putamen

Summary

Summary: The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus.

Top Publications

  1. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
  2. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
  3. ncbi fMRI reveals two distinct cerebral networks subserving speech motor control
    A Riecker
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Neurology 64:700-6. 2005
  4. ncbi Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings
    Ethan R Buch
    Section on Neurophysiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institute of Health, 49 Convent Drive, MSC 4401, Building 49/Room B1EE17, Bethesda, MD 20892-4401, USA
    Exp Brain Res 169:69-84. 2006
  5. ncbi Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning
    Masahiko Haruno
    Department of Cognitive Neuroscience Computational Neuroscience Labs, Advanced Telecommunication Research Institute, Sorakugun, Kyoto 619 0288, Japan
    J Neurophysiol 95:948-59. 2006
  6. ncbi The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen
    Yilin Li
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Neuropsychopharmacology 28:1082-5. 2003
  7. ncbi Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
  8. ncbi Somatotopic representation of nociceptive information in the putamen: an event-related fMRI study
    U Bingel
    NeuroImage Nord, Department of Neurology, Hamburg University Medical School, Germany
    Cereb Cortex 14:1340-5. 2004
  9. ncbi Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation
    X T Hu
    Neuropsychopharmacology Laboratory, Wayne State University School of Medicine, Lafayette Clinic, Detroit, Michigan 48207
    J Neurosci 10:2318-29. 1990
  10. ncbi Neuronal encoding of reward value and direction of actions in the primate putamen
    Yukiko Hori
    Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Neurophysiol 102:3530-43. 2009

Research Grants

  1. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
  2. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2010
  3. COCAINE INDUCED OPIOID, DOPAMINE AND BEHAVIORAL CHANGES
    ELLEN UNTERWALD; Fiscal Year: 2002
  4. Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2010
  5. Thalamostriatal System in Parkinsonism
    THOMAS N WICHMANN; Fiscal Year: 2010
  6. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2006
  7. NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 2001
  8. NEURAL CONTROL OF VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 1993
  9. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2007
  10. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2007

Detail Information

Publications184 found, 100 shown here

  1. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
    ..Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor...
  2. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
    ..has focussed recently on the possibility that the remaining serotonin neurons innervating striatum (caudate and putamen) might release dopamine as a 'false transmitter'--an action that could have both beneficial and harmful (e.g...
  3. ncbi fMRI reveals two distinct cerebral networks subserving speech motor control
    A Riecker
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Neurology 64:700-6. 2005
    ..The authors used fMRI to further examine the neural basis of speech motor control...
  4. ncbi Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings
    Ethan R Buch
    Section on Neurophysiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institute of Health, 49 Convent Drive, MSC 4401, Building 49/Room B1EE17, Bethesda, MD 20892-4401, USA
    Exp Brain Res 169:69-84. 2006
    ..activity patterns evolved at approximately the same time in both the dorsal premotor cortex (PMd) and the putamen. Here we report that, in both regions, the population activity for novel mappings came to resemble that for ..
  5. ncbi Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning
    Masahiko Haruno
    Department of Cognitive Neuroscience Computational Neuroscience Labs, Advanced Telecommunication Research Institute, Sorakugun, Kyoto 619 0288, Japan
    J Neurophysiol 95:948-59. 2006
    ..However, the putamen and caudate nucleus are embedded in distinct cortico-striatal loop circuits, predominantly connected to motor-..
  6. ncbi The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen
    Yilin Li
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Neuropsychopharmacology 28:1082-5. 2003
    ..of this study was two-fold: (1) to determine whether amphetamine has similar effects on MSNs in the caudate-putamen (CPu) and (2) to determine if this effect is localized to distal dendrites, the site of convergence of dopamine (..
  7. ncbi Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
    Functional neuroimaging and lesion studies have frequently reported thalamic and putamen activation during reading and speech production...
  8. ncbi Somatotopic representation of nociceptive information in the putamen: an event-related fMRI study
    U Bingel
    NeuroImage Nord, Department of Neurology, Hamburg University Medical School, Germany
    Cereb Cortex 14:1340-5. 2004
    ..functional magnetic resonance imaging (fMRI) to assess whether nociceptive information is represented in the putamen in a somatotopic manner...
  9. ncbi Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation
    X T Hu
    Neuropsychopharmacology Laboratory, Wayne State University School of Medicine, Lafayette Clinic, Detroit, Michigan 48207
    J Neurosci 10:2318-29. 1990
    ..were used to determine the sensitivities and interactions of D1 and D2 dopamine (DA) receptors in the caudate putamen (CPu) of rats that were denervated of DA by intraventricular injections of the catecholamine neurotoxin 6-..
  10. ncbi Neuronal encoding of reward value and direction of actions in the primate putamen
    Yukiko Hori
    Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Neurophysiol 102:3530-43. 2009
    ..To address this issue, we investigated the activities of presumed projection neurons in the putamen of macaque monkeys performing a visually instructed GO-NOGO button-press task for large and small rewards...
  11. ncbi Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study
    L W de Jong
    Department of Radiology, University Medical Center, Leiden, The Netherlands
    Brain 131:3277-85. 2008
    ..Using 3T 3D T1 MR images, volumes of nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen and thalamus were automatically calculated by the FMRIB's Integrated Registration and Segmentation Tool (FIRST)--..
  12. ncbi Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice
    Ilka Freiman
    , , D-79104 Freiburg i. Br, Germany
    J Physiol 575:789-806. 2006
    CB(1) cannabinoid receptors are expressed in many neurons in the caudate-putamen. However, it is not known how the activation of these receptors influences synaptic transmission between different neuron classes...
  13. ncbi Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006
    ..In the striatum, two distinct sets of the labeling were observed: one in the dorsal putamen, and the other in the ventral striatum (ventromedial putamen and nucleus accumbens)...
  14. ncbi Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Harvard Medical School Belmont 02178, USA
    Neurosci Lett 254:21-4. 1998
    Density of dopamine transporter (DAT) and serotonin transporter (5-HTT) membrane proteins in the caudate-putamen (CPu) and nucleus accumbens (NAc) of rat brain was assessed at seven ages at postnatal days (PD) 7-60, by in vitro ..
  15. ncbi Hyperintense putaminal rim at 3T reflects fewer ferritin deposits in the lateral marginal area of the putamen
    S Fujii
    Division of Radiology, Department of Pathophysiological and Therapeutic Science, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    AJNR Am J Neuroradiol 28:777-81. 2007
    ..The aim of this study was to clarify the cause of hyperintense putaminal rim (HPR) on the basis of 3T MR imaging-pathologic correlations...
  16. ncbi Specific neuromodulatory actions of amyloid-beta on dopamine release in rat nucleus accumbens and caudate putamen
    Elisa Mura
    Department of Experimental and Applied Pharmacology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 19:1041-53. 2010
    ..Abeta (1-40) on DA transmission to different release stimuli and to another dopaminergic brain area, the caudate putamen (CPu), in order to clarify whether the effect of the peptide is stimulus- or brain area-selective...
  17. ncbi Effects of acute cocaine on ERK and DARPP-32 phosphorylation pathways in the caudate-putamen of Fischer rats
    Wei Lun Sun
    Department of Psychology, Hunter College, City University of New York, 695 Park Ave, New York, NY 10021, USA
    Brain Res 1178:12-9. 2007
    ..element-binding protein (CREB) kinase, pp90 ribosomal S6 kinase (RSK), and c-Fos protein levels in the caudate/putamen of Fischer rats...
  18. ncbi Putamen FDOPA uptake and its relationship tot cognitive functioning in PD
    Marije van Beilen
    Department of Neurology, University Medical Center Groningen, The Netherlands
    J Neurol Sci 248:68-71. 2006
    ..The putamen is part of the motor loop, while the caudate nucleus is part of the motor loop but also of the cognitive loop...
  19. ncbi Reduced volume of the putamen in REM sleep behavior disorder patients
    Timothy M Ellmore
    Department of Neurosurgery, University of Texas Houston Medical School, MSB 7 044, 6431 Fannin St, Houston, TX 77030, USA
    Parkinsonism Relat Disord 16:645-9. 2010
    ..We hypothesized that REM sleep behavior disorder (RBD) patients, at risk for developing PD, will demonstrate a pattern of neuronal degeneration reflected in reduced striatal volumes on T1-weighted MRI...
  20. ncbi Caudate and putamen volumes in good and poor outcome patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 64:53-62. 2003
    ..The caudate nucleus and putamen were traced on axial slices from the most superior extent of the caudate to the most inferior point where the ..
  21. ncbi Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 113:241-5. 2009
    ..Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects...
  22. ncbi Cortical and putamen age-related changes in the microvessel density and astrocyte deficiency in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats
    Marie Françoise Ritz
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Curr Neurovasc Res 6:279-87. 2009
    ..SP-SHR) as a models for SVD, we analysed the effect of hypertension on the microvasculature in the cortex and putamen, and on its relationship with astrocytes in animals aged 2 to 9 months...
  23. ncbi Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey
    Hitoshi Kita
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 26:6554-62. 2006
    ..Here, we characterized the responses of pallidal neurons to single and burst stimulation of the putamen (Put) in awake monkeys...
  24. ncbi A follow-up study on 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen
    Anna Brück
    Turku PET Centre, University of Turku, Turku, Finland
    Mov Disord 24:1009-15. 2009
    ..Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms...
  25. ncbi Focal putamen lesions impair learning in rule-based, but not information-integration categorization tasks
    Shawn W Ell
    Helen Wills Neuroscience Institute and Psychology Department, University of California, Berkeley 94720 1650, United States
    Neuropsychologia 44:1737-51. 2006
    ..Patients with basal ganglia lesions centered in the putamen (6 left side, 1 right side) were tested on rule-based and information-integration visual categorization tasks...
  26. ncbi Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus
    Philip Seeman
    Department of Pharmacology, University of Toronto, King s College Circle, Medical Sciences Building, Toronto, Ontario, Canada M5S 1A8
    Synapse 60:205-11. 2006
    ..This method revealed that these two radioligands detected only D2 receptors in the dorsal putamen and the dorsal caudate nucleus, but detected a mixed population of two-thirds D2 and one-third D3 DA receptors in ..
  27. ncbi Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task
    M Inase
    Supermolecular Science Division, Electrotechnical Laboratory, Tsukuba, Japan
    Exp Brain Res 117:207-18. 1997
    Using multibarreled glass micropipettes, we recorded single-unit activity in the putamen, and iontopho retically applied D1 and D2 dopamine receptor agonists (SKF38393, quinpirole) and antagonists (SCH23390, sulpiride) while two monkeys ..
  28. ncbi Hemichorea-hemiballism associated with hyperintense putamen on T1-weighted MR images: an update and a hypothesis
    Din E Shan
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Acta Neurol Taiwan 13:170-7. 2004
    In 1998 some patients with hyperglycemia-related hemichorea-hemiballism have been reported with a hyperintense putamen on T1-weighted MR images, presumably resulting from petechial hemorrhage...
  29. ncbi Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
    To analyze the organization of corticostriatal motor inputs, we examined the neuronal responses in the putamen (Put) to stimulation in the primary motor cortex (MI) and the supplementary motor area (SMA)...
  30. ncbi Putamen coactivation during motor task execution
    William R Marchand
    Department of Veterans Affairs, VISN 19 MIRECC, Salt Lake City, Utah 84148, USA
    Neuroreport 19:957-60. 2008
    ..During the completion of a unilateral motor task with either hand, each putamen nucleus demonstrated strong coactivation with structures in both hemispheres...
  31. ncbi Dopamine D2 receptors are present in prefrontal cortical afferents and their targets in patches of the rat caudate-putamen nucleus
    Hong Wang
    Division of Neurobiology, Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 442:392-404. 2002
    ..neurons of the substantia nigra pars compacta preferentially terminate in patch-like regions within the caudate putamen nucleus (CPN)...
  32. ncbi Bilateral grey-matter increase in the putamen in primary blepharospasm
    T Etgen
    Department of Neurology, Technische Universitat Munchen, Munchen, Germany
    J Neurol Neurosurg Psychiatry 77:1017-20. 2006
    ..Primary blepharospasm is a focal dystonia characterised by excessive involuntary closure of the eyelids. The pathophysiology of primary blepharospasm is unresolved...
  33. ncbi The role of dominant striatum in language: a study using intraoperative electrical stimulations
    S Gil Robles
    Department of Neurosurgery, Hospital Clinico San Carlos, Universidad Complutense de Madrid, Spain
    J Neurol Neurosurg Psychiatry 76:940-6. 2005
    ..Intraoperative electrical stimulation during surgery for tumours involving the caudate nucleus or putamen in the dominant hemisphere might be illuminating...
  34. ncbi Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys
    Christian Pifl
    Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Neurochem Int 49:519-24. 2006
    ..We found that in the asymptomatic MPTP monkeys the DOPAC/DA ratios in putamen and caudate nucleus were shifted with high statistical significance 1.9-5...
  35. ncbi Magnetic resonance imaging-based volumetric analysis of basal ganglia nuclei and substantia nigra in patients with Parkinson's disease
    Dao-Ying Geng
    Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China
    Neurosurgery 58:256-62; discussion 256-62. 2006
    ..The whole brain volume and the volumes of the caudate, putamen, globus pallidus, and substantia nigra were calculated on three-dimensional reconstructed images...
  36. ncbi Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats
    W Hauber
    Department of Animal Physiology, Institute of Biology, University of Stuttgart, D 70550 Stuttgart, Germany
    Eur J Neurosci 14:1287-93. 2001
    ..by a systemic D2 receptor blockade with raclopride or by a bilateral blockade of D2 receptors in the caudate-putamen (CPu) with S(-)sulpiride...
  37. ncbi Disorganized somatotopy in the putamen of patients with focal hand dystonia
    C Delmaire
    Department of Neuroradiology, , Paris, France
    Neurology 64:1391-6. 2005
    ..Compared to healthy volunteer subjects, dystonic subjects had altered somatotopic organization in the left putamen, contralateral to the affected hand...
  38. ncbi A method to accurately inject tumor cells into the caudate/putamen nuclei of the mouse brain
    Shinya Yamada
    Department of Neurosurgery, Tokai University Oiso Hospital, Japan
    Tokai J Exp Clin Med 29:167-73. 2004
    ..To improve currently used techniques to implant tumor cells into the parenchyma of the mouse brain...
  39. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
    ..Analysis revealed that the putamen, the pulvinar and, to a smaller degree, the caudate nucleus are the subcortical structures typically associated ..
  40. ncbi Improved functional outcome in patients with hemorrhagic stroke in putamen and thalamus compared with those with stroke restricted to the putamen or thalamus
    I Miyai
    Department of Neurology, Toneyama National Hospital, Osaka, Japan
    Stroke 31:1365-9. 2000
    ..We analyzed the effect of late intensive inpatient rehabilitation on the functional outcome of patients with subcortical hemorrhagic stroke...
  41. ncbi Transcriptional changes in multiple system atrophy and Parkinson's disease putamen
    Ina R Vogt
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Exp Neurol 199:465-78. 2006
    ..in MSA, we chose CNS regions differentially affected in MSA and PD for comparative gene expression profiling: putamen, cerebellum and occipital cortex...
  42. ncbi Onset and rate of striatal atrophy in preclinical Huntington disease
    E H Aylward
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neurology 63:66-72. 2004
    ..Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms...
  43. ncbi Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen
    Michal T Krauze
    Department of Neurological Surgery, Laboratory of Molecular Therapeutics, University of California, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Exp Neurol 196:104-11. 2005
    ..MR method for monitoring CED delivery of liposomes in primate CNS allowed us to closely monitor infusions of putamen. Our findings indicate that CED in putamen is associated with perivascular transport of liposomes, throughout CNS ..
  44. ncbi Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
    Rita A Fuchs
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3584-8. 2006
    ..We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence...
  45. ncbi Encoding of direction and combination of movements by primate putamen neurons
    Yasumasa Ueda
    Faculty of Health and Sport Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan
    Eur J Neurosci 18:980-94. 2003
    ..We found that activity of 43% (30/69) and 60% (42/69) of putamen neurons was selective to the preprogrammed combination of movements and to the direction of the first movement...
  46. ncbi Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotype
    Jason M Uslaner
    Biopsychology and Neuroscience Programs, Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48019, USA
    J Neurochem 85:105-14. 2003
    ..c-fos mRNA in the subthalamic nucleus (STN) and in preproenkephalin mRNA-containing (ENK+) neurons in the caudate-putamen (CPu). When administered at home, however, low doses of amphetamine do not produce these effects...
  47. ncbi Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Synapse 48:157-69. 2003
    ..U34A (Affymetrix) oligonucleotide microarrays were used to analyze changes in gene expression in the caudate putamen (CPu) of Fischer rats induced by 1 and 3 days of "binge" cocaine (or saline) administration...
  48. ncbi Putamen lesions and the development of attention-deficit/hyperactivity symptomatology
    Jeffrey E Max
    University of California, San Diego and Children s Hospital and Health Center, USA
    J Am Acad Child Adolesc Psychiatry 41:563-71. 2002
    To investigate the association between focal stroke lesions of the putamen and either attention-deficit/hyperactivity disorder or traits of the disorder (ADHD/Traits).
  49. ncbi Response properties of neurons in the caudate-putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats
    E H Chudler
    Department of Anesthesiology, Box 356540, University of Washington, Seattle, WA 98195 6540, USA
    Brain Res 812:283-8. 1998
    To investigate the possible mechanisms by which neurons in the caudate-putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-..
  50. ncbi Involvement of the posteroventral caudate-putamen in memory consolidation in the Morris water maze
    B Setlow
    Department of Psychobiology, University of California, Irvine, Irvine California, 92697 3800, USA
    Neurobiol Learn Mem 71:240-7. 1999
    ..0 or 100.0 ng/side) or saline vehicle into the posteroventral caudate-putamen. Retention was tested 2 days later with a probe trial...
  51. ncbi High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice
    Timothy South
    Neurobiology Research Centre for Metabolic and Psychiatric Disorders, School of Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Neurochem Res 33:598-605. 2008
    ..increased D2 receptor and decreased DAT density in the dorsal and ventral parts of the caudal caudate putamen (D2: 32% and 35% respectively, DAT: 33.3% and 28.8% respectively) compared with low-fat diet...
  52. ncbi Transient adenosine efflux in the rat caudate-putamen
    Sylvia Cechova
    Department of Chemistry and Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurochem 105:1253-63. 2008
    ..In this study, we measured the subsecond time course of adenosine efflux in the caudate-putamen of anesthetized rats after a 1 s, high-frequency stimulation of dopamine neurons in the substantia nigra...
  53. ncbi Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys
    J J Soghomonian
    Centre de Recherche en Neurobiologie et Département d Anatomie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Synapse 27:122-32. 1997
    ..decarboxylase, GAD67 and GAD65, was analyzed by in situ hybridization histochemistry in the caudate nucleus and putamen of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated parkinsonian squirrel monkeys...
  54. ncbi Fronto-striatal connections in the human brain: a probabilistic diffusion tractography study
    Sandra E Leh
    Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada
    Neurosci Lett 419:113-8. 2007
    ..DTI) tractography to reconstruct neural connections between the frontal cortex and the caudate nucleus and putamen in vivo...
  55. ncbi Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task
    M G Oliveira
    Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil
    Neurobiol Learn Mem 68:32-41. 1997
    ..The aim of our study was to investigate which strategy is used by rats bearing hippocampal or caudate-putamen lesions in the acquisition of a left/right discrimination task in an elevated T-maze in both Situations 1 and 2...
  56. ncbi Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates
    Stephane Palfi
    Atomic Energy Commission, Institute of Biomedical Imaging, MIRCen, place du General Leclerc, Orsay, France
    Mol Ther 15:1444-51. 2007
    ..of lentiviral vectors encoding a fragment of mutated huntingtin (Htt171-82Q) into the dorsolateral sensorimotor putamen of macaques...
  57. ncbi Enhancement of the acoustic startle response by dopamine agonists after 6-hydroxydopamine lesions of the substantia nigra pars compacta: corresponding changes in c-Fos expression in the caudate-putamen
    E G Meloni
    The Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Brain Res 879:93-104. 2000
    ..of c-Fos protein as a marker of neuronal activity to assess any corresponding drug-induced changes in the caudate-putamen (CPu) after L-DOPA administration...
  58. ncbi Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
    James R Connor
    Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Brain 132:2403-12. 2009
    ..In this study, the substantia nigra and putamen were obtained at autopsy from individuals with primary RLS and a neurologically normal control group...
  59. ncbi NMDA receptor losses in putamen from patients with Huntington's disease
    A B Young
    Department of Neurology, University of Michigan, Ann Arbor 48109
    Science 241:981-3. 1988
    ..compared to benzodiazepine, gamma-aminobutyric acid (GABA), and muscarinic cholinergic receptor binding in the putamen and cerebral cortex of individuals with Huntington's disease (HD)...
  60. ncbi Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus
    J J Rodriguez
    Department of Neurology and Neuroscience, Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 21:823-33. 2001
    ..subtype 1 receptor (CB1R) and the mu-opioid receptor (muOR), in the striatal circuitry originating in the caudate putamen nucleus (CPN). Thus, the CB1R and muOR may show similar targeting in the CPN...
  61. ncbi Sensitized increase of period gene expression in the mouse caudate/putamen caused by repeated injection of methamphetamine
    T Nikaido
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
    Mol Pharmacol 59:894-900. 2001
    ..Although the caudate/putamen (CPu) expresses mPer1 and/or mPer2 mRNA, the function of these genes in this nucleus has not yet been elucidated...
  62. ncbi Distribution, projection and dopaminergic regulation of the neurokinin B mRNA-containing neurons of the rat caudate-putamen
    J M Burgunder
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892
    Neuroscience 32:323-35. 1989
    ..containing transcripts encoding neurokinin B, a member of the tachykinin family, were studied in the rat caudate-putamen using hybridization histochemistry...
  63. ncbi Executive dysfunction in early stages of Huntington's disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric study
    Alexander Peinemann
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munich, Germany
    J Neurol Sci 239:11-9. 2005
    ..The aim of the present study was to clarify if cognitive dysfunction in early stages of HD is correlated with loco-regional structural changes in 3D-MRI...
  64. ncbi Putamen hypertrophy in nondemented patients with human immunodeficiency virus infection and cognitive compromise
    J Mimi Boer Castelo
    Cognitive Neuroimaging Laboratory, Center for Memory and Brain, Boston University, 2 Cummington St, Room 109, Boston, MA 02215, USA
    Arch Neurol 64:1275-80. 2007
    ..Documented death and dysfunction of basal ganglia cells in patients seropositive for human immunodeficiency virus (HIV) suggest that the virus may cause structural compromise to these regions...
  65. ncbi Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis
    Y Zhang
    Department of Radiology, University of Calgary, Calgary, Canada
    Mult Scler 13:880-3. 2007
    ..5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study...
  66. ncbi Shape deformity of the corpus striatum in obsessive-compulsive disorder
    Jung Seok Choi
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Psychiatry Res 155:257-64. 2007
    ..We performed 3-D shape deformation analysis of the caudate nucleus, the putamen, and the globus pallidus in 36 patients with OCD and 36 healthy normal subjects...
  67. ncbi Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson's disease
    Michele T M Hu
    MRC Clinical Sciences Centre, Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:299-305. 2006
    ..All PD and parkin patients were discriminated from controls on the basis of caudate and putamen (18)F-dopa Ki reductions...
  68. ncbi Dopamine storage capacity in caudate and putamen of patients with early Parkinson's disease: correlation with asymmetry of motor symptoms
    Yoshitaka Kumakura
    PET Centre, Aarhus University Hospital, Denmark
    J Cereb Blood Flow Metab 26:358-70. 2006
    ..The estimates of k(loss) and EDV(2) were more sensitive for the discrimination of biochemical abnormality in the putamen of patients with early PD relative to healthy aged subjects, than was the conventional net influx estimate...
  69. ncbi Volumes, spatial extents and a probabilistic atlas of the human basal ganglia and thalamus
    R Laila Ahsan
    Division of Neuroscience, Faculty of Medicine, Imperial College, and MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:261-70. 2007
    ..Here, manual delineation of the central structures (thalamus; nucleus caudatus and accumbens; putamen, pallidum, substantia nigra) was performed on 30 high resolution MRIs of healthy young adults (15 female, median ..
  70. ncbi Restless legs syndrome and low brain iron levels in patients with haemochromatosis
    J Haba-Rubio
    Institute for Research in Neurosciences and Neuropsychiatry, Rouffach, France
    J Neurol Neurosurg Psychiatry 76:1009-10. 2005
    ..These results indicate that local brain iron deficiency may occur in patients with haemochromatosis and suggest a role for brain iron metabolism in the pathophysiology of RLS...
  71. ncbi Basal ganglia shape abnormalities in the unaffected siblings of schizophrenia patients
    Daniel Mamah
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 64:111-20. 2008
    ..Our aim was to test the hypothesis that abnormalities of basal ganglia structure are intrinsic features of schizophrenia by assessing basal ganglia volume and shape in the unaffected siblings of schizophrenia subjects...
  72. ncbi Nicotine and epibatidine alter differently nomifensine-elevated dopamine output in the rat dorsal and ventral striatum
    Sanna Janhunen
    Faculty of Pharmacy, Division of Pharmacology and Toxicology, University of Helsinki, P.O. Box 56, Viikinkaari 5, Helsinki FIN-00014, Finland
    Eur J Pharmacol 511:143-50. 2005
    ..Nomifensine (3 mg/kg) elevated extracellular dopamine in the caudate-putamen, and clearly more in the nucleus accumbens. In the caudate-putamen, nicotine (0.5 mg/kg) and epibatidine (0...
  73. ncbi Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
    ....
  74. ncbi Oral methylphenidate challenge selectively decreases putaminal T2 in healthy subjects
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 76:173-80. 2004
    ..Data were acquired from the caudate nucleus, putamen, and thalamus, using a 1.5 T MRI scanner at baseline and serially for 2 h following oral MPH administration (0...
  75. ncbi Mesostriatal and mesolimbic projections of midbrain neurons immunoreactive for estrogen receptor beta or androgen receptors in rats
    Lela M Creutz
    Graduate Program in Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794 5230, USA
    J Comp Neurol 476:348-62. 2004
    The dopamine (DA) inputs to the caudate putamen, the nucleus accumbens, and the amygdala in rats are sensitive to circulating estrogens and androgens...
  76. ncbi Altered white matter/gray matter proportions in the striatum of patients with schizophrenia: a volumetric MRI study
    Chiharu Tamagaki
    Human Brain Informatics, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 162:2315-21. 2005
    ..Magnetic resonance imaging scans were used to measure gray matter, white matter, and CSF volumes of the caudate, putamen, and nucleus accumbens in the left and the right hemispheres...
  77. ncbi Striatal dopaminergic activity (FDOPA-PET) associated with cognitive items of a depression scale (MADRS) in Parkinson's disease
    Janneke Koerts
    Department of Neurology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB, The Netherlands
    Eur J Neurosci 25:3132-6. 2007
    ..The striatal dopaminergic activity of patients was assessed with FDOPA-PET. Dopaminergic activity of the putamen and caudate nucleus was associated with MADRS total score and specifically with the symptom 'Concentration ..
  78. ncbi Time and decision making: differential contribution of the posterior insular cortex and the striatum during a delay discounting task
    Marc Wittmann
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 9116A, USA
    Exp Brain Res 179:643-53. 2007
    ..to the longer delays was associated with increased activation in the head of the left caudate nucleus and putamen. When individuals selected the delayed relative to the immediate reward, a strong activation was found in ..
  79. ncbi Evaluation of basal ganglia haemodynamic changes with perfusion-weighted magnetic resonance imaging in patients with Parkinson's disease
    F Gaudiello
    Dipartimento di Diagnostica per Immagini e Radiologia Interventistica, Universita degli Studi di Roma Tor Vergata, Italy
    Radiol Med 111:284-90. 2006
    ..The aim of our study was to assess the regional cerebral blood flow (rCBF) of basal ganglia and thalami in patients with Parkinson's disease (PD) using perfusion-weighted magnetic resonance imaging (PW-MRI)...
  80. ncbi The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea
    Philippe Huot
    Centre de Recherche Université, Laval Robert Giffard, Quebec, QC, Canada G1J 1Z4
    Brain 130:222-32. 2007
    ..striatum, but they abounded preferentially in the ventral portion of the structure and were more numerous in the putamen than in the caudate nucleus...
  81. ncbi Structural analysis of the basal ganglia in schizophrenia
    Daniel Mamah
    Department of Psychiatry, Washington University Medical School, St Louis, MO 63110, USA
    Schizophr Res 89:59-71. 2007
    ..Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as ..
  82. ncbi A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosis
    Jitendra Sharma
    Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham/Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 16:302-10. 2006
    ..Region-of-interest-derived MTR histograms for the caudate, putamen, globus pallidus, thalamus, and NAWM were obtained. Whole brain MTR was also measured...
  83. ncbi Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease
    J Spiegel
    Department of Neurology, Saarland University, Homburg Saar, Germany
    J Neural Transm 114:331-5. 2007
    ..We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding...
  84. ncbi Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques
    Zhiming Zhang
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Neuroimage 33:636-43. 2006
    ..The primary findings were (1) the putamen and substantia nigra (SN) but not the caudate nucleus displayed significant BOLD responses to these dopaminergic ..
  85. ncbi Net influx of plasma 6-[18F]fluoro-L-DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli
    Thomas Siessmeier
    Department of Nuclear Medicine, University of Mainz, Germany
    Eur J Neurosci 24:305-13. 2006
    ....
  86. ncbi Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndrome
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychiatry Res 154:181-90. 2007
    ..dimensional brain mapping (HDBM-LD) as a tool to characterize the basal ganglia (caudate, globus pallidus and putamen) and thalamus...
  87. ncbi Basal ganglia volumes in drug-naive first-episode schizophrenia patients before and after short-term treatment with either a typical or an atypical antipsychotic drug
    Andreas Glenthoj
    Danish Research Centre for Magnetic Resonance Imaging, University of Copenhagen, Hvidovre Hospital, Denmark
    Psychiatry Res 154:199-208. 2007
    ..Caudate nucleus, nucleus accumbens, and putamen volumes were measured...
  88. ncbi Sex differences in striatal dopamine release in healthy adults
    Cynthia A Munro
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biol Psychiatry 59:966-74. 2006
    ..Our findings indicate that future studies should control for sex and may have implications for the interpretation of sex differences in other illnesses involving the striatum...
  89. ncbi Attenuation of fluctuating striatal synaptic dopamine levels in patients with Parkinson disease in response to subthalamic nucleus stimulation: a positron emission tomography study
    Taro Nimura
    Department of Neurosurgery, Miyagi National Hospital, Japan
    J Neurosurg 103:968-73. 2005
    ..As part of an inquiry into the mechanism of STN DBS, the authors measured synaptic dopamine levels in the striatum by performing positron emission tomography (PET) with [11C]raclopride...
  90. ncbi Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder
    Mary S Ahn
    Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
    J Affect Disord 104:147-54. 2007
    ..The BG (caudate, putamen, globus pallidus, nucleus accumbens) is interconnected with limbic and prefrontal cortical structures and ..
  91. ncbi Quantification analysis of 123I-IPT single photon emission computed tomography uptake in the striatum of parkinsonism with the standard magnetic resonance template
    Rahyeong Juh
    Department of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 60:18-28. 2006
    ....
  92. ncbi Differential patterns of dopamine transporter loss in the basal ganglia of progressive supranuclear palsy and Parkinson's disease: analysis with [(123)I]IPT single photon emission computed tomography
    Joo-Hyuk Im
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Seoul 138-736, Korea
    J Neurol Sci 244:103-9. 2006
    ..the striatum correspond to the head of caudate nucleus (ROI 1), a transitional region between head of caudate and putamen (ROI 2), anterior putamen (ROI 3), and posterior putamen (ROI 4)...
  93. ncbi Relation between rotation in the 6-OHDA lesioned rat and dopamine loss in striatal and substantia nigra subregions
    M E Olds
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Synapse 59:532-44. 2006
    ..6-hydroxydopamine (6-OHDA) in the substantia nigra (SN) and the loss of DA in subregions of the SN and caudate-putamen (C/PUT) is not clear. Here this relation was examined in 23 rats classified as rotators to amphetamine (5 mg/kg)...
  94. ncbi Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies
    Kaveh M Koochesfahani
    Pacific Parkinson s Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Mov Disord 21:970-5. 2006
    ..Oral methylphenidate produced no significant change in extracellular DA levels in the putamen, as estimated by comparing changes in RAC binding at baseline and 1 hour following its administration in PD ..
  95. ncbi First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:279-89. 2008
    ..Binding potentials (BPs) were calculated for caudate, putamen, ventral striatum, and globus pallidus...
  96. ncbi Imaging in Parkinson's disease: the role of monoamines in behavior
    David J Brooks
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, United Kingdom
    Biol Psychiatry 59:908-18. 2006
    ..In Parkinson's disease (PD) posterior dorsal putamen DA terminals are initially targeted, the anterior putamen and head of caudate subsequently becoming affected...
  97. ncbi Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders
    M Mehmet Haznedar
    Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1505, New York, NY 10029, USA
    Am J Psychiatry 163:1252-63. 2006
    ..The authors used imaging studies to map volumetric and metabolic differences within the entire dorsoventral extent of the striatum and thalamus...
  98. ncbi Regional cerebral hyperperfusion with ictal dystonic posturing: ictal-interictal SPECT subtraction
    Eun Yeon Joo
    Department of Neurology, Samsung Medical Center and Center for Clinical Medicine, SBRI, Sungkyunkwn University School of Medicine, Seoul, Korea
    Epilepsia 45:686-9. 2004
    ..001, chi2, in caudate nucleus; 93.3% (14 of 15) versus 47.0% (eight of 17), p = 0.005, in putamen; and 80.0% (12 of 15) versus 41.2% (seven of 17), p = 0.026, in thalamus...
  99. ncbi Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption
    D L Daubert
    Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 816:8-16. 1999
    ..angiotensin II (Ang II) receptors was determined in three dopaminergic nerve terminal-rich brain regions (caudate putamen, nucleus accumbens, and ventral pallidum) of mice that were given either water (control) or 20% w/v ethanol (EtOH)..
  100. ncbi Decreased striatal dopamine D1 receptor-stimulated adenylyl cyclase activity in human methamphetamine users
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 160:896-903. 2003
    ..of dopamine stimulation of adenylyl cyclase activity was seen in the striatum (nucleus accumbens, caudate, and putamen) of the methamphetamine users...
  101. ncbi Basal Ganglia volumes in patients with Gilles de la Tourette syndrome
    Bradley S Peterson
    Division of Child and Adolescent Psychiatry, The Department of Psychiatry, New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York 10032, USA
    Arch Gen Psychiatry 60:415-24. 2003
    ....

Research Grants75

  1. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..received cultured mesencephalic tissue from four embryos along four 30 to 40 mm needle tracts bilaterally in the putamen. Control patients had burr holes but no actual implantations. No patients were immunosuppressed...
  2. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2010
    ..The major component of the basal ganglia, the striatum (or caudate-putamen) processes cortical inputs and subsequently regulates the output nuclei of the basal ganglia through two output ..
  3. COCAINE INDUCED OPIOID, DOPAMINE AND BEHAVIORAL CHANGES
    ELLEN UNTERWALD; Fiscal Year: 2002
    ..cyclase activity will be assessed by measuring the accumulation of cAMP in the nucleus accumbens, caudate putamen, and olfactory tubercle...
  4. Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2010
    ..One of the major telencephalic structures controlling these processes is the striatum (also known as the caudate-putamen)...
  5. Thalamostriatal System in Parkinsonism
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..Projections from the CM terminate in the putamen, completing a movement-related trans-thalamic feedback loop by which basal ganglia output may act to shape ..
  6. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2006
    ..regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
  7. NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 2001
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  8. NEURAL CONTROL OF VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 1993
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  9. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2007
    ..of conditioned fear whereas infusion of comparable doses into the central (Ce), basolateral (Bla) or caudate-putamen had no effect...
  10. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2007
    ..from bone marrow, referred to as mesenchymal stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  11. Neostriatal Visual Processing & Initiation of Movement
    Emad Eskandar; Fiscal Year: 2005
    ..The input nuclei of the basal ganglia in primates include the caudate and putamen. The output nuclei include the Gpi and the substantia nigra pars reticulata...
  12. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2010
    ..ganglia glucose metabolism and increased uptake of the DA precursor, [18F]fluorodopa (FDOPA), in caudate and putamen. To further characterize these IFN-alpha effects on DA pathways, we have recently developed an animal model of ..
  13. Schizophrenia Data and Software Tool Federation using BIRN Infrastructure
    Lei Wang; Fiscal Year: 2009
    ..e., hippocampus, amygdala, thalamus, caudate nucleus, nucleus accumbens, putamen and globus pallidus)...
  14. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  15. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2000
    ..determine if regional brain iron deficiency alters the release and re-uptake of DA in synaptosomes from caudate-putamen and to determine if the number of functioning transporter mRNA for these transporters are altered, 3) determine ..
  16. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  17. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  18. THE CONNECTIONAL ORGANIZATION OF THE THALAMUS
    JOHN HARTING; Fiscal Year: 2001
    The centromedian nucleus (CM-Pf) projects to striatal (caudate and putamen) neurons that are key components of basal ganglia pathways that regulate movement...
  19. Basal Ganglia Functions in Huntington's Disease: Genetic Mouse Models
    Elizabeth D Abercrombie; Fiscal Year: 2010
    ..of the brain are the cerebral cortex and the subcortical nuclei of the basal ganglia, in particular the caudate/putamen. There currently is no satisfactory therapy for the disease and the hope for a cure remains distant despite the ..
  20. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    VIRGINIA PICKEL; Fiscal Year: 2001
    Endogenous opiate peptides (enkephalins and dynorphin) within the dorsal (caudate-putamen nuclei, CPN) and ventral (nucleus accumbens septi) striatum have been implicated in motor and sensory responses to peripheral stimuli and in the ..