nodose ganglion

Summary

Summary: The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.

Top Publications

  1. ncbi Neuronal NADPH-d/NOS expression in the nodose ganglion of severe hypoxic rats with or without mild hypoxic preconditioning
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Chem Neuroanat 29:149-56. 2005
  2. ncbi Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion
    Ichiro Sakata
    Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo ohkubo, 338 8570, Saitama, Japan
    Neurosci Lett 342:183-6. 2003
  3. pmc Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs
    Kevin Kwong
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Physiol 586:1321-36. 2008
  4. ncbi Axotomy alters neurotrophin and neurotrophin receptor mRNAs in the vagus nerve and nodose ganglion of the rat
    P Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA
    Brain Res Mol Brain Res 87:31-41. 2001
  5. pmc Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia
    Bai Yan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Neurosci Methods 164:75-85. 2007
  6. ncbi Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus
    Christian Peiser
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite, Virchow Campus, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 320:41-4. 2002
  7. ncbi Expression of the leptin receptor in rat and human nodose ganglion neurones
    G Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Neuroscience 109:339-47. 2002
  8. doi Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells
    H Tu
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Neuroscience 165:39-52. 2010
  9. ncbi Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion
    Toru Hosoi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Auton Neurosci 120:104-7. 2005
  10. ncbi Effects of artemisinin on action potentials from C-type nodose ganglion neurons
    Guo Fen Qiao
    Department of Pharmacology, Harbin Medical University, Harbin 150086, China
    Acta Pharmacol Sin 24:937-42. 2003

Research Grants

Detail Information

Publications217 found, 100 shown here

  1. ncbi Neuronal NADPH-d/NOS expression in the nodose ganglion of severe hypoxic rats with or without mild hypoxic preconditioning
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Chem Neuroanat 29:149-56. 2005
    ..hypoxic preconditioning (MHPC)-induced NOS expression would attenuate the neuropathological changes in the nodose ganglion (NG) of severe hypoxic exposure (SHE) rats...
  2. ncbi Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion
    Ichiro Sakata
    Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo ohkubo, 338 8570, Saitama, Japan
    Neurosci Lett 342:183-6. 2003
    ..In this study, we studied the expression of GHS-R mRNA in the rat nodose ganglion by reverse transcriptase-polymerase chain reaction and in situ hybridization, the results of which clearly ..
  3. pmc Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs
    Kevin Kwong
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Physiol 586:1321-36. 2008
    ..we obtained data supporting the hypothesis that the TTX-R sodium currents are similarly distributed between nodose ganglion A-fibres and C-fibres innervating the lung...
  4. ncbi Axotomy alters neurotrophin and neurotrophin receptor mRNAs in the vagus nerve and nodose ganglion of the rat
    P Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814, Bethesda, MD, USA
    Brain Res Mol Brain Res 87:31-41. 2001
    ..changes in mRNA expression of neurotrophins and their receptors in the transected vagus nerve and nodose ganglion. Studies using in situ hybridization histochemistry showed that axotomy of the cervical vagus nerve resulted ..
  5. pmc Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia
    Bai Yan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Neurosci Methods 164:75-85. 2007
    ..An intact rat nodose ganglion preparation was used to randomly sample neurons (n=76) using the patch clamp technique...
  6. ncbi Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus
    Christian Peiser
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite, Virchow Campus, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 320:41-4. 2002
    ..leptin signals from the stomach to the brain, leptin receptor (OB-R) expression was investigated in rat nodose ganglion cells and their projection to the stomach determined by retrograde tracing...
  7. ncbi Expression of the leptin receptor in rat and human nodose ganglion neurones
    G Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Neuroscience 109:339-47. 2002
    ..Moreover, RT-PCR revealed the long form of the leptin receptor in a human nodose ganglion. The identities of RT-PCR products were confirmed by sequencing...
  8. doi Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells
    H Tu
    Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Neuroscience 165:39-52. 2010
    ..the protein expression and the electrophysiological characteristics of HCN channels were investigated in nodose ganglion (NG) afferent neurons (A-fiber and C-fiber neurons) from sham and streptozotocin (STZ)-induced diabetic rats...
  9. ncbi Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion
    Toru Hosoi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Auton Neurosci 120:104-7. 2005
    ..In the present study, we found that TLR4 mRNA and protein was expressed in the rat nodose ganglion. Thus, it is suggested that LPS could activate afferent vagus nerve at the level of nodose ganglion, which ..
  10. ncbi Effects of artemisinin on action potentials from C-type nodose ganglion neurons
    Guo Fen Qiao
    Department of Pharmacology, Harbin Medical University, Harbin 150086, China
    Acta Pharmacol Sin 24:937-42. 2003
    ..To investigate the effects of artemisinin (Art) on the action potentials (AP) recorded from identified C-type nodose neurons and study its anti-arrhythmic and anesthetic mechanisms...
  11. pmc Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats
    Gabriel Paulino
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, 1321 Haring Hall, Vet Med APC, University of California, Davis, 1 Shields Ave, Davis, CA 95616, USA
    Am J Physiol Endocrinol Metab 296:E898-903. 2009
    ..Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets...
  12. ncbi Peripheral but not central axotomy promotes axonal outgrowth and induces alterations in neuropeptide synthesis in the nodose ganglion of the rat
    M Reimer
    Department of Animal Physiology, Lund University, Sweden
    Eur J Neurosci 11:3415-23. 1999
    We investigated the effects of central and peripheral axotomy of the sensory neurons in the nodose ganglion on neurite outgrowth and neuropeptide expression...
  13. ncbi Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats
    I Hua Wei
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    Brain Res 999:73-80. 2004
    ..This study aimed to explore the potential neuroprotective effect of EGCG on the ganglionic neurons of the nodose ganglion (NG) in acute hypoxic rats. Thus, the young adult rats were pretreated with EGCG (10, 25, or 50 mg/kg, i.p...
  14. ncbi The effect of PKC activity on the TTX-R sodium currents from rat nodose ganglion neurons
    Mizuho Ikeda
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Life Sci 78:47-53. 2005
    ..activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, ..
  15. pmc Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat
    Guangfan Zhang
    Department of Physiology, University of Kentucky Medical Center, 800 Rose Street Lexington, KY 40536 0298, USA
    J Physiol 586:5771-86. 2008
    ..In conclusion, allergen-induced airway inflammation clearly elevated capsaicin sensitivity in myelinated pulmonary afferents, which probably resulted from an increased expression of TRPV1 in these sensory nerves...
  16. pmc Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Br J Pharmacol 145:503-13. 2005
    ..on the modification of the tetrodotoxin-resistant Na+ current (I(NaR)) in acutely isolated neonatal rat nodose ganglion (NG) neurones. 2 Of the four EP receptor agonists ranging from 0...
  17. pmc Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors
    Hao Sun
    Department of Anesthesiology and Perioperative Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Pharmacol Exp Ther 331:851-9. 2009
    ..was present on nerve fibers and terminals in the adventitia of the ascending aorta and aortic arch, the nodose ganglion neurons, and afferent fibers in the solitary tract of the brainstem...
  18. ncbi Effect of 8-bromo-cAMP on the tetrodotoxin-resistant sodium (Nav 1.8) current in small-diameter nodose ganglion neurons
    Shigeji Matsumoto
    Department of Physiology, Nippon Dental University, School of Dentistry at Tokyo, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Neuropharmacology 52:904-24. 2007
    ..8-Br-cAMP)-induced modification of tetrodotoxin-resistant (TTX-R) sodium current in neonatal rat nodose ganglion neurons is mediated by the activation of protein kinase A (PKA) and/or protein kinase C (PKC)...
  19. ncbi P2X2/3 receptor activity of rat nodose ganglion neurons contributing to myocardial ischemic nociceptive signaling
    Fang Wan
    Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, PR China
    Auton Neurosci 158:58-64. 2010
    ..The present results have shown that the sensitivity of P2X(2/3) receptor in nodose ganglion neurons was increased after myocardial ischemic injury under electrophysiological observation...
  20. ncbi Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons
    Masafumi Kakei
    Department of Geriatric Medicine, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Auton Neurosci 102:39-44. 2002
    ..To examine whether GLP-1 directly activates single neurons isolated from the rat nodose ganglion, GLP-1-induced changes of the membrane potential and cytosolic-free Ca2+ concentration ([Ca2+]i) in the cells ..
  21. ncbi Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey
    S Lamontagne
    Department of Biochemistry and Molecular Biology, Dorval-Pointe-Claire, H9R 4P8, , Canada
    Brain Res 920:84-96. 2001
    ..The distribution of three PDE4 isoforms (A, C and D) has been investigated in the squirrel monkey medulla and nodose ganglion to determine which isoform(s) could be responsible for the emetic adverse effects...
  22. ncbi Upregulation of NMDA receptor and neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats
    Hung Ming Chang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1, Section 1, Jen Ai Road, Taipei 100, Taiwan
    J Chem Neuroanat 25:137-47. 2003
    ..the present study aimed to examine if the expression of nNOS and NMDA receptor subunit 1 (NMDAR1) in the nodose ganglion (NG) would alter under different extents of hypoxia treatment...
  23. doi Plasticity of nodose ganglion neurons after capsaicin- and vagotomy-induced nerve damage in adult rats
    V Ryu
    Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163 6520, USA
    Neuroscience 167:1227-38. 2010
    Previous reports show that vagal afferent innervation of the stomach eventually regenerates from surviving nodose ganglion (NG) neurons after subdiaphragmatic vagotomy...
  24. ncbi Evidence for nodose ganglion as the source of innervation to the anterior lobe of the pituitary gland
    S Vanhatalo
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Finland
    Neuroscience 107:491-7. 2001
    ..or superior cervical ganglion were substance P-immunoreactive, while many of the neuronal cell bodies in the nodose ganglion exhibited substance P immunoreactivity...
  25. ncbi Altered production of nitric oxide and reactive oxygen species in rat nodose ganglion neurons during acute hypoxia
    Yoshio Yamamoto
    Institute of Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Brain Res 961:1-9. 2003
    Nitric oxide (NO) production in the sensory neurons of the rad nodose ganglion was studied by examining the distribuiotn of NO synthase (NOS) by use of NADPH diaphorase (NADPHD) histochemistry and immunohistochemistry ofr the presence of ..
  26. ncbi Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurones of adult rats
    Guofen Qiao
    Department of Pharmacology, Harbin Medical University, Biopharmaceutical Engineering Key Laboratory of Heilongjiang Province, Incubator of State Key Laboratory, Harbin, China
    Basic Clin Pharmacol Toxicol 100:217-24. 2007
    ..of artemisinin on action potential discharge and voltage-gated ion channels properties were studied on nodose ganglion neurones of adult rats with known sensory afferent fibre type using whole cell patch and vagus nodose slice ..
  27. ncbi Distribution and colocalization of NGF and GDNF family ligand receptor mRNAs in dorsal root and nodose ganglion neurons of adult rats
    Hitoshi Kashiba
    Department of Physiology, Kansai College of Oriental Medicine, 2 11 1 Wakaba, Kumatori, Sennan, Osaka 590 0433, Japan
    Brain Res Mol Brain Res 110:52-62. 2003
    ..NGF) and glial cell line-derived neurotrophic factor (GDNF) family ligands in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons of adult rats by in situ hybridization (ISH) histochemistry using serial sections...
  28. pmc Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons
    Patricia A Glazebrook
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44109, USA
    J Physiol 541:467-82. 2002
    ....
  29. ncbi Melatonin attenuates the neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats
    Hung Ming Chang
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei
    J Pineal Res 32:65-73. 2002
    ..nitric oxide synthase (nNOS) immunohistochemistry were used to detect the NADPH-d/nNOS reactivity in the nodose ganglion (NG) at various time points following the hypoxic exposure...
  30. ncbi Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells
    Atsushi Nakagawa
    Department of Internal Medicine, Kanazawa Medical University, Daigaku 1 1, Uchinada 920 0293, Japan
    Auton Neurosci 110:36-43. 2004
    ..derived from those electrophysiological observations, receptor gene expressions of GLP-1 and GIP in the rat nodose ganglion were examined by means of reverse transcriptase-mediated polymerase chain reaction (RT-PCR) and Northern blot ..
  31. ncbi Reduced CCK-induced Fos expression in the hindbrain, nodose ganglia, and enteric neurons of rats lacking CCK-1 receptors
    Mihai Covasa
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, 126 South Henderson, University Park, PA, 16802, USA
    Brain Res 1051:155-63. 2005
    ....
  32. ncbi CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intake
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 957:298-310. 2002
    ..The functional role of CART in vagal afferents and the site of food intake suppression by 4th ventricular CARTp remain to be determined...
  33. ncbi Secretin activates vagal primary afferent neurons in the rat: evidence from electrophysiological and immunohistochemical studies
    Ying Li
    Gastroenterology Research Unit, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 289:G745-52. 2005
    ..A subpopulation of secretin-sensitive vagal afferent fibers is located in the intestinal mucosa, many of which are responsive to luminal 5-HT...
  34. ncbi Mechanosensory transduction of vagal and baroreceptor afferents revealed by study of isolated nodose neurons in culture
    Vladislav Snitsarev
    Auton Neurosci 98:59-63. 2002
    ..The results support the hypothesis that DEG/ENaC subunits are components of mechanosensitive ion channels on vagal afferent and baroreceptor neurons...
  35. ncbi Long-term regeneration of abdominal vagus: efferents fail while afferents succeed
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, West Lafayette, Indiana 47907, USA
    J Comp Neurol 455:222-37. 2003
    ..Furthermore, the functional measures of disordered energy regulation did not normalize over the 45 weeks during which afferent but not efferent innervation was restored...
  36. ncbi Comparisons of somatic action potentials from dispersed and intact rat nodose ganglia using patch-clamp technique
    Bai Yan Li
    Experimental and Computational Neurobiology Laboratory, Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis 46202, USA
    Acta Pharmacol Sin 23:481-9. 2002
    ..To differentiate the electrophysiological characteristics of somatic action potentials (AP) from isolated Neo and Juv nodose sensory neurons (NSN) and those from slices of intact Juv and adult rat nodose ganglia...
  37. ncbi Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung
    Malte Plato
    Institute for Anatomy and Cell Biology, University of Giessen Lung Center, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Neurosci Lett 395:215-9. 2006
    ..to the brainstem and to the spinal cord by primary afferent fibres originating from vagal sensory (jugular-nodose ganglion complex=JNC) and dorsal root ganglion (DRG) neurons, respectively...
  38. ncbi Leptin and CCK modulate complementary background conductances to depolarize cultured nodose neurons
    J H Peters
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164 6520, USA
    Am J Physiol Cell Physiol 290:C427-32. 2006
    ....
  39. ncbi The origin of sensory innervation of the peritoneum in the rat
    Koichi Tanaka
    Department of Anatomy, Hyogo College of Medicine, 1 1 Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    Anat Embryol (Berl) 205:307-13. 2002
    ..When fluoro-gold was applied to the peripheral part of the diaphragm, nodose ganglion was negative, and dorsal root ganglia from T6 to T12 were positive...
  40. ncbi NMDA channels control meal size via central vagal afferent terminals
    B R Gillespie
    Department of Veterinary Comparative Anatomy Physiology Pharmacology, College of Veterinary Medicine, Washington State Univ, Rm 205 Wegner Hall, Pullman, Washington 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1504-11. 2005
    ..we examined 15% sucrose intake after 50-nl MK-801 injections ipsilateral or contralateral to unilateral nodose ganglion removal (ganglionectomy)...
  41. ncbi Vagal intraganglionic laminar endings and intramuscular arrays mature at different rates in pre-weanling rat stomach
    Susan E Swithers
    Department of Psychological Sciences, 1364 Psychological Sciences, Purdue University, West Lafayette, IN 47907 1364, USA
    Auton Neurosci 102:13-9. 2002
    ....
  42. ncbi Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels
    Xiaomeng Ren
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Mol Cell Neurosci 29:320-32. 2005
    ..Thus, interaction between transmembranes of DPP10/DPPX and Kv4 channel mediates functional complex formation. We call this protein DPPY, instead of DPP10, because of its revealed role as a Kv4 channel regulator...
  43. ncbi Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosa
    Rudolf Schicho
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
    Eur J Neurosci 19:1811-8. 2004
    ..The TRPV1 receptor may be a key molecule in the transduction of acid-induced nociception of the gastric mucosa and a mediator of visceral hypersensitivity...
  44. ncbi Nerve injury alters profile of receptor-mediated Ca2+ channel modulation in vagal afferent neurons of rat nodose ganglia
    Xue Zhu Huang
    Department of Physiology, Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Ilsan dong 162, Wonju, Kangwon Do 220 701, South Korea
    Neurosci Lett 364:189-94. 2004
    ..Taken together, these results demonstrated for the first time that the profile of neurotransmitter-induced Ca2+ channel modulation is significantly altered in the NG neurons under pathophysiological state of nerve injury...
  45. ncbi Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin
    Galina Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 24:2708-15. 2004
    ..Because CCK is a satiety factor that acts via the vagus nerve and CB1 agonists stimulate food intake, the data suggest a new mechanism modulating the effect on food intake of satiety signals from the gastrointestinal tract...
  46. ncbi Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependent
    H Yang
    CURE, Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 128:131-41. 2004
    ..Secretin injected i.p. may signal to the brain by interacting with secretin receptors on vagal afferent as well as on AP neurons outside the blood-brain barrier...
  47. ncbi Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons
    Charlotta Lindwall
    Department of Cell and Organism Biology, Lund University, SE 223 62 Lund, Sweden
    Mol Cell Neurosci 27:267-79. 2004
    ..Taken together, our results suggest that JNK-mediated c-Jun activation is one of the first cell body reactions in response to nerve injury and that this activation and subsequent ATF3 induction are associated with axonal outgrowth...
  48. ncbi Neurochemical phenotype of vagal afferent neurons activated to express C-FOS in response to luminal stimulation in the rat
    X Y Wu
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan Health System, University of Michigan, 6510 Medical Sciences Research Building I, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0682, USA
    Neuroscience 130:757-67. 2005
    ..In addition, 44%, 38%, and 8% of 5-HT-stimulated and 30%, 32%, and 5% of maltose-stimulated c-Fos-positive neurons exhibited, respectively, Glu, SP, and CGRP immunoreactivity. The few neurons that contained SS did not express c-Fos...
  49. ncbi Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons
    Amanda J Page
    Nerve Gut Research Laboratory, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Gastroenterology 128:402-10. 2005
    ..Metabotropic glutamate receptors (mGluR) belong to this receptor family and have great pharmacologic and molecular diversity, with 8 subtypes. We investigated mGluR in the vagal system of humans and other species...
  50. ncbi Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons
    K Dang
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 286:G573-9. 2004
    ..83.6 +/- 2.2 mV) associated with an acceleration of inactivation kinetics. These data suggest that a reduction in K(+) currents contributes, in part, to increased neuron excitability that may lead to development of dyspeptic symptoms...
  51. ncbi Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs
    L Atkinson
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Neuroscience 118:115-22. 2003
    ..of nNOS to vagal afferent fibres the anterograde tracer biotinylated dextran amine was injected into the nodose ganglion and detected in brainstem sections using peroxidase-based methods...
  52. ncbi Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Cell Tissue Res 311:277-87. 2003
    ....
  53. ncbi Effect of extracellular calcium on excitability of guinea pig airway vagal afferent nerves
    Bradley J Undem
    Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD 21224, USA
    J Neurophysiol 89:1196-204. 2003
    ....
  54. ncbi Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurophysiol 89:1985-93. 2003
    ....
  55. ncbi Dual sensory innervation of pulmonary neuroepithelial bodies
    Inge Brouns
    Laboratory of Cell Biology and Histology, University of Antwerp RUCA, Antwerp, Belgium
    Am J Respir Cell Mol Biol 28:275-85. 2003
    ..immunoreactive (IR) afferent nerve terminals contacting NEBs appeared to have their origin in the nodose ganglion. Thick CB/P2X(3)-IR nerve fibers were seen to be myelinated and to lose their myelin sheaths just before ..
  56. ncbi Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers
    Thanh N Doan
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Neurosci 24:3335-43. 2004
    ..At the sensory receptor terminal, CsCl decreased the threshold pressure for initiation of mechanoreceptor discharge. Therefore, elimination of the I(H) increases excitability of both the soma and the peripheral sensory terminals...
  57. ncbi Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans
    Galina Burdyga
    Department of Physiology and School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, England, UK
    Gastroenterology 124:129-39. 2003
    ..The purpose of the study was to determine whether vagal afferent neurons express OX-R1 and OX-R2 and whether orexin-A inhibits responses to CCK...
  58. ncbi [Morphometric characteristics of rat viscero- and somatosensory neurocytes of the caudal ganglia in the vagus nerve]
    M M Fateev
    Department of Normal Physiology, Yaroslavl State Medical Academy
    Morfologiia 125:27-9. 2004
    ..The reason for these discrepancies seems to be associated with the differences of viscero- and somatosensory relations...
  59. ncbi Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum
    J H Peters
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1544-9. 2006
    ..test this hypothesis, we measured changes in cytosolic calcium levels induced by leptin and CCK in cultured nodose ganglion neurons labeled with a retrograde neuronal tracer injected into either the stomach or the duodenum...
  60. ncbi Patch clamp electrophysiology in nodose ganglia of adult rat
    B Y Li
    Biomedical Engineering Program, Purdue School of Engineering and Technology, Indiana University, Room SL 174, 723 West Michigan Street, Indianapolis, IN 46202, USA
    J Neurosci Methods 115:157-67. 2002
    ..Here, we present a methodology for preparing nodose ganglion from adult rat (250-400 g) for study using the patch clamp technique...
  61. ncbi Slow inactivation of sodium currents in the rat nodose neurons
    R Fazan
    School of Medicine of Triangulo Mineiro, Department of Biological Science, Uberaba, MG, Brazil
    Auton Neurosci 87:209-16. 2001
    ..The resulting prolonged decrease in membrane excitability may contribute to the different patterns of action potential generation observed in primary afferent neurons...
  62. ncbi Vagal afferent neurons projecting to the stomach and small intestine exhibit multiple N-methyl-D-aspartate receptor subunit phenotypes
    Krzysztof Czaja
    Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, WA 99163 6520, USA
    Brain Res 1119:86-93. 2006
    ..However, the neuronal distribution of NMDA receptor subunits is not correlated with innervation of either the stomach or duodenum...
  63. ncbi Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius
    Young Ho Jin
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 24:4709-17. 2004
    ..Together, results are consistent with segregation of glutamatergic terminals into either P2X sensitive or VR1 sensitive that correspondingly identify myelinated and unmyelinated afferent pathways at the NTS...
  64. ncbi Local differences in vagal afferent innervation of the rat esophagus are reflected by neurochemical differences at the level of the sensory ganglia and by different brainstem projections
    M Wank
    Anatomisches Institut I, , 91054 Erlangen, Germany
    J Comp Neurol 435:41-59. 2001
    ..The present study provides a possible morphological basis for bronchopulmonary and aversive reflexes elicited upon stimulation of the esophagus...
  65. ncbi Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin
    Guillaume de Lartigue
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 27:2876-82. 2007
    ....
  66. pmc Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat
    J X Zhu
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    J Physiol 530:431-42. 2001
    ....
  67. ncbi Vagotomy decreases excitability in primary vagal afferent somata
    E Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, Maryland 21201-1559, USA
    J Neurophysiol 85:247-53. 2001
    ..techniques were used to monitor membrane excitability changes in adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) 5 days following section of the vagus nerve (vagotomy)...
  68. ncbi Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve
    Philip M Lang
    Department of Anesthesiology, University of Munich, Germany
    Auton Neurosci 136:100-4. 2007
    ..The presence of receptors indicates that circulating factors may modify vagal afferent neurons also by effects on the axonal membrane...
  69. ncbi Effect of reflux-induced inflammation on transient receptor potential vanilloid one (TRPV1) expression in primary sensory neurons innervating the oesophagus of rats
    B Banerjee
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurogastroenterol Motil 19:681-91. 2007
    ..The over expression of TRPV1 may contribute to oesophageal hypersensitivity observed in gastro-oesophageal reflux disease (GORD)...
  70. pmc The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats
    Cynthia L Wladyka
    Rammelkamp Center for Research and Education R326, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    J Physiol 586:795-802. 2008
    ..We propose that KCNQ2, KCNQ3 and KCNQ5 channels provide a hyperpolarizing influence to offset the previously described depolarizing influence of the HCN channels in baroreceptor neurons and their terminals...
  71. pmc Endomorphin-2 is released from newborn rat primary sensory neurons in a frequency- and calcium-dependent manner
    Heather L Scanlin
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, OR 97239, USA
    Eur J Neurosci 27:2629-42. 2008
    ..These results point to END-2 as a likely mediator of activity-dependent plasticity in sensory pathways...
  72. ncbi 5-Hydroxytryptamine selectively activates the vagal nodose C-fibre subtype in the guinea-pig oesophagus
    S Yu
    Pennsylvania State University, College of Medicine, Hershey, PA, USA
    Neurogastroenterol Motil 20:1042-50. 2008
    ..The response to 5-HT in nodose C-fibres is mediated by the 5-HT(3) receptor in their neuronal membrane...
  73. doi Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats
    Jun Sakurai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, Hyogo, Japan
    Gastroenterology 134:1094-103. 2008
    ..kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade, in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons by noxious gastric distention (GD) and its involvement in acute visceral pain in rats.
  74. ncbi Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve
    M Buyse
    , , Paris, France
    Eur J Neurosci 14:64-72. 2001
    ..reaction, mRNAs encoding long (Ob-Rb) and short (Ob-Ra) leptin receptor isoforms were detected in the rat nodose ganglion, which contains the cell bodies of the vagal afferent neurons...
  75. ncbi Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons
    Jennings Xu
    Department of Physiology, University of Kentucky Medical Center, Lexington, KY 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 292:L54-61. 2007
    ..6% of the RARs tested. In conclusion, nicotine exerts a direct stimulatory effect on vagal pulmonary sensory nerves, and the effect is probably mediated through an activation of the NnAChRs expressed on the membrane of these neurons...
  76. pmc Calcium and calcium-activated currents in vagotomized rat primary vagal afferent neurons
    Eric Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
    J Physiol 540:543-56. 2002
    Adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) were acutely isolated 4-6 days after section of their peripheral axons (vagotomy) and examined with the whole-cell patch-clamp technique...
  77. pmc Characterization of acid signaling in rat vagal pulmonary sensory neurons
    Qihai Gu
    Dept of Physiology, Univ of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 291:L58-65. 2006
    ..The relative roles of these two current species depend on the range of pH and vary between neurons...
  78. ncbi TRPC6 immunoreactivity is colocalized with neuronal nitric oxide synthase in extrinsic fibers innervating guinea pig intrinsic cardiac ganglia
    Michelle A Calupca
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Comp Neurol 450:283-91. 2002
    ..We found, in support of this conclusion, that TRPC6-IR cells were also present in sections of nodose ganglia...
  79. ncbi Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons
    K Bielefeldt
    Department of Internal Medicine, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Gastroenterology 122:394-405. 2002
    ..Voltage-dependent Na+ currents are important determinants of excitability. We hypothesized that gastric inflammation alters Na+ current properties in primary sensory neurons...
  80. ncbi Vagal afferents innervating the gastrointestinal tract and CCKA-receptor immunoreactivity
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Anat Rec 266:10-20. 2002
    ....
  81. ncbi Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia
    H Ichikawa
    Department of Oral Function and Anatomy, Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 924:109-12. 2002
    ..The present findings may suggest that VRL-1 is associated with chemosensory functions in visceral sensory neurons...
  82. pmc N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat
    Krzysztof Czaja
    Programs in Neuroscience and Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, 99163 6520, USA
    J Comp Neurol 496:877-85. 2006
    ..1% of nodose neurons. Our results indicate that most vagal afferent neurons express NMDA receptor ion channels composed of NR1, NR2B, and NR2C subunits and that a minority phenotype that expresses NR2D also expresses NR1, NR2B, and NR2C...
  83. pmc KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons
    Cynthia L Wladyka
    Rammelkamp Centre for Research and Education R326 MetroHealth Medical Centre, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    J Physiol 575:175-89. 2006
    ..These data indicate that the M-current is present in nodose neurons, is activated at resting membrane potential and that it is physiologically important in regulating excitability by maintaining cells at negative voltages...
  84. pmc Sodium currents in vagotomized primary afferent neurones of the rat
    E Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201-1559, USA
    J Physiol 536:445-58. 2001
    1. Nodose ganglion neurones (NGNs) become less excitable following section of the vagus nerve...
  85. ncbi The peripheral dopaminergic system: morphological analysis, functional and clinical applications
    F Amenta
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Italy
    Ital J Anat Embryol 107:145-67. 2002
    ..Dopamine recepetor protein immunostaining was also found in neurons of nodose ganglion, that display immunoreactivity for different neuropeptides...
  86. pmc Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis
    B J Canning
    Johns Hopkins Medical Institutions, Asthma and Allergy Center, Baltimore, MD 21224
    J Physiol 471:25-40. 1993
    ..4-3 m/s) conduction velocities.(ABSTRACT TRUNCATED AT 400 WORDS)..
  87. pmc Relaxant innervation of the guinea-pig trachealis: demonstration of capsaicin-sensitive and -insensitive vagal pathways
    B J Canning
    Johns Hopkins Medical Institutions, Asthma and Allergy Center, Baltimore, MD 21224
    J Physiol 460:719-39. 1993
    ....
  88. ncbi Serotonin2 receptors in the nucleus tractus solitarius: characterization and role in the baroreceptor reflex arc
    Laguzzi Raul
    INSERM U288, C H U Pitiè Salpêtrière, Paris 13, France
    Cell Mol Neurobiol 23:709-26. 2003
    ..They can be summarized as follows. 3. The selective destruction of the nodose ganglion-NTS serotonergic pathway produces a long-term increase in blood pressure variability, similar to that caused ..
  89. ncbi Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum
    Yasutada Akiba
    Department of Medicine, School of Medicine, University of California Los Angeles, USA
    Gastroenterology 131:142-52. 2006
    ..We examined the hyperemic response to elevated luminal PCO(2) in the duodenum of anesthetized rats luminally exposed to high CO(2) saline to help elucidate luminal acid-sensing mechanisms...
  90. ncbi Carotid body and glomus cells distributed in the wall of the common carotid artery in the bird
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Microsc Res Tech 59:196-206. 2002
    ..5, and HNK-1, which are continuous with the inferior vagal (nodose) ganglion, first surround and then invade both the carotid body rudiment and the other portions of the third branchial artery, becoming glomus cells...
  91. pmc Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs
    Christina Nassenstein
    Johns Hopkins Allergy and Asthma Center, Baltimore, MD 21224, USA
    J Physiol 588:4769-83. 2010
    ..Neurons of the nodose ganglion are derived from the epibranchial placodes, whereas jugular ganglion neurons are derived from the neural ..
  92. ncbi Calcium homeostasis in trigeminal ganglion cell bodies
    Tony D Gover
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, MD 21201 1559, United States
    Cell Calcium 41:389-96. 2007
    ..At pH 9.0, both the peak amplitude and decay time of the KCl-evoked Ca2+ transient were increased significantly. These data suggest that, in TGNs, the PMCA is the major mechanism for removing cytosolic Ca2+ following electrical activity...
  93. ncbi Calbindin D28k-immunoreactive afferent nerve endings in the laryngeal mucosa
    Y Yamamoto
    Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Japan
    Anat Rec 259:237-47. 2000
    ..The distribution of calbindin D28k-immunoreactivity may be differnt from that of calretinin. It is suggested that calbindin D28k have regulatory role on intracellular calcium concentration in the laryngeal sensory corpuscles...
  94. pmc Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia
    Siok L Dun
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Neurosci Res 87:1610-9. 2009
    ....
  95. pmc Inhibition of gastric motility by hyperglycemia is mediated by nodose ganglia KATP channels
    Shi Yi Zhou
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Physiol Gastrointest Liver Physiol 300:G394-400. 2011
    ..These studies provide in vivo evidence that hyperglycemia induces gastric relaxation via the vagal afferent pathway. This action is mediated through inactivation of nodose ganglia K(ATP) channels...
  96. ncbi Sensory signal transduction in the vagal primary afferent neurons
    Ying Li
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0682, USA
    Curr Med Chem 14:2554-63. 2007
    ..The nodose ganglion contains neurons that may possess only high- or low-affinity CCK-A receptors or 5-HT3 receptors...
  97. pmc Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets
    E R Partosoedarso
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Physiol 550:149-58. 2003
    ..receptor staining was present in cell bodies within the area postrema, nucleus tractus solitarius (NTS) and nodose ganglion. Intense terminal-like staining was noted within the NTS and dorsal motor vagal nucleus (DMN)...
  98. pmc Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat
    Shi Yi Zhou
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1158-64. 2008
    ..Hyperglycemia stimulates vagal afferents, which, in turn, activate vagal efferent cholinergic pathways synapsing with intragastric nitric oxide- and VIP-containing neurons to mediate gastric relaxation...
  99. ncbi The renal afferent pathways in the rat: a pseudorabies virus study
    M L Weiss
    Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506 5602, USA
    Brain Res 812:227-41. 1998
    ..Our results suggest that renal afferents travel in sympathetic and parasympathetic nerves and that this information may converge at the NTS...
  100. ncbi Innervation of the rat trachea by bilateral cholinergic projections from the nucleus ambiguus and direct motor fibers from the cervical spinal cord: a retrograde and anterograde tracer study
    Yasuro Atoji
    Laboratory of Veterinary Anatomy, Faculty of Applied Biological Sciences, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Brain Res 1031:90-100. 2005
    ..groups of rats: (1) ventral trachea, (2) lateral trachea, (3) ventral trachea after the excision of the nodose ganglion, and (4) ventral trachea after the transection of C1-C2 spinal nerves...
  101. ncbi TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence
    Otto Fajardo
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    J Neurosci 28:7863-75. 2008
    ..stimulation on intracellular calcium responses and excitability of cultured vagal sensory neurons in the rat nodose ganglion. A large fraction of vagal neurons were activated by cold, with a mean threshold of approximately 24 degrees ..

Research Grants71

  1. Functioning of Nodose Ganglia in Diabetes
    Chung Owyang; Fiscal Year: 2010
    ..This could provide important therapeutic targets and lead to improved management of diabetic patients with GI complications. ..
  2. CHEMORECEPTOR ACTIVITY OF THE CAROTID BODY
    Carlos Eyzaguirre; Fiscal Year: 1990
    ..synapses between sensory neurons and glomus cells and made by transplanting or apposing CB fragments to the nodose ganglion to take advantage of electrotonic spread from nerve terminals...
  3. NEUROANATOMY AND MOLECULAR BIOLOGY OF AIRWAY NEURONS
    RICHARD DEY; Fiscal Year: 1993
    ..The specific aims are to: determine if airway neurons are innervated by 1) sensory nerve fibers from the nodose ganglion or 2) postganglionic sympathetic nerve fibers from the superior cervical ganglion; 3) determine the airway ..
  4. CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 2003
    ..abstract_text> ..
  5. CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 2006
    ..abstract_text> ..
  6. CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 2005
    ..abstract_text> ..
  7. CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 2007
    ..abstract_text> ..
  8. CORTICOTROPIN-RELEASING FACTOR-ACTION ON GI FUNCTION
    YVETTE TACHE; Fiscal Year: 2004
    ..abstract_text> ..
  9. CHEMORECEPTION AND SIGNAL PROCESSING IN VAGAL AFFERENTS
    Daniel Weinreich; Fiscal Year: 1992
    ..and immunologically activated lung mast cells excite a subpopulation of visceral afferent neurons in the nodose ganglion of the rabbit by selectively blocking an unusually protracted spike afterhyperpolarization...
  10. CHEMORECEPTION AND SIGNAL PROCESSING IN VAGAL AFFERENTS
    Daniel Weinreich; Fiscal Year: 1991
    ..and immunologically activated lung mast cells excite a subpopulation of visceral afferent neurons in the nodose ganglion of the rabbit by selectively blocking an unusually protracted spike afterhyperpolarization...
  11. CHEMORECEPTION AND SIGNAL PROCESSING IN VAGAL AFFERENTS
    Daniel Weinreich; Fiscal Year: 1990
    ..and immunologically activated lung mast cells excite a subpopulation of visceral afferent neurons in the nodose ganglion of the rabbit by selectively blocking an unusually protracted spike afterhyperpolarization...
  12. OPIATE ACTIONS AND DEPENDENCE: SINGLE NEURON STUDIES
    R North; Fiscal Year: 1980
    ..recording in vitro from the myenteric plexus of the guinea-pig ileum, the vas deferens of the mouse and the nodose ganglion of the rat and guinea-pig...
  13. ESOPHAGEAL RECEPTOR REFLEXES: BRAINSTEM CIRCUITRY
    STEVEN ALTSCHULER; Fiscal Year: 1990
    ..the antidromic mapping technique will be used to determine the sites of projection and branching pattern of nodose ganglion neurons, having esophageal receptor endings that respond to stimuli which evoke crural inhibition...
  14. PULMONARY RECEPTOR ACTIVATION BY LUNG CONGESTION
    C Kappagoda; Fiscal Year: 1999
    ..identified on the basis of silver staining of myelinated axons, degenerative changes in the nerve endings following cervical vagotomy and the presence of diamines following injections of horse radish peroxidase into the nodose ganglion.
  15. MAST CELL-NERVE INTERACTIONS IN AIRWAYS
    Bradley Undem; Fiscal Year: 1993
    ..parasympathetic ganglions, and characteristics of the membrane properties of C-fibers neurons in the nodose ganglion. Additionally the function of the airway innervation of the airway will be studied by quantifying ..
  16. Mechanism of Glucose Sensing in Nodose ganglia in GI Motility
    Chung Owyang; Fiscal Year: 2007
    ....
  17. Mechanism of Glucose Sensing in Nodose ganglia in GI Motility
    Chung Owyang; Fiscal Year: 2010
    ....
  18. Mechanism of Glucose Sensing in Nodose ganglia in GI Motility
    Chung Owyang; Fiscal Year: 2009
    ....
  19. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth Kellar; Fiscal Year: 2007
    ..abstract_text> ..
  20. Molecular basis for activation of cardiovascular sensory afferents
    FRANCOIS ABBOUD; Fiscal Year: 2003
    ..abstract_text> ..
  21. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2003
    ..This should provide a comprehensive characterization of the neural components of the vagovagal circuit activated by secretin to effect gastric relaxation. ..
  22. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2002
    ..This should provide a comprehensive characterization of the neural components of the vagovagal circuit activated by secretin to effect gastric relaxation. ..
  23. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2004
    ..This should provide a comprehensive characterization of the neural components of the vagovagal circuit activated by secretin to effect gastric relaxation. ..
  24. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2001
    ..This should provide a comprehensive characterization of the neural components of the vagovagal circuit activated by secretin to effect gastric relaxation. ..
  25. SECRETIN AND GASTRIC MOTILITY
    Chung Owyang; Fiscal Year: 2000
    ..This should provide a comprehensive characterization of the neural components of the vagovagal circuit activated by secretin to effect gastric relaxation. ..
  26. Autoimmune Mechanisms of Diabetic Neuropathy
    John Wiley; Fiscal Year: 2009
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. . ..
  27. Autoimmune Mechanisms of Diabetic Neuropathy
    John Wiley; Fiscal Year: 2007
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. [unreadable] [unreadable]..
  28. Autoimmune Mechanisms of Diabetic Neuropathy
    John Wiley; Fiscal Year: 2006
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. [unreadable] [unreadable]..
  29. Autoimmune Mechanisms of Diabetic Neuropathy
    John Wiley; Fiscal Year: 2009
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. . ..
  30. Autoimmune Mechanisms of Diabetic Neuropathy
    John W Wiley; Fiscal Year: 2010
    ..Relevance to public health: These studies will lead to novel insights regarding the mechanistic basis of autoimmunity, autophagy and programmed cell death in the pathophysiology of diabetic neuropathy. . ..
  31. Dysfunction of Baroreceptor Neurons in Heart Failure: Cellular and Molecular Mech
    Yu Long Li; Fiscal Year: 2010
    ..The significance of these studies is to provide a new strategy to normalize the baroreflex dysfunction and to reduce mortality in CHF. ..
  32. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..Our second hypothesis is that the unique functional morphology of the occipital artery-nodose ganglion complex allows sustained increases in blood-borne factors to alter the synthesis of receptors in vagal ..
  33. Vagal afferent cell bodies as sensors of blood-borne factors
    Stephen Lewis; Fiscal Year: 2009
    ..Our second hypothesis is that the unique functional morphology of the occipital artery-nodose ganglion complex allows sustained increases in blood-borne factors to alter the synthesis of receptors in vagal ..
  34. Vagal afferent cell bodies as sensors of blood-borne factors
    Stephen Lewis; Fiscal Year: 2007
    ..Our second hypothesis is that the unique functional morphology of the occipital artery-nodose ganglion complex allows sustained increases in blood-borne factors to alter the synthesis of receptors in vagal ..
  35. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2003
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  36. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2005
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  37. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2002
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  38. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2002
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  39. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2001
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  40. ANALYSIS OF NOVEL HOMEOBOX GENES IN CARDIAC DEVELOPMENT
    Fabian Chen; Fiscal Year: 2004
    ..Lbx2, related to the ladybird genes important in Drosophila organogenesis, is strongly expressed in the nodose ganglion that develops to form the autonomic innervation of the heart...
  41. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  42. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2005
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  43. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2009
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  44. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2007
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  45. Acid-Sensing Ion Channels in Cardiac Ischemia
    Christopher Benson; Fiscal Year: 2006
    ..This work will provide new insights into the signals and sensors that respond to cardiac ischemia, and define new therapeutic targets and novel approaches for its treatment. ..
  46. NEUROHORMONAL MECHANISMS IN HYPERTENSION
    Carlos Ferrario; Fiscal Year: 1990
    ..2) the ability of Angs to alter the release of substance P, norepinephrine, and serotonin from DMM slices and nodose ganglion explants; 3) the transport mechanisms and functional significance of Ang binding sites in the DMM and ..
  47. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark Shapiro; Fiscal Year: 2009
    ..The elucidation of the mechanisms and functional role of AKAP79/150 in M-channel activity will shed light on how the nervous system functions in health and disease. ..
  48. Mechanism and functional role of AKAP79/150 in M current control and excitability
    Mark S Shapiro; Fiscal Year: 2010
    ..The elucidation of the mechanisms and functional role of AKAP79/150 in M-channel activity will shed light on how the nervous system functions in health and disease. ..
  49. Vagal Action of CCK in Mediating GI Function
    Chung Owyang; Fiscal Year: 2007
    ..Failure of this neural pathway may result in hyperphagia resulting in obesity. ..
  50. Vagal Action of CCK in Mediating GI Function
    Chung Owyang; Fiscal Year: 2005
    ..Failure of this neural pathway may result in hyperphagia resulting in obesity. ..
  51. Vagal Action of CCK in Mediating GI Function
    Chung Owyang; Fiscal Year: 2006
    ..Failure of this neural pathway may result in hyperphagia resulting in obesity. ..
  52. Vagal Action of CCK in Mediating GI Function
    Chung Owyang; Fiscal Year: 2004
    ..Failure of this neural pathway may result in hyperphagia resulting in obesity. ..
  53. Neurotrophins and Development of Baroreceptor Pathways
    Agnieszka Balkowiec; Fiscal Year: 2005
    ..This hypothesis, supported by our recently published data and preliminary studies, will be tested using nodose ganglion primary and second-order sensory neurons, as well as functionally homogenous primary and second-order neurons ..
  54. Neurotrophins and Development of Baroreceptor Pathways.
    Agnieszka Balkowiec; Fiscal Year: 2009
    ..This hypothesis, supported by our recently published data and preliminary studies, will be tested using nodose ganglion primary and second-order sensory neurons, as well as functionally homogenous primary and second-order neurons ..
  55. Neurotrophins and Development of Baroreceptor Pathways
    Agnieszka Balkowiec; Fiscal Year: 2009
    ..This hypothesis, supported by our recently published data and preliminary studies, will be tested using nodose ganglion primary and second-order sensory neurons, as well as functionally homogenous primary and second-order neurons ..
  56. Neurotrophins and Development of Baroreceptor Pathways.
    Agnieszka Balkowiec; Fiscal Year: 2006
    ..This hypothesis, supported by our recently published data and preliminary studies, will be tested using nodose ganglion primary and second-order sensory neurons, as well as functionally homogenous primary and second-order neurons ..
  57. Neurotrophins and Development of Baroreceptor Pathways
    Agnieszka Balkowiec; Fiscal Year: 2007
    ..This hypothesis, supported by our recently published data and preliminary studies, will be tested using nodose ganglion primary and second-order sensory neurons, as well as functionally homogenous primary and second-order neurons ..
  58. GASTROINTESTINAL INTEGRATION AND FEEDING
    Timothy Moran; Fiscal Year: 1999
    ..The dynamics of transpyloric flow to simultaneous microstructural analysis of food intake will be related. ..
  59. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2004
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  60. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2005
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  61. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2003
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  62. Cardiac Neuropathy in Type 1 Diabetic and Aging Mice
    Zixi Cheng; Fiscal Year: 2004
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the two motor nuclei, i.e., the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX)...
  63. Aging, Episodic Hypoxia, and Vagal Cardiac Projections.
    Zixi Cheng; Fiscal Year: 2004
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the motor neuron pools in the brainstem, i.e...
  64. Cardiac Neuropathy in Type 1 Diabetic and Aging
    Zixi Cheng; Fiscal Year: 2005
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the two motor nuclei, i.e., the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX)...
  65. Cardiac Neuropathy in Type 1 Diabetic and Aging
    Zixi Cheng; Fiscal Year: 2005
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the two motor nuclei, i.e., the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX)...
  66. Cardiac Neuropathy in Type 1 Diabetic and Aging
    Zixi Cheng; Fiscal Year: 2006
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the two motor nuclei, i.e., the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX)...
  67. Aging, Episodic Hypoxia, and Vagal Cardiac Projections.
    Zixi Cheng; Fiscal Year: 2006
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the motor neuron pools in the brainstem, i.e...
  68. Aging, Episodic Hypoxia, and Vagal Cardiac Projections.
    Zixi Cheng; Fiscal Year: 2007
    ..Vagal projections to the heart originate from a sensory ganglion, i.e., the nodose ganglion, and the motor neuron pools in the brainstem, i.e...