globus pallidus

Summary

Summary: The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.

Top Publications

  1. ncbi Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
  2. ncbi Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
  3. ncbi Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
  4. pmc Dichotomous organization of the external globus pallidus
    Nicolas Mallet
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology and Oxford Parkinson s Disease Centre, University of Oxford, Oxford OX1 3TH, UK
    Neuron 74:1075-86. 2012
  5. ncbi Effective connectivity reveals important roles for both the hyperdirect (fronto-subthalamic) and the indirect (fronto-striatal-pallidal) fronto-basal ganglia pathways during response inhibition
    Sara Jahfari
    Department of Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
    J Neurosci 31:6891-9. 2011
  6. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
  7. ncbi Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial
    Vincent J J Odekerken
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet Neurol 12:37-44. 2013
  8. ncbi Activity patterns in a model for the subthalamopallidal network of the basal ganglia
    D Terman
    Department of Mathematics, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 22:2963-76. 2002
  9. ncbi Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
  10. ncbi Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network
    P J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Neuroscience 106:313-30. 2001

Detail Information

Publications267 found, 100 shown here

  1. ncbi Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..To examine this hypothesis, we looked for correlations in the discharge activity of pairs of neurons in the globus pallidus internus (GPi), globus pallidus externus (GPe), and the substantia nigra pars reticulata (SNr)...
  2. ncbi Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
    ..hyperdirect' pathway conveys powerful excitatory effects from the motor-related cortical areas to the globus pallidus, bypassing the striatum, with shorter conduction time than effects conveyed through the striatum...
  3. ncbi Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
    ..we investigated the effects of STN HFS on neuronal activity of the internal and external segment of the globus pallidus (GPi and GPe, respectively) in two rhesus monkeys rendered parkinsonian by administration of 1-methyl-4-..
  4. pmc Dichotomous organization of the external globus pallidus
    Nicolas Mallet
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology and Oxford Parkinson s Disease Centre, University of Oxford, Oxford OX1 3TH, UK
    Neuron 74:1075-86. 2012
    ..We have defined an analogous division of labor in the external globus pallidus (GPe) of Parkinsonian rats, showing that the distinct temporal activities of two populations of GPe neuron in..
  5. ncbi Effective connectivity reveals important roles for both the hyperdirect (fronto-subthalamic) and the indirect (fronto-striatal-pallidal) fronto-basal ganglia pathways during response inhibition
    Sara Jahfari
    Department of Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
    J Neurosci 31:6891-9. 2011
    ....
  6. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  7. ncbi Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial
    Vincent J J Odekerken
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet Neurol 12:37-44. 2013
    ..We assessed whether globus pallidus pars interna (GPi) deep brain stimulation (DBS) gives greater functional improvement than does subthalamic ..
  8. ncbi Activity patterns in a model for the subthalamopallidal network of the basal ganglia
    D Terman
    Department of Mathematics, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 22:2963-76. 2002
    ..a conductance-based computational network model of the subthalamic nucleus and the external segment of the globus pallidus in the indirect pathway of the basal ganglia...
  9. ncbi Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
    ..We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease...
  10. ncbi Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network
    P J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Neuroscience 106:313-30. 2001
    The subthalamic nucleus-globus pallidus network plays a central role in basal ganglia function and dysfunction...
  11. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    ..The study reported here directly compared the effects of unilateral DBS in subthalamic nucleus (STN) or globus pallidus (GPi) on QoL in 42 non-demented patients with medication-refractory PD...
  12. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
    Chantal Francois
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2055-70. 2004
    ..be induced by microinjections of bicuculline, a GABAergic antagonist, into different parts of the external globus pallidus (GPe) in monkeys...
  13. ncbi Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey
    Marjorie E Anderson
    Department of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurophysiol 89:1150-60. 2003
    The reduction in symptoms of Parkinson's disease produced by high-frequency stimulation (HFS) in the internal globus pallidus (GPi) has been proposed to be due to stimulus-induced inactivation of pallidal neurons and resulting ..
  14. ncbi A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus
    D Plenz
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Nature 400:677-82. 1999
    ..Here we show that the excitatory STN and inhibitory, external globus pallidus (GPe) form a feedback system that engages in synchronized bursting...
  15. pmc The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons
    Pierre Flandin
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158 2611, USA
    J Neurosci 30:2812-23. 2010
    We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele...
  16. ncbi Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network
    Mark D Bevan
    Dept of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
    Trends Neurosci 25:525-31. 2002
    ..processes at the levels of single neurons and neuronal networks in the subthalamic nucleus (STN) and external globus pallidus (GPe) are associated with the operation of the basal ganglia in health and in Parkinson's disease (PD)...
  17. pmc HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:85-92. 2011
    ..that is traceable to the emergence of synchronous, rhythmic spiking in neurons of the external segment of the globus pallidus (GPe). The origins of this pathophysiology are poorly defined for the generation of pacemaking...
  18. ncbi Differential short-term plasticity at convergent inhibitory synapses to the substantia nigra pars reticulata
    William M Connelly
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    J Neurosci 30:14854-61. 2010
    Inhibitory projections from the striatum and globus pallidus converge onto GABAergic projection neurons of the substantia nigra pars reticulata (SNr)...
  19. ncbi Neurologic manifestations in welders with pallidal MRI T1 hyperintensity
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 64:2033-9. 2005
    ..Increased T1 MRI signal in the basal ganglia is a biologic marker of manganese accumulation. Recent studies have associated welding and parkinsonism, but generally without MRI corroboration...
  20. pmc The subthalamic microlesion story in Parkinson's disease: electrode insertion-related motor improvement with relative cortico-subcortical hypoactivation in fMRI
    Robert Jech
    Dept of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
    PLoS ONE 7:e49056. 2012
    ..In addition, the rigidity and axial symptoms score correlated inversely with activation of the putamen and globus pallidus (p<0.0001). One month later, the OFF/UPDRS-III score had returned to the preoperative level (35.8±7...
  21. ncbi A single-cell analysis of intrinsic connectivity in the rat globus pallidus
    Ahmed R Sadek
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, United Kingdom
    J Neurosci 27:6352-62. 2007
    GABAergic neurons of the globus pallidus (GP) play critical roles in basal ganglia function by virtue of their widespread axonal projections to all parts of the basal ganglia. They also possess local axon collaterals...
  22. ncbi Unilateral pallidotomy for Parkinson's disease disrupts ocular fixation
    John D O'Sullivan
    Department of Clinical Neuroscience, St Vincent s Hospital, Fitzroy, 3065 Victoria, Australia
    J Clin Neurosci 10:181-5. 2003
    ..eye movements in patients with Parkinson's disease (PD) undergoing pallidotomy to assess the role of the globus pallidus interna (GPi) in oculomotor control...
  23. ncbi Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mov Disord 21:S259-83. 2006
    ..of how various mapping strategies modify target selection and outcome following subthalamic nucleus (STN), globus pallidus internus (GPi), and ventralis intermedius (Vim) deep brain stimulation...
  24. ncbi Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice
    Kenji Takahashi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Biol Psychiatry 62:148-57. 2007
    ..We attempted to clarify the neuronal circuits underlying the control of PPI of the startle reflex in mice...
  25. pmc Deep brain stimulation of the globus pallidus internus in the parkinsonian primate: local entrainment and suppression of low-frequency oscillations
    Kevin W McCairn
    Department of Neurobiology, University of Pittsburgh, 4047 BST 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 101:1941-60. 2009
    ..seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease...
  26. pmc The globus pallidus sends reward-related signals to the lateral habenula
    Simon Hong
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Neuron 60:720-9. 2008
    As a major output station of the basal ganglia, the globus pallidus internal segment (GPi) projects to the thalamus and brainstem nuclei thereby controlling motor behavior...
  27. ncbi Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    The authors compared the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted ..
  28. ncbi Functional characterization of GABAergic pallidopallidal and striatopallidal synapses in the rat globus pallidus in vitro
    Robert E Sims
    Biomedical Sciences, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Eur J Neurosci 28:2401-8. 2008
    As a central integrator of basal ganglia function, the external segment of the globus pallidus (GP) plays a critical role in the control of voluntary movement...
  29. ncbi Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism
    A Raz
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    J Neurosci 20:8559-71. 2000
    ..hand tremor and simultaneous activity of several neurons in the external and internal segments of the globus pallidus (GPe and GPi) in two vervet monkeys, before and after systemic treatment with 1-methyl-4-phenyl-1,2,3,6-..
  30. ncbi Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
    Bai Yun Zeng
    NDRG, School of Biomedical and Health Sciences, King s College, London, UK
    Neurobiol Dis 40:599-607. 2010
    ..axon varicosities was noted in the dorsal caudate and putamen of MPTP-intoxicated monkeys but not the globus pallidus. In MPTP-intoxicated marmosets that had received chronic levodopa treatment to induce dyskinesia, a further ..
  31. pmc Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidus
    M Desmurget
    Department of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 99:1057-76. 2008
    ..control, we examined the effects of muscimol-induced inactivations in the skeletomotor region of the internal globus pallidus (sGPi) on visually directed reaching...
  32. ncbi Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeys
    Arthur Leblois
    Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Eur J Neurosci 24:1201-8. 2006
    ..been proposed that bradykinesia (motor slowness) is related either to a modification of the activity of the globus pallidus internalis (GPi), the main output structure, or to a loss of spatial selectivity of the extrapyramidal motor ..
  33. ncbi Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study
    G Douaud
    URA CNRS CEA 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91 401 Orsay, and Département de Neurologie, CHU Angers, France
    Neuroimage 32:1562-75. 2006
    ..and automated methods evidenced the dorso-ventral gradient of striatal atrophy, a loss of grey matter in the globus pallidus and the thalamus, and similar correlations between clinical scores and subcortical atrophy...
  34. ncbi Conditions for the generation of beta oscillations in the subthalamic nucleus-globus pallidus network
    Alejo J Nevado Holgado
    Department of Computer Science, University of Bristol, Bristol BS8 1UB, United Kingdom
    J Neurosci 30:12340-52. 2010
    ..observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus pars externa (GPe)...
  35. ncbi Statistical method for detection of phase-locking episodes in neural oscillations
    Jose M Hurtado
    Center for Neuroscience, University of California, Davis, California 95616, USA
    J Neurophysiol 91:1883-98. 2004
    ..Surrogate methods that preserve the temporal structure of the individual phase time series decrease substantially the number of false positives when tested on a pair of independent signals...
  36. ncbi Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease
    Valerie C Anderson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97201, USA
    Arch Neurol 62:554-60. 2005
    Deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) has been reported to relieve motor symptoms and levodopa-induced dyskinesia in patients with advanced Parkinson disease (PD)...
  37. ncbi Effects of apomorphine on subthalamic nucleus and globus pallidus internus neurons in patients with Parkinson's disease
    R Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 86:249-60. 2001
    ..agonist, on the firing activity of neurons in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) in patients with Parkinson's disease (PD)...
  38. pmc Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus-pallidal circuits
    Leonid L Rubchinsky
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 100:14427-32. 2003
    ..The loss of this ability leads to hypokinesia, known PD motor deficits characterized by a slowness or inability to switch between motor programs...
  39. ncbi Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of parkinsonism
    Gali Heimer
    Department of Physiology, the Interdisciplinary Center for Neural Computation and the Eric Roland Center for Neurodegenerative Diseases, The Hebrew University Hadassah Medical School, Jerusalem, 91120 Israel
    J Neurosci 22:7850-5. 2002
    ..After MPTP treatment, firing rates decreased in the external segment of the globus pallidus (GP(e)) and increased in the internal segment (GP(i))...
  40. ncbi Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat
    A Benazzouz
    Laboratoire de Neurobiologie Preclinique, INSERM U 318, CHU Pavillon B, BP 217, 38043, Grenoble, France
    Neuroscience 99:289-95. 2000
    ..6-hydroxydopamine lesions of the substantia nigra pars compacta (90%) or with ibotenic acid lesions of the globus pallidus (79.5%)...
  41. ncbi Short-term depression of synaptic transmission during stimulation in the globus pallidus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
    Yaara Erez
    Gonda Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurosci 29:7797-802. 2009
    High-frequency stimulation (HFS) in the globus pallidus is used to ameliorate clinical symptoms of Parkinson's disease, dystonia, and other disorders...
  42. pmc Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial
    Frances M Weaver
    Hines VA Hospital, Center for Management of Complex Chronic Care, Hines, Illinois 60141, USA
    JAMA 301:63-73. 2009
    ..Deep brain stimulation is an accepted treatment for advanced Parkinson disease (PD), although there are few randomized trials comparing treatments, and most studies exclude older patients...
  43. ncbi Rhythmic bursting in the cortico-subthalamo-pallidal network during spontaneous genetically determined spike and wave discharges
    Jeanne Tamar Paz
    Institut National de la Santé et de la Recherche Médicale U114, Chaire de Neuropharmacologie, Collège de France and U667, 75231 Paris Cedex 05, France
    J Neurosci 25:2092-101. 2005
    ..The repetitive discharges in STN neurons accompanying absence seizures might convey powerful excitation to basal ganglia output nuclei and, consequently, may participate in the control of thalamocortical SWDs...
  44. ncbi MR imaging findings in hepatic encephalopathy
    A Rovira
    Magnetic Resonance Unit, Department of Radiology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    AJNR Am J Neuroradiol 29:1612-21. 2008
    ..It is likely that MR imaging will be increasingly used to evaluate the mechanisms involved in the pathogenesis of HE and to assess the effects of therapeutic measures focused on correcting brain edema in these patients...
  45. ncbi Correlation of brain magnetic resonance imaging changes with pallidal manganese concentrations in rhesus monkeys following subchronic manganese inhalation
    David C Dorman
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709 2137, USA
    Toxicol Sci 92:219-27. 2006
    ..Monkeys exposed to MnSO(4) at > or = 0.06 mg Mn/m(3) developed increased manganese concentrations in the globus pallidus, putamen, olfactory epithelium, olfactory bulb, and cerebellum...
  46. pmc Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations
    S J Hayflick
    Department of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    AJNR Am J Neuroradiol 27:1230-3. 2006
    ..We investigated correlations between brain MR imaging changes, mutation status, and clinical disease features...
  47. pmc Deep brain stimulation entrains local neuronal firing in human globus pallidus internus
    Daniel R Cleary
    Neurological Surgery, MC L 472, Oregon Health and Science Univ, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    J Neurophysiol 109:978-87. 2013
    Deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) relieves the motor symptoms of Parkinson's disease, yet the mechanism of action remains uncertain...
  48. ncbi Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
    ..Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD)...
  49. pmc External globus pallidus stimulation modulates brain connectivity in Huntington's disease
    Noémie Ligot
    Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Cereb Blood Flow Metab 31:41-6. 2011
    ..with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD)...
  50. ncbi Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystonia
    Moran Weinberger
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Clin Neurophysiol 123:358-68. 2012
    Deep brain stimulation in the globus pallidus internus (GPi) is used to alleviate the motor symptoms of both Parkinson's disease (PD) and dystonia...
  51. ncbi Deep brain stimulation of globus pallidus interna, subthalamic nucleus, and pedunculopontine nucleus for Parkinson's disease: which target?
    Kenneth A Follett
    Division of Neurosurgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Parkinsonism Relat Disord 18:S165-7. 2012
    ..Standard DBS targets are globus pallidus interna (GPi) and subthalamic nucleus (STN)...
  52. ncbi Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism
    C Delaville
    Université Bordeaux Segalen, Centre National de la Recherche Scientifique CNRS UMR 5293, Neurodegenerative Diseases Institute, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Neuroscience 202:424-33. 2012
    ..DSP-4)) and serotonin (5-HT) (with 4-chloro-l-phenylalanine (pCPA)) on the neuronal activity of globus pallidus (GP) and substantia nigra pars reticulata (SNr) neurons in the 6-hydroxydopamine (6-OHDA) rat model of PD and ..
  53. ncbi Integration and segregation of limbic cortico-striatal loops at the thalamic level: an experimental tracing study in rats
    H J Groenewegen
    Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Department of Anatomy, Faculty of Medicine, Vrije Universiteit, The Netherlands
    J Chem Neuroanat 16:167-85. 1999
    ....
  54. ncbi Cannabinoid (CB(1)), GABA(A) and GABA(B) receptor subunit changes in the globus pallidus in Huntington's disease
    K L Allen
    Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    J Chem Neuroanat 37:266-81. 2009
    ..These neurons project principally to the globus pallidus (GP) and substantia nigra pars reticulata (SNr)...
  55. ncbi Eye of the tiger-like MRI in parkinsonian variant of multiple system atrophy
    Ming Hong Chang
    Section of Neurology, Taichung Veterans General Hospital, No 160, Chung Kang Road, Section 3, Taichung, 40705 Taiwan
    J Neural Transm 116:861-6. 2009
    ..There have been no reports describing clinical manifestations of MSA-P with imaging abnormalities over globus pallidus. Here, we describe three patients with typical presentations of MSA-P with autonomic dysfunction and ..
  56. ncbi Improved conditions for the generation of beta oscillations in the subthalamic nucleus--globus pallidus network
    Alex Pavlides
    Bristol Centre for Complexity Sciences, Department of Computer Science, University of Bristol, Bristol BS8 1UB, UK
    Eur J Neurosci 36:2229-39. 2012
    ..We investigated the network model composed of the subthalamic nucleus (STN) and globus pallidus (GP) developed by A. Nevado Holgado et al...
  57. ncbi Power fluctuations in beta and gamma frequencies in rat globus pallidus: association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors
    Cyril Dejean
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    J Neurosci 31:6098-107. 2011
    ..interaction is a feature of normal basal ganglia, we recorded local field potential (LFP) from electrodes in globus pallidus (GP) of intact rats...
  58. ncbi Neuronal activity in globus pallidus interna can be synchronized to local field potential activity over 3-12 Hz in patients with dystonia
    Chiung Chu Chen
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WCIN 3BG, UK
    Exp Neurol 202:480-6. 2006
    ..been hypothesized to contribute to dystonia, it is unclear to what extent these LFP oscillations arise in the globus pallidus interna (GPi) and are synchronous with local neuronal discharge...
  59. ncbi Frequency-dependent effects of electrical stimulation in the globus pallidus of dystonia patients
    Liu D Liu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:5-17. 2012
    Deep brain stimulation (DBS) in the globus pallidus internus (GPi) has been shown to improve dystonia, a movement disorder of repetitive twisting movements and postures...
  60. pmc Effect of globus pallidus internus stimulation on neuronal activity in the pedunculopontine tegmental nucleus in the primate model of Parkinson's disease
    Jianyu Zhang
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 233:575-80. 2012
    ..Internal segment of the globus pallidus (GPi) DBS is effective at treating the motor signs associated with PD, however its impact on MRGPA is limited ..
  61. ncbi Site-specific action of L-3,4-dihydroxyphenylalanine in the striatum but not globus pallidus and substantia nigra pars reticulata evokes dyskinetic movements in chronic L-3,4-dihydroxyphenylalanine-treated 6-hydroxydopamine-lesioned rats
    K Buck
    CNS Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Neuroscience 166:355-8. 2010
    ..of L-DOPA, GABA and glutamate to provoke dyskinetic movements in three basal ganglia structures (striatum, globus pallidus (GP) and substantia nigra pars reticulata (SNr)) of chronically L-DOPA-treated, unilaterally 6-..
  62. pmc Weight changes in subthalamic nucleus vs globus pallidus internus deep brain stimulation: results from the COMPARE Parkinson disease deep brain stimulation cohort
    Maren C Locke
    Department of Neurology, University of Florida Movement Disorders Center McKnight Brain Institute, Gainesville, Florida 32611, USA
    Neurosurgery 68:1233-7; discussion 1237-8. 2011
    ..Parkinson's patients, on average, gain weight after deep brain stimulation (DBS)...
  63. pmc Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata
    SooYoon Shin
    Department of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurophysiol 103:1874-87. 2010
    ..of the nuclei have high firing rates and inhibitory influences: the substantia nigra pars reticulata (SNr), globus pallidus interna (GPi), and globus pallidus externa (GPe)...
  64. pmc Effects of dopamine depletion on information flow between the subthalamic nucleus and external globus pallidus
    Ana V Cruz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK
    J Neurophysiol 106:2012-23. 2011
    ..dopamine depletion on directed information flow within and between the subthalamic nucleus (STN) and external globus pallidus (GPe)...
  65. ncbi 5-HT excites globus pallidus neurons by multiple receptor mechanisms
    L Chen
    Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Neuroscience 151:439-51. 2008
    Anatomical and neurochemical studies indicated that the globus pallidus receives serotonergic innervation from raphe nuclei but the membrane effects of 5-HT on globus pallidus neurons are not entirely clear...
  66. ncbi Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Brain 131:460-72. 2008
    ..noted to have features similar to those described in PNLA, including severe atrophy and neuronal loss in the globus pallidus, substantia nigra and subthalamic nucleus, in addition to many axonal spheroids in the globus pallidus and ..
  67. pmc Functional connectivity and integrative properties of globus pallidus neurons
    D Jaeger
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Neuroscience 198:44-53. 2011
    The globus pallidus consists of the external (GPe) and the internal (GPi) segments. The GPe and GPi have different functional roles. The GPe is located centrally within multiple basal ganglia feedforward and feedback connections...
  68. ncbi Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency
    Keith M Erikson
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    J Nutr Biochem 15:335-41. 2004
    ..in the cerebellum and caudate putamen; and increasing manganese concentrations in caudate putamen, globus pallidus and substantia nigra. Furthermore, there was a significant effect of iron deficiency (P < 0...
  69. ncbi Deep brain stimulation of the internal globus pallidus in dystonia: target localisation under general anaesthesia
    M O Pinsker
    Department of Neurosurgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Acta Neurochir (Wien) 151:751-8. 2009
    Deep brain stimulation (DBS) of the internal globus pallidus (Gpi) is an effective therapy for various types of dystonia...
  70. ncbi Therapy-refractory Tourette syndrome: beneficial outcome with globus pallidus internus deep brain stimulation
    Sandra Dehning
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Mov Disord 23:1300-2. 2008
    We report on a female patient with Tourette syndrome and a 12-month follow-up after chronic deep brain stimulation in the globus pallidus internus which resulted in excellent remission of motor and vocal tics.
  71. ncbi An anxiolytic role for CRF receptor type 1 in the globus pallidus
    Yehezkel Sztainberg
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 31:17416-24. 2011
    ..The globus pallidus external (GPe), a main relay center within the basal ganglia that is primarily associated with motor and ..
  72. ncbi Deep brain stimulation for Gilles de la Tourette syndrome: a case series targeting subregions of the globus pallidus internus
    Raul Martínez-Fernández
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 26:1922-30. 2011
    ..describes our experience with patients with severe refractory Gilles de la Tourette syndrome treated with globus pallidus internus deep brain stimulation...
  73. ncbi Temporal convergence of dynamic cell assemblies in the striato-pallidal network
    Avital Adler
    Department of Medical Neuroscience, Institute of Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Neurosci 32:2473-84. 2012
    ..of projection neurons [striatal medium spiny neurons (MSNs), and neurons in the external segment of the globus pallidus (GPe)], and one neuromodulator group [striatal tonically active neurons (TANs)] from behaving monkeys...
  74. ncbi Toward an anatomy of disappointment: reward-related signals from the globus pallidus
    Jeff Wickens
    Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
    Neuron 60:530-1. 2008
    The globus pallidus (internal segment, GPi) is traditionally regarded as part of the motor system...
  75. ncbi High-frequency microstimulation in human globus pallidus and substantia nigra
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Medical Sciences Building Room 3302, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Exp Brain Res 205:251-61. 2010
    ..single current pulses delivered from a nearby microelectrode are sufficient to inhibit firing in the internal globus pallidus for tens of milliseconds...
  76. ncbi Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys
    Yoshihisa Tachibana
    Division of System Neurophysiology, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, Myodaiji, Okazaki 444 8585, Japan
    Eur J Neurosci 27:238-53. 2008
    The internal segment of the globus pallidus (GPi) receives motor-related cortical signals mainly through the striatum, the external segment of the globus pallidus (GPe) and the subthalamic nucleus (STN)...
  77. ncbi Functional correlations between neighboring neurons in the primate globus pallidus are weak or nonexistent
    Izhar Bar-Gad
    Center for Neural Computation, The Hebrew University, Jerusalem 91120, Israel
    J Neurosci 23:4012-6. 2003
    ..basal ganglia displays topographical organization and massive funneling of neuronal projections toward the globus pallidus as well as an axonal collateral system within this nucleus...
  78. ncbi Chronic stimulation of the globus pallidus internus for treatment of non-dYT1 generalized dystonia and choreoathetosis: 2-year follow up
    Joachim K Krauss
    Department of Neurology, Inselspital, University of Berne, Switzerland
    J Neurosurg 98:785-92. 2003
    The authors studied the long-term efficacy of deep brain stimulation (DBS) of the posteroventral lateral globus pallidus internus up to 2 years postoperatively in patients with primary non-DYT1 generalized dystonia or choreoathetosis...
  79. ncbi Down-regulation of metabotropic glutamate receptor 1alpha in globus pallidus and substantia nigra of parkinsonian monkeys
    K Kaneda
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Eur J Neurosci 22:3241-54. 2005
    ..but not of other subtypes, was significantly reduced in the internal and external segments of the globus pallidus and the substantia nigra pars reticulata...
  80. ncbi Synaptically released GABA activates both pre- and postsynaptic GABA(B) receptors in the rat globus pallidus
    Katsuyuki Kaneda
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, TN 38163, USA
    J Neurophysiol 94:1104-14. 2005
    The globus pallidus (GP) contains abundant GABAergic synapses and GABA(B) receptors...
  81. ncbi Globus pallidus internus deep brain stimulation for dystonic conditions: a prospective audit
    John Yianni
    Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom
    Mov Disord 18:436-42. 2003
    In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured target in the treatment of patients with dystonia...
  82. ncbi The globus pallidus pars externa and Parkinson's disease. Ready for prime time?
    Jose A Obeso
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
    Exp Neurol 202:1-7. 2006
  83. pmc Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus
    Jerome Baufreton
    Department of Physiology, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    J Neurophysiol 102:532-45. 2009
    The reciprocally connected GABAergic globus pallidus (GP)-glutamatergic subthalamic nucleus (STN) network is critical for voluntary movement and an important site of dysfunction in movement disorders such as Parkinson's disease...
  84. ncbi Neuronal activity in the primate globus pallidus during smooth pursuit eye movements
    Atsushi Yoshida
    Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan
    Neuroreport 20:121-5. 2009
    ..To understand whether the basal ganglia, especially the globus pallidus (GP), could play roles in pursuit, we examined the firing of individual GP neurons when monkeys performed ..
  85. pmc The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway
    Salvatore Galati
    Department of Neuroscience, University of Rome Tor Vergata, Roma, Italy
    J Physiol 587:4405-23. 2009
    ..Yet, in 6-hydroxydopamine-lesioned animals, the firing discharge of the globus pallidus (GP) and the substantia nigra reticulata are in phase with urethane-induced slow wave cortical activity...
  86. ncbi Neostriatal and globus pallidus stimulation induced inhibitory postsynaptic potentials in entopeduncular neurons in rat brain slice preparations
    H Kita
    Department of Anatomy and Neurobiology, The University of Tennessee Memphis, 855 Monroe Avenue, Memphis, TN 38163, USA
    Neuroscience 105:871-9. 2001
    ..that the entopeduncular nucleus of the rat receives GABAergic inputs from both the neostriatum and the globus pallidus. The present study was undertaken to reveal the physiological features of these inputs using the ..
  87. pmc Quantifying the neural elements activated and inhibited by globus pallidus deep brain stimulation
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA
    J Neurophysiol 100:2549-63. 2008
    Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is an effective therapy option for controlling the motor symptoms of medication-refractory Parkinson's disease and dystonia...
  88. pmc Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration
    Nathan W Schultheiss
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 30:2767-82. 2010
    Synchronization of globus pallidus (GP) neurons and cortically entrained oscillations between GP and other basal ganglia nuclei are key features of the pathophysiology of Parkinson's disease...
  89. ncbi Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial
    Joerg Mueller
    Mov Disord 23:131-4. 2008
    ..The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia...
  90. ncbi Subdyskinetic apomorphine responses in globus pallidus and subthalamus of parkinsonian patients: lack of clear evidence for the 'indirect pathway'
    A Stefani
    Clinica Neurologica, Univ di Tor Vergata, P le Umanesimo 10, 00144 Rome, Italy
    Clin Neurophysiol 113:91-100. 2002
    ..We have challenged this view, based on the so-called 'indirect pathway', by recording apomorphine effects from both structures of parkinsonian patients, at rest and during passive movements...
  91. ncbi Globus pallidus internal segment
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    Prog Brain Res 160:135-50. 2007
    The internal segment of the globus pallidus (GP(i)) gathers many bits of information including movement-related activity from the striatum, external segment of the globus pallidus (GP(e)), and subthalamic nucleus (STN), and integrates ..
  92. ncbi Statistical properties of pauses of the high-frequency discharge neurons in the external segment of the globus pallidus
    Shlomo Elias
    Department of Physiology, The Hebrew University Hadassah Medical School, 91120 Jerusalem, Israel
    J Neurosci 27:2525-38. 2007
    The neurons of many basal ganglia nuclei, including the external and internal globus pallidus (GPe and GPi, respectively) and the substantia nigra pars reticulata (SNr) are characterized by their high-frequency (50-100 spikes/s) tonic ..
  93. ncbi Short-term plasticity shapes the response to simulated normal and parkinsonian input patterns in the globus pallidus
    Jesse E Hanson
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:5164-72. 2002
    ..To determine the role of STP in the subthalamic nucleus (STN) to globus pallidus (GP) connection, which has been suggested to underlie rhythmical bursting in Parkinson's disease, we first ..
  94. ncbi Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans
    David Williams
    Sobell Department of Neurophysiology, Institute of Neurology, London, UK
    Brain 125:1558-69. 2002
    ..An EEG was also recorded, as were the signals from MEs in the globus pallidus interna (GPi) in two of the cases...
  95. pmc Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons
    Christopher A Deister
    Department of Biology and Neurosciences Institute, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Neurosci 29:8452-61. 2009
    b>Globus pallidus (GP) neurons fire rhythmically in the absence of synaptic input, suggesting that they may encode their inputs as changes in the phase of their rhythmic firing...
  96. ncbi Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus
    Xiao Tao Jin
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Eur J Neurosci 33:1504-18. 2011
    ..the respective roles of these transporters in regulating evoked inhibitory postsynaptic currents (eIPSCs) in globus pallidus (GP) neurons after striatal stimulation...
  97. ncbi Enhanced modulation of neuronal activity during antisaccades in the primate globus pallidus
    Atsushi Yoshida
    Department of Physiology, Hokkaido University School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Cereb Cortex 19:206-17. 2009
    ..Recent imaging studies suggest that the globus pallidus (GP) is involved in the generation of antisaccades...
  98. ncbi A computational modelling approach to investigate different targets in deep brain stimulation for Parkinson's disease
    Marco Pirini
    Biomedical Engineering Unit, Department of Electronics, Computer Science and Systems, Universita di Bologna, Viale Risorgimento 2, 40136, Bologna, Italy
    J Comput Neurosci 26:91-107. 2009
    ..DBS) for Parkinson's disease (PD) in different target sites in the subthalamic nucleus (STN), the globus pallidus pars interna (GPi), and the globus pallidus pars externa (GPe)...
  99. ncbi A telencephalic nucleus essential for song learning contains neurons with physiological characteristics of both striatum and globus pallidus
    Michael A Farries
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:3776-87. 2002
    ..in mammalian striatum; instead, this cell type resembles neurons that have been recorded in the mammalian globus pallidus. This pallidum-like cell type morphologically resembles the projection neurons of area X...
  100. ncbi Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson's disease
    Brian H Kopell
    Department of Neurosurgery, Medical College of Wisconsin, and Clement J Zablocki VA Medical Center, Milwaukee, Wisconsin 53202, USA
    Mov Disord 21:S238-46. 2006
    ..The current targets for deep brain stimulation for Parkinson's disease, the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus, will be discussed in the framework of the current ..
  101. ncbi Temporal evolution of oscillations and synchrony in GPi/muscle pairs in Parkinson's disease
    Jose M Hurtado
    Center for Neuroscience, University of California Davis, 1544 Newton Ct, Davis, CA 95616, USA
    J Neurophysiol 93:1569-84. 2005
    ..time-dependent phase correlation techniques were applied to 27 pairs of tremor-related single units in the globus pallidus internus (GPi) and EMG of patients with Parkinson's disease (PD) undergoing stereotactic neurosurgery...

Research Grants66

  1. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    ..Therefore, the globus pallidus with its equally high iron and ferritin levels will be added as an internal control...
  2. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..and MRI examinations of these patients have consistently revealed lesions in the basal ganglia, including the globus pallidus and putamen. Damage in the human brain has been confirmed via autopsy...
  3. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..and pedunculopontine pathway system, and compare neuropathology of caudate, putamen, globus pallidus, thalamus substantia nigra and brainstem especially superior coliculus and dorsal pons varolii of Myoclonin1/..
  4. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, amygdala and fronto-cortical regions (cingulate and subgenual cortical areas) as well as ..
  5. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..in subregions of the striatum/BG in Gng7 knockout mice, including caudate-putamen, nucleus accumbens and globus pallidus, as well as other CB1 and D2 containing regions such as prefrontal cortex and hippocampus...
  6. Role of Parkin in Regulating Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010
    ..components within the basal ganglia as a disturbance in any one of the elements, whether it occurs in the globus pallidus as in manganism or the nigro-striatal neurons as in Parkinson's disease, manifests in insidious ..
  7. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..rats implanted with multi-electrode arrays in eight brain areas, including striatum, subthalamic nucleus, globus pallidus, motor and sensory cortices, thalamus, and substantia nigra pars compacta...
  8. Effect of Manganese Exposure on GABA and Glutamate in Human Brains by MRS
    Ulrike Dydak; Fiscal Year: 2010
    ..the pallidal brain region, and (2) such changes, together with the known MRI signal intensity increase in the globus pallidus due to Mn deposition in this brain region, correlate with the extent of Mn exposure, as measured by other ..
  9. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ..such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that Parkinson's disease is a network disorder, involving alteration of the ..
  10. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013
    ..connects the striatum to the output nuclei, while the indirect pathway influences the output nuclei via the globus pallidus and subthalamic nucleus...
  11. Role of inflammation in manganese neurotoxicity: molecular mechanisms
    Nikolay M Filipov; Fiscal Year: 2010
    ..The project has the following Specific Aims: 1) determine, in a time-, brain region (striatum, globus pallidus, thalamus, substantia nigra)-, concentration-, and route of exposure- dependent fashion, the molecular ..
  12. Serotonin 1B Receptor Imaging in Major Depressive Disorder
    Alexander Neumeister; Fiscal Year: 2010
    ..Highest concentrations of 5-HT1B receptors are found in the globus pallidus in humans...
  13. Basal Ganglia and Higher Cortical Function
    Peter L Strick; Fiscal Year: 2012
    ..GABA antagonist, Bicuculline (BIC) into the associative and limbic territories of the external segment of the globus pallidus (GPe) reversibly evoke abnormal behaviors...
  14. Organization and Function of Striatal Microcircuits in Health and Disease
    ARYN HILARY GITTIS; Fiscal Year: 2013
    ..In Aim 3, I will turn to FS inputs from the globus pallidus (GPe);although inputs from the GPe were identified anatomically over ten years ago, a detailed functional ..
  15. Organization and Function of Striatal Microcircuits in Health and Disease
    ARYN HILARY GITTIS; Fiscal Year: 2012
    ..In Aim 3, I will turn to FS inputs from the globus pallidus (GPe);although inputs from the GPe were identified anatomically over ten years ago, a detailed functional ..
  16. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    ..The areas stimulated will be the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi), two structures now used to treat idiopathic PD in patients...
  17. Regional Brain Manganese Accumulation and Functional Consequences in Welders
    Xuemei Huang; Fiscal Year: 2013
    ..Its utility has been questioned because regions other than the globus pallidus (GP) have been neglected for study, and the pallidal index may not be sensitive to low levels of exposure...
  18. NEUROPATHOLOGY OF CHRONIC MANGANESE EXPOSURE
    Brad A Racette; Fiscal Year: 2010
    ..staining with antibodies against NeuN, GFAP and CD68, in the following fixed brain regions: globus pallidus interna, substantia nigra pars compacta, locus ceruleus, and olfactory bulb...
  19. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2013
    ..of the medial ganglionic eminence (MGE);it produces GABAergic and cholinergic projection neurons of the globus pallidus, nucleus basalis and adjacent regions, and GABAergic and cholinergic interneurons that disperse throughout ..
  20. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an effective therapy for the treatment of this disorder producing ..
  21. Basal ganglia-thalamic signaling in parkinsonism and deep brain stimulation
    ROBERT STERLING TURNER; Fiscal Year: 2013
    ..disease (PD) have been linked causally to abnormalities in the spiking activity of neurons in the globus pallidus internus (GPi), a major output nucleus of the basal ganglia (BG)...
  22. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..PV)-containing neurons was found in a major output nucleus of the basal ganglia, the internal segment of the globus pallidus (GPi), in TS brains as compared to NC subjects. These are inhibitory neurons projecting to the thalamus...
  23. Synaptic Transmission, Plasticity and Integration in the Subthalamic Nucleus
    Mark D Bevan; Fiscal Year: 2013
    ..to changes in the frequency and pattern of neuronal activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) and associated cortico-basal ganglia-thalamocortical ..
  24. Cerebellar stimulation for the treatment of dystonia: preclinical studies
    Ellen J Hess; Fiscal Year: 2013
    ..Deep brain stimulation (DBS) of the internal globus pallidus is another treatment option...
  25. Basal Ganglia Functions in Huntington's Disease: Genetic Mouse Models
    Elizabeth D Abercrombie; Fiscal Year: 2012
    ..Physiological studies of other sites in the basal ganglia (globus pallidus, subthalamic nucleus) will reveal potential "downstream" alterations in the circuitry...
  26. Pathophysiology of Dystonia
    Mark S Baron; Fiscal Year: 2013
    ..movement-related alterations in neuronal discharge activity in basal ganglia nuclei, including pauses in the globus pallidus (GP) and bursts in the entopeduncular nucleus (EP) in dystonic Gunn rats...
  27. Mitochondrial Role in Manganese Toxicity
    Thomas Gunter; Fiscal Year: 2010
    ..In the cells of its target brain tissue, primarily neurons of the globus pallidus and striatum, Mn is sequestered by the mitochondria...
  28. Rhythmicity and Synchrony in the Basal Ganglia
    DALTON JAMES SURMEIER; Fiscal Year: 2013
    ..Savio Chan, pursues the mechanisms governing the emergence of synchronous rhythmic bursting in globus pallidus neurons in Parkinson's disease, focusing on a novel class of these neurons that project to the striatum...
  29. Neural Interactions Among Multiple Motor Structures
    Marc H Schieber; Fiscal Year: 2010
    ..Project 4, Basal Ganglia - Cortical Interactions in Motor Control (Mink, PI) asks how interactions of the globus pallidus, pars interna, with the primary motor cortex and the supplementary motor area, suppress posture and permit ..
  30. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
    ..The new striatal neurons project to the globus pallidus and adopt a DARPP32/GABAergic/calbindin+ phenotype, characteristic of medium spiny projection neurons...
  31. Concurrent PET D2/D3 receptor imaging and fMRI smoking cue reactivity in smokers
    Marc J Kaufman; Fiscal Year: 2013
    ..11C]-(+)-PHNO binding in brain regions involved in reward learning including the substantia nigra (SN), globus pallidus (GP), and ventral pallidum (VP)...
  32. Behavioral and Neuroanatomical Characterization of a Novel Genetic Animal Model o
    PATRICK JOHN SCHULTHEIS; Fiscal Year: 2010
    ..analyses to identify alterations in brain neuroanatomy with emphasis placed on the substantia nigra (SN) and globus pallidus (GP), regions known to be affected in sporadic PD and KuforRakeb syndrome, respectively...
  33. Extrastriatal functions of dopamine
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..evidence that dopamine loss at locations outside of the striatum such as the substantia nigra or the globus pallidus may play a significant role in the development of parkinsonism...
  34. STN Stimulation: Neural Control of Movement and Posture
    DANIEL MONTIE CORCOS; Fiscal Year: 2011
    ..a powerful influence over two nuclei that regulate eye (substantia nigra pars reticulata (SNpr)) and limb (globus pallidus internus (GPi)) motor control...
  35. Striatal Microcircuits: Regulation and Function
    Anatol Kreitzer; Fiscal Year: 2013
    ..Aim 1 examines how distinct inputs from cortex, thalamus, and globus pallidus influence FSI firing patterns, both spontaneously and at critical moments of choice task performance...
  36. Neostriatum in Learning and Memory
    Emad N Eskandar; Fiscal Year: 2013
    ..provided by applicant): During the previous funding period we began studying learning in the caudate and the globus pallidus internus...
  37. Pathophysiology of Transgenic Mouse Models of Huntington's Disease
    Michael S Levine; Fiscal Year: 2013
    ..These will affect their targets in globus pallidus and substantia nigra...
  38. Cortical connections with the limbic territory of the basal ganglia
    Michelle Morrow; Fiscal Year: 2007
    ..of the GABA antagonist, Bicuculline (Bic) into the limbic territory of the external segment of the Globus Pallidus (GPe) evoke abnormal behaviors including excessive grooming, nail biting, and communicative gestures...
  39. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
    ..We will make microinjections of a GABAergic antagonist, bicuculline, into the external segment of the globus pallidus (GPE)...
  40. SYNAPTIC MECHANISMS OF THE GLOBUS PALLIDUS
    RONALD HUFFMAN; Fiscal Year: 1980
    ..The responsiveness of primate globus pallidus neurons to microiontophoretically applied putative inhibitory neurotransmitters lambda-aminobutyric acid (..
  41. Supersensitive dopamine D2 receptor inhibition of the striatopallidal projection
    Fu Ming Zhou; Fiscal Year: 2013
    ..D2R)-expressing medium spiny neurons (D2-MSN) in the striatum project to the GABAergic neurons in the globus pallidus (GP), forming an important link in the basal ganglia motor control circuit...
  42. Neurophysiological mechanisms underlying parkinsonian motor signs
    Jerrold L Vitek; Fiscal Year: 2012
    ..Structures that will be examined include the internal and external segments of the globus pallidus (GPi and GPe, respectively), the subthalamic nucleus (STN), and the motor thalamus including ventralis ..
  43. Basal Ganglia Shape Analysis and Circuitry in Huntington's Disease
    Christopher A Ross; Fiscal Year: 2013
    ..We hypothesize that regional globus pallidus atrophy will correlate with specific local basal ganglia connections, but that regional striatal atrophy will ..
  44. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    ..The globus pallidus internus (GPi) occupies a critical position in this circuit since it is the major output structure of the ..
  45. In vivo characterization of the basal ganglia indirect pathway
    DEWAN SYED ADNAN MAJID; Fiscal Year: 2013
    ..The Indirect Pathway refers to projections from the striatum to the external globus pallidus (GPe), which continue to the internal globus pallidus (GPi)...
  46. Mechanism and Treatment of Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010
    ..Manganism, however, is associated with the preferential degeneration of GABAminergic neurons within the globus pallidus and not the dopaminergic neurons in the substantia nigra...
  47. FMRI Study of the Effects of DBS in Primary Generalized Dystonia (K23)
    Benjamin L Walter; Fiscal Year: 2010
    ..associated with the symptomatic improvement in PGD as a result of stimulation in the internal segment of the globus pallidus (GPi)...
  48. NEURONAL PATHWAYS OF THE BASAL GANGLIA
    Hitoshi Kita; Fiscal Year: 2000
    ..The second specific aim is to test my hypothesis that the globus pallidus is the control center of the basal ganglia in that the globus pallidus converges inputs from the neostriatum ..
  49. Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2013
    ..Similarly, the effects of DBS in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) on neuronal activity in the MC and SMA are largely unknown...
  50. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..In view of research showing that haloperidol increases extracellular GABA in globus pallidus, and that haloperidol-induced tremulous jaw movements are reduced by pallidal injections of bicuculline, it ..
  51. STREP, HOST FACTORS, AUTOANTIBODIES & TOURETTE SYNDROME
    Harvey Singer; Fiscal Year: 2000
    ..for TS, our preliminary studies showed that a) serum antibodies to human putamen, but not to caudate or globus pallidus, are significantly increased in children with TS and b) after intrastriatal injection of purified serum IgG ..
  52. MOTOR FUNCTIONS AND FIBER CONNECTIONS OF PALLIDUM
    SAMUEL LILES; Fiscal Year: 1990
    ..the proposed research is to gain important information about neural mechanisms of control of movement by the globus pallidus. Recent anatomical and physiological data indicate that the globus pallidus represents the final integration ..
  53. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
    ..Furthermore, cannabinoid receptor levels in the output nuclei of the basal ganglia, the globus pallidus and the substantia nigra pars reticulata, are the highest in the brain...
  54. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  55. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..iridium recording and/or stimulating microelectrodes suitable for very long-term implantation into the globus pallidus or the subthalamic nuclei. We will develop two array configurations...
  56. CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBS
    WENDY LOMBARDI; Fiscal Year: 2003
    ..the cortical activation on fMRI resulting from stimulation of discrete regions of the subthalamic nucleus and globus pallidus internus, (2) that stimulation of discrete regions of these two nuclei selectively affects cognitive or motor ..
  57. OPIOID GABA INTERACTIONS AND ANTINOCICEPTION
    Alexander Kalyuzhny; Fiscal Year: 2002
    ..In preliminary studies, we have observed that GABA/A receptors in globus pallidus, hippocampus and DRG are co-localized with mu-opioid receptors...
  58. HIGH FIELD MRI IN PARKINSONS DISEASE
    Jay Gorell; Fiscal Year: 1999
    ..g., putamen [PUT] or globus pallidus [GP] in PD, has not been defined in living human subjects. This is because earlier MRI studies at 1...
  59. BASAL GANGLIA GABA-DOPAMINE INTERACTIONS
    James Bennett; Fiscal Year: 1990
    ..Neurophysiological evidence suggests that striatal output through the globus pallidus and nigra is mediated by a series of inhibitory neuronal synapses which use GABA as the neurotransmitter...
  60. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, ..
  61. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor symptoms...
  62. GLUTAMATE IN PARKINSON'S DISEASE
    J Greenamyre; Fiscal Year: 2003
    ..For example, the glutamatergic pathways from subthalamic nucleus to the internal segment of globus pallidus and the substantia nigra pars reticulata become overactive after nigrostriatal dopamine depletion...
  63. SUBSTANTIA NIGRA IN MOVEMENT AND MOVEMENT DISORDERS
    Thomas Wichmann; Fiscal Year: 2000
    ..The neuronal activity in the motor portion of one of these output nuclei, the internal segment of the globus pallidus (GP), has been characterized in detail in intact and Parkinsonian animals...
  64. Role of Manganese in Neurodegenrative Disease
    Donald Smith; Fiscal Year: 2005
    ..depletion of striatal dopamine, whereas non-human primate studies have more commonly shown gliosis in the globus pallidus. Also, most studies have utilized relatively high Mn exposures, while only a few have investigated the ..
  65. CHARACTERIZATION OF A NEURON-SPECIFIC PHOSPHOPROTEIN
    Samuel Gandy; Fiscal Year: 1990
    ..Huntington's disease (caudate), Parkinson's disease (substantia nigra), and the dystonias (putamen and globus pallidus)...
  66. DEEP BRAIN STIMULATION FOR PARKINSONS DISEASE
    JERROLD VITEK; Fiscal Year: 2005
    ..out a prospective, randomized clinical trial of deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) for the treatment of advanced Parkinson's disease (PD)...