globus pallidus

Summary

Summary: The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.

Top Publications

  1. ncbi Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
  2. ncbi Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
  3. ncbi Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
  4. ncbi Activity patterns in a model for the subthalamopallidal network of the basal ganglia
    D Terman
    Department of Mathematics, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 22:2963-76. 2002
  5. ncbi Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
  6. ncbi Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network
    P J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Neuroscience 106:313-30. 2001
  7. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
    Chantal Francois
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2055-70. 2004
  8. ncbi Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey
    Marjorie E Anderson
    Department of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurophysiol 89:1150-60. 2003
  9. ncbi A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus
    D Plenz
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Nature 400:677-82. 1999
  10. pmc The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons
    Pierre Flandin
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158 2611, USA
    J Neurosci 30:2812-23. 2010

Research Grants

  1. Basal Ganglia and Higher Cortical Function
    Peter L Strick; Fiscal Year: 2010
  2. Extrastriatal functions of dopamine
    THOMAS N WICHMANN; Fiscal Year: 2010
  3. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2010
  4. Basal Ganglia and Higher Cortical Function
    PETER STRICK; Fiscal Year: 2009
  5. Cortical connections with the limbic territory of the basal ganglia
    Michelle Morrow; Fiscal Year: 2007
  6. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2010
  7. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
  8. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2010
  9. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 1993
  10. GABA RECEPTORS IN THE THALAMUS
    Yoland Smith; Fiscal Year: 2005

Detail Information

Publications234 found, 100 shown here

  1. ncbi Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..To examine this hypothesis, we looked for correlations in the discharge activity of pairs of neurons in the globus pallidus internus (GPi), globus pallidus externus (GPe), and the substantia nigra pars reticulata (SNr)...
  2. ncbi Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
    ..We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease...
  3. ncbi Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
    ..we investigated the effects of STN HFS on neuronal activity of the internal and external segment of the globus pallidus (GPi and GPe, respectively) in two rhesus monkeys rendered parkinsonian by administration of 1-methyl-4-..
  4. ncbi Activity patterns in a model for the subthalamopallidal network of the basal ganglia
    D Terman
    Department of Mathematics, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 22:2963-76. 2002
    ..a conductance-based computational network model of the subthalamic nucleus and the external segment of the globus pallidus in the indirect pathway of the basal ganglia...
  5. ncbi Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
    ..hyperdirect' pathway conveys powerful excitatory effects from the motor-related cortical areas to the globus pallidus, bypassing the striatum, with shorter conduction time than effects conveyed through the striatum...
  6. ncbi Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network
    P J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Neuroscience 106:313-30. 2001
    The subthalamic nucleus-globus pallidus network plays a central role in basal ganglia function and dysfunction...
  7. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
    Chantal Francois
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2055-70. 2004
    ..be induced by microinjections of bicuculline, a GABAergic antagonist, into different parts of the external globus pallidus (GPe) in monkeys...
  8. ncbi Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey
    Marjorie E Anderson
    Department of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurophysiol 89:1150-60. 2003
    The reduction in symptoms of Parkinson's disease produced by high-frequency stimulation (HFS) in the internal globus pallidus (GPi) has been proposed to be due to stimulus-induced inactivation of pallidal neurons and resulting ..
  9. ncbi A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus
    D Plenz
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Nature 400:677-82. 1999
    ..Here we show that the excitatory STN and inhibitory, external globus pallidus (GPe) form a feedback system that engages in synchronized bursting...
  10. pmc The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons
    Pierre Flandin
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158 2611, USA
    J Neurosci 30:2812-23. 2010
    We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele...
  11. ncbi Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network
    Mark D Bevan
    Dept of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
    Trends Neurosci 25:525-31. 2002
    ..processes at the levels of single neurons and neuronal networks in the subthalamic nucleus (STN) and external globus pallidus (GPe) are associated with the operation of the basal ganglia in health and in Parkinson's disease (PD)...
  12. pmc Dichotomous organization of the external globus pallidus
    Nicolas Mallet
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology and Oxford Parkinson s Disease Centre, University of Oxford, Oxford OX1 3TH, UK
    Neuron 74:1075-86. 2012
    ..We have defined an analogous division of labor in the external globus pallidus (GPe) of Parkinsonian rats, showing that the distinct temporal activities of two populations of GPe neuron in..
  13. ncbi Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mov Disord 21:S259-83. 2006
    ..of how various mapping strategies modify target selection and outcome following subthalamic nucleus (STN), globus pallidus internus (GPi), and ventralis intermedius (Vim) deep brain stimulation...
  14. pmc External globus pallidus stimulation modulates brain connectivity in Huntington's disease
    Noémie Ligot
    Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Cereb Blood Flow Metab 31:41-6. 2011
    ..with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD)...
  15. ncbi Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice
    Kenji Takahashi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Biol Psychiatry 62:148-57. 2007
    ..We attempted to clarify the neuronal circuits underlying the control of PPI of the startle reflex in mice...
  16. ncbi Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism
    A Raz
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    J Neurosci 20:8559-71. 2000
    ..hand tremor and simultaneous activity of several neurons in the external and internal segments of the globus pallidus (GPe and GPi) in two vervet monkeys, before and after systemic treatment with 1-methyl-4-phenyl-1,2,3,6-..
  17. doi Functional characterization of GABAergic pallidopallidal and striatopallidal synapses in the rat globus pallidus in vitro
    Robert E Sims
    Biomedical Sciences, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Eur J Neurosci 28:2401-8. 2008
    As a central integrator of basal ganglia function, the external segment of the globus pallidus (GP) plays a critical role in the control of voluntary movement...
  18. doi Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
    Bai Yun Zeng
    NDRG, School of Biomedical and Health Sciences, King s College, London, UK
    Neurobiol Dis 40:599-607. 2010
    ..axon varicosities was noted in the dorsal caudate and putamen of MPTP-intoxicated monkeys but not the globus pallidus. In MPTP-intoxicated marmosets that had received chronic levodopa treatment to induce dyskinesia, a further ..
  19. pmc Deep brain stimulation of the globus pallidus internus in the parkinsonian primate: local entrainment and suppression of low-frequency oscillations
    Kevin W McCairn
    Department of Neurobiology, University of Pittsburgh, 4047 BST 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 101:1941-60. 2009
    ..seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease...
  20. pmc Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidus
    M Desmurget
    Department of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 99:1057-76. 2008
    ..control, we examined the effects of muscimol-induced inactivations in the skeletomotor region of the internal globus pallidus (sGPi) on visually directed reaching...
  21. ncbi Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeys
    Arthur Leblois
    Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Eur J Neurosci 24:1201-8. 2006
    ..been proposed that bradykinesia (motor slowness) is related either to a modification of the activity of the globus pallidus internalis (GPi), the main output structure, or to a loss of spatial selectivity of the extrapyramidal motor ..
  22. pmc The globus pallidus sends reward-related signals to the lateral habenula
    Simon Hong
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Neuron 60:720-9. 2008
    As a major output station of the basal ganglia, the globus pallidus internal segment (GPi) projects to the thalamus and brainstem nuclei thereby controlling motor behavior...
  23. ncbi Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
  24. ncbi Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease
    Valerie C Anderson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97201, USA
    Arch Neurol 62:554-60. 2005
    Deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) has been reported to relieve motor symptoms and levodopa-induced dyskinesia in patients with advanced Parkinson disease (PD)...
  25. ncbi Effects of apomorphine on subthalamic nucleus and globus pallidus internus neurons in patients with Parkinson's disease
    R Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 86:249-60. 2001
    ..agonist, on the firing activity of neurons in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) in patients with Parkinson's disease (PD)...
  26. pmc Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus-pallidal circuits
    Leonid L Rubchinsky
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 100:14427-32. 2003
    ..The loss of this ability leads to hypokinesia, known PD motor deficits characterized by a slowness or inability to switch between motor programs...
  27. ncbi A single-cell analysis of intrinsic connectivity in the rat globus pallidus
    Ahmed R Sadek
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom
    J Neurosci 27:6352-62. 2007
    GABAergic neurons of the globus pallidus (GP) play critical roles in basal ganglia function by virtue of their widespread axonal projections to all parts of the basal ganglia. They also possess local axon collaterals...
  28. ncbi Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat
    A Benazzouz
    Laboratoire de Neurobiologie Preclinique, INSERM U 318, CHU Pavillon B, BP 217, 38043, Grenoble, France
    Neuroscience 99:289-95. 2000
    ..6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%)...
  29. ncbi Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of parkinsonism
    Gali Heimer
    Department of Physiology, the Interdisciplinary Center for Neural Computation and the Eric Roland Center for Neurodegenerative Diseases, The Hebrew University Hadassah Medical School, Jerusalem, 91120 Israel
    J Neurosci 22:7850-5. 2002
    ..After MPTP treatment, firing rates decreased in the external segment of the globus pallidus (GP(e)) and increased in the internal segment (GP(i))...
  30. doi Short-term depression of synaptic transmission during stimulation in the globus pallidus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
    Yaara Erez
    Gonda Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurosci 29:7797-802. 2009
    High-frequency stimulation (HFS) in the globus pallidus is used to ameliorate clinical symptoms of Parkinson's disease, dystonia, and other disorders...
  31. pmc Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations
    S J Hayflick
    Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    AJNR Am J Neuroradiol 27:1230-3. 2006
    ..We investigated correlations between brain MR imaging changes, mutation status, and clinical disease features...
  32. doi MR imaging findings in hepatic encephalopathy
    A Rovira
    Magnetic Resonance Unit, Department of Radiology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    AJNR Am J Neuroradiol 29:1612-21. 2008
    ..It is likely that MR imaging will be increasingly used to evaluate the mechanisms involved in the pathogenesis of HE and to assess the effects of therapeutic measures focused on correcting brain edema in these patients...
  33. ncbi Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation
    David C Dorman
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709 2137, USA
    Toxicol Sci 92:219-27. 2006
    ..Monkeys exposed to MnSO(4) at > or = 0.06 mg Mn/m(3) developed increased manganese concentrations in the globus pallidus, putamen, olfactory epithelium, olfactory bulb, and cerebellum...
  34. ncbi Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency
    Keith M Erikson
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    J Nutr Biochem 15:335-41. 2004
    ..in the cerebellum and caudate putamen; and increasing manganese concentrations in caudate putamen, globus pallidus and substantia nigra. Furthermore, there was a significant effect of iron deficiency (P < 0...
  35. ncbi Acute stimulation in the external segment of the globus pallidus improves parkinsonian motor signs
    Jerrold L Vitek
    Emory University School of Medicine, Atlanta, Georgia, USA
    Mov Disord 19:907-15. 2004
    ..High frequency (>100Hz) electrical stimulation in both the external (GPe) and internal (GPi) segments of the globus pallidus was effective in improving parkinsonian motor signs...
  36. doi Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus
    Raul Martínez-Fernández
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1922-30. 2011
    ..describes our experience with patients with severe refractory Gilles de la Tourette syndrome treated with globus pallidus internus deep brain stimulation...
  37. doi Deep brain stimulation of the internal globus pallidus in dystonia: target localisation under general anaesthesia
    M O Pinsker
    Department of Neurosurgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Acta Neurochir (Wien) 151:751-8. 2009
    Deep brain stimulation (DBS) of the internal globus pallidus (Gpi) is an effective therapy for various types of dystonia...
  38. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    ..The study reported here directly compared the effects of unilateral DBS in subthalamic nucleus (STN) or globus pallidus (GPi) on QoL in 42 non-demented patients with medication-refractory PD...
  39. pmc Brain penetration effects of microelectrodes and DBS leads in STN or GPi
    J M Mann
    Department of Neurology, University of Florida College of Medicine Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurol Neurosurg Psychiatry 80:794-7. 2009
    ..Secondarily, to evaluate whether the longevity of the MER and lead placement effects were influenced by target location (subthalamic nucleus (STN) or globus pallidus interna (GPi)).
  40. doi An anxiolytic role for CRF receptor type 1 in the globus pallidus
    Yehezkel Sztainberg
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 31:17416-24. 2011
    ..The globus pallidus external (GPe), a main relay center within the basal ganglia that is primarily associated with motor and ..
  41. doi Therapy-refractory Tourette syndrome: beneficial outcome with globus pallidus internus deep brain stimulation
    Sandra Dehning
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Mov Disord 23:1300-2. 2008
    We report on a female patient with Tourette syndrome and a 12-month follow-up after chronic deep brain stimulation in the globus pallidus internus which resulted in excellent remission of motor and vocal tics.
  42. pmc Functional connectivity and integrative properties of globus pallidus neurons
    D Jaeger
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Neuroscience 198:44-53. 2011
    The globus pallidus consists of the external (GPe) and the internal (GPi) segments. The GPe and GPi have different functional roles. The GPe is located centrally within multiple basal ganglia feedforward and feedback connections...
  43. doi Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial
    Vincent J J Odekerken
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet Neurol 12:37-44. 2013
    ..We assessed whether globus pallidus pars interna (GPi) deep brain stimulation (DBS) gives greater functional improvement than does subthalamic ..
  44. doi High-frequency microstimulation in human globus pallidus and substantia nigra
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Medical Sciences Building Room 3302, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Exp Brain Res 205:251-61. 2010
    ..single current pulses delivered from a nearby microelectrode are sufficient to inhibit firing in the internal globus pallidus for tens of milliseconds...
  45. ncbi Patterning of globus pallidus local field potentials differs between Parkinson's disease and dystonia
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Brain 126:2597-608. 2003
    ..dystonia was particularly manifest in the more rostral contact pair, presumed to be within or bridging the globus pallidus externus...
  46. doi Temporal convergence of dynamic cell assemblies in the striato-pallidal network
    Avital Adler
    Department of Medical Neuroscience, Institute of Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Neurosci 32:2473-84. 2012
    ..of projection neurons [striatal medium spiny neurons (MSNs), and neurons in the external segment of the globus pallidus (GPe)], and one neuromodulator group [striatal tonically active neurons (TANs)] from behaving monkeys...
  47. ncbi Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys
    Yoshihisa Tachibana
    Division of System Neurophysiology, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, Myodaiji, Okazaki 444 8585, Japan
    Eur J Neurosci 27:238-53. 2008
    The internal segment of the globus pallidus (GPi) receives motor-related cortical signals mainly through the striatum, the external segment of the globus pallidus (GPe) and the subthalamic nucleus (STN)...
  48. doi Toward an anatomy of disappointment: reward-related signals from the globus pallidus
    Jeff Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
    Neuron 60:530-1. 2008
    The globus pallidus (internal segment, GPi) is traditionally regarded as part of the motor system...
  49. pmc Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration
    Nathan W Schultheiss
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 30:2767-82. 2010
    Synchronization of globus pallidus (GP) neurons and cortically entrained oscillations between GP and other basal ganglia nuclei are key features of the pathophysiology of Parkinson's disease...
  50. ncbi Statistical properties of pauses of the high-frequency discharge neurons in the external segment of the globus pallidus
    Shlomo Elias
    Department of Physiology, The Hebrew University Hadassah Medical School, 91120 Jerusalem, Israel
    J Neurosci 27:2525-38. 2007
    The neurons of many basal ganglia nuclei, including the external and internal globus pallidus (GPe and GPi, respectively) and the substantia nigra pars reticulata (SNr) are characterized by their high-frequency (50-100 spikes/s) tonic ..
  51. ncbi Neostriatal and globus pallidus stimulation induced inhibitory postsynaptic potentials in entopeduncular neurons in rat brain slice preparations
    H Kita
    Department of Anatomy and Neurobiology, The University of Tennessee Memphis, 855 Monroe Avenue, Memphis, TN 38163, USA
    Neuroscience 105:871-9. 2001
    ..that the entopeduncular nucleus of the rat receives GABAergic inputs from both the neostriatum and the globus pallidus. The present study was undertaken to reveal the physiological features of these inputs using the ..
  52. ncbi Globus pallidus internal segment
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    Prog Brain Res 160:135-50. 2007
    The internal segment of the globus pallidus (GP(i)) gathers many bits of information including movement-related activity from the striatum, external segment of the globus pallidus (GP(e)), and subthalamic nucleus (STN), and integrates ..
  53. doi Conditions for the generation of beta oscillations in the subthalamic nucleus-globus pallidus network
    Alejo J Nevado Holgado
    Department of Computer Science, University of Bristol, Bristol BS8 1UB, United Kingdom
    J Neurosci 30:12340-52. 2010
    ..observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus pars externa (GPe)...
  54. pmc HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:85-92. 2011
    ..that is traceable to the emergence of synchronous, rhythmic spiking in neurons of the external segment of the globus pallidus (GPe). The origins of this pathophysiology are poorly defined for the generation of pacemaking...
  55. ncbi Short-term plasticity shapes the response to simulated normal and parkinsonian input patterns in the globus pallidus
    Jesse E Hanson
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:5164-72. 2002
    ..To determine the role of STP in the subthalamic nucleus (STN) to globus pallidus (GP) connection, which has been suggested to underlie rhythmical bursting in Parkinson's disease, we first ..
  56. doi Neuronal activity in the primate globus pallidus during smooth pursuit eye movements
    Atsushi Yoshida
    Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan
    Neuroreport 20:121-5. 2009
    ..To understand whether the basal ganglia, especially the globus pallidus (GP), could play roles in pursuit, we examined the firing of individual GP neurons when monkeys performed ..
  57. ncbi Globus pallidus internus deep brain stimulation for dystonic conditions: a prospective audit
    John Yianni
    Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
    Mov Disord 18:436-42. 2003
    In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured target in the treatment of patients with dystonia...
  58. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  59. ncbi Down-regulation of metabotropic glutamate receptor 1alpha in globus pallidus and substantia nigra of parkinsonian monkeys
    K Kaneda
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Eur J Neurosci 22:3241-54. 2005
    ..but not of other subtypes, was significantly reduced in the internal and external segments of the globus pallidus and the substantia nigra pars reticulata...
  60. pmc Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA
    J Neurophysiol 100:2549-63. 2008
    Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is an effective therapy option for controlling the motor symptoms of medication-refractory Parkinson's disease and dystonia...
  61. ncbi The globus pallidus pars externa and Parkinson's disease. Ready for prime time?
    Jose A Obeso
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
    Exp Neurol 202:1-7. 2006
  62. ncbi Chronic stimulation of the globus pallidus internus for treatment of non-dYT1 generalized dystonia and choreoathetosis: 2-year follow up
    Joachim K Krauss
    Department of Neurology, Inselspital, University of Berne, Switzerland
    J Neurosurg 98:785-92. 2003
    The authors studied the long-term efficacy of deep brain stimulation (DBS) of the posteroventral lateral globus pallidus internus up to 2 years postoperatively in patients with primary non-DYT1 generalized dystonia or choreoathetosis...
  63. pmc Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus
    Jerome Baufreton
    Department of Physiology, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    J Neurophysiol 102:532-45. 2009
    The reciprocally connected GABAergic globus pallidus (GP)-glutamatergic subthalamic nucleus (STN) network is critical for voluntary movement and an important site of dysfunction in movement disorders such as Parkinson's disease...
  64. ncbi Synaptically released GABA activates both pre- and postsynaptic GABA(B) receptors in the rat globus pallidus
    Katsuyuki Kaneda
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA
    J Neurophysiol 94:1104-14. 2005
    The globus pallidus (GP) contains abundant GABAergic synapses and GABA(B) receptors...
  65. pmc The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway
    Salvatore Galati
    Department of Neuroscience, University of Rome Tor Vergata, Roma, Italy
    J Physiol 587:4405-23. 2009
    ..Yet, in 6-hydroxydopamine-lesioned animals, the firing discharge of the globus pallidus (GP) and the substantia nigra reticulata are in phase with urethane-induced slow wave cortical activity...
  66. ncbi Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial
    Joerg Mueller
    Mov Disord 23:131-4. 2008
    ..The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia...
  67. ncbi Functional correlations between neighboring neurons in the primate globus pallidus are weak or nonexistent
    Izhar Bar-Gad
    Center for Neural Computation, The Hebrew University, Jerusalem 91120, Israel
    J Neurosci 23:4012-6. 2003
    ..basal ganglia displays topographical organization and massive funneling of neuronal projections toward the globus pallidus as well as an axonal collateral system within this nucleus...
  68. ncbi Subdyskinetic apomorphine responses in globus pallidus and subthalamus of parkinsonian patients: lack of clear evidence for the 'indirect pathway'
    A Stefani
    Clinica Neurologica, Univ di Tor Vergata, P le Umanesimo 10, 00144 Rome, Italy
    Clin Neurophysiol 113:91-100. 2002
    ..We have challenged this view, based on the so-called 'indirect pathway', by recording apomorphine effects from both structures of parkinsonian patients, at rest and during passive movements...
  69. ncbi Microstimulation-induced inhibition of neuronal firing in human globus pallidus
    J O Dostrovsky
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 84:570-4. 2000
    ..PD) frequently employs chronic high-frequency deep brain stimulation (DBS) within the internal segment of globus pallidus (GPi) and can very effectively reduce L-dopa-induced dyskinesias and bradykinesia, but the mechanisms are ..
  70. doi A computational modelling approach to investigate different targets in deep brain stimulation for Parkinson's disease
    Marco Pirini
    Biomedical Engineering Unit, Department of Electronics, Computer Science and Systems, Universita di Bologna, Viale Risorgimento 2, 40136, Bologna, Italy
    J Comput Neurosci 26:91-107. 2009
    ..DBS) for Parkinson's disease (PD) in different target sites in the subthalamic nucleus (STN), the globus pallidus pars interna (GPi), and the globus pallidus pars externa (GPe)...
  71. ncbi A telencephalic nucleus essential for song learning contains neurons with physiological characteristics of both striatum and globus pallidus
    Michael A Farries
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:3776-87. 2002
    ..in mammalian striatum; instead, this cell type resembles neurons that have been recorded in the mammalian globus pallidus. This pallidum-like cell type morphologically resembles the projection neurons of area X...
  72. ncbi Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease
    Brian H Kopell
    Department of Neurosurgery, Medical College of Wisconsin, and Clement J Zablocki VA Medical Center, Milwaukee, Wisconsin 53202, USA
    Mov Disord 21:S238-46. 2006
    ..The current targets for deep brain stimulation for Parkinson's disease, the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus, will be discussed in the framework of the current ..
  73. ncbi Temporal evolution of oscillations and synchrony in GPi/muscle pairs in Parkinson's disease
    Jose M Hurtado
    Center for Neuroscience, University of California Davis, 1544 Newton Ct, Davis, CA 95616, USA
    J Neurophysiol 93:1569-84. 2005
    ..time-dependent phase correlation techniques were applied to 27 pairs of tremor-related single units in the globus pallidus internus (GPi) and EMG of patients with Parkinson's disease (PD) undergoing stereotactic neurosurgery...
  74. ncbi Pallidal stimulation improves pantothenate kinase-associated neurodegeneration
    Pierre Castelnau
    Pediatric Neurology and Institut National de la Sante et de la Recherche Médicale UB19 Hôpital Gatien de Clocheville, Centre Hospitalo Universitaire, Tours, France 619
    Ann Neurol 57:738-41. 2005
    ..We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement ..
  75. ncbi Distribution of DARPP-32 in the basal ganglia: an electron microscopic study
    C C Ouimet
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    J Neurocytol 19:39-52. 1990
    ..has been studied by light and electron microscopical immunocytochemistry in the rat caudatoputamen, globus pallidus and substantia nigra. In the caudatoputamen, DARPP-32 was present in neurons of the medium-sized spiny type...
  76. ncbi Pallidal deep-brain stimulation in primary generalized or segmental dystonia
    Andreas Kupsch
    Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    N Engl J Med 355:1978-90. 2006
    Neurostimulation of the internal globus pallidus has been shown to be effective in reducing symptoms of primary dystonia. We compared this surgical treatment with sham stimulation in a randomized, controlled clinical trial.
  77. ncbi Balance of monosynaptic excitatory and disynaptic inhibitory responses of the globus pallidus induced after stimulation of the subthalamic nucleus in the monkey
    Hitoshi Kita
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 25:8611-9. 2005
    ..STN) plays a pivotal role in controlling the activity of both the external and internal segments of the globus pallidus (GPe and GPi, respectively)...
  78. pmc Electrophysiological characteristics of globus pallidus neurons
    Jenia Bugaysen
    The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    PLoS ONE 5:e12001. 2010
    Extracellular recordings in primates have identified two types of neurons in the external segment of the globus pallidus (GPE): high frequency pausers (HFP) and low frequency bursters (LFB)...
  79. pmc Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons
    Christopher A Deister
    Department of Biology and Neurosciences Institute, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurosci 29:8452-61. 2009
    b>Globus pallidus (GP) neurons fire rhythmically in the absence of synaptic input, suggesting that they may encode their inputs as changes in the phase of their rhythmic firing...
  80. doi Somatotopic organization in the internal segment of the globus pallidus in Parkinson's disease
    Kenneth B Baker
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Exp Neurol 222:219-25. 2010
    Ablation or deep brain stimulation in the internal segment of the globus pallidus (GPi) is an effective therapy for the treatment of Parkinson's disease (PD)...
  81. ncbi Staged bilateral stereotactic pallidothalamotomy for life-threatening dystonia in a child with Hallervorden-Spatz disease
    Istvan Balas
    Department of Neurosurgery, University of Pecs, Pecs, Hungary
    Mov Disord 21:82-5. 2006
    ..Stereotactic staged bilateral pallidothalamotomy should be considered as a potential treatment in the management of life-threatening generalized dystonia related to HSD...
  82. doi Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity
    Nicolas Mallet
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, UK
    J Neurosci 28:14245-58. 2008
    ..network substrates underlying these exaggerated beta oscillations are unknown but activity in the external globus pallidus (GP), which forms a candidate pacemaker network with STN, might be of particular importance...
  83. ncbi End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation
    Diana Apetauerova
    Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts, USA
    Mov Disord 21:1277-9. 2006
    ..b>Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day ..
  84. ncbi Electrophysiological and behavioral effects of zolpidem in rat globus pallidus
    Lei Chen
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Exp Neurol 186:212-20. 2004
    The globus pallidus is believed to play a critical role in the normal function of the basal ganglia, and abnormal activity of its neurons may underlie some basal ganglia motor symptoms...
  85. pmc Structural analysis of the basal ganglia in schizophrenia
    Daniel Mamah
    Department of Psychiatry, Washington University Medical School, St Louis, MO 63110, USA
    Schizophr Res 89:59-71. 2007
    ..Left and right volumes of the caudate and putamen, as well as the right globus pallidus volume, were significantly increased in subjects with schizophrenia as compared to comparison subjects after ..
  86. ncbi Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration
    Donald C Shields
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Pediatr Neurol 37:442-5. 2007
    ..Pallidal deep-brain stimulation appears to create a functional correction that may alter globus pallidus internus inhibitory output to the motor thalamus...
  87. ncbi Randomized trial of pallidotomy versus medical therapy for Parkinson's disease
    Jerrold L Vitek
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann Neurol 53:558-69. 2003
    ..0001), "off" motor (p < 0.0001) and complications of therapy subscores (p < 0.0001). Sustained improvement was also seen for tremor, rigidity, bradykinesia, percent on time and drug-induced dyskinesias...
  88. ncbi D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    C R Gerfen
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892
    Science 250:1429-32. 1990
    ..disease and show alterations in gene expression in the two major output systems of the striatum to the globus pallidus and substantia nigra...
  89. ncbi Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans
    David Williams
    Sobell Department of Neurophysiology, Institute of Neurology, London, UK
    Brain 125:1558-69. 2002
    ..An EEG was also recorded, as were the signals from MEs in the globus pallidus interna (GPi) in two of the cases...
  90. doi Dopamine inhibits GABA transmission from the globus pallidus to the thalamic reticular nucleus via presynaptic D4 receptors
    D Gasca-Martinez
    Departamento de Farmacologia, CINVESTAV IPN, Apartado Postal 14 740, Mexico D F, 07000, Mexico
    Neuroscience 169:1672-81. 2010
    The globus pallidus sends a significant GABAergic projection to the thalamic reticular nucleus...
  91. ncbi Unrelated course of subthalamic nucleus and globus pallidus neuronal activities across vigilance states in the rat
    N Urbain
    Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, Frnace
    Eur J Neurosci 12:3361-74. 2000
    ..of this pathway across the sleep-wake cycle, single-unit activities of subthalamic nucleus (STN) and globus pallidus (GP) neurons were examined, together with cortical electroencephalogram and nuchal muscular activity, in non-..
  92. pmc Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 152:321-30. 2008
    ..This research may have implications for understanding the brain mechanisms involved in energy-related psychiatric dysfunctions such as psychomotor retardation in depression, anergia, and apathy...
  93. ncbi Evolving metabolic changes during the first postoperative year after subthalamotomy
    Maja Trost
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, USA
    J Neurosurg 99:872-8. 2003
    ..disease (PD) is associated with metabolic alterations in key targets of subthalamic nucleus (STN) and globus pallidus (GP) output...
  94. ncbi Integration and segregation of limbic cortico-striatal loops at the thalamic level: an experimental tracing study in rats
    H J Groenewegen
    Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Department of Anatomy, Faculty of Medicine, Vrije Universiteit, The Netherlands
    J Chem Neuroanat 16:167-85. 1999
    ....
  95. ncbi Temporal parenteral nutrition in children causing t1 shortening in the anterior pituitary gland and globus pallidus
    H Suzuki
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Neuropediatrics 34:200-4. 2003
    ..T (1)-weighted images were obtained to analyze the T (1) shortening in the anterior pituitary gland and globus pallidus. All eight patients receiving PN with TE exhibited T (1) shortening in the anterior pituitary gland (six ..
  96. ncbi Linear T2 hyperintensity along the medial margin of the globus pallidus in patients with Machado-Joseph disease and Parkinson disease, and in healthy subjects
    W Shirai
    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
    AJNR Am J Neuroradiol 28:1993-5. 2007
    Linear hyperintensity along the medial margin of the internal segment of the globus pallidus (GPi) on T2-weighted images from patients with Machado-Joseph disease (MJD) was recently reported...
  97. pmc Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata
    SooYoon Shin
    Department of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurophysiol 103:1874-87. 2010
    ..of the nuclei have high firing rates and inhibitory influences: the substantia nigra pars reticulata (SNr), globus pallidus interna (GPi), and globus pallidus externa (GPe)...
  98. ncbi Comparison of atlas- and magnetic resonance imaging-based stereotactic targeting of the globus pallidus internus in the performance of deep brain stimulation for treatment of dystonia
    Nathalie Vayssiere
    Department of Pediatric Neurosurgery Research Group on Movement Disorders in Children, University Hospital, Montpellier, France
    J Neurosurg 96:673-9. 2002
    ..of relying on atlases during stereotactic neurosurgery, the authors compared target coordinates in the globus pallidus internus (GPi) obtained using magnetic resonance (MR) imaging with those determined using an atlas...
  99. ncbi Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus
    Erwan Bezard
    Basal Gang and CNRS UMR 5543, Universite Victor Segalen, 33076 Bordeaux Cedex, France
    FASEB J 17:2337-8. 2003
    ..As the subthalamic nucleus is overactive in parkinsonism, we suggest that enhancement of sonic hedgehog signaling in the subthalamic nucleus may be of therapeutic value in Parkinson's disease...
  100. doi Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 10:65-9. 2009
    ..Schizophrenics had significantly lower FA values in the bilateral globus pallidus and left thalamus compared to controls, suggesting that schizophrenics might have microstructural ..
  101. ncbi Context dependency in the globus pallidus internal segment during targeted arm movements
    M J Gdowski
    Department of Physiology, Northwestern University Medical Schoool, Chicago, Illinois 60611, USA
    J Neurophysiol 85:998-1004. 2001
    Extracellular discharges from single neurons in the internal segment of the globus pallidus (GPi) were recorded and analyzed for rate changes associated with visually guided forearm rotations to four different targets...

Research Grants85

  1. Basal Ganglia and Higher Cortical Function
    Peter L Strick; Fiscal Year: 2010
    ..GABA antagonist, Bicuculline (BIC) into the associative and limbic territories of the external segment of the globus pallidus (GPe) reversibly evoke abnormal behaviors...
  2. Extrastriatal functions of dopamine
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..evidence that dopamine loss at locations outside of the striatum such as the substantia nigra or the globus pallidus may play a significant role in the development of parkinsonism...
  3. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2010
    ..Therefore, the globus pallidus with its equally high iron and ferritin levels will be added as an internal control...
  4. Basal Ganglia and Higher Cortical Function
    PETER STRICK; Fiscal Year: 2009
    ..GABA antagonist, Bicuculline (BIC) into the associative and limbic territories of the external segment of the globus pallidus (GPe) reversibly evoke abnormal behaviors...
  5. Cortical connections with the limbic territory of the basal ganglia
    Michelle Morrow; Fiscal Year: 2007
    ..of the GABA antagonist, Bicuculline (Bic) into the limbic territory of the external segment of the Globus Pallidus (GPe) evoke abnormal behaviors including excessive grooming, nail biting, and communicative gestures...
  6. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2010
    ..connects the striatum to the output nuclei, while the indirect pathway influences the output nuclei via the globus pallidus and subthalamic nucleus...
  7. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
    ..We will make microinjections of a GABAergic antagonist, bicuculline, into the external segment of the globus pallidus (GPE)...
  8. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2010
    ..rats implanted with multi-electrode arrays in eight brain areas, including striatum, subthalamic nucleus, globus pallidus, motor and sensory cortices, thalamus, and substantia nigra pars compacta...
  9. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 1993
    ..regulation of GABA and glutamate release by dopaminergic and glutamatergic agonists in slices of the striatum-globus pallidus and frontal cortex and by noradrenergic and glutamatergic agonists in hippocampal slices will be determined...
  10. GABA RECEPTORS IN THE THALAMUS
    Yoland Smith; Fiscal Year: 2005
    ..Both the internal globus pallidus (GPi) and the substantia nigra pays reticulata (SNr) provide GABAergic afferents to specific regions of CM/Pf...
  11. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    ..The globus pallidus internus (GPi) occupies a critical position in this circuit since it is the major output structure of the ..
  12. Mechanisms of Manganese Neurotoxicity
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2010
    ..Mn predominantly accumulates in the basal ganglia structures including the globus pallidus and striatum area, but the cellular mechanisms underlying the neurotoxic effect of Mn in these target neurons ..
  13. Mechanisms of Manganese Neurotoxicity
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2010
    ..Mn predominantly accumulates in the basal ganglia structures including the globus pallidus and striatum area, but the cellular mechanisms underlying the neurotoxic effect of Mn in these target neurons ..
  14. GLUTAMATE IN PARKINSONS DISEASE
    J Greenamyre; Fiscal Year: 1999
    ..in overactivity of the glutamatergic pathways from the subthalamic nucleus to the internal segment of the globus pallidus and the substantia nigra par's reticulate, the output nuclei of the basal ganglia...
  15. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..In view of research showing that haloperidol increases extracellular GABA in globus pallidus, and that haloperidol-induced tremulous jaw movements are reduced by pallidal injections of bicuculline, it ..
  16. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
    ..Furthermore, cannabinoid receptor levels in the output nuclei of the basal ganglia, the globus pallidus and the substantia nigra pars reticulata, are the highest in the brain...
  17. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  18. Deep Brain Stimulation in the Parkinsonian Monkey
    JERROLD VITEK; Fiscal Year: 2006
    ..the introduction of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) as a highly effective treatment modality...
  19. Schizophrenia Data and Software Tool Federation using BIRN Infrastructure
    Lei Wang; Fiscal Year: 2009
    ..e., hippocampus, amygdala, thalamus, caudate nucleus, nucleus accumbens, putamen and globus pallidus)...
  20. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..iridium recording and/or stimulating microelectrodes suitable for very long-term implantation into the globus pallidus or the subthalamic nuclei. We will develop two array configurations...
  21. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
    ..PV)-containing neurons was found in a major output nucleus of the basal ganglia, the internal segment of the globus pallidus (GPi), in TS brains as compared to NC subjects. These are inhibitory neurons projecting to the thalamus...
  22. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..PV)-containing neurons was found in a major output nucleus of the basal ganglia, the internal segment of the globus pallidus (GPi), in TS brains as compared to NC subjects. These are inhibitory neurons projecting to the thalamus...
  23. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
    ..PV)-containing neurons was found in a major output nucleus of the basal ganglia, the internal segment of the globus pallidus (GPi), in TS brains as compared to NC subjects. These are inhibitory neurons projecting to the thalamus...
  24. OPIOID GABA INTERACTIONS AND ANTINOCICEPTION
    Alexander Kalyuzhny; Fiscal Year: 2002
    ..In preliminary studies, we have observed that GABA/A receptors in globus pallidus, hippocampus and DRG are co-localized with mu-opioid receptors...