trigeminal ganglion

Summary

Summary: The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.

Top Publications

  1. ncbi P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain
    Masamichi Shinoda
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pain 8:588-97. 2007
  2. ncbi Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain
    Guang Bai
    Department of Biomedical Sciences, Program in Neuroscience, University Maryland Dental School, Baltimore, MD, USA
    Mol Pain 3:15. 2007
  3. ncbi Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy
    Paul L Durham
    Department of Biology, Southwest Missouri State University, MO, USA
    Headache 44:35-42; discussion 42-3. 2004
  4. ncbi Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats
    Dong K Ahn
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea
    Eur J Pain 13:568-75. 2009
  5. ncbi Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion
    Steven C Leiser
    Department Neurobiology and Anatomy, Drexel University, School of Biomedical Engineering, 3141 Chestnut St, Philadelphia, PA 19104, USA
    J Neurophysiol 95:3129-45. 2006
  6. ncbi Calcitonin gene-related peptide (CGRP) and migraine
    Paul L Durham
    Department of Biology, Missouri State University, 231 Temple Hall, Springfield, MO 65897, USA
    Headache 46:S3-8. 2006
  7. ncbi Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Eur J Pain 12:189-95. 2008
  8. ncbi Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion
    Celia E Shiau
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 11:269-76. 2008
  9. ncbi Neuron-glia signaling in trigeminal ganglion: implications for migraine pathology
    Srikanth Thalakoti
    Department of Biology, Missouri State University, Springfield, MO 65897, USA
    Headache 47:1008-23; discussion 24-5. 2007
  10. ncbi Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology
    Alessandro Capuano
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Mol Pain 5:43. 2009

Research Grants

  1. CHEMICAL RESPONSES OF ORAL TRIGEMINAL NERVES
    SIDNEY SIMON; Fiscal Year: 1999
  2. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
  3. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2010
  4. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
  5. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
  6. TOOTH MECHANORECEPTORS AND JAW MOVEMENT
    Dean Dessem; Fiscal Year: 2001
  7. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2010
  8. Developmental Regulation of Corneal Innervation
    THOMAS FRANK LINSENMAYER; Fiscal Year: 2010
  9. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 2007
  10. Growth Factor-Induced Peripheral Gliogenesis
    Donald Pizzo; Fiscal Year: 2007

Detail Information

Publications189 found, 100 shown here

  1. ncbi P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain
    Masamichi Shinoda
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pain 8:588-97. 2007
    ..In the ipsilateral trigeminal ganglion, the number of P2X3-immunoreactive neurons significantly increased in the small cell group...
  2. ncbi Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain
    Guang Bai
    Department of Biomedical Sciences, Program in Neuroscience, University Maryland Dental School, Baltimore, MD, USA
    Mol Pain 3:15. 2007
    ..unilaterally into the rat masseter muscle and quantified changes in neuron-specific mature miRNAs in the trigeminal ganglion (TG)...
  3. ncbi Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy
    Paul L Durham
    Department of Biology, Southwest Missouri State University, MO, USA
    Headache 44:35-42; discussion 42-3. 2004
    ..The results suggest that the effectiveness of botulinum toxin type A in the treatment of migraine may be due, in part, to its ability to repress calcitonin gene-related peptide release from activated sensory neurons...
  4. ncbi Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats
    Dong K Ahn
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea
    Eur J Pain 13:568-75. 2009
    ..first demonstration of prolonged nociceptive behavior in the trigeminal region following compression of the trigeminal ganglion in rats...
  5. ncbi Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion
    Steven C Leiser
    Department Neurobiology and Anatomy, Drexel University, School of Biomedical Engineering, 3141 Chestnut St, Philadelphia, PA 19104, USA
    J Neurophysiol 95:3129-45. 2006
    Cells within the trigeminal ganglion (Vg) encode all the information necessary for the rat to differentiate tactile stimuli, yet it is the least-studied component in the rodent trigeminal somatosensory system...
  6. ncbi Calcitonin gene-related peptide (CGRP) and migraine
    Paul L Durham
    Department of Biology, Missouri State University, 231 Temple Hall, Springfield, MO 65897, USA
    Headache 46:S3-8. 2006
    ....
  7. ncbi Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Eur J Pain 12:189-95. 2008
    ..4 (Kv1.4) of trigeminal ganglion (TRG) neurons innervating TMJ relating allodynia (pain caused by normally innoxious stimulation), by using ..
  8. ncbi Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion
    Celia E Shiau
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 11:269-76. 2008
    ..Here, we show that proper formation of the trigeminal ganglion, the largest of the cranial ganglia, relies on reciprocal interactions between placode and neural crest ..
  9. ncbi Neuron-glia signaling in trigeminal ganglion: implications for migraine pathology
    Srikanth Thalakoti
    Department of Biology, Missouri State University, Springfield, MO 65897, USA
    Headache 47:1008-23; discussion 24-5. 2007
    ..The goal of this study was to investigate neuronal-glial cell signaling in trigeminal ganglia under basal and inflammatory conditions using an in vivo model of trigeminal nerve activation...
  10. ncbi Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology
    Alessandro Capuano
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Mol Pain 5:43. 2009
    ..Thus, in the present study we tested the hypothesis that IL-1beta and NO induce trigeminal satellite cell activation, and that once activated these cells can influence neuronal responses...
  11. ncbi Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons
    T Liu
    Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2588, USA
    J Virol 75:11178-84. 2001
    ..that CD8(+) T cells could block herpes simplex virus type 1 (HSV-1) reactivation from latency in ex vivo trigeminal ganglion (TG) cultures without destroying the infected neurons...
  12. ncbi Capsaicin receptor immunoreactivity in the human trigeminal ganglion
    Mingyan Hou
    Department of Internal Medicine, Lund University Hospital, S-221 85 Lund, Sweden
    Neurosci Lett 330:223-6. 2002
    ..that are VR1 receptor immunoreactive (ir) (171 versus 1038 or 16% of all neuronal cell bodies) in the human trigeminal ganglion (TG). In addition, RT-PCR confirmed the presence of VR1 mRNA in the human TG...
  13. ncbi The functional difference between transient and sustained K+ currents on the action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Brain Res 1152:64-74. 2007
    ..I(A)) and a sustained K(+) current (I(K)) regarding the neuronal function in small-diameter adult rat trigeminal ganglion (TG) neurons, which were insensitive to tetrodotoxin (TTX, 1 microM), we performed two different types of ..
  14. ncbi Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation
    Alfonso Lagares
    Department of Anatomy, Histology, and Neuroscience, Autonoma University of Madrid, Medical School, 28029 Madrid, Spain
    J Neurosci 27:7939-53. 2007
    ..Similar studies are lacking in the trigeminal ganglion (TG)...
  15. ncbi Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion
    Elizabeth Knyihar-Csillik
    Department of Clinical Neurology, University Medical School and Neurology Research Group of the Hungarian Academy of Sciences, Szeged, Hungary
    Exp Neurol 186:242-7. 2004
    Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine...
  16. ncbi Calcium homeostasis in trigeminal ganglion cell bodies
    Tony D Gover
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, MD 21201 1559, United States
    Cell Calcium 41:389-96. 2007
    ..Little is known about Ca2+ homeostasis in trigeminal ganglion neurons (TGNs)...
  17. ncbi Repression of stimulated calcitonin gene-related peptide secretion by topiramate
    Paul L Durham
    Department of Biology, Missouri State University, Springfield, MO, USA
    Headache 46:1291-5. 2006
    ..We propose that topiramate's ability to prevent migraine attacks may involve inhibition of CGRP secretion from trigeminal neurons...
  18. ncbi Enhanced expression of CGRP in rat trigeminal ganglion neurons during cell and organ culture
    Anikó Kuris
    Department of Neurology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Hungary
    Brain Res 1173:6-13. 2007
    The sensory innervation of intracranial vessels originates in the trigeminal ganglion with calcitonin gene-related peptide (CGRP), substance P (SP) and pituitary adenylate cyclase activating peptide (PACAP) as frequent neuronal ..
  19. ncbi Effects of alpha-dendrotoxin on K+ currents and action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    J Pharmacol Exp Ther 314:437-45. 2005
    ..transient current (I(D))] contributes to the modification of neuronal function in small-diameter adult rat trigeminal ganglion (TG) neurons insensitive to 1 microM tetrodotoxin (TTX), we performed two different types of experiments...
  20. ncbi Neonatal anandamide treatment results in prolonged mitochondrial damage in the vanilloid receptor type 1-immunoreactive B-type neurons of the rat trigeminal ganglion
    E Szoke
    Department of Pharmacology and Pharmacotherapy, , Hungary
    Neuroscience 115:805-14. 2002
    ..The results suggest that anandamide, at pharmacologically relevant doses, acts on the VR1 receptor and causes prolonged and selective mitochondrial damage of B-type sensory neurons, as has previously been described for capsaicin...
  21. ncbi Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro
    Kristin Geenen
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Gen Virol 86:1251-60. 2005
    b>Trigeminal ganglion (TG) neurons are important target cells for many alphaherpesviruses, constituting major sites for latency/reactivation events...
  22. ncbi A comparison of propofol and sevoflurane anaesthesia for percutaneous trigeminal ganglion compression
    F Bilotta
    Eur J Anaesthesiol 22:233-5. 2005
  23. ncbi Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons
    Takeshi Tanimoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Tokyo 102 8159, Japan
    Brain Res 1044:262-5. 2005
    ..4 (Kv1.4) or the vanilloid receptor (TRPV1) was examined in adult rat trigeminal ganglion (TG) neurons by using the immunofluorescence method. The small-diameter Kv.1...
  24. ncbi Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 S W Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Brain Res Brain Res Protoc 15:119-26. 2005
    ..The current paper describes a percutaneous approach for injecting the trigeminal ganglion with an electrical-stimulation needle inserted through the infraorbital foramen, infraorbital canal and ..
  25. ncbi Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons
    Takashi Inoue
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Pain 117:193-203. 2005
    ..We measured intracellular calcium in cultured trigeminal ganglion neurons to characterize the cellular mechanisms and chemical structural determinants underlying sensitivity ..
  26. ncbi Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal horn
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159 Japan
    Neuroscience 125:995-1008. 2004
    ....
  27. ncbi Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model
    Jonas Eriksson
    Center for Oral Biology, Novum, Karolinska Institutet, P.O. Box 4064, S-141 04 Huddinge, Sweden
    Pain 119:82-94. 2005
    ..Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel alpha-..
  28. ncbi Activating transcription factor 3 mRNA is upregulated in primary cultures of trigeminal ganglion neurons
    Gregory O Dussor
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Brain Res Mol Brain Res 118:156-9. 2003
    ..In addition, NGF was unable to rescue this injured phenotype. Thus, sensory neurons in culture represent a potential model of injured neurons...
  29. ncbi Expression of inducible nitric oxide synthase in trigeminal ganglion cells during culture
    Inger Jansen-Olesen
    Department of Clinical Experimental Research, Glostrup Hospital, University of Copenhagen, 2600 Glostrup, Denmark
    Basic Clin Pharmacol Toxicol 97:355-63. 2005
    ..It may act as a cellular signalling molecule that is expressed after cell activation...
  30. ncbi The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat
    T J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neuroscience 120:155-62. 2003
    ..address this hypothesis, we evaluated the neuronal distribution of cannabinoid receptor type 1 (CB1) in the trigeminal ganglion (TG) of the adult rat through combined in situ hybridization (ISH) and immunohistochemistry (IHC)...
  31. ncbi Effects of trigeminal ganglion stimulation on unit activity of ventral cochlear nucleus neurons
    S E Shore
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Neuroscience 119:1085-101. 2003
    The trigeminal ganglion sends a projection to the granule and magnocellular regions of the ventral cochlear nucleus (VCN; [J Comp Neurol 419 (2000) 271]), as well as to the cochlea ([Neuroscience 79 (1997) 605; Neuroscience 84 (1998a) ..
  32. ncbi Classification of voltage-dependent Ca2+ channels in trigeminal ganglion neurons from neonatal rats
    Mizuho Ikeda
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 73:1175-87. 2003
    We examined the subtypes and characteristics of the Ca(2+) channel in small (diameter < 30 microm) trigeminal ganglion (TG) neurons from neonatal rats by means of whole cell patch clamp techniques...
  33. ncbi GDNF family ligand receptor components Ret and GFRalpha-1 in the human trigeminal ganglion and sensory nuclei
    Marina Quartu
    Department of Cytomorphology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy
    Brain Res Bull 69:393-403. 2006
    ..Receptor-labeled neurons occur in both trigeminal ganglion and mesencephalic nucleus...
  34. ncbi Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanat
    M Samsam
    , , Facultad de Medicina, Campus Unamuno, c/ Alfonso X El Sabio s/n, 37007, Salamanca, Spain
    J Chem Neuroanat 21:161-9. 2001
    Primary trigeminal neurons of the trigeminal ganglion (TG) innervate major parts of the face and head, including the dura...
  35. ncbi Tumor necrosis factor-α increases brain-derived neurotrophic factor expression in trigeminal ganglion neurons in an activity-dependent manner
    E Bałkowiec-Iskra
    Department of Integrative Biosciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA
    Neuroscience 180:322-33. 2011
    ..as migraine or temporo-mandibular disorders, are associated with inflammation within peripheral endings of trigeminal ganglion (TG) sensory neurons...
  36. ncbi Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells
    Yoshio Yamamoto
    Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Neurosci Lett 454:129-33. 2009
    ..Mean sizes of TREK-1, TREK-2 and TRAAK immunoreactive trigeminal ganglion neurons were 447+/-185, 445+/-23 and 492+/-12 mm2, respectively...
  37. ncbi Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide
    L Edvinsson
    Department of Internal Medicine, Lund University Hospital, Sweden
    J Auton Nerv Syst 70:15-22. 1998
    ..In the trigeminal ganglion of the cat, a moderate number of NOS immunoreactive nerve cell bodies was seen, of which the major part ..
  38. ncbi High prevalence of co-infections with bovine herpesvirus 1 and 5 found in cattle in southern Brazil
    F S Campos
    Microbiology Department, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, Rio Grande do Sul RS, Brazil
    Vet Microbiol 139:67-73. 2009
    ..1% with BoHV-5 and 75.9% with both BoHV-1 and BoHV-5. This is the first time that such a high frequency of co-infection of BoHV-1 and BoHV-5 in bovines has been demonstrated...
  39. ncbi Osmolality-induced tuning of action potentials in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Neurosci Lett 452:79-83. 2009
    The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment...
  40. ncbi Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 24:72-82. 2010
    ..aim of the present study was to investigate whether GDNF acutely modulates the excitability of adult rat trigeminal ganglion (TRG) neurons that innervate the facial skin by using perforated-patch clamping, retrograde-labeling and ..
  41. ncbi Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia
    Mirjam Eberhardt
    Institute of Physiology and Experimental Pathophysiology, Erlangen, Germany
    Neuropeptides 43:483-9. 2009
    ..The present data suggest that prolonged increase in NO levels facilitates stimulated CGRP release from trigeminal ganglion neurons...
  42. ncbi The roles of I(D), I(A) and I(K) in the electrophysiological functions of small diameter rat trigeminal ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Curr Mol Pharmacol 3:30-6. 2010
    ..inactivating transient K+ current (I(A)) and dominant sustained K+ current (I(K)), in small-diameter rat trigeminal ganglion (TG) neurons...
  43. ncbi Alternation of gene expression in trigeminal ganglion neurons following complete Freund's adjuvant or capsaicin injection into the rat face
    Masayo Okumura
    Institute for Oral Science, Matsumoto Dental University, 1780, Hiro oka, Gobara, Shiojiri, Nagano 399 0781, Japan
    J Mol Neurosci 42:200-9. 2010
    The hyperexcitability of trigeminal ganglion (TG) neurons following inflammation or C-fiber stimulation is known to be involved in a variety of changes in gene expression in TG neurons, resulting in pain abnormalities in orofacial ..
  44. ncbi Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
    S Eftekhari
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    Neuroscience 169:683-96. 2010
    ..calcitonin receptor-like receptor (CLR) and receptor activity modifying protein (RAMP) 1 in the human trigeminal ganglion using immunohistochemistry and compare with that of rat...
  45. ncbi p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
    A M Davies
    School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
    Neuron 11:565-74. 1993
    ..These findings indicate that p75 enhances the sensitivity of NGF-dependent cutaneous sensory neurons to NGF and may explain, at least in part, the cutaneous sensory abnormalities of mice homozygous for the p75 mutation...
  46. ncbi Delaying the expression of herpes simplex virus type 1 glycoprotein B (gB) to a true late gene alters neurovirulence and inhibits the gB-CD8+ T-cell response in the trigeminal ganglion
    Srividya Ramachandran
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Virol 84:8811-20. 2010
    ..These data have implications for designing better immunogens for vaccines to prevent HSV-1 reactivation...
  47. ncbi NGF mRNA expression in developing cutaneous epithelium related to innervation density
    S Harper
    Department of Anatomy, St George s Hospital Medical School, Tooting, London, UK
    Development 110:515-9. 1990
    ..the concentration of NGF mRNA in the epithelia of the maxillary, mandibular and ophthalmic territories of trigeminal ganglion in the embryonic mouse...
  48. ncbi Ascending multisynaptic pathways from the trigeminal ganglion to the anterior cingulate cortex
    Koichi Iwata
    Department of Physiology, Nihon University School of Dentistry, 1 8 13 Kandasurugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Exp Neurol 227:69-78. 2011
    By means of retrograde transneuronal transport of rabies virus, ascending multisynaptic pathways from the trigeminal ganglion (TG) to the anterior cingulate cortex (ACC) were identified in the rat...
  49. ncbi X-knife stereotactic radiosurgery on the trigeminal ganglion to treat trigeminal neuralgia: a preliminary study
    M J Chen
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, People s Republic of China
    Minim Invasive Neurosurg 53:223-8. 2010
    ..The purpose of this article was to evaluate the efficacy of and complications associated with X-knife stereotactic radiosurgery on the trigeminal ganglion (TG) for TN.
  50. ncbi Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, No 13, Hangkong Road, Wuhan 430030, PR China
    Neurosci Res 64:199-207. 2009
    ..Whether VGSCs can be modulated by changes in osmolality in trigeminal ganglion (TG) neurons remains unknown...
  51. ncbi The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons
    L Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, No 13, Hangkong Road, Wuhan, PR China
    Neuroscience 154:482-95. 2008
    ..patch clamp techniques, we explore how hypo- and hypertonicity modulate VGPCs in cultured rat and mouse trigeminal ganglion (TG) neurons...
  52. ncbi Trigeminal ganglion innervates the auditory brainstem
    S E Shore
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Comp Neurol 419:271-85. 2000
    A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made ..
  53. ncbi Changes in osmolality modulate voltage-gated calcium channels in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Brain Res 1208:56-66. 2008
    ..For this reason by using whole-cell patch clamp techniques in rat and mouse trigeminal ganglion (TG) neurons we tested the effects of hypo- and hypertonicity on VGCCs...
  54. ncbi Developmental changes in the expression of Shaker- and Shab-related K(+) channels in neurons of the rat trigeminal ganglion
    G Seifert
    Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Brain Res Mol Brain Res 74:55-68. 1999
    We have investigated properties of voltage-gated K(+) channels in neurons of the pre- and postnatal rat trigeminal ganglion (TG)...
  55. ncbi Excitability of small-diameter trigeminal ganglion neurons by 5-HT is mediated by enhancement of the tetrodotoxin-resistant sodium current due to the activation of 5-HT(4) receptors and/or by the inhibition of the transient potassium current
    Y Tsutsui
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neuroscience 157:683-96. 2008
    ..significantly on the modification of the tetrodotoxin-resistant sodium current (I(NaR)) in small-sized rat trigeminal ganglion (TG) neurons and whether the inhibition of the transient K(+) current (I(A)) contributed to the ..
  56. ncbi Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers
    Milena De Felice
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Brain 133:2475-88. 2010
    ..repeated or sustained triptan administration for several days can elicit persistent neural adaptations in trigeminal ganglion cells innervating the dura, prominently characterized by increased labelling of neuronal profiles for ..
  57. ncbi Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanism
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 22:1016-23. 2008
    ..investigated whether under in vivo conditions, inflammation alters the excitability of nociceptive Adelta-trigeminal ganglion (TRG) neurons innervating the facial skin via a cytokine paracrine mechanism...
  58. ncbi Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling
    Yan Xiao
    Department of Biochemistry and Molecular Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, 950 West Walnut Street, Indianapolis, Indiana, 46202, USA
    Mol Pain 4:12. 2008
    ..the importance of voltage-dependent calcium channels in controlling release of glutamate and CGRP from trigeminal ganglion neurons isolated from male and female rats and grown in culture...
  59. ncbi Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons
    Manuela Simonetti
    Neurobiology Sector and Italian Institute of Technology Unit, International School for Advanced Studies SISSA, 34014 Trieste, Italy
    J Biol Chem 283:18743-52. 2008
    ..responsible for CGRP-evoked long lasting alterations in P2X(3) receptors, we used as a model mouse trigeminal ganglion neurons in culture...
  60. ncbi Activation of interleukin-1beta receptor suppresses the voltage-gated potassium currents in the small-diameter trigeminal ganglion neurons following peripheral inflammation
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, Fujimi cho, Chiyoda ku, Tokyo, Japan
    Pain 139:594-602. 2008
    The glial cytokine, interleukin-1beta (IL-1beta), potentiates the excitability of nociceptive trigeminal ganglion (TRG) neurons via membrane depolarization following peripheral inflammation...
  61. ncbi CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways
    C V Vause
    Department of Biology, Missouri State University, Springfield, Missouri 65897, USA
    J Neurochem 110:811-21. 2009
    ..Recently, we have shown that CGRP can stimulate the synthesis and release of nitric oxide (NO) from trigeminal ganglion glial cells...
  62. ncbi The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons
    Ditsa Levanon
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    EMBO J 21:3454-63. 2002
    ..The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans...
  63. ncbi Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, USA
    Br J Pharmacol 141:1118-30. 2004
    ..actions of cannabinoid-vanilloid agonists on sensory neurons, we examined the effects of these compounds on trigeminal ganglion (TG) neurons in vitro. 2. AEA (EC(50)=11...
  64. ncbi Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors
    Amol M Patwardhan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 25:8825-32. 2005
    ..These findings indicate that exposure to certain inflammatory mediators rapidly alters the signaling properties and neuronal localization of DOR, possibly contributing to peripheral opioid analgesia...
  65. ncbi The beta-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane
    Su San Mok
    Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 96:53-64. 2006
    ..An inhibitor of ERK1/2 phosphorylation enhanced the effect of Abeta on cell adhesion. The studies suggest that Abeta can decrease VSMC viability by disrupting VSMC-extracellular matrix (ECM) adhesion...
  66. ncbi Primary sensory neurons containing choline acetyltransferase of the peripheral type in the rat trigeminal ganglion and their relation to neuropeptides-, calbindin- and nitric oxide synthase-containing cells
    Osamu Yasuhara
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Brain Res 1141:92-8. 2007
    ..was observed in a rather uniform pattern in about half of all trigeminal neurons throughout the trigeminal ganglion. The majority of pChAT-positive neurons had small to medium-sized cell bodies...
  67. ncbi Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons
    Theodore J Price
    The University of Texas Health Science Center at San Antonio, Department of Endodontics, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Neurosci Lett 389:94-8. 2005
    ..Herein, we have explored a possible interaction of CaMKIIalpha activity with the TRPV1 receptor in rat trigeminal ganglion (TG) neurons in vitro...
  68. ncbi Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression
    R Ambalavanar
    Department of Biomedical Sciences and Program in Neuroscience, University of Maryland, 650 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 149:650-9. 2007
    ..which are implicated in transformations following acidification of hindlimb muscles, were found on trigeminal ganglion muscle afferent neurons via combined neuronal tracing and immunocytochemistry...
  69. ncbi Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, BK21, School of Dentistry, Kyungpook National University, Daegu 700 412, Korea
    J Comp Neurol 506:627-39. 2008
    ..immunofluorescence and electron microscopy to characterize the P2X(3)-immunopositive (+) neurons in the trigeminal ganglion and describe the distribution and synaptic organization of their central terminals within the rat TBSN, ..
  70. ncbi Delta-opioid receptor-immunoreactive neurons in the rat cranial sensory ganglia
    H Ichikawa
    Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1043:225-30. 2005
    ..The present study suggests that DOR-IR neurons may be associated with nociceptive and/or chemoreceptive function in the cranial sensory ganglia...
  71. ncbi Trigeminal nociceptors express prostaglandin receptors
    A M Patwardhan
    Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Dent Res 87:262-6. 2008
    ..Analysis of these data, collectively, supports the hypothesis that prostaglandins regulate trigeminal TRPV(1) nociceptors via activation of the EP2 and EP3 receptors...
  72. ncbi Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury
    C Grelik
    Department of Pharmacology and Therapeutics, McGill University, 3655 Prom. Sir-William-Osler, Montreal, Quebec, Canada H3G 1Y6
    Eur J Neurosci 21:2475-87. 2005
    ..There was no sympathetic fibre sprouting in the trigeminal ganglion following CCI...
  73. ncbi A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons
    Theodore J Price
    Department of Endodontics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Neuropharmacology 49:25-39. 2005
    ..be important for anandamide (AEA)- and N-arachidonoyl-dopamine (NADA)-evoked CGRP release from cultured trigeminal ganglion (TG) neurons...
  74. ncbi Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential
    Jianghui Meng
    International Centre for Neurotherapeutics, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Cell Sci 120:2864-74. 2007
    ..Such use of particular Sbr isoform(s) by different neurons raises the functional implications for other cells previously unrecognised...
  75. ncbi Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat
    Toshihiko Shimizu
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo, 160 8582, Japan
    Brain Res 1173:84-91. 2007
    ..6% of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- ..
  76. ncbi Electrophysiological properties and chemosensitivity of acutely dissociated trigeminal somata innervating the cornea
    T H Veiga Moreira
    Department of Pharmacology and Experimental Therapeutics, University of Maryland, School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 148:766-74. 2007
    Adult rat sensory trigeminal ganglion neurons innervating the cornea (cTGNs) were isolated and identified following retrograde dye labeling with FM1-43...
  77. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ..the precise distribution of TRPA1, TRPM8, and TRPV1 mRNAs in the rat dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons...
  78. ncbi Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons
    Lieju Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 95:1478-90. 2006
    ..In summary, the potentiation of INa through chronic IL-1beta signaling in nociceptive sensory neurons may be a critical component of inflammatory-associated hyperalgesia...
  79. ncbi Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist
    Ranjinidevi Ambalavanar
    Department of Biomedical Sciences, University of Maryland, Baltimore, 21201, USA
    Pain 120:53-68. 2006
    ..Elevated levels of calcitonin gene-related peptide (CGRP) within the trigeminal ganglion temporally correlated with this mechanical allodynia...
  80. ncbi Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    J Pain 8:263-72. 2007
    ..Taken together, the present findings dictate prudence when extrapolating experimental conclusions about the neurochemical classification of neurons between sensory ganglia or between species, including humans...
  81. ncbi Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons
    Ilya Buldyrev
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurochem 99:1338-50. 2006
    ..show that CGRP is coexpressed with brain-derived neurotrophic factor (BDNF) in a large subset of adult rat trigeminal ganglion neurons in vivo...
  82. ncbi Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats
    Kenjiro Nagamine
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pain 7:659-70. 2006
    ..Characterizations of these molecular systems which mediate pain perception are important to develop novel clinical tools for promoting relief of oral cancer pain...
  83. ncbi Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons
    Jialie Luo
    Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China
    Brain Res 1115:9-15. 2006
    In the present study, ATP-activated currents (I(ATP)s) recorded from rat trigeminal ganglion (TG) neurons using whole-cell patch clamp technique are classified into three types (F, I and S) based on the characteristics of their ..
  84. ncbi Herpes simplex virus type-1 latency-associated transcript-induced immunoreactivity of substance P in trigeminal neurons is reversed by bone morphogenetic protein-7
    Mohamed A Hamza
    Departments of Pharmacology and Toxicology, University at Buffalo, SUNY, Buffalo, NY 14214, United States
    Neurosci Lett 413:31-5. 2007
    ..Treatment with BMP7 reversed the effects of LAT on substance P expression in trigeminal neurons. Our data show for the first time that LAT increases substance P expression in trigeminal neurons and BMP7 can reverse these effects of LAT...
  85. ncbi Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia
    Tobias Derfuss
    Institute of Clinical Neuroimmunology, University Clinic, Munich, Germany
    Brain Pathol 17:389-98. 2007
    ..Thus, HSV-1 IE genes are expressed in human TG and the infiltrating T-cells bear several characteristics that suggest viral antigenic stimulation...
  86. ncbi Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone
    Hu Wang
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201-1586, USA
    J Comp Neurol 498:390-402. 2006
    ..b>Trigeminal ganglion tissue sections were processed for single or double immunohistochemistry...
  87. ncbi The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons
    T J Price
    Departments of Endodontics and Pharmacology, The University of Texas Health Science Center at San Antonio, TX, USA
    Neuroscience 141:2107-16. 2006
    ..Based on these findings, we propose that stau2 and FMRP proteins are attractive candidates to subserve RNA transport in sensory neurons, linking somal transcriptional events to axonal translation...
  88. ncbi Effect of carbon dioxide on calcitonin gene-related peptide secretion from trigeminal neurons
    Carrie Vause
    Missouri State University Biology, Department of Biology, Springfield, MO 65897, USA
    Headache 47:1385-97. 2007
    ..The goal of this study was to determine whether the physiological effects of carbon dioxide (CO(2)) involve regulation of CGRP secretion from trigeminal sensory neurons...
  89. ncbi Nitric oxide regulation of calcitonin gene-related peptide gene expression in rat trigeminal ganglia neurons
    Jamie Bellamy
    Department of Biology, 225 Temple Hall, Missouri State University, Springfield, MO 65897, USA
    Eur J Neurosci 23:2057-66. 2006
    ..In summary, our results provide new insight into the cellular mechanisms by which nitric oxide induces CGRP synthesis and secretion from trigeminal neurons...
  90. ncbi Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5'-fluorouridine into nascent RNA
    I Casafont
    Department of Anatomy and Cell Biology and Biomedicine Unit, CSIC, University of Cantabria, Avd. Cardenal Herrera Oria, s/n, 39011 Santander, Spain
    Neuroscience 140:453-62. 2006
    ..5'-Fluorouridine incorporation in animal models provides a useful tool to investigate the organization of gene expression in mammalian neurons in both normal physiology and experimental pathology systems...
  91. ncbi Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia
    Nathaniel A Jeske
    Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    J Neurochem 97:13-21. 2006
    ..Taken together, these data demonstrate that EP24.15/16 modulate intracellular, peptidergic signaling cascades through B2R in a physiologically relevant nociceptive system...
  92. ncbi Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    Zheng Gen Piao
    Department of Physiology, College of Dentistry and Dental Research Institute, Seoul National University, Seoul 110 749, Republic of Korea
    Pain 121:219-31. 2006
    ..There was no significant loss of trigeminal ganglion neurons by 28 days following IAMNT, suggesting that degenerative changes in central terminals of primary ..
  93. ncbi Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons
    Yuzo Murata
    Division of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Nabeshima 5 1 1, Saga 849 8501, Japan
    Brain Res 1085:87-94. 2006
    ..For observing corneal neuronal elements in the trigeminal ganglion (TG) and in the medulla oblongata, retrograde and anterograde cholera toxin subunit B (CTB) tracing methods ..
  94. ncbi Brain-derived neurotrophic factor-immunoreactive primary sensory neurons in the rat trigeminal ganglion and trigeminal sensory nuclei
    H Ichikawa
    Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 1081:113-8. 2006
    Immunohistochemistry for brain-derived neurotrophic factor (BDNF) was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 46% of TG neurons...
  95. ncbi Two alphaherpesvirus latency-associated gene products influence calcitonin gene-related peptide levels in rat trigeminal neurons
    Mohamed A Hamza
    Department of Pharmacology and Toxicology, SUNY, Buffalo, NY 14214, USA
    Neurobiol Dis 25:553-60. 2007
    ..In contrast, increased release of CGRP in the presence of IE63 protein may contribute to the neuralgias associated with VZV infection...
  96. ncbi The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis
    E Ensor
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 276:5204-12. 2001
    ..Specifically, overexpression of BRN-3A in cultured trigeminal ganglion or dorsal root ganglion sensory neurons enhanced their survival following the withdrawal of nerve growth ..
  97. ncbi A model experimental system for monitoring changes in sensory neuron phenotype evoked by tooth injury
    Yan Pan
    Department of Anatomy, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 29216, USA
    J Neurosci Methods 126:99-109. 2003
    ..Thus, labeling of trigeminal neurons via dentinal tubules provides the basis for a useful model for precisely assessing properties of pulpal afferents in both quiescent and activated states...
  98. ncbi The herpes simplex virus type 1 ICP0 promoter is activated by viral reactivation stimuli in trigeminal ganglia neurons of transgenic mice
    C M Loiacono
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri 65211, USA
    J Neurovirol 9:336-45. 2003
    ..It further suggests the possibility that activation of ICP0 gene expression by neuronal transcription factors may be important in reactivation of HSV-1 in neurons...
  99. ncbi Kv1.2-immunoreactive primary sensory neurons in the rat trigeminal ganglion
    Hiroyuki Ichikawa
    Department of Oral Anatomy and Function, and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Japan
    Brain Res 974:222-7. 2003
    Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons...
  100. ncbi Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons
    L Liu
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 89:1387-401. 2003
    ..In capsaicin-sensitive (CS) rat trigeminal ganglion (TG) neurons, capsaicin inhibited I(A) currents in a dose-dependent manner...
  101. ncbi The difference of osteocalcin-immunoreactive neurons in the rat dorsal root and trigeminal ganglia: co-expression with nociceptive transducers and central projection
    Hiroyuki Ichikawa
    Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 958:459-62. 2002
    ..The present study suggests that OC-ir TG nociceptors send their unmyelinated axons to the superficial laminae of the MDH...

Research Grants84

  1. CHEMICAL RESPONSES OF ORAL TRIGEMINAL NERVES
    SIDNEY SIMON; Fiscal Year: 1999
    ..single unit recordings from rat lingual and chorda tympani nerves, and patch-clamp recordings from rat trigeminal ganglion neurons in response to chemical irritants...
  2. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Two hypotheses are proposed: Hypothesis 1) Masticatory muscle inflammation increases the number of trigeminal ganglion (TG) muscle afferent neurons that express: substance P (SP), calcitonin gene-related peptide (CGRP), ..
  3. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2010
    ....
  4. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
    ..In Specific Aim 3, we will examine the effects of ovarian steroids on TMJ and trigeminal responses to TMJ inflammation. These experiments will provide an innovative approach to the mechanism of hormonal regulation of facial pain. ..
  5. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
    ..These studies will continue our investigation of herpes simplex virus latency and reactivation and further our understanding of the mechanism of latency in the peripheral nervous system. ..
  6. TOOTH MECHANORECEPTORS AND JAW MOVEMENT
    Dean Dessem; Fiscal Year: 2001
    ..Three hypotheses are proposed: 1) Sensory feedback from trigeminal ganglion masticatory muscle afferents reaches trigeminal motoneurons via disynaptic and trisynaptic neuronal ..
  7. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2010
    ..ganglion cells have marker phenotypes that parallel findings in small to medium sized dorsal root and trigeminal ganglion cells...
  8. Developmental Regulation of Corneal Innervation
    THOMAS FRANK LINSENMAYER; Fiscal Year: 2010
    ..Corneal nerves originate chiefly from the ophthalmic branch of the trigeminal ganglion (TGG) and are largely sensory, responding to noxious mechanical, thermal and chemical stimuli by ..
  9. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 2007
    ..Yet such studies are essential for a full understanding of the sense of taste, which motivates our food choices and thereby mediates healthy or unhealthy diet patterns. ..
  10. Growth Factor-Induced Peripheral Gliogenesis
    Donald Pizzo; Fiscal Year: 2007
    ..Furthermore, the development of a quantitative tumor model allows for the assessment of small molecule therapeutics in a pre-clinical setting. ..
  11. The Role of Tooth Mechanoreceptors in Jaw Movement
    Dean Dessem; Fiscal Year: 2006
    ..Three hypotheses are proposed: 1) Trigeminal ganglion jaw muscle and joint primary afferent neurons comprise two general categories with brainstem axonal ..
  12. Regulation of opioid receptor function in trigeminal ganglion
    William Clarke; Fiscal Year: 2009
    ..and DOR systems to inhibit adenylyl cyclase activity and neuropeptide release in primary cultures of rat trigeminal ganglion neurons and in behavioral models of peripheral analgesia...
  13. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2010
    ..The work has important implications in vaccine design aimed to prevent the triggering infections. ..
  14. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    ..peptide (CGRP) has been implicated in craniofacial pain and headache by virtue of its expression in the trigeminal ganglion and roles in neurogenic inflammation and nociception...
  15. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2010
    ..Our preliminary experiments utilizing RNAi-mediated gene silencing at the trigeminal ganglion, where SGCs surround the cell bodies of primary sensory neurons innervating the face, show that this ..
  16. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2011
    ..Our preliminary experiments utilizing RNAi-mediated gene silencing at the trigeminal ganglion, where SGCs surround the cell bodies of primary sensory neurons innervating the face, show that this ..
  17. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2010
    ..Specific Aim 1: Characterize rapid effects of estradiol (17_-E2) on BK and PGE2 signaling in trigeminal ganglion. We will determine the concentration- and time- and ligand-dependence of 17_-E2 action and identify the ..
  18. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    ....
  19. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2007
    ..pain sensitivity have been characterized and the gene(s) modulated by these hormonal effects in the joint and trigeminal ganglion identified, targets for pharmaceutical intervention of pain in the TMJ can be pursued.
  20. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2010
    ....
  21. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..the light and electron microscopic levels in normal rat trigeminal primary afferents (infraorbital nerve, trigeminal ganglion/root entry zone and trigeminal sensory nucleus) and in intrinsic neurons in the trigeminal sensory nucleus...
  22. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2009
    ..pain sensitivity have been characterized and the gene(s) modulated by these hormonal effects in the joint and trigeminal ganglion identified, targets for pharmaceutical intervention of pain in the TMJ can be pursued.