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| cerebral cortexSummarySummary: The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri. It reaches its highest development in man and is responsible for intellectual faculties and higher mental functions. Top Publications
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Publications
Neurophysiological and computational principles of cortical rhythms in cognitionXiao Jing Wang
Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Physiol Rev 90:1195-268. 2010..This review focuses on oscillations in the cerebral cortex that occur during cognition, in alert behaving conditions...
The representation of object concepts in the brainAlex Martin
Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Maryland 20892 1366, USA
Annu Rev Psychol 58:25-45. 2007..However, some property-based regions seem to show a categorical organization, thus providing evidence consistent with category-based, domain-specific formulations as well...- Human SII and posterior insula differently encode thermal laser stimuliMaud Frot
Institut National de la Santé et de la recherche médicale 342, Bron F 69677, France
Cereb Cortex 17:610-20. 2007.... - Simulation of robustness against lesions of cortical networksMarcus Kaiser
School of Computing Science, University of Newcastle, Claremont Tower, Newcastle upon Tyne NE1 7RU, UK
Eur J Neurosci 25:3185-92. 2007..This informs the understanding of the development of connectivity of the brain networks... - Identifying neural drivers with functional MRI: an electrophysiological validationOlivier David
INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
PLoS Biol 6:2683-97. 2008..As such, it has important implications for future studies on brain connectivity using functional neuroimaging... - Thresholding of statistical maps in functional neuroimaging using the false discovery rateChristopher R Genovese
Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Neuroimage 15:870-8. 2002..We demonstrate this approach using both simulations and functional magnetic resonance imaging data from two simple experiments... - Cortical surface-based analysis. I. Segmentation and surface reconstructionA M Dale
Massachusetts General Hosp Harvard Medical School, Building 149, Charlestown, Massachusetts, 02129, USA
Neuroimage 9:179-94. 1999Several properties of the cerebral cortex, including its columnar and laminar organization, as well as the topographic organization of cortical areas, can only be properly understood in the context of the intrinsic two-dimensional .. 
How do you feel--now? The anterior insula and human awarenessA D Bud Craig
Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
Nat Rev Neurosci 10:59-70. 2009..New findings suggest a fundamental role for the AIC (and the von Economo neurons it contains) in awareness, and thus it needs to be considered as a potential neural correlate of consciousness...- Mapping the structural core of human cerebral cortexPatric Hagmann
Department of Radiology, University Hospital Center and University of Lausanne CHUV, Lausanne, Switzerland
PLoS Biol 6:e159. 2008Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways... - Automated Talairach atlas labels for functional brain mappingJ L Lancaster
Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284, USA
Hum Brain Mapp 10:120-31. 2000..Additional suggested applications of the TD system include interactive labeling, anatomical grouping of activation foci, lesion-deficit analysis, and neuroanatomy education... - A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubsSophie Achard
Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
J Neurosci 26:63-72. 2006..Because the major hubs of this network are critical for cognition, its slow dynamics could provide a physiological substrate for segregated and distributed information processing... - The cortical organization of speech processingGregory Hickok
Department of Cognitive Sciences and The Center for Cognitive Neuroscience, University of California, Irvine, California 92697 5100, USA
Nat Rev Neurosci 8:393-402. 2007.... - A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networksDevarajan Sridharan
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:12569-74. 2008..Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control... - Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's diseaseRandy L Buckner
Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 29:1860-73. 2009..To identify regions of high connectivity in the human cerebral cortex, we applied a computationally efficient approach to map the degree of intrinsic functional connectivity .. - Predicting human resting-state functional connectivity from structural connectivityC J Honey
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
Proc Natl Acad Sci U S A 106:2035-40. 2009In the cerebral cortex, the activity levels of neuronal populations are continuously fluctuating... - Empathy for pain involves the affective but not sensory components of painTania Singer
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
Science 303:1157-62. 2004..We conclude that only that part of the pain network associated with its affective qualities, but not its sensory qualities, mediates empathy... - An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestRahul S Desikan
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
Neuroimage 31:968-80. 2006..the validity and reliability of an automated labeling system that we have developed for subdividing the human cerebral cortex on magnetic resonance images into gyral based regions of interest (ROIs)... - How do you feel? Interoception: the sense of the physiological condition of the bodyA D Craig
Nat Rev Neurosci 3:655-66. 2002..This system constitutes a representation of 'the material me', and might provide a foundation for subjective feelings, emotion and self-awareness... - Control of goal-directed and stimulus-driven attention in the brainMaurizio Corbetta
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nat Rev Neurosci 3:201-15. 2002..This ventral frontoparietal network works as a 'circuit breaker' for the dorsal system, directing attention to salient events. Both attentional systems interact during normal vision, and both are disrupted in unilateral spatial neglect... - The organization of the human cerebral cortex estimated by intrinsic functional connectivityB T Thomas Yeo
Harvard University, Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
J Neurophysiol 106:1125-65. 2011Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system... - Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" dataD Cordes
Department of Medical Physics, University of Wisconsin at Madison, 1300 University Ave, 1530 MSC, Madison, WI 53706, USA
AJNR Am J Neuroradiol 22:1326-33. 2001..In functionally connected regions, these low frequencies are characterized by a high degree of temporal coherence... - The small world of the cerebral cortexOlaf Sporns
Department of Psychology, Indiana University, Bloomington 47405, USA
Neuroinformatics 2:145-62. 2004While much information is available on the structural connectivity of the cerebral cortex, especially in the primate, the main organizational principles of the connection patterns linking brain areas, columns and individual cells have .. - Hemispheric asymmetry reduction in older adults: the HAROLD modelRoberto Cabeza
Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
Psychol Aging 17:85-100. 2002..They may have a cognitive or neural origin, and they may reflect regional or network mechanisms. The HAROLD model is a cognitive neuroscience model that integrates ideas and findings from psychology and neuroscience of aging... - Distinct brain networks for adaptive and stable task control in humansNico U F Dosenbach
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:11073-8. 2007..These two independent networks appear to operate on different time scales and affect downstream processing via dissociable mechanisms... - Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexGiorgio A Ascoli
Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
Nat Rev Neurosci 9:557-68. 2008..of terms to describe the anatomical, physiological and molecular features of GABAergic interneurons of the cerebral cortex. The resulting terminology might provide a stepping stone towards a future classification of these complex .. - Two systems of resting state connectivity between the insula and cingulate cortexKeri S Taylor
Division of Brain, Imaging and Behavior Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
Hum Brain Mapp 30:2731-45. 2009.... - Automatically parcellating the human cerebral cortexBruce Fischl
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
Cereb Cortex 14:11-22. 2004..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling... - Identification and classification of hubs in brain networksOlaf Sporns
Department of Psychological and Brain Sciences and Program in Cognitive Science, Indiana University, Bloomington, Indiana, United States of America
PLoS ONE 2:e1049. 2007Brain regions in the mammalian cerebral cortex are linked by a complex network of fiber bundles... - Neuronal oscillations in cortical networksGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark, NJ 07102, USA
Science 304:1926-9. 2004.... - Different frequencies for different scales of cortical integration: from local gamma to long range alpha/theta synchronizationA von Stein
Institute of Neuroinformatics, ETH University Zurich, Winterthurerstr 190, CH 8057, Zurich, Switzerland
Int J Psychophysiol 38:301-13. 2000..e. for top-down processing. We propose that large scale integration is performed by synchronization among neurons and neuronal assemblies evolving in different frequency ranges... - Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractographyGaolang Gong
Department of Biomedical Engineering, 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada
Cereb Cortex 19:524-36. 2009..to construct a macroscale anatomical network capturing the underlying common connectivity pattern of human cerebral cortex in a large sample of subjects (80 young adults) and further quantitatively analyzed its topological .. - The mismatch negativity (MMN) in basic research of central auditory processing: a reviewR Naatanen
Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
Clin Neurophysiol 118:2544-90. 2007..In addition, the MMN enables one to establish the brain processes underlying the initiation of attention switch to, conscious perception of, sound change in an unattended stimulus stream... - Neural mechanisms of autonomic, affective, and cognitive integrationHugo D Critchley
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London UCL Autonomic Unit, Institute of Cognitive Neuroscience, UCL, Queen Square, London WC1N 3BG, United Kingdom
J Comp Neurol 493:154-66. 2005..Generation of visceral autonomic correlates of control reinforce experiential engagement in simulatory models and underpin concepts such as somatic markers to bridge the dualistic divide... - Interoception: the sense of the physiological condition of the bodyA D Craig
Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ 85013, USA
Curr Opin Neurobiol 13:500-5. 2003.... - Breakdown of cortical effective connectivity during sleepMarcello Massimini
Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
Science 309:2228-32. 2005..Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity... - Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturerXiao Han
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Neuroimage 32:180-94. 2006In vivo MRI-derived measurements of human cerebral cortex thickness are providing novel insights into normal and abnormal neuroanatomy, but little is known about their reliability... - A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortexHiroki Taniguchi
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 71:995-1013. 2011A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling the diversity of GABAergic interneurons... - Probabilistic decision making by slow reverberation in cortical circuitsXiao Jing Wang
Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA
Neuron 36:955-68. 2002.... - A core system for the implementation of task setsNico U F Dosenbach
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Neuron 50:799-812. 2006..Prefrontal regions commonly related to task control carried task-set signals in a smaller subset of tasks and lacked convergence across signal types... - A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysisFlorian Kurth
C and O Vogt Institute of Brain Research, University Düsseldorf, Dusseldorf, Germany
Brain Struct Funct 214:519-34. 2010.... - The neural bases of momentary lapses in attentionD H Weissman
Center for Cognitive Neuroscience and Department of Psychiatry, Duke University, Durham, North Carolina 27708, USA
Nat Neurosci 9:971-8. 2006..Our findings provide a new, system-wide understanding of the patterns of brain activity that are associated with brief attentional lapses, which informs both theoretical and clinical models of goal-directed behavior... - The neural code between neocortical pyramidal neurons depends on neurotransmitter release probabilityM V Tsodyks
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
Proc Natl Acad Sci U S A 94:719-23. 1997..We conclude that by setting the rate of synaptic depression, release probability is an important factor in determining the neural code... - Mapping cortical change across the human life spanElizabeth R Sowell
University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Los Angeles, California 90095, USA
Nat Neurosci 6:309-15. 2003..Our findings also indicate that the posterior temporal cortices, primarily in the left hemisphere, which typically support language functions, have a more protracted course of maturation than any other cortical region... - Evidence for segregated and integrative connectivity patterns in the human Basal GangliaBogdan Draganski
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
J Neurosci 28:7143-52. 2008..We believe that this method can be used to examine pathophysiological concepts in a number of basal ganglia-related disorders... - Circuitry and functional aspects of the insular lobe in primates including humansJ R Augustine
Department of Cell Biology and Neuroscience, University of South Carolina School of Medicine, Columbia 29208, USA
Brain Res Brain Res Rev 22:229-44. 1996..Recent studies have expanded the role of the insula as a somatosensory area, emphasizing its multifaceted, sensory role. The idea of the insula as limbic integration cortex has been affirmed and its role in Alzheimer's disease suggested... - A common role of insula in feelings, empathy and uncertaintyTania Singer
Laboratory for Social and Neural Systems Research, University of Zurich, Switzerland
Trends Cogn Sci 13:334-40. 2009..Such mechanisms could facilitate affective learning and regulation of body homeostasis, and could also guide decision making in complex and uncertain environments... - Cortical midline structures and the selfGeorg Northoff
Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Trends Cogn Sci 8:102-7. 2004..All of these subfunctions are related to distinct regions within the CMS. This relationship between self-referential processing and CMS might provide novel insight into the neural correlates underlying the constitution of the self... - An insular view of anxietyMartin P Paulus
Department of Psychiatry, University of California, San Diego, La Jolla, California 92037, USA
Biol Psychiatry 60:383-7. 2006.... - What does the retrosplenial cortex do?Seralynne D Vann
School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK
Nat Rev Neurosci 10:792-802. 2009.... - Intellectual ability and cortical development in children and adolescentsP Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20182, USA
Nature 440:676-9. 2006..Here we demonstrate that the trajectory of change in the thickness of the cerebral cortex, rather than cortical thickness itself, is most closely related to level of intelligence... - Regional and progressive thinning of the cortical ribbon in Huntington's diseaseH D Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
Neurology 58:695-701. 2002.... - The dynamic brain: from spiking neurons to neural masses and cortical fieldsGustavo Deco
Institucio Catalana de Recerca i Estudis Avancats ICREA, Universitat Pompeu Fabra, Department of Technology, Computational Neuroscience, Barcelona, Spain
PLoS Comput Biol 4:e1000092. 2008..We argue that elaborating principled and informed models is a prerequisite for grounding empirical neuroscience in a cogent theoretical framework, commensurate with the achievements in the physical sciences... - Human insula activation reflects risk prediction errors as well as riskKerstin Preuschoff
Computation and Neural Systems Program and Division of Humanities and Social Sciences, Caltech, Pasadena, California 91125, USA
J Neurosci 28:2745-52. 2008..As such, our findings indicate that our understanding of the neural basis of reward anticipation under uncertainty needs to be expanded to include risk prediction... - Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculationMicaela Zonta
Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
Nat Neurosci 6:43-50. 2003..Taken together, our findings show that neuron-to-astrocyte signaling is a key mechanism in functional hyperemia... - Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampusTigwa H Davis
Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143 0730, USA
J Neurosci 28:4322-30. 2008.... - Geometrically accurate topology-correction of cortical surfaces using nonseparating loopsFlorent Segonne
CERTIS Laboratory, ENPC, 19 rue Nobel Cité Descartes, Champs sur Marne 77455, France
IEEE Trans Med Imaging 26:518-29. 2007..Applied to real data, our method provides topological corrections similar to those made by a trained operator... - Spontaneous cortical activity in awake monkeys composed of neuronal avalanchesThomas Petermann
Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:15921-6. 2009Spontaneous neuronal activity is an important property of the cerebral cortex but its spatiotemporal organization and dynamical framework remain poorly understood... - An integrated software suite for surface-based analyses of cerebral cortexD C Van Essen
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Med Inform Assoc 8:443-59. 2001..describe and illustrate an integrated trio of software programs for carrying out surface-based analyses of cerebral cortex. The first component of this trio, SureFit (Surface Reconstruction by Filtering and Intensity Transformations).. - Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activityA M Dale
Massachusetts General Hospital Nuclear Magnetic Resonance Center, Charlestown 02129, USA
Neuron 26:55-67. 2000..Repetition effects were observed in many of the same areas following this initial wave of activation, providing evidence for the involvement of feedback mechanisms in repetition priming... - Neurodevelopmental trajectories of the human cerebral cortexPhilip Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 28:3586-94. 2008Understanding the organization of the cerebral cortex remains a central focus of neuroscience. Cortical maps have relied almost exclusively on the examination of postmortem tissue to construct structural, architectonic maps... - A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortexDavid C Van Essen
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA
Neuroimage 28:635-62. 2005This report describes a new electronic atlas of human cerebral cortex that provides a substrate for a wide variety of brain-mapping analyses... - Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineageJessica A Gorski
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 22:6309-14. 2002..Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells... - Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2M Trommsdorff
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
Cell 97:689-701. 1999Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine kinases... - Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathologyRoberta Magliozzi
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Brain 130:1089-104. 2007..disability and death and more pronounced demyelination, microglia activation and loss of neurites in the cerebral cortex. Cortical demyelination in these SPMS cases was also more severe than in PPMS cases... - Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortexB Fischl
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
IEEE Trans Med Imaging 20:70-80. 2001Highly accurate surface models of the cerebral cortex are becoming increasingly important as tools in the investigation of the functional organization of the human brain... - Consciousness and complexityG Tononi
Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
Science 282:1846-51. 1998..Applying measures of neural integration and complexity, together with an analysis of extensive neurological data, leads to a testable proposal-the dynamic core hypothesis-about the properties of the neural substrate of consciousness... - Reelin and brain developmentFadel Tissir
Developmental Genetics Unit, Universite Catholique de Louvain, UCL 7382, 73 Avenue E Mounier, B1200 Brussels, Belgium
Nat Rev Neurosci 4:496-505. 2003 - In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2Benjamin R Arenkiel
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Neuron 54:205-18. 2007..Using focal illumination of the cerebral cortex and olfactory bulb, we demonstrate a highly reproducible, light-dependent activation of neurons and precise .. - The sleep slow oscillation as a traveling waveMarcello Massimini
Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Neurosci 24:6862-70. 2004..The orderly propagation of correlated activity along connected pathways may play a role in spike timing-dependent synaptic plasticity during sleep... - Cortical networks for working memory and executive functions sustain the conscious resting state in manB Mazoyer
Groupe d'Imagerie Neurofonctionnelle, UMR6095, CNRS, LEA, , , Paris, France
Brain Res Bull 54:287-98. 2001.... - The neuroscience of tinnitusJos J Eggermont
Department of Physiology and Biophysics, and Department of Psychology, University of Calgary, Alberta, Canada T2N 1N4
Trends Neurosci 27:676-82. 2004..Downregulation of intracortical inhibition induced by damage to the cochlea or to auditory projection pathways highlights neural processes that underlie the sensation of phantom sound... - Parvalbumin neurons and gamma rhythms enhance cortical circuit performanceVikaas S Sohal
Department of Bioengineering, Stanford University, Stanford, California 94305, USA
Nature 459:698-702. 2009.... - Three-dimensional probabilistic anatomical cranio-cerebral correlation via the international 10-20 system oriented for transcranial functional brain mappingMasako Okamoto
National Food Research Institute, Tsukuba 305 8642, Japan
Neuroimage 21:99-111. 2004..This study provided an initial step toward establishing a three-dimensional probabilistic anatomical platform that enables intra- and intermodal comparisons of NIRS and TMS brain imaging data... - Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phasesStephen C Noctor
Department of Neurology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York 10032, USA
Nat Neurosci 7:136-44. 2004..division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons .. - Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaT Nakagawa
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 403:98-103. 2000..Thus, caspase-12 mediates an ER-specific apoptosis pathway and may contribute to amyloid-beta neurotoxicity... - Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: From single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysisRainer Goebel
Brain Innovation, Maastricht, The Netherlands
Hum Brain Mapp 27:392-401. 2006..Using spatially and temporally unsmoothed data, this cortex-based analysis revealed comparable results but with a set of spatially more confined group clusters and more differential group region of interest time courses... - Neural simulation of action: a unifying mechanism for motor cognitionM Jeannerod
Institut des Sciences Cognitives, 67 Boulevard Pinel, Bron, 69675, France
Neuroimage 14:S103-9. 2001..The function of this process of simulation would be not only to shape the motor system in anticipation to execution, but also to provide the self with information on the feasibility and the meaning of potential actions... - Neuroanatomy of autismDavid G Amaral
The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
Trends Neurosci 31:137-45. 2008..Defined phenotypes in larger samples of children and well-characterized brain tissue will be necessary for clarification of the neuroanatomy of autism... - A theory of cortical responsesKarl Friston
The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Philos Trans R Soc Lond B Biol Sci 360:815-36. 2005..The final focus of this article is on perceptual learning as measured with the MMN and the implications for empirical studies of coupling among cortical areas using evoked sensory responses... - Neural activity in the human brain relating to uncertainty and arousal during anticipationH D Critchley
Wellcome Department of Cognitive Neurology, 12 Queen Square, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
Neuron 29:537-45. 2001..Our findings highlight distinct contributions of cognitive uncertainty and autonomic arousal to anticipatory neural activity in prefrontal cortex... - Grouping of brain rhythms in corticothalamic systemsM Steriade
Laboratory of Neurophysiology, Laval University, Faculty of Medicine, Quebec, Canada G1K 7P4
Neuroscience 137:1087-106. 2006.... - Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matricesO Sporns
The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
Cereb Cortex 10:127-41. 2000Neuroanatomy places critical constraints on the functional connectivity of the cerebral cortex. To analyze these constraints we have examined the relationship between structural features of networks (expressed as graphs) and the patterns .. - Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage tracesLaurent Badel
Laboratory of Computational Neuroscience, School of Computer and Communication Sciences and Brain Institute, Lausanne, Switzerland
J Neurophysiol 99:656-66. 2008..The predictions of the resulting model are in excellent agreement with experimental data and close to the intrinsic neuronal reproducibility to repeated stimuli... - Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticismMartin P Paulus
Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
Neuroimage 19:1439-48. 2003..These results are consistent with the hypothesis that insula activation serves as a critical neural substrate to instantiate aversive somatic markers that guide risk-taking decision-making behavior... - Mapping directed influence over the brain using Granger causality and fMRIAlard Roebroeck
Department of Cognitive Neuroscience, Faculty of Psychology, University of Maastricht, The Netherlands
Neuroimage 25:230-42. 2005..The presented exploratory approach of mapping influences between a region of interest and the rest of the brain can form a useful complement to existing models of effective connectivity... - GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1Stanislav Khirug
Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
J Neurosci 28:4635-9. 2008..Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters... - Perisomatic inhibitionTamas F Freund
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Neuron 56:33-42. 2007Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and ".. - Brain activity varies with modulation of dynamic pitch variance in sentence melodyMartin Meyer
Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
Brain Lang 89:277-89. 2004..Finally, it appears that brain areas which subserve speech (frontal operculum) and premotor functions (Rolandic operculum) coincidently support the processing of intonation contour in spoken sentence comprehension... - Psychological and neural mechanisms of the affective dimension of painD D Price
Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
Science 288:1769-72. 2000..Both direct and cortico-limbic pathways converge on the same anterior cingulate cortical and subcortical structures whose function may be to establish emotional valence and response priorities... - Thermosensory activation of insular cortexA D Craig
Division of Neurosurgery, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, Arizona 85013, USA
Nat Neurosci 3:184-90. 2000..Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices... - Excitatory actions of GABA in the cortexAllan T Gulledge
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Mills Road, Canberra, ACT 0200, Australia
Neuron 37:299-309. 2003..Our findings demonstrate that under certain circumstances GABA will have an excitatory role in synaptic integration in the cortex... - Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus networkP J Magill
Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Neuroscience 106:313-30. 2001..Furthermore, the relative contribution of rate and pattern to aberrant information coding is intimately related to the state of activation of the cerebral cortex. - Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI studyK Bornhovd
Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School, Germany
Brain 125:1326-36. 2002..e. 'uncertain' trials), the evoked signal changes were as great as in P3 trials, indicating that the amygdala is involved in coding 'uncertainty', as has been suggested previously in relation to classical conditioning... - From sensation to cognitionM M Mesulam
Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
Brain 121:1013-52. 1998..the primary sensory, upstream unimodal, downstream unimodal, heteromodal, paralimbic and limbic zones of the cerebral cortex. Connections from one zone to another are reciprocal and allow higher synaptic levels to exert a feedback (.. - Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortexF Conti
Institute of Human Physiology, University of Ancona, Italy
J Comp Neurol 396:51-63. 1998..membrane transporters (GATs) influence the action of GABA, the main inhibitory neurotransmitter in the human cerebral cortex. In this study, the cellular expression of GAT-1, the main cortical GABA transporter, was investigated in the .. - An intrinsic mechanism of corticogenesis from embryonic stem cellsNicolas Gaspard
IRIBHM Institute for Interdisciplinary Research, Universite Libre de Bruxelles ULB
Nature 455:351-7. 2008The cerebral cortex develops through the coordinated generation of dozens of neuronal subtypes, but the mechanisms involved remain unclear... - The determination of projection neuron identity in the developing cerebral cortexDino P Leone
Department of Biology, Stanford University, Stanford, CA 94305, USA
Curr Opin Neurobiol 18:28-35. 2008..Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the .. - Faces and objects in macaque cerebral cortexDoris Y Tsao
Athinoula A Martinos Center, Charlestown, Massachusetts 02129, USA
Nat Neurosci 6:989-95. 2003..Overall, our results suggest that humans and macaques share a similar brain architecture for visual object processing... - The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cellsYusuke Hirabayashi
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Development 131:2791-801. 2004..These findings may reveal broader and stage-specific physiological roles of Wnt signaling during neural development... - Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrievalBoyer D Winters
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neurosci Biobehav Rev 32:1055-70. 2008..Recent studies in rodents have begun to indicate the remarkable complexity of the neural substrates underlying this seemingly simple aspect of declarative memory... - Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortexJoshua T Trachtenberg
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Nature 420:788-94. 2002..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
Research Grants
- Basal Ganglia and Higher Cortical FunctionPeter L Strick; Fiscal Year: 2010..We and others have argued that abnormal activity in BG loops with the cerebral cortex could lead not only to motor disorders, but also to the behavioral symptoms associated with neuropsychiatric ..
- Cortical connections with the limbic territory of the basal gangliaMichelle Morrow; Fiscal Year: 2007..We and others have argued that abnormal activity in BG loops with the cerebral cortex could lead not only to motor disorders, but also to non-motor symptoms like those associated with Obsessive-..
- Inhibitory Interneurons in Tourette SyndromeFlora M Vaccarino; Fiscal Year: 2010..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- INTERACTION OF THE ESTROGEN RECEPTOR WITH DNAANN NARDULLI; Fiscal Year: 2010..thioredoxin reductase (TrxR), protein disulfide isomerase (PDI), and apurinic endonuclease 1 (APE1) in the cerebral cortex of C57BL/6 mice, (2) define whether estrogens and/or progestins alter the expression of oxidative stress ..
- Molecular Control of Progenitor Cell Polarity and Cortical NeurogenesisSong Hai Shi; Fiscal Year: 2010Proper formation of the cerebral cortex depends on an orderly production of a large number of neurons during embryonic development...
- Basal Ganglia and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2009..We and others have argued that abnormal activity in BG loops with the cerebral cortex could lead not only to motor disorders, but also to the behavioral symptoms associated with neuropsychiatric ..
- Structural determinants of DTI observations in developing cortex and white matterChristopher D Kroenke; Fiscal Year: 2010..Based on preliminary observations of changes in both WM and cerebral cortex FA in neonatally enucleated ferrets, we hypothesize that changes in WM FA arise from abnormalities of myelin/..
- Connexins in Neuronal and Glial Gap Junctions in the Central Nervous SystemJohn E Rash; Fiscal Year: 2010..throughout the complex circuitry of the mouse brain, to make detailed measurements of "mini" gap junctions in cerebral cortex and hippocampus of both mouse and human brain, and to identify the neuronal subtypes linked by "mini" gap ..
- Roles of Gsh1 & 2 genes in telencephalic neurogenesisKenneth Campbell; Fiscal Year: 2006..Two of the major telencephalic regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
- Correlation of Functional and Structural Units in Cerebral CortexNoam Harel; Fiscal Year: 2010Correlation of Functional and Structural Units in Cerebral Cortex This proposal is an expansion of our earlier NIH R21 project that explored the spatial relationship between functional magnetic resonance imaging (fMRI) signals and the ..
- MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURYRobert J Morecraft; Fiscal Year: 2010Stroke and traumatic brain injury often involve the cerebral cortex and are leading causes of functional disability collectively affecting greater than 2 million people per year in the United States...
- Correlation of Functional and Structural Units in Cerebral CortexNoam Harel; Fiscal Year: 2009Correlation of Functional and Structural Units in Cerebral Cortex This proposal is an expansion of our earlier NIH R21 project that explored the spatial relationship between functional magnetic resonance imaging (fMRI) signals and the ..
- Basal Ganglia, Cerebellum, and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2007..In contrast, the basal ganglia and cerebellum receive input from multiple areas of the cerebral cortex located in the frontal, parietal, and temporal lobes...
- Basal Ganglia, Cerebellum, and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2003..In contrast, the basal ganglia and cerebellum receive input from multiple areas of the cerebral cortex located in the frontal, parietal, and temporal lobes...
- Inhibitory Interneurons in Tourette SyndromeFlora Vaccarino; Fiscal Year: 2009..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- Inhibitory Interneurons in Tourette SyndromeFlora Vaccarino; Fiscal Year: 2007..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENTFlora Vaccarino; Fiscal Year: 2002The size of the cerebral cortex increases during mammalian evolution, underlying an increased complexity of cognitive operations and specialization of functions...
- In Vivo Imaging of Neuronal Plasticity in Mouse Visual CortexElly Nedivi; Fiscal Year: 2011..provide a baseline for future testing of molecules with therapeutic potential for promoting plasticity in the cerebral cortex. Such molecules may be used to compensate for insults or deterioration at multiple levels of the visual ..
- In Vivo Imaging of Neuronal Plasticity in Mouse Visual CortexElly Nedivi; Fiscal Year: 2010..provide a baseline for future testing of molecules with therapeutic potential for promoting plasticity in the cerebral cortex. Such molecules may be used to compensate for insults or deterioration at multiple levels of the visual ..
- Morphogenesis and function of the cerebral cortexFlora M Vaccarino; Fiscal Year: 2010..This proposal investigates how growth factors of the FGF family establish the primary structure of the cerebral cortex by controlling the genesis of cortical projection neurons from SVZ precursors...
- Sentinel cells that report neural and neurovascular signalingDavid Kleinfeld; Fiscal Year: 2007..addiction may be considerably increased if we know how neurotransmitter levels vary in select regions of cerebral cortex. In particular, it is believed that using addictive drug alters attentional processing mediated by ..
- Molecular Control of Progenitor Cell Polarity and Cortical NeurogenesisSong Hai Shi; Fiscal Year: 2009Proper formation of the cerebral cortex depends on an orderly production of a large number of neurons during embryonic development...
- Radial Glial Development And DifferentiationEva S Anton; Fiscal Year: 2010Polarized radial glial cells provide a template for the formation of cerebral cortex. Initially, they function as a source of new neurons and provide a permissive and instructive scaffold for neuronal migration...
- NEURAL GENE EXPRESSION IN SLEEP DEPRIVATION AND RECOVERYThomas S Kilduff; Fiscal Year: 2010..During the previous funding period, we identified a population of cells in the cerebral cortex that express the neuronal nitric oxide synthase (nNos) within which the transcription factor Fos is expressed ..
- RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXDavid C Van Essen; Fiscal Year: 2010..Much of this information pertains to the cerebral cortex and cerebellar cortex, the dominant structures of the human brain...
- Molecular Mechanisms of Cerebral Cortical PatterningElizabeth Grove; Fiscal Year: 2005The broad goal of this research is to identify the mechanisms that generate the area map of the mammalian cerebral cortex. Using the innovative method of in utero electroporation in living mouse embryos we have found evidence that the ..
- REGULATION IN MAMMALIAN NEURAL PROGENITOR CELLSQiang Lu; Fiscal Year: 2009..the growth and maintenance, differentiation, and migration of neural progenitor cells in the mammalian cerebral cortex. During development, neurons of the cerebral cortex arise from neural progenitor cells in the neuroepithelium,..
- CELL IDENTITY DETERMINATION IN CEREBRAL CORTEXChristopher A Walsh; Fiscal Year: 2010..Proper development of the cerebral cortex is essential for normal cognitive function, and requires the precise completion of a series of developmental ..
- Morphogenesis and function of the cerebral cortexFlora Vaccarino; Fiscal Year: 2007..focus on the role of Fibroblast Growth Factors (Fgf) receptors on the morphogenesis and function of the cerebral cortex, and particularly frontal regions, whose development is disrupted in schizophrenia...