Genomes and Genes
Summary: Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. It includes the OLFACTORY NERVE; OLFACTORY BULB; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex. The term rhinencephalon is restricted to structures in the CNS receiving fibers from the olfactory bulb.
Publications303 found, 100 shown here
- Olfaction: diverse species, conserved principlesBarry W Ache
Whitney Lab for Marine Bioscience, Department of Zoology, Center for Smell and Taste and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
Neuron 48:417-30. 2005..These common features span a phylogenetically broad array of animals, implying that there is an optimal solution to the problem of detecting and discriminating odors...
- Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfactionMattias C Larsson
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Neuron 43:703-14. 2004..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
- Molecular, anatomical, and functional organization of the Drosophila olfactory systemAfrica Couto
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
Curr Biol 15:1535-47. 2005..A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at single-cell resolution...
- Speed and accuracy of olfactory discrimination in the ratNaoshige Uchida
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nat Neurosci 6:1224-9. 2003....
- Representations of odor in the piriform cortexDan D Stettler
Department of Neuroscience and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neuron 63:854-64. 2009..This representation suggests organizational principles that differ from those in neocortical sensory areas where cells responsive to similar stimulus features are clustered and response properties vary smoothly across the cortex...
- Divisive normalization in olfactory population codesShawn R Olsen
Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA
Neuron 66:287-99. 2010....
- Receptors and neurons for fly odors in DrosophilaWynand Van der Goes van Naters
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
Curr Biol 17:606-12. 2007..We propose a model describing how these receptors might be used by a male to distinguish suitable from unsuitable mating partners through a simple logic...
- Cellular-resolution population imaging reveals robust sparse coding in the Drosophila mushroom bodyKyle S Honegger
Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Neurosci 31:11772-85. 2011..Our results indicate that the fundamental feature of odor processing in the MB is to create sparse stimulus representations in a format that facilitates arbitrary associations between odor and punishment or reward...
- Neuronal filtering of multiplexed odour representationsFrancisca Blumhagen
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Nature 479:493-8. 2011..These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes...
- Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillationsCindy Poo
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 62:850-61. 2009..Together, our results reveal that global inhibition and oscillations are major synaptic mechanisms shaping odor representations in olfactory cortex...
- Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortexKei M Igarashi
Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
J Neurosci 32:7970-85. 2012..Surprisingly, in anterior OC areas, the two cell types projected to segregated subareas. These results suggest that MCs and TCs transmit temporally distinct odor information to different OC targets...
- Functional analysis of a higher olfactory center, the lateral hornNitin Gupta
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 32:8138-48. 2012..Our results rather point to three other possible roles of LHNs: extracting general stimulus features such as odor intensity; mediating bilateral integration of sensory information; and integrating multimodal sensory stimuli...
- Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafishYuki Sato
Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
J Neurosci 25:4889-97. 2005....
- Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulbKevin M Cury
Department of Molecular and Cellular Biology, Harvard University, Center for Brain Science, 16 Divinity Avenue, Cambridge, MA 02138, USA
Neuron 68:570-85. 2010..These results suggest that inhalation-coupled transient activity forms a robust neural code that is invariant to changes in respiration behavior...
- How is the olfactory map formed and interpreted in the mammalian brain?Kensaku Mori
Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
Annu Rev Neurosci 34:467-99. 2011....
- Naris occlusion alters the electro-olfactogram: evidence for compensatory plasticity in the olfactory systemChristopher T Waggener
Department of Biology, Randolph Macon College, Ashland, VA 23005, USA
Neurosci Lett 427:112-6. 2007..These results provide the most direct support, to date, for compensatory plasticity in the olfactory system...
- Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromonesFuqiang Xu
Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA
J Comp Neurol 489:491-500. 2005..fMRI results demonstrate that both the main and the accessory olfactory systems may respond to volatile compounds but with different selectivity, suggesting a greater integration of the two olfactory pathways than traditionally believed.
- Lateral presynaptic inhibition mediates gain control in an olfactory circuitShawn R Olsen
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 452:956-60. 2008..A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal...
- Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitryL B Haberly
Department of Anatomy and Neuroscience Program, University of Wisconsin, Madison, WI 53706, USA
Chem Senses 26:551-76. 2001....
- Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulbRyan M Carey
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
J Neurosci 31:10615-26. 2011....
- A novel multigene family may encode odorant receptors: a molecular basis for odor recognitionL Buck
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Cell 65:175-87. 1991..The members of this novel gene family are likely to encode a diverse family of odorant receptors...
- Cortical processing of odor objectsDonald A Wilson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neuron 72:506-19. 2011..Recent findings regarding the neural architecture, physiology, and plasticity of the olfactory cortex, principally the piriform cortex, will be described in the context of how this paleocortical structure creates odor objects...
- Axonal wiring in the mouse olfactory systemPeter Mombaerts
Rockefeller University, New York, New York 10021, USA
Annu Rev Cell Dev Biol 22:713-37. 2006..ORs determine both the odorant response profile of the OSN and the projection of its axon to a specific glomerulus. I focus on genetic approaches to the axonal wiring problem, particularly on how ORs may function in axonal wiring...
- The accessory olfactory bulb in the adult rat: a cytological study of its cell types, neuropil, neuronal modules, and interactions with the main olfactory systemJorge Larriva-Sahd
Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Queretaro, CP 76001 Qro, Mexico
J Comp Neurol 510:309-50. 2008..Because IGCs are a well-known source of modulatory inputs to LPCs, both MACs and INBs represent a site of convergence of the MOB with the AOB...
- Odor representations in olfactory cortex: distributed rate coding and decorrelated population activityKeiji Miura
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Neuron 74:1087-98. 2012..These findings demonstrate profound transformations in the dynamics of odor representations from the olfactory bulb to cortex and reveal likely substrates for odor-guided decisions...
- A presynaptic gain control mechanism fine-tunes olfactory behaviorCory M Root
Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 59:311-21. 2008..These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs...
- Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neuronsJohn P McGann
Department of Biology, Boston University, Boston, Massachusetts 02215, USA
Neuron 48:1039-53. 2005..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity...
- Intrinsic membrane properties and inhibitory synaptic input of kenyon cells as mechanisms for sparse coding?Heike Demmer
University of Cologne, Institute of Zoology and Physiology, Center for Molecular Medicine Cologne, CECAD, Weyertal 119, 50931 Cologne, Germany
J Neurophysiol 102:1538-50. 2009....
- Asymmetric neurotransmitter release enables rapid odour lateralization in DrosophilaQuentin Gaudry
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 493:424-8. 2013..Our data also show that small differences in spike timing and spike rate can produce reliable differences in olfactory behaviour...
- Organization of deutocerebral neuropils and olfactory behavior in the centipede Scutigera coleoptrata (Linnaeus, 1758) (Myriapoda: Chilopoda)Andy Sombke
Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll Straße 8, 07745 Jena, Germany
Chem Senses 36:43-61. 2011..These results are in line with the morphological findings concerning the well-developed olfactory centers in the deutocerebrum of this species...
- Pre-target axon sorting establishes the neural map topographyTakeshi Imai
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113 0032, Japan
Science 325:585-90. 2009..Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons...
- Parallel olfactory systems in insects: anatomy and functionC Giovanni Galizia
University of Konstanz, Konstanz, Germany
Annu Rev Entomol 55:399-420. 2010..In this paper, we review the situation across insect species and offer hypotheses for the function and evolution of parallel olfactory systems...
- Representation of odorants by receptor neuron input to the mouse olfactory bulbM Wachowiak
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
Neuron 32:723-35. 2001..Finally, odorant activation slopes could differ across glomeruli, and for different odorants activating the same glomerulus. These results imply a high degree of complexity in odorant representations at the level of olfactory bulb input...
- Olfactory coding with patterns of response latenciesStephan Junek
Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Neuron 67:872-84. 2010..Our results suggest that the latency patterns of M/T cells contain all the information higher brain centers need to identify odors and their concentrations...
- The neurobiology of insect olfaction: sensory processing in a comparative contextJOSHUA P MARTIN
Department of Neuroscience, College of Science, University of Arizona, 1040 East Fourth Street, Tucson, AZ 85721 0077, USA
Prog Neurobiol 95:427-47. 2011..We propose that this perspective is beneficial for insect olfactory neurobiology in particular and sensory neurobiology in general...
- Olfactory representations by Drosophila mushroom body neuronsGlenn C Turner
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
J Neurophysiol 99:734-46. 2008..By comparing activity patterns evoked by the same odors across olfactory receptor neurons and across KCs, we show that representations of different odors do indeed become less correlated as they progress through the olfactory system...
- Precise olfactory responses tile the sniff cycleRoman Shusterman
Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
Nat Neurosci 14:1039-44. 2011..The temporal specificity of mitral/tufted cell output provides a potentially rich source of information for downstream olfactory areas...
- Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discriminationAlexander Fleischmann
Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neuron 60:1068-81. 2008..The M71 transgenic mice readily detect other odors in the presence of acetophenone. These observations have implications for how receptor activation in the periphery is represented in the brain and how these representations encode odors...
- Mice deficient in G(olf) are anosmicL Belluscio
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Neuron 20:69-81. 1998..These behavioral phenotypes, taken together with the patterns of G(olf) expression, suggest that G(olf) is required for olfactory signal transduction and may also function as an essential signaling molecule more centrally in the brain...
- Olfactory perception: receptors, cells, and circuitsChih Ying Su
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Cell 139:45-59. 2009..Here, we discuss the insight that has been gained into the receptors, cells, and circuits that underlie the sense of smell...
- Odor quality coding and categorization in human posterior piriform cortexJames D Howard
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Nat Neurosci 12:932-8. 2009..These findings substantiate theoretical models emphasizing the importance of distributed piriform templates for the perceptual reconstruction of odor object quality...
- Coding and synaptic processing of sensory information in the glomerular layer of the olfactory bulbMatt Wachowiak
Department of Biology, Boston University, Boston, MA 02215, USA
Semin Cell Dev Biol 17:411-23. 2006..We speculate that odor representations and their postsynaptic processing are tuned to and shaped by the sniffing behavior of the animal...
- State-dependent sensory gating in olfactory cortexMasayoshi Murakami
Department of Physiology, Graduate School of Medicine, School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Neuron 46:285-96. 2005..They suggest a state-dependent switchover of signal processing modes in the olfactory cortex...
- New insights into an ancient insect nose: the olfactory pathway of Lepismachilis y-signata (Archaeognatha: Machilidae)Christine Missbach
Max Planck Institute for Chemical Ecology, Department of Neuroethology, Hans Knoll Strasse 8, D 07745 Jena, Germany
Arthropod Struct Dev 40:317-33. 2011..The connection of the glomerular neuropils to higher brain centers remains unclear and mushroom bodies are absent as reported from other archaeognathan species. We discuss the evolutionary implications of these findings...
- Postnatal refinement of peripheral olfactory projectionsDong Jing Zou
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Science 304:1976-9. 2004..Persistence may be due, in part, to prolonged survival of olfactory sensory neurons...
- Trigeminal collaterals in the nasal epithelium and olfactory bulb: a potential route for direct modulation of olfactory information by trigeminal stimuliMichele L Schaefer
Department of Cellular and Structural Biology and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Comp Neurol 444:221-6. 2002..Furthermore, the collateral innervation of the epithelium and bulb may provide an avenue whereby nasal irritants could affect processing of coincident olfactory stimuli...
- From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafishNobuhiko Miyasaka
Laboratories for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Neurosci 29:4756-67. 2009..Moreover, our finding of asymmetric bulbo-habenular projection renders the olfactory system an attractive model for the studies of brain asymmetry and lateralized behaviors...
- Mushroom body memoir: from maps to modelsMartin Heisenberg
Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
Nat Rev Neurosci 4:266-75. 2003
- Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafishTetsuya Koide
Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Proc Natl Acad Sci U S A 106:9884-9. 2009..Thus, the integrated approach combining genetic, neuroanatomical, and behavioral methods enables us to elucidate the neural circuit mechanism underlying various olfactory behaviors in adult zebrafish...
- Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineageElise Cau
IGBMC, 1 rue Laurent Fries, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 129:1871-80. 2002..These results illustrate the versatility of neural bHLH genes which adopt either a determination or a differentiation function, depending primarily on the timing of their expression in neural progenitors...
- Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal/ventral positioning of glomeruli in the olfactory bulbKazunari Miyamichi
Core Research for Evolutional Science and Technology, The University of Tokyo, Tokyo 113 0032, Japan
J Neurosci 25:3586-92. 2005..The present study indicates that the OR gene choice may be more restricted by the OSN location in the OE than what has been thought...
- Neural map formation in the mouse olfactory systemHitoshi Sakano
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
Neuron 67:530-42. 2010..Here, we review the recent progress on the study of olfactory map formation in rodents. We will discuss how neuronal identity is represented at axon termini and how the OR-instructed axonal projection is regulated...
- Target neuron prespecification in the olfactory map of DrosophilaG S Jefferis
Neurosciences Program, Department of Biological Sciences, Stanford University, CA 94305, USA
Nature 414:204-8. 2001..These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity...
- Serotonergic modulation of odor input to the mammalian olfactory bulbGabor C Petzold
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
Nat Neurosci 12:784-91. 2009..Our data indicate that the serotonergic system regulates odor inputs in the olfactory bulb and suggest that behavioral states may alter odor processing at the earliest stages...
- Subsystem organization of the mammalian sense of smellSteven D Munger
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Annu Rev Physiol 71:115-40. 2009..An integrative approach that includes gene targeting methods, optical and electrophysiological recording, and behavioral analysis has helped to elucidate the functional significance of this subsystem organization for the sense of smell...
- The coding of odour-intensity in the honeybee antennal lobe: local computation optimizes odour representationSilke Sachse
Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Str 28 30, 14195 Berlin, Germany
Eur J Neurosci 18:2119-32. 2003....
- Odorant receptors govern the formation of a precise topographic mapF Wang
Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Cell 93:47-60. 1998..These data, along with additional receptor substitutions, indicate that the odorant receptor plays an instructive role in the establishment of the topographic map...
- Function and morphology of the antennal lobe: new developmentsB S Hansson
Department of Ecology, Lund University, Sweden
Annu Rev Entomol 45:203-31. 2000....
- Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory mapWeizhe Hong
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, California, USA
Nat Neurosci 12:1542-50. 2009..The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation...
- Molecular detection of pheromone signals in mammals: from genes to behaviourCatherine Dulac
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
Nat Rev Neurosci 4:551-62. 2003
- Temporally diverse firing patterns in olfactory receptor neurons underlie spatiotemporal neural codes for odorsBaranidharan Raman
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:1994-2006. 2010..Thus, our results demonstrate the origin and subsequent reformatting of spatiotemporal neural codes for odors...
- The olfactory granule cell: from classical enigma to central role in olfactory processingGordon M Shepherd
Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Brain Res Rev 55:373-82. 2007..Among other important properties, granule cells undergo neurogenesis from precursor cells throughout adult life. This originally enigmatic cell thus appears to play a critical role in olfactory processing...
- Characterization and coding of behaviorally significant odor mixturesJeffrey A Riffell
University of Arizona, Tucson, 85721, USA
Curr Biol 19:335-40. 2009....
- A map of olfactory representation in the Drosophila mushroom bodyHui Hao Lin
Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan, ROC
Cell 128:1205-17. 2007..Our data suggest that olfactory coding at the AL is decoded in the MB and then transferred via distinct lobes to separate higher brain centers...
- Precision and diversity in an odor map on the olfactory bulbEdward R Soucy
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, Massachusetts 02138, USA
Nat Neurosci 12:210-20. 2009..This local diversity of sensory tuning stands in marked distinction from other brain maps. Given the reliable placement of the glomeruli, it represents a feature, not a flaw, of the olfactory bulb...
- Development of the Drosophila olfactory systemVeronica Rodrigues
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
Adv Exp Med Biol 628:82-101. 2008....
- Behavioral state regulation of dendrodendritic synaptic inhibition in the olfactory bulbYusuke Tsuno
Department of Physiology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
J Neurosci 28:9227-38. 2008..These results provide evidence that behavioral state-dependent global changes in cholinergic tone modulate dendrodendritic synaptic inhibition and the information processing mode in the olfactory bulb...
- High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidationMichael E Hasselmo
Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, 2 Cummington St, Boston, MA 02215, USA
Prog Brain Res 145:207-31. 2004
- Spatiotemporal representations in the olfactory systemAndreas T Schaefer
Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
Trends Neurosci 30:92-100. 2007..Based on such evidence, we have devised a working model to assess further the relevance of such spatiotemporal processes in odour representation...
- Testing odor response stereotypy in the Drosophila mushroom bodyMala Murthy
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 59:1009-23. 2008....
- Mesenchymal/epithelial induction mediates olfactory pathway formationA S LaMantia
Department of Cell and Molecular Physiology and Center for Neuroscience, The University of North Carolina at Chapel Hill, Medical School, 27599, USA
Neuron 28:411-25. 2000..Thus, a cellular and molecular mechanism that facilitates musculoskeletal and vascular development elsewhere in the embryo has been adapted to guide the differentiation of the olfactory pathway in the developing forebrain...
- Olfactory inputs to hypothalamic neurons controlling reproduction and fertilityHayan Yoon
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Cell 123:669-82. 2005..Further visualization of afferents to LHRH neurons across the brain offers a unique opportunity to uncover complex polysynaptic circuits modulating reproduction and fertility...
- Olfactory conditioning of proboscis activity in Drosophila melanogasterMarie Ange Chabaud
Developpement, Evolution et Plasticité du Système Nerveux, CNRS, Bat 32 33, Avenue de la Terrasse, 91198, Gif sur Yvette Cedex, France
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:1335-48. 2006..We also showed that learning performance was dependent on food motivation, by comparing flies subjected to different starvation regimes...
- Hierarchical regulation of odorant receptor gene choice and subsequent axonal projection of olfactory sensory neurons in zebrafishYuki Sato
Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Neurosci 27:1606-15. 2007..These data demonstrate two distinct modes of OR expression and suggest a model of the hierarchical regulation of OR gene choice and subsequent axonal projection in the zebrafish olfactory system...
- Functional neuronal processing of body odors differs from that of similar common odorsJohan N Lundstrom
Department of Psychology, McGill University, Montreal, QC, H3A1B1, Canada
Cereb Cortex 18:1466-74. 2008..The results provide evidence that social olfactory stimuli of high ecological relevance are processed by specialized neuronal networks similar to what has previously been demonstrated for auditory and visual stimuli...
- Differential neural responses evoked by orthonasal versus retronasal odorant perception in humansDana M Small
The John B Pierce Laboratory, New Haven, Connecticut 06519, USA
Neuron 47:593-605. 2005..These findings demonstrate differential neural recruitment depending upon the route of odorant administration and suggest that its effect is influenced by whether an odorant represents a food...
- Behavioral consequences of innate preferences and olfactory learning in hawkmoth-flower interactionsJeffrey A Riffell
Division of Neurobiology and Center for Insect Science, Arizona Research Laboratories, and Departments of Chemistry and Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 105:3404-9. 2008..Behavioral flexibility and the olfactory contrast between flowers permit the hawkmoths to persist within a dynamic environment, while at the same time to function as the major pollinator of one plant species...
- Genetic analysis of brain circuits underlying pheromone signalingC Dulac
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Genet 40:449-67. 2006..We will review and discuss the specific contribution of each of the two chemosensory systems that ensure specific behavioral responses to conspecific animals...
- Morphological and functional plasticity of olfactory ensheathing cellsAdele J Vincent
NeuroRepair Group, Discipline of Anatomy and Physiology, University of Tasmania Hobart, Private Bag 24, Tasmania, Australia 7001
J Neurocytol 34:65-80. 2005..Finally, we will explore the possibility that recent microarray data could point to OECs assuming an innate immune function or playing a role in modulating neuroinflammation...
- Histological and ultrastructural characteristics of the primordial vomeronasal organ in lungfishShoko Nakamuta
Laboratory of Veterinary Anatomy, Faculty of Agriculture, Iwate University, Morioka, Iwate 020 8550, Japan
Anat Rec (Hoboken) 295:481-91. 2012..This study may provide important clues to elucidate how the vomeronasal organ emerged during the evolution of vertebrates...
- Distribution and functional organization of glomeruli in the olfactory bulbs of zebrafish (Danio rerio)Oliver R Braubach
Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
J Comp Neurol 520:2317-39, Spc1. 2012..Collectively, our results provide a uniquely detailed description of a vertebrate olfactory system and highlight anatomically distinct parallel neural pathways that mediate early aspects of olfactory processing in the zebrafish...
- Parallel processing via a dual olfactory pathway in the honeybeeMartin F Brill
Department of Behavioral Physiology and Sociobiology, Biozentrum, University of Wurzburg, 97074 Wurzburg, Germany
J Neurosci 33:2443-56. 2013....
- Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortexHyun H Kim
Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 26:9548-59. 2006..In summary, the present study provides an initial characterization of the molecular mechanisms associated with odor stimulation on second order neuronal plasticity and phenotype in the olfactory system...
- Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in miceDiego Restrepo
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Horm Behav 46:247-56. 2004..In each case, one system or the other (or both) participates in a specific behavioral or hormonal response...
- Brain architecture in the terrestrial hermit crab Coenobita clypeatus (Anomura, Coenobitidae), a crustacean with a good aerial sense of smellSteffen Harzsch
Max Planck Institute for Chemical Ecology, Department of Evolutionary Neuroethology, Beutenberg Campus, Hans Knöll Str, 8, D 07745 Jena, Germany
BMC Neurosci 9:58. 2008....
- Expanded endoscopic endonasal resection of an olfactory schwannomaHilal A Kanaan
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg Pediatr 2:261-5. 2008....
- Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variabilityAnna Brochtrup
Institut fur Neurobiologie, Universitat Munster, Badestr 9, D 48149 Munster, Germany
Curr Opin Neurobiol 21:85-92. 2011..Recent findings revealed an astonishing morphological diversity among members of the same interneuron class, suggesting an unexpected variability in local microcircuits involved in insect sensory processing...
- Centrifugal innervation of the mammalian olfactory bulbShinji Matsutani
Department of Functional Morphology, Kitasato University School of Nursing, Kanagawa, Japan
Anat Sci Int 83:218-27. 2008....
- Solitary olfactory groove schwannomaGiuseppe Mirone
Neurosurgery, Department of Neurological Sciences, c o Ospedale CTO, Second University of Naples, Viale Colli Aminei 21, 80131 Naples, Italy
J Clin Neurosci 16:454-6. 2009..We briefly review the pertinent literature, stress the distinctive clinical and neuroradiological findings and discuss the surgical planning and theories about the pathogenesis of schwannomas in this unusual location...
- Local interneuron diversity in the primary olfactory center of the moth Manduca sextaCarolina E Reisenman
Department of Neuroscience, University of Arizona, Tucson, 85721, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 197:653-65. 2011..These results show that, as observed in other insects, LNs are diverse, which likely determines the complexity of the inhibitory network that regulates AL output...
- Chemotopic odorant coding in a mammalian olfactory systemBrett A Johnson
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
J Comp Neurol 503:1-34. 2007..A critical analysis suggests that alternative coding mechanisms for odor quality, such as those based on temporal patterns of responses, enjoy little experimental support...
- Dynamical encoding by networks of competing neuron groups: winnerless competitionM Rabinovich
Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093-0402, USA
Phys Rev Lett 87:068102. 2001..e., much larger than that of most traditional network structures. We show that a small winnerless competition network composed of FitzHugh-Nagumo spiking neurons efficiently transforms input information into a spatiotemporal output...
- The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouseSonoko Hasegawa
KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka, 565 0871, Japan
Mol Cell Neurosci 38:66-79. 2008..Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb...
- Dissociable codes of odor quality and odorant structure in human piriform cortexJay A Gottfried
Cognitive Neurology and Alzheimer s Disease Center, Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, Illinois 60611, USA
Neuron 49:467-79. 2006..In turn, quality-based codes are independent of any simple structural configuration, implying that synthetic mechanisms may underlie our experience of smell...
- Insect olfaction: receptors, signal transduction, and behaviorK Sato
Department of Integrated Biosciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba, 277 8562, Japan
Results Probl Cell Differ 47:121-38. 2009..The understanding of the molecular mechanism of insect olfaction will help in the development of insect repellents for controlling insect pest and vector populations for a wide range of pathogens...
- Olfactory perceptual stability and discriminationDylan C Barnes
Neurobehavioral Institute, Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, Oklahoma 73019, USA
Nat Neurosci 11:1378-80. 2008..This piriform cortical ensemble activity predicts olfactory perception...
- Olfactory modulation of flight in Drosophila is sensitive, selective and rapidVikas Bhandawat
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
J Exp Biol 213:3625-35. 2010..This makes these behaviors a useful paradigm for studying the relationship between sensory neuron activity and behavioral decision-making in a simple and genetically tractable organism...
- Encoding a temporally structured stimulus with a temporally structured neural representationStacey L Brown
National Institute of Child Health and Human Development, US National Institutes of Health, Building 35, Room 3A 102, Bethesda, Maryland 20892, USA
Nat Neurosci 8:1568-76. 2005..Thus, ensemble-based spatiotemporal coding could disambiguate complex and potentially confounding temporally structured sensory stimuli and thereby provide an invariant response to a stimulus presented in various ways...
- Functional neuroimaging of odor imageryJ Djordjevic
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Neuroimage 24:791-801. 2005..Overall, the findings indicated that neural networks engaged during odor perception and imagery overlap partially...
- Associative conditioning tunes transient dynamics of early olfactory processingPatricia C Fernandez
Arizona State University, School of Life Sciences, Tempe, AZ 85287 4501, USA
J Neurosci 29:10191-202. 2009..AL activity was modified by conditioning to improve separation of odor representations. These data suggest that one role of reinforcement is to "tune" the AL such that relevant odors become more discriminable...
- Aversive learning enhances perceptual and cortical discrimination of indiscriminable odor cuesWen Li
Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Science 319:1842-5. 2008..That completely indiscriminable sensations can be transformed into discriminable percepts further accentuates the potency of associative learning to enhance sensory cue perception and support adaptive behavior...
- Anterior Olfactory NucleusPeter C Brunjes; Fiscal Year: 2013..described in the present proposal is designed to examine carefully a very important region in the central olfactory pathways. The anterior olfactory nucleus (AON) has synaptic connections at nearly every point of information ..
- EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE & PARKINSONISMRICHARD DOTY; Fiscal Year: 1991..visual, somatosensory, and motor pathways, significant numbers of neurofibrillary tangles are found in the olfactory pathways of AD brains, particularly regions receiving direct projections from the olfactory bulb, including the uncus ..
- Role of Arrestin in Olfactory DesensitizationCATHERINE MERRILL; Fiscal Year: 2003..such as odorant receptors), these studies will initially investigate the role of arrestin genes in olfactory pathways using established mutants in the well-characterized Drosophila melanogaster model system...
- Neural Development: Intercellular and Humoral ControlRichard Levine; Fiscal Year: 2005..in olfactory receptor neuron sorting and in formation of glomerular compartments during development of olfactory pathways; (3) steroid-hormonal regulation of development of identified motor neurons in vivo and in primary cell ..
- ANATOMICAL BASIS OF OLFACTORY DISCRIMINATIONBurton Slotnick; Fiscal Year: 1980..Functions of secondary olfactory pathways in odor detection, detection threshold, intensity difference threshold and 2-odor discrimination will be ..
- Chemosensory activation of amygdala: Modulation by GnRHCAMILLE BLAKE; Fiscal Year: 2006..Chemosensory signals received during mating activate brain regions along the vomeronasal and main olfactory pathways. These activated regions contain cell bodies and fibers of gonadotropin-releasing hormone (GnRH) neurons...
- GENETIC & MOLECULAR ANALYSIS OF DROSOPHILA OLFACTIONJohn Carlson; Fiscal Year: 1993..Such mutants define genes which may play roles in chemically-specific olfactory pathways; these genes could encode olfactory receptor molecules or other products required for transduction or ..
- Ensemble coding in olfactory cortexDonald Wilson; Fiscal Year: 2006..This combination is ideally suited for the R21 mechanism. ..
- Cholinergic modulation of olfactory processingChristiane Linster; Fiscal Year: 2007..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. [unreadable] [unreadable] [unreadable]..
- CRCNS: Computational and experimental analysis of noradrenergic function in earlyChristiane Linster; Fiscal Year: 2010..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
- Cholinergic modulation of odor responsesChristiane Linster; Fiscal Year: 2003....
- Conf Proposal:Gordon Research Conf on Neuroethology 2005NICHOLAS STRAUSFELD; Fiscal Year: 2005..The conference is intended for the broad neuroethological community at all professional levels including advanced graduate and postdoctoral trainees. ..
- Neurobiology of a Simple Oculomotor System: CircuitryNICHOLAS STRAUSFELD; Fiscal Year: 2008..It will also lead to the implementation of silicon-based circuits that enable motion detection and shape discrimination and potentially provide the basis for a visual prosthetic device. [unreadable] [unreadable]..
- CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attentionLeslie Kay; Fiscal Year: 2008..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
- Conference: Progress and Issues in Olfactory DevelopmentLynne Oland; Fiscal Year: 2002..Several delegates whose primary research areas lie in other sensory systems but whose interests lie in related developmental questions also will be invited. ..
- Spatial aspects of coding in piriform cortexKURT ILLIG; Fiscal Year: 2007..abstract_text> ..
- POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTIONRICHARD DOTY; Fiscal Year: 2005..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
- Senselab: Integration of Multidisciplinary Sensory DataGordon Shepherd; Fiscal Year: 2008..abstract_text> ..
- Integrative mechanisms of cortical circuitsGORDON MURRAY SHEPHERD; Fiscal Year: 2010..The results will therefore suggest new principles for the functioning of cortical modules, and for the neural basis of normal odor processing. ..
- OLFACTION IN MULTIPLE SCLEROSISRICHARD DOTY; Fiscal Year: 2001....
- OLFACTION IN EPILEPSYRICHARD DOTY; Fiscal Year: 2004..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
- Dendodendritic computation in the olfactory glomerulusTHOMAS CLELAND; Fiscal Year: 2004..abstract_text> ..
- Computational mechanisms in the olfactory bulbTHOMAS CLELAND; Fiscal Year: 2008..Quantitative, integrative results such as these are unlikely to be achieved without the use of computational modeling. ..
- NEURAL PROCESSES IN OLFACTORY CODINGMichael Leon; Fiscal Year: 2007..We plan to use this informatics approach to extract novel hypotheses regarding the relationships between odorants, glomerular activity and odor perception. ..
- Migration of early olfactory neuronal progenitorsGERALD SCHWARTING; Fiscal Year: 2009..These studies will lead to an understanding of the complex factors that guide GnRH neurons to their proper destinations in the hypothalamus to control the hypothalamic-pituitary-gonadal axis. ..
- Interactions Between Nicotine Addiction and Food RewardDANA SMALL; Fiscal Year: 2006..If brain response does predict weight gain then we will have developed a method to identify individuals at risk for relapse so that they can be targeted for further therapeutic intervention. [unreadable] [unreadable] [unreadable]..
- Functional Recovery of Sensory Input to Olfactory BulbDALE WACHOWIAK; Fiscal Year: 2009..This work could potentially yield insight into treatment strategies for these and other syndromes related to inappropriate neuronal connections. ..
- Models of Sensory CodingMichael Leon; Fiscal Year: 2008..These experiments should help us understand the mechanism by which the olfactory nervous system codes complex stimuli. ..
- Neurobiology of Social Attraction and PreferenceAras Petrulis; Fiscal Year: 2009..This data will provide novel insights into how sexual attraction and preference is generated by the nervous system and how sensory and internal state cues interact to regulate motivated behavior. ..
- BEHAVIORAL ANALYSIS OF OMPS ROLE IN ODOR PROCESSINGSTEVEN YOUNGENTOB; Fiscal Year: 2003..e., at the transduction level) and may provide insight into a therapeutic strategy that has implications for a variety of neurological disorders. ..
- DEVELOPING A RAPID SCREEN TO DETECT OLFACTORY MUTANTSSTEVEN YOUNGENTOB; Fiscal Year: 2001..For each phase, we will provide detailed information via a Web-based database linked to centralized resources. ..
- EARLY EXPERIENCE AND NEURODEGENERATIONMichael Leon; Fiscal Year: 2002..Additional experiments will test the hypothesis that a reduction in cell death during enhanced early olfactory experience occurs during a mechanism mediated by the Bcl-2 protein family. ..
- Distribution and Role of CaMKII in Mouse Olfactory BulbDong Jing Zou; Fiscal Year: 2003..In particular, we will investigate whether CaMKII activity regulates the development of granule cells, the most abundant neurons in the olfactory bulb. ..
- In utero ethanol experience and olfactory plasticitySteven L Youngentob; Fiscal Year: 2010..It will also establish a chemosensory related conceptual framework of fetal exposure with broad based importance in child development and drug abuse. ..
- Neural substrates of taste, smell and flavor in humansDANA SMALL; Fiscal Year: 2006..g., Alzheimer's disease) or patients who may respond abnormally to food stimuli (e.g., bulimia). This research will also provide important information into the nature of polymodal sensory integration. [unreadable] [unreadable]..
- Neuroinformatic Analysis of Olfactory CodingMichael Leon; Fiscal Year: 2006..The combination of these approaches should help resolve the differences between the conflicting models of olfactory coding. ..
- Cognitive and affective influences on taste processingDana M Small; Fiscal Year: 2010..This research will provide fundamental information about human gustation and it will provide important baseline data for future studies of gustatory processing in the obese and individuals with an eating, drug or alcohol disorder. ..
- Interaction of ApoE with Estrogen in the Olfactory SystemBritto Nathan; Fiscal Year: 2008..A better understanding of the apoE-estrogen interaction is vital to the therapeutic usefulness of estrogens in postmenopausal women. [unreadable] [unreadable] [unreadable]..
- CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTIONJ Enrique Cometto Muniz; Fiscal Year: 2010..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
- Contribution of Estradiol to Female Neural DevelopmentMichael Baum; Fiscal Year: 2009..Affirmation of a perinatal role for estradiol in brain sexual differentiation in female mice would raise the question of whether estradiol plays a similar role in female-typical psychosexual differentiation in women. ..
- Chemosensory Processing in Chemical CommunicationMichael Meredith; Fiscal Year: 2010..The rodent amygdala uses circuits to analyze and classify chemosensory signals that have common features with circuits used by other species to analyze and classify other types of sensory stimuli. ..
- MECHANISMS OF OLFACTORY TRANSDUCTIONBarry W Ache; Fiscal Year: 2010..abstract_text> ..
- fMRI of the Mesolimbic Dopamine System in Risky DrinkersDavid Kareken; Fiscal Year: 2008..The work will advance our understanding of how brain function in key regions is associated with one or both of two main risk factors for alcoholism. ..
- Phosphoinositide Signaling in Mammalian OlfactionBARRY ACHE; Fiscal Year: 2003..This new, exciting line of investigation should have high impact on the field, making it competitive for R01 funding once the proposed additional preliminary data are in hand. ..
- ODOR PROCESSING AND OLFACTORY BULB LOCAL CIRCUITSJOHN KAUER; Fiscal Year: 2004..abstract_text> ..
- Molecular Boundaries For Trigeminal Chemosensory ImpactJ Cometto Muniz; Fiscal Year: 2006..abstract_text> ..
- Development of the Main Olfactory SystemPeter Mombaerts; Fiscal Year: 2006..abstract_text> ..
- SPATIAL ORGANIZATION OF THE OLFACTORY SYSTEMThomas Schoenfeld; Fiscal Year: 2002..and the extent to which rhinotopy guides the functioning, development and persistent renewal of the primary olfactory pathways. The findings should help to identify important strategies for studying the role of spatial coding in the ..
- The accessory olfactory system in micePeter Mombaerts; Fiscal Year: 2007..The results will provide new insights into the biology of pheromone communication in mammals. ..
- Plasticity in Mouse Olfactory SystemPeter Mombaerts; Fiscal Year: 2007..As the brain must be wired properly in order to function properly, the proposed studies will thus be relevant for understanding and treating neurological and psychiatric disorders. [unreadable] [unreadable]..
- Oscillation and Temporal Encoding of Olfactory InfoGilles Laurent; Fiscal Year: 2007..This work will thus have relevance to present efforts to decipher memory circuits in rodents and primates and coding strategies used by the human brain. [unreadable] [unreadable]..
- Regulation of mammalian odorant receptor gene expressionPeter Mombaerts; Fiscal Year: 2008..As mammalian brain function relies on a great many neuronal cell types, this research will contribute to our understanding of neural development and function. ..
- Unconventional receptor neurons in nasal epitheliaANNELOTTE HANSEN; Fiscal Year: 2008..abstract_text> ..
- SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGANCatherine Dulac; Fiscal Year: 2008....
- DEVELOPMENT OF THE GUSTATORY SYSTEMRICHARD NORTHCUTT; Fiscal Year: 2005..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
- DIFFERENTIATION OF SEXUAL BEHAVIORMichael Baum; Fiscal Year: 2005..abstract_text> ..
- Zeiss LSM 510 Laser Scanning MicroscopeJOHN RASH; Fiscal Year: 2002..The DIC Board of Directors will meet bi-monthly to insure continued efficient scheduling and operation of the replacement confocal microscope, to consider future upgrades, and to establish or change DIC access policies. ..
- Signal transduction in the vomeronasal organJESSICA BRANN; Fiscal Year: 2005..In addition, I will examine the role of the protein-protein interaction between the two types of ion channels in the propagation of the odor response. ..