trigeminal ganglion

Summary

Summary: The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.

Top Publications

  1. ncbi Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
  2. pmc Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    Kamal M Khanna
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 18:593-603. 2003
  3. ncbi TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
  4. ncbi Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype
    Monique van Velzen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 183:2456-61. 2009
  5. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011
  6. pmc Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons
    Jeffrey J Iliff
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurochem 115:1530-42. 2010
  7. ncbi Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensation
    Laura S Gammill
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Dev Neurobiol 67:47-56. 2007
  8. pmc Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
    M Xiang
    Department of Molecular Biology, Johns Hopkins University School Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:11950-5. 1996
  9. ncbi Vertebrate cranial placodes I. Embryonic induction
    C V Baker
    Division of Biology 139 74, California Institute of Technology, Pasadena, California, 91125, USA
    Dev Biol 232:1-61. 2001
  10. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004

Research Grants

  1. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
  2. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
  3. Viral And host mechanisms that tilt the HSV lytic/latent balance
    Donald M Coen; Fiscal Year: 2013
  4. Estrogen and TMJ Pain
    Phillip R Kramer; Fiscal Year: 2013
  5. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
  6. THE ROLE FOR THE GPR30 RECEPTOR IN INFLAMMATORY PAIN
    Jill C Fehrenbacher; Fiscal Year: 2010
  7. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
  8. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
  9. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
  10. Chromatin and Herpes Simplex Virus Latency
    David M Knipe; Fiscal Year: 2013

Detail Information

Publications269 found, 100 shown here

  1. ncbi Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
    Within the trigeminal ganglion, crosstalk between neurons and satellite glial cells (SGCs) contributes to neuronal sensitization and transduction of painful stimuli, including migraine pain, at least partly through activation of ..
  2. pmc Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    Kamal M Khanna
    Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 18:593-603. 2003
    ..gB(498-505) HSV-1 epitope are selectively retained in the ophthalmic branch of the latently infected trigeminal ganglion, where they acquire and maintain an activation phenotype and the capacity to produce IFN-gamma...
  3. ncbi TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
    ..These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat...
  4. ncbi Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype
    Monique van Velzen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 183:2456-61. 2009
    ....
  5. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011
    ....
  6. pmc Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons
    Jeffrey J Iliff
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurochem 115:1530-42. 2010
    ..We previously described the expression of cytochrome P450-2J epoxygenase in rat trigeminal ganglion neurons and that EETs signaling is involved in cerebrovascular dilation resulting from perivascular nerve ..
  7. ncbi Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensation
    Laura S Gammill
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Dev Neurobiol 67:47-56. 2007
    ..In addition, trigeminal ganglia fail to form correctly in the mutants and are improperly condensed and loosely organized. These data show that npn2/sema3F signaling is required for proper cranial neural crest development in the head...
  8. pmc Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
    M Xiang
    Department of Molecular Biology, Johns Hopkins University School Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:11950-5. 1996
    ....
  9. ncbi Vertebrate cranial placodes I. Embryonic induction
    C V Baker
    Division of Biology 139 74, California Institute of Technology, Pasadena, California, 91125, USA
    Dev Biol 232:1-61. 2001
    ....
  10. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors...
  11. pmc Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia
    Georges M G M Verjans
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:3496-501. 2007
    ..In contrast, T cells do not seem to be directly involved in controlling VZV latency in human TG...
  12. ncbi Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells
    Yoshio Yamamoto
    Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Neurosci Lett 454:129-33. 2009
    ..Mean sizes of TREK-1, TREK-2 and TRAAK immunoreactive trigeminal ganglion neurons were 447+/-185, 445+/-23 and 492+/-12 mm2, respectively...
  13. pmc The differential expression of low-threshold K+ currents generates distinct firing patterns in different subtypes of adult mouse trigeminal ganglion neurones
    Luigi Catacuzzeno
    Dipartimento Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    J Physiol 586:5101-18. 2008
    In adult mouse trigeminal ganglion (TG) neurones we identified three neuronal subpopulations, defined in terms of their firing response to protracted depolarizations, namely MF neurones, characterized by a multiple tonic firing; DMF ..
  14. pmc Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neurons
    Xingmei Feng
    Department of Neurobiology, Institute of Neuroscience, Key Laboratory of Pain Research and Therapy, Soochow University, Suzhou 215123, China
    Mol Pain 9:4. 2013
    ..However, the role and mechanism for H2S in nociceptive processing in trigeminal ganglion (TG) neuron remains unknown...
  15. pmc Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse
    Ine Vandewauw
    Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine and TRP Research Platform Leuven, KU Leuven, Leuven, Belgium
    BMC Neurosci 14:21. 2013
    ....
  16. ncbi Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist
    Ranjinidevi Ambalavanar
    Department of Biomedical Sciences, University of Maryland, Baltimore, 21201, USA
    Pain 120:53-68. 2006
    ..Elevated levels of calcitonin gene-related peptide (CGRP) within the trigeminal ganglion temporally correlated with this mechanical allodynia...
  17. pmc Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine
    B Fioretti
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, 35121 Padova, Italy
    J Physiol 589:5879-95. 2011
    ..Here we studied the calcium currents and excitability properties of two subpopulations of small-diameter trigeminal ganglion (TG) neurons from adult wild-type (WT) and R192Q FHM1 knockin (KI) mice: capsaicin-sensitive neurons ..
  18. ncbi PACAP induces neurite outgrowth in cultured trigeminal ganglion cells and recovery of corneal sensitivity after flap surgery in rabbits
    Chiho Fukiage
    Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Kobe, Hyogo, Japan
    Am J Ophthalmol 143:255-262. 2007
    ..adenylate cyclase-activating polypeptide (PACAP) to induce growth of neuronal processes in cultured trigeminal ganglion cells, and to accelerate neurite outgrowth and recovery of corneal sensitivity after creation of a corneal ..
  19. pmc Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats
    Ayano Katagiri
    Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan
    Mol Pain 8:23. 2012
    ..stimulation of the tongue, P2Y12R and glial fibrillary acidic protein (GFAP) immunohistochemistries in the trigeminal ganglion (TG) in a rat model of unilateral lingual nerve crush (LNC) to evaluate role of P2Y12R in SGC in lingual ..
  20. ncbi Expression of P2X₁ and P2X₄ receptors in rat trigeminal ganglion neurons
    Hidetaka Kuroda
    Oral Health Science Center hrc8, Tokyo Dental College, Chiba, Japan
    Neuroreport 23:752-6. 2012
    ..the contribution of P2X₃ and/or P2X(2/3) receptors toward the pain mechanism is well described in trigeminal ganglion neurons, the expression of other subtypes of P2X receptor remains to be clarified...
  21. pmc Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses
    Nicole Schöbel
    Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e48005. 2012
    ..In summary, our results strongly argue for a Ca(2+)-activated Cl(-)-dependent signal amplification mechanism in TG neurons that requires intracellular Cl(-) accumulation by NKCC1 and the activation of CaCCs...
  22. ncbi p75 is important for axon growth and schwann cell migration during development
    C A Bentley
    The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 20:7706-15. 2000
    ..Electron microscopy studies of the axons of the trigeminal ganglion at E13...
  23. pmc Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine
    Alessia Franceschini
    Department of Neuroscience and Italian Institute of Technology Unit, International School for Advanced Studies SISSA, via Bonomea 265, Trieste, 34136, Italy
    BMC Neurosci 13:143. 2012
    Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine...
  24. pmc Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice
    T Akiyama
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    J Neurophysiol 104:2442-50. 2010
    ..Calcium imaging of primary sensory trigeminal ganglion (TG) cells showed that 15.4% responded to histamine, 5...
  25. pmc Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions
    Mei Xu
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Pain 9:1036-48. 2008
    ..Nerve injury marker ATF3 was markedly increased in ipsilateral trigeminal ganglion neurons at 8 days after pIONL...
  26. pmc TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation
    Phillip Edward Kunkler
    The Department of Biochemistry and Molecular Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pain 152:38-44. 2011
    ..We suggest that these events contribute to headache associated with environmental irritants...
  27. pmc Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons
    L Tarsa
    Department of Integrative Biosciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA
    Neuroscience 167:1205-15. 2010
    Nociceptive pathways with first-order neurons located in the trigeminal ganglion (TG) provide sensory innervation to the head, and are responsible for a number of common chronic pain conditions, including migraines, temporomandibular ..
  28. ncbi Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation
    S E Shore
    Kresge Hearing Research Institute and Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Eur J Neurosci 21:3334-48. 2005
    ..We investigated trigeminal system influences on guinea pig DCN cells by stimulating the trigeminal ganglion while recording spontaneous and sound-driven activity from DCN neurons...
  29. ncbi Differential Changes in TRPV1 expression after trigeminal sensory nerve injury
    Hyun Yeong Kim
    Department of Physiology and Program in Molecular and Cellular Neuroscience, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
    J Pain 9:280-8. 2008
    ..In these animals, we found that neuronal loss of trigeminal ganglion (TG) was not correlated with pain hypersensitivity...
  30. pmc Can satellite glial cells be therapeutic targets for pain control?
    Luc Jasmin
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Neuron Glia Biol 6:63-71. 2010
    ..Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain...
  31. pmc Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain
    Guang Bai
    Department of Biomedical Sciences, Program in Neuroscience, University Maryland Dental School, Baltimore, MD, USA
    Mol Pain 3:15. 2007
    ..unilaterally into the rat masseter muscle and quantified changes in neuron-specific mature miRNAs in the trigeminal ganglion (TG)...
  32. ncbi Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, Kyungpook National University, Daegu, Korea
    J Comp Neurol 518:687-98. 2010
    ..To address this issue, we characterized the TRPA1-positive (+) neurons in the trigeminal ganglion (TG) and investigated the distribution of TRPA1(+) afferent fibers and their synaptic connectivity within ..
  33. pmc Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells
    Robert J Danaher
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Dentistry and College of Medicine, Lexington, KY 40536 0297, USA
    J Neurovirol 11:306-17. 2005
    ..e., recrudescence)...
  34. pmc A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
    Yunfu Sun
    Department of Medicine, University of California San Diego, La Jolla, California 93093, USA
    Nat Neurosci 11:1283-93. 2008
    ..Together these results establish a central role for Islet1 in the transition from sensory neurogenesis to subtype specification...
  35. pmc Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Virol 83:2246-54. 2009
    ....
  36. ncbi Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia
    K Tsuzuki
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pain 91:351-60. 2001
    ..peroneal nerves and the transection of the infraorbital nerve, and observed dorsal root ganglion (DRG) and trigeminal ganglion neurons, respectively...
  37. pmc Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice
    Megumi Aita
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Mol Pain 6:8. 2010
    ..BrdU) as a mitotic marker, we assessed cell proliferation in three different areas of the trigeminal afferent pathway: trigeminal nucleus principalis (Vp), trigeminal root entry zone (TREZ), and trigeminal ganglion (TG).
  38. ncbi Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy
    Paul L Durham
    Department of Biology, Southwest Missouri State University, MO, USA
    Headache 44:35-42; discussion 42-3. 2004
    ..To determine the effect of botulinum toxin type A on calcitonin gene-related peptide secretion from cultured trigeminal ganglia neurons...
  39. ncbi Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Cell Calcium 43:576-90. 2008
    ..At this exposure time, P2Y receptors responses in satellite glia were instead upregulated, suggesting a complex modulation of P2 receptors in pain signaling...
  40. pmc Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons
    V Staikopoulos
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Neuroscience 144:208-16. 2007
    ..examine the distribution of P2X2 and P2X3 receptors in primary afferent cell bodies in the rat trigeminal ganglion, including those innervating the dura...
  41. pmc A recombinant herpes simplex virus type 1 expressing two additional copies of gK is more pathogenic than wild-type virus in two different strains of mice
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars Sinai Burns and Allen Research Institute, CSMC D2024, 8700 Beverly Blvd, Los Angeles, California 90048, USA
    J Virol 81:12962-72. 2007
    ..Taken together, these results strongly suggest that increased gK levels promote eye disease and chronic infection in infected mice...
  42. ncbi Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone
    Hu Wang
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 498:390-402. 2006
    ..b>Trigeminal ganglion tissue sections were processed for single or double immunohistochemistry...
  43. ncbi Botulinum toxin type a (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction
    Y Kitamura
    Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neuroscience 159:1422-9. 2009
    ..Thus, we monitored the secretory activity of acutely dissociated trigeminal ganglion (TRG) neurons from naïve and IoNC rats by measuring the fluorescence intensity of the membrane-uptake ..
  44. pmc TRPA1 acts as a cold sensor in vitro and in vivo
    Yuji Karashima
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1273-8. 2009
    ..Second, we identify and characterize a specific subset of cold-sensitive trigeminal ganglion neurons that is absent in TRPA1-deficient mice...
  45. ncbi Effects of carbamazepine and amitriptyline on tetrodotoxinresistant Na+ channels in immature rat trigeminal ganglion neurons
    Yun Kyung Hur
    Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 700 412, Korea
    Arch Pharm Res 31:178-82. 2008
    ..peripheral nerve injury-induced pain, much less is known about the actions of these drugs on immature trigeminal ganglion (TG) neurons...
  46. pmc Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons
    Jin Tao
    Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurophysiol 107:1666-80. 2012
    ..of T666M, the most frequently occurring FHM-1 mutation, on VGCC currents and neuronal excitability in trigeminal ganglion (TG) neurons. We expressed human wild-type and T666M Ca(V)2.1 subunits in cultured TG neurons from Ca(V)2...
  47. pmc Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia
    Sylvia O Suadicani
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Neuron Glia Biol 6:43-51. 2010
    ..Focal electrical or mechanical stimulation of single neurons in trigeminal ganglion cultures increased intracellular calcium concentration in these cells and triggered calcium elevations in ..
  48. ncbi Hyperpolarization-activated cyclic-nucleotide gated 4 (HCN4) protein is expressed in a subset of rat dorsal root and trigeminal ganglion neurons
    Hyun Jung Cho
    Department Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Cell Tissue Res 338:171-7. 2009
    ..This population was not insignificant, comprising 5% of TG neurons and 2% of DRG neurons...
  49. ncbi Role of peripheral mu-opioid receptors in inflammatory orofacial muscle pain
    S Nunez
    Department of Biomedical Sciences, Program in Neuroscience, University of Maryland Baltimore School of Dentistry, 650 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 146:1346-54. 2007
    ..These results demonstrated that activation of peripheral MOR provides greater anti-nociception in inflamed muscle, and that the enhanced MOR effect can be partly explained by significant up-regulation of MOR expression in TG...
  50. pmc Herpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis
    Francisco J Branco
    Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:9019-25. 2005
    ..Furthermore, no HSV strain 17-infected trigeminal ganglion neurons were apoptotic, but 0.087% of 17deltaSty and 0.98% of 17 N/H-infected neurons were apoptotic...
  51. ncbi Adaptation of trigeminal ganglion cells to periodic whisker deflections
    George Fraser
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Somatosens Mot Res 23:111-8. 2006
    b>Trigeminal ganglion neurons in adult rats adapt to periodic whisker deflections in the range of 1-40 Hz, manifested as a reduction in spike counts to progressively later stimuli in a train of pulsatile or sinusoidal deflections...
  52. pmc Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion
    Yong Chen
    Department of Medicine, Duke University, Durham, NC, USA
    Pain 154:1295-304. 2013
    ..the pathogenetic contributions of the calcium-permeable TRPV4 ion channel, robustly expressed in the trigeminal ganglion sensory neurons, to TMJ inflammation and pain behavior...
  53. pmc Polysialylated-neural cell adhesion molecule (PSA-NCAM) in the human trigeminal ganglion and brainstem at prenatal and adult ages
    Marina Quartu
    Department of Cytomorphology, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato Cagliari, Italy
    BMC Neurosci 9:108. 2008
    ..potential for dynamic changes of specific neuronal populations in man, this study analyses the immunohistochemical occurrence of PSA-NCAM in the human trigeminal ganglion (TG) and brainstem neuronal populations at prenatal and adult age.
  54. pmc Histochemical evidence for microglia-like macrophages in the rat trigeminal ganglion
    J A Glenn
    Department of Oral Biology, College of Dentistry, Ohio State University, Columbus
    J Anat 183:475-81. 1993
    ..In the present study, this lectin was used to assess the existence of macrophages in the rat trigeminal ganglion. Vibratome sections of fixed ganglia were incubated with horseradish peroxidase (HRP)-conjugated isolectin, ..
  55. ncbi Development of rodent whisking: trigeminal input and central pattern generation
    Margo Landers
    Department of Psychology, Hunter College, City University of New York, NY 10021, USA
    Somatosens Mot Res 23:1-10. 2006
    ..They are discussed in relation to the development of pattern generating mechanisms in the rodent whisker system...
  56. pmc Two mechanisms involved in trigeminal CGRP release: implications for migraine treatment
    Paul L Durham
    Center for Biomedical and Life Sciences, Missouri State University, Springfield, MO, USA
    Headache 53:67-80. 2013
    ..A possible explanation is that triptans and onabotulinumtoxinA are not able to block proton-mediated CGRP secretion...
  57. ncbi Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine
    H J Cho
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Neuroscience 162:453-61. 2009
    ..HCN1 and HCN2 channel immunoreactivity was observed on the membranes of medium- to large-sized trigeminal ganglion neurons with 76% and 85% of HCN1 and HCN2 expressing neurons also containing the 200 kDa neurofilament ..
  58. ncbi AAN-EFNS guidelines on trigeminal neuralgia management
    G Cruccu
    Department of Neurological Sciences, La Sapienza University, Rome, Italy
    Eur J Neurol 15:1013-28. 2008
    ..The role of surgery versus pharmacotherapy in the management of TN in patients with multiple sclerosis remains uncertain...
  59. pmc Effects of LPS on P2X3 receptors of trigeminal sensory neurons and macrophages from mice expressing the R192Q Cacna1a gene mutation of familial hemiplegic migraine-1
    Alessia Franceschini
    Department of Neuroscience and Italian Institute of Technology Unit, International School for Advanced Studies SISSA, via Bonomea 265, 34136, Trieste, Italy
    Purinergic Signal 9:7-13. 2013
    ....
  60. ncbi Potentiation of 5-HT3 receptor function by the activation of coexistent 5-HT2 receptors in trigeminal ganglion neurons of rats
    Wang Ping Hu
    Laboratory of Neuropharmacology, Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China
    Neuropharmacology 47:833-40. 2004
    ..whether the activation of 5-HT2 and 5-HT1 receptors could modulate 5-HT3 receptor mediated current in rat trigeminal ganglion (TG) neurons using whole-cell patch clamp technique...
  61. pmc Nasal chemosensory-stimulation evoked activity patterns in the rat trigeminal ganglion visualized by in vivo voltage-sensitive dye imaging
    Markus Rothermel
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat, Bochum, Germany
    PLoS ONE 6:e26158. 2011
    ..known about the representation of volatile chemical stimuli at an early stage in the trigeminal system, the trigeminal ganglion (TG), which contains neurons directly projecting to the nasal cavity...
  62. pmc Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, Japan
    Mol Pain 7:5. 2011
    ..pain animal models, particularly the relationship between changes in Kv channels and the excitability of trigeminal ganglion (TRG) neurons...
  63. pmc IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells
    Lars Neeb
    Department of Neurology and Experimental Neurology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e17360. 2011
    ..The trigeminal ganglion and calcitonin gene-related peptide (CGRP) are crucial components in the pathophysiology of primary ..
  64. pmc Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spread
    B C Summers
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Virol 75:5069-75. 2001
    ..disease development occurs by zosteriform spread from the cornea to the periocular tissue via the trigeminal ganglion rather than by direct spread from cornea to the periocular skin...
  65. pmc Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache
    Jin Yan
    University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
    Pain 152:106-13. 2011
    ..These data provide a cellular mechanism by which decreased pH in the meninges following ischemic or inflammatory events directly excites afferent pain-sensing neurons potentially contributing to migraine headache...
  66. ncbi Neutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons
    Rashid Giniatullin
    Neurobiology Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 27:8190-201. 2007
    ..is proposed as a novel analgesic approach, its consequences on nociceptive purinergic P2X receptors of trigeminal ganglion neurons remain unknown...
  67. pmc A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro
    Andrea S Bertke
    Department of Ophthalmology, University of California, San Francisco, Medical Sciences Building, s 310, 513 Parnassus Ave, Box 0412, San Francisco, CA 94143 0412, USA
    J Virol 85:6669-77. 2011
    ..the establishment of HSV latency in specific subtypes of neurons, cultured dissociated adult murine trigeminal ganglion (TG) neurons were assessed for relative permissiveness for productive infection...
  68. pmc Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
    Lawrence T Feldman
    Department of Microbiology and Immunology, University of California Medical Center, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 99:978-83. 2002
    ..In the absence of detectable infectious virus in these ganglia, we propose the term "spontaneous molecular reactivation" to describe this ongoing process...
  69. pmc Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model
    Aswini Gnanasekaran
    Neurobiology Sector and Italian Institute of Technology Unit, International School for Advanced Studies, Trieste, Italy
    Mol Pain 7:77. 2011
    ..In an attempt to understand the basic mechanisms linked to the upregulation of P2X3 receptor activity, we investigated the influence of the lipid domain of these trigeminal sensory neurons on receptor compartmentalization and function...
  70. ncbi Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor
    M Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 148:744-56. 2007
    This study investigated whether somatostatin (SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch ..
  71. ncbi Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution
    Jochen K Lennerz
    Institute of Physiology and Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    J Comp Neurol 507:1277-99. 2008
    ..In the trigeminal ganglion, besides Schwann and satellite cells, CLR- and RAMP1-ir was found in subpopulations of CGRP-ir neurons ..
  72. ncbi Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line
    Eva Szoke
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Eur J Pharmacol 628:67-74. 2010
    ..Evidence for a supporting role of cholesterol, sphingomyelin and gangliosides were obtained both in native and TRPV1-transfected cells. Differential modulation of responses to capsaicin and RTX was often observed...
  73. ncbi Direct activation of transient receptor potential V1 by nickel ions
    Matthias Luebbert
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Pflugers Arch 459:737-50. 2010
    ..are able to induce non-specific cation currents in a capsaicin-sensitive population of cultured mouse trigeminal ganglion neurons...
  74. ncbi Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury
    James E Biggs
    Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, South Yorkshire S10 2TA, UK
    Eur J Pain 11:192-201. 2007
    ..tracer, fluorogold, was injected into the damaged nerve to identify associated cell bodies in the trigeminal ganglion. Three further ferrets, receiving only tracer injection, served as uninjured controls...
  75. ncbi The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system
    Romina Nassini
    Department of Preclinical and Clinical Pharmacology and Headache Centre, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Brain 135:376-90. 2012
    ..selectively stimulated transient receptor potential ankyrin 1-expressing HEK293 cells and rat trigeminal ganglion neurons, but not untransfected cells or neurons in the presence of the selective transient receptor ..
  76. ncbi Selectively targeting pain in the trigeminal system
    Hyun Yeong Kim
    National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110 749, Republic of Korea
    Pain 150:29-40. 2010
    ..QX-314 alone failed to block voltage-gated sodium channel currents (I(Na)) and action potentials (APs) in trigeminal ganglion (TG) neurons...
  77. ncbi Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model
    Jonas Eriksson
    Center for Oral Biology, Novum, Karolinska Institutet, P O Box 4064, S 141 04 Huddinge, Sweden
    Pain 119:82-94. 2005
    ..Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel alpha-..
  78. ncbi Trigeminal ganglion innervates the auditory brainstem
    S E Shore
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Comp Neurol 419:271-85. 2000
    A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made ..
  79. pmc Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus
    Giovanni Villa
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pain 6:89. 2010
    ....
  80. ncbi Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat
    Juan Miguel Jimenez-Andrade
    Neurosystems Center, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, United States
    Neurosci Lett 405:62-7. 2006
    ..To begin to define the type and location of sensory neurons most impacted by paclitaxel, we examined rat trigeminal ganglion, thoracic and lumbar dorsal root ganglion (DRG) 10 days following intravenous infusion of clinically ..
  81. ncbi Calcium homeostasis in trigeminal ganglion cell bodies
    Tony D Gover
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, MD 21201 1559, United States
    Cell Calcium 41:389-96. 2007
    ..Little is known about Ca2+ homeostasis in trigeminal ganglion neurons (TGNs)...
  82. ncbi Chronic electrostimulation of the trigeminal ganglion in trigeminal neuropathy: current state and future prospects
    J H Mehrkens
    Neurochirurgische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Acta Neurochir Suppl 97:91-7. 2007
    Over two decades ago, the electrostimulation of the trigeminal ganglion (TGES) was established as a treatment option for patients with trigeminopathic pain due to a (iatrogenic) lesion of the trigeminal nerve, on whom the other ..
  83. ncbi Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior
    R Ambalavanar
    Department of Biomedical Sciences and Program in Neuroscience, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 143:875-84. 2006
    ..A rapid and significant increase in CGRP mRNA occurred in the mandibular division (V3) of the ipsilateral trigeminal ganglion at 30 minutes, 4 and 24 h after the injection of complete Freund's adjuvant as an inflammatory agent into ..
  84. pmc Estrogen and inflammation increase the excitability of rat temporomandibular joint afferent neurons
    Natasha M Flake
    Department of Biomedical Sciences, Dental School, University of Maryland, 666 W Baltimore St, Rm 5 A 12, Baltimore, MD 21201, USA
    J Neurophysiol 93:1585-97. 2005
    ....
  85. ncbi Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation
    Alfonso Lagares
    Department of Anatomy, Histology, and Neuroscience, Autonoma University of Madrid, Medical School, 28029 Madrid, Spain
    J Neurosci 27:7939-53. 2007
    ..Similar studies are lacking in the trigeminal ganglion (TG)...
  86. ncbi Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanism
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 22:1016-23. 2008
    ..investigated whether under in vivo conditions, inflammation alters the excitability of nociceptive Adelta-trigeminal ganglion (TRG) neurons innervating the facial skin via a cytokine paracrine mechanism...
  87. pmc During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes
    Nicole V Giordani
    Department of Molecular Genetics and Microbiology, Box 100266, University of Florida College of Medicine, Gainesville, FL 32610 0266, USA
    J Virol 82:6056-60. 2008
    ..These results suggest that, for efficient reactivation from latency in rabbits, the LAT is important for increased transcription of lytic genes during latency...
  88. ncbi Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 S W Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Brain Res Brain Res Protoc 15:119-26. 2005
    ..The current paper describes a percutaneous approach for injecting the trigeminal ganglion with an electrical-stimulation needle inserted through the infraorbital foramen, infraorbital canal and ..
  89. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ..the precise distribution of TRPA1, TRPM8, and TRPV1 mRNAs in the rat dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons...
  90. ncbi TRPV1 in migraine pathophysiology
    Jannis E Meents
    Department of Neurology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Trends Mol Med 16:153-9. 2010
    ..We argue that antagonising TRPV1 sensitisation is a promising approach and should receive more attention in future research as well as in the development of anti-migraine drugs...
  91. pmc Hypotonicity modulates tetrodotoxin-sensitive sodium current in trigeminal ganglion neurons
    Lin Li
    Department of Physiology, Nanjing Medical University, Nanjing, PR China
    Mol Pain 7:27. 2011
    ..tested the effect of hypotonicity on tetrodotoxin-sensitive sodium current (TTX-S current) in cultured trigeminal ganglion (TG) neurons. Our data show that after hypotonic treatment, TTX-S current was increased...
  92. pmc Tumor necrosis factor-α increases brain-derived neurotrophic factor expression in trigeminal ganglion neurons in an activity-dependent manner
    E Bałkowiec-Iskra
    Department of Integrative Biosciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA
    Neuroscience 180:322-33. 2011
    ..as migraine or temporo-mandibular disorders, are associated with inflammation within peripheral endings of trigeminal ganglion (TG) sensory neurons...
  93. ncbi Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: a calcium imaging study
    Raya Kushnir
    Laboratory of Experimental Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neuropharmacology 61:739-46. 2011
    ..A similar observation was made in the intact trigeminal ganglion after infra-orbital nerve axotomy...
  94. pmc Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection
    Daniel J J Carr
    Department of Ophthalmology, Dean A McGee Eye Institute, The University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Virol 77:10037-46. 2003
    ..Treatment of HSV-1-infected mice with antibody to CXCL10 significantly reduced CXCL10 levels in the eye and trigeminal ganglion and reduced mononuclear cell infiltration into the corneal stroma...
  95. pmc Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons
    T Liu
    Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2588, USA
    J Virol 75:11178-84. 2001
    ..that CD8(+) T cells could block herpes simplex virus type 1 (HSV-1) reactivation from latency in ex vivo trigeminal ganglion (TG) cultures without destroying the infected neurons...
  96. ncbi The TRPM8 ion channel comprises direct Gq protein-activating capacity
    Katharina Klasen
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Pflugers Arch 463:779-97. 2012
    ..Our observations lead to a view that extends the operational range of the TRPM8 receptor from its function as a pure ion channel to a molecular switch with additional metabotropic capacity...
  97. pmc Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in herpes simplex virus type 1-infected mice
    Sariah J Allen
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Department of Surgery, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Virol 84:12315-24. 2010
    ..In this study, we have shown for the first time that both PD-1 and Tim-3 contribute to T cell exhaustion and an increase of latency in the TG of latently infected mice...
  98. ncbi Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus
    Nikolai E Lazarov
    Department of Anatomy, Faculty of Medicine, Thracian University, 11 Armejska Street, BG 6003 Stara Zagora, Bulgaria
    Prog Neurobiol 66:19-59. 2002
    ..Most of their cell bodies are located in the trigeminal ganglion (TG) but part of them lie in the mesencephalic trigeminal nucleus (MTN)...
  99. pmc Calcitonin gene-related peptide (CGRP) and migraine
    Paul L Durham
    Department of Biology, Missouri State University, 231 Temple Hall, Springfield, MO 65897, USA
    Headache 46:S3-8. 2006
    ....
  100. ncbi Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion
    Celia E Shiau
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 11:269-76. 2008
    ..Here, we show that proper formation of the trigeminal ganglion, the largest of the cranial ganglia, relies on reciprocal interactions between placode and neural crest ..
  101. ncbi Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion
    Steven C Leiser
    Department Neurobiology and Anatomy, Drexel University, School of Biomedical Engineering, 3141 Chestnut St, Philadelphia, PA 19104, USA
    J Neurophysiol 95:3129-45. 2006
    Cells within the trigeminal ganglion (Vg) encode all the information necessary for the rat to differentiate tactile stimuli, yet it is the least-studied component in the rodent trigeminal somatosensory system...

Research Grants63

  1. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
    ..The long-term goal is to identify the regulatory mechanisms to assist in the development of novel therapeutic protocols for better treatments. ..
  2. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..e., trigeminal ganglion) or cornea, both resident and bone marrow-derived cells with a functional type I IFN pathway are required ..
  3. Viral And host mechanisms that tilt the HSV lytic/latent balance
    Donald M Coen; Fiscal Year: 2013
    ..This research wil define basic mechanisms of herpes simplex virus latent infection and new targets for potential drugs to treat the latent infection of these viruses. ..
  4. Estrogen and TMJ Pain
    Phillip R Kramer; Fiscal Year: 2013
    ..We also expect to determine the mechanism by which estrogen modulates expression of these genes in TG cells. ..
  5. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..The goal of this research is to characterize the latency associated transcript gene (LAT) region and investigate the role of LAT during latency in a natural host model system. . ..
  6. THE ROLE FOR THE GPR30 RECEPTOR IN INFLAMMATORY PAIN
    Jill C Fehrenbacher; Fiscal Year: 2010
    ..During inflammation, there is an increase in the amount of estrogens and of these novel receptors in tissues from female rats. We will examine whether these increases contribute to enhanced pain during inflammation in females. ..
  7. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
    ..Our preliminary experiments utilizing RNAi-mediated gene silencing at the trigeminal ganglion, where SGCs surround the cell bodies of primary sensory neurons innervating the face, show that this ..
  8. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    ..This could indicate those HSV-1 proteins that could be potentially exploited in vaccine design to block reactivation when immunological pressure causes loss of immunodominant epitopes. ..
  9. Lipid Mediators in Corneal Nerve Regeneration
    Haydee E P Bazan; Fiscal Year: 2013
    ..and HSV-1 infection relevant to the clinical setting;2) primary and cell line cultures and co-cultures of trigeminal ganglion neurons with corneal epithelial cells and stromal fibroblasts to uncover the molecular mechanisms of ..
  10. Chromatin and Herpes Simplex Virus Latency
    David M Knipe; Fiscal Year: 2013
    ....
  11. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2009
    ..pain sensitivity have been characterized and the gene(s) modulated by these hormonal effects in the joint and trigeminal ganglion identified, targets for pharmaceutical intervention of pain in the TMJ can be pursued.
  12. Genomic systems approach to measure HSV-1-specific T-cell dominance in humans
    David M Koelle; Fiscal Year: 2013
    ..The overall goal of the Project is to identify HSV-1 ORFs for vaccines that stimulate dominant and prevalent CD8 and CD4 epitopes to persons of diverse HLA type that are correlated with mild infection. ..
  13. Lipid kinase regulation of pain signaling and sensitization
    Mark J Zylka; Fiscal Year: 2013
    ..We will be the first to rigorously study the importance of this kinase in the setting of chronic pain. Our preliminary data suggest this lipid kinase is a master regulator of pain signaling and sensitization. ..
  14. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    ..peptide (CGRP) has been implicated in craniofacial pain and headache by virtue of its expression in the trigeminal ganglion and roles in neurogenic inflammation and nociception...
  15. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2013
    ..ganglion cells have marker phenotypes that parallel findings in small to medium sized dorsal root and trigeminal ganglion cells...
  16. Defining Target Contribution to Orofacial Pain by Antisense Oligonucleotides
    Zhigang Luo; Fiscal Year: 2009
    ..Completion of this study will allow us to expand the scope of the parent proposal and accelerate the tempo of scientific research in this under investigated field and the discovery of new drug targets for chronic pain disorders. ..
  17. MODULATION OF MIGRAINE CIRCUIT BY SEROTONIN 1D RECEPTOR-ASSOCIATED PROTEINS
    Yuqing Cao; Fiscal Year: 2013
    ..The serotonin 1D receptor (5-HT1DR) on the central terminals of the trigeminal ganglion (TG) neurons is the prime target of the triptan family of anti-migraine drugs...
  18. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2013
    ..This may lead to the development of new paradigms for immunotherapeutic strategies against ocular herpes. ..
  19. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2011
    ..Specific Aim 1: Characterize rapid effects of estradiol (17_-E2) on BK and PGE2 signaling in trigeminal ganglion. We will determine the concentration- and time- and ligand-dependence of 17_-E2 action and identify the ..
  20. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    ..and DOR systems to inhibit adenylyl cyclase activity and neuropeptide release in primary cultures of rat trigeminal ganglion neurons and in behavioral models of peripheral analgesia...
  21. HSV-1 LAT miRNAs: Neurovirulence, reactivation, mechanism
    Steven L Wechsler; Fiscal Year: 2013
    ..3) Test the hypothesis that the mechanism(s) by which LAT miRNAs influence neurovirulence and/or reactivation is to alter expression of viral genes involved in neurovirulence and reactivation. ..
  22. FUNCTIONAL ANALYSIS OF CALCIUM CHANNEL MUTATIONS IN TRIGEMINAL NOCICEPTION
    Yuqing Cao; Fiscal Year: 2010
    ..that T666M results in a decrease of Ca2+ influx through P/Q- type channels in cultured neurons from trigeminal ganglion as well as cervical dorsal horn...
  23. Developmental pathways in the nervous system
    Eric E Turner; Fiscal Year: 2010
    ..2) Determine the role of the homeodomain factor Hmx1 in the development of the major subdivisions of the trigeminal ganglion, and the gene expression program regulated by Hmx1. 5.
  24. COPAS BIOSORT Worm Sorter
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ..mammalian TRPV4 cation channel directed to the ASH nociceptive head neuron, the cellular equivalent of the trigeminal ganglion of vertebrates, in order to study molecular mechanisms of sensory transduction in response to noxious ..
  25. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2009
    ..In this R21 project, I propose to test the hypothesis that overexpression of CGRP in the mouse trigeminal ganglion will lead to behavioral changes indicative of nociception...
  26. Gender differences in peripheral cannabinoid mediated analgesia
    KATELYN YUEYI NIU; Fiscal Year: 2012
    ..This proposal will serve as a platform on which I can develop into a clinician/scientist. ..
  27. Robo-Slit Signaling in Avian Cornea Innervation
    Tyler Schwend; Fiscal Year: 2013
    ..Understanding the guidance molecules that instruct trigeminal ganglion (TG)-derived axons to enter and branch within the cornea will help to determine if the same guidance ..
  28. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..Collectively, these studies provide a comprehensive evaluation of the hypothesis that activation of estrogen receptors enhances nociceptor function in women. ..
  29. Trigeminal-autonomic relations in ocular homeostasis
    David A Bereiter; Fiscal Year: 2013
    ..a relay in accessory visual pathways, increased PaNS outflow to the eye and transmission through the trigeminal ganglion. To better understand how intraocular trigeminal nerves contribute to PaNS-mediated reflexes we will test ..
  30. Activation of the Trigeminovascular Pathway
    Rami Burstein; Fiscal Year: 2011
    ..mediators to the dura and mast cell degranulation on neuronal activation and sensitization in the trigeminal ganglion and medullary dorsal horn...
  31. HSV-1-specific T-cell responses in human sensory ganglia
    David M Koelle; Fiscal Year: 2010
    ..abstract_text> ..
  32. Dry-responsive corneal afferents, TRPM8, and regulation of tears
    Ian D Meng; Fiscal Year: 2013
    ..Corneal primary afferents will be characterized using in vivo single-unit electrophysiology in the rat trigeminal ganglion. Responses to drying of the ocular surface will be examined, as well as responses evoked by thermal, ..
  33. Role of Host Cell Factors in Herpes Simplex Virus (HSV) Keratitis
    RICHARD M LONGNECKER; Fiscal Year: 2012
    ..In Aim 2, we will determine whether HVEM and/or nectin-1 are necessary for HSV latent infection of the trigeminal ganglion. PUBLIC HEALTH RELEVANCE: Our specific aims are to identify the importance of the cellular receptors, HVEM ..
  34. Gene Therapy for Nerve Injury
    Luc Jasmin; Fiscal Year: 2010
    ..We use gene transfer to increase GABA in neurons of the trigeminal ganglion that supply the sensory innervations of the face and find that this results in analgesia in rats with nerve ..
  35. A novel pathway mediating the development of chronic orofacial neuropathic pain
    Oswald Steward; Fiscal Year: 2013
    ..The final goal of the proposed studies is to identify the peripheral and/or central mechanisms underlying TSP4-mediated transition to chronic pain states after trigeminal nerve injury. ..
  36. HVEM-BTLA system in inflammation
    Carl F Ware; Fiscal Year: 2013
    ..This investigation will provide new insight into the mechanisms of the HVEM cosignaling system in regulating viral pathogenesis. ..
  37. Transient Receptor Potential Vanilloid-1 Sensitization in Inflammation
    JARED MICHAEL SPRAGUE; Fiscal Year: 2013
    ..Finally, high throughput identification screen data will be applied to this model to more closely mimic the inflammatory milieu in vitro and show novel TRPV1-modifying inflammatory compounds. ..
  38. Regulation of Herpes Simplex Type 1 Infection in Corneal Neurons
    Todd P Margolis; Fiscal Year: 2013
    ..The outcome of these studies should generate new insights into the mechanisms regulating HSV infection of neurons;the first step in developing new therapy strategies. ..
  39. MODULATORY ROLE OF GABA AND 5HT RECEPTORS IN MIGRAINE
    F Cutrer; Fiscal Year: 1999
    ..With these proposed experiments we seek to better understand the receptor pharmacology of vascular headaches to thereby establish a more rational basis for new drug discovery in migraine and cluster headache. ..
  40. Genes regulating neurogenesis in the trigeminal placode
    Michael R Stark; Fiscal Year: 2010
    b>Trigeminal ganglion development is a well studied model of vertebrate neurogenesis, where neural crest and placode cells come together to form this group of sensory neurons...
  41. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
    ..In Specific Aim 3, we will examine the effects of ovarian steroids on TMJ and trigeminal responses to TMJ inflammation. These experiments will provide an innovative approach to the mechanism of hormonal regulation of facial pain. ..
  42. Delta-kappa opioid receptor interactions: Ligand-dependent effects
    KELLY ANN BERG; Fiscal Year: 2010
    ..we propose to study the regulation of DOR systems by k opioid antagonists in primary cultures of rat trigeminal ganglion neurons and in behavioral models for analgesia...
  43. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Two hypotheses are proposed: Hypothesis 1) Masticatory muscle inflammation increases the number of trigeminal ganglion (TG) muscle afferent neurons that express: substance P (SP), calcitonin gene-related peptide (CGRP), ..
  44. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
    ..These studies will continue our investigation of herpes simplex virus latency and reactivation and further our understanding of the mechanism of latency in the peripheral nervous system. ..
  45. Peripheral Receptor Mechanisms in Orofacial Muscle Pain
    Jin Y Ro; Fiscal Year: 2013
    ....
  46. Molecular Mechanisms of Axon Branching in Synaptic Development
    Le Ma; Fiscal Year: 2013
    ..the development of stereotypic axonal branches of rodent sensory neurons from the dorsal root ganglion and trigeminal ganglion as models, we have identified an extracellular signaling pathway involving the secreted molecule Slit in ..
  47. Role of lymphoid DCs in HSV-1 latency
    Homayon Ghiasi; Fiscal Year: 2013
    ..The long-term effects of these vaccine strategies will also be characterized to determine whether long-lived CD8+ T cell responses are elicited. ..
  48. Growth Factor-Induced Peripheral Gliogenesis
    Donald Pizzo; Fiscal Year: 2007
    ..Furthermore, the development of a quantitative tumor model allows for the assessment of small molecule therapeutics in a pre-clinical setting. [unreadable] [unreadable]..
  49. Cellular and molecular mechanisms of dental pain
    Man Kyo Chung; Fiscal Year: 2012
    ....
  50. HSV LATENCY AND MECHANISMS OF GENE SILENCING
    Joseph Glorioso; Fiscal Year: 2000
    ..Differences in nucleosome arrangement will be analyzed by a nuclease sensitivity assay. Differences in the CpG sequence methylation will be analyzed. ..
  51. NIH PATHWAY TO INDEPENDENCE APPLICATION (K99/R00)
    BRIAN DAVID RUDD; Fiscal Year: 2010
    ....
  52. The Role of Tooth Mechanoreceptors in Jaw Movement
    Dean Dessem; Fiscal Year: 2006
    ..Three hypotheses are proposed: 1) Trigeminal ganglion jaw muscle and joint primary afferent neurons comprise two general categories with brainstem axonal ..
  53. Regulation of neurotrophin expression in the periphery
    LORI ISAACSON; Fiscal Year: 2009
    ..immunosorbant assay (ELISA), for BDNF and NT-4 protein in the superior cervical ganglion (SCG), the sensory trigeminal ganglion, and their peripheral targets, and the potential for regulation of these proteins by NGF...
  54. Control of trigeminal touch sensory circuit assembly
    Fan Wang; Fiscal Year: 2013
    ..Individual whiskers are innervated by a group of touch sensory neurons located in the trigeminal ganglion, and are mapped onto the brain by the central axons from the same set of trigeminal neurons...
  55. Morphogenesis of the peripheral sensory nervous system
    MARK VOIGT; Fiscal Year: 2009
    ....
  56. Neuronal-Glia Interactions in Trigeminal Ganglia as a Basis for Future Therapy
    Li Yen M Huang; Fiscal Year: 2013
    ....
  57. COCHLEAR BLOOD FLOW AND NEUROPEPTIDES
    Alfred Nuttall; Fiscal Year: 2002
    ..study positive results will demonstrate that endolymphatic hydrops causes a reduction in the stimulated trigeminal ganglion induced CBF change...
  58. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    ....
  59. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..the light and electron microscopic levels in normal rat trigeminal primary afferents (infraorbital nerve, trigeminal ganglion/root entry zone and trigeminal sensory nucleus) and in intrinsic neurons in the trigeminal sensory nucleus...
  60. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
    ..In so doing, we hope to provide initial support for what may be a new long-lasting treatment for trigeminal nerve-related pain. ..
  61. Neonatal Infections and Memory T c ell Repertoire R00
    BRIAN DAVID RUDD; Fiscal Year: 2013
    ..abstract_text> ..
  62. SALIVARY GLANDS AND THEIR INNERVATION IN DIABETES
    JACOB HANKER; Fiscal Year: 1980
    ..The changes observed in their salivary glands and the trigeminal ganglion could be relevant to the increased caries and periodontal involvement...
  63. INNERVATION OF THE MAXILLARY SINUS IN RATS
    KEITH KAJANDER; Fiscal Year: 1993
    ..WGA-HRP is retrogradely transported by primary afferent axons to cell bodies located in the trigeminal ganglion; it then is transported transganglionically to terminals of the primary afferent fibers in the brain stem...