putamen

Summary

Summary: The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus.

Top Publications

  1. ncbi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008
  2. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
  3. pmc Differential recruitment of the sensorimotor putamen and frontoparietal cortex during motor chunking in humans
    Nicholas F Wymbs
    Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106, USA
    Neuron 74:936-46. 2012
  4. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
  5. pmc Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates
    Verginia C Cuzon Carlson
    Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
    Neuropsychopharmacology 36:2513-28. 2011
  6. pmc Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates
    Dali Yin
    Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, MCB 226, San Francisco, CA 94103, USA
    Neuroimage 54:S196-203. 2011
  7. ncbi Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
  8. ncbi Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning
    Masahiko Haruno
    Department of Cognitive Neuroscience Computational Neuroscience Labs, Advanced Telecommunication Research Institute, Sorakugun, Kyoto 619 0288, Japan
    J Neurophysiol 95:948-59. 2006
  9. pmc Basal ganglia surface morphology and the effects of stimulant medications in youth with attention deficit hyperactivity disorder
    Loren J Sobel
    Department of Psychiatry, New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 167:977-86. 2010
  10. ncbi Sensitized increase of period gene expression in the mouse caudate/putamen caused by repeated injection of methamphetamine
    T Nikaido
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
    Mol Pharmacol 59:894-900. 2001

Detail Information

Publications268 found, 100 shown here

  1. ncbi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008
    ..This approach holds promise for studying basal ganglia dysfunction in clinical disorders...
  2. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
    ..Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor...
  3. pmc Differential recruitment of the sensorimotor putamen and frontoparietal cortex during motor chunking in humans
    Nicholas F Wymbs
    Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106, USA
    Neuron 74:936-46. 2012
    ..Activity in the bilateral sensorimotor putamen positively correlated with chunk concatenation, whereas a left-hemisphere frontoparietal network was correlated ..
  4. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
    ..Analysis revealed that the putamen, the pulvinar and, to a smaller degree, the caudate nucleus are the subcortical structures typically associated ..
  5. pmc Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates
    Verginia C Cuzon Carlson
    Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
    Neuropsychopharmacology 36:2513-28. 2011
    ..protocol, we found a selective increase in dendritic spine density and enhanced glutamatergic transmission in the putamen, but not in the caudate nucleus...
  6. pmc Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates
    Dali Yin
    Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, MCB 226, San Francisco, CA 94103, USA
    Neuroimage 54:S196-203. 2011
    ..we retrospectively analyzed MRI of 25 convection-enhanced delivery (CED) infusions with MRI contrast into the putamen of non-human primates (NHP)...
  7. ncbi Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
    To analyze the organization of corticostriatal motor inputs, we examined the neuronal responses in the putamen (Put) to stimulation in the primary motor cortex (MI) and the supplementary motor area (SMA)...
  8. ncbi Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning
    Masahiko Haruno
    Department of Cognitive Neuroscience Computational Neuroscience Labs, Advanced Telecommunication Research Institute, Sorakugun, Kyoto 619 0288, Japan
    J Neurophysiol 95:948-59. 2006
    ..However, the putamen and caudate nucleus are embedded in distinct cortico-striatal loop circuits, predominantly connected to motor-..
  9. pmc Basal ganglia surface morphology and the effects of stimulant medications in youth with attention deficit hyperactivity disorder
    Loren J Sobel
    Department of Psychiatry, New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 167:977-86. 2010
    ..The authors examined the morphologic features of the basal ganglia nuclei (caudate, putamen, and globus pallidus) in children with ADHD.
  10. ncbi Sensitized increase of period gene expression in the mouse caudate/putamen caused by repeated injection of methamphetamine
    T Nikaido
    Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
    Mol Pharmacol 59:894-900. 2001
    ..Although the caudate/putamen (CPu) expresses mPer1 and/or mPer2 mRNA, the function of these genes in this nucleus has not yet been elucidated...
  11. ncbi Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain
    Piotr Hadaczek
    Laboratory of Molecular Therapeutics, Neurological Surgery, University of California, San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 17:291-302. 2006
    ..The TK group consisted of three monkeys that received bilateral CED infusion of AAV2-TK into the putamen; one side in all three monkeys was coinfused with heparin...
  12. ncbi Mu-opioid and NMDA-type glutamate receptors are often colocalized in spiny neurons within patches of the caudate-putamen nucleus
    H Wang
    Division of Neurobiology, Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 412:132-46. 1999
    The patch compartments of the caudate-putamen nucleus (CPN) are enriched in mu-opioid receptors (MORs) and have been recently implicated in reward-related behaviors...
  13. ncbi Convective delivery of glial cell line-derived neurotrophic factor in the human putamen
    Paul F Morrison
    Division of Bioengineering and Physical Science, Office of Research Services, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 107:74-83. 2007
    ..The authors conducted an analysis of the distribution of glial cell line-derived neurotrophic factor in the human striatum following convection-enhanced delivery...
  14. ncbi Impairment of motor imagery in putamen lesions in humans
    C R Li
    Medical Research Center and Department of Psychiatry, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kwei Shan, 333, Tao Yuan, Taiwan
    Neurosci Lett 287:13-6. 2000
    Patients with putamen or cortical lesions participated in a first- and third-person movement imagery task, each primarily engaging kinesthetic and visual imagery...
  15. ncbi Differential roles of caudate nucleus and putamen during instrumental learning
    Andrea Brovelli
    Institut de Neurosciences Cognitives de la Mediterranee, UMR 6193, CNRS and Université Aix Marseille II, Marseille, France
    Neuroimage 57:1580-90. 2011
    ..The anterior caudate nucleus integrates information about performance and cognitive control demands, whereas the putamen tracks how likely the conditioning stimuli lead to correct response...
  16. pmc Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings
    Ethan R Buch
    Section on Neurophysiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institute of Health, 49 Convent Drive, MSC 4401, Building 49 Room B1EE17, Bethesda, MD 20892 4401, USA
    Exp Brain Res 169:69-84. 2006
    ..activity patterns evolved at approximately the same time in both the dorsal premotor cortex (PMd) and the putamen. Here we report that, in both regions, the population activity for novel mappings came to resemble that for ..
  17. ncbi Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation
    X T Hu
    Neuropsychopharmacology Laboratory, Wayne State University School of Medicine, Lafayette Clinic, Detroit, Michigan 48207
    J Neurosci 10:2318-29. 1990
    ..were used to determine the sensitivities and interactions of D1 and D2 dopamine (DA) receptors in the caudate putamen (CPu) of rats that were denervated of DA by intraventricular injections of the catecholamine neurotoxin 6-..
  18. ncbi Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD
    M F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neurology 58:575-80. 2002
    ..However, it is currently unknown whether diffusion-weighted imaging (DWI) discriminates these disorders...
  19. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..It was hypothesized that putamen D(2) binding potential would be higher during major depressive episodes featuring motor retardation.
  20. ncbi Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study
    Hanik K Yoo
    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Eur J Neurosci 22:2089-94. 2005
    ..Gray matter volumes of bilateral putamen were decreased in panic subjects relative to healthy comparison subjects (corrected P < 0.05)...
  21. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
    ..has focussed recently on the possibility that the remaining serotonin neurons innervating striatum (caudate and putamen) might release dopamine as a 'false transmitter'--an action that could have both beneficial and harmful (e.g...
  22. ncbi Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Neurosci 24:3554-62. 2004
    ..however, the effects of cocaine intensified and spread dorsally to include most aspects of both caudate and putamen. Early experiences with cocaine, then, involve mainly the limbic domain, an area that mediates motivational and ..
  23. ncbi Representation of action-specific reward values in the striatum
    Kazuyuki Samejima
    Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619 0288 Kyoto, Japan
    Science 310:1337-40. 2005
    ..Fewer neurons were tuned to relative values or action choice. These results suggest representation of action values in the striatum, which can guide action selection in the basal ganglia circuit...
  24. ncbi Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006
    ..In the striatum, two distinct sets of the labeling were observed: one in the dorsal putamen, and the other in the ventral striatum (ventromedial putamen and nucleus accumbens)...
  25. pmc Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice
    Ilka Freiman
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, D 79104 Freiburg i Br, Germany
    J Physiol 575:789-806. 2006
    CB(1) cannabinoid receptors are expressed in many neurons in the caudate-putamen. However, it is not known how the activation of these receptors influences synaptic transmission between different neuron classes...
  26. ncbi Somatotopic representation of nociceptive information in the putamen: an event-related fMRI study
    U Bingel
    NeuroImage Nord, Department of Neurology, Hamburg University Medical School, Germany
    Cereb Cortex 14:1340-5. 2004
    ..functional magnetic resonance imaging (fMRI) to assess whether nociceptive information is represented in the putamen in a somatotopic manner...
  27. ncbi fMRI reveals two distinct cerebral networks subserving speech motor control
    A Riecker
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Neurology 64:700-6. 2005
    ..The authors used fMRI to further examine the neural basis of speech motor control...
  28. ncbi Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease
    Elke Hattingen
    Institute of Neuroradiology, J W Goethe University Schleusenweg 2 16, 60528 Frankfurt Main, Germany
    Brain 132:3285-97. 2009
    ..In the putamen and midbrain of both Parkinson's disease groups, we found a bilateral reduction of high-energy phosphates such as ..
  29. pmc Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study
    L W de Jong
    Department of Radiology, University Medical Center, Leiden, The Netherlands
    Brain 131:3277-85. 2008
    ..Using 3T 3D T1 MR images, volumes of nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen and thalamus were automatically calculated by the FMRIB's Integrated Registration and Segmentation Tool (FIRST)--..
  30. ncbi Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing
    B Jill Venton
    Department of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    J Neurochem 87:1284-95. 2003
    ..These simulations show that synchronous phasic firing can produce spatially and temporally heterogeneous concentration profiles whereas asynchronous tonic firing elicits uniform, steady-state dopamine concentrations...
  31. ncbi Onset and rate of striatal atrophy in preclinical Huntington disease
    E H Aylward
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neurology 63:66-72. 2004
    ..Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms...
  32. pmc Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
    Rita A Fuchs
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3584-8. 2006
    ..We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence...
  33. ncbi Foot, hand, face and eye representation in the human striatum
    Emmanuel Gerardin
    Service Hospitalier Frederic Joliot, Department of Medical Research, CEA, Orsay, France
    Cereb Cortex 13:162-9. 2003
    ..For foot, hand and face movements, striatal activation was mainly found in the putamen with a somatotopical organization, the foot area being dorsal, the face area more ventral and medial, the hand ..
  34. pmc Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
    James R Connor
    Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Brain 132:2403-12. 2009
    ..In this study, the substantia nigra and putamen were obtained at autopsy from individuals with primary RLS and a neurologically normal control group...
  35. ncbi Increased activity of mitochondrial aldehyde dehydrogenase (ALDH) in the putamen of individuals with Alzheimer's disease: a human postmortem study
    Tanja Maria Michel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Alzheimers Dis 19:1295-301. 2010
    ..We found that the mitochondrial ALDH activity was significantly increased only in the putamen of patients suffering from AD compared to controls...
  36. pmc Gene expression profiling analysis of the putamen for the investigation of compensatory mechanisms in Parkinson's disease
    Lianbo Gao
    Department of Neurology, the Fourth Affiliated Hospital of China Medical University, NO, 4 chongshan Road, huanggu Area, Shenyang 110032, Liaoning, China
    BMC Neurol 13:181. 2013
    ..Therefore, identification of gene expression alterations in the striatum will greatly assist the development of novel therapy strategies...
  37. ncbi Quantitative morphology of the caudate and putamen in patients with cocaine dependence
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 158:486-9. 2001
    ....
  38. ncbi Magnetic resonance imaging-based volumetric analysis of basal ganglia nuclei and substantia nigra in patients with Parkinson's disease
    Dao Ying Geng
    Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China
    Neurosurgery 58:256-62; discussion 256-62. 2006
    ..This correlation may provide valuable information in early diagnosis of PD...
  39. pmc Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Mol Ther 19:1048-57. 2011
    ..direct infusion of neurotrophic therapies for Parkinson's disease (PD) have suffered from poor coverage of the putamen. The planned use of a novel interventional-magnetic resonance imaging (iMRI) targeting system for achieving ..
  40. ncbi Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:847-52. 2006
    ..neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while ..
  41. ncbi Striatal subregional 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease: a two-year follow-up study
    Anna Brück
    Turku PET Center, University of Turku, Turku, Finland
    Mov Disord 21:958-63. 2006
    ..shows that the F-dopa uptake in unmedicated early PD is most severely decreased in the dorsal part of caudal putamen but significant decrease can be seen throughout the striatum compared with controls...
  42. pmc Striatal functional alteration during incentive anticipation in pediatric anxiety disorders
    Amanda E Guyer
    Department of Human and Community Development, Center for Mind and Brain, University of California Davis, Davis, CA, USA
    Am J Psychiatry 169:205-12. 2012
    ..The present study compares striatal function in healthy adolescents, adolescents with social phobia, and adolescents with generalized anxiety disorder...
  43. ncbi The neural basis of central proprioceptive processing in older versus younger adults: an important sensory role for right putamen
    Daniel J Goble
    Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, Department of Biomedical Kinesiology, K U Leuven, Belgium
    Hum Brain Mapp 33:895-908. 2012
    ..A significant decrease in neural activity was also found in a cluster of right putamen voxels for the older age group when compared with the younger age group...
  44. pmc Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices
    Carrie E John
    Wake Forest University School of Medicine, Department of Physiology and Pharmacology, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuropharmacology 52:1596-605. 2007
    ..and fenfluramine on dopamine and serotonin uptake following electrically stimulated release in mouse caudate-putamen and substantia nigra pars reticulata slices...
  45. pmc Mitochondrial abnormalities in the putamen in Parkinson's disease dyskinesia
    Alipi V Naydenov
    Department of Pharmacology and Psychiatry, Vanderbilt University, Nashville, TN, 37232 8548, USA
    Acta Neuropathol 120:623-31. 2010
    ..We hypothesized that bioenergetic function in the putamen might play a crucial role in the development of dyskinesias...
  46. ncbi Disorganized somatotopy in the putamen of patients with focal hand dystonia
    C Delmaire
    Department of Neuroradiology, Hopital de la Pitie Salpetriere, Paris, France
    Neurology 64:1391-6. 2005
    ..To explore the selectivity of neuronal somatotopic representation in the striatum of patients with unilateral task-specific dystonia of the right arm...
  47. pmc Inactivation of the putamen selectively impairs reward history-based action selection
    Manabu Muranishi
    Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Exp Brain Res 209:235-46. 2011
    ..The present study examined the effect of inactivation of the putamen via local injection of the GABA(A) receptor agonist muscimol in monkeys engaged in a manual reward-based multi-..
  48. ncbi The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea
    Philippe Huot
    Centre de Recherche Université, Laval Robert Giffard, Quebec, QC, Canada G1J 1Z4
    Brain 130:222-32. 2007
    ..striatum, but they abounded preferentially in the ventral portion of the structure and were more numerous in the putamen than in the caudate nucleus...
  49. pmc Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum
    Waldy San Sebastián
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 23:210-7. 2012
    ..mainstay drug, l-DOPA, one promising approach has been to use gene therapy to restore AADC activity in the human putamen and thereby restore normal l-DOPA response in patients with PD...
  50. ncbi Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens
    Devadoss J Samuvel
    Division of Neuroscience Research, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 325:293-301. 2008
    ..Using ex vivo caudate putamen (CPu) and nucleus accumbens (NAcc) synaptosomal preparations, we found that DA uptake was significantly higher in ..
  51. pmc Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy
    Mizuki Ito
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 78:722-8. 2007
    ....
  52. ncbi Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ..alters the metabolic ratios NAA/Cho, NAA/Cr, Cho/Cr and Ins/Cr in the left dorsolateral prefrontal cortex, anterior cingulate cortex, and putamen in healthy subjects and psychiatric patients irrespective of clinical diagnosis.
  53. ncbi Increased xanthine oxidase in the thalamus and putamen in depression
    Tanja Maria Michel
    Neurochemistry Laboratory, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 11:314-20. 2010
    ..We measured the XO activity in following brain areas: hippocampus, regio entorhinalis, thalamus, putamen and caudate nucleus...
  54. ncbi Specific neuromodulatory actions of amyloid-beta on dopamine release in rat nucleus accumbens and caudate putamen
    Elisa Mura
    Department of Experimental and Applied Pharmacology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 19:1041-53. 2010
    ..Abeta (1-40) on DA transmission to different release stimuli and to another dopaminergic brain area, the caudate putamen (CPu), in order to clarify whether the effect of the peptide is stimulus- or brain area-selective...
  55. ncbi Functional neural correlates of psychometric schizotypy: an fMRI study of antisaccades
    Désirée S Aichert
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Psychophysiology 49:345-56. 2012
    ..reduced blood oxygenation level dependent signal and higher schizotypy were found during antisaccades in the putamen, thalamus, cerebellum, and visual cortex and during prosaccades in the visual cortex, supplementary eye field, ..
  56. ncbi Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation
    Belen Gago
    Department of Cell Biology, School of Science, University of Malaga, 29071 Malaga, Spain
    Brain Res 1407:47-61. 2011
    ..induces a down-regulation of the μ opioid receptor (MOR) in the striosomal compartment of the rat caudate putamen (CPu), suggesting a striosomal D(4)R/MOR receptor interaction in line with their high co-distribution in this ..
  57. ncbi Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: a resting-state functional magnetic resonance imaging study
    Bo Zhou
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Mov Disord 25:1226-31. 2010
    ..The whole brain analysis indicated that the patient group had significantly increased ALFF in the bilateral putamen (P < 0.005) than normal control. fMRI could be useful to evaluate PKC with negative conventional imaging...
  58. pmc [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen
    Jinbin Xu
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Synapse 64:449-59. 2010
    ..A mathematical model for calculating the absolute densities of dopamine D(2) and D(3) receptors based on the in vitro receptor binding data of [3H]WC-10 and [3H]raclopride was developed...
  59. ncbi Hyperintense putaminal rim sign is not a hallmark of multiple system atrophy at 3T
    Wei Hsing Lee
    Department of Radiology, Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, Republic of China
    AJNR Am J Neuroradiol 26:2238-42. 2005
    ..We hypothesized that the HPR sign is not an exclusive hallmark of MSA at a high magnetic field strength, but rather may be a normal finding...
  60. pmc AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters
    Laura M Sanftner
    Avigen Inc, 1301 Harbor Bay Parkway, Alameda, CA 94502, USA
    Exp Neurol 194:476-83. 2005
    ..AAV2 encoding the human aromatic l-amino acid decarboxylase gene (AAV-hAADC-2) was infused into the putamen of 4 normal rhesus monkeys as a supportive study for a clinical trial in Parkinson's disease (PD) patients...
  61. ncbi Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias
    Frederic Calon
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec, Canada
    J Neuropathol Exp Neurol 61:186-96. 2002
    ..A significant increase of preproenkephalin messenger RNA levels was observed in the lateral putamen of dyskinetic patients in comparison to controls (+210%; p < 0...
  62. ncbi Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Harvard Medical School Belmont 02178, USA
    Neurosci Lett 254:21-4. 1998
    Density of dopamine transporter (DAT) and serotonin transporter (5-HTT) membrane proteins in the caudate-putamen (CPu) and nucleus accumbens (NAc) of rat brain was assessed at seven ages at postnatal days (PD) 7-60, by in vitro ..
  63. ncbi The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen
    Yilin Li
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Neuropsychopharmacology 28:1082-5. 2003
    ..of this study was two-fold: (1) to determine whether amphetamine has similar effects on MSNs in the caudate-putamen (CPu) and (2) to determine if this effect is localized to distal dendrites, the site of convergence of dopamine (..
  64. ncbi Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: relation to estimated iron and water contents
    N Gelman
    Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, Michigan 48202, USA
    Magn Reson Med 45:71-9. 2001
    ..567 +/- 0.020 sec(-1)), caudate head (0.675 +/- 0.019 sec(-1)), putamen (0.749 +/- 0.023 sec(-1)), substantia nigra (0.873 +/- 0.037 sec(-1)), globus pallidus (0.960 +/- 0...
  65. ncbi Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study
    Nicole Praschak-Rieder
    Vivian M Rakoff Positron Emission Tomography Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 62:327-31. 2007
    ..We examined the possible influence of the long (A/G) variant on 5-HTT density in the living human brain using 3-(11)C-amino-4-(2-dimethylaminomethylphenyl-sulfanyl) benzonitrile ([(11)C]DASB) positron emission tomography...
  66. ncbi Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen
    Michal T Krauze
    Department of Neurological Surgery, Laboratory of Molecular Therapeutics, University of California, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Exp Neurol 196:104-11. 2005
    ..MR method for monitoring CED delivery of liposomes in primate CNS allowed us to closely monitor infusions of putamen. Our findings indicate that CED in putamen is associated with perivascular transport of liposomes, throughout CNS ..
  67. pmc Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study
    Ji H Ko
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Eur J Neurosci 28:2147-55. 2008
    ..cTBS of the left DLPFC impaired MCST performance and dopamine release in the ipsilateral caudate-anterior putamen and contralateral caudate nucleus, as compared to cTBS of the vertex (control)...
  68. pmc Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning
    M G Packard
    Department of Psychology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 96:12881-6. 1999
    ..was used to examine the hypothesis that posttraining neurochemical manipulation of the hippocampus or caudate-putamen can bias an animal toward the use of a specific memory system...
  69. pmc Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 113:241-5. 2009
    ..Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects...
  70. pmc The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions
    Christopher J Starr
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Brain 134:1987-2004. 2011
    ..These interactions occur via cortico-basal ganglia-thalamo-cortical loops. The putamen is one of the major sites of cortical input into basal ganglia loops and is frequently activated during pain...
  71. ncbi Cortical and putamen age-related changes in the microvessel density and astrocyte deficiency in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats
    Marie Françoise Ritz
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Curr Neurovasc Res 6:279-87. 2009
    ..SP-SHR) as a models for SVD, we analysed the effect of hypertension on the microvasculature in the cortex and putamen, and on its relationship with astrocytes in animals aged 2 to 9 months...
  72. ncbi Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    By using diffusion-weighted imaging (DWI), we have recently shown abnormal diffusivity in the putamen of patients with the Parkinson variant of multiple system atrophy (MSA-P) which also correlated with disease severity, indicating the ..
  73. ncbi Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus
    J J Rodriguez
    Department of Neurology and Neuroscience, Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 21:823-33. 2001
    ..subtype 1 receptor (CB1R) and the mu-opioid receptor (muOR), in the striatal circuitry originating in the caudate putamen nucleus (CPN). Thus, the CB1R and muOR may show similar targeting in the CPN...
  74. ncbi Transcriptional changes in multiple system atrophy and Parkinson's disease putamen
    Ina R Vogt
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Exp Neurol 199:465-78. 2006
    ..in MSA, we chose CNS regions differentially affected in MSA and PD for comparative gene expression profiling: putamen, cerebellum and occipital cortex...
  75. ncbi Neuronal encoding of reward value and direction of actions in the primate putamen
    Yukiko Hori
    Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Neurophysiol 102:3530-43. 2009
    ..To address this issue, we investigated the activities of presumed projection neurons in the putamen of macaque monkeys performing a visually instructed GO-NOGO button-press task for large and small rewards...
  76. ncbi Dopamine precursor depletion impairs timing in healthy volunteers by attenuating activity in putamen and supplementary motor area
    Jennifer T Coull
    Laboratoire des Neurosciences Cognitives, Aix Marseille University and CNRS, 13331 Marseille Cedex 3, France
    J Neurosci 32:16704-15. 2012
    ..Neurally, APTD attenuated timing-specific activity in the putamen and SMA...
  77. ncbi Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case study
    Taresa Stefurak
    Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 18:1508-16. 2003
    ..DBS primarily showed changes in motor regions: increases in premotor and motor cortex, ventrolateral thalamus, putamen, and cerebellum as well as decreases in sensorimotor/supplementary motor cortex...
  78. ncbi Up-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvement
    Christophe Bossuet
    Service de Neurovirologie, UMR E1 CEA, Universite Paris Sud, Centre de Recherches du Service de Sante des Armees, Ecole Pratique des Hautes Etudes, Institut Paris Sud Cytokines, Fontenay aux Roses, France
    J Neurochem 88:928-38. 2004
    We quantified putamen and prefrontal cortex metabolites in macaques with simian immunodeficiency virus infection and searched for virological and histological correlates...
  79. pmc Reinforcement mechanisms in putamen during high frequency STN DBS: A point process study
    Sabato Santaniello
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:1214-7. 2012
    Despite a pivotal role in the motor loop, dorsolateral striatum (putamen) has been poorly studied thus far under Parkinsonian conditions and Deep Brain Stimulation (DBS)...
  80. ncbi Induced spreading depression activates persistent neurogenesis in the subventricular zone, generating cells with markers for divided and early committed neurons in the caudate putamen and cortex
    Hiroji Yanamoto
    Laboratory for Cerebrovascular Disorders, Research Institute of National Cardiovascular Center, Japan
    Stroke 36:1544-50. 2005
    ..We determined whether spreading depression, a common epiphenomenon of these conditions, stimulates persistent neurogenesis...
  81. pmc Global and regional putamen volume loss in patients with heart failure
    Rajesh Kumar
    Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, 90095 1763, USA
    Eur J Heart Fail 13:651-5. 2011
    ..A basal ganglia structure, the putamen, serves many functions that are affected in HF, but its global or localized structural integrity is unknown...
  82. pmc A multivariate surface-based analysis of the putamen in premature newborns: regional differences within the ventral striatum
    Jie Shi
    School of Computing, Informatics, Decision Systems and Engineering, Arizona State University, Tempe, Arizona, United States of America
    PLoS ONE 8:e66736. 2013
    ..We performed regional group comparisons of the surface anatomy of the striatum (putamen and globus pallidus) between 17 preterm and 19 term-born neonates at term-equivalent age...
  83. ncbi Decreased brainstem and putamen SERT binding potential in depressed suicide attempters using [11C]-zient PET imaging
    Jonathon A Nye
    Departments of Radiology, Emory University School of Medicine, Atlanta, Georgia
    Depress Anxiety 30:902-7. 2013
    ....
  84. pmc The role of the basal ganglia and cerebellum in language processing
    James R Booth
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA
    Brain Res 1133:136-44. 2007
    ..has reciprocal connections with both left inferior frontal gyrus and left lateral temporal cortex, whereas the putamen has unidirectional connections into these two brain regions...
  85. pmc GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen
    Kalynda Kari Gonzales
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 521:2502-22. 2013
    ..ultrastructural analysis of the GABAergic and glutamatergic innervation of ChIs in the postcommissural putamen of rhesus monkeys...
  86. pmc Clinical and magnetic resonance imaging study of extrapyramidal symptoms in multiple system atrophy
    M Konagaya
    Department of Neurology, Suzuka National Hospital, Japan
    J Neurol Neurosurg Psychiatry 57:1528-31. 1994
    Slit-hyperintensity in the outer margin of the putamen on T2 weighted MRI was found in 17 out of 28 patients with clinically diagnosed multiple system atrophy. Thirteen of these 17 patients showed extrapyramidal signs...
  87. ncbi Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
    M Li
    The Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Psychol Med 42:1475-83. 2012
    ..In this study, the authors explore this relationship...
  88. ncbi Loss of asymmetry in D2 receptors of putamen in unaffected family members at increased genetic risk for schizophrenia
    K J Lee
    Neuroscience Institute, Seoul National University Medical Research Center, Seoul, South Korea
    Acta Psychiatr Scand 118:200-8. 2008
    ..The present study was performed to examine whether unaffected relatives at high genetic risk of schizophrenia have dopamine dysregulation in comparison with healthy controls...
  89. ncbi Event-related desynchronization/synchronization in the putamen. An SEEG case study
    D Sochurkova
    First Department of Neurology, St Anne s Hospital, Masaryk University, Brno, Czech Republic
    Exp Brain Res 149:401-4. 2003
    ..An electrode that was targeted in the amygdalo-hippocampal complex passed through the putamen with several contacts...
  90. ncbi High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice
    Timothy South
    Neurobiology Research Centre for Metabolic and Psychiatric Disorders, School of Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Neurochem Res 33:598-605. 2008
    ..increased D2 receptor and decreased DAT density in the dorsal and ventral parts of the caudal caudate putamen (D2: 32% and 35% respectively, DAT: 33.3% and 28.8% respectively) compared with low-fat diet...
  91. ncbi Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neurotrophic factor in nestin-expressing reactive astrocytes in the caudate-putamen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/Bl mice
    Liang Wei Chen
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, People s Republic of China
    J Comp Neurol 497:898-909. 2006
    ..B staining, and this was accompanied by an increase in nestin-expressing astrocytes within the caudate-putamen. The number of nestin-positive reactive astrocytes in the caudate-putamen peaked within 3-5 days following MPTP ..
  92. ncbi Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study
    D A Cousins
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 61:1191-5. 2003
    To compare the volume of the putamen on MRI in subjects with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) and age-matched normal control subjects, along with the relationship between putamen volume and severity of both ..
  93. ncbi T2*-weighted MRI in diagnosis of multiple system atrophy. A practical approach for clinicians
    Friederike von Lewinski
    Paracelsus Elena Klinik, Klinikstr 16, 34128 Kassel, Germany
    J Neurol 254:1184-8. 2007
    ..T2*-weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore may support the clinical differential diagnosis between MSA and PD...
  94. ncbi An fMRI motor activation paradigm demonstrates abnormalities of putamen activation in females with panic disorder
    William R Marchand
    Department of Veterans Affairs VISN 19 MIRECC, Salt Lake City, Utah 84148, USA
    J Affect Disord 116:121-5. 2009
    The neurobiology of panic disorder is incompletely understood. The aim of this study was to determine if functional abnormalities of the putamen occur in panic disorder.
  95. ncbi Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice
    Stefan D Schlussman
    The Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 974:249-53. 2003
    Preprodynorphin mRNA was measured in the nucleus accumbens (NAc) and caudate putamen (CPu) after 3-day 'binge' pattern cocaine administration in C57BL/6J and 129/J mice, strains which differ in behavior and in dopamine increases in the ..
  96. ncbi Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  97. ncbi Effect of chronic "binge cocaine" on basal levels and cocaine-induced increases of dopamine in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice
    Yong Zhang
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 50:191-9. 2003
    ..of chronic "binge" pattern cocaine administration on basal and cocaine-induced dopamine levels in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice...
  98. ncbi Modulation of neuronal activity in the monkey putamen associated with changes in the habitual order of sequential movements
    Marc Deffains
    Laboratoire de Neurobiologie de la Cognition, Université de Provence Centre National de la Recherche Scientifque, Marseille, France
    J Neurophysiol 104:1355-69. 2010
    ..We recorded single neurons in the posterior putamen of two monkeys performing an overlearned sequence of arm reaching movements to examine whether task-related ..
  99. ncbi Field strengths and sequences influence putaminal MRI findings in multiple system atrophy
    H Watanabe
    Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    Neurology 62:671. 2004
  100. ncbi Behavioral effects of somatostatin microinjected into caudate putamen
    R Tashev
    Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Neuropeptides 35:271-5. 2001
    ..present study examined the behavioral responses to bilateral microinjections of somatostatin (SRIF) into caudate putamen of male Wistar rats...
  101. pmc Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
    Functional neuroimaging and lesion studies have frequently reported thalamic and putamen activation during reading and speech production...

Research Grants64

  1. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..of these patients have consistently revealed lesions in the basal ganglia, including the globus pallidus and putamen. Damage in the human brain has been confirmed via autopsy...
  2. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..the striatum-nigro-thalamic-cortical and pedunculopontine pathway system, and compare neuropathology of caudate, putamen, globus pallidus, thalamus substantia nigra and brainstem especially superior coliculus and dorsal pons varolii ..
  3. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..samples from different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, amygdala and fronto-cortical regions (cingulate and subgenual cortical areas)..
  4. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..inhibition by CB1 and D2 receptors in subregions of the striatum/BG in Gng7 knockout mice, including caudate-putamen, nucleus accumbens and globus pallidus, as well as other CB1 and D2 containing regions such as prefrontal cortex ..
  5. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..response of this network to tastes of sucrose is diminished in REC AN and is negatively associated with ventral putamen [11C]raclopride BP...
  6. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..ganglia glucose metabolism and increased uptake of the DA precursor, [18F]fluorodopa (FDOPA), in caudate and putamen. To further characterize these IFN-alpha effects on DA pathways, we have recently developed an animal model of ..
  7. Diet, Insulin, Dopamine, and Reward.
    Margaret E Rice; Fiscal Year: 2013
    ..show that nM levels of insulin increase evoked extracellular dopamine (DA) concentration ([DA]o) in caudate/putamen (CPu) and nucleus accumbens (NAc). Notably, this response is enhanced in FR rats, but blunted in OB rats...
  8. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
    ..In particular, brain regions like the nucleus accumbens (NAC) and caudate-putamen (CPU) that contribute to the reward and motivational properties of THC have reduced sensitivity to ..
  9. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2011
    ..Increased uptake and decreased release of the DA precursor, [18F]fluorodopa, in the caudate and putamen of IFN-alpha-treated patients has also been observed...
  10. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..Important components of this circuitry include the caudate-putamen, nucleus accumbens, central nucleus of the amygdala, and the ventral tegmental area (VTA)...
  11. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013
    ..The major component of the basal ganglia, the striatum (or caudate-putamen) processes cortical inputs and subsequently regulates the output nuclei of the basal ganglia through two output ..
  12. Roles of Gsh1 &Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2012
    ..One of the major telencephalic structures controlling these processes is the striatum (also known as the caudate-putamen)...
  13. Oxytocin Receptors and Social Behavior
    Larry J Young; Fiscal Year: 2013
    ..g. NAcc and caudate putamen) is associated with variation in social behavior in male and female prairie voles at multiple developmental ..
  14. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin H Teicher; Fiscal Year: 2010
    ..0). The second marker is a measure of regional T2-relaxation time (T2RT) in left putamen and right dorsolateral prefrontal cortex...
  15. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..in several brain regions, with the greatest reductions in the pallidum >anterior cingulate cortex >putamen >hippocampus >amygdala...
  16. Molecular Mechanisms of Nicotine Addiction and Extinction
    Noboru Hiroi; Fiscal Year: 2011
    ..studies show that a) nicotine elevates the concentration of cGMP in the striatum (nucleus accumbens and caudate-putamen), b) nicotine can up-regulate PKG activity in the nucleus accumbens and the VTA, which represent a target and the ..
  17. Regional Brain Manganese Accumulation and Functional Consequences in Welders
    Xuemei Huang; Fiscal Year: 2013
    ..g., olfactory bulbs (OB), basal ganglia (BG: i.e., caudate, putamen &GP), frontal lobe (FL: i.e...
  18. Progressive dopamine loss:effect of exercise on striatal and nigral glutamate
    CHARLES KENNETH MESHUL; Fiscal Year: 2013
    ..partial loss of at least the dopamine (DA) input from the substantia nigra pars compacta (SNpc) to the caudate/putamen (CPu). This also alters the glutamate input to the CPu and substantia nigra (SN)...
  19. Decision Support System for Temporal Lobe Epilepsy
    Hamid Soltanian-Zadeh; Fiscal Year: 2013
    ..and feature extraction methods will segment and characterize hippocampus, amygdala, entorhinal cortex, thalamus, putamen, and other brain structures from MRI...
  20. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  21. Basal Ganglia Functions in Huntington's Disease: Genetic Mouse Models
    Elizabeth D Abercrombie; Fiscal Year: 2012
    ..of the brain are the cerebral cortex and the subcortical nuclei of the basal ganglia, in particular the caudate/putamen. There currently is no satisfactory therapy for the disease and the hope for a cure remains distant despite the ..
  22. Striatal Dopamine Release in Response to Ultraviolet Light in Compulsive Tanners
    BRYON H ADINOFF; Fiscal Year: 2013
    ..decrease in Desire to Tan and a relative increase in rCBF of the dorsal striatum (including caudate and putamen), anterior insula, and medial orbitofrontal cortex...
  23. Electrophysiological mechanisms of HIV-mediated neuropathogenesis
    Xiu Ti Hu; Fiscal Year: 2013
    ..alters two key regulators of cognition and psychomotor activity, the medial prefrontal cortex (mPFC) and caudate-putamen (CPu;a.k.a. dorsal striatum)...
  24. Ontogeny of caudate-putamen functioning: behavioral relevance
    SANDERS MCDOUGALL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The caudate-putamen (CPu) is the major input and processing component of the basal ganglia...
  25. Long-term consequences of methamphetamine toxicity
    Kristen A Keefe; Fiscal Year: 2012
    ..that methamphetamine (METH) abuse leads to long-lasting decreases in the dopamine innervation of the caudate-putamen in humans, as well as other species...
  26. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
    ..from bone marrow, referred to as mesenchymal stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  27. Anatomical and Physiological Characterization of the Thalamostriatal System
    KALYNDA GONZALES; Fiscal Year: 2012
    ..to the striatum in regulating the spontaneous and CM-stimulation induced neuronal activity in TANs in the primate putamen and (2) To define the microcircuitry and chemical phenotype of GABAergic synaptic inputs along the ..
  28. MODERATE LEVEL PRENATAL ALCOHOL EXPOSURE IN PRIMATES
    Mary L Schneider; Fiscal Year: 2010
    ..Specific Aims 2 will assess the binding of D2 receptors in the prefrontal cortex, caudate, putamen, and ventral striatum, and assess performance on an executive function test that is dependent on these regions...
  29. BDNF, Dopamine and Ethanol
    TIFFANY ANNE MATHEWS; Fiscal Year: 2010
    ..abuse;like ethanol, have the ability to elevate extracellular dopamine levels in brain areas such as the caudate-putamen and nucleus accumbens...
  30. Behavioral Characterization of Acute and Chronic Amphetamine
    Ronald Kuczenski; Fiscal Year: 2012
    ..profile, the methamphetamine-induced extracellular dopamine response will be significantly reduced in the caudate-putamen, whereas the dopamine response will be relatively unchanged or augmented in specific mesolimbic-cortical regions, ..
  31. Reduced vesicular catecholamine storage mediates oxidant-induced neurotoxicity
    TONYA NICOLE TAYLOR; Fiscal Year: 2010
    ..PD) is a debilitating neurodegenerative disorder, which is characterized by the loss of dopamine (DA) in the putamen and DA producing neurons of the substantia nigra, resulting in motor disturbances such as tremor, rigidity, ..
  32. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
    ..g. ventral pallidum, ventral striatum, anterior cingulate) and dorsal STN to motor systems in the brain (e.g. putamen, primary motor cortex)...
  33. High-resolution DT-MRI for differentiation of malignant glioma from radiation nec
    Jinyuan Zhou; Fiscal Year: 2010
    ..patterns associated with histologically confirmed radiation-induced necrosis after focal radiation to the caudate-putamen in healthy rats. (3) To assess the ability of high-resolution DTI at 4...
  34. The role of dopamine mechanisms in the development of addiction to cocaine
    EVGENY ALEXANDER BUDYGIN; Fiscal Year: 2010
    ..2. What changes occur in DA receptor and DA transporter levels in the ventral tegmental area, caudate putamen and nucleus accumbens following cocaine self-administration. 3...
  35. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..received cultured mesencephalic tissue from four embryos along four 30 to 40 mm needle tracts bilaterally in the putamen. Control patients had burr holes but no actual implantations. No patients were immunosuppressed...
  36. Striatal mechanisms of relapse to cocaine seeking
    Carmela M Reichel; Fiscal Year: 2012
    ..These findings have implicated a significant role of the dorsolateral caudate-putamen (dlCPu) in mediating relapse following abstinence...
  37. nNOS-containing striatal interneurons and methamphetamine-induced neurotoxicity
    ASHLEY NICOLE FRICKS-GLEASON; Fiscal Year: 2013
    ..now established that METH abuse leads to long-lasting decreases in the dopamine (DA) innervation of the caudate-putamen in humans, as well as other species...
  38. Arc, phasic dopamine, and methamphetamine-induced striatal learning deficits
    ELISSA DAINES PASTUZYN; Fiscal Year: 2013
    ..5 million use the drug regularly. METH is known to cause partial dopamine depletion in the caudate/putamen (striatum) in humans, and these depletions cause long-term deficits in the cognitive functions of METH abusers...
  39. Combined Multi-Pinhole and Fan-Beam Brain SPECT
    Michael A King; Fiscal Year: 2013
    ..perfusion imaging where the entire brain is the volume of interest, with PD the structures of interest are the putamen and caudate (and potentially substantia nigra) which lie in the interior portion of the brain...
  40. Basal Ganglia Shape Analysis and Circuitry in Huntington's Disease
    Christopher A Ross; Fiscal Year: 2013
    ..Specifically Aim 1 will perform cross- sectional statistical shape analysis (caudate, putamen, thalamus, hippocampus, nucleus accumbens and globus pallidus) in 351 subjects with and without prodromal HD;Aim ..
  41. PET RADIOTRACERS FOR IMAGING THE DOPAMINE D3 RECEPTOR
    Robert H Mach; Fiscal Year: 2013
    ..there is a 45% reduction in D3 receptors in the ventral striatum and a 15% increase in D2 receptors the caudate/putamen of postmortem brain samples of Parkinson's Disease...
  42. Acute Brain Response to Alcohol: an fMRI Study
    Emma Childs; Fiscal Year: 2011
    ..that alcohol will produce dose-related signal changes in the nucleus accumbens, ventral tegmentum, caudate, putamen, amygdala, anterior cingulate, prefrontal cortex and cerebellum...
  43. Pathophysiology of Auditory Hallucinations
    RALPH EDWARD HOFFMAN; Fiscal Year: 2013
    ..loop linking sites in Wernicke's area, a right homologue of Wernicke's area, left IFG, and the putamen. Hallucinators with schizophrenia demonstrated robustly greater FC summed across this corticostriatal loop ..
  44. Focal Dopamine Indicated in Dyskinesias in MPTP Monkeys
    Krystof S Bankiewicz; Fiscal Year: 2010
    ..activity (hotspots) are created within the most severely affected part of the striatum, the post-commissural putamen. Transduced with an AAV containing the cDNA for aromatic L- amino acid decarboxylase (AADC), striatal neurons ..
  45. THE GENETICS OF PARKINSONISM
    Jeffery Marvin Vance; Fiscal Year: 2010
    ..and extends our expression studies of tissue obtained by our autopsy program by adding examination of the putamen and the anterior olfactory nucleus to the SN, as well as using Laser Capture Microscope to investigate specific ..
  46. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..In the developing caudate-putamen (neostriatum), these boundaries surround different compartments of a neostriatal mosaic, the patch and matrix, ..
  47. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2009
    ..can deliver GDNF chronically in the freely-moving MPTP-lesioned monkey to evaluate multisite delivery of GDNF (putamen vs. putamen + substantia nigra) to improve the functional restoration of DA systems...
  48. NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 2001
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  49. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2009
    ..of conditioned fear whereas infusion of comparable doses into the central (Ce), basolateral (Bla) or caudate-putamen had no effect...
  50. STREP, HOST FACTORS, AUTOANTIBODIES & TOURETTE SYNDROME
    Harvey Singer; Fiscal Year: 2000
    ..support of an immune-related hypothesis for TS, our preliminary studies showed that a) serum antibodies to human putamen, but not to caudate or globus pallidus, are significantly increased in children with TS and b) after ..
  51. MOTOR FUNCTIONS AND FIBER CONNECTIONS OF PALLIDUM
    SAMUEL LILES; Fiscal Year: 1990
    ..experiments are designed to provide new information on the integrative functions of neurons in the pallidum and putamen. Since the putamen has been shown by both anatomical and physiological methods to contain somatotopically ..
  52. CHARACTERIZATION OF A NEURON-SPECIFIC PHOSPHOPROTEIN
    Samuel Gandy; Fiscal Year: 1990
    ..which include Huntington's disease (caudate), Parkinson's disease (substantia nigra), and the dystonias (putamen and globus pallidus)...
  53. Neostriatal Visual Processing & Initiation of Movement
    Emad Eskandar; Fiscal Year: 2005
    ..The input nuclei of the basal ganglia in primates include the caudate and putamen. The output nuclei include the Gpi and the substantia nigra pars reticulata...
  54. THE CONNECTIONAL ORGANIZATION OF THE THALAMUS
    JOHN HARTING; Fiscal Year: 2001
    The centromedian nucleus (CM-Pf) projects to striatal (caudate and putamen) neurons that are key components of basal ganglia pathways that regulate movement...
  55. HIGH FIELD MRI IN PARKINSONS DISEASE
    Jay Gorell; Fiscal Year: 1999
    ..However, the clinical significance of iron accumulation in SN, or elsewhere in basal ganglia (e.g., putamen [PUT] or globus pallidus [GP] in PD, has not been defined in living human subjects...
  56. FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
    WARREN MECK; Fiscal Year: 2000
    ..The input of the basal ganglia (that is the caudate and putamen) receive substantial projections from diverse regions of the cerebral cortex including motor, sensory, prefrontal,..
  57. Transitioning Microfabricated Multiple Electrode Arrays to Freely Moving Animal R
    Gregory S McCarty; Fiscal Year: 2012
    ..This project will improve the state-of-the-art to enable monitoring dopamine release in the caudate putamen of awake and behaving animals...
  58. POSITRON EMISSION TOMOGRAPHY INVESTIGATIONS OF DYSTONIA
    Joel Perlmutter; Fiscal Year: 1999
    ..We now have evidence that there is an abnormality of [18F]spiperone ([18F]SP) binding in the putamen, one of the key basal ganglia nuclei involved in motor control...
  59. ANTI-INFLAMMATORY THERAPIES NEUROTOXICALLY INDUCED PD
    Ole Isacson; Fiscal Year: 2004
    ..al. JAMA, 1999). Interestingly, neuroinflammation seen in the caudate-putamen is a part of the pathophysiology (Brooks, 1999)...
  60. ENCAPSULATED DOPAMINERGIC TUMOR CELLS AS BRAIN IMPLANTS
    CHRISTINE JAEGER; Fiscal Year: 1991
    ..The encapsulated cells will be either further maintained in culture or placed into the caudate-putamen or globus pallidus regions of Sprague Dawley rats...
  61. The Role of Omega-3 Fatty Acids in Adolescent Depression
    Vilma Gabbay; Fiscal Year: 2010
    ..MDD, 1) Compared to placebo, omega-3FA will lead to significantly lower concentrations of striatal (caudate and putamen) and anterior cingulate cortex (ACC) tCho, tCr, and greater GABA concentrations in the ACC;2) improvement with ..
  62. CEREBRAL MITOCHONDRIAL METABOLISM IN NEURODEGENERATION
    William Powers; Fiscal Year: 2004
    ..to pathologic insult have larger magnitude or selective defects in cerebral mitochodrial metabolism - caudate and putamen in HD and substantia nigra and putamen in PD...
  63. Levodopa dyskinesia and striatal neuroplasticity
    Christine Konradi; Fiscal Year: 2007
    ..disease, and L-DOPA-induced dyskinesia, are accompanied by unique patterns of gene expression in the putamen. By comparing the gene expression patterns of dyskinesia to non-dyskinesia, we may find the critical factors ..
  64. NORMAL METABOLISM AND ANATOMY OF BASAL FOREBRAIN IN MAN
    Monte Buchsbaum; Fiscal Year: 2000
    ..innominata) and ventral pallidum because they have been less studied (relative to the dorsal caudate and putamen) with MRI in man...