Genomes and Genes
Summary: Area of the occipital lobe concerned with vision.
Publications314 found, 100 shown here
- Population receptive field estimates in human visual cortexSerge O Dumoulin
Psychology, Stanford University, Stanford, CA 94305, USA
Neuroimage 39:647-60. 2008..We report quantitative estimates of pRF size in medial, lateral and ventral occipital regions of human visual cortex. Also, we quantify the amount of input from ipsi- and contralateral visual fields...
- Membrane potential synchrony in primary visual cortex during sensory stimulationJianing Yu
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
Neuron 68:1187-201. 2010When the primary visual cortex (V1) is activated by sensory stimulation, what is the temporal correlation between the synaptic inputs to nearby neurons? This question underlies the origin of correlated activity, the mechanism of how ..
- Differences in gamma frequencies across visual cortex restrict their possible use in computationSupratim Ray
Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 67:885-96. 2010..Instead, our results suggest that the gamma rhythm arises from local interactions between excitation and inhibition...
- Decoding reveals the contents of visual working memory in early visual areasStephenie A Harrison
Psychology Department and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37240, USA
Nature 458:632-5. 2009..Here we show that orientations held in working memory can be decoded from activity patterns in the human visual cortex, even when overall levels of activity are low...
- Local origin of field potentials in visual cortexSteffen Katzner
Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
Neuron 61:35-41. 2009..We determined the orientation selectivity of stimulus-evoked LFP signals in primary visual cortex and were able to predict it on the basis of the surrounding map of orientation preference...
- Neurophysiological investigation of the basis of the fMRI signalN K Logothetis
Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
Nature 412:150-7. 2001..activity with highly spatio-temporally resolved blood-oxygen-level-dependent (BOLD) fMRI responses from the visual cortex of monkeys...
- Network anatomy and in vivo physiology of visual cortical neuronsDavi D Bock
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 471:177-82. 2011..a functional property--the preferred stimulus orientation--of a group of neurons in the mouse primary visual cortex. Large-scale electron microscopy of serial thin sections was then used to trace a portion of these neurons' ..
- Highly nonrandom features of synaptic connectivity in local cortical circuitsSen Song
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
PLoS Biol 3:e68. 2005..with several hundred simultaneous quadruple whole-cell recordings from layer 5 pyramidal neurons in the rat visual cortex. Analysis of this dataset revealed several nonrandom features in synaptic connectivity...
- Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effectsR P Rao
Salk Institute, Sloan Center for Theoretical Neurobiology, La Jolla, California, USA
Nat Neurosci 2:79-87. 1999..results suggest that rather than being exclusively feedforward phenomena, nonclassical surround effects in the visual cortex may also result from cortico-cortical feedback as a consequence of the visual system using an efficient ..
- Synaptic activity and the construction of cortical circuitsL C Katz
Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Science 274:1133-8. 1996..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
- Alpha-band electroencephalographic activity over occipital cortex indexes visuospatial attention bias and predicts visual target detectionGregor Thut
Center for Noninvasive Brain Stimulation, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 26:9494-502. 2006..They suggest that the momentary direction of attention, predicting spatial biases in imminent visual processing, can be estimated from a lateralization index of posterior alpha-activity...
- Functional specificity of local synaptic connections in neocortical networksHo Ko
Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Nature 473:87-91. 2011..layer 2/3 pyramidal neurons in vitro, the response properties of which were first characterized in mouse visual cortex in vivo...
- Functional imaging with cellular resolution reveals precise micro-architecture in visual cortexKenichi Ohki
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 433:597-603. 2005..Here, we labelled thousands of neurons of the visual cortex with a calcium-sensitive indicator in vivo...
- Highly selective receptive fields in mouse visual cortexCristopher M Niell
Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143 0444, USA
J Neurosci 28:7520-36. 2008Genetic methods available in mice are likely to be powerful tools in dissecting cortical circuits. However, the visual cortex, in which sensory coding has been most thoroughly studied in other species, has essentially been neglected in ..
- Decorrelated neuronal firing in cortical microcircuitsAlexander S Ecker
Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
Science 327:584-7. 2010..multitetrode arrays offering unprecedented recording quality to reexamine this question in the primary visual cortex of awake macaques...
- Computational modelling of visual attentionL Itti
Hedco Neuroscience Building, University of Southern California, 3641 Watt Way, Los Angeles, California 90089 2520, USA
Nat Rev Neurosci 2:194-203. 2001..Insights from these five key areas provide a framework for a computational and neurobiological understanding of visual attention...
- Emergence of simple-cell receptive field properties by learning a sparse code for natural imagesB A Olshausen
Department of Psychology, Cornell University, Ithaca, New York 14853, USA
Nature 381:607-9. 1996The receptive fields of simple cells in mammalian primary visual cortex can be characterized as being spatially localized, oriented and bandpass (selective to structure at different spatial scales), comparable to the basis functions of ..
- Different origins of gamma rhythm and high-gamma activity in macaque visual cortexSupratim Ray
Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Biol 9:e1000610. 2011..We studied the relationship between high-gamma power, gamma rhythm, and spiking activity in the primary visual cortex (V1) of awake monkeys while varying the stimulus size, which increased the gamma power but decreased the ..
- Entrainment of neuronal oscillations as a mechanism of attentional selectionPeter Lakatos
Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
Science 320:110-3. 2008..Here, we show that when attended stimuli are in a rhythmic stream, delta-band oscillations in the primary visual cortex entrain to the rhythm of the stream, resulting in increased response gain for task-relevant events and ..
- Normalization as a canonical neural computationMatteo Carandini
UCL Institute of Ophtalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK ac uk
Nat Rev Neurosci 13:51-62. 2012..Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain ..
- A quantitative map of the circuit of cat primary visual cortexTom Binzegger
Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
J Neurosci 24:8441-53. 2004..The map of the whole cortical circuit shows that there are very few "strong" but many "weak" excitatory projections, each of which may involve only a few percentage of the total complement of excitatory synapses of a single neuron...
- Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuliBassam V Atallah
Computational Neurosciences Graduate Program, University of California San Diego, La Jolla, California 92093 0634, USA
Neuron 73:159-70. 2012..By bidirectionally manipulating PV cell activity in visual cortex we show that these neurons strongly modulate layer 2/3 pyramidal cell spiking responses to visual stimuli ..
- Division and subtraction by distinct cortical inhibitory networks in vivoNathan R Wilson
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 488:343-8. 2012..Here we use a new platform for two-way light-based circuit interrogation in visual cortex in vivo to show the computational implications of modulating different subclasses of inhibitory neurons during ..
- Dendritic organization of sensory input to cortical neurons in vivoHongbo Jia
Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
Nature 464:1307-12. 2010In sensory cortex regions, neurons are tuned to specific stimulus features. For example, in the visual cortex, many neurons fire predominantly in response to moving objects of a preferred orientation...
- Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cellsBao Hua Liu
Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA
Neuron 71:542-54. 2011Orientation selectivity (OS) is an emergent property in the primary visual cortex (V1). How OS arises from synaptic circuits remains unsolved...
- Activity-dependent scaling of quantal amplitude in neocortical neuronsG G Turrigiano
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
Nature 391:892-6. 1998....
- miR-132, an experience-dependent microRNA, is essential for visual cortex plasticityNikolaos Mellios
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Nat Neurosci 14:1240-2. 2011Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation...
- Dynamic predictions: oscillations and synchrony in top-down processingA K Engel
Cellular Neurobiology Group, Institute for Medicine, Research Centre Julich, 52425 Julich, Germany
Nat Rev Neurosci 2:704-16. 2001....
- High-frequency, long-range coupling between prefrontal and visual cortex during attentionGeorgia G Gregoriou
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 324:1207-10. 2009..Does this synchrony result from intrinsic activity in visual cortex or from inputs from other structures? Using paired recordings in the frontal eye field (FEF) and area V4, we ..
- Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticityAlexey Harauzov
Scuola Normale Superiore, 56126 Pisa, Italy
J Neurosci 30:361-71. 2010..is suggested to be crucial for the closure of the critical period for ocular dominance (OD) plasticity in the visual cortex. We find that reduction of GABAergic transmission in the adult rat visual cortex partially reactivates OD ..
- The antidepressant fluoxetine restores plasticity in the adult visual cortexJosé Fernando Maya Vetencourt
Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
Science 320:385-8. 2008..by reduced intracortical inhibition and increased expression of brain-derived neurotrophic factor in the visual cortex. Cortical administration of diazepam prevented the effects induced by fluoxetine, indicating that the ..
- Attention improves performance primarily by reducing interneuronal correlationsMarlene R Cohen
Howard Hughes Medical Institute and Harvard Medical School Department of Neurobiology, Boston, Massachusetts, USA
Nat Neurosci 12:1594-600. 2009..These results suggest that the representation of sensory information in populations of neurons and the way attention affects the sensitivity of the population may only be understood by considering the interactions between neurons...
- A neural circuit for spatial summation in visual cortexHillel Adesnik
Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, California 92093 0634, USA
Nature 490:226-31. 2012The response of cortical neurons to a sensory stimulus is modulated by the context. In the visual cortex, for example, stimulation of a pyramidal cell's receptive-field surround can attenuate the cell's response to a stimulus in the ..
- View from the top: hierarchies and reverse hierarchies in the visual systemShaul Hochstein
Department of Neurobiology, Neural Computation Center, Hebrew University, Jerusalem, Israel
Neuron 36:791-804. 2002..Search for conjunctions or fine discriminations depends on reentry to low-level specific receptive fields using serial focused attention, consistent with recently reported primary visual cortex effects.
- The normalization model of attentionJohn H Reynolds
Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
Neuron 61:168-85. 2009Attention has been found to have a wide variety of effects on the responses of neurons in visual cortex. We describe a model of attention that exhibits each of these different forms of attentional modulation, depending on the stimulus ..
- Sparse coding of sensory inputsBruno A Olshausen
Center for Neuroscience, UC Davis, 1544 Newton Court, Davis, California 95616, USA
Curr Opin Neurobiol 14:481-7. 2004..Recent physiological recordings from sensory neurons have indicated that sparse coding could be a ubiquitous strategy employed in several different modalities across different organisms...
- Natural image statistics and neural representationE P Simoncelli
Howard Hughes Medical Institute, Center for Neural Science, and Courant Institute of Mathematical Sciences, New York University, New York, NY 10003 USA
Annu Rev Neurosci 24:1193-216. 2001....
- Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortexSonja B Hofer
Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
Nat Neurosci 14:1045-52. 2011..and network activity in pyramidal cells and fast-spiking parvalbumin-expressing (PV) interneurons in mouse visual cortex. In pyramidal cell populations, patterns of neuronal correlations were largely stimulus-dependent, indicating ..
- Decoding the visual and subjective contents of the human brainYukiyasu Kamitani
ATR Computational Neuroscience Laboratories, 2 2 2 Hikaridai, Keihanna Science City, Kyoto 619 0288, Japan
Nat Neurosci 8:679-85. 2005..These results demonstrate that fMRI activity patterns in early visual areas, including primary visual cortex (V1), contain detailed orientation information that can reliably predict subjective perception...
- Increased activity in human visual cortex during directed attention in the absence of visual stimulationS Kastner
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Neuron 22:751-61. 1999When subjects direct attention to a particular location in a visual scene, responses in the visual cortex to stimuli presented at that location are enhanced, and the suppressive influences of nearby distractors are reduced...
- Very slow activity fluctuations in monkey visual cortex: implications for functional brain imagingDavid A Leopold
Max Planck Institut für biologische Kybernetik, Spemannstrasse 38, 72076 Tubingen, Germany
Cereb Cortex 13:422-33. 2003..in band-limited power (BLP) of local field potential (LFP) signals recorded from multiple electrodes in visual cortex of the monkey during different behavioral states...
- Reactivation of ocular dominance plasticity in the adult visual cortexTommaso Pizzorusso
Scuola Normale Superiore, 56100 Pisa, Italy
Science 298:1248-51. 2002..whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was ..
- The phase of ongoing EEG oscillations predicts visual perceptionNiko A Busch
Universite de Toulouse, Centre de Recherche Cerveau et Cognition, Universite Paul Sabatier, France
J Neurosci 29:7869-76. 2009..The results support the notion that ongoing oscillations shape our perception, possibly by providing a temporal reference frame for neural codes that rely on precise spike timing...
- Visual field maps in human cortexBrian A Wandell
Psychology Department, Stanford University, Stanford, CA 94305 2130, USA
Neuron 56:366-83. 2007Much of the visual cortex is organized into visual field maps: nearby neurons have receptive fields at nearby locations in the image...
- Ventral visual cortex in humans: cytoarchitectonic mapping of two extrastriate areasClaudia Rottschy
Institute of Medicine, Research Centre Julich, Germany
Hum Brain Mapp 28:1045-59. 2007The extrastriate visual cortex forms a complex system enabling the analysis of visually presented objects...
- The emergence of functional microcircuits in visual cortexHo Ko
Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
Nature 496:96-100. 2013..synaptic connectivity to visual response properties of neighbouring layer 2/3 pyramidal neurons in mouse visual cortex at different postnatal ages, using two-photon calcium imaging in vivo and multiple whole-cell recordings in ..
- Integrated model of visual processingJ Bullier
Centre de Recherche Cerveau et Cognition CNRS UPS, Universite Paul Sabatier, 133 route de Narbonne, 31062, Cedex 4, Toulouse, France
Brain Res Brain Res Rev 36:96-107. 2001....
- Lynx1, a cholinergic brake, limits plasticity in adult visual cortexHirofumi Morishita
FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Science 330:1238-40. 2010..we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life. Removal of this molecular brake enhanced nicotinic acetylcholine receptor signaling...
- Spatial and temporal scales of neuronal correlation in primary visual cortexMatthew A Smith
Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 28:12591-603. 2008..These properties and the circuit mechanism they imply provide new constraints on the functional role that correlation may play in visual processing...
- Matching categorical object representations in inferior temporal cortex of man and monkeyNikolaus Kriegeskorte
Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD 20892 1148, USA
Neuron 60:1126-41. 2008..Our findings suggest that primate IT across species may host a common code, which combines a categorical and a continuous representation of objects...
- Local GABA circuit control of experience-dependent plasticity in developing visual cortexT K Hensch
Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Science 282:1504-8. 1998..An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model...
- Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern visionJennifer L Ecker
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 67:49-60. 2010..Thus, nonclassical retinal photoreception occurs within diverse cell types and influences circuits and functions encompassing luminance as well as spatial information...
- GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppressionJong H Yoon
Department of Psychiatry and Imaging Research Center, University of California, Davis, Davis, California 95817, USA
J Neurosci 30:3777-81. 2010..10). These results suggest that a neocortical GABA deficit in subjects with schizophrenia leads to impaired cortical inhibition and that GABAergic synaptic transmission in visual cortex plays a critical role in OSSS.
- Spatial attention decorrelates intrinsic activity fluctuations in macaque area V4Jude F Mitchell
Systems Neurobiology Lab, The Salk Institute, La Jolla, CA 92037 1099, USA
Neuron 63:879-88. 2009..This attention-dependent reduction of ongoing cortical activity improves the signal-to-noise ratio of pooled neural signals substantially more than attention-dependent increases in firing rate...
- Structure and function of visual area MTRichard T Born
Department of Neurobiology, Harvard Medical School, Boston, MA 02115 5701, USA
Annu Rev Neurosci 28:157-89. 2005..Here we attempt a synthetic overview of the rich literature on MT with the goal of answering the question, What does MT do?..
- Modulation of visual responses by behavioral state in mouse visual cortexCristopher M Niell
W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0444, USA
Neuron 65:472-9. 2010..We have now studied the response properties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating spherical treadmill with their heads fixed...
- Synaptic and network mechanisms of sparse and reliable visual cortical activity during nonclassical receptive field stimulationBilal Haider
Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Neuron 65:107-21. 2010..spiking and membrane potential responses in classical regular spiking (RS(C)) pyramidal neurons of cat primary visual cortex. Conversely, fast-spiking interneurons exhibit increased activity and decreased selectivity during CRF + nCRF ..
- Basal forebrain activation enhances cortical coding of natural scenesMichael Goard
Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA
Nat Neurosci 12:1444-9. 2009..Using polytrode recording in rat visual cortex, we found that nucleus basalis stimulation caused prominent decorrelation between neurons and marked ..
- Electrophysiological correlates of rapid spatial orienting towards fearful facesGilles Pourtois
Neurology and Imaging of Cognition, University of Geneva, Switzerland
Cereb Cortex 14:619-33. 2004..These data suggest that activity in primary visual cortex might be enhanced by fear cues as early as 90 ms post-stimulus, and that such effects might result in a ..
- Mechanisms of visual attention in the human cortexS Kastner
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Neurosci 23:315-41. 2000..The competition among multiple objects in visual cortex can be biased by both bottom-up sensory-driven mechanisms and top-down influences, such as selective attention...
- Modulation of oscillatory neuronal synchronization by selective visual attentionP Fries
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
Science 291:1560-3. 2001..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
- BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortexZ J Huang
Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 98:739-55. 1999Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear...
- A cortical area selective for visual processing of the human bodyP E Downing
School of Psychology, Centre for Cognitive Neuroscience, University of Wales, Bangor LL57 2AS, UK
Science 293:2470-3. 2001Despite extensive evidence for regions of human visual cortex that respond selectively to faces, few studies have considered the cortical representation of the appearance of the rest of the human body...
- Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortexAaron M Kerlin
Department of Neurobiology, Harvard Medical School, Goldenson 243, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 67:858-71. 2010..neurons (immunoreactive for parvalbumin, somatostatin, or vasoactive intestinal peptide) in layer 2/3 of mouse visual cortex. Excitatory neurons had sharp response selectivity for stimulus orientation and spatial frequency, while all ..
- Do we know what the early visual system does?Matteo Carandini
Smith Kettlewell Eye Research Institute, San Francisco, California 94115, USA
J Neurosci 25:10577-97. 2005..They would be an invaluable guide for understanding the underlying biophysical and anatomical mechanisms and relating neural responses to visual perception...
- Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortexTara Keck
Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
Neuron 71:869-82. 2011..Here, we use two-photon imaging to monitor the fine structure of inhibitory neurons in mouse visual cortex after deprivation induced by retinal lesions...
- Cortical sources of the early components of the visual evoked potentialFrancesco Di Russo
Department of Neurosciences, UCSD, La Jolla, California 92093 0608, USA
Hum Brain Mapp 15:95-111. 2002..These findings clarify the anatomical origin of these VEP components, which have been studied extensively in relation to visual-perceptual processes...
- Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical periodBidisha Chattopadhyaya
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Neurosci 24:9598-611. 2004..In the primary visual cortex, for example, it is unknown whether, and to what extent, the formation and maturation of perisomatic synapses ..
- Gain modulation by nicotine in macaque v1Anita A Disney
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
Neuron 56:701-13. 2007..We demonstrate that at the site of thalamic input to visual cortex, the effect of this nAChR-mediated gain is an enhancement of the detection of visual stimuli.
- Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortexHesheng Liu
Department of Neuroscience and Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Neuron 62:281-90. 2009..The timing of neurophysiological responses in visual cortex plays a key role in distinguishing between bottom-up and top-down theories...
- Gamma-band synchronization in visual cortex predicts speed of change detectionThilo Womelsdorf
FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
Nature 439:733-6. 2006....
- Synfire chains and cortical songs: temporal modules of cortical activityYuji Ikegaya
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Science 304:559-64. 2004..Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing...
- Excitatory cortical neurons form fine-scale functional networksYumiko Yoshimura
Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 433:868-73. 2005..We tested for fine-scale specificity of connections to cortical layer 2/3 pyramidal neurons in rat visual cortex by using cross-correlation analyses of synaptic currents evoked by photostimulation...
- Stimulus dependence of neuronal correlation in primary visual cortex of the macaqueAdam Kohn
Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 25:3661-73. 2005..We investigated the source of correlated responsivity by recording from pairs of single neurons in primary visual cortex of anesthetized macaque monkeys and comparing correlated variability and synchrony for spontaneous activity ..
- Robust object recognition with cortex-like mechanismsThomas Serre
Massachusetts Institute of Technology, Center for Biological and Computational Learning, McGovern Institute for Brain Research and Brain and Cognitive Sciences Department, MA 02139, USA
IEEE Trans Pattern Anal Mach Intell 29:411-26. 2007..which is motivated by biology: We describe a hierarchical system that closely follows the organization of visual cortex and builds an increasingly complex and invariant feature representation by alternating between a template ..
- Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humansSuresh D Muthukumaraswamy
Cardiff University Brain Research Imaging Centre, School of Psychology and CUBRIC and Schools of Chemistry and Biosciences, Cardiff University, Cardiff, United Kingdom
Proc Natl Acad Sci U S A 106:8356-61. 2009..cortical inhibition by combining magnetic resonance spectroscopy to quantify resting GABA concentration in the visual cortex, MEG to measure stimulus-induced visual gamma oscillations and fMRI to measure the BOLD response to a simple ..
- Development and plasticity of the primary visual cortexJ Sebastian Espinosa
Center for Integrative Neuroscience, Department of Physiology, 675 Nelson Rising Lane, University of California, San Francisco, San Francisco, CA 94143 0444, USA
Neuron 75:230-49. 2012Hubel and Wiesel began the modern study of development and plasticity of primary visual cortex (V1), discovering response properties of cortical neurons that distinguished them from their inputs and that were arranged in a functional ..
- Human EEG responses to 1-100 Hz flicker: resonance phenomena in visual cortex and their potential correlation to cognitive phenomenaC S Herrmann
Max-Planck Institute of Cognitive Neuroscience, Postfach 500 355, 04303 Leipzig, Germany
Exp Brain Res 137:346-53. 2001The individual properties of visual objects, like form or color, are represented in different areas in our visual cortex. In order to perceive one coherent object, its features have to be bound together...
- Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortexJames Schummers
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 320:1638-43. 2008..We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive ..
- The retinotopic organization of the human middle temporal area MT/V5 and its cortical neighborsHauke Kolster
Laboratorium voor Neurofysiologie en Psychofysiologie, Katholieke Universiteit Leuven Medical School, Campus Gasthuisberg, 3000 Leuven, Belgium
J Neurosci 30:9801-20. 2010..Together with similarities in retinotopic organization and topological neighborhood, the functional properties suggest that MT/V5 in human and macaque cortex are homologous...
- GABAA inhibition controls response gain in visual cortexSteffen Katzner
UCL Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
J Neurosci 31:5931-41. 2011..To test these proposals, we recorded in cat primary visual cortex (V1) after local iontophoresis of gabazine, the selective GABA(A) antagonist...
- Reward timing in the primary visual cortexMarshall G Shuler
Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 311:1606-9. 2006..visual stimuli and subsequent rewards, the responses of a substantial fraction of neurons in the primary visual cortex evolve from those that relate solely to the physical attributes of the stimuli to those that accurately ..
- Spontaneously emerging cortical representations of visual attributesTal Kenet
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
Nature 425:954-6. 2003..Using voltage sensitive dye imaging, we previously established a close link between ongoing activity in the visual cortex of anaesthetized cats and the spontaneous firing of a single neuron...
- Functional magnetic resonance imaging (fMRI) "brain reading": detecting and classifying distributed patterns of fMRI activity in human visual cortexDavid D Cox
Rowland Institute for Science, Cambridge, MA 02142, USA
Neuroimage 19:261-70. 2003....
- The frequency of visually induced γ-band oscillations depends on the size of early human visual cortexD Samuel Schwarzkopf
Wellcome Trust Centre for Neuroimaging, University College London UCL Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 32:1507-12. 2012..We propose that individual differences in macroscopic gamma frequency may be attributed to interindividual variability in the microscopic architecture of visual cortex.
- Local diversity and fine-scale organization of receptive fields in mouse visual cortexVincent Bonin
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 31:18506-21. 2011..For example, are neurons in mouse visual cortex--whose preferred orientations are arranged randomly--organized with respect to other response properties? ..
- Topographic organization of projections from the amygdala to the visual cortex in the macaque monkeyD G Amaral
Department of Psychiatry, Center for Neuroscience, 1544 Newton Court, Davis, CA 95616, USA
Neuroscience 118:1099-120. 2003..cells, in the intermediate and parvicellular regions, project to more rostral and medial portions of the visual cortex. These results suggest that the amygdala may have substantial modulatory control over sensory processing at ..
- Attention reduces stimulus-driven gamma frequency oscillations and spike field coherence in V1Matthew Chalk
School of Informatics, University of Edinburgh, Edinburgh, UK
Neuron 66:114-25. 2010..This decrease could reflect an attention-mediated reduction of surround inhibition. Changes in synchrony in V1 would thus be a byproduct of reduced inhibitory drive, rather than a mechanism that directly aids perceptual processing...
- Sound-driven synaptic inhibition in primary visual cortexGiuliano Iurilli
Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
Neuron 73:814-28. 2012..cortex by a noise burst drove local GABAergic inhibition on supragranular pyramids of the mouse primary visual cortex, via cortico-cortical connections...
- Development of direction selectivity in mouse cortical neuronsNathalie L Rochefort
Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
Neuron 71:425-32. 2011Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience...
- Circuits for local and global signal integration in primary visual cortexAlessandra Angelucci
Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA
J Neurosci 22:8633-46. 2002Contrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond ..
- A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortexMing Gao
Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742, USA
J Neurosci 30:7168-78. 2010Visual experience scales down excitatory synapses in the superficial layers of visual cortex in a process that provides an in vivo paradigm of homeostatic synaptic scaling...
- Sounds reset rhythms of visual cortex and corresponding human visual perceptionVincenzo Romei
Institute of Neuroscience and Psychology, University of Glasgow, 58 Hillhead Street, Glasgow G12 8QB, UK
Curr Biol 22:807-13. 2012..We presented brief sounds and concurrently recorded electroencephalography (EEG) and/or probed visual cortex excitability (phosphene perception) through occipital transcranial magnetic stimulation (TMS)...
- Linking retinotopic fMRI mapping and anatomical probability maps of human occipital areas V1 and V2A M Wohlschlager
Institut fur Medizin, Forschungszentrum Julich, Germany
Neuroimage 26:73-82. 2005....
- Mechanisms underlying development of visual maps and receptive fieldsAndrew D Huberman
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Annu Rev Neurosci 31:479-509. 2008..the mechanisms by which spontaneous activity in the developing retina, lateral geniculate nucleus, and visual cortex instruct the axonal and dendritic refinements that give rise to orderly connections in the visual system...
- Spatial and temporal receptive fields of geniculate and cortical cells and directional selectivityR L De Valois
Department of Psychology, University of California, 3210 Tolman Hall 1650, 94720 1650, Berkeley, CA, USA
Vision Res 40:3685-702. 2000....
- Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at restAmir Shmuel
Montreal Neurological Institute, Departments of Neurology and Neurosurgery and Biomedical Engineering, McGill University, Montreal, QC, Canada
Hum Brain Mapp 29:751-61. 2008..BOLD fluctuations in widespread areas in visual cortex of both hemispheres were significantly correlated with neuronal activity from a single recording site in V1...
- When is early visual cortex activated during visual mental imagery?Stephen M Kosslyn
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Psychol Bull 129:723-46. 2003Although many neuroimaging studies of visual mental imagery have revealed activation in early visual cortex (Areas 17 or 18), many others have not...
- Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticitySayaka Sugiyama
Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Cell 134:508-20. 2008Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity...
- Language-specific tuning of visual cortex? Functional properties of the Visual Word Form AreaLaurent Cohen
Institut de Neurologie, Hopital de la Salpetriere, AP HP, Paris, France
Brain 125:1054-69. 2002..Moreover, activations in the precuneus and the left thalamus were observed when subjects were reading RVF versus left visual field (LVF) words, and are likely to reflect the attentional component of the RVF advantage...
- Inhibition, spike threshold, and stimulus selectivity in primary visual cortexNicholas J Priebe
Section of Neurobiology, University of Texas at Austin, 1 University Station C0920, Austin, TX 78712, USA
Neuron 57:482-97. 2008Ever since Hubel and Wiesel described orientation selectivity in the visual cortex, the question of how precise selectivity emerges has been marked by considerable debate. There are essentially two views of how selectivity arises...
- Structural correlates of rapid cortical plasticityMriganka Sur; Fiscal Year: 2010..Primary visual cortex (V1) has been a proving ground for describing the phenomena and mechanisms of activity- dependent plasticity ..
- DYNAMIC PROPERTIES OF ADULT VISUAL CORTEX--ROLE OF NOMichael Friedlander; Fiscal Year: 2003..The adult visual cortex was thought to be less susceptible to peripheral effects and less able to functionally reorganize in an ..
- GABAergic Circuits Critical period in Visual CortexZ Huang; Fiscal Year: 2005..The cellular and molecular mechanisms underlying the critical period plasticity in visual cortex will provide insight into the development of other sensory and cognitive functions, learning and memory, ..
- DEVELOPMENT AND PLASTICITY OF THE VISUAL SYSTEMMICHAEL STRYKER; Fiscal Year: 2004..the mechanisms by which patterns of neural activity guide the development and plasticity of the mammalian visual cortex. Our previous research has shown that spontaneous neural activity in the visual system is required for the ..
- Neurotoxicity of Methylmercury in the Visual CortexYukun Yuan; Fiscal Year: 2007..Corresponding to the visual deficits are region-selective pathological lesions in the visual cortex. The underlying mechanisms for these impairments remain poorly understood, although it appears that the MeHg-..
- Vision Sciences Training GrantCarol A Mason; Fiscal Year: 2013..Biomedical Engineering and Neuroscience, with 6 investigators in the Mahoney Center studying the primate visual cortex;they use an fMRI facility in the Neurological Institute, and participate in the Center for Theoretical ..
- Modulation of subcortical visual information processingCHARLES LEROY COX; Fiscal Year: 2012..nucleus (dLGN) serves as the primary thalamic relay for the transfer of retinal information to primary visual cortex. In addition to sensory signaling, thalamocortical circuits are involved in alterations of behavioral states (..
- Mechanisms and Therapeutics for Rett SyndromeMriganka Sur; Fiscal Year: 2013..maturation and circuit plasticity through intracellular electrophysiology in vitro and optical imaging of visual cortex in vivo during experience-dependent plasticity...
- DETERMINATION OF NEURONAL FATES IN VISUAL CORTEXSusan K McConnell; Fiscal Year: 2013..of this research is to understand the cellular and molecular processes by which young neurons in the mammalian visual cortex achieve their adult identities during development, migrate to appropriate positions, and form axonal ..
- Structural determinants of DTI observations in developing cortex and white matterChristopher D Kroenke; Fiscal Year: 2013..enucleation because this manipulation is known to induce abnormal patterns of neural connections in the visual cortex of altricial species such as rodents and ferrets...
- Modulation of subcortical visual information processingCharles Cox; Fiscal Year: 2009..nucleus (dLGN) serves as the primary thalamic relay for the transfer of retinal information to primary visual cortex. In addition to sensory signaling, thalamocortical circuits are involved in alterations of behavioral states (..
- Alcohol and Development of the Prefrontal CortexLEON GARLAND COLEMAN; Fiscal Year: 2011..of unique high environment regulated plasticity occurs for many brain regions with the most studied being visual cortex. During these "critical periods of plasticity", developmental processes result in the formation of persisting ..
- Neurochemical and metabolic regulation in the visual cortexMARGARET TT WONG-RILEY; Fiscal Year: 2013..They will also provide the basis for future gene therapy for visual deficits resulting from faulty energy metabolism. ..
- Control of Excitatory Synapse Formation and Maturation by AstrocytesWILLIAM CHRISTOPHER RISHER; Fiscal Year: 2013..imaging, serial section EM and electrophysiology in both purified cortical neurons and slice preparations from visual cortex, the proposed work should provide new molecular insight into the role of astrocytes in excitatory ..
- Cross-modal re-organization in children with cochlear implantsJulia Dee Campbell; Fiscal Year: 2013..By presenting visual stimuli to implanted children, visual cortex becomes activated and may be observed as a response in the occipital lobe through topographic scalp maps of ..
- FETAL AND POSTNATAL DEVELOPMENT OF VISUAL CONNECTIONSCarla J Shatz; Fiscal Year: 2013..release the brake" on ocular dominance (OD) plasticity, a form of experience-dependent synaptic plasticity in visual cortex? In the immune system PirB is a receptor for Major Histocompatibility Class I molecules, famous ligands for T-..
- Cell type-based genomics of developmental plasticity in cortical GABA interneuronZ Josh Huang; Fiscal Year: 2010..For example, maturation of inhibitory circuitry in primary visual cortex (V1) promotes the development of ocular dominance (OD) plasticity and its critical period, but the cellular ..
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXChristoph E Schreiner; Fiscal Year: 2013..These properties bear some similarities to emergent processing features in simple and complex cells of primary visual cortex. The goal is to characterize these features and compare their properties across cortical fields and across ..
- EnerCage: A Scalable Array of Intelligent Wireless Sensor Modules to Energize andMaysam Ghovanloo; Fiscal Year: 2010..It has provided groundbreaking information on areas ranging from the organization of primary visual cortex to neural correlates of working memory, which has helped in the treatment of disorders ranging from ..
- DEVELOPMENTAL REGULATION OF GLUTAMATE RECEPTOR FUNCTIONMARTHA NA CONSTANTINE-PATON; Fiscal Year: 2012..In visual cortex cultures we will characterize the engineered receptors'binding characteristics and targeting...
- Development of Synaptic Plasticity in Visual CortexMichael J Friedlander; Fiscal Year: 2010..In particular, the neurons of the primary visual cortex can use such synaptic plasticity to perform parallel computations on aspects of visual processing...
- Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain FunctionWei Chen; Fiscal Year: 2013..to conduct functional studies using visual stimulation to examine if CMRATP increases in the activated visual cortex for supporting higher energy demand and stimulus-evoked neuronal activity;4) to conduct extracellular neuron-..
- REM mechanisms in neocortical developmentMarcos G Frank; Fiscal Year: 2013..by quantitatively measuring and manipulating vigilance states and binocular visual input to primary visual cortex in the freely-behaving animal...
- Role of glial glutamate transporters in V1 plasticity and developmentJeremy C Petravicz; Fiscal Year: 2013DESCRIPTION (provided by applicant): Neuronal networks in the visual cortex integrate synaptic inputs to make complex outputs that underlie vision...
- HDAC4-mediated Photoreceptor Protection in Retinal DegenerationBo Chen; Fiscal Year: 2013..restore visual function using: 1) electrophysiology to test the integrity of neural circuits in the retina and visual cortex;2) behavioral tests to determine whether rescued retinal function can guide complex behaviors...
- Sleep, proprioception, and forebrain activity in infant mutant miceMARK SAMUEL BLUMBERG; Fiscal Year: 2013..and between neocortex and hippocampus, just as retinal waves are thought to contribute to the development of visual cortex and related structures...
- Cell Type-Specific Synaptic Defects in Angelman Syndrome Model MiceMichael L Wallace; Fiscal Year: 2012..I will use an AS model mouse and take advantage of the well-characterized circuitry of the visual cortex to determine the synaptic basis for the seizures in AS patients...
- Inhibitory Interneurons in Tourette SyndromeFlora M Vaccarino; Fiscal Year: 2010..motor and premotor regions and the insula, areas that are overactive during tics, as compared to primary visual cortex, an area not activated by tic behavior...
- STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUSJonathan C Horton; Fiscal Year: 2012..advantage of pursuing experiments in nonhuman primates is that one can perform microelectrode studies in the visual cortex to probe the neural basis of visual suppression...
- Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortexKaren L Montey; Fiscal Year: 2012..Interestingly, application of GABA agonists directly to the aged visual cortex induces an immediate increase in stimulus selectivity, suggesting the decline in stimulus selectivity may be ..
- A 2-photon/confocal microscope for imaging of neural development and functionWesley J Thompson; Fiscal Year: 2010..These investigations include an NEI-funded study of normal binocular integration in visual cortex and its disruption by strabismus, an NIDCD-funded study of membrane conductances, synaptic placement, and ..
- Global synaptic plasticity mechanisms in visual cortexHey Kyoung Lee; Fiscal Year: 2013..provided by applicant): Visual experience can produce long-lasting changes in the function of the primary visual cortex (V1), especially during a critical period early in postnatal life...
- Cortical Structure and Function in Blindness and following Restored VisionGeoffrey Karl Aguirre; Fiscal Year: 2013..e., activation to an auditory stimulus), and have altered cortical structure (i.e., atrophy of the visual cortex white matter and disruption of white matter fiber coherence along the optic radiations), we also find enormous ..
- Combining cerebral lesions & monkey fMRI for studying cortical network functionSTELIOS MANOLIS SMIRNAKIS; Fiscal Year: 2010..Posterior circulation infarcts, hemorrhages or traumatic brain injury often injure the primary visual cortex (V1) resulting in partial or complete hemianopsias, which are considerably disruptive to vision- dependent ..
- PHOTOTRANSDUCTION ENZYMESKRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2013..This signal is eventually relayed to the visual cortex of the brain, where visual perception occurs...
- Binocular Approaches to Perceptual Learning in Adult AmblyopiaCRISTINA LLERENA LAW; Fiscal Year: 2013..If uncorrected, amblyopia results in the unaffected eye controlling the binocular visual cortex, while the ability f the affected eye to stimulate cortical neurons may weaken to the point of functional ..
- Development of Visual PathwaysHwai Jong Cheng; Fiscal Year: 2013..segregated into layers in the lateral geniculate nucleus, and into ocular dominance columns in primary visual cortex. During the past half century, the development of this segregation has served as a premier model for the ..
- Role of Arc in synaptic/experience-dependent plasticity in mouse visual cortexJASON DENNIS SHEPHERD; Fiscal Year: 2012..The visual cortex is an ideal preparation to probe these questions as visual experience can be modulated to induce gross changes ..
- Neural and Cognitive Correlates of Methamphetamine Use in SchizophreniaRUTH EILEEN SALO; Fiscal Year: 2012..Rostral;and 3) Caudal anterior cingulate cortex (rACC and cACC);as well as 4) a control region the primary visual cortex (PVC)...
- Understanding feature-based auditory-visual interactions.Satoru Suzuki; Fiscal Year: 2013..signals influence neural activation throughout the visual pathways including in the mid brain and primary visual cortex. It is therefore important to extend the rigorous theories of vision to integrate multimodal contexts...
- Floating Light Activated Micro-Electrical Stimulators for Neural ProstheticsMesut Sahin; Fiscal Year: 2012..of the cochlear nucleus, midbrain, or auditory cortex to restore hearing, and stimulation of the visual cortex in the blind subjects...
- Phase 1/2 Trial of rAAV2-CB-hRPE65 (BB-IND 13848, 11 Sep 2009) for Leber CongenitJeffrey D Chulay; Fiscal Year: 2013..by a nondetectable electroretinogram (ERG) but with relatively preserved photoreceptor structure and an intact visual cortex that is responsive to high intensity light stimulation...
- Role of Arc in synaptic/experience-dependent plasticity in mouse visual cortexJASON DENNIS SHEPHERD; Fiscal Year: 2013..The visual cortex is an ideal preparation to probe these questions as visual experience can be modulated to induce gross changes ..
- Molecular regulation of experience-dependent synapse and dendrite stabilizationJENNIFER HELEN LESLIE; Fiscal Year: 2010..activity-dependent stabilization of synapses and dendrites during neuronal circuit formation in the developing visual cortex of a cpg15 knockout mouse...
- An In Vivo/In Vitro 2-Photon Uncaging/Imaging MicroscopeMartha Constantine Paton; Fiscal Year: 2010..the development of brain ventricles, studies of the role of inhibitory interneurons and astrocytes in visual cortex dynamics, spine dynamics in mouse models of autism and schizophrenia, and the contribution of postsynaptic ..
- Interaction of Visual and Oculomotor Signals in CortexTirin Moore; Fiscal Year: 2013..saccades to pursue the relationship between saccade target selection and neural correlates of attention in visual cortex. Specifically, we will study the influence of saccade preparation on neural correlates of bottom-up and ..
- Alcohol in Neocortex Development and PlasticityALEXANDRE ESTEVES MEDINA; Fiscal Year: 2013..We showed that third trimester alcohol exposure lead to a persistent disruption in visual cortex organization and neuronal plasticity...
- Biological Spatial Resolution Limits in fMRIJONATHAN RIZZO POLIMENI; Fiscal Year: 2013..The long-term objective of this project is to enable non-invasive imaging of fine-scale details of the human visual cortex, including the distinctive spatial maps of orientation preference, ocular dominance, and retinotopy, with a ..
- CRCNS: Collaborative Research: Model-Based Control of Spreading DepressionSteven J Schiff; Fiscal Year: 2013..The project starts by developing an experimental preparation using a tangential 2-dimensional visual cortex rodent brain slice...
- Imaging PTEN-induced changes in adult cortical structure and function in vivoJoshua Trachtenberg; Fiscal Year: 2012..to guide the placement of in vivo whole cell patch recordings from growing neurons in the mouse primary visual cortex. We also use 2-photon imaging to image network activity in the cortex of knockout and wildtype mice...
- Regulation of Spine Morphogenesis by NrCAMPatricia F Maness; Fiscal Year: 2013..responses will be measured in star pyramidal neurons, the principal target of thalamocortical input to visual cortex (layer 4), in visual cortical slices of WT and NrCAM null mutant mice by whole cell recordings, and the effect ..
- Interaction of Visual and Oculomotor Signals in CortexTirin Moore; Fiscal Year: 2009..saccades to pursue the relationship between saccade target selection and neural correlates of attention in visual cortex. Specifically, we will study the influence of saccade preparation on neural correlates of bottom-up and ..
- CRCNS: Neural Reprensentation of Hierarchical Visual Concepts in Natural ScenesAlan L Yuille; Fiscal Year: 2013..that sparse coding ideas can help predict receptive field properties of 'simple cells'in the visual cortex. This proposal has three stages...
- A molecular genetic analysis of cortical plasticityElly Nedivi; Fiscal Year: 2013..whether cpg15 is required for synapse and dendrite stabilization and experience-dependent plasticity during visual cortex development, and whether the source of CPG15 is thalamic or cortical...
- EXPERIMENTS ON THE DEVELOPMENT OF NEURAL PATHWAYSMartha Constantine Paton; Fiscal Year: 2010..maturation and plasticity in the superficial visual layers of the superior colliculus (sSC) and in the visual cortex (VC) neurons projecting to the sSC, the corticotectal projection (CTP)...
- Inhibitory plasticity in visual cortical circuitsArianna Maffei; Fiscal Year: 2013..2002;Hensch, 2005). In primary visual cortex, one of the best studied models for experience-dependent plasticity, synapse specific forms of plasticity such ..
- Disparity Processing in Human Visual CortexAnthony M Norcia; Fiscal Year: 2013....
- Organization and Function of Mouse Visual Cortical AreasEdward M Callaway; Fiscal Year: 2013..provided by applicant): Visual perception is mediated by complex interactions amongst neurons in the retina, visual cortex, and subcortical brain structures...
- Cross-modal changes in auditory cortex circuitry after visual deprivationEMILY ROSE PETRUS; Fiscal Year: 2013..These cross-modal changes are correlated with functional recruitment of the visual cortex for processing the remaining senses...
- Mechanisms and behavioral relevance of reward timing in the primary visual cortexEMMA BERYL ROACH; Fiscal Year: 2010..A novel form of reward-related plasticity was recently observed in the primary visual cortex (V1) of adult rats trained to associate visual stimulation with water reward: neurons that previously reported ..
- Neural Coding of Complex 3D ShapesCharles E Connor; Fiscal Year: 2013..neural basis of 3D object perception, memory, and cognition, by measuring neural responses in inferotemporal visual cortex (IT), memory-related perirhinal and entorhinal cortex (PR and ER), and decision-related dorsolateral ..
- Cortical representations and plasticity: Neurons and astrocytesMriganka Sur; Fiscal Year: 2011..Neurons in primary visual cortex (V1) are selective for multiple features of visual stimuli, for example orientation and spatial frequency, and ..
- CRCNS: Higher-order feature detection in olfactory bulbThomas A Cleland; Fiscal Year: 2013..output patterns selective for certain higher-order features of odors in the same sense that neurons in primary visual cortex are selective for higher-order visual features such as edge and orientation - that is, they reflect the co-..
- Developmental and experience-dependent changes in synaptic plasticityJACQUELINE DEMARCHENA; Fiscal Year: 2010..To discriminate subunit-specific functions, I will take advantage of the murine primary visual cortex, which not only undergoes this subunit transition, but is also heavily sculpted by NMDAR-dependent plasticity...
- In Vivo Imaging of Neuronal Plasticity in Mouse Visual CortexElly Nedivi; Fiscal Year: 2012..Using this system we have imaged and reconstructed the dendritic trees of neurons in visual cortex of thy1-GFP transgenic mice...
- Regulation of feedforward retinogeniculate development by cortical feedbackAndrew D Thompson; Fiscal Year: 2013..stage of development at this synapse that overlaps temporally with critical periods in visual cortex. This observation brings into question the traditional model of feed-forward development of sensory systems, ..
- Linking decisions and attention: Optogenetic tests in primate V1 and V4Hendrikje Nienborg; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Relevance to public health The "read-out" of visual cortex serves as a model system for interpretation, decision-making and reasoning...
- Assessing space and feature based attention with fMRI and multivoxel pattern analJohn Serences; Fiscal Year: 2010..techniques that are sensitive to changes in population response profiles across feature-selective regions of visual cortex. Specifically, we present a method for measuring feature-selective `tuning-functions'within very small ..
- Plasticity of the Visual CortexStelios Smirnakis; Fiscal Year: 2006..magnetic resonance (fMRI) to study the process of reorganization triggered by an acute retinal scotoma in the visual cortex of human and non-human primates (macaca mulatta)...
- ANATOMY OF IDENTIFIED CELL POPULATIONS IN VISUAL CORTEXBARBARA MC GUIRE; Fiscal Year: 1991The primate visual cortex is a layered structure, each layer containing many different types of neurons...
- REGULATION OF NEURAL PLASTICITY IN MATURING VISUAL CELLSTakuji Kasamatsu; Fiscal Year: 1993..Taking advantage of plasticity-enhancing effects of 1-noradrenaline (1- NA) directly infused into aplastic visual cortex of anesthetized and paralyzed kittens, we want to explore a new strategy with which we can quickly alter ..
- A comparative study of visual cortex in diurnal and nocturnal rodents.KATHARINE CAMPI; Fiscal Year: 2009The organization of rodent visual cortex is particularly relevant because rodents are the predominant model for most laboratory studies, including behavioral studies, whole animal physiology, slice physiology, anatomical and molecular ..
- ALTERED METABOLISM OF PRIMATE VISUAL CORTEX IN AMBLYOPIAJonathan Horton; Fiscal Year: 1990..However, little no direct information is available about the pathological changes that occur in the human visual cortex in amblyopia, in part because most of the experimental techniques developed for animal studies cannot be used ..
- VISUAL ADAPTATION AT MESOPIC LIGHT LEVELSArthur Shapiro; Fiscal Year: 2000..accepted that the clinical pathology in amblyopia involves a functional weakening of connections between the visual cortex and one or both of the eyes...
- PERIODIC EXTRINSIC CONNECTIONS IN VISUAL CORTEXKathleen Rockland; Fiscal Year: 1993Extrastriate visual cortex is made up of multiple areas differing in their topography, anatomical connectivity, and neuronal response properties...
- NEURAL BASIS OF VISUAL PATTERN APPEARANCEDavid Heeger; Fiscal Year: 2006Over the past few years, we have come to learn that early visual cortex does not act as a passive image processing machine simply devoted to representing bottom up sensory signals...