putamen

Summary

Summary: The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus.

Top Publications

  1. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
  2. ncbi Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD
    M F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neurology 58:575-80. 2002
  3. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
  4. ncbi Representation of action-specific reward values in the striatum
    Kazuyuki Samejima
    Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619 0288 Kyoto, Japan
    Science 310:1337-40. 2005
  5. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
  6. pmc Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates
    Dali Yin
    Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, MCB 226, San Francisco, CA 94103, USA
    Neuroimage 54:S196-203. 2011
  7. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
  8. pmc Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates
    Verginia C Cuzon Carlson
    Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
    Neuropsychopharmacology 36:2513-28. 2011
  9. ncbi Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
  10. doi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008

Detail Information

Publications244 found, 100 shown here

  1. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
    ..Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor...
  2. ncbi Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD
    M F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neurology 58:575-80. 2002
    ..However, it is currently unknown whether diffusion-weighted imaging (DWI) discriminates these disorders...
  3. ncbi Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Brain 131:120-31. 2008
    ..has focussed recently on the possibility that the remaining serotonin neurons innervating striatum (caudate and putamen) might release dopamine as a 'false transmitter'--an action that could have both beneficial and harmful (e.g...
  4. ncbi Representation of action-specific reward values in the striatum
    Kazuyuki Samejima
    Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619 0288 Kyoto, Japan
    Science 310:1337-40. 2005
    ..Fewer neurons were tuned to relative values or action choice. These results suggest representation of action values in the striatum, which can guide action selection in the basal ganglia circuit...
  5. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..It was hypothesized that putamen D(2) binding potential would be higher during major depressive episodes featuring motor retardation.
  6. pmc Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates
    Dali Yin
    Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, MCB 226, San Francisco, CA 94103, USA
    Neuroimage 54:S196-203. 2011
    ..we retrospectively analyzed MRI of 25 convection-enhanced delivery (CED) infusions with MRI contrast into the putamen of non-human primates (NHP)...
  7. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
    ..Analysis revealed that the putamen, the pulvinar and, to a smaller degree, the caudate nucleus are the subcortical structures typically associated ..
  8. pmc Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates
    Verginia C Cuzon Carlson
    Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
    Neuropsychopharmacology 36:2513-28. 2011
    ..protocol, we found a selective increase in dendritic spine density and enhanced glutamatergic transmission in the putamen, but not in the caudate nucleus...
  9. ncbi Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
    To analyze the organization of corticostriatal motor inputs, we examined the neuronal responses in the putamen (Put) to stimulation in the primary motor cortex (MI) and the supplementary motor area (SMA)...
  10. doi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008
    ..This approach holds promise for studying basal ganglia dysfunction in clinical disorders...
  11. ncbi Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing
    B Jill Venton
    Department of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    J Neurochem 87:1284-95. 2003
    ..These simulations show that synchronous phasic firing can produce spatially and temporally heterogeneous concentration profiles whereas asynchronous tonic firing elicits uniform, steady-state dopamine concentrations...
  12. pmc Differential recruitment of the sensorimotor putamen and frontoparietal cortex during motor chunking in humans
    Nicholas F Wymbs
    Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106, USA
    Neuron 74:936-46. 2012
    ..Activity in the bilateral sensorimotor putamen positively correlated with chunk concatenation, whereas a left-hemisphere frontoparietal network was correlated ..
  13. ncbi Convective delivery of glial cell line-derived neurotrophic factor in the human putamen
    Paul F Morrison
    Division of Bioengineering and Physical Science, Office of Research Services, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 107:74-83. 2007
    ..The authors conducted an analysis of the distribution of glial cell line-derived neurotrophic factor in the human striatum following convection-enhanced delivery...
  14. ncbi Mu-opioid and NMDA-type glutamate receptors are often colocalized in spiny neurons within patches of the caudate-putamen nucleus
    H Wang
    Division of Neurobiology, Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 412:132-46. 1999
    The patch compartments of the caudate-putamen nucleus (CPN) are enriched in mu-opioid receptors (MORs) and have been recently implicated in reward-related behaviors...
  15. pmc The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions
    Christopher J Starr
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Brain 134:1987-2004. 2011
    ..These interactions occur via cortico-basal ganglia-thalamo-cortical loops. The putamen is one of the major sites of cortical input into basal ganglia loops and is frequently activated during pain...
  16. pmc Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices
    Carrie E John
    Wake Forest University School of Medicine, Department of Physiology and Pharmacology, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuropharmacology 52:1596-605. 2007
    ..and fenfluramine on dopamine and serotonin uptake following electrically stimulated release in mouse caudate-putamen and substantia nigra pars reticulata slices...
  17. doi Differential roles of caudate nucleus and putamen during instrumental learning
    Andrea Brovelli
    Institut de Neurosciences Cognitives de la Mediterranee, UMR 6193, CNRS and Université Aix Marseille II, Marseille, France
    Neuroimage 57:1580-90. 2011
    ..The anterior caudate nucleus integrates information about performance and cognitive control demands, whereas the putamen tracks how likely the conditioning stimuli lead to correct response...
  18. ncbi Impairment of motor imagery in putamen lesions in humans
    C R Li
    Medical Research Center and Department of Psychiatry, Chang Gung Memorial Hospital, 5 Fu Hsing Street, Kwei Shan, 333, Tao Yuan, Taiwan
    Neurosci Lett 287:13-6. 2000
    Patients with putamen or cortical lesions participated in a first- and third-person movement imagery task, each primarily engaging kinesthetic and visual imagery...
  19. pmc Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings
    Ethan R Buch
    Section on Neurophysiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institute of Health, 49 Convent Drive, MSC 4401, Building 49 Room B1EE17, Bethesda, MD 20892 4401, USA
    Exp Brain Res 169:69-84. 2006
    ..activity patterns evolved at approximately the same time in both the dorsal premotor cortex (PMd) and the putamen. Here we report that, in both regions, the population activity for novel mappings came to resemble that for ..
  20. ncbi Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation
    X T Hu
    Neuropsychopharmacology Laboratory, Wayne State University School of Medicine, Lafayette Clinic, Detroit, Michigan 48207
    J Neurosci 10:2318-29. 1990
    ..were used to determine the sensitivities and interactions of D1 and D2 dopamine (DA) receptors in the caudate putamen (CPu) of rats that were denervated of DA by intraventricular injections of the catecholamine neurotoxin 6-..
  21. pmc Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning
    M G Packard
    Department of Psychology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 96:12881-6. 1999
    ..was used to examine the hypothesis that posttraining neurochemical manipulation of the hippocampus or caudate-putamen can bias an animal toward the use of a specific memory system...
  22. ncbi Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006
    ..In the striatum, two distinct sets of the labeling were observed: one in the dorsal putamen, and the other in the ventral striatum (ventromedial putamen and nucleus accumbens)...
  23. ncbi Somatotopic representation of nociceptive information in the putamen: an event-related fMRI study
    U Bingel
    NeuroImage Nord, Department of Neurology, Hamburg University Medical School, Germany
    Cereb Cortex 14:1340-5. 2004
    ..functional magnetic resonance imaging (fMRI) to assess whether nociceptive information is represented in the putamen in a somatotopic manner...
  24. pmc Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice
    Ilka Freiman
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, D 79104 Freiburg i Br, Germany
    J Physiol 575:789-806. 2006
    CB(1) cannabinoid receptors are expressed in many neurons in the caudate-putamen. However, it is not known how the activation of these receptors influences synaptic transmission between different neuron classes...
  25. pmc Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study
    L W de Jong
    Department of Radiology, University Medical Center, Leiden, The Netherlands
    Brain 131:3277-85. 2008
    ..Using 3T 3D T1 MR images, volumes of nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen and thalamus were automatically calculated by the FMRIB's Integrated Registration and Segmentation Tool (FIRST)--..
  26. ncbi fMRI reveals two distinct cerebral networks subserving speech motor control
    A Riecker
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Neurology 64:700-6. 2005
    ..The authors used fMRI to further examine the neural basis of speech motor control...
  27. ncbi Onset and rate of striatal atrophy in preclinical Huntington disease
    E H Aylward
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neurology 63:66-72. 2004
    ..Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms...
  28. pmc Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
    James R Connor
    Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Brain 132:2403-12. 2009
    ..In this study, the substantia nigra and putamen were obtained at autopsy from individuals with primary RLS and a neurologically normal control group...
  29. pmc Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
    Rita A Fuchs
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3584-8. 2006
    ..We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence...
  30. ncbi Foot, hand, face and eye representation in the human striatum
    Emmanuel Gerardin
    Service Hospitalier Frederic Joliot, Department of Medical Research, CEA, Orsay, France
    Cereb Cortex 13:162-9. 2003
    ..For foot, hand and face movements, striatal activation was mainly found in the putamen with a somatotopical organization, the foot area being dorsal, the face area more ventral and medial, the hand ..
  31. doi Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens
    Devadoss J Samuvel
    Division of Neuroscience Research, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 325:293-301. 2008
    ..Using ex vivo caudate putamen (CPu) and nucleus accumbens (NAcc) synaptosomal preparations, we found that DA uptake was significantly higher in ..
  32. doi Specific neuromodulatory actions of amyloid-beta on dopamine release in rat nucleus accumbens and caudate putamen
    Elisa Mura
    Department of Experimental and Applied Pharmacology, University of Pavia, Pavia, Italy
    J Alzheimers Dis 19:1041-53. 2010
    ..Abeta (1-40) on DA transmission to different release stimuli and to another dopaminergic brain area, the caudate putamen (CPu), in order to clarify whether the effect of the peptide is stimulus- or brain area-selective...
  33. doi Increased xanthine oxidase in the thalamus and putamen in depression
    Tanja Maria Michel
    Neurochemistry Laboratory, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 11:314-20. 2010
    ..We measured the XO activity in following brain areas: hippocampus, regio entorhinalis, thalamus, putamen and caudate nucleus...
  34. ncbi Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ..alters the metabolic ratios NAA/Cho, NAA/Cr, Cho/Cr and Ins/Cr in the left dorsolateral prefrontal cortex, anterior cingulate cortex, and putamen in healthy subjects and psychiatric patients irrespective of clinical diagnosis.
  35. ncbi Event-related desynchronization/synchronization in the putamen. An SEEG case study
    D Sochurkova
    First Department of Neurology, St Anne s Hospital, Masaryk University, Brno, Czech Republic
    Exp Brain Res 149:401-4. 2003
    ..An electrode that was targeted in the amygdalo-hippocampal complex passed through the putamen with several contacts...
  36. pmc Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy
    Mizuki Ito
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 78:722-8. 2007
    ....
  37. doi Functional neural correlates of psychometric schizotypy: an fMRI study of antisaccades
    Désirée S Aichert
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Psychophysiology 49:345-56. 2012
    ..reduced blood oxygenation level dependent signal and higher schizotypy were found during antisaccades in the putamen, thalamus, cerebellum, and visual cortex and during prosaccades in the visual cortex, supplementary eye field, ..
  38. pmc Clinical and magnetic resonance imaging study of extrapyramidal symptoms in multiple system atrophy
    M Konagaya
    Department of Neurology, Suzuka National Hospital, Japan
    J Neurol Neurosurg Psychiatry 57:1528-31. 1994
    Slit-hyperintensity in the outer margin of the putamen on T2 weighted MRI was found in 17 out of 28 patients with clinically diagnosed multiple system atrophy. Thirteen of these 17 patients showed extrapyramidal signs...
  39. ncbi Hyperintense putaminal rim sign is not a hallmark of multiple system atrophy at 3T
    Wei Hsing Lee
    Department of Radiology, Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, Republic of China
    AJNR Am J Neuroradiol 26:2238-42. 2005
    ..We hypothesized that the HPR sign is not an exclusive hallmark of MSA at a high magnetic field strength, but rather may be a normal finding...
  40. pmc [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen
    Jinbin Xu
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Synapse 64:449-59. 2010
    ..A mathematical model for calculating the absolute densities of dopamine D(2) and D(3) receptors based on the in vitro receptor binding data of [3H]WC-10 and [3H]raclopride was developed...
  41. ncbi Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: a resting-state functional magnetic resonance imaging study
    Bo Zhou
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Mov Disord 25:1226-31. 2010
    ..The whole brain analysis indicated that the patient group had significantly increased ALFF in the bilateral putamen (P < 0.005) than normal control. fMRI could be useful to evaluate PKC with negative conventional imaging...
  42. doi Effect of acute and continuous morphine treatment on transcription factor expression in subregions of the rat caudate putamen. Marked modulation by D4 receptor activation
    Belen Gago
    Department of Cell Biology, School of Science, University of Malaga, 29071 Malaga, Spain
    Brain Res 1407:47-61. 2011
    ..induces a down-regulation of the μ opioid receptor (MOR) in the striosomal compartment of the rat caudate putamen (CPu), suggesting a striosomal D(4)R/MOR receptor interaction in line with their high co-distribution in this ..
  43. ncbi Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: relation to estimated iron and water contents
    N Gelman
    Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, Michigan 48202, USA
    Magn Reson Med 45:71-9. 2001
    ..567 +/- 0.020 sec(-1)), caudate head (0.675 +/- 0.019 sec(-1)), putamen (0.749 +/- 0.023 sec(-1)), substantia nigra (0.873 +/- 0.037 sec(-1)), globus pallidus (0.960 +/- 0...
  44. pmc AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters
    Laura M Sanftner
    Avigen Inc, 1301 Harbor Bay Parkway, Alameda, CA 94502, USA
    Exp Neurol 194:476-83. 2005
    ..AAV2 encoding the human aromatic l-amino acid decarboxylase gene (AAV-hAADC-2) was infused into the putamen of 4 normal rhesus monkeys as a supportive study for a clinical trial in Parkinson's disease (PD) patients...
  45. ncbi Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias
    Frederic Calon
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec, Canada
    J Neuropathol Exp Neurol 61:186-96. 2002
    ..A significant increase of preproenkephalin messenger RNA levels was observed in the lateral putamen of dyskinetic patients in comparison to controls (+210%; p < 0...
  46. ncbi Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Harvard Medical School Belmont 02178, USA
    Neurosci Lett 254:21-4. 1998
    Density of dopamine transporter (DAT) and serotonin transporter (5-HTT) membrane proteins in the caudate-putamen (CPu) and nucleus accumbens (NAc) of rat brain was assessed at seven ages at postnatal days (PD) 7-60, by in vitro ..
  47. doi Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease
    Elke Hattingen
    Institute of Neuroradiology, J W Goethe University Schleusenweg 2 16, 60528 Frankfurt Main, Germany
    Brain 132:3285-97. 2009
    ..In the putamen and midbrain of both Parkinson's disease groups, we found a bilateral reduction of high-energy phosphates such as ..
  48. ncbi The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamen
    Yilin Li
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Neuropsychopharmacology 28:1082-5. 2003
    ..of this study was two-fold: (1) to determine whether amphetamine has similar effects on MSNs in the caudate-putamen (CPu) and (2) to determine if this effect is localized to distal dendrites, the site of convergence of dopamine (..
  49. ncbi Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen
    Michal T Krauze
    Department of Neurological Surgery, Laboratory of Molecular Therapeutics, University of California, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Exp Neurol 196:104-11. 2005
    ..MR method for monitoring CED delivery of liposomes in primate CNS allowed us to closely monitor infusions of putamen. Our findings indicate that CED in putamen is associated with perivascular transport of liposomes, throughout CNS ..
  50. pmc Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study
    Ji H Ko
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Eur J Neurosci 28:2147-55. 2008
    ..cTBS of the left DLPFC impaired MCST performance and dopamine release in the ipsilateral caudate-anterior putamen and contralateral caudate nucleus, as compared to cTBS of the vertex (control)...
  51. ncbi Cortical and putamen age-related changes in the microvessel density and astrocyte deficiency in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats
    Marie Françoise Ritz
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Curr Neurovasc Res 6:279-87. 2009
    ..SP-SHR) as a models for SVD, we analysed the effect of hypertension on the microvasculature in the cortex and putamen, and on its relationship with astrocytes in animals aged 2 to 9 months...
  52. ncbi Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning
    Masahiko Haruno
    Department of Cognitive Neuroscience Computational Neuroscience Labs, Advanced Telecommunication Research Institute, Sorakugun, Kyoto 619 0288, Japan
    J Neurophysiol 95:948-59. 2006
    ..However, the putamen and caudate nucleus are embedded in distinct cortico-striatal loop circuits, predominantly connected to motor-..
  53. ncbi Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    By using diffusion-weighted imaging (DWI), we have recently shown abnormal diffusivity in the putamen of patients with the Parkinson variant of multiple system atrophy (MSA-P) which also correlated with disease severity, indicating the ..
  54. ncbi Transcriptional changes in multiple system atrophy and Parkinson's disease putamen
    Ina R Vogt
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Exp Neurol 199:465-78. 2006
    ..in MSA, we chose CNS regions differentially affected in MSA and PD for comparative gene expression profiling: putamen, cerebellum and occipital cortex...
  55. ncbi Ultrastructural localization of the CB1 cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus
    J J Rodriguez
    Department of Neurology and Neuroscience, Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 21:823-33. 2001
    ..subtype 1 receptor (CB1R) and the mu-opioid receptor (muOR), in the striatal circuitry originating in the caudate putamen nucleus (CPN). Thus, the CB1R and muOR may show similar targeting in the CPN...
  56. ncbi Neuronal encoding of reward value and direction of actions in the primate putamen
    Yukiko Hori
    Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Neurophysiol 102:3530-43. 2009
    ..To address this issue, we investigated the activities of presumed projection neurons in the putamen of macaque monkeys performing a visually instructed GO-NOGO button-press task for large and small rewards...
  57. ncbi Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:847-52. 2006
    ..neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while ..
  58. ncbi Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neurotrophic factor in nestin-expressing reactive astrocytes in the caudate-putamen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/Bl mice
    Liang Wei Chen
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, People s Republic of China
    J Comp Neurol 497:898-909. 2006
    ..B staining, and this was accompanied by an increase in nestin-expressing astrocytes within the caudate-putamen. The number of nestin-positive reactive astrocytes in the caudate-putamen peaked within 3-5 days following MPTP ..
  59. doi Increased activity of mitochondrial aldehyde dehydrogenase (ALDH) in the putamen of individuals with Alzheimer's disease: a human postmortem study
    Tanja Maria Michel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    J Alzheimers Dis 19:1295-301. 2010
    ..We found that the mitochondrial ALDH activity was significantly increased only in the putamen of patients suffering from AD compared to controls...
  60. doi An fMRI motor activation paradigm demonstrates abnormalities of putamen activation in females with panic disorder
    William R Marchand
    Department of Veterans Affairs VISN 19 MIRECC, Salt Lake City, Utah 84148, USA
    J Affect Disord 116:121-5. 2009
    The neurobiology of panic disorder is incompletely understood. The aim of this study was to determine if functional abnormalities of the putamen occur in panic disorder.
  61. ncbi Effect of chronic "binge cocaine" on basal levels and cocaine-induced increases of dopamine in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice
    Yong Zhang
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 50:191-9. 2003
    ..of chronic "binge" pattern cocaine administration on basal and cocaine-induced dopamine levels in the caudate putamen and nucleus accumbens of C57BL/6J and 129/J mice...
  62. ncbi Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study
    D A Cousins
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 61:1191-5. 2003
    To compare the volume of the putamen on MRI in subjects with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) and age-matched normal control subjects, along with the relationship between putamen volume and severity of both ..
  63. ncbi T2*-weighted MRI in diagnosis of multiple system atrophy. A practical approach for clinicians
    Friederike von Lewinski
    Paracelsus Elena Klinik, Klinikstr 16, 34128 Kassel, Germany
    J Neurol 254:1184-8. 2007
    ..T2*-weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore may support the clinical differential diagnosis between MSA and PD...
  64. ncbi Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice
    Stefan D Schlussman
    The Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 974:249-53. 2003
    Preprodynorphin mRNA was measured in the nucleus accumbens (NAc) and caudate putamen (CPu) after 3-day 'binge' pattern cocaine administration in C57BL/6J and 129/J mice, strains which differ in behavior and in dopamine increases in the ..
  65. ncbi Disorganized somatotopy in the putamen of patients with focal hand dystonia
    C Delmaire
    Department of Neuroradiology, Hopital de la Pitie Salpetriere, Paris, France
    Neurology 64:1391-6. 2005
    ..To explore the selectivity of neuronal somatotopic representation in the striatum of patients with unilateral task-specific dystonia of the right arm...
  66. ncbi Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  67. ncbi Behavioral effects of somatostatin microinjected into caudate putamen
    R Tashev
    Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Neuropeptides 35:271-5. 2001
    ..present study examined the behavioral responses to bilateral microinjections of somatostatin (SRIF) into caudate putamen of male Wistar rats...
  68. ncbi Field strengths and sequences influence putaminal MRI findings in multiple system atrophy
    H Watanabe
    Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    Neurology 62:671. 2004
  69. doi Modulation of neuronal activity in the monkey putamen associated with changes in the habitual order of sequential movements
    Marc Deffains
    Laboratoire de Neurobiologie de la Cognition, Université de Provence Centre National de la Recherche Scientifque, Marseille, France
    J Neurophysiol 104:1355-69. 2010
    ..We recorded single neurons in the posterior putamen of two monkeys performing an overlearned sequence of arm reaching movements to examine whether task-related ..
  70. pmc Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
    Functional neuroimaging and lesion studies have frequently reported thalamic and putamen activation during reading and speech production...
  71. pmc Mitochondrial abnormalities in the putamen in Parkinson's disease dyskinesia
    Alipi V Naydenov
    Department of Pharmacology and Psychiatry, Vanderbilt University, Nashville, TN, 37232 8548, USA
    Acta Neuropathol 120:623-31. 2010
    ..We hypothesized that bioenergetic function in the putamen might play a crucial role in the development of dyskinesias...
  72. ncbi Adrenomedullin over-expression in the caudate-putamen of the adult rat brain after ischaemia-reperfusion injury
    Juan Manuel Encinas
    Department of Neuroanatomy and Cell Biology, Instituto de Neurobiología Ramón y Cajal, CSIC, Avenida Doctor del Arce 37, 28002 Madrid, Spain
    Neurosci Lett 329:197-200. 2002
    The expression of adrenomedullin (AM) was studied in the caudate-putamen of the adult rat brain using a global cerebral ischaemia model...
  73. ncbi Dysarthria, progressive parkinsonian features and symmetric necrosis of putamen in a family with painful lipomas (Dercum disease variant)
    M Kyllerman
    Section of Neuropediatrics, The Queen Silvia Children s Hospital, Goteborg, Sweden
    Neuropediatrics 33:69-72. 2002
    ..MRI showed bilateral increasing cystic lesions in the basal parts of the putamen. No other abnormalities were detected...
  74. ncbi Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys
    Christian Pifl
    Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Neurochem Int 49:519-24. 2006
    ..We found that in the asymptomatic MPTP monkeys the DOPAC/DA ratios in putamen and caudate nucleus were shifted with high statistical significance 1.9-5...
  75. pmc Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype
    Michelle L Stephens
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, KY 40536 0098, USA
    J Neurosci Methods 185:264-72. 2010
    ..array prototype (Spencer-Gerhardt-2 (SG-2)) to measure tonic and phasic glutamate neurotransmission in the putamen of unanesthetized non-human primates. We also showed that the SG-2 remains functional following sterilization...
  76. doi Putaminal lesion in multiple system atrophy: postmortem MR-pathological correlations
    Eiji Matsusue
    Department of Pathophysiological and Therapeutic Science, Division of Radiology, Faculty of Medicine, Tottori University, Yonago, Tottori Prefecture, Japan
    Neuroradiology 50:559-67. 2008
    ..Posterior putaminal atrophy, putaminal T2-hyper and/or hyposignal changes have been observed in patients with multiple system atrophy (MSA) with parkinsonism...
  77. ncbi Effects of monoamine uptake inhibitors given early postnatally on monoamines in the brain stem, caudate/putamen and cortex, and on dopamine D1 and D2 receptors in the caudate/putamen
    I Hilakivi
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    J Neural Transm Gen Sect 102:139-48. 1995
    ..9% sodium chloride once a day during the second and third weeks after birth, and brain stem, caudate/putamen and cortical monoamines, and caudate/putamen dopamine D1 (3[H]SCH 23390) and D2 (3[H]spiroperidol) receptor ..
  78. doi Putaminal abnormality on 3-T magnetic resonance imaging in early parkinsonism-predominant multiple system atrophy
    Jee Young Lee
    Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea
    J Neurol 257:2065-70. 2010
    ..as presence of atrophy, signal hypointensity, and abnormal disruption of the hyperintense lateral rim of the putamen. The sum scores for putaminal abnormality were calculated from the presence of each item...
  79. doi The neural basis of central proprioceptive processing in older versus younger adults: an important sensory role for right putamen
    Daniel J Goble
    Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, Department of Biomedical Kinesiology, K U Leuven, Belgium
    Hum Brain Mapp 33:895-908. 2012
    ..A significant decrease in neural activity was also found in a cluster of right putamen voxels for the older age group when compared with the younger age group...
  80. doi Increased putamen and callosal motor subregion in treatment-naïve boys with Tourette syndrome indicates changes in the bihemispheric motor network
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University Medical Centre, Dresden, Germany
    J Child Psychol Psychiatry 52:306-14. 2011
    ..In the present study, these confounders were excluded to identify differences in basal ganglia and corpus callosum size that can be ascribed more probably to Tourette syndrome per se...
  81. ncbi Striatal dopamine release during unrewarded motor task in human volunteers
    Rajendra D Badgaiyan
    Division of Nuclear Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neuroreport 14:1421-4. 2003
    ..Rapid displacement of the ligand from the posterior putamen and the caudate immediately after the task initiation suggested striatal dopamine release during task performance...
  82. ncbi Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context
    Susan M Ferguson
    Neuroscience Program, University of Michigan, Ann Arbor 48109, USA
    J Neurochem 86:33-44. 2003
    ..is thought to be critical for psychostimulant drugs to induce immediate early genes (IEGs) in the caudate-putamen (CPu)...
  83. pmc Multiple regional 1H-MR spectroscopy in multiple system atrophy: NAA/Cr reduction in pontine base as a valuable diagnostic marker
    H Watanabe
    Department of Neurology, Nagoya University Graduate School of Medicine, Japan
    J Neurol Neurosurg Psychiatry 75:103-9. 2004
    ..We performed (1)H-MR spectroscopy ((1)H-MRS) on multiple brain regions to determine the metabolite pattern and diagnostic utility of (1)H-MRS in multiple system atrophy (MSA)...
  84. ncbi Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment
    Yanbo Zhang
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, 103 Wiggins Rd, Saskatoon, Sask S7N 5E4, Canada
    Neurosci Lett 420:66-71. 2007
    ..of HAL caused significant increase in locomotor activity and lower levels of TH immunoreactivity in the caudate putamen of the striatum...
  85. pmc Dopamine is released in the striatum during human emotional processing
    Rajendra D Badgaiyan
    Department of Psychiatry, University at Buffalo, Buffalo, NY, USA
    Neuroreport 21:1172-6. 2010
    ..Analysis of the data indicated that the task performance is associated with dopamine release in the head of caudate and in the dorsal putamen bilaterally.
  86. ncbi Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: comparison of NMDA, AMPA, and kainate receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA
    Synapse 30:227-35. 1998
    ..3H]MK-801), AMPA ([3H]CNQX), and kainate ([3H]kainic acid) glutamate (GLU) ionotropic receptors in rat caudate-putamen (CPu) and nucleus accumbens (NAc) were examined by quantitative autoradiography following: 1) unilateral surgical ..
  87. ncbi Putamen FDOPA uptake and its relationship tot cognitive functioning in PD
    Marije van Beilen
    Department of Neurology, University Medical Center Groningen, The Netherlands
    J Neurol Sci 248:68-71. 2006
    ..The putamen is part of the motor loop, while the caudate nucleus is part of the motor loop but also of the cognitive loop...
  88. ncbi Caudate and putamen volumes in good and poor outcome patients with schizophrenia
    Monte S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, 1 Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 64:53-62. 2003
    ..The caudate nucleus and putamen were traced on axial slices from the most superior extent of the caudate to the most inferior point where the ..
  89. ncbi Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task
    M Inase
    Supermolecular Science Division, Electrotechnical Laboratory, Tsukuba, Japan
    Exp Brain Res 117:207-18. 1997
    Using multibarreled glass micropipettes, we recorded single-unit activity in the putamen, and iontopho retically applied D1 and D2 dopamine receptor agonists (SKF38393, quinpirole) and antagonists (SCH23390, sulpiride) while two monkeys ..
  90. doi Reduced volume of the putamen in REM sleep behavior disorder patients
    Timothy M Ellmore
    Department of Neurosurgery, University of Texas Houston Medical School, MSB 7 044, 6431 Fannin St, Houston, TX 77030, USA
    Parkinsonism Relat Disord 16:645-9. 2010
    ..We hypothesized that REM sleep behavior disorder (RBD) patients, at risk for developing PD, will demonstrate a pattern of neuronal degeneration reflected in reduced striatal volumes on T1-weighted MRI...
  91. ncbi Hemichorea-hemiballism associated with hyperintense putamen on T1-weighted MR images: an update and a hypothesis
    Din E Shan
    Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
    Acta Neurol Taiwan 13:170-7. 2004
    In 1998 some patients with hyperglycemia-related hemichorea-hemiballism have been reported with a hyperintense putamen on T1-weighted MR images, presumably resulting from petechial hemorrhage...
  92. pmc Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen
    Serge A Mitelman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 113:241-5. 2009
    ..Present longitudinal study was designed to investigate progressive differences in striatal volumes among chronic schizophrenia patients with different outcomes and healthy subjects...
  93. doi A follow-up study on 6-[18F]fluoro-L-dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen
    Anna Brück
    Turku PET Centre, University of Turku, Turku, Finland
    Mov Disord 24:1009-15. 2009
    ..Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms...
  94. ncbi Hyperintense putaminal rim at 3T reflects fewer ferritin deposits in the lateral marginal area of the putamen
    S Fujii
    Division of Radiology, Department of Pathophysiological and Therapeutic Science, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    AJNR Am J Neuroradiol 28:777-81. 2007
    ..The aim of this study was to clarify the cause of hyperintense putaminal rim (HPR) on the basis of 3T MR imaging-pathologic correlations...
  95. ncbi Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey
    Hitoshi Kita
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 26:6554-62. 2006
    ..Here, we characterized the responses of pallidal neurons to single and burst stimulation of the putamen (Put) in awake monkeys...
  96. pmc Effects of acute cocaine on ERK and DARPP-32 phosphorylation pathways in the caudate-putamen of Fischer rats
    Wei Lun Sun
    Department of Psychology, Hunter College, City University of New York, 695 Park Ave, New York, NY 10021, USA
    Brain Res 1178:12-9. 2007
    ..element-binding protein (CREB) kinase, pp90 ribosomal S6 kinase (RSK), and c-Fos protein levels in the caudate/putamen of Fischer rats...
  97. ncbi Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus
    Philip Seeman
    Department of Pharmacology, University of Toronto, King s College Circle, Medical Sciences Building, Toronto, Ontario, Canada M5S 1A8
    Synapse 60:205-11. 2006
    ..This method revealed that these two radioligands detected only D2 receptors in the dorsal putamen and the dorsal caudate nucleus, but detected a mixed population of two-thirds D2 and one-third D3 DA receptors in ..
  98. ncbi Focal putamen lesions impair learning in rule-based, but not information-integration categorization tasks
    Shawn W Ell
    Helen Wills Neuroscience Institute and Psychology Department, University of California, Berkeley 94720 1650, United States
    Neuropsychologia 44:1737-51. 2006
    ..Patients with basal ganglia lesions centered in the putamen (6 left side, 1 right side) were tested on rule-based and information-integration visual categorization tasks...
  99. pmc Striatal dopamine release in sequential learning
    Rajendra D Badgaiyan
    Division of Nuclear Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 38:549-56. 2007
    ..that the task induces release of endogenous dopamine in the posterior two-third of dorsomedial aspect of left putamen and the anterior part of the body of caudate bilaterally...
  100. doi Putamen coactivation during motor task execution
    William R Marchand
    Department of Veterans Affairs, VISN 19 MIRECC, Salt Lake City, Utah 84148, USA
    Neuroreport 19:957-60. 2008
    ..During the completion of a unilateral motor task with either hand, each putamen nucleus demonstrated strong coactivation with structures in both hemispheres...
  101. ncbi Dopamine D2 receptors are present in prefrontal cortical afferents and their targets in patches of the rat caudate-putamen nucleus
    Hong Wang
    Division of Neurobiology, Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 442:392-404. 2002
    ..neurons of the substantia nigra pars compacta preferentially terminate in patch-like regions within the caudate putamen nucleus (CPN)...

Research Grants77

  1. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2010
    ..The major component of the basal ganglia, the striatum (or caudate-putamen) processes cortical inputs and subsequently regulates the output nuclei of the basal ganglia through two output ..
  2. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2001
    ..received cultured mesencephalic tissue from four embryos along four 30 to 40 mm needle tracts bilaterally in the putamen. Control patients had burr holes but no actual implantations. No patients were immunosuppressed...
  3. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2000
    ..received cultured mesencephalic tissue from four embryos along four 30 to 40 mm needle tracts bilaterally in the putamen. Control patients had burr holes but no actual implantations. No patients were immunosuppressed...
  4. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..received cultured mesencephalic tissue from four embryos along four 30 to 40 mm needle tracts bilaterally in the putamen. Control patients had burr holes but no actual implantations. No patients were immunosuppressed...
  5. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..samples from different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, amygdala and fronto-cortical regions (cingulate and subgenual cortical areas)..
  6. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh Kumar; Fiscal Year: 2009
    ..samples from different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, amygdala and fronto-cortical regions (cingulate and subgenual cortical areas)..
  7. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..inhibition by CB1 and D2 receptors in subregions of the striatum/BG in Gng7 knockout mice, including caudate-putamen, nucleus accumbens and globus pallidus, as well as other CB1 and D2 containing regions such as prefrontal cortex ..
  8. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana Selley; Fiscal Year: 2009
    ..inhibition by CB1 and D2 receptors in subregions of the striatum/BG in Gng7 knockout mice, including caudate-putamen, nucleus accumbens and globus pallidus, as well as other CB1 and D2 containing regions such as prefrontal cortex ..
  9. ORGANIZATION OF THE OUTPUT NUCLEI OF THE BASAL GANGLIA
    IRENA GROFOVA; Fiscal Year: 1992
    The Basal Ganglia (BG) include the caudate nucleus, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. These structures are mutually interconnected and participate in similar functions...
  10. COCAINE INDUCED OPIOID, DOPAMINE AND BEHAVIORAL CHANGES
    ELLEN UNTERWALD; Fiscal Year: 2002
    ..cyclase activity will be assessed by measuring the accumulation of cAMP in the nucleus accumbens, caudate putamen, and olfactory tubercle...
  11. COCAINE INDUCED OPIOID, DOPAMINE AND BEHAVIORAL CHANGES
    ELLEN UNTERWALD; Fiscal Year: 2001
    ..cyclase activity will be assessed by measuring the accumulation of cAMP in the nucleus accumbens, caudate putamen, and olfactory tubercle...
  12. COCAINE INDUCED OPIOID, DOPAMINE AND BEHAVIORAL CHANGES
    ELLEN UNTERWALD; Fiscal Year: 1999
    ..cyclase activity will be assessed by measuring the accumulation of cAMP in the nucleus accumbens, caudate putamen, and olfactory tubercle...
  13. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2006
    ..to chronically deliver GDNF in the freely-moving MPTP-lesioned monkey to evaluate multisite delivery of GDNF (putamen vs. putamen and substantia nigra) to improve the functional restoration of DA systems...
  14. COCAINE INDUCED OPIOID, DOPAMINE AND BEHAVIORAL CHANGES
    ELLEN UNTERWALD; Fiscal Year: 2000
    ..cyclase activity will be assessed by measuring the accumulation of cAMP in the nucleus accumbens, caudate putamen, and olfactory tubercle...
  15. Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2010
    ..One of the major telencephalic structures controlling these processes is the striatum (also known as the caudate-putamen)...
  16. Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
    Kenneth Campbell; Fiscal Year: 2009
    ..One of the major telencephalic structures controlling these processes is the striatum (also known as the caudate-putamen)...
  17. FETAL MEMBRANE MATRIX METALLOPROTEINASES IN MONKEYS SPONTANE & ACTH INDUCE LABO
    DREW SADOWSKY; Fiscal Year: 2000
    ..In some brain regions, i.e., the putamen, internal capsule, hippocampus and paraventricular hypothalamus, ER-? was expressed in the female, but not in the ..
  18. Thalamostriatal System in Parkinsonism
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..Projections from the CM terminate in the putamen, completing a movement-related trans-thalamic feedback loop by which basal ganglia output may act to shape ..
  19. Oxytocin Receptors and Social Behavior
    Larry J Young; Fiscal Year: 2012
    ..g. NAcc and caudate putamen) is associated with variation in social behavior in male and female prairie voles at multiple developmental ..
  20. Thalamostriatal System in Parkinsonism
    Thomas Wichmann; Fiscal Year: 2009
    ..Projections from the CM terminate in the putamen, completing a movement-related trans-thalamic feedback loop by which basal ganglia output may act to shape ..
  21. STREP, HOST FACTORS, AUTOANTIBODIES & TOURETTE SYNDROME
    Harvey Singer; Fiscal Year: 1999
    ..support of an immune-related hypothesis for TS, our preliminary studies showed that a) serum antibodies to human putamen, but not to caudate or globus pallidus, are significantly increased in children with TS and b) after ..
  22. STREP, HOST FACTORS, AUTOANTIBODIES & TOURETTE SYNDROME
    Harvey Singer; Fiscal Year: 2000
    ..support of an immune-related hypothesis for TS, our preliminary studies showed that a) serum antibodies to human putamen, but not to caudate or globus pallidus, are significantly increased in children with TS and b) after ..
  23. Anatomical and Physiological Characterization of the Thalamostriatal System
    KALYNDA GONZALES; Fiscal Year: 2010
    ..to the striatum in regulating the spontaneous and CM-stimulation induced neuronal activity in TANs in the primate putamen and (2) To define the microcircuitry and chemical phenotype of GABAergic synaptic inputs along the ..
  24. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..In the developing caudate-putamen (neostriatum), these boundaries surround different compartments of a neostriatal mosaic, the patch and matrix, ..
  25. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2006
    ..can deliver GDNF chronically in the freely-moving MPTP-lesioned monkey to evaluate multisite delivery of GDNF (putamen vs. putamen + substantia nigra) to improve the functional restoration of DA systems...
  26. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2009
    ..can deliver GDNF chronically in the freely-moving MPTP-lesioned monkey to evaluate multisite delivery of GDNF (putamen vs. putamen + substantia nigra) to improve the functional restoration of DA systems...
  27. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2007
    ..can deliver GDNF chronically in the freely-moving MPTP-lesioned monkey to evaluate multisite delivery of GDNF (putamen vs. putamen + substantia nigra) to improve the functional restoration of DA systems...
  28. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2005
    ..can deliver GDNF chronically in the freely-moving MPTP-lesioned monkey to evaluate multisite delivery of GDNF (putamen vs. putamen + substantia nigra) to improve the functional restoration of DA systems...
  29. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2006
    ..regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
  30. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2005
    ..regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
  31. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2004
    ..regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
  32. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2003
    ..regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
  33. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2002
    ..regions controlling these processes are the cerebral cortex and the striatum (also known as the caudate-putamen)...
  34. NEURAL CONTROL OF VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 1992
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  35. NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 2001
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  36. NEURAL CONTROL OF VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 1991
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  37. NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 1999
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  38. NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 2000
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  39. NEURAL CONTROL OF VOLUNTARY MOVEMENTS
    Jerome Sanes; Fiscal Year: 1993
    ..Human subjects with two types of pathology-Parkinson's disease (ON and OFF dopaminergic medication) and focal putamen lesion-will be studied to test hypotheses that the basal ganglia: (1) calibrate muscle activity during changing ..
  40. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2005
    ..of conditioned fear whereas infusion of comparable doses into the central (Ce), basolateral (Bla) or caudate-putamen had no effect...
  41. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2009
    ..of conditioned fear whereas infusion of comparable doses into the central (Ce), basolateral (Bla) or caudate-putamen had no effect...
  42. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2006
    ..of conditioned fear whereas infusion of comparable doses into the central (Ce), basolateral (Bla) or caudate-putamen had no effect...
  43. CENTER FOR THE STUDY OF EMOTION AND ATTENTION
    Peter Lang; Fiscal Year: 2007
    ..of conditioned fear whereas infusion of comparable doses into the central (Ce), basolateral (Bla) or caudate-putamen had no effect...
  44. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2012
    ..of these patients have consistently revealed lesions in the basal ganglia, including the globus pallidus and putamen. Damage in the human brain has been confirmed via autopsy...
  45. MOTOR FUNCTIONS AND FIBER CONNECTIONS OF PALLIDUM
    SAMUEL LILES; Fiscal Year: 1990
    ..experiments are designed to provide new information on the integrative functions of neurons in the pallidum and putamen. Since the putamen has been shown by both anatomical and physiological methods to contain somatotopically ..
  46. CHARACTERIZATION OF A NEURON-SPECIFIC PHOSPHOPROTEIN
    Samuel Gandy; Fiscal Year: 1990
    ..which include Huntington's disease (caudate), Parkinson's disease (substantia nigra), and the dystonias (putamen and globus pallidus)...
  47. AGE RELATED DECLINES IN MOVEMENT FUNCTIONS IN RHESUS MONKEYS
    Greg Gerhardt; Fiscal Year: 1999
    ..These studies will be carried out in the caudate nucleus, putamen, and nucleus accumbens of the three age groups of monkeys...
  48. AGE RELATED DECLINES IN MOVEMENT FUNCTIONS IN RHESUS MONKEYS
    Greg Gerhardt; Fiscal Year: 2001
    ..These studies will be carried out in the caudate nucleus, putamen, and nucleus accumbens of the three age groups of monkeys...
  49. HIGH FIELD MRI IN PARKINSONS DISEASE
    Jay Gorell; Fiscal Year: 1999
    ..However, the clinical significance of iron accumulation in SN, or elsewhere in basal ganglia (e.g., putamen [PUT] or globus pallidus [GP] in PD, has not been defined in living human subjects...
  50. AGE RELATED DECLINES IN MOVEMENT FUNCTIONS IN RHESUS MONKEYS
    Greg Gerhardt; Fiscal Year: 2000
    ..These studies will be carried out in the caudate nucleus, putamen, and nucleus accumbens of the three age groups of monkeys...
  51. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2009
    ..from bone marrow, referred to as mesenchymal stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  52. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2007
    ..from bone marrow, referred to as mesenchymal stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  53. The Role of Omega-3 Fatty Acids in Adolescent Depression
    Vilma Gabbay; Fiscal Year: 2009
    ..MDD, 1) Compared to placebo, omega-3FA will lead to significantly lower concentrations of striatal (caudate and putamen) and anterior cingulate cortex (ACC) tCho, tCr, and greater GABA concentrations in the ACC;2) improvement with ..
  54. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2009
    ..from bone marrow, referred to as mesenchymal stem cells (MSCs) will be injected unilaterally into the caudate putamen of infant rhesus macaques (Macaca mulatta) using stereotaxic coordinates determined by MRI...
  55. Neostriatal Visual Processing & Initiation of Movement
    Emad Eskandar; Fiscal Year: 2005
    ..The input nuclei of the basal ganglia in primates include the caudate and putamen. The output nuclei include the Gpi and the substantia nigra pars reticulata...
  56. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew Miller; Fiscal Year: 2009
    ..ganglia glucose metabolism and increased uptake of the DA precursor, [18F]fluorodopa (FDOPA), in caudate and putamen. To further characterize these IFN-alpha effects on DA pathways, we have recently developed an animal model of ..
  57. Neostriatal Visual Processing & Initiation of Movement
    Emad Eskandar; Fiscal Year: 2004
    ..The input nuclei of the basal ganglia in primates include the caudate and putamen. The output nuclei include the Gpi and the substantia nigra pars reticulata...
  58. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2010
    ..ganglia glucose metabolism and increased uptake of the DA precursor, [18F]fluorodopa (FDOPA), in caudate and putamen. To further characterize these IFN-alpha effects on DA pathways, we have recently developed an animal model of ..
  59. Schizophrenia Data and Software Tool Federation using BIRN Infrastructure
    Lei Wang; Fiscal Year: 2009
    ..e., hippocampus, amygdala, thalamus, caudate nucleus, nucleus accumbens, putamen and globus pallidus)...
  60. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 1999
    ..determine if regional brain iron deficiency alters the release and re-uptake of DA in synaptosomes from caudate-putamen and to determine if the number of functioning transporter mRNA for these transporters are altered, 3) determine ..
  61. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  62. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  63. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  64. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
    ..By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral cortex in the same TS subjects...
  65. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2000
    ..determine if regional brain iron deficiency alters the release and re-uptake of DA in synaptosomes from caudate-putamen and to determine if the number of functioning transporter mRNA for these transporters are altered, 3) determine ..
  66. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2010
    ..Increased uptake and decreased release of the DA precursor, [18F]fluorodopa, in the caudate and putamen of IFN-alpha-treated patients has also been observed...
  67. THE CONNECTIONAL ORGANIZATION OF THE THALAMUS
    JOHN HARTING; Fiscal Year: 2000
    The centromedian nucleus (CM-Pf) projects to striatal (caudate and putamen) neurons that are key components of basal ganglia pathways that regulate movement...
  68. THE CONNECTIONAL ORGANIZATION OF THE THALAMUS
    JOHN HARTING; Fiscal Year: 2001
    The centromedian nucleus (CM-Pf) projects to striatal (caudate and putamen) neurons that are key components of basal ganglia pathways that regulate movement...
  69. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin Teicher; Fiscal Year: 2009
    ..0). The second marker is a measure of regional T2-relaxation time (T2RT) in left putamen and right dorsolateral prefrontal cortex...
  70. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin H Teicher; Fiscal Year: 2010
    ..0). The second marker is a measure of regional T2-relaxation time (T2RT) in left putamen and right dorsolateral prefrontal cortex...
  71. Basal Ganglia Functions in Huntington's Disease: Genetic Mouse Models
    ELIZABETH ABERCROMBIE; Fiscal Year: 2009
    ..of the brain are the cerebral cortex and the subcortical nuclei of the basal ganglia, in particular the caudate/putamen. There currently is no satisfactory therapy for the disease and the hope for a cure remains distant despite the ..
  72. Basal Ganglia Functions in Huntington's Disease: Genetic Mouse Models
    Elizabeth D Abercrombie; Fiscal Year: 2010
    ..of the brain are the cerebral cortex and the subcortical nuclei of the basal ganglia, in particular the caudate/putamen. There currently is no satisfactory therapy for the disease and the hope for a cure remains distant despite the ..
  73. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    VIRGINIA PICKEL; Fiscal Year: 1992
    Endogenous opiate peptides (enkephalins and dynorphin) within the dorsal (caudate-putamen nuclei, CPN) and ventral (nucleus accumbens septi) striatum have been implicated in motor and sensory responses to peripheral stimuli and in the ..
  74. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    VIRGINIA PICKEL; Fiscal Year: 2001
    Endogenous opiate peptides (enkephalins and dynorphin) within the dorsal (caudate-putamen nuclei, CPN) and ventral (nucleus accumbens septi) striatum have been implicated in motor and sensory responses to peripheral stimuli and in the ..
  75. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    VIRGINIA PICKEL; Fiscal Year: 2000
    Endogenous opiate peptides (enkephalins and dynorphin) within the dorsal (caudate-putamen nuclei, CPN) and ventral (nucleus accumbens septi) striatum have been implicated in motor and sensory responses to peripheral stimuli and in the ..
  76. Role of Mnbk in Downs Syndrome brain development & aging
    Jerzy Wegiel; Fiscal Year: 2004
    ..system ( substantia nigra, pedunculopontine tegmental nucleus, caudal intralaminar thalamus, caudate nucleus, putamen, globus pallidus, nucleus accumbens, motor cortex, and cerebellum) in 44 people with DS...