trigeminal ganglion

Summary

Summary: The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.

Top Publications

  1. doi Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
  2. pmc Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, Japan
    Mol Pain 7:5. 2011
  3. doi TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
  4. pmc A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro
    Andrea S Bertke
    Department of Ophthalmology, University of California, San Francisco, Medical Sciences Building, s 310, 513 Parnassus Ave, Box 0412, San Francisco, CA 94143 0412, USA
    J Virol 85:6669-77. 2011
  5. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
  6. ncbi Vertebrate cranial placodes I. Embryonic induction
    C V Baker
    Division of Biology 139 74, California Institute of Technology, Pasadena, California, 91125, USA
    Dev Biol 232:1-61. 2001
  7. doi Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells
    Yoshio Yamamoto
    Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Neurosci Lett 454:129-33. 2009
  8. pmc Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
    Lawrence T Feldman
    Department of Microbiology and Immunology, University of California Medical Center, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 99:978-83. 2002
  9. doi Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype
    Monique van Velzen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 183:2456-61. 2009
  10. ncbi Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation
    S E Shore
    Kresge Hearing Research Institute and Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Eur J Neurosci 21:3334-48. 2005

Research Grants

  1. CHEMICAL RESPONSES OF ORAL TRIGEMINAL NERVES
    SIDNEY SIMON; Fiscal Year: 1999
  2. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
  3. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2010
  4. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
  5. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
  6. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2010
  7. TOOTH MECHANORECEPTORS AND JAW MOVEMENT
    Dean Dessem; Fiscal Year: 2001
  8. Developmental Regulation of Corneal Innervation
    THOMAS FRANK LINSENMAYER; Fiscal Year: 2010
  9. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 2007
  10. Growth Factor-Induced Peripheral Gliogenesis
    Donald Pizzo; Fiscal Year: 2007

Detail Information

Publications236 found, 100 shown here

  1. doi Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
    Within the trigeminal ganglion, crosstalk between neurons and satellite glial cells (SGCs) contributes to neuronal sensitization and transduction of painful stimuli, including migraine pain, at least partly through activation of ..
  2. pmc Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, Japan
    Mol Pain 7:5. 2011
    ..pain animal models, particularly the relationship between changes in Kv channels and the excitability of trigeminal ganglion (TRG) neurons...
  3. doi TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
    ..These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat...
  4. pmc A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro
    Andrea S Bertke
    Department of Ophthalmology, University of California, San Francisco, Medical Sciences Building, s 310, 513 Parnassus Ave, Box 0412, San Francisco, CA 94143 0412, USA
    J Virol 85:6669-77. 2011
    ..the establishment of HSV latency in specific subtypes of neurons, cultured dissociated adult murine trigeminal ganglion (TG) neurons were assessed for relative permissiveness for productive infection...
  5. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors...
  6. ncbi Vertebrate cranial placodes I. Embryonic induction
    C V Baker
    Division of Biology 139 74, California Institute of Technology, Pasadena, California, 91125, USA
    Dev Biol 232:1-61. 2001
    ....
  7. doi Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells
    Yoshio Yamamoto
    Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Neurosci Lett 454:129-33. 2009
    ..Mean sizes of TREK-1, TREK-2 and TRAAK immunoreactive trigeminal ganglion neurons were 447+/-185, 445+/-23 and 492+/-12 mm2, respectively...
  8. pmc Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
    Lawrence T Feldman
    Department of Microbiology and Immunology, University of California Medical Center, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 99:978-83. 2002
    ..In the absence of detectable infectious virus in these ganglia, we propose the term "spontaneous molecular reactivation" to describe this ongoing process...
  9. doi Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype
    Monique van Velzen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 183:2456-61. 2009
    ....
  10. ncbi Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation
    S E Shore
    Kresge Hearing Research Institute and Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Eur J Neurosci 21:3334-48. 2005
    ..We investigated trigeminal system influences on guinea pig DCN cells by stimulating the trigeminal ganglion while recording spontaneous and sound-driven activity from DCN neurons...
  11. pmc Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache
    Jin Yan
    University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
    Pain 152:106-13. 2011
    ..These data provide a cellular mechanism by which decreased pH in the meninges following ischemic or inflammatory events directly excites afferent pain-sensing neurons potentially contributing to migraine headache...
  12. pmc TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation
    Phillip Edward Kunkler
    The Department of Biochemistry and Molecular Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pain 152:38-44. 2011
    ..We suggest that these events contribute to headache associated with environmental irritants...
  13. pmc Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons
    L Tarsa
    Department of Integrative Biosciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA
    Neuroscience 167:1205-15. 2010
    Nociceptive pathways with first-order neurons located in the trigeminal ganglion (TG) provide sensory innervation to the head, and are responsible for a number of common chronic pain conditions, including migraines, temporomandibular ..
  14. doi Differential Changes in TRPV1 expression after trigeminal sensory nerve injury
    Hyun Yeong Kim
    Department of Physiology and Program in Molecular and Cellular Neuroscience, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
    J Pain 9:280-8. 2008
    ..In these animals, we found that neuronal loss of trigeminal ganglion (TG) was not correlated with pain hypersensitivity...
  15. pmc Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions
    Mei Xu
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Pain 9:1036-48. 2008
    ..Nerve injury marker ATF3 was markedly increased in ipsilateral trigeminal ganglion neurons at 8 days after pIONL...
  16. pmc Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain
    Guang Bai
    Department of Biomedical Sciences, Program in Neuroscience, University Maryland Dental School, Baltimore, MD, USA
    Mol Pain 3:15. 2007
    ..unilaterally into the rat masseter muscle and quantified changes in neuron-specific mature miRNAs in the trigeminal ganglion (TG)...
  17. pmc Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Virol 83:2246-54. 2009
    ....
  18. pmc Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons
    V Staikopoulos
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Neuroscience 144:208-16. 2007
    ..examine the distribution of P2X2 and P2X3 receptors in primary afferent cell bodies in the rat trigeminal ganglion, including those innervating the dura...
  19. ncbi Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia
    K Tsuzuki
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pain 91:351-60. 2001
    ..peroneal nerves and the transection of the infraorbital nerve, and observed dorsal root ganglion (DRG) and trigeminal ganglion neurons, respectively...
  20. pmc Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice
    Megumi Aita
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Mol Pain 6:8. 2010
    ..BrdU) as a mitotic marker, we assessed cell proliferation in three different areas of the trigeminal afferent pathway: trigeminal nucleus principalis (Vp), trigeminal root entry zone (TREZ), and trigeminal ganglion (TG).
  21. ncbi Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Cell Calcium 43:576-90. 2008
    ..At this exposure time, P2Y receptors responses in satellite glia were instead upregulated, suggesting a complex modulation of P2 receptors in pain signaling...
  22. ncbi Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy
    Paul L Durham
    Department of Biology, Southwest Missouri State University, MO, USA
    Headache 44:35-42; discussion 42-3. 2004
    ..To determine the effect of botulinum toxin type A on calcitonin gene-related peptide secretion from cultured trigeminal ganglia neurons...
  23. ncbi Neutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons
    Rashid Giniatullin
    Neurobiology Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 27:8190-201. 2007
    ..is proposed as a novel analgesic approach, its consequences on nociceptive purinergic P2X receptors of trigeminal ganglion neurons remain unknown...
  24. doi Botulinum toxin type a (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction
    Y Kitamura
    Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neuroscience 159:1422-9. 2009
    ..Thus, we monitored the secretory activity of acutely dissociated trigeminal ganglion (TRG) neurons from naïve and IoNC rats by measuring the fluorescence intensity of the membrane-uptake ..
  25. pmc Herpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis
    Francisco J Branco
    Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:9019-25. 2005
    ..Furthermore, no HSV strain 17-infected trigeminal ganglion neurons were apoptotic, but 0.087% of 17deltaSty and 0.98% of 17 N/H-infected neurons were apoptotic...
  26. pmc Can satellite glial cells be therapeutic targets for pain control?
    Luc Jasmin
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Neuron Glia Biol 6:63-71. 2010
    ..Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain...
  27. pmc TRPA1 acts as a cold sensor in vitro and in vivo
    Yuji Karashima
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1273-8. 2009
    ..Second, we identify and characterize a specific subset of cold-sensitive trigeminal ganglion neurons that is absent in TRPA1-deficient mice...
  28. doi Direct activation of transient receptor potential V1 by nickel ions
    Matthias Luebbert
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Pflugers Arch 459:737-50. 2010
    ..are able to induce non-specific cation currents in a capsaicin-sensitive population of cultured mouse trigeminal ganglion neurons...
  29. ncbi Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model
    Jonas Eriksson
    Center for Oral Biology, Novum, Karolinska Institutet, P O Box 4064, S 141 04 Huddinge, Sweden
    Pain 119:82-94. 2005
    ..Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel alpha-..
  30. pmc A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
    Yunfu Sun
    Department of Medicine, University of California San Diego, La Jolla, California 93093, USA
    Nat Neurosci 11:1283-93. 2008
    ..Together these results establish a central role for Islet1 in the transition from sensory neurogenesis to subtype specification...
  31. pmc Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine
    B Fioretti
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, 35121 Padova, Italy
    J Physiol 589:5879-95. 2011
    ..Here we studied the calcium currents and excitability properties of two subpopulations of small-diameter trigeminal ganglion (TG) neurons from adult wild-type (WT) and R192Q FHM1 knockin (KI) mice: capsaicin-sensitive neurons ..
  32. ncbi Trigeminal ganglion innervates the auditory brainstem
    S E Shore
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Comp Neurol 419:271-85. 2000
    A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made ..
  33. doi Selectively targeting pain in the trigeminal system
    Hyun Yeong Kim
    National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110 749, Republic of Korea
    Pain 150:29-40. 2010
    ..QX-314 alone failed to block voltage-gated sodium channel currents (I(Na)) and action potentials (APs) in trigeminal ganglion (TG) neurons...
  34. pmc Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons
    Jeffrey J Iliff
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurochem 115:1530-42. 2010
    ..We previously described the expression of cytochrome P450-2J epoxygenase in rat trigeminal ganglion neurons and that EETs signaling is involved in cerebrovascular dilation resulting from perivascular nerve ..
  35. pmc Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus
    Giovanni Villa
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pain 6:89. 2010
    ....
  36. pmc Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions
    Xi Chun Zhang
    Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Pain 152:140-9. 2011
    ....
  37. doi The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system
    Romina Nassini
    Department of Preclinical and Clinical Pharmacology and Headache Centre, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Brain 135:376-90. 2012
    ..selectively stimulated transient receptor potential ankyrin 1-expressing HEK293 cells and rat trigeminal ganglion neurons, but not untransfected cells or neurons in the presence of the selective transient receptor ..
  38. ncbi Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury
    James E Biggs
    Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, South Yorkshire S10 2TA, UK
    Eur J Pain 11:192-201. 2007
    ..tracer, fluorogold, was injected into the damaged nerve to identify associated cell bodies in the trigeminal ganglion. Three further ferrets, receiving only tracer injection, served as uninjured controls...
  39. doi Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line
    Eva Szoke
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Eur J Pharmacol 628:67-74. 2010
    ..Evidence for a supporting role of cholesterol, sphingomyelin and gangliosides were obtained both in native and TRPV1-transfected cells. Differential modulation of responses to capsaicin and RTX was often observed...
  40. ncbi Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat
    Juan Miguel Jimenez-Andrade
    Neurosystems Center, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, United States
    Neurosci Lett 405:62-7. 2006
    ..To begin to define the type and location of sensory neurons most impacted by paclitaxel, we examined rat trigeminal ganglion, thoracic and lumbar dorsal root ganglion (DRG) 10 days following intravenous infusion of clinically ..
  41. ncbi Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior
    R Ambalavanar
    Department of Biomedical Sciences and Program in Neuroscience, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 143:875-84. 2006
    ..A rapid and significant increase in CGRP mRNA occurred in the mandibular division (V3) of the ipsilateral trigeminal ganglion at 30 minutes, 4 and 24 h after the injection of complete Freund's adjuvant as an inflammatory agent into ..
  42. ncbi Peripheral targeting of the trigeminal ganglion via the infraorbital foramen as a therapeutic strategy
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 S W Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Brain Res Brain Res Protoc 15:119-26. 2005
    ..The current paper describes a percutaneous approach for injecting the trigeminal ganglion with an electrical-stimulation needle inserted through the infraorbital foramen, infraorbital canal and ..
  43. ncbi Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation
    Alfonso Lagares
    Department of Anatomy, Histology, and Neuroscience, Autonoma University of Madrid, Medical School, 28029 Madrid, Spain
    J Neurosci 27:7939-53. 2007
    ..Similar studies are lacking in the trigeminal ganglion (TG)...
  44. pmc Estrogen and inflammation increase the excitability of rat temporomandibular joint afferent neurons
    Natasha M Flake
    Department of Biomedical Sciences, Dental School, University of Maryland, 666 W Baltimore St, Rm 5 A 12, Baltimore, MD 21201, USA
    J Neurophysiol 93:1585-97. 2005
    ....
  45. ncbi Chronic electrostimulation of the trigeminal ganglion in trigeminal neuropathy: current state and future prospects
    J H Mehrkens
    Neurochirurgische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Acta Neurochir Suppl 97:91-7. 2007
    Over two decades ago, the electrostimulation of the trigeminal ganglion (TGES) was established as a treatment option for patients with trigeminopathic pain due to a (iatrogenic) lesion of the trigeminal nerve, on whom the other ..
  46. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ..the precise distribution of TRPA1, TRPM8, and TRPV1 mRNAs in the rat dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons...
  47. pmc Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection
    Daniel J J Carr
    Department of Ophthalmology, Dean A McGee Eye Institute, The University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA
    J Virol 77:10037-46. 2003
    ..Treatment of HSV-1-infected mice with antibody to CXCL10 significantly reduced CXCL10 levels in the eye and trigeminal ganglion and reduced mononuclear cell infiltration into the corneal stroma...
  48. ncbi Calcium homeostasis in trigeminal ganglion cell bodies
    Tony D Gover
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, MD 21201 1559, United States
    Cell Calcium 41:389-96. 2007
    ..Little is known about Ca2+ homeostasis in trigeminal ganglion neurons (TGNs)...
  49. ncbi Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus
    Nikolai E Lazarov
    Department of Anatomy, Faculty of Medicine, Thracian University, 11 Armejska Street, BG 6003 Stara Zagora, Bulgaria
    Prog Neurobiol 66:19-59. 2002
    ..Most of their cell bodies are located in the trigeminal ganglion (TG) but part of them lie in the mesencephalic trigeminal nucleus (MTN)...
  50. pmc During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes
    Nicole V Giordani
    Department of Molecular Genetics and Microbiology, Box 100266, University of Florida College of Medicine, Gainesville, FL 32610 0266, USA
    J Virol 82:6056-60. 2008
    ..These results suggest that, for efficient reactivation from latency in rabbits, the LAT is important for increased transcription of lytic genes during latency...
  51. pmc Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons
    T Liu
    Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2588, USA
    J Virol 75:11178-84. 2001
    ..that CD8(+) T cells could block herpes simplex virus type 1 (HSV-1) reactivation from latency in ex vivo trigeminal ganglion (TG) cultures without destroying the infected neurons...
  52. doi Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanism
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 22:1016-23. 2008
    ..investigated whether under in vivo conditions, inflammation alters the excitability of nociceptive Adelta-trigeminal ganglion (TRG) neurons innervating the facial skin via a cytokine paracrine mechanism...
  53. doi TRPV1 in migraine pathophysiology
    Jannis E Meents
    Department of Neurology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Trends Mol Med 16:153-9. 2010
    ..We argue that antagonising TRPV1 sensitisation is a promising approach and should receive more attention in future research as well as in the development of anti-migraine drugs...
  54. pmc Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in herpes simplex virus type 1-infected mice
    Sariah J Allen
    Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Department of Surgery, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Virol 84:12315-24. 2010
    ..In this study, we have shown for the first time that both PD-1 and Tim-3 contribute to T cell exhaustion and an increase of latency in the TG of latently infected mice...
  55. doi The TRPM8 ion channel comprises direct Gq protein-activating capacity
    Katharina Klasen
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Pflugers Arch 463:779-97. 2012
    ..Our observations lead to a view that extends the operational range of the TRPM8 receptor from its function as a pure ion channel to a molecular switch with additional metabotropic capacity...
  56. doi Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, Kyungpook National University, Daegu, Korea
    J Comp Neurol 518:687-98. 2010
    ..To address this issue, we characterized the TRPA1-positive (+) neurons in the trigeminal ganglion (TG) and investigated the distribution of TRPA1(+) afferent fibers and their synaptic connectivity within ..
  57. pmc Tumor necrosis factor-α increases brain-derived neurotrophic factor expression in trigeminal ganglion neurons in an activity-dependent manner
    E Bałkowiec-Iskra
    Department of Integrative Biosciences, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA
    Neuroscience 180:322-33. 2011
    ..as migraine or temporo-mandibular disorders, are associated with inflammation within peripheral endings of trigeminal ganglion (TG) sensory neurons...
  58. pmc Hypotonicity modulates tetrodotoxin-sensitive sodium current in trigeminal ganglion neurons
    Lin Li
    Department of Physiology, Nanjing Medical University, Nanjing, PR China
    Mol Pain 7:27. 2011
    ..tested the effect of hypotonicity on tetrodotoxin-sensitive sodium current (TTX-S current) in cultured trigeminal ganglion (TG) neurons. Our data show that after hypotonic treatment, TTX-S current was increased...
  59. pmc Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats
    Ayano Katagiri
    Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan
    Mol Pain 8:23. 2012
    ..stimulation of the tongue, P2Y12R and glial fibrillary acidic protein (GFAP) immunohistochemistries in the trigeminal ganglion (TG) in a rat model of unilateral lingual nerve crush (LNC) to evaluate role of P2Y12R in SGC in lingual ..
  60. doi Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: a calcium imaging study
    Raya Kushnir
    Laboratory of Experimental Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Neuropharmacology 61:739-46. 2011
    ..A similar observation was made in the intact trigeminal ganglion after infra-orbital nerve axotomy...
  61. pmc Calcitonin gene-related peptide (CGRP) and migraine
    Paul L Durham
    Department of Biology, Missouri State University, 231 Temple Hall, Springfield, MO 65897, USA
    Headache 46:S3-8. 2006
    ....
  62. ncbi Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion
    Steven C Leiser
    Department Neurobiology and Anatomy, Drexel University, School of Biomedical Engineering, 3141 Chestnut St, Philadelphia, PA 19104, USA
    J Neurophysiol 95:3129-45. 2006
    Cells within the trigeminal ganglion (Vg) encode all the information necessary for the rat to differentiate tactile stimuli, yet it is the least-studied component in the rodent trigeminal somatosensory system...
  63. ncbi Temporomandibular joint inflammation decreases the voltage-gated K+ channel subtype 1.4-immunoreactivity of trigeminal ganglion neurons in rats
    Mamoru Takeda
    Department of Physiology, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Eur J Pain 12:189-95. 2008
    ..4 (Kv1.4) of trigeminal ganglion (TRG) neurons innervating TMJ relating allodynia (pain caused by normally innoxious stimulation), by using ..
  64. doi Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion
    Celia E Shiau
    Division of Biology 139 74, California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 11:269-76. 2008
    ..Here, we show that proper formation of the trigeminal ganglion, the largest of the cranial ganglia, relies on reciprocal interactions between placode and neural crest ..
  65. doi Compression of the trigeminal ganglion produces prolonged nociceptive behavior in rats
    Dong K Ahn
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea
    Eur J Pain 13:568-75. 2009
    ..first demonstration of prolonged nociceptive behavior in the trigeminal region following compression of the trigeminal ganglion in rats...
  66. pmc Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0524, USA
    J Virol 75:6660-75. 2001
    ..The number of latent sites established in trigeminal ganglion (TG) neurons was determined using a single-cell quantitative PCR assay for the viral genome on purified TG ..
  67. doi Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distribution
    Jochen K Lennerz
    Institute of Physiology and Pathophysiology, University of Erlangen Nurnberg, Erlangen, Germany
    J Comp Neurol 507:1277-99. 2008
    ..In the trigeminal ganglion, besides Schwann and satellite cells, CLR- and RAMP1-ir was found in subpopulations of CGRP-ir neurons ..
  68. pmc Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells
    Robert J Danaher
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Dentistry and College of Medicine, Lexington, KY 40536 0297, USA
    J Neurovirol 11:306-17. 2005
    ..e., recrudescence)...
  69. doi Fine-grained fate maps for the ophthalmic and maxillomandibular trigeminal placodes in the chick embryo
    Hong Xu
    University of Cambridge, Department of Physiology, Development and Neuroscience, Anatomy Building, Downing Street, Cambridge CB2 3DY, UK
    Dev Biol 317:174-86. 2008
    ..placodes, which give rise to cutaneous sensory neurons in the ophthalmic and maxillomandibular lobes of the trigeminal ganglion. We used focal DiI and DiO labelling to produce eight detailed fate-maps of chick embryonic head ectoderm ..
  70. pmc Neuron-glia signaling in trigeminal ganglion: implications for migraine pathology
    Srikanth Thalakoti
    Department of Biology, Missouri State University, Springfield, MO 65897, USA
    Headache 47:1008-23; discussion 24-5. 2007
    ..The goal of this study was to investigate neuronal-glial cell signaling in trigeminal ganglia under basal and inflammatory conditions using an in vivo model of trigeminal nerve activation...
  71. pmc Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology
    Alessandro Capuano
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Mol Pain 5:43. 2009
    ..Thus, in the present study we tested the hypothesis that IL-1beta and NO induce trigeminal satellite cell activation, and that once activated these cells can influence neuronal responses...
  72. ncbi NGF mRNA expression in developing cutaneous epithelium related to innervation density
    S Harper
    Department of Anatomy, St George s Hospital Medical School, Tooting, London, UK
    Development 110:515-9. 1990
    ..the concentration of NGF mRNA in the epithelia of the maxillary, mandibular and ophthalmic territories of trigeminal ganglion in the embryonic mouse...
  73. pmc Delaying the expression of herpes simplex virus type 1 glycoprotein B (gB) to a true late gene alters neurovirulence and inhibits the gB-CD8+ T-cell response in the trigeminal ganglion
    Srividya Ramachandran
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Virol 84:8811-20. 2010
    ..These data have implications for designing better immunogens for vaccines to prevent HSV-1 reactivation...
  74. ncbi p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
    A M Davies
    School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland
    Neuron 11:565-74. 1993
    ..These findings indicate that p75 enhances the sensitivity of NGF-dependent cutaneous sensory neurons to NGF and may explain, at least in part, the cutaneous sensory abnormalities of mice homozygous for the p75 mutation...
  75. ncbi Developmental changes in the expression of Shaker- and Shab-related K(+) channels in neurons of the rat trigeminal ganglion
    G Seifert
    Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Brain Res Mol Brain Res 74:55-68. 1999
    We have investigated properties of voltage-gated K(+) channels in neurons of the pre- and postnatal rat trigeminal ganglion (TG)...
  76. doi Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
    S Eftekhari
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    Neuroscience 169:683-96. 2010
    ..calcitonin receptor-like receptor (CLR) and receptor activity modifying protein (RAMP) 1 in the human trigeminal ganglion using immunohistochemistry and compare with that of rat...
  77. doi Alternation of gene expression in trigeminal ganglion neurons following complete Freund's adjuvant or capsaicin injection into the rat face
    Masayo Okumura
    Institute for Oral Science, Matsumoto Dental University, 1780, Hiro oka, Gobara, Shiojiri, Nagano 399 0781, Japan
    J Mol Neurosci 42:200-9. 2010
    The hyperexcitability of trigeminal ganglion (TG) neurons following inflammation or C-fiber stimulation is known to be involved in a variety of changes in gene expression in TG neurons, resulting in pain abnormalities in orofacial ..
  78. ncbi Effects of alpha-dendrotoxin on K+ currents and action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    J Pharmacol Exp Ther 314:437-45. 2005
    ..transient current (I(D))] contributes to the modification of neuronal function in small-diameter adult rat trigeminal ganglion (TG) neurons insensitive to 1 microM tetrodotoxin (TTX), we performed two different types of experiments...
  79. ncbi Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro
    Kristin Geenen
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Gen Virol 86:1251-60. 2005
    b>Trigeminal ganglion (TG) neurons are important target cells for many alphaherpesviruses, constituting major sites for latency/reactivation events...
  80. ncbi Repression of stimulated calcitonin gene-related peptide secretion by topiramate
    Paul L Durham
    Department of Biology, Missouri State University, Springfield, MO, USA
    Headache 46:1291-5. 2006
    ..The goal of the proposed research was to determine the effect of topiramate on basal and stimulated release of calcitonin gene-related peptide (CGRP) from trigeminal ganglia neurons...
  81. ncbi GDNF family ligand receptor components Ret and GFRalpha-1 in the human trigeminal ganglion and sensory nuclei
    Marina Quartu
    Department of Cytomorphology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy
    Brain Res Bull 69:393-403. 2006
    ..Receptor-labeled neurons occur in both trigeminal ganglion and mesencephalic nucleus...
  82. doi X-knife stereotactic radiosurgery on the trigeminal ganglion to treat trigeminal neuralgia: a preliminary study
    M J Chen
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, People s Republic of China
    Minim Invasive Neurosurg 53:223-8. 2010
    ..The purpose of this article was to evaluate the efficacy of and complications associated with X-knife stereotactic radiosurgery on the trigeminal ganglion (TG) for TN.
  83. ncbi Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons
    Takashi Inoue
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Pain 117:193-203. 2005
    ..We measured intracellular calcium in cultured trigeminal ganglion neurons to characterize the cellular mechanisms and chemical structural determinants underlying sensitivity ..
  84. doi Ascending multisynaptic pathways from the trigeminal ganglion to the anterior cingulate cortex
    Koichi Iwata
    Department of Physiology, Nihon University School of Dentistry, 1 8 13 Kandasurugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Exp Neurol 227:69-78. 2011
    By means of retrograde transneuronal transport of rabies virus, ascending multisynaptic pathways from the trigeminal ganglion (TG) to the anterior cingulate cortex (ACC) were identified in the rat...
  85. ncbi The functional difference between transient and sustained K+ currents on the action potentials in tetrodotoxin-resistant adult rat trigeminal ganglion neurons
    Shinki Yoshida
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Brain Res 1152:64-74. 2007
    ..I(A)) and a sustained K(+) current (I(K)) regarding the neuronal function in small-diameter adult rat trigeminal ganglion (TG) neurons, which were insensitive to tetrodotoxin (TTX, 1 microM), we performed two different types of ..
  86. pmc Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers
    Milena De Felice
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Brain 133:2475-88. 2010
    ..repeated or sustained triptan administration for several days can elicit persistent neural adaptations in trigeminal ganglion cells innervating the dura, prominently characterized by increased labelling of neuronal profiles for ..
  87. ncbi Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons
    Takeshi Tanimoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Tokyo 102 8159, Japan
    Brain Res 1044:262-5. 2005
    ..4 (Kv1.4) or the vanilloid receptor (TRPV1) was examined in adult rat trigeminal ganglion (TG) neurons by using the immunofluorescence method. The small-diameter Kv.1...
  88. ncbi A comparison of propofol and sevoflurane anaesthesia for percutaneous trigeminal ganglion compression
    F Bilotta
    Eur J Anaesthesiol 22:233-5. 2005
  89. ncbi Expression of inducible nitric oxide synthase in trigeminal ganglion cells during culture
    Inger Jansen-Olesen
    Department of Clinical Experimental Research, Glostrup Hospital, University of Copenhagen, 2600 Glostrup, Denmark
    Basic Clin Pharmacol Toxicol 97:355-63. 2005
    ..It may act as a cellular signalling molecule that is expressed after cell activation...
  90. ncbi Opioidergic modulation of excitability of rat trigeminal root ganglion neuron projections to the superficial layer of cervical dorsal horn
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo, 102 8159 Japan
    Neuroscience 125:995-1008. 2004
    ....
  91. ncbi Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide
    L Edvinsson
    Department of Internal Medicine, Lund University Hospital, Sweden
    J Auton Nerv Syst 70:15-22. 1998
    ..In the trigeminal ganglion of the cat, a moderate number of NOS immunoreactive nerve cell bodies was seen, of which the major part ..
  92. ncbi Effects of trigeminal ganglion stimulation on unit activity of ventral cochlear nucleus neurons
    S E Shore
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109, USA
    Neuroscience 119:1085-101. 2003
    The trigeminal ganglion sends a projection to the granule and magnocellular regions of the ventral cochlear nucleus (VCN; [J Comp Neurol 419 (2000) 271]), as well as to the cochlea ([Neuroscience 79 (1997) 605; Neuroscience 84 (1998a) ..
  93. ncbi Classification of voltage-dependent Ca2+ channels in trigeminal ganglion neurons from neonatal rats
    Mizuho Ikeda
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 73:1175-87. 2003
    We examined the subtypes and characteristics of the Ca(2+) channel in small (diameter < 30 microm) trigeminal ganglion (TG) neurons from neonatal rats by means of whole cell patch clamp techniques...
  94. pmc Changes in osmolality modulate voltage-gated calcium channels in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Brain Res 1208:56-66. 2008
    ..For this reason by using whole-cell patch clamp techniques in rat and mouse trigeminal ganglion (TG) neurons we tested the effects of hypo- and hypertonicity on VGCCs...
  95. doi High prevalence of co-infections with bovine herpesvirus 1 and 5 found in cattle in southern Brazil
    F S Campos
    Microbiology Department, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, Rio Grande do Sul RS, Brazil
    Vet Microbiol 139:67-73. 2009
    ..1% with BoHV-5 and 75.9% with both BoHV-1 and BoHV-5. This is the first time that such a high frequency of co-infection of BoHV-1 and BoHV-5 in bovines has been demonstrated...
  96. pmc Osmolality-induced tuning of action potentials in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Neurosci Lett 452:79-83. 2009
    The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment...
  97. doi Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 24:72-82. 2010
    ..aim of the present study was to investigate whether GDNF acutely modulates the excitability of adult rat trigeminal ganglion (TRG) neurons that innervate the facial skin by using perforated-patch clamping, retrograde-labeling and ..
  98. ncbi The roles of I(D), I(A) and I(K) in the electrophysiological functions of small diameter rat trigeminal ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan
    Curr Mol Pharmacol 3:30-6. 2010
    ..inactivating transient K+ current (I(A)) and dominant sustained K+ current (I(K)), in small-diameter rat trigeminal ganglion (TG) neurons...
  99. pmc The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons
    L Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, No 13, Hangkong Road, Wuhan, PR China
    Neuroscience 154:482-95. 2008
    ..patch clamp techniques, we explore how hypo- and hypertonicity modulate VGPCs in cultured rat and mouse trigeminal ganglion (TG) neurons...
  100. ncbi Neonatal anandamide treatment results in prolonged mitochondrial damage in the vanilloid receptor type 1-immunoreactive B-type neurons of the rat trigeminal ganglion
    E Szoke
    Department of Pharmacology and Pharmacotherapy, Pecs, Hungary
    Neuroscience 115:805-14. 2002
    ..The results suggest that anandamide, at pharmacologically relevant doses, acts on the VR1 receptor and causes prolonged and selective mitochondrial damage of B-type sensory neurons, as has previously been described for capsaicin...
  101. ncbi Capsaicin receptor immunoreactivity in the human trigeminal ganglion
    Mingyan Hou
    Department of Internal Medicine, Lund University Hospital, S 221 85 Lund, Sweden
    Neurosci Lett 330:223-6. 2002
    ..that are VR1 receptor immunoreactive (ir) (171 versus 1038 or 16% of all neuronal cell bodies) in the human trigeminal ganglion (TG). In addition, RT-PCR confirmed the presence of VR1 mRNA in the human TG...

Research Grants85

  1. CHEMICAL RESPONSES OF ORAL TRIGEMINAL NERVES
    SIDNEY SIMON; Fiscal Year: 1999
    ..single unit recordings from rat lingual and chorda tympani nerves, and patch-clamp recordings from rat trigeminal ganglion neurons in response to chemical irritants...
  2. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Two hypotheses are proposed: Hypothesis 1) Masticatory muscle inflammation increases the number of trigeminal ganglion (TG) muscle afferent neurons that express: substance P (SP), calcitonin gene-related peptide (CGRP), ..
  3. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2010
    ....
  4. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
    ..In Specific Aim 3, we will examine the effects of ovarian steroids on TMJ and trigeminal responses to TMJ inflammation. These experiments will provide an innovative approach to the mechanism of hormonal regulation of facial pain. ..
  5. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
    ..These studies will continue our investigation of herpes simplex virus latency and reactivation and further our understanding of the mechanism of latency in the peripheral nervous system. ..
  6. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2010
    ..ganglion cells have marker phenotypes that parallel findings in small to medium sized dorsal root and trigeminal ganglion cells...
  7. TOOTH MECHANORECEPTORS AND JAW MOVEMENT
    Dean Dessem; Fiscal Year: 2001
    ..Three hypotheses are proposed: 1) Sensory feedback from trigeminal ganglion masticatory muscle afferents reaches trigeminal motoneurons via disynaptic and trisynaptic neuronal ..
  8. Developmental Regulation of Corneal Innervation
    THOMAS FRANK LINSENMAYER; Fiscal Year: 2010
    ..Corneal nerves originate chiefly from the ophthalmic branch of the trigeminal ganglion (TGG) and are largely sensory, responding to noxious mechanical, thermal and chemical stimuli by ..
  9. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 2007
    ..Yet such studies are essential for a full understanding of the sense of taste, which motivates our food choices and thereby mediates healthy or unhealthy diet patterns. ..
  10. Growth Factor-Induced Peripheral Gliogenesis
    Donald Pizzo; Fiscal Year: 2007
    ..Furthermore, the development of a quantitative tumor model allows for the assessment of small molecule therapeutics in a pre-clinical setting. ..
  11. The Role of Tooth Mechanoreceptors in Jaw Movement
    Dean Dessem; Fiscal Year: 2006
    ..Three hypotheses are proposed: 1) Trigeminal ganglion jaw muscle and joint primary afferent neurons comprise two general categories with brainstem axonal ..
  12. Regulation of opioid receptor function in trigeminal ganglion
    William Clarke; Fiscal Year: 2009
    ..and DOR systems to inhibit adenylyl cyclase activity and neuropeptide release in primary cultures of rat trigeminal ganglion neurons and in behavioral models of peripheral analgesia...
  13. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2010
    ..The work has important implications in vaccine design aimed to prevent the triggering infections. ..
  14. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    ..peptide (CGRP) has been implicated in craniofacial pain and headache by virtue of its expression in the trigeminal ganglion and roles in neurogenic inflammation and nociception...
  15. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2010
    ..Our preliminary experiments utilizing RNAi-mediated gene silencing at the trigeminal ganglion, where SGCs surround the cell bodies of primary sensory neurons innervating the face, show that this ..
  16. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2011
    ..Our preliminary experiments utilizing RNAi-mediated gene silencing at the trigeminal ganglion, where SGCs surround the cell bodies of primary sensory neurons innervating the face, show that this ..
  17. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2010
    ..Specific Aim 1: Characterize rapid effects of estradiol (17_-E2) on BK and PGE2 signaling in trigeminal ganglion. We will determine the concentration- and time- and ligand-dependence of 17_-E2 action and identify the ..
  18. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    ....
  19. Therapeutic Ocular HSV Vaccine in HLA Transgenic Rabbits
    Lbachir BenMohamed; Fiscal Year: 2010
    ....
  20. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2009
    ..pain sensitivity have been characterized and the gene(s) modulated by these hormonal effects in the joint and trigeminal ganglion identified, targets for pharmaceutical intervention of pain in the TMJ can be pursued.
  21. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2007
    ..pain sensitivity have been characterized and the gene(s) modulated by these hormonal effects in the joint and trigeminal ganglion identified, targets for pharmaceutical intervention of pain in the TMJ can be pursued.
  22. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..the light and electron microscopic levels in normal rat trigeminal primary afferents (infraorbital nerve, trigeminal ganglion/root entry zone and trigeminal sensory nucleus) and in intrinsic neurons in the trigeminal sensory nucleus...