olfactory pathways

Summary

Summary: Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. It includes the OLFACTORY NERVE; OLFACTORY BULB; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex. The term rhinencephalon is restricted to structures in the CNS receiving fibers from the olfactory bulb.

Top Publications

  1. ncbi Olfaction: diverse species, conserved principles
    Barry W Ache
    Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Neuron 48:417-30. 2005
  2. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
  3. ncbi Molecular, anatomical, and functional organization of the Drosophila olfactory system
    Africa Couto
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
    Curr Biol 15:1535-47. 2005
  4. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
  5. ncbi Representations of odor in the piriform cortex
    Dan D Stettler
    Department of Neuroscience and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 63:854-64. 2009
  6. pmc Divisive normalization in olfactory population codes
    Shawn R Olsen
    Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA
    Neuron 66:287-99. 2010
  7. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
  8. pmc Cellular-resolution population imaging reveals robust sparse coding in the Drosophila mushroom body
    Kyle S Honegger
    Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 31:11772-85. 2011
  9. ncbi Neuronal filtering of multiplexed odour representations
    Francisca Blumhagen
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nature 479:493-8. 2011
  10. pmc Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations
    Cindy Poo
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 62:850-61. 2009

Research Grants

  1. Anterior Olfactory Nucleus
    Peter C Brunjes; Fiscal Year: 2013
  2. EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE & PARKINSONISM
    RICHARD DOTY; Fiscal Year: 1991
  3. Role of Arrestin in Olfactory Desensitization
    CATHERINE MERRILL; Fiscal Year: 2003
  4. Neural Development: Intercellular and Humoral Control
    Richard Levine; Fiscal Year: 2005
  5. ANATOMICAL BASIS OF OLFACTORY DISCRIMINATION
    Burton Slotnick; Fiscal Year: 1980
  6. Chemosensory activation of amygdala: Modulation by GnRH
    CAMILLE BLAKE; Fiscal Year: 2006
  7. GENETIC & MOLECULAR ANALYSIS OF DROSOPHILA OLFACTION
    John Carlson; Fiscal Year: 1993
  8. Ensemble coding in olfactory cortex
    Donald Wilson; Fiscal Year: 2006
  9. Cholinergic modulation of olfactory processing
    Christiane Linster; Fiscal Year: 2007
  10. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010

Detail Information

Publications303 found, 100 shown here

  1. ncbi Olfaction: diverse species, conserved principles
    Barry W Ache
    Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    Neuron 48:417-30. 2005
    ..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors...
  2. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
    ..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
  3. ncbi Molecular, anatomical, and functional organization of the Drosophila olfactory system
    Africa Couto
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
    Curr Biol 15:1535-47. 2005
    ..A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at single-cell resolution...
  4. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
    ....
  5. ncbi Representations of odor in the piriform cortex
    Dan D Stettler
    Department of Neuroscience and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 63:854-64. 2009
    ..This representation suggests organizational principles that differ from those in neocortical sensory areas where cells responsive to similar stimulus features are clustered and response properties vary smoothly across the cortex...
  6. pmc Divisive normalization in olfactory population codes
    Shawn R Olsen
    Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA
    Neuron 66:287-99. 2010
    ....
  7. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
    ..We propose a model describing how these receptors might be used by a male to distinguish suitable from unsuitable mating partners through a simple logic...
  8. pmc Cellular-resolution population imaging reveals robust sparse coding in the Drosophila mushroom body
    Kyle S Honegger
    Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 31:11772-85. 2011
    ..Our results indicate that the fundamental feature of odor processing in the MB is to create sparse stimulus representations in a format that facilitates arbitrary associations between odor and punishment or reward...
  9. ncbi Neuronal filtering of multiplexed odour representations
    Francisca Blumhagen
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nature 479:493-8. 2011
    ..These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes...
  10. pmc Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations
    Cindy Poo
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 62:850-61. 2009
    ..Together, our results reveal that global inhibition and oscillations are major synaptic mechanisms shaping odor representations in olfactory cortex...
  11. pmc Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex
    Kei M Igarashi
    Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 32:7970-85. 2012
    ..Surprisingly, in anterior OC areas, the two cell types projected to segregated subareas. These results suggest that MCs and TCs transmit temporally distinct odor information to different OC targets...
  12. pmc Functional analysis of a higher olfactory center, the lateral horn
    Nitin Gupta
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:8138-48. 2012
    ..Our results rather point to three other possible roles of LHNs: extracting general stimulus features such as odor intensity; mediating bilateral integration of sensory information; and integrating multimodal sensory stimuli...
  13. ncbi Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish
    Yuki Sato
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Neurosci 25:4889-97. 2005
    ....
  14. ncbi Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulb
    Kevin M Cury
    Department of Molecular and Cellular Biology, Harvard University, Center for Brain Science, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 68:570-85. 2010
    ..These results suggest that inhalation-coupled transient activity forms a robust neural code that is invariant to changes in respiration behavior...
  15. ncbi How is the olfactory map formed and interpreted in the mammalian brain?
    Kensaku Mori
    Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Annu Rev Neurosci 34:467-99. 2011
    ....
  16. ncbi Naris occlusion alters the electro-olfactogram: evidence for compensatory plasticity in the olfactory system
    Christopher T Waggener
    Department of Biology, Randolph Macon College, Ashland, VA 23005, USA
    Neurosci Lett 427:112-6. 2007
    ..These results provide the most direct support, to date, for compensatory plasticity in the olfactory system...
  17. ncbi Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
    Fuqiang Xu
    Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA
    J Comp Neurol 489:491-500. 2005
    ..fMRI results demonstrate that both the main and the accessory olfactory systems may respond to volatile compounds but with different selectivity, suggesting a greater integration of the two olfactory pathways than traditionally believed.
  18. pmc Lateral presynaptic inhibition mediates gain control in an olfactory circuit
    Shawn R Olsen
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 452:956-60. 2008
    ..A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal...
  19. ncbi Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry
    L B Haberly
    Department of Anatomy and Neuroscience Program, University of Wisconsin, Madison, WI 53706, USA
    Chem Senses 26:551-76. 2001
    ....
  20. pmc Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb
    Ryan M Carey
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 31:10615-26. 2011
    ....
  21. ncbi A novel multigene family may encode odorant receptors: a molecular basis for odor recognition
    L Buck
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 65:175-87. 1991
    ..The members of this novel gene family are likely to encode a diverse family of odorant receptors...
  22. pmc Cortical processing of odor objects
    Donald A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuron 72:506-19. 2011
    ..Recent findings regarding the neural architecture, physiology, and plasticity of the olfactory cortex, principally the piriform cortex, will be described in the context of how this paleocortical structure creates odor objects...
  23. ncbi Axonal wiring in the mouse olfactory system
    Peter Mombaerts
    Rockefeller University, New York, New York 10021, USA
    Annu Rev Cell Dev Biol 22:713-37. 2006
    ..ORs determine both the odorant response profile of the OSN and the projection of its axon to a specific glomerulus. I focus on genetic approaches to the axonal wiring problem, particularly on how ORs may function in axonal wiring...
  24. ncbi The accessory olfactory bulb in the adult rat: a cytological study of its cell types, neuropil, neuronal modules, and interactions with the main olfactory system
    Jorge Larriva-Sahd
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, CP 76001 Qro, Mexico
    J Comp Neurol 510:309-50. 2008
    ..Because IGCs are a well-known source of modulatory inputs to LPCs, both MACs and INBs represent a site of convergence of the MOB with the AOB...
  25. pmc Odor representations in olfactory cortex: distributed rate coding and decorrelated population activity
    Keiji Miura
    Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 74:1087-98. 2012
    ..These findings demonstrate profound transformations in the dynamics of odor representations from the olfactory bulb to cortex and reveal likely substrates for odor-guided decisions...
  26. pmc A presynaptic gain control mechanism fine-tunes olfactory behavior
    Cory M Root
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 59:311-21. 2008
    ..These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs...
  27. ncbi Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons
    John P McGann
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Neuron 48:1039-53. 2005
    ..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity...
  28. ncbi Intrinsic membrane properties and inhibitory synaptic input of kenyon cells as mechanisms for sparse coding?
    Heike Demmer
    University of Cologne, Institute of Zoology and Physiology, Center for Molecular Medicine Cologne, CECAD, Weyertal 119, 50931 Cologne, Germany
    J Neurophysiol 102:1538-50. 2009
    ....
  29. pmc Asymmetric neurotransmitter release enables rapid odour lateralization in Drosophila
    Quentin Gaudry
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 493:424-8. 2013
    ..Our data also show that small differences in spike timing and spike rate can produce reliable differences in olfactory behaviour...
  30. ncbi Organization of deutocerebral neuropils and olfactory behavior in the centipede Scutigera coleoptrata (Linnaeus, 1758) (Myriapoda: Chilopoda)
    Andy Sombke
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll Straße 8, 07745 Jena, Germany
    Chem Senses 36:43-61. 2011
    ..These results are in line with the morphological findings concerning the well-developed olfactory centers in the deutocerebrum of this species...
  31. ncbi Pre-target axon sorting establishes the neural map topography
    Takeshi Imai
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
    Science 325:585-90. 2009
    ..Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons...
  32. ncbi Parallel olfactory systems in insects: anatomy and function
    C Giovanni Galizia
    University of Konstanz, Konstanz, Germany
    Annu Rev Entomol 55:399-420. 2010
    ..In this paper, we review the situation across insect species and offer hypotheses for the function and evolution of parallel olfactory systems...
  33. ncbi Representation of odorants by receptor neuron input to the mouse olfactory bulb
    M Wachowiak
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 32:723-35. 2001
    ..Finally, odorant activation slopes could differ across glomeruli, and for different odorants activating the same glomerulus. These results imply a high degree of complexity in odorant representations at the level of olfactory bulb input...
  34. ncbi Olfactory coding with patterns of response latencies
    Stephan Junek
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Neuron 67:872-84. 2010
    ..Our results suggest that the latency patterns of M/T cells contain all the information higher brain centers need to identify odors and their concentrations...
  35. ncbi The neurobiology of insect olfaction: sensory processing in a comparative context
    JOSHUA P MARTIN
    Department of Neuroscience, College of Science, University of Arizona, 1040 East Fourth Street, Tucson, AZ 85721 0077, USA
    Prog Neurobiol 95:427-47. 2011
    ..We propose that this perspective is beneficial for insect olfactory neurobiology in particular and sensory neurobiology in general...
  36. ncbi Olfactory representations by Drosophila mushroom body neurons
    Glenn C Turner
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Neurophysiol 99:734-46. 2008
    ..By comparing activity patterns evoked by the same odors across olfactory receptor neurons and across KCs, we show that representations of different odors do indeed become less correlated as they progress through the olfactory system...
  37. ncbi Precise olfactory responses tile the sniff cycle
    Roman Shusterman
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
    Nat Neurosci 14:1039-44. 2011
    ..The temporal specificity of mitral/tufted cell output provides a potentially rich source of information for downstream olfactory areas...
  38. pmc Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination
    Alexander Fleischmann
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 60:1068-81. 2008
    ..The M71 transgenic mice readily detect other odors in the presence of acetophenone. These observations have implications for how receptor activation in the periphery is represented in the brain and how these representations encode odors...
  39. ncbi Mice deficient in G(olf) are anosmic
    L Belluscio
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neuron 20:69-81. 1998
    ..These behavioral phenotypes, taken together with the patterns of G(olf) expression, suggest that G(olf) is required for olfactory signal transduction and may also function as an essential signaling molecule more centrally in the brain...
  40. pmc Olfactory perception: receptors, cells, and circuits
    Chih Ying Su
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 139:45-59. 2009
    ..Here, we discuss the insight that has been gained into the receptors, cells, and circuits that underlie the sense of smell...
  41. pmc Odor quality coding and categorization in human posterior piriform cortex
    James D Howard
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:932-8. 2009
    ..These findings substantiate theoretical models emphasizing the importance of distributed piriform templates for the perceptual reconstruction of odor object quality...
  42. ncbi Coding and synaptic processing of sensory information in the glomerular layer of the olfactory bulb
    Matt Wachowiak
    Department of Biology, Boston University, Boston, MA 02215, USA
    Semin Cell Dev Biol 17:411-23. 2006
    ..We speculate that odor representations and their postsynaptic processing are tuned to and shaped by the sniffing behavior of the animal...
  43. ncbi State-dependent sensory gating in olfactory cortex
    Masayoshi Murakami
    Department of Physiology, Graduate School of Medicine, School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuron 46:285-96. 2005
    ..They suggest a state-dependent switchover of signal processing modes in the olfactory cortex...
  44. ncbi New insights into an ancient insect nose: the olfactory pathway of Lepismachilis y-signata (Archaeognatha: Machilidae)
    Christine Missbach
    Max Planck Institute for Chemical Ecology, Department of Neuroethology, Hans Knoll Strasse 8, D 07745 Jena, Germany
    Arthropod Struct Dev 40:317-33. 2011
    ..The connection of the glomerular neuropils to higher brain centers remains unclear and mushroom bodies are absent as reported from other archaeognathan species. We discuss the evolutionary implications of these findings...
  45. ncbi Postnatal refinement of peripheral olfactory projections
    Dong Jing Zou
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:1976-9. 2004
    ..Persistence may be due, in part, to prolonged survival of olfactory sensory neurons...
  46. ncbi Trigeminal collaterals in the nasal epithelium and olfactory bulb: a potential route for direct modulation of olfactory information by trigeminal stimuli
    Michele L Schaefer
    Department of Cellular and Structural Biology and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Comp Neurol 444:221-6. 2002
    ..Furthermore, the collateral innervation of the epithelium and bulb may provide an avenue whereby nasal irritants could affect processing of coincident olfactory stimuli...
  47. ncbi From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish
    Nobuhiko Miyasaka
    Laboratories for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 29:4756-67. 2009
    ..Moreover, our finding of asymmetric bulbo-habenular projection renders the olfactory system an attractive model for the studies of brain asymmetry and lateralized behaviors...
  48. ncbi Mushroom body memoir: from maps to models
    Martin Heisenberg
    Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nat Rev Neurosci 4:266-75. 2003
  49. pmc Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish
    Tetsuya Koide
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 106:9884-9. 2009
    ..Thus, the integrated approach combining genetic, neuroanatomical, and behavioral methods enables us to elucidate the neural circuit mechanism underlying various olfactory behaviors in adult zebrafish...
  50. ncbi Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage
    Elise Cau
    IGBMC, 1 rue Laurent Fries, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 129:1871-80. 2002
    ..These results illustrate the versatility of neural bHLH genes which adopt either a determination or a differentiation function, depending primarily on the timing of their expression in neural progenitors...
  51. ncbi Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulb
    Kazunari Miyamichi
    Core Research for Evolutional Science and Technology, The University of Tokyo, Tokyo 113 0032, Japan
    J Neurosci 25:3586-92. 2005
    ..The present study indicates that the OR gene choice may be more restricted by the OSN location in the OE than what has been thought...
  52. ncbi Neural map formation in the mouse olfactory system
    Hitoshi Sakano
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
    Neuron 67:530-42. 2010
    ..Here, we review the recent progress on the study of olfactory map formation in rodents. We will discuss how neuronal identity is represented at axon termini and how the OR-instructed axonal projection is regulated...
  53. ncbi Target neuron prespecification in the olfactory map of Drosophila
    G S Jefferis
    Neurosciences Program, Department of Biological Sciences, Stanford University, CA 94305, USA
    Nature 414:204-8. 2001
    ..These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity...
  54. ncbi Serotonergic modulation of odor input to the mammalian olfactory bulb
    Gabor C Petzold
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    Nat Neurosci 12:784-91. 2009
    ..Our data indicate that the serotonergic system regulates odor inputs in the olfactory bulb and suggest that behavioral states may alter odor processing at the earliest stages...
  55. ncbi Subsystem organization of the mammalian sense of smell
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 71:115-40. 2009
    ..An integrative approach that includes gene targeting methods, optical and electrophysiological recording, and behavioral analysis has helped to elucidate the functional significance of this subsystem organization for the sense of smell...
  56. ncbi The coding of odour-intensity in the honeybee antennal lobe: local computation optimizes odour representation
    Silke Sachse
    Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Str 28 30, 14195 Berlin, Germany
    Eur J Neurosci 18:2119-32. 2003
    ....
  57. ncbi Odorant receptors govern the formation of a precise topographic map
    F Wang
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 93:47-60. 1998
    ..These data, along with additional receptor substitutions, indicate that the odorant receptor plays an instructive role in the establishment of the topographic map...
  58. ncbi Function and morphology of the antennal lobe: new developments
    B S Hansson
    Department of Ecology, Lund University, Sweden
    Annu Rev Entomol 45:203-31. 2000
    ....
  59. pmc Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map
    Weizhe Hong
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 12:1542-50. 2009
    ..The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation...
  60. ncbi Molecular detection of pheromone signals in mammals: from genes to behaviour
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 4:551-62. 2003
  61. pmc Temporally diverse firing patterns in olfactory receptor neurons underlie spatiotemporal neural codes for odors
    Baranidharan Raman
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:1994-2006. 2010
    ..Thus, our results demonstrate the origin and subsequent reformatting of spatiotemporal neural codes for odors...
  62. ncbi The olfactory granule cell: from classical enigma to central role in olfactory processing
    Gordon M Shepherd
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Brain Res Rev 55:373-82. 2007
    ..Among other important properties, granule cells undergo neurogenesis from precursor cells throughout adult life. This originally enigmatic cell thus appears to play a critical role in olfactory processing...
  63. pmc Characterization and coding of behaviorally significant odor mixtures
    Jeffrey A Riffell
    University of Arizona, Tucson, 85721, USA
    Curr Biol 19:335-40. 2009
    ....
  64. ncbi A map of olfactory representation in the Drosophila mushroom body
    Hui Hao Lin
    Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan, ROC
    Cell 128:1205-17. 2007
    ..Our data suggest that olfactory coding at the AL is decoded in the MB and then transferred via distinct lobes to separate higher brain centers...
  65. ncbi Precision and diversity in an odor map on the olfactory bulb
    Edward R Soucy
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 12:210-20. 2009
    ..This local diversity of sensory tuning stands in marked distinction from other brain maps. Given the reliable placement of the glomeruli, it represents a feature, not a flaw, of the olfactory bulb...
  66. ncbi Development of the Drosophila olfactory system
    Veronica Rodrigues
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
    Adv Exp Med Biol 628:82-101. 2008
    ....
  67. ncbi Behavioral state regulation of dendrodendritic synaptic inhibition in the olfactory bulb
    Yusuke Tsuno
    Department of Physiology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 28:9227-38. 2008
    ..These results provide evidence that behavioral state-dependent global changes in cholinergic tone modulate dendrodendritic synaptic inhibition and the information processing mode in the olfactory bulb...
  68. ncbi High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation
    Michael E Hasselmo
    Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, USA
    Prog Brain Res 145:207-31. 2004
  69. ncbi Spatiotemporal representations in the olfactory system
    Andreas T Schaefer
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Trends Neurosci 30:92-100. 2007
    ..Based on such evidence, we have devised a working model to assess further the relevance of such spatiotemporal processes in odour representation...
  70. pmc Testing odor response stereotypy in the Drosophila mushroom body
    Mala Murthy
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 59:1009-23. 2008
    ....
  71. ncbi Mesenchymal/epithelial induction mediates olfactory pathway formation
    A S LaMantia
    Department of Cell and Molecular Physiology and Center for Neuroscience, The University of North Carolina at Chapel Hill, Medical School, 27599, USA
    Neuron 28:411-25. 2000
    ..Thus, a cellular and molecular mechanism that facilitates musculoskeletal and vascular development elsewhere in the embryo has been adapted to guide the differentiation of the olfactory pathway in the developing forebrain...
  72. ncbi Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
    Hayan Yoon
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 123:669-82. 2005
    ..Further visualization of afferents to LHRH neurons across the brain offers a unique opportunity to uncover complex polysynaptic circuits modulating reproduction and fertility...
  73. ncbi Olfactory conditioning of proboscis activity in Drosophila melanogaster
    Marie Ange Chabaud
    Developpement, Evolution et Plasticité du Système Nerveux, CNRS, Bat 32 33, Avenue de la Terrasse, 91198, Gif sur Yvette Cedex, France
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:1335-48. 2006
    ..We also showed that learning performance was dependent on food motivation, by comparing flies subjected to different starvation regimes...
  74. ncbi Hierarchical regulation of odorant receptor gene choice and subsequent axonal projection of olfactory sensory neurons in zebrafish
    Yuki Sato
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 27:1606-15. 2007
    ..These data demonstrate two distinct modes of OR expression and suggest a model of the hierarchical regulation of OR gene choice and subsequent axonal projection in the zebrafish olfactory system...
  75. ncbi Functional neuronal processing of body odors differs from that of similar common odors
    Johan N Lundstrom
    Department of Psychology, McGill University, Montreal, QC, H3A1B1, Canada
    Cereb Cortex 18:1466-74. 2008
    ..The results provide evidence that social olfactory stimuli of high ecological relevance are processed by specialized neuronal networks similar to what has previously been demonstrated for auditory and visual stimuli...
  76. ncbi Differential neural responses evoked by orthonasal versus retronasal odorant perception in humans
    Dana M Small
    The John B Pierce Laboratory, New Haven, Connecticut 06519, USA
    Neuron 47:593-605. 2005
    ..These findings demonstrate differential neural recruitment depending upon the route of odorant administration and suggest that its effect is influenced by whether an odorant represents a food...
  77. pmc Behavioral consequences of innate preferences and olfactory learning in hawkmoth-flower interactions
    Jeffrey A Riffell
    Division of Neurobiology and Center for Insect Science, Arizona Research Laboratories, and Departments of Chemistry and Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 105:3404-9. 2008
    ..Behavioral flexibility and the olfactory contrast between flowers permit the hawkmoths to persist within a dynamic environment, while at the same time to function as the major pollinator of one plant species...
  78. ncbi Genetic analysis of brain circuits underlying pheromone signaling
    C Dulac
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Genet 40:449-67. 2006
    ..We will review and discuss the specific contribution of each of the two chemosensory systems that ensure specific behavioral responses to conspecific animals...
  79. ncbi Morphological and functional plasticity of olfactory ensheathing cells
    Adele J Vincent
    NeuroRepair Group, Discipline of Anatomy and Physiology, University of Tasmania Hobart, Private Bag 24, Tasmania, Australia 7001
    J Neurocytol 34:65-80. 2005
    ..Finally, we will explore the possibility that recent microarray data could point to OECs assuming an innate immune function or playing a role in modulating neuroinflammation...
  80. ncbi Histological and ultrastructural characteristics of the primordial vomeronasal organ in lungfish
    Shoko Nakamuta
    Laboratory of Veterinary Anatomy, Faculty of Agriculture, Iwate University, Morioka, Iwate 020 8550, Japan
    Anat Rec (Hoboken) 295:481-91. 2012
    ..This study may provide important clues to elucidate how the vomeronasal organ emerged during the evolution of vertebrates...
  81. ncbi Distribution and functional organization of glomeruli in the olfactory bulbs of zebrafish (Danio rerio)
    Oliver R Braubach
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
    J Comp Neurol 520:2317-39, Spc1. 2012
    ..Collectively, our results provide a uniquely detailed description of a vertebrate olfactory system and highlight anatomically distinct parallel neural pathways that mediate early aspects of olfactory processing in the zebrafish...
  82. ncbi Parallel processing via a dual olfactory pathway in the honeybee
    Martin F Brill
    Department of Behavioral Physiology and Sociobiology, Biozentrum, University of Wurzburg, 97074 Wurzburg, Germany
    J Neurosci 33:2443-56. 2013
    ....
  83. ncbi Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex
    Hyun H Kim
    Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:9548-59. 2006
    ..In summary, the present study provides an initial characterization of the molecular mechanisms associated with odor stimulation on second order neuronal plasticity and phenotype in the olfactory system...
  84. ncbi Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice
    Diego Restrepo
    Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Horm Behav 46:247-56. 2004
    ..In each case, one system or the other (or both) participates in a specific behavioral or hormonal response...
  85. pmc Brain architecture in the terrestrial hermit crab Coenobita clypeatus (Anomura, Coenobitidae), a crustacean with a good aerial sense of smell
    Steffen Harzsch
    Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Beutenberg Campus, Hans Knöll Str, 8, D 07745 Jena, Germany
    BMC Neurosci 9:58. 2008
    ....
  86. ncbi Expanded endoscopic endonasal resection of an olfactory schwannoma
    Hilal A Kanaan
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg Pediatr 2:261-5. 2008
    ....
  87. ncbi Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variability
    Anna Brochtrup
    Institut fur Neurobiologie, Universitat Munster, Badestr 9, D 48149 Munster, Germany
    Curr Opin Neurobiol 21:85-92. 2011
    ..Recent findings revealed an astonishing morphological diversity among members of the same interneuron class, suggesting an unexpected variability in local microcircuits involved in insect sensory processing...
  88. ncbi Centrifugal innervation of the mammalian olfactory bulb
    Shinji Matsutani
    Department of Functional Morphology, Kitasato University School of Nursing, Kanagawa, Japan
    Anat Sci Int 83:218-27. 2008
    ....
  89. ncbi Solitary olfactory groove schwannoma
    Giuseppe Mirone
    Neurosurgery, Department of Neurological Sciences, c o Ospedale CTO, Second University of Naples, Viale Colli Aminei 21, 80131 Naples, Italy
    J Clin Neurosci 16:454-6. 2009
    ..We briefly review the pertinent literature, stress the distinctive clinical and neuroradiological findings and discuss the surgical planning and theories about the pathogenesis of schwannomas in this unusual location...
  90. ncbi Local interneuron diversity in the primary olfactory center of the moth Manduca sexta
    Carolina E Reisenman
    Department of Neuroscience, University of Arizona, Tucson, 85721, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 197:653-65. 2011
    ..These results show that, as observed in other insects, LNs are diverse, which likely determines the complexity of the inhibitory network that regulates AL output...
  91. pmc Chemotopic odorant coding in a mammalian olfactory system
    Brett A Johnson
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    J Comp Neurol 503:1-34. 2007
    ..A critical analysis suggests that alternative coding mechanisms for odor quality, such as those based on temporal patterns of responses, enjoy little experimental support...
  92. ncbi Dynamical encoding by networks of competing neuron groups: winnerless competition
    M Rabinovich
    Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093-0402, USA
    Phys Rev Lett 87:068102. 2001
    ..e., much larger than that of most traditional network structures. We show that a small winnerless competition network composed of FitzHugh-Nagumo spiking neurons efficiently transforms input information into a spatiotemporal output...
  93. ncbi The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
    Sonoko Hasegawa
    KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Mol Cell Neurosci 38:66-79. 2008
    ..Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb...
  94. ncbi Dissociable codes of odor quality and odorant structure in human piriform cortex
    Jay A Gottfried
    Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, Illinois 60611, USA
    Neuron 49:467-79. 2006
    ..In turn, quality-based codes are independent of any simple structural configuration, implying that synthetic mechanisms may underlie our experience of smell...
  95. ncbi Insect olfaction: receptors, signal transduction, and behavior
    K Sato
    Department of Integrated Biosciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba, 277 8562, Japan
    Results Probl Cell Differ 47:121-38. 2009
    ..The understanding of the molecular mechanism of insect olfaction will help in the development of insect repellents for controlling insect pest and vector populations for a wide range of pathogens...
  96. pmc Olfactory perceptual stability and discrimination
    Dylan C Barnes
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, Oklahoma 73019, USA
    Nat Neurosci 11:1378-80. 2008
    ..This piriform cortical ensemble activity predicts olfactory perception...
  97. pmc Olfactory modulation of flight in Drosophila is sensitive, selective and rapid
    Vikas Bhandawat
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Biol 213:3625-35. 2010
    ..This makes these behaviors a useful paradigm for studying the relationship between sensory neuron activity and behavioral decision-making in a simple and genetically tractable organism...
  98. ncbi Encoding a temporally structured stimulus with a temporally structured neural representation
    Stacey L Brown
    National Institute of Child Health and Human Development, US National Institutes of Health, Building 35, Room 3A 102, Bethesda, Maryland 20892, USA
    Nat Neurosci 8:1568-76. 2005
    ..Thus, ensemble-based spatiotemporal coding could disambiguate complex and potentially confounding temporally structured sensory stimuli and thereby provide an invariant response to a stimulus presented in various ways...
  99. ncbi Functional neuroimaging of odor imagery
    J Djordjevic
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neuroimage 24:791-801. 2005
    ..Overall, the findings indicated that neural networks engaged during odor perception and imagery overlap partially...
  100. pmc Associative conditioning tunes transient dynamics of early olfactory processing
    Patricia C Fernandez
    Arizona State University, School of Life Sciences, Tempe, AZ 85287 4501, USA
    J Neurosci 29:10191-202. 2009
    ..AL activity was modified by conditioning to improve separation of odor representations. These data suggest that one role of reinforcement is to "tune" the AL such that relevant odors become more discriminable...
  101. pmc Aversive learning enhances perceptual and cortical discrimination of indiscriminable odor cues
    Wen Li
    Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 319:1842-5. 2008
    ..That completely indiscriminable sensations can be transformed into discriminable percepts further accentuates the potency of associative learning to enhance sensory cue perception and support adaptive behavior...

Research Grants62

  1. Anterior Olfactory Nucleus
    Peter C Brunjes; Fiscal Year: 2013
    ..described in the present proposal is designed to examine carefully a very important region in the central olfactory pathways. The anterior olfactory nucleus (AON) has synaptic connections at nearly every point of information ..
  2. EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE & PARKINSONISM
    RICHARD DOTY; Fiscal Year: 1991
    ..visual, somatosensory, and motor pathways, significant numbers of neurofibrillary tangles are found in the olfactory pathways of AD brains, particularly regions receiving direct projections from the olfactory bulb, including the uncus ..
  3. Role of Arrestin in Olfactory Desensitization
    CATHERINE MERRILL; Fiscal Year: 2003
    ..such as odorant receptors), these studies will initially investigate the role of arrestin genes in olfactory pathways using established mutants in the well-characterized Drosophila melanogaster model system...
  4. Neural Development: Intercellular and Humoral Control
    Richard Levine; Fiscal Year: 2005
    ..in olfactory receptor neuron sorting and in formation of glomerular compartments during development of olfactory pathways; (3) steroid-hormonal regulation of development of identified motor neurons in vivo and in primary cell ..
  5. ANATOMICAL BASIS OF OLFACTORY DISCRIMINATION
    Burton Slotnick; Fiscal Year: 1980
    ..Functions of secondary olfactory pathways in odor detection, detection threshold, intensity difference threshold and 2-odor discrimination will be ..
  6. Chemosensory activation of amygdala: Modulation by GnRH
    CAMILLE BLAKE; Fiscal Year: 2006
    ..Chemosensory signals received during mating activate brain regions along the vomeronasal and main olfactory pathways. These activated regions contain cell bodies and fibers of gonadotropin-releasing hormone (GnRH) neurons...
  7. GENETIC & MOLECULAR ANALYSIS OF DROSOPHILA OLFACTION
    John Carlson; Fiscal Year: 1993
    ..Such mutants define genes which may play roles in chemically-specific olfactory pathways; these genes could encode olfactory receptor molecules or other products required for transduction or ..
  8. Ensemble coding in olfactory cortex
    Donald Wilson; Fiscal Year: 2006
    ..This combination is ideally suited for the R21 mechanism. ..
  9. Cholinergic modulation of olfactory processing
    Christiane Linster; Fiscal Year: 2007
    ..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. [unreadable] [unreadable] [unreadable]..
  10. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010
    ..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
  11. Cholinergic modulation of odor responses
    Christiane Linster; Fiscal Year: 2003
    ....
  12. Conf Proposal:Gordon Research Conf on Neuroethology 2005
    NICHOLAS STRAUSFELD; Fiscal Year: 2005
    ..The conference is intended for the broad neuroethological community at all professional levels including advanced graduate and postdoctoral trainees. ..
  13. Neurobiology of a Simple Oculomotor System: Circuitry
    NICHOLAS STRAUSFELD; Fiscal Year: 2008
    ..It will also lead to the implementation of silicon-based circuits that enable motion detection and shape discrimination and potentially provide the basis for a visual prosthetic device. [unreadable] [unreadable]..
  14. CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attention
    Leslie Kay; Fiscal Year: 2008
    ..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
  15. Conference: Progress and Issues in Olfactory Development
    Lynne Oland; Fiscal Year: 2002
    ..Several delegates whose primary research areas lie in other sensory systems but whose interests lie in related developmental questions also will be invited. ..
  16. Spatial aspects of coding in piriform cortex
    KURT ILLIG; Fiscal Year: 2007
    ..abstract_text> ..
  17. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2005
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  18. Senselab: Integration of Multidisciplinary Sensory Data
    Gordon Shepherd; Fiscal Year: 2008
    ..abstract_text> ..
  19. Integrative mechanisms of cortical circuits
    GORDON MURRAY SHEPHERD; Fiscal Year: 2010
    ..The results will therefore suggest new principles for the functioning of cortical modules, and for the neural basis of normal odor processing. ..
  20. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2001
    ....
  21. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2004
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  22. Dendodendritic computation in the olfactory glomerulus
    THOMAS CLELAND; Fiscal Year: 2004
    ..abstract_text> ..
  23. Computational mechanisms in the olfactory bulb
    THOMAS CLELAND; Fiscal Year: 2008
    ..Quantitative, integrative results such as these are unlikely to be achieved without the use of computational modeling. ..
  24. NEURAL PROCESSES IN OLFACTORY CODING
    Michael Leon; Fiscal Year: 2007
    ..We plan to use this informatics approach to extract novel hypotheses regarding the relationships between odorants, glomerular activity and odor perception. ..
  25. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
    ..These studies will lead to an understanding of the complex factors that guide GnRH neurons to their proper destinations in the hypothalamus to control the hypothalamic-pituitary-gonadal axis. ..
  26. Interactions Between Nicotine Addiction and Food Reward
    DANA SMALL; Fiscal Year: 2006
    ..If brain response does predict weight gain then we will have developed a method to identify individuals at risk for relapse so that they can be targeted for further therapeutic intervention. [unreadable] [unreadable] [unreadable]..
  27. Functional Recovery of Sensory Input to Olfactory Bulb
    DALE WACHOWIAK; Fiscal Year: 2009
    ..This work could potentially yield insight into treatment strategies for these and other syndromes related to inappropriate neuronal connections. ..
  28. Models of Sensory Coding
    Michael Leon; Fiscal Year: 2008
    ..These experiments should help us understand the mechanism by which the olfactory nervous system codes complex stimuli. ..
  29. Neurobiology of Social Attraction and Preference
    Aras Petrulis; Fiscal Year: 2009
    ..This data will provide novel insights into how sexual attraction and preference is generated by the nervous system and how sensory and internal state cues interact to regulate motivated behavior. ..
  30. BEHAVIORAL ANALYSIS OF OMPS ROLE IN ODOR PROCESSING
    STEVEN YOUNGENTOB; Fiscal Year: 2003
    ..e., at the transduction level) and may provide insight into a therapeutic strategy that has implications for a variety of neurological disorders. ..
  31. DEVELOPING A RAPID SCREEN TO DETECT OLFACTORY MUTANTS
    STEVEN YOUNGENTOB; Fiscal Year: 2001
    ..For each phase, we will provide detailed information via a Web-based database linked to centralized resources. ..
  32. EARLY EXPERIENCE AND NEURODEGENERATION
    Michael Leon; Fiscal Year: 2002
    ..Additional experiments will test the hypothesis that a reduction in cell death during enhanced early olfactory experience occurs during a mechanism mediated by the Bcl-2 protein family. ..
  33. Distribution and Role of CaMKII in Mouse Olfactory Bulb
    Dong Jing Zou; Fiscal Year: 2003
    ..In particular, we will investigate whether CaMKII activity regulates the development of granule cells, the most abundant neurons in the olfactory bulb. ..
  34. In utero ethanol experience and olfactory plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..It will also establish a chemosensory related conceptual framework of fetal exposure with broad based importance in child development and drug abuse. ..
  35. Neural substrates of taste, smell and flavor in humans
    DANA SMALL; Fiscal Year: 2006
    ..g., Alzheimer's disease) or patients who may respond abnormally to food stimuli (e.g., bulimia). This research will also provide important information into the nature of polymodal sensory integration. [unreadable] [unreadable]..
  36. Neuroinformatic Analysis of Olfactory Coding
    Michael Leon; Fiscal Year: 2006
    ..The combination of these approaches should help resolve the differences between the conflicting models of olfactory coding. ..
  37. Cognitive and affective influences on taste processing
    Dana M Small; Fiscal Year: 2010
    ..This research will provide fundamental information about human gustation and it will provide important baseline data for future studies of gustatory processing in the obese and individuals with an eating, drug or alcohol disorder. ..
  38. Interaction of ApoE with Estrogen in the Olfactory System
    Britto Nathan; Fiscal Year: 2008
    ..A better understanding of the apoE-estrogen interaction is vital to the therapeutic usefulness of estrogens in postmenopausal women. [unreadable] [unreadable] [unreadable]..
  39. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  40. Contribution of Estradiol to Female Neural Development
    Michael Baum; Fiscal Year: 2009
    ..Affirmation of a perinatal role for estradiol in brain sexual differentiation in female mice would raise the question of whether estradiol plays a similar role in female-typical psychosexual differentiation in women. ..
  41. Chemosensory Processing in Chemical Communication
    Michael Meredith; Fiscal Year: 2010
    ..The rodent amygdala uses circuits to analyze and classify chemosensory signals that have common features with circuits used by other species to analyze and classify other types of sensory stimuli. ..
  42. MECHANISMS OF OLFACTORY TRANSDUCTION
    Barry W Ache; Fiscal Year: 2010
    ..abstract_text> ..
  43. fMRI of the Mesolimbic Dopamine System in Risky Drinkers
    David Kareken; Fiscal Year: 2008
    ..The work will advance our understanding of how brain function in key regions is associated with one or both of two main risk factors for alcoholism. ..
  44. Phosphoinositide Signaling in Mammalian Olfaction
    BARRY ACHE; Fiscal Year: 2003
    ..This new, exciting line of investigation should have high impact on the field, making it competitive for R01 funding once the proposed additional preliminary data are in hand. ..
  45. ODOR PROCESSING AND OLFACTORY BULB LOCAL CIRCUITS
    JOHN KAUER; Fiscal Year: 2004
    ..abstract_text> ..
  46. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  47. Development of the Main Olfactory System
    Peter Mombaerts; Fiscal Year: 2006
    ..abstract_text> ..
  48. SPATIAL ORGANIZATION OF THE OLFACTORY SYSTEM
    Thomas Schoenfeld; Fiscal Year: 2002
    ..and the extent to which rhinotopy guides the functioning, development and persistent renewal of the primary olfactory pathways. The findings should help to identify important strategies for studying the role of spatial coding in the ..
  49. The accessory olfactory system in mice
    Peter Mombaerts; Fiscal Year: 2007
    ..The results will provide new insights into the biology of pheromone communication in mammals. ..
  50. Plasticity in Mouse Olfactory System
    Peter Mombaerts; Fiscal Year: 2007
    ..As the brain must be wired properly in order to function properly, the proposed studies will thus be relevant for understanding and treating neurological and psychiatric disorders. [unreadable] [unreadable]..
  51. Oscillation and Temporal Encoding of Olfactory Info
    Gilles Laurent; Fiscal Year: 2007
    ..This work will thus have relevance to present efforts to decipher memory circuits in rodents and primates and coding strategies used by the human brain. [unreadable] [unreadable]..
  52. Regulation of mammalian odorant receptor gene expression
    Peter Mombaerts; Fiscal Year: 2008
    ..As mammalian brain function relies on a great many neuronal cell types, this research will contribute to our understanding of neural development and function. ..
  53. Unconventional receptor neurons in nasal epithelia
    ANNELOTTE HANSEN; Fiscal Year: 2008
    ..abstract_text> ..
  54. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2008
    ....
  55. DEVELOPMENT OF THE GUSTATORY SYSTEM
    RICHARD NORTHCUTT; Fiscal Year: 2005
    ..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
  56. DIFFERENTIATION OF SEXUAL BEHAVIOR
    Michael Baum; Fiscal Year: 2005
    ..abstract_text> ..
  57. Zeiss LSM 510 Laser Scanning Microscope
    JOHN RASH; Fiscal Year: 2002
    ..The DIC Board of Directors will meet bi-monthly to insure continued efficient scheduling and operation of the replacement confocal microscope, to consider future upgrades, and to establish or change DIC access policies. ..
  58. Signal transduction in the vomeronasal organ
    JESSICA BRANN; Fiscal Year: 2005
    ..In addition, I will examine the role of the protein-protein interaction between the two types of ion channels in the propagation of the odor response. ..