nodose ganglion

Summary

Summary: The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.

Top Publications

  1. ncbi Neuronal NADPH-d/NOS expression in the nodose ganglion of severe hypoxic rats with or without mild hypoxic preconditioning
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Chem Neuroanat 29:149-56. 2005
  2. ncbi Patch clamp electrophysiology in nodose ganglia of adult rat
    B Y Li
    Biomedical Engineering Program, Purdue School of Engineering and Technology, Indiana University, Room SL 174, 723 West Michigan Street, Indianapolis, IN 46202, USA
    J Neurosci Methods 115:157-67. 2002
  3. pmc Upregulation of brain-derived neurotrophic factor expression in nodose ganglia and the lower brainstem of hypertensive rats
    Anke Vermehren-Schmaedick
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 91:220-9. 2013
  4. ncbi Comparisons of somatic action potentials from dispersed and intact rat nodose ganglia using patch-clamp technique
    Bai Yan Li
    Experimental and Computational Neurobiology Laboratory, Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis 46202, USA
    Acta Pharmacol Sin 23:481-9. 2002
  5. pmc Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons
    Patricia A Glazebrook
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44109, USA
    J Physiol 541:467-82. 2002
  6. ncbi Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007
  7. ncbi Characteristics of ATP-activated current in nodose ganglion neurons of rats
    Yan Tan
    Department of Neurology, The Affiliated Hospital of Guangdong Medical College, No 57, People s Avenue South, Xiashan, Zhanjiang 524001, China
    Neurosci Lett 459:25-9. 2009
  8. ncbi Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells
    Atsushi Nakagawa
    Department of Internal Medicine, Kanazawa Medical University, Daigaku 1 1, Uchinada 920 0293, Japan
    Auton Neurosci 110:36-43. 2004
  9. ncbi Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion
    Toru Hosoi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Auton Neurosci 120:104-7. 2005
  10. ncbi Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers
    Thanh N Doan
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Neurosci 24:3335-43. 2004

Detail Information

Publications238 found, 100 shown here

  1. ncbi Neuronal NADPH-d/NOS expression in the nodose ganglion of severe hypoxic rats with or without mild hypoxic preconditioning
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Chem Neuroanat 29:149-56. 2005
    ..hypoxic preconditioning (MHPC)-induced NOS expression would attenuate the neuropathological changes in the nodose ganglion (NG) of severe hypoxic exposure (SHE) rats...
  2. ncbi Patch clamp electrophysiology in nodose ganglia of adult rat
    B Y Li
    Biomedical Engineering Program, Purdue School of Engineering and Technology, Indiana University, Room SL 174, 723 West Michigan Street, Indianapolis, IN 46202, USA
    J Neurosci Methods 115:157-67. 2002
    ..Here, we present a methodology for preparing nodose ganglion from adult rat (250-400 g) for study using the patch clamp technique...
  3. pmc Upregulation of brain-derived neurotrophic factor expression in nodose ganglia and the lower brainstem of hypertensive rats
    Anke Vermehren-Schmaedick
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 91:220-9. 2013
    ..Our previous studies show that brain-derived neurotrophic factor (BDNF) is abundantly expressed by rat nodose ganglion (NG) neurons, including baroreceptor afferents and their central terminals in the medial NTS...
  4. ncbi Comparisons of somatic action potentials from dispersed and intact rat nodose ganglia using patch-clamp technique
    Bai Yan Li
    Experimental and Computational Neurobiology Laboratory, Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis 46202, USA
    Acta Pharmacol Sin 23:481-9. 2002
    ..To differentiate the electrophysiological characteristics of somatic action potentials (AP) from isolated Neo and Juv nodose sensory neurons (NSN) and those from slices of intact Juv and adult rat nodose ganglia...
  5. pmc Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons
    Patricia A Glazebrook
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44109, USA
    J Physiol 541:467-82. 2002
    ....
  6. ncbi Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007
    ..These data are consistent with an important component of neural mediation of GLP-1 action...
  7. ncbi Characteristics of ATP-activated current in nodose ganglion neurons of rats
    Yan Tan
    Department of Neurology, The Affiliated Hospital of Guangdong Medical College, No 57, People s Avenue South, Xiashan, Zhanjiang 524001, China
    Neurosci Lett 459:25-9. 2009
    The characteristics of ATP-activated currents (I(ATP)) in rat nodose ganglion (NG) neurons have not been fully clarified...
  8. ncbi Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells
    Atsushi Nakagawa
    Department of Internal Medicine, Kanazawa Medical University, Daigaku 1 1, Uchinada 920 0293, Japan
    Auton Neurosci 110:36-43. 2004
    ..derived from those electrophysiological observations, receptor gene expressions of GLP-1 and GIP in the rat nodose ganglion were examined by means of reverse transcriptase-mediated polymerase chain reaction (RT-PCR) and Northern blot ..
  9. ncbi Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion
    Toru Hosoi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Auton Neurosci 120:104-7. 2005
    ..In the present study, we found that TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested that LPS could activate afferent vagus nerve at the level of nodose ganglion, which ..
  10. ncbi Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers
    Thanh N Doan
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Neurosci 24:3335-43. 2004
    ..At the sensory receptor terminal, CsCl decreased the threshold pressure for initiation of mechanoreceptor discharge. Therefore, elimination of the I(H) increases excitability of both the soma and the peripheral sensory terminals...
  11. ncbi Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents
    John H Schild
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Auton Neurosci 172:4-12. 2012
    ..But the complement of VGC in C-type neurons provides far greater capacity for neuromodulation of cell excitability than can be obtained from A-type baroreceptors...
  12. pmc Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia
    Bai Yan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Neurosci Methods 164:75-85. 2007
    ..An intact rat nodose ganglion preparation was used to randomly sample neurons (n=76) using the patch clamp technique...
  13. pmc Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat
    Guangfan Zhang
    Department of Physiology, University of Kentucky Medical Center, 800 Rose Street Lexington, KY 40536 0298, USA
    J Physiol 586:5771-86. 2008
    ..In conclusion, allergen-induced airway inflammation clearly elevated capsaicin sensitivity in myelinated pulmonary afferents, which probably resulted from an increased expression of TRPV1 in these sensory nerves...
  14. pmc Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs
    Kevin Kwong
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Physiol 586:1321-36. 2008
    ..we obtained data supporting the hypothesis that the TTX-R sodium currents are similarly distributed between nodose ganglion A-fibres and C-fibres innervating the lung...
  15. pmc Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia
    Gintautas Grabauskas
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    J Physiol 588:617-32. 2010
    ..The results also show that PIP(2) can determine the excitability of glucose-excited neurons...
  16. pmc Subtype identification in acutely dissociated rat nodose ganglion neurons based on morphologic parameters
    Xiao Long Lu
    Department of Pharmacology, Harbin Medical University, Harbin, China
    Int J Biol Sci 9:716-27. 2013
    ..the sliced ganglion preparation have provided valuable insights into the electrophysiological properties of nodose ganglion neuron subtypes, detailed characterization of their electrical phenotypes will require measurements in ..
  17. ncbi 5-Hydroxytryptamine selectively activates the vagal nodose C-fibre subtype in the guinea-pig oesophagus
    S Yu
    Pennsylvania State University, College of Medicine, Hershey, PA, USA
    Neurogastroenterol Motil 20:1042-50. 2008
    ..The response to 5-HT in nodose C-fibres is mediated by the 5-HT(3) receptor in their neuronal membrane...
  18. ncbi Immunohistochemical characteristics of neurons in nodose ganglia projecting to the different chambers of the rat heart
    Vana Kosta
    Department of Anatomy, Histology and Embryology, School of Medicine in Split, Soltanska 2, 21000 Split, Croatia
    Auton Neurosci 155:33-8. 2010
    ..11%). These findings reveal that chambers of the rat heart are innervated with immunohistochemically different subpopulations of neurons from the nodose ganglia...
  19. ncbi Detection of thromboxane A(2) receptor mRNA in rabbit nodose ganglion neurons
    Michael J Wacker
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
    Neurosci Lett 386:121-6. 2005
    ..Therefore, we conclude that the presence of TP mRNA in a subset of cultured nodose ganglion neurons allows for the possibility that TXA(2) may directly stimulate or modulate vagal afferent neurons.
  20. ncbi The effects of ouabain on resting membrane potential and hyperpolarization-activated current in neonatal rat nodose ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Life Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neurosci Lett 439:241-4. 2008
    ..the application of ouabain, one of the Na+-K+ pump inhibitors, in neonatal rat small-diameter (<30microm) nodose ganglion (NG) neurons, we examined the effects of 1microM ouabain on those responses using perforated patch-clamp ..
  21. ncbi Axotomy alters neurotrophin and neurotrophin receptor mRNAs in the vagus nerve and nodose ganglion of the rat
    P Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA
    Brain Res Mol Brain Res 87:31-41. 2001
    ..changes in mRNA expression of neurotrophins and their receptors in the transected vagus nerve and nodose ganglion. Studies using in situ hybridization histochemistry showed that axotomy of the cervical vagus nerve resulted ..
  22. ncbi Functional GABAB receptors are present in guinea pig nodose ganglion cell bodies but not in peripheral mechanosensitive endings
    Vladimir P Zagorodnyuk
    Department of Human Physiology, Centre for Neuroscience, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia, Australia
    Auton Neurosci 102:20-9. 2002
    The effects of the GABAB-selective agonist baclofen were studied on guinea pig nodose ganglion neurones using grease gap and intracellular recording techniques, and on peripheral mechanosensitive endings in the guinea pig oesophagus and ..
  23. pmc Comparative pharmacology of cholecystokinin induced activation of cultured vagal afferent neurons from rats and mice
    Dallas C Kinch
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 7:e34755. 2012
    ..The pure antagonistic action of JMV-180 in this in vitro preparation suggests that prior reported differential effects of JMV-180 on satiation in rats versus mouse must be mediated by a site other than vagal afferent activation...
  24. ncbi Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel
    Yu Long Li
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 79:715-21. 2008
    ..The nodose ganglion (NG) contains the cell bodies of the aortic baroreceptor (AB) neurons...
  25. ncbi The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion
    Jacob Jelsing
    Rheoscience A S, Rødovre, Denmark Gubra, Copenhagen, Denmark
    Neurosci Lett 463:125-9. 2009
    ..paraventricular (PVN) and ventromedial hypothalamic (VMH) nucleus, in the brainstem dorsal vagal complex or nodose ganglion of lean Zucker rats, CB(1)R mRNA levels were consistently elevated in obese Zucker rats pointing to a direct ..
  26. ncbi TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus
    Shaoyong Yu
    Division of Gastroenterology and Hepatology, The Milton S Hershey Medical Center, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Gastrointest Liver Physiol 297:G34-42. 2009
    ..Collectively, our data provide new evidence that sensitizing TRPA1 via a PAR2-dependent mechanism plays an important role in mast cell activation-induced mechanical hypersensitivity of vagal nodose C-fibers in guinea pig esophagus...
  27. ncbi Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons
    Yusaku Iwasaki
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 320 0498, Japan
    Neuropeptides 47:19-23. 2013
    ..we examined the effects of PP and PYY(3-36) on cytosolic Ca(2+) concentration ([Ca(2+)](i)) in isolated nodose ganglion neurons of the mouse vagal afferent nerves...
  28. ncbi Release of calcitonin gene-related peptide from the jugular-nodose ganglion complex in rats--a new model to examine the role of cardiac peptidergic and nitrergic innervation
    Thomas Strecker
    Institute of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nurnberg, Universitätsstr 17, D 91054 Erlangen, Germany
    Neuropeptides 42:543-50. 2008
    ..lung is conveyed to the brainstem by primary afferent fibers originating from vagal sensory neurons (jugular-nodose ganglion complex, JNC)...
  29. ncbi The influence of exercise on morphological and neurochemical properties of neurons in rat nodose ganglia
    Vana Kosta
    Department of Anatomy, Histology and Embryology, University of Split, School of Medicine, Soltanska 2, 21000 Split, Croatia
    Neurosci Lett 490:36-40. 2011
    ..These data indicate that exercise leads to plastic changes in nodose ganglia neurons that may initiate changes of vagal activity caused by prolonged exercise...
  30. ncbi Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells
    H Tu
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Neuroscience 165:39-52. 2010
    ..the protein expression and the electrophysiological characteristics of HCN channels were investigated in nodose ganglion (NG) afferent neurons (A-fiber and C-fiber neurons) from sham and streptozotocin (STZ)-induced diabetic rats...
  31. ncbi Effects of artemisinin on action potentials from C-type nodose ganglion neurons
    Guo Fen Qiao
    Department of Pharmacology, Harbin Medical University, Harbin 150086, China
    Acta Pharmacol Sin 24:937-42. 2003
    ..To investigate the effects of artemisinin (Art) on the action potentials (AP) recorded from identified C-type nodose neurons and study its anti-arrhythmic and anesthetic mechanisms...
  32. ncbi Peripheral but not central axotomy promotes axonal outgrowth and induces alterations in neuropeptide synthesis in the nodose ganglion of the rat
    M Reimer
    Department of Animal Physiology, Lund University, Sweden
    Eur J Neurosci 11:3415-23. 1999
    We investigated the effects of central and peripheral axotomy of the sensory neurons in the nodose ganglion on neurite outgrowth and neuropeptide expression...
  33. pmc Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats
    Gabriel Paulino
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, 1321 Haring Hall, Vet Med APC, University of California, Davis, 1 Shields Ave, Davis, CA 95616, USA
    Am J Physiol Endocrinol Metab 296:E898-903. 2009
    ..Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets...
  34. ncbi Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion
    Ichiro Sakata
    Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo ohkubo, 338 8570, Saitama, Japan
    Neurosci Lett 342:183-6. 2003
    ..In this study, we studied the expression of GHS-R mRNA in the rat nodose ganglion by reverse transcriptase-polymerase chain reaction and in situ hybridization, the results of which clearly ..
  35. ncbi Expression of the leptin receptor in rat and human nodose ganglion neurones
    G Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Neuroscience 109:339-47. 2002
    ..Moreover, RT-PCR revealed the long form of the leptin receptor in a human nodose ganglion. The identities of RT-PCR products were confirmed by sequencing...
  36. ncbi Persistent tetrodotoxin-resistant Na+ currents are activated by prostaglandin E2 via cyclic AMP-dependent pathway in C-type nodose neurons of adult rats
    Baiyan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 355:1064-8. 2007
    ....
  37. ncbi Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus
    Christian Peiser
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite, Virchow Campus, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 320:41-4. 2002
    ..leptin signals from the stomach to the brain, leptin receptor (OB-R) expression was investigated in rat nodose ganglion cells and their projection to the stomach determined by retrograde tracing...
  38. pmc Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats
    Huiyin Tu
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    J Neurophysiol 107:591-602. 2012
    ....
  39. pmc Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Br J Pharmacol 145:503-13. 2005
    ..on the modification of the tetrodotoxin-resistant Na+ current (I(NaR)) in acutely isolated neonatal rat nodose ganglion (NG) neurones. 2 Of the four EP receptor agonists ranging from 0...
  40. pmc Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors
    Hao Sun
    Department of Anesthesiology and Perioperative Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Pharmacol Exp Ther 331:851-9. 2009
    ..was present on nerve fibers and terminals in the adventitia of the ascending aorta and aortic arch, the nodose ganglion neurons, and afferent fibers in the solitary tract of the brainstem...
  41. ncbi The effect of PKC activity on the TTX-R sodium currents from rat nodose ganglion neurons
    Mizuho Ikeda
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 78:47-53. 2005
    ..activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, ..
  42. ncbi Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey
    S Lamontagne
    Department of Biochemistry and Molecular Biology, Dorval-Pointe-Claire, H9R 4P8, , Canada
    Brain Res 920:84-96. 2001
    ..The distribution of three PDE4 isoforms (A, C and D) has been investigated in the squirrel monkey medulla and nodose ganglion to determine which isoform(s) could be responsible for the emetic adverse effects...
  43. ncbi P2X2/3 receptor activity of rat nodose ganglion neurons contributing to myocardial ischemic nociceptive signaling
    Fang Wan
    Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, PR China
    Auton Neurosci 158:58-64. 2010
    ..The present results have shown that the sensitivity of P2X(2/3) receptor in nodose ganglion neurons was increased after myocardial ischemic injury under electrophysiological observation...
  44. ncbi Upregulation of NMDA receptor and neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats
    Hung Ming Chang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    J Chem Neuroanat 25:137-47. 2003
    ..the present study aimed to examine if the expression of nNOS and NMDA receptor subunit 1 (NMDAR1) in the nodose ganglion (NG) would alter under different extents of hypoxia treatment...
  45. ncbi Effect of 8-bromo-cAMP on the tetrodotoxin-resistant sodium (Nav 1.8) current in small-diameter nodose ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neuropharmacology 52:904-24. 2007
    ..8-Br-cAMP)-induced modification of tetrodotoxin-resistant (TTX-R) sodium current in neonatal rat nodose ganglion neurons is mediated by the activation of protein kinase A (PKA) and/or protein kinase C (PKC)...
  46. ncbi Plasticity of nodose ganglion neurons after capsaicin- and vagotomy-induced nerve damage in adult rats
    V Ryu
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163 6520, USA
    Neuroscience 167:1227-38. 2010
    Previous reports show that vagal afferent innervation of the stomach eventually regenerates from surviving nodose ganglion (NG) neurons after subdiaphragmatic vagotomy...
  47. ncbi Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurones of adult rats
    Guofen Qiao
    Department of Pharmacology, Harbin Medical University, Biopharmaceutical Engineering Key Laboratory of Heilongjiang Province, Incubator of State Key Laboratory, Harbin, China
    Basic Clin Pharmacol Toxicol 100:217-24. 2007
    ..of artemisinin on action potential discharge and voltage-gated ion channels properties were studied on nodose ganglion neurones of adult rats with known sensory afferent fibre type using whole cell patch and vagus nodose slice ..
  48. ncbi Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons
    Masafumi Kakei
    Department of Geriatric Medicine, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Auton Neurosci 102:39-44. 2002
    ..To examine whether GLP-1 directly activates single neurons isolated from the rat nodose ganglion, GLP-1-induced changes of the membrane potential and cytosolic-free Ca2+ concentration ([Ca2+]i) in the cells ..
  49. ncbi Melatonin attenuates the neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats
    Hung Ming Chang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei
    J Pineal Res 32:65-73. 2002
    ..nitric oxide synthase (nNOS) immunohistochemistry were used to detect the NADPH-d/nNOS reactivity in the nodose ganglion (NG) at various time points following the hypoxic exposure...
  50. ncbi GM1 ganglioside contributes to retain the neuronal conduction and neuronal excitability in visceral and baroreceptor afferents
    Guo Fen Qiao
    Department of Pharmacology, Harbin Medical University, Harbin, China
    J Neurochem 106:1637-45. 2008
    ..At soma of myelinated A and unmyelinated C-type nodose ganglion neurons (NGNs), the action potential spike frequency reduced by CTX-B is also prevented by GM1...
  51. ncbi Distribution and colocalization of NGF and GDNF family ligand receptor mRNAs in dorsal root and nodose ganglion neurons of adult rats
    Hitoshi Kashiba
    Department of Physiology, Kansai College of Oriental Medicine, 2 11 1 Wakaba, Kumatori, Sennan, Osaka 590 0433, Japan
    Brain Res Mol Brain Res 110:52-62. 2003
    ..NGF) and glial cell line-derived neurotrophic factor (GDNF) family ligands in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons of adult rats by in situ hybridization (ISH) histochemistry using serial sections...
  52. ncbi Altered production of nitric oxide and reactive oxygen species in rat nodose ganglion neurons during acute hypoxia
    Yoshio Yamamoto
    Institute of Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Brain Res 961:1-9. 2003
    Nitric oxide (NO) production in the sensory neurons of the rad nodose ganglion was studied by examining the distribuiotn of NO synthase (NOS) by use of NADPH diaphorase (NADPHD) histochemistry and immunohistochemistry ofr the presence of ..
  53. ncbi Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Brain Res 999:73-80. 2004
    ..This study aimed to explore the potential neuroprotective effect of EGCG on the ganglionic neurons of the nodose ganglion (NG) in acute hypoxic rats. Thus, the young adult rats were pretreated with EGCG (10, 25, or 50 mg/kg, i.p...
  54. ncbi Evidence for nodose ganglion as the source of innervation to the anterior lobe of the pituitary gland
    S Vanhatalo
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Finland
    Neuroscience 107:491-7. 2001
    ..or superior cervical ganglion were substance P-immunoreactive, while many of the neuronal cell bodies in the nodose ganglion exhibited substance P immunoreactivity...
  55. ncbi Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats
    B Banerjee
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurogastroenterol Motil 19:681-91. 2007
    ..The over expression of TRPV1 may contribute to oesophageal hypersensitivity observed in gastro-oesophageal reflux disease (GORD)...
  56. ncbi NMDA channels control meal size via central vagal afferent terminals
    B R Gillespie
    Department of Veterinary Comparative Anatomy Physiology Pharmacology, College of Veterinary Medicine, Washington State Univ, Rm 205 Wegner Hall, Pullman, Washington 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1504-11. 2005
    ..we examined 15% sucrose intake after 50-nl MK-801 injections ipsilateral or contralateral to unilateral nodose ganglion removal (ganglionectomy)...
  57. ncbi Leptin and CCK modulate complementary background conductances to depolarize cultured nodose neurons
    J H Peters
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164 6520, USA
    Am J Physiol Cell Physiol 290:C427-32. 2006
    ....
  58. ncbi Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons
    K Dang
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 286:G573-9. 2004
    ..83.6 +/- 2.2 mV) associated with an acceleration of inactivation kinetics. These data suggest that a reduction in K(+) currents contributes, in part, to increased neuron excitability that may lead to development of dyspeptic symptoms...
  59. ncbi Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependent
    H Yang
    CURE, Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 128:131-41. 2004
    ..Secretin injected i.p. may signal to the brain by interacting with secretin receptors on vagal afferent as well as on AP neurons outside the blood-brain barrier...
  60. ncbi Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung
    Malte Plato
    Institute for Anatomy and Cell Biology, University of Giessen Lung Center, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Neurosci Lett 395:215-9. 2006
    ..to the brainstem and to the spinal cord by primary afferent fibres originating from vagal sensory (jugular-nodose ganglion complex=JNC) and dorsal root ganglion (DRG) neurons, respectively...
  61. ncbi Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs
    L Atkinson
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Neuroscience 118:115-22. 2003
    ..of nNOS to vagal afferent fibres the anterograde tracer biotinylated dextran amine was injected into the nodose ganglion and detected in brainstem sections using peroxidase-based methods...
  62. pmc Characterization of acid signaling in rat vagal pulmonary sensory neurons
    Qihai Gu
    Dept of Physiology, Univ of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 291:L58-65. 2006
    ..The relative roles of these two current species depend on the range of pH and vary between neurons...
  63. ncbi Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats
    Jun Sakurai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, Hyogo, Japan
    Gastroenterology 134:1094-103. 2008
    ..kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade, in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons by noxious gastric distention (GD) and its involvement in acute visceral pain in rats.
  64. pmc N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat
    Krzysztof Czaja
    Programs in Neuroscience and Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, 99163 6520, USA
    J Comp Neurol 496:877-85. 2006
    ..1% of nodose neurons. Our results indicate that most vagal afferent neurons express NMDA receptor ion channels composed of NR1, NR2B, and NR2C subunits and that a minority phenotype that expresses NR2D also expresses NR1, NR2B, and NR2C...
  65. ncbi Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Cell Tissue Res 311:277-87. 2003
    ....
  66. ncbi Effect of extracellular calcium on excitability of guinea pig airway vagal afferent nerves
    Bradley J Undem
    Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD 21224, USA
    J Neurophysiol 89:1196-204. 2003
    ....
  67. ncbi Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons
    Jennings Xu
    Department of Physiology, University of Kentucky Medical Center, Lexington, KY 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 292:L54-61. 2007
    ..6% of the RARs tested. In conclusion, nicotine exerts a direct stimulatory effect on vagal pulmonary sensory nerves, and the effect is probably mediated through an activation of the NnAChRs expressed on the membrane of these neurons...
  68. ncbi Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes
    Krzysztof Czaja
    Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163 6520, USA
    Brain Res 1119:86-93. 2006
    ..However, the neuronal distribution of NMDA receptor subunits is not correlated with innervation of either the stomach or duodenum...
  69. ncbi Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin
    Galina Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 24:2708-15. 2004
    ..Because CCK is a satiety factor that acts via the vagus nerve and CB1 agonists stimulate food intake, the data suggest a new mechanism modulating the effect on food intake of satiety signals from the gastrointestinal tract...
  70. ncbi Reduced CCK-induced Fos expression in the hindbrain, nodose ganglia, and enteric neurons of rats lacking CCK-1 receptors
    Mihai Covasa
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA, 16802, USA
    Brain Res 1051:155-63. 2005
    ....
  71. ncbi Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosa
    Rudolf Schicho
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
    Eur J Neurosci 19:1811-8. 2004
    ..The TRPV1 receptor may be a key molecule in the transduction of acid-induced nociception of the gastric mucosa and a mediator of visceral hypersensitivity...
  72. pmc The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats
    Cynthia L Wladyka
    Rammelkamp Center for Research and Education R326, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    J Physiol 586:795-802. 2008
    ..We propose that KCNQ2, KCNQ3 and KCNQ5 channels provide a hyperpolarizing influence to offset the previously described depolarizing influence of the HCN channels in baroreceptor neurons and their terminals...
  73. ncbi Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels
    Xiaomeng Ren
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Mol Cell Neurosci 29:320-32. 2005
    ..Thus, interaction between transmembranes of DPP10/DPPX and Kv4 channel mediates functional complex formation. We call this protein DPPY, instead of DPP10, because of its revealed role as a Kv4 channel regulator...
  74. ncbi Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum
    J H Peters
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1544-9. 2006
    ..test this hypothesis, we measured changes in cytosolic calcium levels induced by leptin and CCK in cultured nodose ganglion neurons labeled with a retrograde neuronal tracer injected into either the stomach or the duodenum...
  75. ncbi Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons
    Amanda J Page
    Nerve Gut Research Laboratory, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Gastroenterology 128:402-10. 2005
    ..Metabotropic glutamate receptors (mGluR) belong to this receptor family and have great pharmacologic and molecular diversity, with 8 subtypes. We investigated mGluR in the vagal system of humans and other species...
  76. ncbi Secretin activates vagal primary afferent neurons in the rat: evidence from electrophysiological and immunohistochemical studies
    Ying Li
    Gastroenterology Research Unit, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 289:G745-52. 2005
    ..A subpopulation of secretin-sensitive vagal afferent fibers is located in the intestinal mucosa, many of which are responsive to luminal 5-HT...
  77. ncbi Neurochemical phenotype of vagal afferent neurons activated to express C-FOS in response to luminal stimulation in the rat
    X Y Wu
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan Health System, University of Michigan, 6510 Medical Sciences Research Building I, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0682, USA
    Neuroscience 130:757-67. 2005
    ..In addition, 44%, 38%, and 8% of 5-HT-stimulated and 30%, 32%, and 5% of maltose-stimulated c-Fos-positive neurons exhibited, respectively, Glu, SP, and CGRP immunoreactivity. The few neurons that contained SS did not express c-Fos...
  78. ncbi Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve
    Philip M Lang
    Department of Anesthesiology, University of Munich, Germany
    Auton Neurosci 136:100-4. 2007
    ..The presence of receptors indicates that circulating factors may modify vagal afferent neurons also by effects on the axonal membrane...
  79. pmc Endomorphin-2 is released from newborn rat primary sensory neurons in a frequency- and calcium-dependent manner
    Heather L Scanlin
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, OR 97239, USA
    Eur J Neurosci 27:2629-42. 2008
    ..These results point to END-2 as a likely mediator of activity-dependent plasticity in sensory pathways...
  80. ncbi Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons
    Charlotta Lindwall
    Department of Cell and Organism Biology, Lund University, SE 223 62 Lund, Sweden
    Mol Cell Neurosci 27:267-79. 2004
    ..Taken together, our results suggest that JNK-mediated c-Jun activation is one of the first cell body reactions in response to nerve injury and that this activation and subsequent ATF3 induction are associated with axonal outgrowth...
  81. ncbi Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin
    Guillaume de Lartigue
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 27:2876-82. 2007
    ....
  82. ncbi Nerve injury alters profile of receptor-mediated Ca2+ channel modulation in vagal afferent neurons of rat nodose ganglia
    Xue Zhu Huang
    Department of Physiology, Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Ilsan dong 162, Wonju, Kangwon Do 220 701, South Korea
    Neurosci Lett 364:189-94. 2004
    ..Taken together, these results demonstrated for the first time that the profile of neurotransmitter-induced Ca2+ channel modulation is significantly altered in the NG neurons under pathophysiological state of nerve injury...
  83. ncbi Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius
    Young Ho Jin
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 24:4709-17. 2004
    ..Together, results are consistent with segregation of glutamatergic terminals into either P2X sensitive or VR1 sensitive that correspondingly identify myelinated and unmyelinated afferent pathways at the NTS...
  84. ncbi [Morphometric characteristics of rat viscero- and somatosensory neurocytes of the caudal ganglia in the vagus nerve]
    M M Fateev
    Department of Normal Physiology, Yaroslavl State Medical Academy
    Morfologiia 125:27-9. 2004
    ..The reason for these discrepancies seems to be associated with the differences of viscero- and somatosensory relations...
  85. ncbi Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurophysiol 89:1985-93. 2003
    ....
  86. ncbi Dual sensory innervation of pulmonary neuroepithelial bodies
    Inge Brouns
    Laboratory of Cell Biology and Histology, University of Antwerp RUCA, Antwerp, Belgium
    Am J Respir Cell Mol Biol 28:275-85. 2003
    ..immunoreactive (IR) afferent nerve terminals contacting NEBs appeared to have their origin in the nodose ganglion. Thick CB/P2X(3)-IR nerve fibers were seen to be myelinated and to lose their myelin sheaths just before ..
  87. ncbi Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve
    M Buyse
    , , Paris, France
    Eur J Neurosci 14:64-72. 2001
    ..reaction, mRNAs encoding long (Ob-Rb) and short (Ob-Ra) leptin receptor isoforms were detected in the rat nodose ganglion, which contains the cell bodies of the vagal afferent neurons...
  88. pmc Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat
    J X Zhu
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    J Physiol 530:431-42. 2001
    ....
  89. ncbi Mechanosensory transduction of vagal and baroreceptor afferents revealed by study of isolated nodose neurons in culture
    Vladislav Snitsarev
    Auton Neurosci 98:59-63. 2002
    ..The results support the hypothesis that DEG/ENaC subunits are components of mechanosensitive ion channels on vagal afferent and baroreceptor neurons...
  90. pmc Sodium currents in vagotomized primary afferent neurones of the rat
    E Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201-1559, USA
    J Physiol 536:445-58. 2001
    1. Nodose ganglion neurones (NGNs) become less excitable following section of the vagus nerve...
  91. ncbi Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia
    H Ichikawa
    Department of Oral Function and Anatomy, Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 924:109-12. 2002
    ..The present findings may suggest that VRL-1 is associated with chemosensory functions in visceral sensory neurons...
  92. ncbi Vagal afferents innervating the gastrointestinal tract and CCKA-receptor immunoreactivity
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Anat Rec 266:10-20. 2002
    ....
  93. pmc Calcium and calcium-activated currents in vagotomized rat primary vagal afferent neurons
    Eric Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
    J Physiol 540:543-56. 2002
    Adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) were acutely isolated 4-6 days after section of their peripheral axons (vagotomy) and examined with the whole-cell patch-clamp technique...
  94. ncbi TRPC6 immunoreactivity is colocalized with neuronal nitric oxide synthase in extrinsic fibers innervating guinea pig intrinsic cardiac ganglia
    Michelle A Calupca
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Comp Neurol 450:283-91. 2002
    ..We found, in support of this conclusion, that TRPC6-IR cells were also present in sections of nodose ganglia...
  95. ncbi The origin of sensory innervation of the peritoneum in the rat
    Koichi Tanaka
    Department of Anatomy, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    Anat Embryol (Berl) 205:307-13. 2002
    ..When fluoro-gold was applied to the peripheral part of the diaphragm, nodose ganglion was negative, and dorsal root ganglia from T6 to T12 were positive...
  96. ncbi Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons
    K Bielefeldt
    Department of Internal Medicine, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Gastroenterology 122:394-405. 2002
    ..Voltage-dependent Na+ currents are important determinants of excitability. We hypothesized that gastric inflammation alters Na+ current properties in primary sensory neurons...
  97. ncbi Slow inactivation of sodium currents in the rat nodose neurons
    R Fazan
    School of Medicine of Triangulo Mineiro, Department of Biological Science, Uberaba, MG, Brazil
    Auton Neurosci 87:209-16. 2001
    ..The resulting prolonged decrease in membrane excitability may contribute to the different patterns of action potential generation observed in primary afferent neurons...
  98. ncbi CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intake
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 957:298-310. 2002
    ..The functional role of CART in vagal afferents and the site of food intake suppression by 4th ventricular CARTp remain to be determined...
  99. ncbi Vagotomy decreases excitability in primary vagal afferent somata
    E Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, Maryland 21201-1559, USA
    J Neurophysiol 85:247-53. 2001
    ..techniques were used to monitor membrane excitability changes in adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) 5 days following section of the vagus nerve (vagotomy)...
  100. ncbi Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans
    Galina Burdyga
    Department of Physiology and School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, England, UK
    Gastroenterology 124:129-39. 2003
    ..The purpose of the study was to determine whether vagal afferent neurons express OX-R1 and OX-R2 and whether orexin-A inhibits responses to CCK...
  101. ncbi Vagal intraganglionic laminar endings and intramuscular arrays mature at different rates in pre-weanling rat stomach
    Susan E Swithers
    Department of Psychological Sciences, 1364 Psychological Sciences, Purdue University, West Lafayette, IN 47907 1364, USA
    Auton Neurosci 102:13-9. 2002
    ....

Research Grants55

  1. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..and 2) to identify, using in vitro and in vivo electrophysiological recordings, plasticity-related changes in nodose ganglion neuronal response properties of traced urinary bladder and colon sensory afferents under conditions of tissue ..
  2. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark S Shapiro; Fiscal Year: 2010
    ..The elucidation of the mechanisms and functional role of AKAP79/150 in M-channel activity will shed light on how the nervous system functions in health and disease. ..
  3. Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
    Philipp E Scherer; Fiscal Year: 2013
    ..Combined, we feel we are uniquely positioned to address these questions that tie at the core of homeostatic control of energy homeostasis. ..
  4. Mechanism and functional role of AKAP79/150 in M current control
    Mark S Shapiro; Fiscal Year: 2012
    ....
  5. Targeting the DNA damage response pathway for the treatment of HSV esophagitis
    Oleg Alekseev; Fiscal Year: 2013
    ..Herpes esophagitis usually presents as a reactivation from latency in the nodose ganglion of the vagus nerve...
  6. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..Our second hypothesis is that the unique functional morphology of the occipital artery-nodose ganglion complex allows sustained increases in blood-borne factors to alter the synthesis of receptors in vagal ..
  7. CNS Pathways Regulating Ghrelin Effects on Body Weight
    Joel K Elmquist; Fiscal Year: 2012
    ..It is hoped that these studies will result in new targeted therapies to treat mood obesity, diabetes and eating disorders such as anorexia nervosa and bulimia nervosa. ..
  8. High Fat Feeding Promotes Malfunction of the Nodose Ganglia
    Chung Owyang; Fiscal Year: 2013
    ..Understanding the abnormalities in the signal transduction cascade in the NG following HFD may provide important therapeutic targets for the prevention or correction of hyperphagia in patients consuming HF diets. ..
  9. Respiratory Virus Induced Sensory Neuroplasticity
    Bradley J Undem; Fiscal Year: 2013
    ..silence gene expression in vagal sensory neurons in vivo with adeno-associated virus-sh-RNAs delivered to the nodose ganglion. The results from our multidisciplinary approach should be of intrinsic value in providing new knowledge ..
  10. Airway Sensory Neuroexcitability
    Bradley J Undem; Fiscal Year: 2013
    ..One type of C-fiber is derived from neurons associated with the vagal nodose ganglion;the other C-fiber phenotype is associated more with the jugular vagal ganglia (and spinal dorsal root ganglia)..
  11. Dysfunction of Baroreceptor Neurons in Heart Failure: Cellular and Molecular Mech
    Yu Long Li; Fiscal Year: 2013
    ....
  12. Functioning of Nodose Ganglia in Diabetes
    Chung Owyang; Fiscal Year: 2013
    ..Understanding the cellular and molecular mechanism responsible for abnormal functioning of the NG in the diabetic state will provide important therapeutic targets for the management of abnormal GI function in chronic diabetes. ..
  13. Characterization of Portal Vein Glucose Sensor Responsible for Satiety Control
    Chung Owyang; Fiscal Year: 2013
    ..Expression of Epac, Rap 2B, PLCe and TRESK in the nodose ganglia will be silenced by local application of specific siRNA of the molecule of interest into the nodose ganglia using electroporation. ..
  14. Role of Neurogenic Inflammation in Pancreatic Cancer
    Brian M Davis; Fiscal Year: 2013
    ..Aim 1: Determine the effect of PDAC-produced neurotrophic factors on pancreatic afferents (dorsal root and nodose ganglion neurons) and whether blocking these growth factors attenuates the release of neurogenic inflammatory ..
  15. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  16. Neurotrophins and Development of Baroreceptor Pathways.
    Agnieszka Balkowiec; Fiscal Year: 2009
    ..This hypothesis, supported by our recently published data and preliminary studies, will be tested using nodose ganglion primary and second-order sensory neurons, as well as functionally homogenous primary and second-order neurons ..
  17. CHEMORECEPTOR ACTIVITY OF THE CAROTID BODY
    Carlos Eyzaguirre; Fiscal Year: 1990
    ..synapses between sensory neurons and glomus cells and made by transplanting or apposing CB fragments to the nodose ganglion to take advantage of electrotonic spread from nerve terminals...
  18. ESOPHAGEAL RECEPTOR REFLEXES: BRAINSTEM CIRCUITRY
    STEVEN ALTSCHULER; Fiscal Year: 1991
    ..the antidromic mapping technique will be used to determine the sites of projection and branching pattern of nodose ganglion neurons, having esophageal receptor endings that respond to stimuli which evoke crural inhibition...
  19. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth Kellar; Fiscal Year: 2007
    ..abstract_text> ..
  20. Autoimmune Mechanisms of Diabetic Neuropathy
    John W Wiley; Fiscal Year: 2010
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. . ..
  21. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2005
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  22. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2004
    ..This should provide a comprehensive characterization of the neural components of the vagovagal circuit activated by secretin to effect gastric relaxation. ..
  23. NEUROHORMONAL MECHANISMS IN HYPERTENSION
    Karen Barnes; Fiscal Year: 1992
    ..2) the ability of Angs to alter the release of substance P, norepinephrine, and serotonin from DMM slices and nodose ganglion explants; 3) the transport mechanisms and functional significance of Ang binding sites in the DMM and ..
  24. Cardiac Neuropathy in Type 1 Diabetic and Aging
    Zixi Cheng; Fiscal Year: 2007
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the two motor nuclei, i.e., the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX)...
  25. Aging, Episodic Hypoxia, and Vagal Cardiac Projections.
    Zixi Cheng; Fiscal Year: 2007
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the motor neuron pools in the brainstem, i.e...
  26. CARDIOPULMONARY REFLEXES AND THEIR ANATOMICAL BASIS
    DAVID KOSTREVA; Fiscal Year: 1980
    ..The distribution of these afferents arising from the nodose ganglion or dorsal root ganglion of each spinal segment is not clearly known...
  27. ION CHANNELS IN MECHANOSENSITIVE NEURONS
    DIANA KUNZE; Fiscal Year: 2007
    ..sensory receptors of myelinated and unmyelinated fibers in the arch of the aorta, in their soma in the nodose ganglion and in their synaptic terminals in the nucleus of the solitary tract...
  28. PURDUE INTEGRATIVE NEUROSCIENCE PROGRAM
    TERRY POWLEY; Fiscal Year: 2002
    ..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
  29. AUTONOMIC CONTROL OF BODY WEIGHT AND FEEDING
    TERRY POWLEY; Fiscal Year: 2006
    ..abstract_text> ..
  30. MAST CELL NERVE INTERACTIONS IN AIRWAYS
    Bradley J Undem; Fiscal Year: 2010
    ..The results may also shed new light on the complex pathophysiology of allergic airway diseases, i.e., asthma, and ultimately suggest new therapeutic strategies for treatment of these complex disorders. ..
  31. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
    ..Moreover, it will form an essential foundation for further research on the development of, and the structural and functional organization of, the diverse systems that form the vagal sensorium. ..
  32. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
  33. Molecular Pain Mechanisms
    Gerard P Ahern; Fiscal Year: 2010
    ..In Aim 3 we plan to identify nociceptive behaviors and pathology arising from cationic regulation of TRPV1. ..
  34. Calcium Signaling in Dendritic Cell Function
    Gerard Ahern; Fiscal Year: 2006
    ..Aim 2 tests the impact of endogenous and pharmacologic activators of RyR1 on DC. In Aim 3, we will elucidate the role of calcium-triggered secretion in DC. ..
  35. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2005
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  36. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..This information may, therefore, help to develop new therapeutic strategies for alleviating the symptoms of bronchial hyperreactivity associated with airway mucosal inflammation. ..
  37. REGULATION OF CALCIUM RELEASE IN INTESTINAL MYOCYTES
    Klaus Bielefeldt; Fiscal Year: 2002
    ..A better understanding of mechanisms that control the calcium homeostasis may provide important insight into the etiology of diseases or lead to the development of novel treatment strategies for functional abnormalities. ..
  38. Role of TRPV1 in Airway Hypersensitivity Induced by Inflammation
    Lu Yuan Lee; Fiscal Year: 2010
    ..The results obtained from these studies should bring a new insight into the pathogenesis and therapeutic strategy for alleviating the airway hypersensitivity. ..
  39. Chemosensitivity of Tachykinin-containing Lung Afferents
    Lu Yuan Lee; Fiscal Year: 2008
    ..The results obtained from this study should provide critical information for gaining new insights into the mechanisms underlying the airway hyperresponsiveness induced by cationic proteins. [unreadable] [unreadable]..
  40. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006
    ..abstract_text> ..
  41. AUTONOMIC REGULATION OF AIRWAY SMOOTH MUSCLE TONE
    BRENDAN CANNING; Fiscal Year: 2001
    ..It is anticipated that this information will improve our understanding of the role of the autonomic innervation of the healthy and diseased lung. ..
  42. DIFFERENTIAL VULNERABILITY TO MORBIDITIES OF SLEEP APNEA
    Sigrid Veasey; Fiscal Year: 2003
    ..Therefore, this work provides an essential foundation for determining gene function in the susceptibility of sleepiness, impaired cognation and behavioral responses caused by obstructive sleep apnea. (End of Abstract.) ..
  43. KININS AS MEDIATORS OF HUMAN REACTIONS
    BRENDAN CANNING; Fiscal Year: 2003
    ..These rigorous studies will not only clarify the role of BK in airway diseases, but will also have broader relevance by providing new and important insights into how neural function is altered in asthma and rhinitis. ..
  44. Neuroplasticity and the carotid body
    Estelle Gauda; Fiscal Year: 2009
    ..abstract_text> ..
  45. ONTOGENY OF METABOLIC CONTROLS OF INGESTIVE BEHAVIOR
    SUSAN SWITHERS; Fiscal Year: 2002
    ..Finally, the neural mechanisms involved in translating physiological changes related to energy utilization into increases in ingestive behavior are tested. ..
  46. Mechanisms of activation of vagal afferent neurons
    Steven Simasko; Fiscal Year: 2009
    ..A better appreciation of this important signaling pathway will contribute to the understanding of energy homeostasis and GI function, and aid in the design of therapeutic interventions for better health. ..
  47. Nicotine induced neuroplasticity in the carotid body
    Estelle Gauda; Fiscal Year: 2004
    ....
  48. Mast Cell Role in Masseter Muscle Repair
    JOYCE MORRIS WIMAN; Fiscal Year: 2005
    ....
  49. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
    ..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..
  50. Mechanisms of Alcohol Effects on Sleep
    Steven Simasko; Fiscal Year: 2006
    ..Such interventions could prove to be a useful adjunct to treat recovering alcoholics since prolonged sleep disturbances are a predicting factor for relapse into drinking behavior. ..
  51. Sleep Apnea: Upper Airway Nerve Injury
    Sigrid Veasey; Fiscal Year: 2009
    ..Collectively, the proposed studies will unveil important mechanisms of neuronal injury in obstructive sleep apnea and should reveal diabetes is a risk factor for this neural injury in sleep apnea. ..
  52. Clonidine Treatment for Neonatal Abstinence Syndrome
    Estelle Gauda; Fiscal Year: 2006
    ..abstract_text> ..
  53. Reflexes and Supraesophageal Consequences of Reflux Disease
    Brendan J Canning; Fiscal Year: 2010
    ..This research may also help identify novel therapeutic strategies for treating both GERD and chronic cough. ..
  54. DUAL ENZYME-BASED MICROBIOSENSOR TO MEASURE ATP RELEASE FROM THE CAROTID BODY
    Estelle Gauda; Fiscal Year: 2008
    ..This grant proposes to develop a microbiosensor to measure the release of ATP from the carotid body to understand how the newborn develops an adequate breathing response to changes in oxygen concentration. [unreadable] [unreadable]..