visceral afferents

Summary

Summary: The sensory fibers innervating the viscera.

Top Publications

  1. ncbi Colorectal distension-induced suppression of a nociceptive somatic reflex response in the rat: modulation by tissue injury or inflammation
    Jaakko Kalmari
    Biomedicum Helsinki, Institute of Biomedicine Physiology, University of Helsinki, 00014, Finland
    Brain Res 1018:106-10. 2004
  2. pmc Gut chemosensing: interactions between gut endocrine cells and visceral afferents
    Helen E Raybould
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Vet Med APC, 1320 Haring Hall, 1, Shields Ave, Davis, CA 95616, USA
    Auton Neurosci 153:41-6. 2010
  3. ncbi The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 25:433-69. 2002
  4. ncbi Functional and chemical anatomy of the afferent vagal system
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Auton Neurosci 85:1-17. 2000
  5. ncbi Understanding the signaling and transmission of visceral nociceptive events
    Fernando Cervero
    Anaesthesia Research Unit, McGill University, McIntyre Medical Bldg, Room 1207, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Neurobiol 61:45-54. 2004
  6. pmc Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome
    M Delvaux
    Gastroenterology Unit, CHU Rangueil, Toulouse, France
    Gut 51:i67-71. 2002
  7. ncbi Unmyelinated visceral afferents exhibit frequency dependent action potential broadening while myelinated visceral afferents do not
    Bai Yan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Neurosci Lett 421:62-6. 2007
  8. ncbi Chemical stimulation of visceral afferents activates medullary neurones projecting to the central amygdala and periaqueductal grey
    Odile Viltart
    Laboratoire Stress Perinatal, JE2365, Universite de Lille I, 59655 Villeneuve d Ascq, France
    Brain Res Bull 71:51-9. 2006
  9. ncbi Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides
    Robert E Steinert
    Clinical Research Center, Department of Biomedicine and Division of Gastroenterology, University Hospital Basel, Basel, Switzerland
    Physiol Behav 105:62-70. 2011
  10. ncbi How do you feel? Interoception: the sense of the physiological condition of the body
    A D Craig
    Nat Rev Neurosci 3:655-66. 2002

Detail Information

Publications217 found, 100 shown here

  1. ncbi Colorectal distension-induced suppression of a nociceptive somatic reflex response in the rat: modulation by tissue injury or inflammation
    Jaakko Kalmari
    Biomedicum Helsinki, Institute of Biomedicine Physiology, University of Helsinki, 00014, Finland
    Brain Res 1018:106-10. 2004
    ....
  2. pmc Gut chemosensing: interactions between gut endocrine cells and visceral afferents
    Helen E Raybould
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Vet Med APC, 1320 Haring Hall, 1, Shields Ave, Davis, CA 95616, USA
    Auton Neurosci 153:41-6. 2010
    ....
  3. ncbi The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 25:433-69. 2002
    ..These pattern generators are located at multiple levels of the central nervous system, and they can be combined in temporal and spatial patterns to subserve a wide range of behavioral needs...
  4. ncbi Functional and chemical anatomy of the afferent vagal system
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Auton Neurosci 85:1-17. 2000
    ..Furthermore, these functions are in line with a general defensive character ascribed to the vagal afferent, paraventricular system in lower vertebrates...
  5. ncbi Understanding the signaling and transmission of visceral nociceptive events
    Fernando Cervero
    Anaesthesia Research Unit, McGill University, McIntyre Medical Bldg, Room 1207, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Neurobiol 61:45-54. 2004
    ..This article reviews current evidence on the mechanisms of activation and sensitization of visceral nociceptive afferents and on their role in the triggering and maintenance of clinically relevant visceral pain states...
  6. pmc Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome
    M Delvaux
    Gastroenterology Unit, CHU Rangueil, Toulouse, France
    Gut 51:i67-71. 2002
    ..The advances made in understanding visceral hypersensitivity in patients with IBS are reviewed: the factors that influence abdominal distension are defined and different therapeutic perspectives are examined...
  7. ncbi Unmyelinated visceral afferents exhibit frequency dependent action potential broadening while myelinated visceral afferents do not
    Bai Yan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Neurosci Lett 421:62-6. 2007
    ..g. increased neurotransmitter release.) We conclude that our observations are indicative of fundamentally different mechanisms for neural integration of sensory information arising from unmyelinated and myelinated vagal afferents...
  8. ncbi Chemical stimulation of visceral afferents activates medullary neurones projecting to the central amygdala and periaqueductal grey
    Odile Viltart
    Laboratoire Stress Perinatal, JE2365, Universite de Lille I, 59655 Villeneuve d Ascq, France
    Brain Res Bull 71:51-9. 2006
    ..NTS and VLM neurones may convey visceral afferent information to the CeA and the PAG...
  9. ncbi Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides
    Robert E Steinert
    Clinical Research Center, Department of Biomedicine and Division of Gastroenterology, University Hospital Basel, Basel, Switzerland
    Physiol Behav 105:62-70. 2011
    ....
  10. ncbi How do you feel? Interoception: the sense of the physiological condition of the body
    A D Craig
    Nat Rev Neurosci 3:655-66. 2002
    ..This system constitutes a representation of 'the material me', and might provide a foundation for subjective feelings, emotion and self-awareness...
  11. ncbi Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, and CRBA, University of Bologna, St Orsola Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 132:26-37. 2007
    ..However, the underlying mechanisms remain unknown. We assessed the effect of mast cell mediators released from the colonic mucosa of IBS patients on the activation of rat sensory neurons in vitro...
  12. ncbi Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns
    Timothy W Bailey
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 26:11893-902. 2006
    Cranial visceral afferents activate central pathways that mediate systemic homeostatic processes...
  13. ncbi Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. III. Visceral afferent pathways: a source of new therapeutic targets for abdominal pain
    L Bueno
    Institut National de la Recherche Agronomique, Neuro Gastroenterology and Nutrition Unit, 31931 Toulouse, France
    Am J Physiol Gastrointest Liver Physiol 278:G670-6. 2000
    ..This themes article addresses both physiological and preclinical issues of interest for the selection of active new drugs in regard to the clinical pharmacology of visceral pain...
  14. ncbi Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3578-85. 2005
    The nucleus tractus solitarius (NTS) receives dense terminations from cranial visceral afferents, including those from the gastrointestinal (GI) system...
  15. ncbi Pattern differentiation of excitatory and inhibitory synaptic inputs on distinct neuronal types in the rat caudal nucleus of the tractus solitarius
    Masayuki Yoshioka
    Department of Anatomy I, Jikei University School of Medicine, 3 25 8 Nishi Shimbashi Minato ku, Tokyo 105 8461, Japan
    Neurosci Res 55:300-15. 2006
    ..These results indicate that differential synaptic input patterns were developmentally established in distinct small and large neurons...
  16. ncbi Local axonal arborization patterns of distinct neuronal types in the caudal nucleus of the tractus solitarius
    Tomoaki Okada
    Department of Anatomy I, Jikei University School of Medicine, 3 25 8 Nishi Shimbashi Minato ku, Tokyo 105 8461, Japan
    Brain Res 1083:134-44. 2006
    ..It was suggested that small cNTS neurons contribute specifically to an integration of input information generated in the local circuits, while large neurons convey the integrated information to other autonomic brain regions...
  17. pmc Visceral perception: sensory transduction in visceral afferents and nutrients
    H E Raybould
    UC Davis School of Veterinary Medicine, CA 95616, USA
    Gut 51:i11-4. 2002
    ..This review focuses on the extrinsic afferent pathways as these are the ones that convey information to the central nervous system which is clearly necessary for perception to occur...
  18. ncbi Peripheral relays in stress-induced activation of visceral afferents in the gut
    Rene M van den Wijngaard
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Auton Neurosci 153:99-105. 2010
    ..organs are targeted by the stress response, but the focus of this article is on stress-induced activation of visceral afferents in the gut. During recent years it became apparent that mast cells are pivotal in this response...
  19. ncbi Vagal motor neurons in rats respond to noxious and physiological gastrointestinal distention differentially
    Xueguo Zhang
    Laboratory of Neurogastroenterology Research, Division of Gastroenterology, Henry Ford Health System, One Ford Place 2D, 6071 Second Avenue, Detroit, MI 48202, USA
    Eur J Neurosci 16:2027-38. 2002
    ..These results suggest that different reflexes are present between physiological distention and noxious stimulation of gastrointestinal tract...
  20. pmc Development, plasticity and modulation of visceral afferents
    Julie A Christianson
    University of Pittsburgh School of Medicine, Pittsburgh Center for Pain Research, 200 Lothrop St, Pittsburgh, PA 16261, USA
    Brain Res Rev 60:171-86. 2009
    ..b>Visceral afferents also play a central role in tissue homeostasis...
  21. ncbi Acute effects of capsaicin on gastrointestinal vagal afferents
    L A Blackshaw
    Nerve Gut Research Laboratory, Department of Gastrointestinal Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, Australia
    Neuroscience 96:407-16. 2000
    ..Acute desensitization may be induced with or without a response...
  22. pmc Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus
    James H Peters
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 28:11731-40. 2008
    Cranial visceral afferents travel via the solitary tract (ST) to contact neurons within the ST nucleus (NTS) and activate homeostatic reflexes...
  23. ncbi Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius
    Mark W Doyle
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    J Neurosci 22:8222-9. 2002
    Although the central terminals of cranial visceral afferents express vanilloid receptor 1 (VR1), little is known about their functional properties at this first synapse within the nucleus tractus solitarius (NTS)...
  24. pmc How many kinds of visceral afferents?
    M Costa
    Department of Physiology and Centre of Neuroscience, School of Medicine, Flinders University, Adelaide, Australia
    Gut 53:ii1-4. 2004
    ..This review deals with the morphological nature of the afferent neurones that supply the gastrointestinal tract specifically...
  25. pmc What activates visceral afferents?
    D Grundy
    Department of Biomedical Science, University of Sheffield, Western Bank, UK
    Gut 53:ii5-8. 2004
    ..Understanding the mechanisms that underlie hypersensitivity may have implications for the pharmaceutical approach to the treatment of functional bowel disorders like irritable bowel syndrome...
  26. ncbi Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons
    Jichang Li
    Division of Digestive Diseases, Department of Medicine, Center for Neurovisceral Sciences CNS and Women s Health, University of California, Warren Hall, Room 14 103, 900 Veterans Avenue, Los Angeles, CA 90095, USA
    Pain 109:443-52. 2004
    ..These results demonstrate that functional NMDARs expressed by DRG neurons innervating both somatic and visceral tissues of adult rats are composed predominantly of NR2B subunits...
  27. ncbi Brain stem convergence of pelvic viscerosomatic inputs via spinal and vagal afferents
    Charles H Hubscher
    Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40292, USA
    Neuroreport 15:1299-302. 2004
    ..The functional significance of this viscerosomatic convergence to MRF is unknown, but could relate to sensory/autonomic integration for coordinating multiple bodily functions, including reproductive and eliminative events...
  28. ncbi Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the rat
    T Tanimoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Exp Brain Res 145:468-79. 2002
    ..These results suggest that VA stimulation inhibits nociceptive transmission in the C1 spinal neuron activity via the activation of both noradrenergic and serotonergic (5-HT(3)) descending inhibitory systems...
  29. ncbi Vanilloid receptor VR1-positive afferents are distributed differently at different levels of the rat lumbar spinal cord
    S J Hwang
    Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul, 133 791, South Korea
    Neurosci Lett 349:41-4. 2003
    ..the neuropeptide substance P (SP) in lamina I and along the lateral collateral path, where the majority of visceral afferents terminate, is negligible at L4, but substantial at L6...
  30. ncbi Upregulation of corticotropin-releasing hormone gene expression in the paraventricular nucleus of cyclophosphamide-induced cystitis in male rats
    Kaori Mineta
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahakanishi, Kitakyushu 807 8555, Japan
    Brain Res 1018:193-200. 2004
    ....
  31. ncbi The influence of ovariectomy with or without estrogen replacement on responses of rat gracile nucleus neurons to stimulation of hindquarter skin and pelvic viscera
    Heather B Bradshaw
    Program in Neuroscience, Florida State University, Copeland Street, Tallahassee, FL 32306 1270, USA
    Brain Res 986:82-90. 2003
    ..The findings further suggest that NG is a component of neural systems that contribute to both reproductive behaviors and vaginal nociception...
  32. ncbi Convergent responses of Barrington's nucleus neurons to pelvic visceral stimuli in the rat: a juxtacellular labelling study
    Marie Laure Rouzade-Dominguez
    The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, 402 Abramson Pediatric Research Center, Philadelphia, PA 19104, USA
    Eur J Neurosci 18:3325-34. 2003
    ..Dysfunctions in this circuit may underlie the coexistence of colon and bladder symptoms observed in functional bowel disorders...
  33. ncbi Nociceptive visceral stimulation modulates the activity of cerebellar Purkinje cells
    C Y Saab
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1069, USA
    Exp Brain Res 140:122-6. 2001
    ..Based on these and previous findings, we propose a negative feedback circuitry involving the cerebellum for the modulation of peripheral nociceptive events...
  34. pmc Acupuncture inhibition on neuronal activity of spinal dorsal horn induced by noxious colorectal distention in rat
    Pei jing Rong
    Institute of Acupuncture, China Academy of Chinese Medicine, 16 Nanxiaojie of Dongzhimen, Beijing 100700, China
    World J Gastroenterol 11:1011-7. 2005
    ..These will provide scientific base for illustrating the mechanism of acupuncture on visceral pain...
  35. ncbi Neuropathy reduces viscero-somatic inhibition via segmental mechanisms in rats
    Antti Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku
    Neuroreport 13:1047-50. 2002
    ..The decreased inhibition of somatic signals may contribute to the hypersensitivity observed in neuropathic conditions...
  36. ncbi Role of tachykinin NK1, NK2 and NK3 receptors in the modulation of visceral hypersensitivity in the rat
    Geneviève Anne Gaudreau
    Neurobiology and Digestive Motility Laboratory, CHUM Research Centre, University of Montreal, Montreal, Quebec, Canada
    Neurosci Lett 351:59-62. 2003
    ....
  37. ncbi Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia
    Marion Danzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Eur J Neurosci 19:85-92. 2004
    ....
  38. ncbi Identification of dorsal root ganglion neurons that innervate the common bile duct of rats
    H Truong
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, Minneapolis, MN 55455, USA
    Exp Brain Res 155:477-84. 2004
    ..These results indicate that a large number of primarily small DRG cells, located bilaterally at many segmental levels, provide a rich innervation of the common bile duct...
  39. ncbi Cardiopulmonary sympathetic and vagal afferents excite C1-C2 propriospinal cells in rats
    Jianhua Zhang
    Department of Physiology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Brain Res 969:53-8. 2003
    ..Results are consistent with the hypothesis that CPSA input can be processed in C1-C2 segments to produce neural modulation in distant spinal segments...
  40. ncbi Noxious visceral inputs enhance cutaneous tactile response in rat thalamus
    Hong Qi Zhang
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Neurosci Lett 336:109-12. 2003
    ..The abnormal neuronal discharge in response to tactile stimulation in the condition of visceral nociception could contribute to the development of referred pain and allodynia...
  41. ncbi Substance P (NK1) and somatostatin (sst2A) receptor immunoreactivity in NTS-projecting rat dorsal horn neurones activated by nociceptive afferent input
    Filomena O Gamboa-Esteves
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    J Chem Neuroanat 27:251-66. 2004
    ..Moreover, a subpopulation of projection neurones that respond to visceral stimuli may receive somatostatinergic inputs of peripheral, local or supraspinal origins...
  42. ncbi Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats
    Magali Millecamps
    INSERM UdA E 9904, Laboratoire de Pharmacologie Medicale, Faculte de Medecine, 63001 Clermont Ferrand Cedex 1, France
    Pain 109:214-24. 2004
    ..This finding could lead to the development of a new behavioral test to assess spontaneous pain in chronic painful subjects...
  43. ncbi Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase Cbetas
    Nai Jiang Liu
    Department of Biochemistry, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Box 8, Brooklyn, NY 11203, USA
    Brain Res 1010:1-9. 2004
    ..These results could provide a mechanistic rubric for understanding positive modulation of opioid antinociception by afferent transmission...
  44. ncbi Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Cell Tissue Res 311:277-87. 2003
    ....
  45. ncbi Long-term regeneration of abdominal vagus: efferents fail while afferents succeed
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, Indiana 47907, USA
    J Comp Neurol 455:222-37. 2003
    ..Furthermore, the functional measures of disordered energy regulation did not normalize over the 45 weeks during which afferent but not efferent innervation was restored...
  46. ncbi CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intake
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 957:298-310. 2002
    ..The functional role of CART in vagal afferents and the site of food intake suppression by 4th ventricular CARTp remain to be determined...
  47. ncbi Response properties of antral mechanosensitive afferent fibers and effects of ionotropic glutamate receptor antagonists
    J N Sengupta
    Division of Gastroenterology and Hepatology, MaccFund Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 125:711-23. 2004
    ....
  48. ncbi Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs
    L Atkinson
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Neuroscience 118:115-22. 2003
    ..The lack of nNOS in vagal afferent terminals in the NTS, yet the presence in some vagal afferent cell bodies, suggests it is selectively targeted to specific regions of the same neurones...
  49. ncbi Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats
    Andreas Sandner-Kiesling
    Department of Anesthesiology and Intensive Care Medicine, Karl Franzens University, Graz, Austria
    Pain 96:13-22. 2002
    ..65 mg/kg)=ADL 10-0116 (ED50 0.60 mg/kg). These data support the use of acute UCD as a noxious stimulus, inducing afferent and reflex activity. Like other visceral stimuli, UCD is sensitive to inhibition by KOR agonists...
  50. ncbi Vaginocervical stimulation-induced release of classical neurotransmitters and nitric oxide in the nucleus of the solitary tract varies as a function of the oestrus cycle
    R Guevara-Guzman
    Departamento de Fisiologia, Facultad de Medicina, UNAM, 04510 D F, Mexico, Mexico
    Brain Res 898:303-13. 2001
    ..Our results therefore confirm that the nTS is a relay structure for the visceral afferents sending information from the uterus into the central nervous system...
  51. ncbi Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation
    Rudolf Schicho
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Brain Res 1039:108-15. 2005
    ....
  52. ncbi Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, VAGLAHS CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Pain 130:56-65. 2007
    ..In addition, we showed that stress-induced sensitization of visceral nociception is independent of 5-HT3R activation on vagal afferents...
  53. pmc Vagal afferent input alters the discharge of osmotic and ANG II-responsive median preoptic neurons projecting to the hypothalamic paraventricular nucleus
    Sean D Stocker
    Department of Physiology, University of Kentucky College of Medicine, 800 Rose St MS 508, Lexington, KY 40536 0298, USA
    Brain Res 1131:118-28. 2007
    ....
  54. ncbi Transient receptor potential vanilloid receptor-1 does not contribute to slowly adapting airway receptor activation by inhaled ammonia
    Mingyuan Wu
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Auton Neurosci 133:121-7. 2007
    ..However, when TRPV1 containing nerve endings were initially activated by RTX, the release of mediators may have affected SAR discharges...
  55. ncbi The same dorsal root ganglion neurons innervate uterus and colon in the rat
    Victor Chaban
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroreport 18:209-12. 2007
    ..These results suggest a novel form of visceral sensory integration in the dorsal root ganglion that may underlie comorbidity of many functional pain syndromes...
  56. pmc Spinal cord stimulation modulates intraspinal colorectal visceroreceptive transmission in rats
    C Qin
    Department of Physiology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73104, United States
    Neurosci Res 58:58-66. 2007
    ....
  57. ncbi Gastrocardiac afferent convergence in upper thoracic spinal neurons: a central mechanism of postprandial angina pectoris
    Chao Qin
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Pain 8:522-9. 2007
    ..These data showed that a gastric stimulus excited T3 spinal neurons with noxious cardiac input primarily by way of intraspinal ascending pathways...
  58. ncbi Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene
    J M Laird
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871, Madrid, Spain
    Neuroscience 98:345-52. 2000
    ..We propose that two separate hyperalgesia pathways exist, one of which is NK1 receptor dependent, whereas the other does not require intact substance P/NK1 signalling...
  59. ncbi Urinary bladder irritation alters efficacy of vagal stimulation on rostral medullary neurons in chronic T8 spinalized rats
    Ezidin G Kaddumi
    Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurotrauma 24:1219-28. 2007
    ..The results of this study indicate a central effect that potentially relates to some of the generalized below level pelvic visceral sensations that have been documented in patients with complete spinal cord injury...
  60. ncbi The effects of viscero-somatic interactions on thalamic mast cell recruitment in cystitic rats
    D Dubayle
    CNRS UMR 8119, Neurophysique et Physiologie Université Paris Descartes, UFR Biomedicale, 45 Rue des Saints Peres, Paris Cedex 06, France
    J Neuroimmunol 190:18-27. 2007
    ..Present data suggest that TMCs may be involved in thalamic sensory processes, including some aspects of visceral pain and abnormal visceral/somatic interactions...
  61. ncbi Involvement of metabotropic glutamate 5 receptor in visceral pain
    Erik Lindstrom
    AstraZeneca R and D, Molndal, Sweden
    Pain 137:295-305. 2008
    ..Thus, mGluR5 participates in mediating mechanically evoked visceral nociception in the gastrointestinal tract...
  62. pmc Neuromodulation of thoracic intraspinal visceroreceptive transmission by electrical stimulation of spinal dorsal column and somatic afferents in rats
    Chao Qin
    Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73910, USA
    J Pain 9:71-8. 2008
    ..ICNS suppressed excitatory responses of 9/12 spinal neurons to IB and 17/22 neurons to ED. These data showed that SCS and ICNS modulated excitatory responses of T3 spinal neurons to noxious stimulation of the heart and esophagus...
  63. pmc Sustained hypertension increases the density of AMPA receptor subunit, GluR1, in baroreceptive regions of the nucleus tractus solitarii of the rat
    Sam M Hermes
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1187:125-36. 2008
    ..These results show that hypertension alters dendritic spines containing AMPA-type glutamate receptors within NTS, suggesting that adjustments in GluR1 expression within NTS are part of the synaptic adaptations to the hypertensive state...
  64. ncbi The vagal afferent pathway does not play a major role in the induction of satiety by intestinal fatty acid in rats
    Nobuya Ogawa
    Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Lett 433:38-42. 2008
    ..In conclusion, this study indicates that the vagus nerve and the CCK signaling pathway do not play major roles in conveying satiety signals induced by intestinal LCFA to the brain in rats...
  65. ncbi Acute myocardial ischemia up-regulates nociceptin/orphanin FQ in dorsal root ganglion and spinal cord of rats
    Zheng Guo
    Department of Anesthesiology, Shanxi Medical University, 56 Xinjian Nan Road, Taiyuan 030001, Shanxi, PR China
    Neurosci Lett 433:274-8. 2008
    ..The observations indicate that cardiac noxious neural afferent drive is responsible for the up-regulation of N/OFQ in the primary afferent neurons and intrinsic spinal neurons...
  66. ncbi Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb
    A Larrazolo-López
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Delegacion Coyoacan, 04510 Ciudad Universitaria, D F, Mexico
    Neuroscience 152:585-93. 2008
    ..The vagus and pelvic nerves are responsible for carrying the information from the pelvic area to the CNS...
  67. ncbi Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain
    T Michl
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010, Graz, Austria
    Pain 92:19-27. 2001
    ....
  68. ncbi Vagal afferent input determines the volume dependence of rat esophageal motility patterns
    H Dong
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6
    Am J Physiol Gastrointest Liver Physiol 281:G44-53. 2001
    ..We conclude that load-dependent changes in distal esophagus motility pattern are encoded by vagal afferents alone and do not involve a spinal afferent input even at near-noxious stimulus strengths...
  69. ncbi Mediation by nucleus tractus solitarii glutamatergic neurotransmission of the cardiovascular reflex evoked by distal esophageal distension
    Haiheng Dong
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
    Auton Neurosci 95:24-31. 2002
    ....
  70. ncbi Morphological evidence for GABA/glycine-cocontaining terminals in synaptic contact with neurokinin-1 receptor-expressing neurons in the sacral dorsal commissural nucleus of the rat
    Yu Peng Feng
    Department of Anatomy and K K Leung Brain Research Centre, The Fourth Military Medical University, Xi an 710032, PR China
    Neurosci Lett 388:144-8. 2005
    ..These results suggested that some synaptic terminals upon NK1R-expressing SDCN neurons co-released both GABA and Gly...
  71. ncbi Noxious somatic inputs to hypothalamic-midbrain projection neurones: a comparison of the columnar organisation of somatic and visceral inputs to the periaqueductal grey in the rat
    D M Parry
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 87:117-22. 2002
    ....
  72. ncbi Vanilloid receptor type 1-immunoreactivity is expressed by intrinsic afferent neurones in the guinea-pig myenteric plexus
    Sharon Anavi-Goffer
    Department of Biomedical Science, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Neurosci Lett 319:53-7. 2002
    ..We conclude that VR1 is expressed on fibres and by myenteric neurones. In the guinea-pig, VR1 is expressed by intrinsic afferent neurones but its mRNA may differ from the rat sequence in the region of the primers...
  73. ncbi Differential processing of noxious colonic input by thoracolumbar and lumbosacral dorsal horn neurons in the rat
    Gexin Wang
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, 21201, USA
    J Neurophysiol 94:3788-94. 2005
    ..These differences may contribute to the functional dichotomy between the TL and LS spinal segments in processing acute and inflammatory colorectal pain...
  74. pmc Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats
    QiQi Zhou
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Mol Pain 2:3. 2006
    ....
  75. ncbi Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia
    H Ichikawa
    Department of Oral Function and Anatomy, Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 924:109-12. 2002
    ..The present findings may suggest that VRL-1 is associated with chemosensory functions in visceral sensory neurons...
  76. ncbi Projection sites of superficial and deep spinal dorsal horn cells in the nucleus tractus solitarii of the rat
    F O Gamboa-Esteves
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Brain Res 921:195-205. 2001
    ....
  77. ncbi Cardiovascular effects and c-Fos expression in the rat hindbrain in response to innocuous stomach distension
    Claudio Molinari
    Laboratorio di Fisiologia, 28100 Novara, Italy
    Brain Res Bull 69:140-6. 2006
    ....
  78. ncbi Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes
    Krzysztof Czaja
    Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163 6520, USA
    Brain Res 1119:86-93. 2006
    ..However, the neuronal distribution of NMDA receptor subunits is not correlated with innervation of either the stomach or duodenum...
  79. pmc Gustatory terminal field organization and developmental plasticity in the nucleus of the solitary tract revealed through triple-fluorescence labeling
    Olivia L May
    Department of Psychology, University of Virginia, Charlottesville, Virginia 22904 4400, USA
    J Comp Neurol 497:658-69. 2006
    ....
  80. ncbi Cardiovascular regulation of supraoptic vasopressin neurons
    J Thomas Cunningham
    Department of Physiology and Dalton Cardiovascular Research Center, University of Missouri Columbia, Research Park, Columbia, MO 65211, USA
    Prog Brain Res 139:257-73. 2002
    ..the activation of supraoptic oxytocin is independent of cardiac afferents and may be mediated by other visceral afferents or humoral factors...
  81. ncbi Histamine contributes to ischemia-related activation of cardiac spinal afferents: role of H1 receptors and PKC
    Liang Wu Fu
    Department of Medicine, C240 Medical Sciences I, University of California, Irvine, Irvine, CA 92697, USA
    J Neurophysiol 93:713-22. 2005
    ..is increased in coronary sinus blood during myocardial ischemia and that this autacoid stimulates abdominal visceral afferents. The present investigation evaluated the role of endogenous histamine in stimulation of ischemically ..
  82. ncbi Medullary efferent and afferent neurons of the facial nerve of the pit viper Gloydius brevicaudus
    Yoshitoshi Atobe
    Department of Neuroanatomy, Yokohama City University School of Medicine, Yokohama shi, Kanagawa Ken, 236 0004 Japan
    J Comp Neurol 472:345-57. 2004
    ..The palatine nerve also contains general somatic afferents and a very few special visceral afferents from some taste buds on the palate...
  83. ncbi Modulation of viscero-somatic H-reflex during bladder filling: a possible tool in the differential diagnosis of neurogenic voiding dysfunctions
    A Carbone
    Department of Urology, University of Rome La Sapienza, Policlinico Umberto I, Viale del Policlinico, Rome, Italy
    Eur Urol 42:281-8. 2002
    Despite evidence that the activation of visceral afferents modulates spinal motoneurone activity in humans, the circuits responsible for this modulation remain unclear...
  84. ncbi TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence
    Otto Fajardo
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    J Neurosci 28:7863-75. 2008
    ..Application of cold temperature to these visceral afferents can evoke major protective reflexes and thermoregulatory responses...
  85. pmc Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
    Paul L R Andrews
    Division of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London, SW 17 0RE, UK
    Auton Neurosci 125:100-15. 2006
    ..in humans and especially to the sensation of nausea; The stimulus coding of nausea and emesis by abdominal visceral afferents and especially the vagus-how do the afferents encode information for normal postprandial sensations, nausea ..
  86. ncbi Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying
    Helen E Raybould
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, 1321 Haring Hall, Davis, CA 95616, USA
    Am J Physiol Gastrointest Liver Physiol 284:G367-72. 2003
    ..Retrograde labeling of visceral afferents by injection of dextran-conjugated Texas Red into the duodenal wall was used to identify extrinsic primary ..
  87. ncbi Hydrogen peroxide-induced cardiovascular reflexes. Role of hydroxyl radicals
    G L Stahl
    Department of Internal Medicine, University of California, Davis 95616
    Circ Res 71:295-302. 1992
    ..These data suggest that H2O2 activates abdominal visceral afferents to reflexly stimulate the cardiovascular system by a mechanism involving hydroxyl radicals...
  88. ncbi Reactive oxygen species modify reflex cardiovascular responses to static contraction
    S Bonigut
    Department of Internal Medicine, University of California, Davis 95616, USA
    J Appl Physiol (1985) 81:1207-12. 1996
    Reactive oxygen species can reflexly activate the cardiovascular system through stimulation of abdominal visceral afferents. The mechanism appears to involve hydroxyl radicals...
  89. ncbi Glutamate receptor subunits in the nucleus of the tractus solitarius and other regions of the medulla oblongata in the cat
    R Ambalavanar
    Voice and Speech Section, NIDCD, NIH, Bethesda, Maryland 20892 1416, USA
    J Comp Neurol 402:75-92. 1998
    ..primary termination zone for laryngeal, gustatory, cardiovascular, respiratory, gastrointestinal, and other visceral afferents. Although considerable information is available on the neurochemical aspects of the NTS in general, very ..
  90. ncbi Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis
    L Y Qiao
    Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Neurogastroenterol Motil 20:928-38. 2008
    ..postulated to participate in inflammation-induced visceral hypersensitivity by modulating the sensitivity of visceral afferents through the activation of intracellular signalling pathways such as the extracellular signal-regulated ..
  91. ncbi Presynaptic inhibition in the vertebrate spinal cord revisited
    P Rudomin
    Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Apartado Postal 14 740, Mexico DF 07000, Mexico
    Exp Brain Res 129:1-37. 1999
    ..the modulation of the synaptic effectiveness of thin myelinated and unmyelinated cutaneous fibers and of visceral afferents, as well as the presynaptic control of the synaptic actions of interneurons and descending tract neurons...
  92. ncbi Immunolabeling of Mu opioid receptors in the rat nucleus of the solitary tract: extrasynaptic plasmalemmal localization and association with Leu5-enkephalin
    P Y Cheng
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Comp Neurol 371:522-36. 1996
    ..inhibitory-type) synapses but sometimes showed multiple asymmetric junctions, characteristic of excitatory visceral afferents. MOR-LI was also present along extrasynaptic plasma membranes of dendrites receiving afferent input from ..
  93. ncbi Vagal visceral inputs to the nucleus of the solitary tract: involvement in a parasympathetic reflex vasodilator pathway in the rat masseter muscle
    Hisayoshi Ishii
    Division of Physiology, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Brain Res 1312:41-53. 2010
    ..The MBF increase evoked by the vagal-parasympathetic reflex mechanism occurred via visceral afferents running in the cervical VN, but not in the abdominal VN, suggesting that the vagal visceral afferents ..
  94. ncbi Role of Barrington's nucleus in the activation of rat locus coeruleus neurons by colonic distension
    M L Rouzade-Dominguez
    Children s Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, 409 Abramson Pediatric Research Center, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Brain Res 917:206-18. 2001
    ..These results support the hypothesis that Barrington's nucleus selectively relays input from pelvic visceral afferents to the LC...
  95. pmc Comparison of baroreceptive to other afferent synaptic transmission to the medial solitary tract nucleus
    Michael C Andresen
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Am J Physiol Heart Circ Physiol 295:H2032-42. 2008
    Cranial nerve visceral afferents enter the brain stem to synapse on neurons within the solitary tract nucleus (NTS)...
  96. ncbi Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus
    James H Peters
    Department of Physiology and Pharmacolog, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Anesthesiology 108:675-83. 2008
    ..Cranial visceral afferents, which innervate the heart and lungs, synapse centrally onto neurons within the medial portion of the ..
  97. ncbi [Physiology and pathophysiology of visceral pain]
    W Janig
    Physiologisches Institut, Christian Albrechts Universitat, Kiel, Germany
    Schmerz 16:429-46. 2002
    ..It is correlated with the excitation of spinal (thoraco-lumbar, sacral) visceral afferents and (with a few exceptions) not with the excitation of vagal afferents...
  98. ncbi Afferent pathways for cardiac-somatic motor reflexes in rats
    C J Jou
    Department of Physiology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Am J Physiol Regul Integr Comp Physiol 281:R2096-102. 2001
    ..Therefore, in addition to spinothalamic convergence of somatic and visceral afferents, activation of SCA to generate spasmlike muscle contractions could account in part for anginal pain, and VCA ..
  99. ncbi Mechanism of the pressor response to intraperitoneal injection of bradykinin in guinea pigs
    J F Beauchamp
    Centre de Recherche, Hotel Dieu de Quebec, Canada
    Peptides 12:513-21. 1991
    ..IP BK in anesthetized guinea pigs are reflex in nature, involving abdominal, capsaicin-sensitive, nonvagal visceral afferents, efferent components of the sympathetic nervous system and possibly supraspinal centers, and likely to be ..
  100. ncbi Convergence of cutaneous, musculoskeletal, dural and visceral afferents onto nociceptive neurons in the first cervical dorsal horn
    C D Mørch
    Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Eur J Neurosci 26:142-54. 2007
    The convergence of cutaneous, musculoskeletal, dural and visceral afferents onto nociceptive neurons in the first cervical dorsal horn was investigated in urethane/chloralose-anesthetized rats...
  101. pmc Expression of Group I metabotropic glutamate receptors on phenotypically different cells within the nucleus of the solitary tract in the rat
    J R Austgen
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Neuroscience 159:701-16. 2009
    ..studies have shown that Group I mGluRs are present in the nucleus of the solitary tract (NTS), in which many visceral afferents terminate...

Research Grants62

  1. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..above, and 3) Generate expression profiles of Ret+ L6-S1 DRG sensory neurons to enrich isolation of bladder visceral afferents using Ret- reporter male and female postnatal mice...
  2. Phenotyping pain in a mouse model of pancreatic cancer
    Brian M Davis; Fiscal Year: 2012
    ..g. NGF, artemin, GDNF) and induces hypertrophy of visceral afferents ...
  3. Characterization and Plasticity of Visceral Nociceptors
    Brian M Davis; Fiscal Year: 2012
    ..of the GDNF family of growth factors and that these growth factors can sensitize identified, dissociated, visceral afferents. Real-time PCR and Western analysis will be used to confirm changes in growth factor expression in colon and ..
  4. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
    ..is attenuated following 12-AR activation in part through modulation of TRPV4 channels expressed on visceral afferents. This will be the first study to show TRPV4 involvement in a model of IBD and the first study to relate the ..
  5. NTS Adenosine Receptors in Cardiovascular Control
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..afferents such as arterial and cardiopulmonary baroreceptors, peripheral chemoreceptors, somatic and visceral afferents. This information is integrated and via projections to the rostral and caudal ventro-lateral medulla (..
  6. Neuronal Changes in Adult Rats Induced by Neonatal Pain
    Adrian Miranda; Fiscal Year: 2011
    ..that receive input from afferents of the superficial skin and deep somatic domain are also excited by visceral afferents. N-methyl-D-aspartate (NMDA) and neurokinin (NK) receptors may contribute to central sensitization and play ..
  7. NEURAL SUBSTRATES OF PEPTIDE INDUCED SATIETY
    Robert C Ritter; Fiscal Year: 2012
    ..The results of these experiments will expand our understanding, specifically with regard to the role of visceral afferents in cooperative control of food intake and body weight by enteroendocrine signals and leptin...
  8. Integration of Peripheral and Central Appetite Signals by Brainstem Neurons
    Suzanne M Appleyard; Fiscal Year: 2013
    ..b>Visceral afferents, including gastric afferents, carrying information about satiety terminate in the NTS...
  9. CARDIOVASCULAR EFFECTS FROM VISCERAL AFFERENTS
    John Longhurst; Fiscal Year: 1980
    ..These studies will not only elucidate the mechanisms that initiate gastric-cardiovascular reflexes but may, in addition, suggest a more rational approach toward the therapy of postprandial angina...
  10. SYMPATHETIC AND PEPTIDERGIC CONTROL OF COLON MOTILITY
    JEAN JEW; Fiscal Year: 1990
    ..P and VIP fibers in guinea pig IMG are (a) collaterals of peripheral sensory fibers from the colon or (b) visceral afferents originating from the colon...
  11. CENTRAL MONOAMINERGIC AND PEPTIDERGIC NEURONS
    VIRGINIA PICKEL; Fiscal Year: 2000
    ..sites of relevance to their role in the cardiorespiratory responses produced either by reflex activation of visceral afferents or by emotionally evoked changes in amygdaloid inputs...
  12. ALTERED NITRIC OXIDE MECHANISMS IN PVN DURING DIABETES
    Kaushik Patel; Fiscal Year: 2002
    ..that the paraventricular nucleus (PVN), a central site known to receive afferent information from various visceral afferents and to alter sympathetic outflow, may contribute to altered autonomic outflow during the diabetic state...
  13. ARTERIAL PRESSURE IN PARAPLEGIA--ROLE OF SPINAL SYSTEMS
    John Osborn; Fiscal Year: 1992
    ..The role of somatic and visceral afferents, from various spinal levels, in evoking a "hypertensive crisis" will be studied...
  14. INTERGRATIVE CONTROL OF CARDIOVASCULAR FUNCTION
    Hui Lin Pan; Fiscal Year: 2003
    ..Ischemic stimulation of visceral afferents has profound impact on systemic circulation...
  15. Effect of Neonatal Insult on Adult Visceral Afferents
    JULIE CARLSTEN CHRISTIANSON; Fiscal Year: 2006
    ..will be used to determine if permanent changes can be induced in anatomical and physiological properties of visceral afferents, causing them to become permanently sensitized and thereby establishing a state of chronic visceral ..
  16. NEUROTROPHIC CHANGES INDUCED BY INFLAMMATION OF BLADDER
    JEREMY TUTTLE; Fiscal Year: 1993
    ..will test three hypotheses concerning the pathophysiological consequences of bladder inflammation on visceral afferents. The hypotheses to be tested are: 1) Infectious, mechanical and chemical irritation of the bladder alter ..
  17. ROLE OF SUBTHALAMIC MECHANISMS IN INGESTIVE BEHAVIOR
    SEBASTIAN GROSSMAN; Fiscal Year: 1980
    ..Attempts are made to relate the effects of brainlesions to peripheral metabolic disturbances by investigating the effects of peripheral nerve transection or pharmacological blockade of visceral afferents or efferents.
  18. Glucose-Sensing and Intestinal Feedback Inhibition
    Helen Raybould; Fiscal Year: 2007
    ..A greater understanding of these sensory mechanisms will help in understanding the pathophysiology of these diseases. ..
  19. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  20. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  21. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  22. Transmission Across the First Synapse of the Baroreflex
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..These Aims will provide new and direct information about NTS that leads to a better understanding of the normal basis of the neural control of the circulation as pathophysiology. ..
  23. Early-In-Life Inflammation Effects on Urinary Bladder Sensation
    Alan Randich; Fiscal Year: 2009
    ..Translation to the treatment of painful bladder syndromes like 1C would be highly probable. ..
  24. MEDIATORS AND MODULATION OF NOCICEPTION
    Gerald Gebhart; Fiscal Year: 2008
    ..Better appreciation of these differences will enhance our understanding of the contributions these cells make to nociceptive processing, including their role in mechanisms of hyperalgesia. ..
  25. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2006
    ..By examining different anesthetics, we may also better understand whether potentially new anesthetics might be designed to spare these cardioregulatory sites. [unreadable] [unreadable]..
  26. Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
    Alan Randich; Fiscal Year: 2010
    ....
  27. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..Results from this project may contribute to a better understanding of metabolic stimuli that are sensed by the nervous system, and may elucidate neural controls that are involved in obesity, anorexia, and diabetes. ..
  28. Effects of early-in-life bladder stimulation on adults
    Alan Randich; Fiscal Year: 2004
    ..Translation to the treatment of IC would be highly probable. ..
  29. PURDUE INTEGRATIVE NEUROSCIENCE PROGRAM
    TERRY POWLEY; Fiscal Year: 2002
    ..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
  30. Presynaptic Mechanisms of Neurotransmission in NTS
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..The different sub classes of afferent nerve terminal will be also be compared in terms of their control of glutamate release and modulation by peptides. ..
  31. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..
  32. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  33. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
  34. AUTONOMIC CONTROL OF BODY WEIGHT AND FEEDING
    TERRY POWLEY; Fiscal Year: 2006
    ..abstract_text> ..
  35. Neuroanatomy of Anticipation in Anxiety Disorders
    Jack Nitschke; Fiscal Year: 2009
    ..g., anticipation that results in adaptive response) as well as understanding how dysfunction in this system occurs. ..
  36. REGULATION OF CALCIUM RELEASE IN INTESTINAL MYOCYTES
    Klaus Bielefeldt; Fiscal Year: 2002
    ..A better understanding of mechanisms that control the calcium homeostasis may provide important insight into the etiology of diseases or lead to the development of novel treatment strategies for functional abnormalities. ..
  37. Interaction torques in voluntary turning and reaching
    James R Lackner; Fiscal Year: 2010
    ..The experimental findings and analyses will provide a comprehensive evaluation of the role of feedforward predictive mechanisms in the control of reaching movements involving body rotation. ..
  38. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  39. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 2008
    ..Results will also aid in guiding the design of new drugs and physiologically-based strategies for treating obesity as well as other, feeding-related pathologies. ..
  40. NEUROBIOLOGY OF TRANSITION TO STIMULANT DEPENDENCE
    Martin P Paulus; Fiscal Year: 2010
    ..g. using real-time fMRI?? ..
  41. Cognitive and affective influences on taste processing
    Dana M Small; Fiscal Year: 2010
    ..This research will provide fundamental information about human gustation and it will provide important baseline data for future studies of gustatory processing in the obese and individuals with an eating, drug or alcohol disorder. ..
  42. Corticotropin Releasing Factor-Norepinephrine Interactions in Stress & Depression
    ADRIAN DUNN; Fiscal Year: 2008
    ..The results should establish a model and indicate the nature of the cerebral structures involved, so that we can subsequently test the feed-forward hypothesis [unreadable] [unreadable]..
  43. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  44. Forebrain Neurohumoral Integration in Heart Failure
    SEAN STOCKER; Fiscal Year: 2005
    ....
  45. Uterus & Colon Influences on Bladder Function in Females
    Karen Berkley; Fiscal Year: 2004
    ..Results from these exploratory studies will be then be used to develop a longer program of research. ..
  46. Parabrachial Nucleus and Feeding
    Radmila Trifunovic; Fiscal Year: 2004
    ..abstract_text> ..
  47. Developmental Affects of Ritalin on Brain
    TERESA MILNER; Fiscal Year: 2004
    ..Determining how therapeutic dosage regimens effect these transmitter systems is critical in understanding the safety of long-term therapeutic doses of MPH administered to children and adolescents with ADHD and other related disorders. ..
  48. Ribonucleotide monophosphates and umami taste
    Eugene Delay; Fiscal Year: 2003
    ..If IMP and GMP have identical taste qualities, and these qualities are the same as MSG and the other "umami" substance. ..
  49. PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVE
    Linda Hayward; Fiscal Year: 2002
    ..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
  50. Neural and Immune Cell Interactions: Two of a Kind
    LISA GOEHLER; Fiscal Year: 2002
    ..Finally, the interactions between immune and neural cells may well be bi-directional, providing a novel mechanism by which neural activity can modulate immune cell functions. ..
  51. Taste circuits in hypothalamus
    Theresa Harrison; Fiscal Year: 2005
    ..The results of these studies will further our understanding of how the taste of food influences the brain's complex, interacting circuitry controlling eating, body weight and energy expenditure. ..
  52. L-amino and acid taste in mice.
    Eugene Delay; Fiscal Year: 2005
    ..g., diabetics, cardiovascular disease, aged). ..
  53. STIMULANT DEPENDENCE: NEURAL MECHANISMS OF RELAPSE
    Martin Paulus; Fiscal Year: 2008
    ..This project will link systems neuroscience with clinical research in substance use disorders thereby providing cognitive neuroscience and neuroimaging insights into dysfunctions associated with substance use disorders. ..
  54. Alterations in chemoafferent integration induced by chronic intermittent hypoxia
    STEVEN MIFFLIN; Fiscal Year: 2008
    ..These factors mediate much of the pathology associated with sleep apnea including hypertension, increased risk of adverse cardiovascular events and insulin resistance. [unreadable] [unreadable] [unreadable]..
  55. Role of NTS POMC neurons in energy homeostasis
    SUZANNE APPLEYARD; Fiscal Year: 2008
    ..abstract_text> ..
  56. Interactions Between Nicotine Addiction and Food Reward
    DANA SMALL; Fiscal Year: 2006
    ..If brain response does predict weight gain then we will have developed a method to identify individuals at risk for relapse so that they can be targeted for further therapeutic intervention. [unreadable] [unreadable] [unreadable]..
  57. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
  58. Functional Neuroimaging in Anxiety and Fear
    Jack Nitschke; Fiscal Year: 2006
    ..abstract_text> ..
  59. CI-2 Modulation of Spinal Processes: Supraspinal Effects
    Robert Foreman; Fiscal Year: 2006
    ..abstract_text> ..
  60. Glucocorticoid Receptor Mechanisms, Stress and Aging
    James Herman; Fiscal Year: 2006
    ..abstract_text> ..
  61. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    ....