auditory cortex

Summary

Summary: Area of the temporal lobe concerned with hearing.

Top Publications

  1. ncbi Increased auditory cortical representation in musicians
    C Pantev
    Biomagnetism Center, Institute of Experimental Audiology, University of Munster, Germany
    Nature 392:811-4. 1998
  2. ncbi Sensitivity of newborn auditory cortex to the temporal structure of sounds
    Silke Telkemeyer
    Berlin NeuroImaging Center, Charite University Medicine, 10117 Berlin, Germany
    J Neurosci 29:14726-33. 2009
  3. ncbi Correlating stimulus-specific adaptation of cortical neurons and local field potentials in the awake rat
    Wolfger von der Behrens
    Institute for Cell Biology and Neuroscience, Department of Biological Sciences, Goethe University, Frankfurt am Main, Germany
    J Neurosci 29:13837-49. 2009
  4. ncbi Spectral interactions, but no mismatch negativity, in auditory cortex of anesthetized rat
    Ronit Lazar
    Department of Neurobiology and Behavior, University of California, Irvine, 2205 McGaugh Hall, Irvine, CA 92697, USA
    Hear Res 181:51-6. 2003
  5. ncbi Processing of low-probability sounds by cortical neurons
    Nachum Ulanovsky
    Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Nat Neurosci 6:391-8. 2003
  6. pmc Reconstructing speech from human auditory cortex
    Brian N Pasley
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 10:e1001251. 2012
  7. pmc Selective cortical representation of attended speaker in multi-talker speech perception
    Nima Mesgarani
    Departments of Neurological Surgery and Physiology, UCSF Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    Nature 485:233-6. 2012
  8. pmc Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC, USA
    Nat Neurosci 12:718-24. 2009
  9. ncbi The processing of temporal pitch and melody information in auditory cortex
    Roy D Patterson
    Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Neuron 36:767-76. 2002
  10. ncbi A disinhibitory microcircuit for associative fear learning in the auditory cortex
    Johannes J Letzkus
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 480:331-5. 2011

Detail Information

Publications351 found, 100 shown here

  1. ncbi Increased auditory cortical representation in musicians
    C Pantev
    Biomagnetism Center, Institute of Experimental Audiology, University of Munster, Germany
    Nature 392:811-4. 1998
    ....
  2. ncbi Sensitivity of newborn auditory cortex to the temporal structure of sounds
    Silke Telkemeyer
    Berlin NeuroImaging Center, Charite University Medicine, 10117 Berlin, Germany
    J Neurosci 29:14726-33. 2009
    ..That is, the newborn auditory cortex is sensitive to the temporal structure of the auditory input and shows an emerging tendency for functional ..
  3. ncbi Correlating stimulus-specific adaptation of cortical neurons and local field potentials in the awake rat
    Wolfger von der Behrens
    Institute for Cell Biology and Neuroscience, Department of Biological Sciences, Goethe University, Frankfurt am Main, Germany
    J Neurosci 29:13837-49. 2009
    ..Stimulus-specific adaptation (SSA) of single neurons in the auditory cortex has been proposed to be the cellular substrate of MMN (Nelken and Ulanovsky, 2007)...
  4. ncbi Spectral interactions, but no mismatch negativity, in auditory cortex of anesthetized rat
    Ronit Lazar
    Department of Neurobiology and Behavior, University of California, Irvine, 2205 McGaugh Hall, Irvine, CA 92697, USA
    Hear Res 181:51-6. 2003
    We used an 'oddball' stimulation paradigm to evoke epidural, event-related potentials over auditory cortex in urethane/xylazine-anesthetized rats, in order to study the neural mechanisms underlying the mismatch negativity (MMN)...
  5. ncbi Processing of low-probability sounds by cortical neurons
    Nachum Ulanovsky
    Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Nat Neurosci 6:391-8. 2003
    ..We report here that neurons in cat primary auditory cortex (A1) responded more strongly to a rarely presented sound than to the same sound when it was common...
  6. pmc Reconstructing speech from human auditory cortex
    Brian N Pasley
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 10:e1001251. 2012
    ..To address this question, we used intracranial recordings from nonprimary auditory cortex in the human superior temporal gyrus to determine what acoustic information in speech sounds can be ..
  7. pmc Selective cortical representation of attended speaker in multi-talker speech perception
    Nima Mesgarani
    Departments of Neurological Surgery and Physiology, UCSF Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    Nature 485:233-6. 2012
    ..listening task with two simultaneous speakers, we demonstrate that population responses in non-primary human auditory cortex encode critical features of attended speech: speech spectrograms reconstructed based on cortical responses to ..
  8. pmc Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC, USA
    Nat Neurosci 12:718-24. 2009
    ..Chief among these are physiological and anatomical studies showing that primate auditory cortex, across species, shows patterns of hierarchical structure, topographic mapping and streams of functional ..
  9. ncbi The processing of temporal pitch and melody information in auditory cortex
    Roy D Patterson
    Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Neuron 36:767-76. 2002
    ..The results support the view that there is hierarchy of pitch processing in which the center of activity moves anterolaterally away from primary auditory cortex as the processing of melodic sounds proceeds.
  10. ncbi A disinhibitory microcircuit for associative fear learning in the auditory cortex
    Johannes J Letzkus
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 480:331-5. 2011
    ..of associative fear memories depends on the recruitment of a disinhibitory microcircuit in the mouse auditory cortex. Fear-conditioning-associated disinhibition in auditory cortex is driven by foot-shock-mediated cholinergic ..
  11. pmc Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex
    Elsa van der Loo
    Brain Research centre Antwerp for Innovative and Interdisciplinary Neuromodulation BRAI 2 N, University Hospital Antwerp, Antwerp, Belgium
    PLoS ONE 4:e7396. 2009
    ..Tinnitus as a phantom phenomenon is related to hyperactivity and reorganization of the auditory cortex. Magnetoencephalography studies demonstrate a correlation between gamma band activity in the contralateral ..
  12. pmc Synaptic mechanisms of direction selectivity in primary auditory cortex
    Chang quan Ye
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 30:1861-8. 2010
    ..Although many neurons in the auditory cortex are known to be selective for FM direction, the synaptic mechanisms underlying this selectivity are not well ..
  13. ncbi Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
    Jonathan Fritz
    Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Neurosci 6:1216-23. 2003
    ..We recorded neuronal responses in the primary auditory cortex of behaving ferrets that were trained to detect a target tone of any frequency...
  14. ncbi How the brain separates sounds
    Robert P Carlyon
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Trends Cogn Sci 8:465-71. 2004
    ..Listeners' sensitivity to streaming cues can be captured in the responses of neurons in the primary auditory cortex, and in EEG wave components with a short latency (< 200ms)...
  15. pmc Stimulus-specific adaptation in the auditory thalamus of the anesthetized rat
    Flora M Antunes
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute of Neuroscience of Castilla y Leon, University of Salamanca, Salamanca, Spain
    PLoS ONE 5:e14071. 2010
    ..Previous studies have demonstrated that neurons in the auditory cortex and inferior colliculus show SSA...
  16. ncbi A synaptic memory trace for cortical receptive field plasticity
    Robert C Froemke
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA
    Nature 450:425-9. 2007
    ..Here we determine the dynamics of synaptic receptive field plasticity in the adult primary auditory cortex (also known as AI) using in vivo whole-cell recording...
  17. ncbi Spectral and temporal processing in human auditory cortex
    R J Zatorre
    Montreal Neurological Institute, McGill University, 3801 University St, Montreal, QC H3A 2B4, Canada
    Cereb Cortex 11:946-53. 2001
    We used positron emission tomography to examine the response of human auditory cortex to spectral and temporal variation...
  18. ncbi An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Inst, Orangeburg, New York 10962, USA
    J Neurophysiol 94:1904-11. 2005
    ..current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys...
  19. ncbi The mechanisms of tinnitus: perspectives from human functional neuroimaging
    Peyman Adjamian
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, United Kingdom
    Hear Res 253:15-31. 2009
    ....
  20. ncbi Multiple time scales of adaptation in auditory cortex neurons
    Nachum Ulanovsky
    Department of Neurobiology, The Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel
    J Neurosci 24:10440-53. 2004
    Neurons in primary auditory cortex (A1) of cats show strong stimulus-specific adaptation (SSA)...
  21. ncbi Visual activation of auditory cortex reflects maladaptive plasticity in cochlear implant users
    Pascale Sandmann
    Department of Psychology, Neuropsychology Lab, Carl von Ossietzky University of Oldenburg, Germany
    Brain 135:555-68. 2012
    Cross-modal reorganization in the auditory cortex has been reported in deaf individuals...
  22. pmc Robustness of cortical topography across fields, laminae, anesthetic states, and neurophysiological signal types
    Wei Guo
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 32:9159-72. 2012
    ..compared the strength of tonotopic organization at various depths within core and belt regions of the auditory cortex using electrophysiological measurements ranging from single units to delta-band local field potentials (LFP) ..
  23. pmc Developmental sensory experience balances cortical excitation and inhibition
    Anja L Dorrn
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, and NeuroCure Neuroscience Research Center NWFZ, Berlin 13125, Germany
    Nature 465:932-6. 2010
    Early in life, neural circuits are highly susceptible to outside influences. The organization of the primary auditory cortex (A1) in particular is governed by acoustic experience during the critical period, an epoch near the beginning of ..
  24. ncbi Auditory cortex is implicated in tinnitus distress: a voxel-based morphometry study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    Brain Struct Funct 218:1061-70. 2013
    ..Our results support the notion that the role of the auditory cortex in tinnitus is not restricted to perceptual aspects...
  25. pmc Laminar structure of spontaneous and sensory-evoked population activity in auditory cortex
    Shuzo Sakata
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 64:404-18. 2009
    ..cells, we compare the laminar structure of spontaneous and sensory-evoked population activity in rat auditory cortex. Spontaneous and evoked patterns both exhibited sparse, spatially localized activity in layer 2/3 pyramidal ..
  26. ncbi "Sparse" temporal sampling in auditory fMRI
    D A Hall
    MRC Institute of Hearing Research, Nottingham, UK
    Hum Brain Mapp 7:213-23. 1999
    ..g., attentive effort) induced by the intense background noise. We suggest that sparse imaging is advantageous in auditory experiments as it ensures that the obtained activation depends on the stimulus alone...
  27. pmc Residual inhibition functions overlap tinnitus spectra and the region of auditory threshold shift
    Larry E Roberts
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1
    J Assoc Res Otolaryngol 9:417-35. 2008
    ..Animals exposed to noise trauma show augmented synchronous neural activity in tonotopically reorganized primary auditory cortex consequent on hearing loss...
  28. ncbi Visual modulation of neurons in auditory cortex
    Christoph Kayser
    Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tubingen, Germany
    Cereb Cortex 18:1560-74. 2008
    ..These results demonstrate that visual stimuli can modulate the firing of neurons in auditory cortex in a manner that depends on stimulus efficacy and timing...
  29. pmc Mechanisms and streams for processing of "what" and "where" in auditory cortex
    J P Rauschecker
    Georgetown Institute for Cognitive and Computational Sciences, Georgetown University Medical Center, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 97:11800-6. 2000
    The functional specialization and hierarchical organization of multiple areas in rhesus monkey auditory cortex were examined with various types of complex sounds...
  30. pmc Phase patterns of neuronal responses reliably discriminate speech in human auditory cortex
    Huan Luo
    Neuroscience and Cognitive Science Program, Department of Biology, University of Maryland College Park, College Park, MD 20742, USA
    Neuron 54:1001-10. 2007
    How natural speech is represented in the auditory cortex constitutes a major challenge for cognitive neuroscience...
  31. ncbi Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained
    Patrick J C May
    Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Espoo, Finland
    Psychophysiology 47:66-122. 2010
    ..We propose that the MMN is, in essence, a latency- and amplitude-modulated expression of the auditory N1 response, generated by fresh-afferent activity of cortical neurons that are under nonuniform levels of adaptation...
  32. ncbi Human primary auditory cortex follows the shape of Heschl's gyrus
    Sandra Da Costa
    Neuropsychology and Neurorehabilitation Service, Lausanne University Hospital CHUV, Switzerland
    J Neurosci 31:14067-75. 2011
    The primary auditory cortex (PAC) is central to human auditory abilities, yet its location in the brain remains unclear...
  33. ncbi "Who" is saying "what"? Brain-based decoding of human voice and speech
    Elia Formisano
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, University of Maastricht, 6200 MD Maastricht, Netherlands
    Science 322:970-3. 2008
    ..a person is listening to from the neural fingerprints that speech and voice signals elicit in the listener's auditory cortex. These cortical fingerprints are spatially distributed and insensitive to acoustic variations of the input so ..
  34. pmc Preceding inhibition silences layer 6 neurons in auditory cortex
    Yi Zhou
    Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Neuron 65:706-17. 2010
    ..Here, cell-attached recordings in rat primary auditory cortex revealed that for the majority of L6 excitatory neurons, tonal stimuli did not drive spike responses, but ..
  35. pmc Interactions between the superior temporal sulcus and auditory cortex mediate dynamic face/voice integration in rhesus monkeys
    Asif A Ghazanfar
    Neuroscience Institute and Department of Psychology, Princeton University, Princeton, New Jersey 08540, USA
    J Neurosci 28:4457-69. 2008
    ..To test the hypothesis that multisensory responses in auditory cortex are influenced by visual inputs from the superior temporal sulcus (STS), an association area, we recorded ..
  36. pmc Attention-driven auditory cortex short-term plasticity helps segregate relevant sounds from noise
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 108:4182-7. 2011
    ..In conclusion, a simple gain model alone cannot explain auditory selective attention. In nonprimary auditory cortices, attention-driven short-term plasticity retunes neurons to segregate relevant sounds from noise...
  37. ncbi Dynamics of precise spike timing in primary auditory cortex
    Mounya Elhilali
    Institute for Systems Research, Department of Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 24:1159-72. 2004
    Although single units in primary auditory cortex (A1) exhibit accurate timing in their phasic response to the onset of sound (precision of a few milliseconds), paradoxically, they are unable to sustain synchronized responses to repeated ..
  38. pmc Spatial and temporal processing of single auditory cortical neurons and populations of neurons in the macaque monkey
    Gregg H Recanzone
    Center for Neuroscience, Department of Neurobiology, Physiology and Behavior, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Hear Res 271:115-22. 2011
    The auditory cortex is known to be a necessary neural structure for the perception of acoustic signals, particularly the spatial location and the temporal features of complex auditory stimuli...
  39. pmc Projections to the inferior colliculus from layer VI cells of auditory cortex
    B R Schofield
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272, USA
    Neuroscience 159:246-58. 2009
    ..a retrograde tracer into the inferior colliculus of guinea pigs labeled two bands of cells in the ipsilateral auditory cortex: a dense band of cells in layer V and a second band of cells in layer VI...
  40. ncbi Sensory-motor interaction in the primate auditory cortex during self-initiated vocalizations
    Steven J Eliades
    Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurophysiol 89:2194-207. 2003
    Little is known about sensory-motor interaction in the auditory cortex of primates at the level of single neurons and its role in supporting vocal communication...
  41. ncbi Functional organization and population dynamics in the mouse primary auditory cortex
    Gideon Rothschild
    Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Nat Neurosci 13:353-60. 2010
    ..However, the functional organization and dynamics of local populations in the auditory cortex have remained largely unknown...
  42. ncbi Human primary auditory cortex: cytoarchitectonic subdivisions and mapping into a spatial reference system
    P Morosan
    Institute of Medicine, , Germany
    Neuroimage 13:684-701. 2001
    The transverse temporal gyrus of Heschl contains the human auditory cortex. Several schematic maps of the cytoarchitectonic correlate of this functional entity are available, but they present partly conflicting data (number and position ..
  43. ncbi Precise inhibition is essential for microsecond interaural time difference coding
    Antje Brand
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Nature 417:543-7. 2002
    ..A computer model, simulating the response of a coincidence-detector neuron with bilateral excitatory inputs and a temporally precise contralateral inhibitory input, supports this conclusion...
  44. ncbi Synaptic mechanisms of forward suppression in rat auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 47:437-45. 2005
    In the auditory cortex, brief sounds elicit a powerful suppression of responsiveness that can persist for hundreds of milliseconds...
  45. pmc Homeostatic plasticity drives tinnitus perception in an animal model
    Sungchil Yang
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 108:14974-9. 2011
    ..Enhancing sensory input through map reorganization may plausibly alleviate phantom sensation...
  46. ncbi Timbre-specific enhancement of auditory cortical representations in musicians
    C Pantev
    Biomagnetism Center, Institute for Experimental Audiology, , Germany
    Neuroreport 12:169-74. 2001
    ..Timbre specificity is predicted by a principle of use-dependent plasticity and imposes new requirements on nativistic accounts of brain attributes associated with musical skill...
  47. ncbi Activation of auditory cortex during silent lipreading
    G A Calvert
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Science 276:593-6. 1997
    ..magnetic resonance imaging it was found that these linguistic visual cues are sufficient to activate auditory cortex in normal hearing individuals in the absence of auditory speech sounds...
  48. pmc Auditory cortex tracks both auditory and visual stimulus dynamics using low-frequency neuronal phase modulation
    Huan Luo
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    PLoS Biol 8:e1000445. 2010
    ....
  49. ncbi Auditory cortex on the human posterior superior temporal gyrus
    M A Howard
    Department of Surgery Division of Neurosurgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Comp Neurol 416:79-92. 2000
    ..These physiological findings are in accord with anatomic evidence in humans and in nonhuman primates that the superior temporal cortex contains multiple interconnected auditory areas...
  50. pmc Motor-induced suppression of the auditory cortex
    Sheye O Aliu
    University of California San Francisco, USA
    J Cogn Neurosci 21:791-802. 2009
    ..In three MEG experiments, we characterize the properties of MIS by examining the M100 response from the auditory cortex to a simple tone triggered by a button press...
  51. pmc Temporal predictive codes for spoken words in auditory cortex
    Pierre Gagnepain
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Biol 22:615-21. 2012
    ..This prediction error signal explains the efficiency of human word recognition and simulates neural responses in auditory regions...
  52. ncbi Tuning for spectro-temporal modulations as a mechanism for auditory discrimination of natural sounds
    Sarah M N Woolley
    Helen Wills Neuroscience Institute and Department of Psychology, University of California at Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 8:1371-9. 2005
    ..Additionally, auditory neurons discriminate among zebra finch song segments better than among synthetic sound segments...
  53. pmc Sparse representation of sounds in the unanesthetized auditory cortex
    Tomás Hromádka
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York, United States of America
    PLoS Biol 6:e16. 2008
    How do neuronal populations in the auditory cortex represent acoustic stimuli? Although sound-evoked neural responses in the anesthetized auditory cortex are mainly transient, recent experiments in the unanesthetized preparation have ..
  54. pmc Multiplexed and robust representations of sound features in auditory cortex
    Kerry M M Walker
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    J Neurosci 31:14565-76. 2011
    ..In this study, we investigate whether neurons in both core and belt areas of ferret auditory cortex can robustly represent the pitch, formant frequencies, or azimuthal location of artificial vowel sounds while ..
  55. ncbi Auditory cortex activation is modulated by emotion: a functional near-infrared spectroscopy (fNIRS) study
    M M Plichta
    Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 55:1200-7. 2011
    ..Pleasant and unpleasant sounds led to increased auditory cortex activation as compared to neutral sounds...
  56. pmc The spectrotemporal filter mechanism of auditory selective attention
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Neuron 77:750-61. 2013
    ..evidence that attention to auditory stimuli modulates neuronal responses at or before the level of primary auditory cortex (A1), the underlying physiological mechanisms are unknown...
  57. pmc Cortical activity patterns predict robust speech discrimination ability in noise
    Jai A Shetake
    The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41 Richardson, TX 75080 3021, USA
    Eur J Neurosci 34:1823-38. 2011
    ..We tested speech sound discrimination in rats and recorded primary auditory cortex (A1) responses to speech sounds in background noise of different intensities and spectral compositions...
  58. ncbi Physiological and anatomical evidence for multisensory interactions in auditory cortex
    Jennifer K Bizley
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Cereb Cortex 17:2172-89. 2007
    ..recordings and estimates of mutual information that visual stimuli can influence the activity of units in the auditory cortex of anesthetized ferrets...
  59. ncbi Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval
    D C Javitt
    Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg 10962, USA
    Electroencephalogr Clin Neurophysiol 108:143-53. 1998
    ..The pattern of deficit observed in schizophrenia differs from the pattern observed in other conditions associated with MMN dysfunction, including Alzheimer's disease, stroke, and alcohol intoxication...
  60. ncbi Learning-stage-dependent, field-specific, map plasticity in the rat auditory cortex during appetitive operant conditioning
    H Takahashi
    Research Center for Advanced Science and Technology, The University of Tokyo, Komaba 4 6 1, Meguro ku, Tokyo 153 8904, Japan
    Neuroscience 199:243-58. 2011
    ..In the present study, microelectrode mapping characterized plasticity in the rat auditory cortex, including primary, anterior, and ventral/suprarhinal auditory fields (A1, AAF, and VAF/SRAF), at the early ..
  61. ncbi Non-sensory cortical and subcortical connections of the primary auditory cortex in Mongolian gerbils: bottom-up and top-down processing of neuronal information via field AI
    Eike Budinger
    Leibniz Institute for Neurobiology, Department of Auditory Learning and Speech, Brenneckestrasse 6, D 39118 Magdeburg, Germany
    Brain Res 1220:2-32. 2008
    In the present study, we will provide further anatomical evidence that the primary auditory cortex (field AI) is not only involved in sensory processing of its own modality, but also in complex bottom-up and top-down processing of ..
  62. pmc GABA shapes selectivity for the rate and direction of frequency-modulated sweeps in the auditory cortex
    Khaleel A Razak
    Department 3166, Zoology and Physiology, University of Wyoming, 1000 E University Ave, Laramie, WY 82071, USA
    J Neurophysiol 102:1366-78. 2009
    In the pallid bat auditory cortex and inferior colliculus (IC), the majority of neurons tuned in the echolocation range is selective for the direction and rate of frequency-modulated (FM) sweeps used in echolocation...
  63. ncbi Activity associated with stream segregation in human auditory cortex is similar for spatial and pitch cues
    Stefan Schadwinkel
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Cereb Cortex 20:2863-73. 2010
    ..and potential neural correlates for streaming based on spectral and pitch cues have been identified in the auditory cortex. Here, magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) were used to evaluate if ..
  64. ncbi Suppressed responses to self-triggered sounds in the human auditory cortex
    Mika H Martikainen
    Department of Clinical Neurophysiology, Helsinki University Central Hospital, FIN 00290 Helsinki, Finland
    Cereb Cortex 15:299-302. 2005
    ..Here we tested whether responses in the human auditory cortex would differ to self-triggered versus externally triggered tones...
  65. ncbi Effect of auditory cortex deactivation on stimulus-specific adaptation in the medial geniculate body
    Flora M Antunes
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute of Neuroscience of Castilla y Leon, Calle Pintor Fernando Gallego, 1, Spain
    J Neurosci 31:17306-16. 2011
    ..In the auditory system, SSA has been identified in the midbrain, thalamus, and auditory cortex (AC)...
  66. ncbi Visual enhancement of the information representation in auditory cortex
    Christoph Kayser
    Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076 Tubingen, Germany
    Curr Biol 20:19-24. 2010
    ..By recording in auditory cortex of alert monkeys watching naturalistic audiovisual stimuli, we quantified the effect of visual influences on ..
  67. pmc Functional connectivity and cholinergic modulation in auditory cortex
    Raju Metherate
    Department of Neurobiology and Behavior, Center for Hearing Research, University of California Irvine, CA 92697 4550, United States
    Neurosci Biobehav Rev 35:2058-63. 2011
    Although it is known that primary auditory cortex (A1) contributes to the processing and perception of sound, its precise functions and the underlying mechanisms are not well understood...
  68. pmc Contrast gain control in auditory cortex
    Neil C Rabinowitz
    Department of Physiology, Anatomy, and Genetics, Sherrington Building, Parks Road, University of Oxford, Oxford OX13PT, UK
    Neuron 70:1178-91. 2011
    ..We show that neurons in ferret auditory cortex rescale their gain to partially compensate for the spectrotemporal contrast of recent stimulation...
  69. ncbi Tone-evoked excitatory and inhibitory synaptic conductances of primary auditory cortex neurons
    Andrew Y Y Tan
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
    J Neurophysiol 92:630-43. 2004
    In primary auditory cortex (AI) neurons, tones typically evoke a brief depolarization, which can lead to spiking, followed by a long-lasting hyperpolarization...
  70. ncbi Morphology of Heschl's gyrus reflects enhanced activation in the auditory cortex of musicians
    Peter Schneider
    Department of Physics, University of Heidelberg, Philosophenweg 12, D 69120 Heidelberg, Germany
    Nat Neurosci 5:688-94. 2002
    Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians...
  71. ncbi Mirror-symmetric tonotopic maps in human primary auditory cortex
    Elia Formisano
    Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Postbus 616, 6200MD Maastricht, The Netherlands
    Neuron 40:859-69. 2003
    Understanding the functional organization of the human primary auditory cortex (PAC) is an essential step in elucidating the neural mechanisms underlying the perception of sound, including speech and music...
  72. ncbi Changes in spontaneous firing rate and neural synchrony in cat primary auditory cortex after localized tone-induced hearing loss
    Satoshi Seki
    Departments of Physiology and Biophysics, and Psychology, University of Calgary, 2500 University Drive N W, Calgary, AB, Canada T2N 1N4
    Hear Res 180:28-38. 2003
    ..The frequency representation in primary auditory cortex was mapped using an eight-electrode array. Single-unit spontaneous activity was recorded for 15 min...
  73. ncbi Topography and synaptic shaping of direction selectivity in primary auditory cortex
    Li I Zhang
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    Nature 424:201-5. 2003
    ..FM direction-selective neurons are found in the primary auditory cortex (A1), but their topography and the mechanisms underlying their selectivity remain largely unknown...
  74. pmc Repetition suppression and plasticity in the human brain
    Marta I Garrido
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
    Neuroimage 48:269-79. 2009
    ..It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG...
  75. pmc Lateral sharpening of cortical frequency tuning by approximately balanced inhibition
    Guangying K Wu
    Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA
    Neuron 58:132-43. 2008
    ..Here, in vivo whole-cell recordings from neurons in the rat primary auditory cortex revealed that the frequency tuning curve of inhibitory input was broader than that of excitatory input...
  76. ncbi Redefining the tonotopic core of rat auditory cortex: physiological evidence for a posterior field
    Neot N Doron
    W M Keck Laboratories of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 453:345-60. 2002
    ..Finally, the physiological data suggest that core auditory cortex (temporal area TE1) is composed not only of AI as previously thought, but also of at least two other ..
  77. pmc Neural activity in speech-sensitive auditory cortex during silence
    M D Hunter
    Sheffield Cognition and Neuroimaging Laboratory SCANLab, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Sheffield S5 7JT, United Kingdom
    Proc Natl Acad Sci U S A 103:189-94. 2006
    ..heard in the absence of external stimuli implies the existence of endogenous neural activity within the auditory cortex responsible for their perception...
  78. pmc Early auditory experience generates long-lasting memories that may subserve vocal learning in songbirds
    Mimi L Phan
    Department of Psychology, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:1088-93. 2006
    ..Furthermore, the strength of this selectivity shows a striking correlation with the fidelity of vocal imitation, suggesting that this auditory memory may have served as the model for song learning...
  79. pmc Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity
    Hidehiko Okamoto
    Institute for Biomagnetism and Biosignalanalysis, Westfalian Wilhelms University, Malmedyweg 15, Muenster, Germany
    Proc Natl Acad Sci U S A 107:1207-10. 2010
    Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus...
  80. ncbi Auditory plasticity and hyperactivity following cochlear damage
    R J Salvi
    Hearing Research Lab, University of Buffalo, 215 Parker Hall, Buffalo, NY 14214, USA
    Hear Res 147:261-74. 2000
    ..of IHC loss, the IC response shows only a modest amplitude reduction, and remarkably, the response of the auditory cortex is enhanced...
  81. pmc Encoding of learned importance of sound by magnitude of representational area in primary auditory cortex
    Richard G Rutkowski
    Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 102:13664-9. 2005
    We hypothesized that learning-induced representational expansion in the primary auditory cortex (AI) directly encodes the degree of behavioral importance of a sound...
  82. ncbi Birdsong memory: a neural dissociation between song recognition and production
    Sharon M H Gobes
    Behavioural Biology and Helmholtz Institute, Utrecht University, Padualaan 8, P O Box 80086, 3508 TB Utrecht, The Netherlands
    Curr Biol 17:789-93. 2007
    ..Thus, in both humans and songbirds, the cognitive systems of vocal production and auditory recognition memory are subserved by distinct brain regions...
  83. pmc Cortical representation of natural complex sounds: effects of acoustic features and auditory object category
    Amber M Leaver
    Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 30:7604-12. 2010
    ..sounds are thought to be represented by neurons responding to increasing degrees of complexity throughout auditory cortex, with complete auditory "objects" encoded by neurons (or small networks of neurons) in anterior superior ..
  84. ncbi Binary spiking in auditory cortex
    Michael R Deweese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 23:7940-9. 2003
    ..We have, therefore, assessed trial-to-trial variability in the auditory cortex of the rat. To ensure single-unit isolation, we used cell-attached recording...
  85. ncbi Cross-modal plasticity in specific auditory cortices underlies visual compensations in the deaf
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Nat Neurosci 13:1421-7. 2010
    ..In the absence of acoustic input, it has been proposed that cross-modal reorganization of deaf auditory cortex may provide the neural substrate mediating compensatory visual function...
  86. pmc Stimulus-specific adaptation and deviance detection in the rat auditory cortex
    Nevo Taaseh
    Department of Neurobiology, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel
    PLoS ONE 6:e23369. 2011
    ..We studied SSA in the auditory cortex of halothane-anesthetized rats, recording local field potentials and multi-unit activity...
  87. ncbi Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations
    Theda H Heinks-Maldonado
    Department of Neuropsychology, Albert Ludwigs Universitat, Freiburg, Germany
    Arch Gen Psychiatry 64:286-96. 2007
    ..Imprecision of the corollary discharge in schizophrenia may contribute to the misperception of inner experiences and thoughts as "voices" or auditory hallucinations...
  88. ncbi Prior expectation mediates neural adaptation to repeated sounds in the auditory cortex: an MEG study
    Ana Todorović
    Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Neurosci 31:9118-23. 2011
    ..We found robust repetition suppression in the auditory cortex for repeated tones...
  89. ncbi Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 426:442-6. 2003
    Neurons in the primary auditory cortex are tuned to the intensity and specific frequencies of sounds, but the synaptic mechanisms underlying this tuning remain uncertain...
  90. ncbi Sound categories are represented as distributed patterns in the human auditory cortex
    Noel Staeren
    Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Curr Biol 19:498-502. 2009
    ....
  91. pmc Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development
    Yujiao J Sun
    Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nature 465:927-31. 2010
    ..Here we apply in vivo whole-cell voltage-clamp recordings to the recipient layer 4 neurons in the rat primary auditory cortex (A1) to determine the developmental changes in the frequency-intensity tonal receptive fields (TRFs) of their ..
  92. pmc Rapid synaptic depression explains nonlinear modulation of spectro-temporal tuning in primary auditory cortex by natural stimuli
    Stephen V David
    Institute for Systems Research, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 29:3374-86. 2009
    In this study, we explored ways to account more accurately for responses of neurons in primary auditory cortex (A1) to natural sounds...
  93. ncbi Perceptual organization of tone sequences in the auditory cortex of awake macaques
    Christophe Micheyl
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 48:139-48. 2005
    ..formation measured in humans using alternating-tone sequences can be quantitatively accounted for based on single-unit responses recorded in the primary auditory cortex (A1) of awake rhesus monkeys listening to the same sound sequences.
  94. ncbi Perceptual learning directs auditory cortical map reorganization through top-down influences
    Daniel B Polley
    W M Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143 0732, USA
    J Neurosci 26:4970-82. 2006
    ..We tested whether topographic map plasticity in the adult primary auditory cortex and a secondary auditory area, the suprarhinal auditory field, was controlled by the statistics of bottom-up ..
  95. ncbi Temporal and rate representations of time-varying signals in the auditory cortex of awake primates
    T Lu
    Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 424, Baltimore, Maryland 21205, USA
    Nat Neurosci 4:1131-8. 2001
    ..Here we show that there are two largely distinct populations of neurons in the auditory cortex of awake primates: one with stimulus-synchronized discharges that, with a temporal code, explicitly ..
  96. ncbi Altered low-γ sampling in auditory cortex accounts for the three main facets of dyslexia
    Katia Lehongre
    Inserm U960 École Normale Supérieure, 75005 Paris, France
    Neuron 72:1080-90. 2011
    ..bias for phonemic processing, reflected in less entrainment to ≈30 Hz acoustic modulations in left auditory cortex. This deficit correlates with measures of phonological processing and rapid naming...
  97. pmc Neuronal representations of distance in human auditory cortex
    Norbert Kopco
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 109:11019-24. 2012
    ....
  98. pmc Altered cross-modal processing in the primary auditory cortex of congenitally deaf adults: a visual-somatosensory fMRI study with a double-flash illusion
    Christina M Karns
    Department of Psychology and Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    J Neurosci 32:9626-38. 2012
    ..cross-modal neuroplasticity in anatomically defined subregions of Heschl's gyrus, the site of human primary auditory cortex, in congenitally deaf humans by measuring the fMRI signal change in response to spatially coregistered visual,..
  99. pmc Evidence for opponent-channel coding of interaural time differences in human auditory cortex
    David A Magezi
    MRC Institute of Hearing Research, University Park, Nottingham, NG7 2RD, UK
    J Neurophysiol 104:1997-2007. 2010
    ..The hemispheric distributions of the ITD change responses suggest that the majority of ITD-sensitive neurons in each hemisphere are tuned to ITDs from the contralateral hemifield...
  100. ncbi Neurons with stereotyped and rapid responses provide a reference frame for relative temporal coding in primate auditory cortex
    Romain Brasselet
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    J Neurosci 32:2998-3008. 2012
    ..Studying the encoding of naturalistic sounds in primate (Macaca mulatta) auditory cortex we here investigate potential intrinsic references for decoding temporally precise information...
  101. ncbi Cortical map plasticity improves learning but is not necessary for improved performance
    Amanda Reed
    School of Behavioral and Brain Sciences, GR41, The University of Texas at Dallas, Richardson, TX 75080 3021, USA
    Neuron 70:121-31. 2011
    ..in perceptual ability after pairing tones with stimulation of the cholinergic nucleus basalis to induce auditory cortex map plasticity outside of a behavioral context...

Research Grants78

  1. CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS
    Donald M Caspary; Fiscal Year: 2013
    ..in GABA- and glycinergic inhibitory pharmacology and physiology in the dorsal cochlear nucleus and primary auditory cortex. Proposal studies will examine the nature of GABAA receptors (GABAARs) at the level of the medial geniculate ..
  2. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..touches on the face (which are normally processed in an adjacent area of somatosensory cortex), the areas of auditory cortex affected by hearing loss start responding to hearing-loss edge frequencies...
  3. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..We will use in vitro models of the primary auditory cortex, with gamma oscillations induced using the glutamatergic agonist kainate or the cholinergic agonist carbachol...
  4. Auditory Cortex Plasticity and Tinnitus
    Brian Allman; Fiscal Year: 2012
    ..intramodal cortical plasticity), and in the case of profound deafness caused by ototoxicity, neurons in the auditory cortex becoming responsive to somatosensory stimulation (i.e., crossmodal cortical plasticity)...
  5. Effectiveness of Therapy via Telemedicine following Cochlear Implants
    Anu Sharma; Fiscal Year: 2013
    ..nerve, allowing auditory input to circumvent damaged hair cells in the cochlea, and hence to stimulate the auditory cortex. CI can facilitate normal speech/language development during the first 3...
  6. Synaptic basis of perceptual learning in primary auditory cortex
    ROBERT CROOKS FROEMKE; Fiscal Year: 2013
    ..This plasticity is essential for learning and memory, and is an important feature of the auditory cortex, especially for learning the significance of sensory signals such as speech, for the use of devices such as ..
  7. Cholinergic inputs to excitatory and inhibitory midbrain auditory circuits
    JEFFREY GARRETT MELLOTT; Fiscal Year: 2013
    ..Descending projections from auditory cortex to the inferior colliculus of the midbrain play a role in a wide range of auditory functions, including ..
  8. Cross-modal re-organization in children with cochlear implants
    Julia Dee Campbell; Fiscal Year: 2013
    ..Indeed, cases of visual-to-auditory cross-modal re-organization (visual cortical recruitment via auditory cortex) have been found via high-density electroencephalography (EEG) recordings in adults who received cochlear ..
  9. Anatomical analysis of cortical projections to the auditory midbrain
    KYLE TOKUICHI NAKAMOTO; Fiscal Year: 2012
    ..The auditory cortex is the source of massive descending projections that are considered to play a role in a wide range of ..
  10. Electrophysiological mapping of corticocollicular projections involved with tonot
    HUBERT HYUNGIL LIM; Fiscal Year: 2013
    ..electrophysiological techniques to map out the functional and anatomical projection patterns from the primary auditory cortex (A1) to the central nucleus of the inferior colliculus (ICC)...
  11. FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEX
    Christoph E Schreiner; Fiscal Year: 2013
    ..We attempt to explore the normal function of the auditory cortex for processing complex signals and signals in different types of background noise in order to ascertain the ..
  12. Auditory Cortex: Synaptic organization and plasticity
    Paul B Manis; Fiscal Year: 2013
    ..we will explore local circuit organization within and orthogonal to the tonotopic axes of the primary auditory cortex, the mechanisms regulating synaptic plasticity in those circuits, and the effects of hearing loss on circuit ..
  13. Integration of ascending and descending input to auditory cortex
    Matthew I Banks; Fiscal Year: 2013
    ..Here, we propose to investigate the cellular and circuit mechanisms of this integrative process in auditory cortex and its modulation by general anesthetics...
  14. AUDITORY MEMORIES AND VOCAL LEARNING
    Frederic E Theunissen; Fiscal Year: 2013
    ..we have characterized responses in the avian auditory midbrain, thalamus and in the primary and secondary auditory cortex. We have shown that auditory neurons are specialized to represent natural sounds and that we can explain this ..
  15. The Impact of Frequency Compression on Cortical Evoked Potentials and Perception
    Benjamin J Kirby; Fiscal Year: 2013
    ..been established that cortical auditory evoked potentials (CAEPs), objective recordings of activity in the auditory cortex, may serve as an alternative to parental report for fitting hearing aids...
  16. Cortical Responses to Cochlear Implant Stimulation
    LUKE AARON JOHNSON; Fiscal Year: 2012
    ..Its hearing range is similar to that of humans and its auditory cortex shares similar organizations as humans, making it a valuable model to address issues in CI research ..
  17. The effects of aging and hearing loss on human auditory cortex
    David L Woods; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human auditory cortex (HAC) is a complex area that contains multiple, functionally specialized auditory cortical fields (ACFs)...
  18. Epigenetics of neuronal plasticity in auditory cortex in a sensory memory model
    Kerry J Ressler; Fiscal Year: 2013
    ..auditory learning and memory, behavioral and electrophysiological evidence point to a key role played by the auditory cortex, but the molecular mechanisms operating there to enable memory formation and maintenance are unknown...
  19. Parsing the schizophrenia-bipolar spectrum: an MEG based schizoaffective endophen
    Martin Reite; Fiscal Year: 2010
    ..status of GABAergic interneuronal activity regulating firing patterns of layer 3 pyramidal cells in auditory cortex of Heschl's gyrus...
  20. Contributions of peripheral spatial resolution to speech perception in CI users
    Rachel A Scheperle; Fiscal Year: 2013
    ..resolution (ECAP forward masking), we propose using two electrophysiological measures of processing at the auditory cortex: a measure of spatial resolution (discrimination between two electrodes) and a measure of spectral resolution ..
  21. Towards understanding cellular mechanisms of positive symptoms of schizophrenia
    Stanislav S Zakharenko; Fiscal Year: 2013
    ..of 22q11DS have substantial deficits in synaptic transmission and short-term plasticity at TC pathways to the auditory cortex. In this proposal, we will use single-cell electrophysiology, 2-photon imaging, 2-photon glutamate uncaging, ..
  22. Amygdalar modulation of processing in auditory cortex
    DIANA COOMES PETERSON; Fiscal Year: 2012
    ..processes the emotional significance of sensory stimuli) influences the processing of auditory information in auditory cortex (AC). Individuals/animals pay more attention to significant versus insignificant stimuli...
  23. Somatosensory-to-auditory cross-modal plasticity in cochlear implanted children
    GARRETT JOSEPH CARDON; Fiscal Year: 2013
    ..have demonstrated convincing evidence in both animals and humans that the visual system can recruit the auditory cortex in deafness...
  24. Rescue of cortical inhibitory synapses following developmental hearing loss
    DAN HARVEY SANES; Fiscal Year: 2013
    ..related aims: Aim 1 will first determine whether the effect of developmental conductive hearing loss (CHL) on auditory cortex inhibitory synapse function persists into adulthood...
  25. Neural Correlates of Streaming of Complex Sounds
    Shihab A Shamma; Fiscal Year: 2013
    ..Neural responses to sound streams will be measured in different fields of the ferret auditory cortex (spanning both primary or "core" and secondary or "belt" areas) under different attentional conditions, ..
  26. Behavioral and physiological studies of sound localization
    Tom C T Yin; Fiscal Year: 2013
    ..The other circuit involves projections from the inferior colliculus to the medial geniculate and primary auditory cortex. By inactivating the cortex or the midbrain, the relative roles of these two circuits in orienting behavior ..
  27. Information Processing in Auditory Cortex
    Xiaoqin Wang; Fiscal Year: 2013
    ..both neural mechanisms for processing communication sounds and fundamental neural coding mechanisms in auditory cortex that subserve cortical representations of biologically relevant sounds...
  28. Pilot Clinical Trial of Deep Brain Stimulation for Tinnitus
    Paul Larson; Fiscal Year: 2013
    ..such as hearing aids, neurobehavioral sound extinction procedures, and magnetic or electrical stimulation of auditory cortex. Those tinnitus sufferers have little therapeutic recourse...
  29. Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
    Mesut Sahin; Fiscal Year: 2012
    ..locomotion or micturition in spinal cord injury, microstimulation of the cochlear nucleus, midbrain, or auditory cortex to restore hearing, and stimulation of the visual cortex in the blind subjects...
  30. Functions of Associative Auditory Cortical Plasticity
    Norman M Weinberger; Fiscal Year: 2013
    ..The rich and complex domain of auditory memory is enabled by the plasticity of the auditory cortex. For example, learning is accompanied by shifts of frequency tuning to emphasize sounds that become ..
  31. Activity-Dependent Influences on Auditory Circuits
    Daniel B Polley; Fiscal Year: 2013
    ..period regulation of binaural processing in the inferior colliculus, medial geniculate body and primary auditory cortex. Continuing studies will compare the effects of unilateral versus bilateral CHL on the functional ..
  32. Auditory Cortical Processing of Communication Sounds
    KAMAL K SEN; Fiscal Year: 2010
    b>Auditory cortex plays an important role in the processing of complex sounds e.g., vocal communication sounds and human speech...
  33. Songbird Neurogenomics Initiative
    David F Clayton; Fiscal Year: 2010
    ..how they compare to other regions including brain areas that correspond to parts of human brain (such as auditory cortex and cortical regions for the control of speech production)...
  34. Effects of language experience on early cortical and subcortical pitch encoding
    Ananthanarayan Krishnan; Fiscal Year: 2013
    ..approach to evaluate pitch representations at the brainstem (frequency following response, FFR) and auditory cortex (cortical pitch response, CPR) concurrently...
  35. Neural mechanisms of speech learning in older adults
    PATRICK C WONG; Fiscal Year: 2012
    ..in the decline-compensation model of the aging brain, which postulates that decline in sensory abilities (auditory cortex) can be compensated by increased engagement of general cognitive cortical regions such as the prefrontal ..
  36. Gene Expression During Postnatal Development of the Central Auditory Pathway
    Troy A Hackett; Fiscal Year: 2013
    ..in situ hybridization, and immunohistochemistry to: (1) identify genes that are differentially expressed in auditory cortex, medial geniculate, and inferior colliculus during postnatal development;and (2) localize the transcripts of ..
  37. Critical Periods of Recovery from Hearing Loss in the Developing Auditory Cortex
    Todd Mowery; Fiscal Year: 2013
    ..e., earplug removal) during development will influence cellular properties in auditory cortex. Both the onset of earplug insertion and the time of earplug removal will be varied as a function of ..
  38. Synaptic mechanisms of auditory memory
    Stanislav S Zakharenko; Fiscal Year: 2013
    ..The auditory cortex (ACx) acquires and retains specific memory traces about the behavioral significance of selected sounds...
  39. Voltage-sensitive dye imaging setup
    Dieter Jaeger; Fiscal Year: 2013
    ..allow this work to progress towards a better understanding of spatial and temporal signal flow beyond primary auditory cortex. For both Dr Jaeger and Dr...
  40. Cross-modal changes in auditory cortex circuitry after visual deprivation
    EMILY ROSE PETRUS; Fiscal Year: 2013
    ..Results from this work will directly impact our understanding of how spared sensory modalities become enhanced following the loss of one sense. ..
  41. Multisensory integration of faces and voices in the primate temporal lobe
    ASIF GHAZANFAR; Fiscal Year: 2013
    ..The focus of our work will be on what role the auditory cortex plays in integrating faces and voices, and how its role may different from that of the more traditional ..
  42. CRCNS: Optimality principles of auditory representations
    Kechen Zhang; Fiscal Year: 2013
    ..we also obtain a plausible network explanation of how complex response properties in inferior colliculus and auditory cortex might arise from combining multiple sound localization cues at lower levels in the auditory pathway...
  43. Cortical correlates of age-related hearing deficits
    GREGG HOWARD RECANZONE; Fiscal Year: 2013
    ..is due in large part to the lack of an effective animal model that (1) shares many organizational features of auditory cortex with humans, (2) has a reasonably long life span such that age-related hearing deficits progress over the ..
  44. Neural Encoding and Connectivity in human speech perception
    BRIAN PASLEY; Fiscal Year: 2013
    ..K99 phase, the first specific aim will investigate the neural representation of speech in higher order auditory cortex using a neural encoding model approach...
  45. The role of cortico-hippocampal interactions in encoding auditory memories
    DANIEL A BENDOR; Fiscal Year: 2012
    ..hippocampus for recall;however, this memory eventually becomes hippocampus-independent and consolidated in auditory cortex. Interactions between the hippocampus and cortex during sleep are thought to be critical for this process of ..
  46. Neurophysiology and Anatomy of Multisensory Processing
    Charles E Schroeder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multisensory Integration begins at or before the level of primary auditory cortex (A1) and builds over higher stages...
  47. FUNCTIONS OF NICOTINE RECEPTORS IN SENSORY NEOCORTEX
    Raju Metherate; Fiscal Year: 2012
    ..a potential cellular link: functional impairment of nicotinic acetylcholine receptors (nAChRs) in primary auditory cortex (A1)...
  48. The Neural Correlates and Mechanisms of Spatial Stream Segregation in Rat Primary
    JUSTIN DANIEL YAO; Fiscal Year: 2013
    ..stream segregation, we propose three specific aims: 1) Evaluate the spatial sensitivity of rat primary auditory cortex (A1);2) Characterize spatial stream segregation in rat A1;3) Determine the neural mechanisms of spatial ..
  49. Neuronal oscillations as a tool for attentional stream selection
    Elana Zion Golumbic; Fiscal Year: 2013
    ..these ideas, I will record electroencephalographic (EEG) signals from implanted electrodes in and surrounding auditory cortex in surgical epilepsy patients, while they engage in a series of auditory stream selection tasks...
  50. Impact of early auditory training on developemental hearing loss
    EMMA CHRISTINE SARRO; Fiscal Year: 2010
    ..How neural coding properties in auditory cortex (ACx) respond to early sensory experience will then be correlated to behavioral performance...
  51. Functional Neuroimaging and Transcranial Magnetic Stimulation in Mal de Debarquem
    YOON HEE K CHA; Fiscal Year: 2012
    ..Studies on tinnitus show that there is an area of heightened baseline activity in the auditory cortex and that this activity can be dampened with rTMS...
  52. Phonetic influences on auditory feedback control
    Caroline Niziolek; Fiscal Year: 2013
    ..On the other hand, a speaker may monitor his output at a sub-categorical level, before high-level auditory cortex imposes phonetic structure on the acoustic signal...
  53. CORTICAL REPRESENTATION OF AUDITORY SPACE
    John C Middlebrooks; Fiscal Year: 2012
    ..It will test the hypothesis that informational masking arises at the level of auditory cortex and that spatial masking release is enhanced in auditory cortical belt areas...
  54. Targeted Neural Plasticity for the Treatment of Tinnitus
    Richard S Tyler; Fiscal Year: 2013
    ..The tinnitus field generally accepts that elevated synchronous spontaneous activity in the auditory cortex may account for the tinnitus percept that arises following hearing loss...
  55. Animal Model of Speech Sound Processing in Autism
    Michael P Kilgard; Fiscal Year: 2013
    ..that in utero VPA exposure severely degrades the precise spatiotemporal patterns evoked by speech sounds in auditory cortex. As in autism, the longer latency in our animal model is significantly greater for speech sounds compared to ..
  56. Neurophysiology of somatosensory influences on auditory cortical processing
    Gabriella Musacchia; Fiscal Year: 2010
    ..questions by characterizing how vibrotactile inputs impact on the discriminative processing of sounds in auditory cortex. I will record neuronal activity from depth electrodes placed in primary and non-primary auditory cortices of ..
  57. Effects of Spectral Context on Responses in Auditory Cortex
    DENNIS BARBOUR; Fiscal Year: 2009
    ..and communication sound encoding in the mammalian auditory system by evaluating how neurons in primate auditory cortex integrate sound energy over a wide range of frequencies...
  58. The role of dendrite-targeting interneurons in auditory cortex
    BRYAN SEYBOLD; Fiscal Year: 2013
    ....
  59. Neural Correlates of Auditory Continuity
    POPPY A CRUM; Fiscal Year: 2010
    ..This proposal aims to study the neural correlates of auditory continuity in single neurons in the auditory cortex of the awake behaving common marmoset (Callithrix Jacchus) to understand how patterns of neural response ..
  60. Organization and experience-dependence of auditory coding in forebrain
    ALLISON JANE DOUPE; Fiscal Year: 2013
    ..hierarchical network of auditory areas that sub serve these tasks, including the avian equivalent of primary auditory cortex, field L, and several secondary areas that are the likely equivalent of belt cortex...
  61. FUNCTIONS OF NICOTINE RECEPTORS IN SENSORY NEOCORTEX
    Raju Metherate; Fiscal Year: 2013
    ..We hypothesize that activation of nAChRs will narrow RF tuning in primary auditory cortex (A1) and enhance processing within narrowed RFs, and that these cellular actions of nAChRs contribute to ..
  62. The Neural Basis of Perceptually-Relevant Auditory Modulations in Humans
    Jonathan Z Simon; Fiscal Year: 2012
    ..neuroscience is to understand how speech and other natural sounds are analyzed and encoded in the human auditory cortex. One major finding is that perception and speech processing are crucially affected by temporal modulations in ..
  63. Role of serotonin in auditory cortex regulation following early-onset sensorineur
    GREGORY BASURA; Fiscal Year: 2009
    ..Hearing impairments during early postnatal development produce significant changes in the human auditory cortex that may permanently diminish auditory perceptual skills and compromise language acquisition (Psarommatis et ..
  64. HUMAN AUDITORY CORTEX PHYSIOLOGY
    Matthew Howard; Fiscal Year: 2000
    The unifying focus of the proposed research is the study of human auditory cortex. The two specific areas of investigation will be: l) Cellular electrophysiology of human auditory cortex, 2) Feasibility studies of an auditory cortex ..
  65. Cortical Sensitivity to Acoustic Cues for Sound Location
    EWAN MACPHERSON; Fiscal Year: 2006
    ..Sound localization is a fundamental task of the auditory system, and in higher mammals, requires an intact auditory cortex. Many cortical neurons respond over broad regions of space and vary the rate and temporal pattern of their ..
  66. Feature selectivity of auditory thalamus
    Edward Bartlett; Fiscal Year: 2005
    ..arise from the MGB representations, given the comparatively large body of knowledge regarding responses of auditory cortex neurons to auditory stimuli...
  67. Technological Development Towards a Cortical Prosthesis
    Patrick Rousche; Fiscal Year: 2005
    ..Preliminary evidence suggests that direct electrical stimulation of the human auditory cortex can induce auditory perceptions...
  68. Cortical Electrical Suppression of Noise-Induced Tinnitus
    Jinsheng Zhang; Fiscal Year: 2010
    ..Among numerous management strategies being sought, auditory cortex electrical stimulation (ACES) has recently been used clinically to suppress tinnitus...
  69. ACTIVITY OF AI NEURONS IN LOCALIZING SOUNDS
    Gregg Recanzone; Fiscal Year: 2000
    ..An apparent paradox exists, where lesions of the auditory cortex result in profound sound localization deficits, but the spatial selectivity of most cells in auditory cortex ..
  70. Functional organization of auditory corticothalamic projection systems
    Daniel Llano; Fiscal Year: 2007
    ..Summary: The objective of the proposed studies is to understand the functional relationships between the auditory cortex and thalamus, and ultimately to uncover the neural substrates for auditory cognition...
  71. PARALLEL AUDITORY PATHWAYS IN THE BRAIN STEM
    Ellen Covey; Fiscal Year: 2006
    ..multiple auditory centers in the lower brainstem, from non-ascending auditory inputs from the opposite IC and auditory cortex and from motor-related structures...
  72. STRUCTURE OF PRIMARY AUDITORY CORTEX
    JEFFERY WINER; Fiscal Year: 1993
    This is a proposal to study the structure, connections, and neurochemical organization of the primary auditory cortex (AI), medial geniculate body, and inferior colliculus in several species...
  73. Optogenetic analysis of circuits for vocal recognition
    Richard Mooney; Fiscal Year: 2009
    ..Most of these conditions involve damage or dysfunction in the auditory cortex, indicating that this structure plays an essential role in vocal perception...
  74. CRCNS: Dynamics of the auditory cortical column
    Gyorgy Buzsaki; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The auditory cortex is a critical structure for processing of sound information in mammals...
  75. Single-unit response to AM sound in the auditory cortex.
    Mamiko Niwa; Fiscal Year: 2009
    ..We will record single-units responses in the primary auditory cortex (A1) and the middle-lateral field of the auditory cortex (ML) of non-human subjects while they actively ..
  76. CORTICAL REPRESENTATION OF AUDITORY SPACE
    JOHN MIDDLEBROOKS; Fiscal Year: 1991
    Clinical and animal studies indicate that lesions of the auditory cortex can result in deficits in the ability to localize a sound...
  77. Functional neuroanatomy of auditory object perception
    Amber Leaver; Fiscal Year: 2009
    ..in visual neuroscience, leaving significant gaps in our understanding of functional organization of human auditory cortex. The work proposed here will answer important questions regarding representation of auditory objects (i.e...
  78. Targeted Neural Plasticity for the Treatment of Tinnitus
    NAVZER ENGINEER; Fiscal Year: 2009
    ..Recent studies suggest that pathological reorganization of frequency mapping in the auditory cortex is a major contributor to the symptoms of tinnitus in many patients...