:599-605. 2004
    ..glutamate transporter, dEAAT1, is selectively addressed to glial extensions that project ubiquitously through the neuropil close to synaptic areas...
  89. ncbi Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregaria
    Angela E Kurylas
    Fachbereich Biologie, Tierphysiologie, , D 35032 Marburg, Germany
    J Comp Neurol 484:206-23. 2005
    ..About 470 neuronal cell bodies in the locust midbrain were NADPHd-positive positive, and nearly all major neuropil centers contained dense, sharply stained arborizations...
  90. ncbi Glioneuronal tumor with neuropil-like islands (GTNI): a report of 8 cases with chromosome 1p/19q deletion analysis
    Violetta Barbashina
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 31:1196-202. 2007
    Glioneuronal tumor with neuropil-like islands (GTNI) is a rare neoplasm harboring circumscribed loci of neuronal differentiation and diffusely infiltrating astroglial and oligodendrocytelike components...
  91. ncbi N-methyl-D-aspartate receptor-like immunoreactivity in the brain of Sepia and Octopus
    Anna Di Cosmo
    Department of Biological and Environmental Sciences, University of Sannio, 82100 Benevento, Italy
    J Comp Neurol 477:202-19. 2004
    ..These findings suggest that glutamate, via NMDA receptors, may be involved as a signaling molecule in motor, learning, visual, and olfactory systems in the cephalopod brain...
  92. ncbi Microanatomy of the dysplastic neocortex from epileptic patients
    L Alonso-Nanclares
    Instituto Cajal, CSIC, Madrid, Spain
    Brain 128:158-73. 2005
    ..We discuss the possible relationship between these alterations and epilepsy, bearing in mind the possible limitations that preclude the extrapolation of the results to the whole population of epileptic patients with dysplastic neocortex...
  93. ncbi Cerebral expression of the alpha2-subunit of soluble guanylyl cyclase is linked to cerebral maturation and sensory pathway refinement during postnatal development
    Hans J Bidmon
    C and O Vogt Institute of Brain Research, Heinrich Heine University, University Street 1, D 40225 Dusseldorf, Germany
    Neurochem Int 45:821-32. 2004
    ..In addition the alpha2-subunit may serve other functions than forming a functional heterodimer of sGC during the early phases of sensory pathway refinement...
  94. ncbi Distribution of a brain-specific extracellular matrix protein in developing and adult zebrafish
    Takahiro Kanai
    Department of Biology, Faculty of Science, Okayama University, Okayama 700 0082, Japan
    Brain Res 1129:53-62. 2007
    ..These patterns of distribution are very different from those of other typical brain ECM proteins and suggest that this protein may play quite distinct roles in brain development and maintenance...
  95. ncbi Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
    Luc Pellerin
    Department of Physiology, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland
    J Neurosci Res 79:55-64. 2005
    ....
  96. ncbi Three-dimensional average-shape atlas of the honeybee brain and its applications
    Robert Brandt
    Institut für Biologie Neurobiologie, Freie Universitat Berlin, D 14195 Berlin, Germany
    J Comp Neurol 492:1-19. 2005
    ..lobe, the axon terminals of two identified m-ACT neurons arborize in separate but close areas of the neuropil; and 3) that MB-intrinsic clawed Kenyon cells (type 5), with somata outside the calycal cups, project to the ..
  97. ncbi Transient ischemia-induced changes of neurofilament 200 kDa immunoreactivity and protein content in the main olfactory bulb in gerbils
    In Koo Hwang
    Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    J Neurol Sci 239:59-66. 2005
    ....
  98. ncbi Localization of connexins in neurons and glia cells of the Helix aspersa suboesophageal brain ganglia by immunocytochemistry
    M J Azanza
    Laboratorio de Magnetobiología, Departamento de Anatomia e Histologia Humanas, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
    Histol Histopathol 22:497-504. 2007
    ..of the ganglia while the small immunostained cells (5-25 microm diameter) were observed in groups near the neuropil. The number of large neurons giving positive Cx26-like immunostaining was small in comparison with that for ..
  99. ncbi FMRFamide-like immunocytochemistry in the brain and subesophageal ganglion of Triatoma infestans (Insecta: Heteroptera). Coexpression with beta-pigment-dispersing hormone and small cardioactive peptide B
    Beatriz P Settembrini
    Facultad de Ciencias Biomedicas, Universidad Austral, Pilar, Pcia de Buenos Aires, Argentina
    Cell Tissue Res 321:299-310. 2005
    ..Immunostained neurites were detected in the medulla and lobula of the optic lobe, the lateral protocerebral neuropil, the median bundle, the calyces and the stalk of the mushroom bodies, and the central body...
  100. ncbi Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons
    John P McGann
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Neuron 48:1039-53. 2005
    ..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity...
  101. ncbi [Localization of NADPH-diaphorase in the brain of the shore crab Hemigrapsus sanguineus]
    E P Kotsiuba
    Tsitologiia 47:237-42. 2005
    ..of this enzyme was found in the deutrocerebrum, mainly in neuropils of olfactory lobes, the lateral antennular neuropil, a laterodorsal group of cells, and in the oculomotor nerve nucleus...

Research Grants75

  1. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2010
    ..changes in cortical GM FA reflect changes in the distribution of axonal and dendritic neuronal processes in the neuropil. This hypothesis stems from an analytical model that we recently developed to relate diffusion anisotropy in the ..
  2. SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DIS
    Eliezer Masliah; Fiscal Year: 1993
    ..We hypothesize that in those areas the dystrophic neurites scattered in the neuropil and in the plaques originate in the abnormal axons and presynaptic terminals, as the result of the aberrant ..
  3. THYROID HORMONE ACTION IN NEUROGENESIS
    Richard Maas; Fiscal Year: 2001
    ..in vivo; (2) to examine the effects of TH on BDNF, NT-3 and RORalpha gene expression, and TH, BDNF and NT-3 on neuropil outgrowth and synaptogenesis in primary cultures of cerebellum of normal and sg mice in vitro; (3) to examine the ..
  4. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
    ..It is hypothesized that a decrease in hippocampal neuropil, in response to diminished markers of neural growth and synaptic connection, resulting in an increase in neuronal ..
  5. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2007
    ..how signaling via cholinergic pathways is related to foraging-induced increases in the volume of mushroom body neuropil using a novel experience-replacement technique; 2...
  6. Role of Astrocyte Injury in Neuroprotection
    Martin Philbert; Fiscal Year: 2010
    Astrocytes are an important component of the neuropil and their dysfunction has been associated with a variety of idiopathic and genetic diseases including Alzheimer's and Parkinson's disease and in energy deprivation ..
  7. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..how signaling via cholinergic pathways is related to foraging-induced increases in the volume of mushroom body neuropil using a novel experience-replacement technique; 2...
  8. PET IMAGING PROBES FOR AMYLOID IN ALZHEIMERS AND AGING
    William Klunk; Fiscal Year: 2005
    ..and vascular amyloid and hyper-phosphorylated tau protein in neurofibrillary tangles, dystrophic neurites and neuropil threads...
  9. Dopaminergic Regulation of Pyramidal Cells
    Ariel Y Deutch; Fiscal Year: 2010
    ..schizophrenia have noted a decrease in PFC volume that is not due to a loss of neurons, but rather a decrease in neuropil, suggesting changes in the size of cell bodies, a decrease in presynaptic elements, or a pruning of the dendritic ..
  10. Dopaminergic Regulation of Pyramidal Cells
    Ariel Y Deutch; Fiscal Year: 2011
    ..schizophrenia have noted a decrease in PFC volume that is not due to a loss of neurons, but rather a decrease in neuropil, suggesting changes in the size of cell bodies, a decrease in presynaptic elements, or a pruning of the dendritic ..
  11. Effects of VEGF on Brain Tissue in vitro
    JEFFREY ROSENSTEIN; Fiscal Year: 2004
    ..Experiments use a serum-free organotypic explant system to determine VEGF effects on neuropil at different perinatal developmental stages as well as primary culture assays of neurons, astroglia and isolated ..
  12. PET TRACERS TO MONITOR VACCINE AND IMMUNE THERAPY FOR AD
    William Klunk; Fiscal Year: 2005
    ..and vascular amyloid and hyper-phosphorylated tau protein in neurofibrillary tangles, dystrophic neurites and neuropil threads...
  13. BIOLOGY OF ALZHEIMER PAIRED HELICAL FILAMENTS
    Virginia Lee; Fiscal Year: 1993
    ..disease (AD) is characterized by the accumulation of neurofibrillary tangles (NFTs), senile plaques (SPs) and neuropil threads (NTs) in selected telencephalic regions that are especially vulnerable to degeneration...