neural pathways

Summary

Summary: Neural tracts connecting one part of the nervous system with another.

Top Publications

  1. ncbi Functional connectivity of the insula in the resting brain
    Franco Cauda
    CCS fMRI, Koelliker Hospital, Turin, Italy
    Neuroimage 55:8-23. 2011
  2. pmc Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies
    Hedy Kober
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Neuroimage 42:998-1031. 2008
  3. pmc A dual-networks architecture of top-down control
    Nico U F Dosenbach
    Washington University in St Louis School of Medicine, 4525 Scott Ave, St Louis, MO 63110, USA
    Trends Cogn Sci 12:99-105. 2008
  4. ncbi The application of graph theoretical analysis to complex networks in the brain
    Jaap C Reijneveld
    Department of Neurology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Neurophysiol 118:2317-31. 2007
  5. ncbi The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis
    Peter Fransson
    MR Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
    Neuroimage 42:1178-84. 2008
  6. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
  7. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
  8. ncbi Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
    T E J Behrens
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Oxford, UK
    Neuroimage 34:144-55. 2007
  9. pmc Toward discovery science of human brain function
    Bharat B Biswal
    Department of Radiology, New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:4734-9. 2010
  10. ncbi A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs
    Sophie Achard
    Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 26:63-72. 2006

Detail Information

Publications280 found, 100 shown here

  1. ncbi Functional connectivity of the insula in the resting brain
    Franco Cauda
    CCS fMRI, Koelliker Hospital, Turin, Italy
    Neuroimage 55:8-23. 2011
    ..These results are in agreement with connectivity studies in primates, and support the use of resting state functional analysis to investigate connectivity in the living human brain...
  2. pmc Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies
    Hedy Kober
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Neuroimage 42:998-1031. 2008
    ....
  3. pmc A dual-networks architecture of top-down control
    Nico U F Dosenbach
    Washington University in St Louis School of Medicine, 4525 Scott Ave, St Louis, MO 63110, USA
    Trends Cogn Sci 12:99-105. 2008
    ..The control systems of the brain seem to embody the principles of complex systems, encouraging resilient performance...
  4. ncbi The application of graph theoretical analysis to complex networks in the brain
    Jaap C Reijneveld
    Department of Neurology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Neurophysiol 118:2317-31. 2007
    ....
  5. ncbi The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis
    Peter Fransson
    MR Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden
    Neuroimage 42:1178-84. 2008
    ..The suggested pivotal role of the precuneus/posterior cingulate cortex in the default mode network is discussed...
  6. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
    ..They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given ..
  7. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
    ..With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior...
  8. ncbi Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
    T E J Behrens
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Oxford, UK
    Neuroimage 34:144-55. 2007
    ..We show that multi-fibre tractography offers significant advantages in sensitivity when tracking non-dominant fibre populations, but does not dramatically change tractography results for the dominant pathways...
  9. pmc Toward discovery science of human brain function
    Bharat B Biswal
    Department of Radiology, New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:4734-9. 2010
    ..To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/...
  10. ncbi A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs
    Sophie Achard
    Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 26:63-72. 2006
    ..Because the major hubs of this network are critical for cognition, its slow dynamics could provide a physiological substrate for segregated and distributed information processing...
  11. pmc Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease
    Randy L Buckner
    Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 29:1860-73. 2009
    ....
  12. ncbi Psychophysiological and modulatory interactions in neuroimaging
    K J Friston
    Wellcome Department of Cognitive Neurology, London, United Kingdom
    Neuroimage 6:218-29. 1997
    ..We focus on interactions among extrastriate, inferotemporal, and posterior parietal regions during visual processing, under different attentional and perceptual conditions...
  13. pmc Predicting human resting-state functional connectivity from structural connectivity
    C J Honey
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 106:2035-40. 2009
    ....
  14. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..Therefore, the local cortical network structure can be viewed as a skeleton of stronger connections in a sea of weaker ones. Such a skeleton is likely to play an important role in network dynamics and should be investigated further...
  15. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
    ..The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior...
  16. ncbi Whole-brain anatomical networks: does the choice of nodes matter?
    Andrew Zalesky
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia
    Neuroimage 50:970-83. 2010
    ..9 vs. sigma(4000)=53.6+/-2.2). These findings indicate that any comparison of network parameters across studies must be made with reference to the spatial scale of the nodal parcellation...
  17. pmc Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
    Alexxai V Kravitz
    Gladstone Institute of Neurological Disease, 1650 Owens St, San Francisco, California 94158, USA
    Nature 466:622-6. 2010
    ....
  18. ncbi Disrupted small-world networks in schizophrenia
    Yong Liu
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    Brain 131:945-61. 2008
    ..Detection and estimation of these alterations could prove helpful for understanding the pathophysiological mechanism as well as for evaluation of the severity of schizophrenia...
  19. pmc Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography
    Gaolang Gong
    Department of Biomedical Engineering, 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada
    Cereb Cortex 19:524-36. 2009
    ..Our results are compatible with previous structural and functional brain networks studies and provide insight into the organizational principles of human brain anatomical networks that underlie functional states...
  20. pmc Hierarchical organization of human cortical networks in health and schizophrenia
    Danielle S Bassett
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:9239-48. 2008
    ....
  21. ncbi Neuronal circuits of the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
    Annu Rev Neurosci 27:419-51. 2004
    ....
  22. ncbi Functional and effective connectivity: a review
    Karl J Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom
    Brain Connect 1:13-36. 2011
    ..I accepted the invitation to write this review with great pleasure and hope to celebrate and critique the achievements to date, while addressing the challenges ahead...
  23. ncbi Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
    T E J Behrens
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 6:750-7. 2003
    ..Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter...
  24. pmc Functional connectivity and brain networks in schizophrenia
    Mary Ellen Lynall
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 30:9477-87. 2010
    ....
  25. pmc Functional brain networks develop from a "local to distributed" organization
    Damien A Fair
    Behavioral Neuroscience Department, Oregon Health and Science University, Portland, OR, USA
    PLoS Comput Biol 5:e1000381. 2009
    ..These observations suggest that early school age children and adults both have relatively efficient systems that may solve similar information processing problems in divergent ways...
  26. ncbi Small-world networks and functional connectivity in Alzheimer's disease
    C J Stam
    Department of Clinical Neurophysiology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Cereb Cortex 17:92-9. 2007
    ..Graph theoretical analysis may be a useful approach to study the complexity of patterns of interrelations between EEG channels...
  27. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits...
  28. pmc Neurodegenerative diseases target large-scale human brain networks
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:42-52. 2009
    ..Future studies may clarify how these complex systems are assembled during development and undermined by disease...
  29. ncbi Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies
    Andreas Weissenbacher
    MR Centre of Excellence, Medical University of Vienna, Vienna, Austria
    Neuroimage 47:1408-16. 2009
    ....
  30. pmc The global signal and observed anticorrelated resting state brain networks
    Michael D Fox
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Neurophysiol 101:3270-83. 2009
    ....
  31. pmc Reproducibility of quantitative tractography methods applied to cerebral white matter
    Setsu Wakana
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD 21205, USA
    Neuroimage 36:630-44. 2007
    ..Hemispheric asymmetry was observed for the size of white matter tracts projecting to the temporal lobe. This protocol provides guidelines for reproducible DTI-based tract-specific quantification...
  32. ncbi A diffusion tensor imaging tractography atlas for virtual in vivo dissections
    Marco Catani
    Institute of Psychiatry, King s College London, London, UK
    Cortex 44:1105-32. 2008
    ..The template can be used for single case studies and case-control comparisons. An atlas of the 3D reconstructions of the single tracts is also provided as anatomical reference in the Montreal Neurological Institute (MNI) space...
  33. pmc Identification and classification of hubs in brain networks
    Olaf Sporns
    Department of Psychological and Brain Sciences and Program in Cognitive Science, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 2:e1049. 2007
    ....
  34. ncbi The small world of the cerebral cortex
    Olaf Sporns
    Department of Psychology, Indiana University, Bloomington 47405, USA
    Neuroinformatics 2:145-62. 2004
    ..We discuss the significance of these universal organizational features of cortex in light of functional brain anatomy. Supplementary materials are at www.indiana.edu/~cortex/lab.htm...
  35. ncbi Efficiency of functional brain networks and intellectual performance
    Martijn P van den Heuvel
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Neurosci 29:7619-24. 2009
    ..Our findings indicate a strong positive association between the global efficiency of functional brain networks and intellectual performance...
  36. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
    ..Our experiments reveal high specificity in the subcellular organization of excitatory circuits...
  37. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
    ..Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution...
  38. pmc Network analysis of intrinsic functional brain connectivity in Alzheimer's disease
    Kaustubh Supekar
    Graduate Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, California, USA
    PLoS Comput Biol 4:e1000100. 2008
    ..Small-world metrics can characterize the functional organization of the brain in AD, and our findings further suggest that these network measures may be useful as an imaging-based biomarker to distinguish AD from healthy aging...
  39. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
    ..The map of the whole cortical circuit shows that there are very few "strong" but many "weak" excitatory projections, each of which may involve only a few percentage of the total complement of excitatory synapses of a single neuron...
  40. pmc Ventral and dorsal pathways for language
    Dorothee Saur
    Department of Neurology, University Medical Center Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Proc Natl Acad Sci U S A 105:18035-40. 2008
    ....
  41. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
    ..The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function...
  42. ncbi Habits, rituals, and the evaluative brain
    Ann M Graybiel
    Department of Brain and Cognitive Science and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 31:359-87. 2008
    ..Culturally based rituals may reflect privileged interactions between the basal ganglia and cortically based circuits that influence social, emotional, and action functions of the brain...
  43. ncbi Comparing dynamic causal models
    W D Penny
    Wellcome Department of Imaging Neuroscience, University College London, London, UK
    Neuroimage 22:1157-72. 2004
    ..The combined use of Bayes factors and DCM thus allows one to evaluate competing scientific theories about the architecture of large-scale neural networks and the neuronal interactions that mediate perception and cognition...
  44. ncbi Two systems of resting state connectivity between the insula and cingulate cortex
    Keri S Taylor
    Division of Brain, Imaging and Behavior Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
    Hum Brain Mapp 30:2731-45. 2009
    ....
  45. pmc Development of large-scale functional brain networks in children
    Kaustubh Supekar
    Graduate Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 7:e1000157. 2009
    ....
  46. ncbi Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
    ..It was hypothesized that the default mode network would show abnormal activation and connectivity in patients with schizophrenia...
  47. ncbi Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect
    Biyu J He
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 53:905-18. 2007
    ..Lastly, disconnection of the white matter tracts connecting frontal and parietal cortices was associated with more severe neglect and more disrupted functional connectivity. These findings support a network view in understanding neglect...
  48. ncbi Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study
    Nikos Makris
    Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, USA
    Cereb Cortex 15:854-69. 2005
    ..Since DT-MRI allows the precise definition of only the stem portion of each fiber pathway, the origin and termination of the subdivisions of SLF are extrapolated from the available data in experimental material from non-human primates...
  49. ncbi Prefrontal phase locking to hippocampal theta oscillations
    Athanassios G Siapas
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 46:141-51. 2005
    ..The theta-entrained activity across cortico-hippocampal circuits described here may be important for gating information flow and guiding the plastic changes that are believed to underlie the storage of information across these networks...
  50. pmc The development of human functional brain networks
    Jonathan D Power
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 67:735-48. 2010
    ....
  51. ncbi The big and the small: challenges of imaging the brain's circuits
    Jeff W Lichtman
    Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Science 334:618-23. 2011
    ..These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain...
  52. ncbi The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
    Craig W Berridge
    Departments of Psychology and Psychiatry, University of Wisconsin, Madison, WI 53706, USA
    Brain Res Brain Res Rev 42:33-84. 2003
    ....
  53. ncbi Studying the human brain anatomical network via diffusion-weighted MRI and Graph Theory
    Yasser Iturria-Medina
    Neuroimaging Department, Cuban Neuroscience Center, Avenue 25, Esq 158, 15202, PO Box 6412, Cubanacan, Playa, Havana, Cuba
    Neuroimage 40:1064-76. 2008
    ..These results are in agreement with previous anatomical studies in the cat and macaque cerebral cortex...
  54. ncbi Autism and abnormal development of brain connectivity
    Matthew K Belmonte
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 2AH, United Kingdom
    J Neurosci 24:9228-31. 2004
  55. ncbi Evidence for segregated and integrative connectivity patterns in the human Basal Ganglia
    Bogdan Draganski
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 28:7143-52. 2008
    ..We believe that this method can be used to examine pathophysiological concepts in a number of basal ganglia-related disorders...
  56. ncbi Parcellation-dependent small-world brain functional networks: a resting-state fMRI study
    Jinhui Wang
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Hum Brain Mapp 30:1511-23. 2009
    ..This study provides quantitative evidence on how the topological organization of brain networks is affected by the different parcellation strategies applied...
  57. ncbi Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
    S N Haber
    Department of Neurobiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 20:2369-82. 2000
    ..This anatomical arrangement creates a hierarchy of information flow and provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain...
  58. ncbi Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers
    V J Wedeen
    Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 41:1267-77. 2008
    ..These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy...
  59. pmc Tractography: where do we go from here?
    Saad Jbabdi
    FMRIB Centre, University of Oxford, United Kingdom
    Brain Connect 1:169-83. 2011
    ....
  60. ncbi Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry
    Marcel Adam Just
    Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:951-61. 2007
    ..The results add support to a new theory of cortical underconnectivity in autism, which posits a deficit in integration of information at the neural and cognitive levels...
  61. pmc Network structure of cerebral cortex shapes functional connectivity on multiple time scales
    Christopher J Honey
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 104:10240-5. 2007
    ....
  62. ncbi Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
    ..By replicating the major features of these tracts identified by histological techniques in monkey, we show that DSI has the potential to cast new light on the organization of the human brain in the normal state and in clinical disorders...
  63. ncbi Virtual in vivo interactive dissection of white matter fasciculi in the human brain
    Marco Catani
    Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuroimage 17:77-94. 2002
    ....
  64. pmc Brain anatomical network and intelligence
    Yonghui Li
    LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    PLoS Comput Biol 5:e1000395. 2009
    ..Our findings suggest that the efficiency of brain structural organization may be an important biological basis for intelligence...
  65. pmc A method for functional network connectivity among spatially independent resting-state components in schizophrenia
    Madiha J Jafri
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Neuroimage 39:1666-81. 2008
    ..Significant differences between patient and control connectivity in different networks were revealed possibly reflecting deficiencies in cortical processing in patients...
  66. ncbi Small-world and scale-free organization of voxel-based resting-state functional connectivity in the human brain
    M P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, Utrecht, The Netherlands
    Neuroimage 43:528-39. 2008
    ....
  67. pmc Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies
    Xun Liu
    Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    Neurosci Biobehav Rev 35:1219-36. 2011
    ..Neurobiological theories of reward-related decision making should therefore take distributed and interrelated representations of reward valuation and valence assessment into account...
  68. ncbi Functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain
    Martijn P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 30:3127-41. 2009
    ..Our results suggest that the functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain...
  69. ncbi The prefrontal cortex and cognitive control
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Neurosci 1:59-65. 2000
    ..Studies indicate that the prefrontal cortex is central in this process. It provides an infrastructure for synthesizing a diverse range of information that lays the foundation for the complex forms of behaviour observed in primates...
  70. ncbi Topography of the human corpus callosum revisited--comprehensive fiber tractography using diffusion tensor magnetic resonance imaging
    Sabine Hofer
    Biomedizinische NMR Forschungs GmbH am Max Planck Institut für biophysikalische Chemie, 37070 Gottingen, Germany
    Neuroimage 32:989-94. 2006
    ..In conclusion, DTI-based fiber tractography of healthy human subjects suggests a modification of the widely accepted Witelson scheme and a new classification of vertical CC partitions...
  71. ncbi A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis
    Florian Kurth
    C and O Vogt Institute of Brain Research, University Düsseldorf, Dusseldorf, Germany
    Brain Struct Funct 214:519-34. 2010
    ....
  72. ncbi The primate basal ganglia: parallel and integrative networks
    Suzanne N Haber
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Chem Neuroanat 26:317-30. 2003
    ..Information is channeled from limbic, to cognitive, to motor circuits. Action decision-making processes are thus influenced by motivation and cognitive inputs, allowing the animal to respond appropriate to environmental cues...
  73. pmc Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response
    Nick Medford
    Department of Psychiatry, Brighton and Sussex Medical School, Falmer Campus, Brighton, BN1 9PX, UK
    Brain Struct Funct 214:535-49. 2010
    ..Correspondingly, autonomic nervous system reactivity is particularly important amongst the responses that accompany conscious experiences. Potential clinical implications are also discussed...
  74. ncbi Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biol Psychiatry 57:1079-88. 2005
    ..In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls...
  75. ncbi Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources
    Cornelis J Stam
    Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 28:1178-93. 2007
    ....
  76. ncbi Fiber tracking: principles and strategies - a technical review
    Susumu Mori
    Johns Hopkins University School of Medicine, Department of Radiology and Radiological Science, Baltimore, MD 21205, USA
    NMR Biomed 15:468-80. 2002
    ..Special attention is paid to situations where complications may arise, and possible solutions are reviewed. Validation issues and potential future directions and improvements are also discussed...
  77. ncbi Disease and the brain's dark energy
    Dongyang Zhang
    Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Nat Rev Neurol 6:15-28. 2010
    ..To end the article, we explore some of the basic science pursuits that have been undertaken to further understand the physiology behind intrinsic activity as imaged with BOLD fMRI...
  78. ncbi Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
    ..Applying measures of neural integration and complexity, together with an analysis of extensive neurological data, leads to a testable proposal-the dynamic core hypothesis-about the properties of the neural substrate of consciousness...
  79. pmc Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification
    Kegang Hua
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 39:336-47. 2008
    ..Excellent correlation was found between the automated and the individual tractography-based results. This tool allows efficient initial screening of the status of multiple white matter tracts...
  80. ncbi Asymmetry analysis of cingulum based on scale-invariant parameterization by diffusion tensor imaging
    Gaolang Gong
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Hum Brain Mapp 24:92-8. 2005
    ..More interestingly, a significant left-greater-than-right asymmetry pattern was obtained in most segments of cingulum bundle (-50-25 degrees), except in the most posterior portion of cingulum (25-50 degrees)...
  81. ncbi Behavioral theories and the neurophysiology of reward
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
    Annu Rev Psychol 57:87-115. 2006
    ..The neural activity can be related to basic theoretical terms of reward and uncertainty, such as contiguity, contingency, prediction error, magnitude, probability, expected value, and variance...
  82. ncbi Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, CA 94301 5719, USA
    J Cogn Neurosci 16:1484-92. 2004
    ....
  83. ncbi A tension-based theory of morphogenesis and compact wiring in the central nervous system
    D C Van Essen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 385:313-8. 1997
    ..By keeping the aggregate length of axonal and dendritic wiring low, tension should contribute to the compactness of neural circuitry throughout the adult brain...
  84. pmc Time-frequency dynamics of resting-state brain connectivity measured with fMRI
    Catie Chang
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Neuroimage 50:81-98. 2010
    ....
  85. ncbi Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization
    Matthias Beckmann
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 29:1175-90. 2009
    ..Regional functional specialization was found to be related to regional differences in probabilistic anatomical connectivity...
  86. ncbi Functional connectivity patterns of human magnetoencephalographic recordings: a 'small-world' network?
    C J Stam
    Department of Clinical Neurophysiology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurosci Lett 355:25-8. 2004
    ..This might reflect an optimal organization pattern for information processing, connecting any two brain area by only a small number of intermediate steps...
  87. pmc Tracking neuronal fiber pathways in the living human brain
    T E Conturo
    Department of Radiology and Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:10422-7. 1999
    ..This approach enhances the power of modern imaging by enabling study of fiber connections among anatomically and functionally defined brain regions in individual human subjects...
  88. ncbi Connectivity-Based Parcellation of Broca's Area
    A Anwander
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Cereb Cortex 17:816-25. 2007
    ..For the first time, there is a possibility to investigate the anatomical subdivision of Broca's area noninvasively in the individual living human subject...
  89. ncbi Perisylvian language networks of the human brain
    Marco Catani
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AZ, United Kingdom
    Ann Neurol 57:8-16. 2005
    ..The anatomical findings are also relevant to the evolution of language, provide a framework for Lichtheim's symptom-based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language...
  90. pmc Central neural pathways for thermoregulation
    Shaun F Morrison
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci (Landmark Ed) 16:74-104. 2011
    ..This review summarizes the functional organization of the neural pathways through which cutaneous thermal receptors alter thermoregulatory effectors: the cutaneous circulation for ..
  91. ncbi Natural frequencies of human corticothalamic circuits
    Mario Rosanova
    Department of Clinical Sciences, Luigi Sacco, Universita degli Studi di Milano, Milan, Italy
    J Neurosci 29:7679-85. 2009
    ..The natural frequency can be directly measured in virtually any area of the cerebral cortex and may represent a straightforward and flexible way to probe the state of human thalamocortical circuits at the patient's bedside...
  92. ncbi Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
    Leopoldo Petreanu
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nat Neurosci 10:663-8. 2007
    ..In both hemispheres the L2/3-to-L5 projection is stronger than the L2/3-to-L2/3 projection. Our results suggest that laminar specificity may be identical for local and long-range cortical projections...
  93. ncbi DTI tractography of the human brain's language pathways
    Matthew F Glasser
    Department of Anthropology, Emory University, 1557 Dickey Drive, Atlanta, GA 30322, USA
    Cereb Cortex 18:2471-82. 2008
    ..Smaller right hemisphere MTG terminations overlapped with right lateralized prosodic activations. We combine our findings with a recent model of brain language processing to explain 6 aphasia syndromes...
  94. ncbi The evolution of the arcuate fasciculus revealed with comparative DTI
    James K Rilling
    Department of Anthropology, Emory University, 207 Anthropology Building, 1557 Dickey Drive, Atlanta, Georgia 30322, USA
    Nat Neurosci 11:426-8. 2008
    ..This human specialization may be relevant to the evolution of language...
  95. ncbi Cortical midline structures and the self
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Trends Cogn Sci 8:102-7. 2004
    ..All of these subfunctions are related to distinct regions within the CMS. This relationship between self-referential processing and CMS might provide novel insight into the neural correlates underlying the constitution of the self...
  96. ncbi Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey
    M Petrides
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, H3A B4 Canada
    Eur J Neurosci 16:291-310. 2002
    ..e. the auditory association cortex) and the multimodal cortex in the upper bank of the superior temporal sulcus...
  97. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  98. ncbi Functional MRI of language: new approaches to understanding the cortical organization of semantic processing
    Susan Bookheimer
    Brain Mapping Center, UCLA School of Medicine, 90095, USA
    Annu Rev Neurosci 25:151-88. 2002
    ..Together, these lines of research broaden our understanding of how the brain stores, retrieves, and makes sense of semantic information, and they challenge some commonly held notions of functional modularity in the language system...
  99. ncbi Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032, USA
    Neuron 51:871-82. 2006
    ..These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex...
  100. ncbi Cerebellar cortical organization: a one-map hypothesis
    Richard Apps
    Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Nat Rev Neurosci 10:670-81. 2009
    ..Here we consider the possibility that this complexity hides the fact that the cerebellar cortex contains only one map, which has been charted in various ways...
  101. pmc Identifying neural drivers with functional MRI: an electrophysiological validation
    Olivier David
    INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    PLoS Biol 6:2683-97. 2008
    ..As such, it has important implications for future studies on brain connectivity using functional neuroimaging...

Research Grants70

  1. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Little is known about the neural pathways and mechanism for detecting toxins...
  2. MUCOCILIARY TRANSPORT--INHIBITORY NEURAL REGULATION
    DONOVAN YEATES; Fiscal Year: 2003
    DESCRIPTION (Applicant's abstract): We have discovered novel inhibitory neural pathways which interact with excitatory neural reflexes to regulate tracheobronchial mucociliary function...
  3. CNS Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2004
    ..Elucidating neural pathways underlying the regulation of counterregulatory responses, and of epinephrine in particular, will aid in ..
  4. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Pharmacological agents will then be per'fused to block specific neural pathways to identify the underlying neuronal mechanisms...
  5. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..Studies of regulation of secretion have used various models. Intact animal studies have defined some neural pathways and endocrine and paracrine effectors...
  6. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  7. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..The aim of the R00 is to build on the K99 to investigate neural pathways associated with genetic obesity risk which could mediate the effect of genes on appetite and weight...
  8. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..The aim of the R00 is to build on the K99 to investigate neural pathways associated with genetic obesity risk which could mediate the effect of genes on appetite and weight...
  9. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..MDD is thought to arise from the interaction of environmental and genetic factors within multiple neural pathways, but progress has been hindered by our limited understanding of circuit-level endophenotypes in humans...
  10. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
    ..However, failure to identify the neural pathways through which such signals access reproductive circuits has impeded our understanding of how human "..
  11. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..Our long-term goal is to identify the central neural pathways and mechanisms by which glucocorticoids and stress modulate central nervous system control of cardiovascular ..
  12. PERIPHERAL AND CENTRAL INTERACTIONS IN ENERGY BALANCE
    Barbara B Kahn; Fiscal Year: 2010
    ..This included the neural pathways activated by leptin and the cellular pathways engaged by leptin in the CMS and skeletal muscle...
  13. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..behaviors in anorexia nervosa (AN) and bulimia nervosa (BN), through effects on inhibitory and reward neural pathways. In order to avoid the confounding effects of malnutrition, and because they have behaviors and neural ..
  14. Immediate and Delayed Effects of Morphine on Brain Circuits: Animal and Human Cor
    Dusica Bajic; Fiscal Year: 2013
    ..This suggests that early postnatal opioid treatment runs the risk of significant alterations in neural pathways. Studies have demonstrated significant dose-related decreases in the amygdala volume and connectivity after ..
  15. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..The identity of the specific metabolic signals or afferent neural pathways that convey information about energy balance to gonadotropin-releasing hormone (GnRH) neurons, the central ..
  16. Neurochemistry/physiology of proopiomelanocortin neurons
    MALCOLM JAMES LOW; Fiscal Year: 2013
    ..These neural pathways are candidate targets for the development of new pharmacotherapies aimed at reversing the obesity epidemic ..
  17. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..of itch are mediated by histamine signaling, recent work by us and others makes clear that additional key neural pathways are at play...
  18. Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
    Philipp E Scherer; Fiscal Year: 2013
    ..that are ideally positioned to serve as a link between peripheral metabolic and inflammatory signals and the neural pathways controlling hepatic and whole body glucose homeostasis...
  19. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    ..PGE2 binding to EP3 inhibitory receptors on neurons in the POA increases core body temperature by activating neural pathways to four principal thermoregulatory effectors: increased heat production from brown adipose tissue (BAT) ..
  20. Cholecystokinin - Role in postprandial gastric motility
    Helen E Raybould; Fiscal Year: 2013
    ..Therefore, it is important to understand the mechanisms by which nutrients are sensed in the gut, the neural pathways activated, and how these may be altered by long term changes in diet leading to increased food intake and ..
  21. Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associated
    JEREL ADAM FIELDS; Fiscal Year: 2013
    ..proper functioning mitochondria fission/fusion processes are necessary for maintaining and constructing new neural pathways. Interference may lead to neurodegeneration via toxic viral proteins: 1...
  22. Oxidant Stress in the Brain and Hypertension
    Robin L Davisson; Fiscal Year: 2013
    ..However, our understanding of how AngII- induced ROS formation in the SFO translates into powerful effects on neural pathways controlling blood pressure is still incomplete...
  23. Central Nervous System Mechanisms of Obesity Hypertension
    Sean D Stocker; Fiscal Year: 2012
    ..body weight or adiposity and activation of the sympathetic nervous system, little is known regarding the neural pathways and cellular mechanisms that underlie the sustained increase in sympathetic outflow and arterial blood ..
  24. Genetic Susceptibility to PCB-induced Motor Dysfunction
    CHRISTINE PERDAN CURRAN; Fiscal Year: 2012
    ..The proposed research is designed to identify neural pathways affected by PCB exposure and humans at highest risk of PCB developmental neurotoxicity using a mouse model ..
  25. Sex-specific genetic architecture of irritable bowel syndrome
    Lisa A Kilpatrick; Fiscal Year: 2013
    ..Together, the proposed studies will enhance knowledge of genetic and neural pathways influencing pain sensitivity in IBS and enable the candidate to propose new testable hypotheses regarding ..
  26. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..It is crucial to understand how neural pathways regulate body weight and find approaches to prevent and treat obesity...
  27. Characterization of the Transcriptome in an Emerging Model for Social Behavior
    James W Thomas; Fiscal Year: 2010
    ..Comparative studies between vole species have already led to the identification of several genes and neural pathways that contribute to variation in social behaviors, yet, largely because of a lack of genomic resources for ..
  28. GCs, CRF and Stressor-Induced Relapse
    John R Mantsch; Fiscal Year: 2013
    ..The project focuses on neuroplasticity involving the regulation of neural pathways underlying drug use by corticotropin-releasing factor (CRF), a neuropeptide previously implicated in stress ..
  29. Sp4 Pathway in the Modulation of Sensorimotor Gating and Memory
    XIANJIN ZHOU; Fiscal Year: 2013
    ..This renewal application investigates how Sp4 regulates expression of NMDAR1 proteins to modulate neural pathways involved in sensorimotor gating and cognitive functions...
  30. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..electrophysiological and neuropharmacological studies will be carried out to characterize the role of sensory neural pathways in cross-sensitization between the colon and urinary bladder...
  31. Neurogenetic Model of Social Behavior Heterogeneity in Autism Spectrum Disorders
    Michael L Platt; Fiscal Year: 2010
    ..variation in key genes impairs these behaviors in humans and rhesus in similar ways;and the same underlying neural pathways mediate the extraction of social information from the environment, translation of that information into ..
  32. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..We will study the reflexive and modulatory neural pathways using light and electron microscopy, recordings, and lesions. The experimental model will be rodents...
  33. Retraining Spinal Circuits With Robot-Assisted Functional Electrical Stimulation
    Deborah Won; Fiscal Year: 2013
    ..stimulation to robotically controlled movements in complete spinal cord transected (ST) rodents so that the neural pathways between the spinal cord and muscles will be stimulated at appropriate times to reinforce spinal circuits...
  34. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2012
    ..and newly emerged spinal reflexes after SCI to restore the lost functions, rather than further damaging the neural pathways by dorsal rhizotomy...
  35. PREMOTOR CONTROL OF UPPER AIRWAY AND REM SLEEP ATONIA
    LESZEK K KUBIN; Fiscal Year: 2012
    ..We plan to use a rodent model to study the neural pathways responsible for increased activity in the muscles that keep the airway open in OSAS patients and to determine ..
  36. Role of Redox-Mediated Activation of NFkappaB and AP-1 in Neurogenic Hypertension
    Robin L Davisson; Fiscal Year: 2010
    ..molecular mechanisms by which excessive oxidant production translates into long-lasting effects on central neural pathways controlling blood pressure are unknown...
  37. Neural Interface and Control Design to Restore Sensation in Amputees
    MATTHEW ANTHONY SCHIEFER; Fiscal Year: 2012
    ..Although the sensory receptors are missing in the amputated limb, the neural pathways that once carried sensory information remain intact and can be excited with electrical stimulation, thus ..
  38. Mechanisms of Neurogenic Bladder Dysfunction in EAE Mice
    Firouz Daneshgari; Fiscal Year: 2010
    ..NUI remains poorly understood, it is suggested that NBD occurs as a result of demyelination interrupting the neural pathways connecting the central nervous system control to the spinal and peripheral neuronal pathways of the bladder ..
  39. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia-Klein; Fiscal Year: 2013
    ..We hypothesize that aggressive participants will have sensitized functional neural pathways of emotional reactivity and reductions in the pathways underlying executive control...
  40. Hypothalamic GABAergic Action and Energy Homeostasis
    Qingchun Tong; Fiscal Year: 2010
    ..understanding the function of glutamate and GABA in hypothalamic neurocircuits is key to identify important neural pathways that can be ultimately targeted for obesity prevention and therapeutics...
  41. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..fat diet consumption and obesity, 2) define critical periods of susceptibility to metabolic perturbations on neural pathways involved in energy balance and 3) investigate the role of epigenetic changes as mediating mechanisms...
  42. NEURAL PATHWAYS UNDERLYING EMOTIONAL CONDITIONING
    Joseph E LeDoux; Fiscal Year: 2013
    ..The neural pathways involved include transmission of CS information from the auditory system to the lateral amygdala (LA), where ..
  43. VESTIBULAR REGULATION OF RESPIRATORY MUSCLE ACTIVITY
    Bill J Yates; Fiscal Year: 2013
    ..The proposed experiments comprise the first systematic study of how vestibular signals are transformed by the neural pathways that trigger and coordinate vomiting and will also ascertain how inputs from the viscera affect this ..
  44. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    Paul E Sawchenko; Fiscal Year: 2012
    ..of CRF ligand-containing inputs to hippocampus, and then test experimentally the involvement of implicated neural pathways. Third, we will characterize the effects of repeated exposure to emotional stress on tau-P and A[unreadable] ..
  45. Examining the neural circuit for an instinctive olfactory-induced behavior in lar
    Scott T Laughlin; Fiscal Year: 2013
    ..One of the overarching goals in the field of olfactory neurobiology is to understad the neural pathways that connect an olfactory stimulus, its representation in the brain as a percept, and the circuits that drive ..
  46. Development of neuronal tracers to study leptin modulation of dopamine circuits
    Ralph J DiLeone; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Defining the neural pathways and circuits of the brain is critical for understanding neurological and psychiatric disease...
  47. Mice Harboring Human DISC1-Boymaw Fusion Transcripts
    XIANJIN ZHOU; Fiscal Year: 2010
    ..Understanding of the effects of these fusion transcripts will help elucidate the molecular and neural pathways for the pathogenesis of schizophrenia, as well as improve diagnosis and guide the development of effective ..
  48. Synaptic mechanisms of temporal pattern recognition
    Christa A Baker; Fiscal Year: 2012
    ..A thorough knowledge of how intact neural pathways perform operations critical for sensory perception is vital to research that seeks to identify the underlying ..
  49. Bladder, Urethra and Anal Sphincter Reinnervation
    MICHAEL RAYMOND RUGGIERI; Fiscal Year: 2013
    ..These patients require new neural pathways to regain control of bladder function...
  50. Characterization of Sexual Dimorphism in the Brain
    NIRAO MAHESH SHAH; Fiscal Year: 2013
    ..provided by applicant): The goal of our grant application is a functional and anatomic dissection of the neural pathways emanating from the mouse medial amygdala (MeA)...
  51. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2013
    ..develop accurate, quantitative models, capable of distinguishing changes in muscular system from changes in neural pathways in neurological disorders such as SCI...
  52. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
    ..the chemical messengers that convey signals along these pathways and the contributions of two distinct neural pathways to the initiation and shaping of vocal responses...
  53. Regulation of Masking and Circadian Rhythm Phase
    Lawrence P Morin; Fiscal Year: 2012
    ..project utilizes novel light stimuli, new test procedures and mouse models to discern which photoreceptors, neural pathways and brain regions contribute to rhythm timing and to the ability of light to suppress locomotion and induce ..
  54. Sensorimotor control of the oropharynx and esophagus
    RODERICK ATKINS SUTHERS; Fiscal Year: 2013
    ..and neurophysiological techniques to map the premotor pathways of the cranial nerves in order to identify the neural pathways by which auditory information accesses the motoneurons to muscles of the upper vocal tract and to look for ..
  55. A Role for Endocannabinoids in the Control of Dietary Fat Intake
    NICHOLAS VINCENT DIPATRIZIO; Fiscal Year: 2013
    ..gene transcripts and proteins involved in eCB metabolism;(iii) to identify oral fatty-acid receptors an neural pathways that maintain intestinal eCB mobilization and fat intake by investigating the ability for fat sham feeding to ..
  56. The role of octopamine receptor-expressing neurons in aggression.
    ERIC DOMINGUEZ HOOPFER; Fiscal Year: 2012
    ..of aggressive behavior? How do these Oa2 neuronal circuits function to mediate aggression and what are the neural pathways that they modulate? I will address these questions with the following specific aims: Aim 1- Loss-of-function ..
  57. Effects of adolescent alcohol exposure on sleep and arousal in adulthood
    Cindy L Ehlers; Fiscal Year: 2013
    ..Thus, we postulate that a disruption in these neural pathways lead to disruptions in sleep and arousal and facilitates changes in tolerance to alcohol and excessive ..
  58. Sensorimotor loops in vibrissa somatosensation
    David Kleinfeld; Fiscal Year: 2013
    ..from motor cortex control the region of interest of rhythmic whisking? The interpretation of touch in neural pathways depends on how the region of interest that shape vibrissa movements are regulated...
  59. Retrograde Tracers with Suicide Enzyme?Prodrug to Study Specific Neural Circuits
    Xinmin Simon Xie; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tracing techniques have long been used to analyze specific neural pathways but do not reveal their function...
  60. Childhood Maltreatment:Biomarkers of Risk and Resilience
    AUDREY TYRKA; Fiscal Year: 2013
    ..Genes that regulate monoamine or HPA axis function will be examined based on involvement in neural pathways implicated in these behavioral problems as well as prior empirical associations with internalizing disorders ..
  61. Neural Mechanisms of sound intensity coding
    Katrina M MacLeod; Fiscal Year: 2013
    ..Different aspects of sound are extracted from the auditory nerve spike trains and encoded via parallel neural pathways. While the coding of timing cues have been studied extensively, the processing of intensity cues remains ..
  62. Origins of neuronal patterning in animal development
    MICHAEL JOHN LAYDEN; Fiscal Year: 2010
    ..comparative studies between invertebrate and vertebrate model animals and promote identification conserved neural pathways. Additionally, Nematostella will provide a model system for studying neural regeneration mechanisms...
  63. Developmental Mechanisms Underlying Risk Behaviors and Their Treatment
    Kai Christian Sonntag; Fiscal Year: 2013
    ..approach that encompasses behavioral and molecular analyses to examine neuronal function within well-defined neural pathways in the rodent brain of both males and females...
  64. Investigation of Cortical Changes Following Spinal Cord Injury
    Jennifer L Collinger; Fiscal Year: 2012
    ..However, following SCI, the disruption of efferent and afferent neural pathways likely leads to changes at the level of the brain...
  65. The Genetics of Parallel Reproductive Isolation in Stickleback Species Pairs
    Catherine L Peichel; Fiscal Year: 2012
    ..the genetic basis of behavioral variation and behavioral disorders in humans because many of the genetic and neural pathways that underlie behaviors are likely to be conserved between fish and humans...
  66. Putting habenula pathways on the map
    Eric E Turner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This is a new R01 proposal addressing neural pathways and gene expression in habenula- midbrain circuits...
  67. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    The control of gastric motility and emptying following a meal is mediated by both hormonal and neural pathways. The aim of this proposal is to establish a role for cholecystokinin (CCK) in mediating changes in motility and emptying in ..
  68. Complex pitch perception in very-early implanted children
    Rosalie Uchanski; Fiscal Year: 2007
    ..deafened adult Cl user, electrical stimulation of the auditory nerve is subsequently processed by auditory neural pathways that had developed normally; pathways that, for example, once preserved a good tonotopic map at the auditory ..
  69. Working Memory Performance among Childhood Brain Tumor Survivors
    HEATHER CONKLIN; Fiscal Year: 2009
    ..Improved specification of cognitive changes following treatment is crucial for identifying vulnerable neural pathways and developing targeted interventions...
  70. GLUCOSE METABOLISM EFFECTS ON REPRODUCTIVE BEHAVIOR
    JILL SCHNEIDER; Fiscal Year: 2000
    ..are to better understand the nature of metabolic stimuli, the anatomical location of their detectors, and the neural pathways from the detectors to brain areas controlling reproductive cycles and behavior...