Genomes and Genes
Summary: Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.
Publications348 found, 100 shown here
- Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitryAlexxai V Kravitz
Gladstone Institute of Neurological Disease, 1650 Owens St, San Francisco, California 94158, USA
Nature 466:622-6. 2010Neural circuits of the basal ganglia are critical for motor planning and action selection. Two parallel basal ganglia pathways have been described, and have been proposed to exert opposing influences on motor function...
- Dissociable roles of ventral and dorsal striatum in instrumental conditioningJohn O'Doherty
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
Science 304:452-4. 2004..Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor...
- The role of the basal ganglia in habit formationHenry H Yin
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, TS 13, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 7:464-76. 2006..How are goal-directed actions transformed into habitual responses? Recent work combining modern behavioural assays and neurobiological analysis of the basal ganglia has begun to yield insights into the neural basis of habit formation.
- Pathological synchronization in Parkinson's disease: networks, models and treatmentsConstance Hammond
Institut de Neurobiologie de la Mediterranee, U29 INSERM, Université Aix Marseille II and UMR CNRS 5543, Universite Bordeaux 2, France
Trends Neurosci 30:357-64. 2007..Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop...
- Functional connectivity of human striatum: a resting state FMRI studyA Di Martino
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
Cereb Cortex 18:2735-47. 2008Classically regarded as motor structures, the basal ganglia subserve a wide range of functions, including motor, cognitive, motivational, and emotional processes...
- Evidence for segregated and integrative connectivity patterns in the human Basal GangliaBogdan Draganski
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
J Neurosci 28:7143-52. 2008Detailed knowledge of the anatomy and connectivity pattern of cortico-basal ganglia circuits is essential to an understanding of abnormal cortical function and pathophysiology associated with a wide range of neurological and ..
- Neural representation of time in cortico-basal ganglia circuitsDezhe Z Jin
Department of Physics, Pennsylvania State University, 104 Davey Laboratory, PMB 206, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 106:19156-61. 2009..We searched for time representations in cortico-basal ganglia circuits by recording from thousands of neurons in the prefrontal cortex and striatum of macaque monkeys ..
- The cortico-basal ganglia integrative network: the role of the thalamusSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA suzanne
Brain Res Bull 78:69-74. 2009The thalamus is a critical component of the frontal cortical-basal ganglia-thalamic circuits that mediate motivation and emotional drive, planning and cognition for the development and expression of goal-directed behaviors...
- Cortico-Basal Ganglia reward network: microcircuitrySusan R Sesack
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 35:27-47. 2010..A fuller appreciation of the circuitry interconnecting the nucleus accumbens and ventral tegmental area should serve to advance discovery of new treatment options for these conditions...
- The primate basal ganglia: parallel and integrative networksSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Chem Neuroanat 26:317-30. 2003The basal ganglia and frontal cortex operate together to execute goal directed behaviors...
- Goal-directed and habitual control in the basal ganglia: implications for Parkinson's diseasePeter Redgrave
Neuroscience Research Unit, Department of Psychology, University of Sheffield, UK
Nat Rev Neurosci 11:760-72. 2010Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease...
- Striatal plasticity and basal ganglia circuit functionAnatol C Kreitzer
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Neuron 60:543-54. 2008The dorsal striatum, which consists of the caudate and putamen, is the gateway to the basal ganglia. It receives convergent excitatory afferents from cortex and thalamus and forms the origin of the direct and indirect pathways, which are ..
- Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonismAgnieszka Jazwa
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain
Antioxid Redox Signal 14:2347-60. 2011..administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone ..
- Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selectionMarcus Stephenson-Jones
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Curr Biol 21:1081-91. 2011Although the basal ganglia are thought to play a key role in action selection in mammals, it is unknown whether this mammalian circuitry is present in lower vertebrates as a conserved selection mechanism...
- Making working memory work: a computational model of learning in the prefrontal cortex and basal gangliaRandall C O'Reilly
Department of Psychology, University of Colorado Boulder, Boulder, CO 80309, USA
Neural Comput 18:283-328. 2006..These learning mechanisms are based on subcortical structures in the midbrain, basal ganglia, and amygdala, which together form an actor-critic architecture...
- Synaptic organisation of the basal gangliaJ P Bolam
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, UK
J Anat 196:527-42. 2000The basal ganglia are a group of subcortical nuclei involved in a variety of processes including motor, cognitive and mnemonic functions...
- Actor-critic models of the basal ganglia: new anatomical and computational perspectivesDaphna Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
Neural Netw 15:535-47. 2002A large number of computational models of information processing in the basal ganglia have been developed in recent years...
- Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brainJuliana Yacubian
Department of Systems Neuroscience, NeuroImage Nord, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
J Neurosci 26:9530-7. 2006..Prevalence of either part might render expectations more positive or negative, which could contribute to the pathophysiology of mood disorders like major depression...
- Role of the basal ganglia in the control of purposive saccadic eye movementsO Hikosaka
Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
Physiol Rev 80:953-78. 2000In addition to their well-known role in skeletal movements, the basal ganglia control saccadic eye movements (saccades) by means of their connection to the superior colliculus (SC)...
- A humanized version of Foxp2 affects cortico-basal ganglia circuits in miceWolfgang Enard
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Cell 137:961-71. 2009..behavior and decreased dopamine concentrations in the brain suggesting that the humanized Foxp2 allele affects basal ganglia. In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional ..
- Distinct basal ganglia territories are engaged in early and advanced motor sequence learningStephane Lehericy
Center for Magnetic Resonance Research Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 102:12566-71. 2005..study, we used functional MRI (fMRI) at high field (3T) to track the time course of activation in the entire basal ganglia circuitry, as well as other motor-related structures, during the explicit learning of a sequence of finger ..
- A computational model of action selection in the basal ganglia. I. A new functional anatomyK Gurney
Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Biol Cybern 84:401-10. 2001We present a biologically plausible model of processing intrinsic to the basal ganglia based on the computational premise that action selection is a primary role of these central brain structures...
- Functional properties of the basal ganglia's re-entrant loop architecture: selection and reinforcementP Redgrave
Neuroscience Research Unit, Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Neuroscience 198:138-51. 2011..In this review we will argue that the re-entrant looped architecture of the basal ganglia represents biological solutions to these fundamental behavioural problems of selection and reinforcement...
- Movement-related changes in synchronization in the human basal gangliaMichael Cassidy
Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, UK
Brain 125:1235-46. 2002There is a wealth of data suggesting that behavioural events are reflected in the basal ganglia through phasic changes in the discharge of individual neurones...
- The basal ganglia: learning new tricks and loving itAnn M Graybiel
Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46 6133, Cambridge, MA, 02139 USA
Curr Opin Neurobiol 15:638-44. 2005The field of basal ganglia research is exploding on every level - from discoveries at the molecular level to those based on human brain imaging...
- Competition between feedback loops underlies normal and pathological dynamics in the basal gangliaArthur Leblois
Laboratoire de Neurophysique et Physiologie du Système Moteur, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8119, Universite Rene Descartes, 75270 Paris, France
J Neurosci 26:3567-83. 2006Experiments performed in normal animals suggest that the basal ganglia (BG) are crucial in motor program selection. BG are also involved in movement disorders...
- Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publicationsRonald B Postuma
Montreal Neurological Institute, Montreal General Hospital, McGill University, 3801 University Street Montreal, Quebec H3A 2B4, Canada
Cereb Cortex 16:1508-21. 2006..The rostrocaudal and dorsoventral patterns of corticostriatal functional connectivity are consistent with the tripartite division of the striatum into motor, associative, and limbic zones...
- Prefrontal cortex and basal ganglia control access to working memoryFiona McNab
Developmental Cognitive Neuroscience, Stockholm Brain Institute, Karolinska Institutet, MR Centrum, Stockholm, Sweden
Nat Neurosci 11:103-7. 2008..Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, ..
- Circuits and circuit disorders of the basal gangliaMahlon R Delong
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Arch Neurol 64:20-4. 2007Views of the anatomy and function of the basal ganglia and their role in motor and nonmotor disorders have undergone major revisions during the past decades...
- Temporal processing in the basal gangliaD L Harrington
Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA
Neuropsychology 12:3-12. 1998This study investigated the role of the basal ganglia in timing operations...
- A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRIBrian Knutson
Department of Psychology, Building 420, Jordan Hall, Stanford University, Stanford, CA 94305 2130, USA
Neuroimage 18:263-72. 2003..00 win, MPFC activity decreased, relative to outcomes with no incentive value. These findings suggest that in the context of processing monetary rewards, a region of the MPFC preferentially tracks rewarding outcomes...
- Contributions of the basal ganglia and functionally related brain structures to motor learningJulien Doyon
Functional Neuroimaging Unit, University of Montreal Geriatric Institute, Montreal, Quebec, Canada
Behav Brain Res 199:61-75. 2009..These results are then put into a plausible neurobiological model of motor skill learning, which proposes an integrated view of the brain plasticity mediating this form of memory at different stages of the acquisition process...
- Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated ParkinsonismMichael J Frank
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, CO 80309, USA
J Cogn Neurosci 17:51-72. 2005Dopamine (DA) depletion in the basal ganglia (BG) of Parkinson's patients gives rise to both frontal-like and implicit learning impairments...
- The basal ganglia communicate with the cerebellumAndreea C Bostan
Department of Neurobiology, University of Pittsburgh School of Medicine, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 107:8452-6. 2010The basal ganglia and cerebellum are major subcortical structures that influence not only movement, but putatively also cognition and affect. Both structures receive input from and send output to the cerebral cortex...
- The neural representation of timeRichard B Ivry
3210 Tolman Hall, Department of Psychology, University of California, Berkeley, California 94720 1650 USA
Curr Opin Neurobiol 14:225-32. 2004..Emphasis has also been placed on the basal ganglia as a specialized timing system, particularly for longer intervals...
- Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's diseasePeter Brown
Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 18:357-63. 2003Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges between neurones...
- Basal ganglia orient eyes to rewardOkihide Hikosaka
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Neurophysiol 95:567-84. 2006..Recent studies suggest an important role of the basal ganglia. Sensorimotor/cognitive activities of neurons in the basal ganglia are strongly modulated by expected reward...
- Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuitsMathias Pessiglione
Laboratoire de neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale Unité 679, Hopital de la Salpetriere, 75651 Paris, France
J Neurosci 25:1523-31. 2005..firing rate and bursty firing pattern, and assumes that dopamine depletion results in a hyperactivity of basal ganglia (BG) output structures...
- Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behaviorLuc Mallet
Institut National de la Santé et de la Recherche Médicale AVENIR Group, Behavior, Emotion, and Basal Ganglia, 75013 Paris, France
Proc Natl Acad Sci U S A 104:10661-6. 2007....
- Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's diseaseCatherine R G Jones
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
Brain Cogn 68:30-41. 2008..in the timing literature is that temporal processing in the milliseconds and seconds range engages the basal ganglia and is modulated by dopamine...
- The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and rewardMark D Humphries
Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, S10 2TN, UK
Prog Neurobiol 90:385-417. 2010The basal ganglia are often conceptualised as three parallel domains that include all the constituent nuclei...
- Activity patterns in a model for the subthalamopallidal network of the basal gangliaD Terman
Department of Mathematics, The Ohio State University, Columbus, Ohio 43210, USA
J Neurosci 22:2963-76. 2002..of the subthalamic nucleus and the external segment of the globus pallidus in the indirect pathway of the basal ganglia. Computer simulations and analysis of this model illuminate the roles of the coupling architecture of the ..
- Update on models of basal ganglia function and dysfunctionMahlon Delong
Department Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Parkinsonism Relat Disord 15:S237-40. 2009Circuit models of basal ganglia function and dysfunction have undergone significant changes over time...
- Basal ganglia contributions to motor control: a vigorous tutorRobert S Turner
Department of Neurobiology, Systems Neuroscience Institute and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15261, USA
Curr Opin Neurobiol 20:704-16. 2010The roles of the basal ganglia (BG) in motor control are much debated. Many influential hypotheses have grown from studies in which output signals of the BG were not blocked, but pathologically disturbed...
- Abnormal oscillatory synchronisation in the motor system leads to impaired movementP Brown
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
Curr Opin Neurobiol 17:656-64. 2007Converging data suggest that abnormal synchronised oscillatory activity in the basal ganglia may contribute to bradykinesia in patients with Parkinson's disease. This synchrony preferentially occurs over 10-30 Hz, the so-called beta band...
- A physiologically plausible model of action selection and oscillatory activity in the basal gangliaMark D Humphries
Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, Sheffield, S10 2TP, United Kingdom
J Neurosci 26:12921-42. 2006The basal ganglia (BG) have long been implicated in both motor function and dysfunction...
- A basal ganglia-forebrain circuit in the songbird biases motor output to avoid vocal errorsAaron S Andalman
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 106:12518-23. 2009In songbirds, as in mammals, basal ganglia-forebrain circuits are necessary for the learning and production of complex motor behaviors; however, the precise role of these circuits remains unknown...
- Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuitsRichard Levy
Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
Cereb Cortex 16:916-28. 2006The clinical signs grouped under the concept of apathy are a common feature of prefrontal and basal ganglia lesions or dysfunctions and can therefore help to improve our understanding of the functional anatomy of the prefrontal-basal ..
- Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activityAhmad R Hariri
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 26:13213-7. 2006..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction...
- Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholicsAnne Beck
Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
Biol Psychiatry 66:734-42. 2009..We explored whether functional brain activation during anticipation of incentive stimuli is associated with impulsiveness in detoxified alcoholics and healthy control subjects...
- Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine releaseBjörn H Schott
Department of Behavioral Neurology, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
J Neurosci 28:14311-9. 2008..Moreover, the combined neurochemical and hemodynamic imaging approach used here opens up new perspectives for the investigation of molecular mechanisms underlying human cognition...
- How the brain translates money into force: a neuroimaging study of subliminal motivationMathias Pessiglione
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
Science 316:904-6. 2007..Our findings thus reveal this region as a key node in brain circuitry that enables expected rewards to energize behavior, without the need for the subjects;awareness...
- A review of differences between basal ganglia and cerebellar control of movements as revealed by functional imaging studiesM Jueptner
Department of Psychiatry, University Clinics, Essen, Germany
Brain 121:1437-49. 1998The role of the basal ganglia and cerebellum in the control of movements is unclear. We summarize results from three groups of PET studies of regional CBF...
- The role of the basal ganglia in learning and memory: neuropsychological studiesJessica A Grahn
MRC Cognition and Brain Sciences Unit, Cambridge, UK
Behav Brain Res 199:53-60. 2009In recent years, a common approach to understanding how the basal ganglia contribute to learning and memory in humans has been to study the deficits that occur in patients with basal ganglia pathology, such as Parkinson's disease and ..
- Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorderAnnette Estes
University of Washington Autism Center, University of Washington, Seattle, WA 98195, USA
Autism Res 4:212-20. 2011We investigated repetitive and stereotyped behavior (RSB) and its relationship to morphometric measures of the basal ganglia and thalami in 3- to 4-year-old children with autism spectrum disorder (ASD; n = 77) and developmental delay ..
- Event-related potential activity in the basal ganglia differentiates rewards from nonrewards: temporospatial principal components analysis and source localization of the feedback negativityDan Foti
Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
Hum Brain Mapp 32:2207-16. 2011..increased striatal activation in response to favorable outcomes that is reduced or absent for unfavorable outcomes, thereby providing unique information about the timing and nature of basal ganglia activity related to reward processing.
- Neural circuits and topographic organization of the basal ganglia and related regionsK Nakano
Department of Anatomy, Mie University Faculty of Medicine, Tsu, 514 8507, Mie, Japan
Brain Dev 22:S5-16. 2000The present review was attempted to analyze the multiple channels of basal ganglia-thalamocortical connections, and the connections of their related nuclei...
- Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learningAustin T Hilliard
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, USA
Neuron 73:537-52. 2012..vocal communication--a complex phenotype probably supported by ensembles of interacting genes in cortico-basal ganglia pathways of both species. To date, only FoxP2 has been identified as critical to both speech and birdsong...
- Information processing, dimensionality reduction and reinforcement learning in the basal gangliaIzhar Bar-Gad
Center for Neural Computation, The Hebrew University, Jerusalem, Israel
Prog Neurobiol 71:439-73. 2003Modeling of the basal ganglia has played a major role in our understanding of this elusive group of nuclei...
- The basal ganglia and cerebellum interact in the expression of dystonic movementVladimir K Neychev
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Brain 131:2499-509. 2008..Traditional views place responsibility for dystonia with dysfunction of basal ganglia circuits, yet recent evidence has pointed towards cerebellar circuits as well...
- Activity of striatal neurons reflects dynamic encoding and recoding of procedural memoriesTerra D Barnes
Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46 6133, Cambridge, Massachusetts 02139, USA
Nature 437:1158-61. 2005..such learning dynamics, we made long-term recordings from multiple neurons in the sensorimotor striatum, a basal ganglia structure implicated in habit formation, in rats successively trained on a reward-based procedural task, given ..
- Adenosine A2A receptors and basal ganglia physiologyS N Schiffmann
Laboratory of Neurophysiology, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, CP601, 1070 Brussels, Belgium
Prog Neurobiol 83:277-92. 2007Adenosine A2A receptors are highly enriched in the basal ganglia system...
- Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal gangliaJessica A Shuen
Center for Translational Neuroscience, Division of Neurology, Neurotransgenic Core Facility, and Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 28:2681-5. 2008
- Complementary roles of basal ganglia and cerebellum in learning and motor controlK Doya
Information Sciences Division, ATR International and CREST, Japan Science and Technology Corporation, 2 2 2 Hikaridai, Seika, Soraku, 619 0288, Kyoto, Japan
Curr Opin Neurobiol 10:732-9. 2000The classical notion that the basal ganglia and the cerebellum are dedicated to motor control has been challenged by the accumulation of evidence revealing their involvement in non-motor, cognitive functions...
- What do the basal ganglia do? A modeling perspectiveV S Chakravarthy
Department of Biotechnology, Indian Institute of Technology, Madras, Chennai 600036, India
Biol Cybern 103:237-53. 2010b>Basal ganglia (BG) constitute a network of seven deep brain nuclei involved in a variety of crucial brain functions including: action selection, action gating, reward based learning, motor preparation, timing, etc...
- Habenula: crossroad between the basal ganglia and the limbic systemOkihide Hikosaka
Laboratory of Sensorimotor Research, National Eye Institute National Institutes of Health, Bethesda, Maryland 20892 4435, USA
J Neurosci 28:11825-9. 2008..Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis...
- Cortical and basal ganglia contributions to habit learning and automaticityF Gregory Ashby
Department of Psychology, University of California, Santa Barbara, CA 93106, USA
Trends Cogn Sci 14:208-15. 2010..At the same time, other recent reports indicate that automatic behaviors are striatum- and dopamine-independent, and might be mediated entirely within cortex. Resolving this apparent conflict should be a major goal of future research...
- The integrative function of the basal ganglia in instrumental conditioningBernard W Balleine
Department of Psychology and the Brain Research Institute, University of California, Los Angeles, CA, United States
Behav Brain Res 199:43-52. 2009..As the entry point for the basal ganglia, cortical circuits involving the dorsal striatum are clearly in a position to control a variety of motor ..
- Disconnecting force from money: effects of basal ganglia damage on incentive motivationLiane Schmidt
Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, F 75013 Paris, France
Brain 131:1303-10. 2008Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation...
- Vocal experimentation in the juvenile songbird requires a basal ganglia circuitBence P Olveczky
McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
PLoS Biol 3:e153. 2005..Our results establish that, in the juvenile songbird, the exploratory motor behavior required to learn a complex motor sequence is dependent on a dedicated neural circuit homologous to cortico-basal ganglia circuits in mammals.
- Separate neural systems value immediate and delayed monetary rewardsSamuel M McClure
Department of Psychology and Center for the Study of Brain, Mind, and Behavior, Princeton University, Princeton, NJ 08544, USA
Science 306:503-7. 2004..Furthermore, the relative engagement of the two systems is directly associated with subjects' choices, with greater relative fronto-parietal activity when subjects choose longer term options...
- Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addictionDavid Belin
Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB Cambridge, UK
Behav Brain Res 199:89-102. 2009..parallel cortico-striato-pallido-thalamo-cortical loops involved in motor or emotional functions, the basal ganglia, and especially the striatum, are key mediators of the modulation of behavioural responses, under the control ..
- The basal ganglia in Parkinson's disease: current concepts and unexplained observationsJose A Obeso
Departments of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Centre, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Ann Neurol 64:S30-46. 2008..disease is reviewed in light of recent advances in the understanding of the functional organization of the basal ganglia (BG)...
- Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathwayAtsushi Nambu
Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
Neurosci Res 43:111-7. 2002How the motor-related cortical areas modulate the activity of the output nuclei of the basal ganglia is an important issue for understanding the mechanisms of motor control by the basal ganglia...
- Processing of temporal information and the basal ganglia: new evidence from fMRIIgor Nenadic
Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07740 Jena, Germany
Exp Brain Res 148:238-46. 2003..Psychopharmacological and patient studies suggest a crucial role of the basal ganglia in time estimation...
- Multiple representations and algorithms for reinforcement learning in the cortico-basal ganglia circuitMakoto Ito
Neural Computation Unit, Okinawa Institute of Science and Technology, Okinawa 904 0412, Japan
Curr Opin Neurobiol 21:368-73. 2011Accumulating evidence shows that the neural network of the cerebral cortex and the basal ganglia is critically involved in reinforcement learning...
- The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrainM R Bennett
Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
Prog Neurobiol 93:468-87. 2011..Modulation of this prefrontal-limbic network (PLN) is principally through the hypothalamus, basal ganglia and midbrain...
- Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonismMichael J Frank
Department of Psychology and Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA
Science 318:1309-12. 2007..These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.
- Blood oxygenation level-dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's diseaseJaney Prodoehl
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Mov Disord 25:2035-43. 2010..modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures of basal ganglia (BG) function that are sensitive to disease severity...
- Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?Juan Mena-Segovia
MRC Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Trends Neurosci 27:585-8. 2004The basal ganglia are more highly interconnected with the pedunculopontine tegmental nucleus (PPN) than with any other brain region. Regulation and relay of basal ganglia activity are two key functions of the PPN...
- Basal ganglia macrocircuitsJ M Tepper
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Prog Brain Res 160:3-7. 2007..authors covering the anatomy, physiology, biochemistry/pharmacology and behavioral aspects of GABA in the basal ganglia. In this chapter the various nuclei of the basal ganglia are defined and their cellular structure, connections ..
- Conditional routing of information to the cortex: a model of the basal ganglia's role in cognitive coordinationAndrea Stocco
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Psychol Rev 117:541-74. 2010The basal ganglia play a central role in cognition and are involved in such general functions as action selection and reinforcement learning...
- Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injuryGiselle M Petzinger
Department of Neurology, The George and MaryLou Boone Center for Parkinson s Disease Research, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 27:5291-300. 2007....
- Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseasesT Alexi
Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
Prog Neurobiol 60:409-70. 2000..Most of these approaches hold promise as potential therapies in the treatment of these disorders...
- Basal ganglia volume is associated with aerobic fitness in preadolescent childrenLaura Chaddock
Department of Psychology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Dev Neurosci 32:249-56. 2010The present investigation is the first to explore the association between childhood aerobic fitness and basal ganglia structure and function...
- Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activityDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
J Neurosci 26:10789-95. 2006..addition to its involvement in motor control and in encoding reward value, increasing evidence also implicates basal ganglia dopaminergic mechanisms in responses to stress and aversive stimuli...
- Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortexRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neurosci Biobehav Rev 26:321-52. 2002....
- The connections of the primate subthalamic nucleus: indirect pathways and the open-interconnected scheme of basal ganglia-thalamocortical circuitryD Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
Brain Res Brain Res Rev 23:62-78. 1997The current view of basal ganglia organization holds that functionally corresponding subregions of the frontal cortex, basal ganglia and thalamus form several parallel segregated basal ganglia-thalamocortical circuits...
- Interactions between frontal cortex and basal ganglia in working memory: a computational modelM J Frank
University of Colorado, Boulder, Colorado, USA
Cogn Affect Behav Neurosci 1:137-60. 2001The frontal cortex and the basal ganglia interact via a relatively well understood and elaborate system of interconnections...
- Basal ganglia and supplementary motor area subtend duration perception: an fMRI studyA M Ferrandez
Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, LENA, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
Neuroimage 19:1532-44. 2003..the frontal and mesiofrontal cortex (supplementary motor area, SMA), parietal cortex, and subcortical areas (basal ganglia, thalamus, and cerebellum)...
- Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal gangliaBeth E Fisher
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90033, USA
J Neurosci Res 77:378-90. 2004Physical activity has been shown to be neuroprotective in lesions affecting the basal ganglia. Using a treadmill exercise paradigm, we investigated the effect of exercise on neurorestoration...
- Seven problems on the basal gangliaAtsushi Nambu
Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
Curr Opin Neurobiol 18:595-604. 2008Our knowledge on the functions of the basal ganglia has increased enormously during the last two decades. However, we still do not completely understand the primary function of the basal ganglia...
- Interruption of a basal ganglia-forebrain circuit prevents plasticity of learned vocalizationsM S Brainard
Keck Center for Integrative Neuroscience, Department of Physiology, University of California San Francisco, 94143 0444, USA
Nature 404:762-6. 2000..that normally follow deafening can be prevented by a second insult to the nervous system--the lesion of a basal ganglia-forebrain circuit...
- Interaction of stimulus-driven reorienting and expectation in ventral and dorsal frontoparietal and basal ganglia-cortical networksGordon L Shulman
Department of Neurology, Washington University, 4525 Scott Avenue, St Louis, MO 63110, USA
J Neurosci 29:4392-407. 2009..Nevertheless, IFG was activated only by unexpected shifts of attention, dissociating its function from TPJ. Basal ganglia and frontal/insula regions also were activated only when reorienting was unexpected but showed strong rs-fcMRI ..
- Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brainsYoland Smith
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia, USA
Mov Disord 23:S534-47. 2008..Dopamine has long been recognized to be a key neuromodulator of basal ganglia function, essential for normal motor activity...
- Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordingsWilliam D Hutchison
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
J Neurosci 24:9240-3. 2004
- Neurocomputational models of basal ganglia function in learning, memory and choiceMichael X Cohen
Department of Psychology, Program in Neuroscience, University of Arizona, 1503 E University Blvd, Tucson, AZ 85721, United States
Behav Brain Res 199:141-56. 2009The basal ganglia (BG) are critical for the coordination of several motor, cognitive, and emotional functions and become dysfunctional in several pathological states ranging from Parkinson's disease to Schizophrenia...
- Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidusM Desmurget
Department of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
J Neurophysiol 99:1057-76. 2008To test current hypotheses on the contribution of the basal ganglia (BG) to motor control, we examined the effects of muscimol-induced inactivations in the skeletomotor region of the internal globus pallidus (sGPi) on visually directed ..
- Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamineJ R Walters
Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3702, USA
Neuroscience 144:762-76. 2007..of the present study was to determine the phase relationships of the slow oscillatory activity that emerges in basal ganglia nuclei in anesthetized rats after dopamine cell lesion in order to gain insight into the passage of this ..
- Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal gangliaY H Chung
Department of Anatomy, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
Brain Res 875:164-70. 2000..here is the first in which the expression of six Kv1 channel subunits have been directly compared in the rat basal ganglia. In the present study, we have found that staining patterns of the six Kv1 channel subunits overlap in some ..
- An ultra-short dopamine pathway regulates basal ganglia outputFu Wen Zhou
Department of Pharmacology, University of Tennessee College of Medicine, Memphis, TN 38163, USA
J Neurosci 29:10424-35. 2009Substantia nigra pars reticulata (SNr) is a key basal ganglia output nucleus critical for movement control. Its GABA-containing projection neurons intermingle with nigral dopamine (DA) neuron dendrites...
- Basal Ganglia and Higher Cortical FunctionPeter L Strick; Fiscal Year: 2010There is growing evidence that the basal ganglia (BG) participate in multiple segregated "loops" with a wide variety of cortical areas including regions of motor, prefrontal, posterior parietal and inferotemporal cortex...
- Inhibitory Interneurons in Tourette SyndromeFlora Vaccarino; Fiscal Year: 2009..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- Synaptic processing in the basal gangliaDavid J Perkel; Fiscal Year: 2010..The pathway needed for learning song involves the basal ganglia, a set of brain regions known in mammals to be important for motor control, motor learning and a variety of ..
- Thalamostriatal System in ParkinsonismTHOMAS N WICHMANN; Fiscal Year: 2010The centromedian and parafascicular nuclei (CM/PF) of the thalamus receive inputs from the basal ganglia, and send a massive and topographically organized projection back to the striatum...
- CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIASuzanne Haber; Fiscal Year: 2009..obsessive-compulsive disorder (OCD), schizophrenia, and drug addiction are linked to pathology in the cortico-basal ganglia (BG), reward circuit...
- Basal Ganglia and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2009There is growing evidence that the basal ganglia (BG) participate in multiple segregated "loops" with a wide variety of cortical areas including regions of motor, prefrontal, posterior parietal and inferotemporal cortex...
- Cortical connections with the limbic territory of the basal gangliaMichelle Morrow; Fiscal Year: 2007There is growing evidence that the basal ganglia (BG) participate in multiple segregated "loops" with a wide variety of cortical areas including regions of motor, prefrontal, posterior parietal and inferotemporal cortex...
- Molecular Mechanisms Controlling Formation of Basal Ganglia CircuitryKENNETH J CAMPBELL; Fiscal Year: 2010The basal ganglia comprise a collection of nuclei that are primarily involved in controlling purposeful movements and appropriate behavior...
- Cortical and basal ganglia local field potentials in human movement disordersPhilip A Starr; Fiscal Year: 2010..goal of this project is to advance the understanding of movement disorders pathophysiology through studies of basal ganglia and cortical local field potentials (LFPs) in humans...
- Cortical contributions to basal ganglia disordersPETER STRICK; Fiscal Year: 2006There is growing evidence that the basal ganglia participate in multiple 'loops' with a wide variety of cortical areas including regions of motor, premotor, prefrontal, orbitofrontal, cingulated, posterior parietal and inferotemporal ..
- Nigrostriatal Dopamine FunctionJames M Tepper; Fiscal Year: 2010The basal ganglia is an essential component of the central circuitry controlling voluntary movement as well as sensorimotor integration, motor and non-motor learning, and a number of higher cognitive functions...
- Nigrostriatal Dopamine FunctionJames M Tepper; Fiscal Year: 2010The basal ganglia is an essential component of the central circuitry controlling voluntary movement as well as sensorimotor integration, motor and non-motor learning, and a number of higher cognitive functions...
- GABA RECEPTORS IN THE THALAMUSYoland Smith; Fiscal Year: 2005The basal ganglia and thalamus are interconnected through a series of loops that process and convey basal ganglia outflow to either frontal cortical regions via the ventral motor nuclei or back to the striatum via the caudal intralaminar ..
- Inhibitory Interneurons in Tourette SyndromeFlora Vaccarino; Fiscal Year: 2007..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIAPHILIP STARR; Fiscal Year: 2005..been made to understand movement disorders in terms of alterations in a loop circuit involving the cortex, basal ganglia and thalamus...
- DOPAMINERGIC TOXICITY OF ATRAZINE--INFLUENCE OF AGENIKOLAY FILIPOV; Fiscal Year: 2002..during adolescence will potentiate the age-related DA loss, as well as potentiate the toxicity of a typical basal ganglia neurotoxicant such as 1-methyl-4-phenyl-1, 2, 3, 4-tetrahydropyridine (MPTP), and (iii) that a sub-chronic or ..
- Synaptic processing in the basal gangliaDavid Perkel; Fiscal Year: 2009..The pathway needed for learning song involves the basal ganglia, a set of brain regions known in mammals to be important for motor control, motor learning and a variety of ..
- Organization of the Cortical Projection to the Basal GangliaANTON J REINER; Fiscal Year: 2010..we also do now know if our findings for rats are true for primates, and thus clinically relevant to the human basal ganglia. In Aim 1 of the current proposal, we will use in vivo intracellular methods in rats to record from individual ..
- Organization of the Cortical Projection to the Basal GangliaAnton Reiner; Fiscal Year: 2009..we also do now know if our findings for rats are true for primates, and thus clinically relevant to the human basal ganglia. In Aim 1 of the current proposal, we will use in vivo intracellular methods in rats to record from individual ..
- NEURAL CONTROL OF VOLUNTARY MOVEMENTSJerome Sanes; Fiscal Year: 1993This project investigates the role of the basal ganglia in integrating somatic sensory information and motor commands for executing purposeful movements...
- NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTSJerome Sanes; Fiscal Year: 2001This project investigates the role of the basal ganglia in integrating somatic sensory information and motor commands for executing purposeful movements...
- Influence of the Basal Ganglia on Cerebellar ActionAlan Gibson; Fiscal Year: 2007Diseases affecting the basal ganglia produce a variety of movement deficits, and these deficits are often totally disabling. Parkinson's disease, which affects about 1...
- Generation of a mouse model of L-DOPA-responsive dystonia (DRD)ELLEN HESS; Fiscal Year: 2007..Despite a strong clinico-pathological correlation between the basal ganglia and dystonia, there is little understanding of the underlying neuronal dysfunction...
- Pontine motor circuitsJun Lu; Fiscal Year: 2010..Although traditional accounts emphasize the role of reduced dopamine (DA) transmission in the basal ganglia (secondary to loss of midbrain A9 dopamine neurons) in the motoric defects of these disorders, more recent ..
- High Force Resistance Training and Dopamine Replacement Effects on Hypokinesia inLELAND DIBBLE; Fiscal Year: 2007Idiopathic Parkinson disease (IPD) is the model movement disorder to explore the motor function of the basal ganglia. (Morris ME, 2005) Alterations in the output of the basal ganglia lead to reductions in muscle force output and ..
- MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODELCLARA SANUDO PENA; Fiscal Year: 2002The hallmark of Parkinson s disease is a dopamine deficiency in the basal ganglia due to degeneration of dopaminergic neurons in the substantia nigra pars compacta...
- Influence of the Basal Ganglia on Cerebellar ActionAlan Gibson; Fiscal Year: 2004..to be a surprisingly effective approach for the control of movement disorders associated with diseases of the basal ganglia, such as Parkinson's disease...
- Basal Ganglia, Cerebellum, and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2007The classical view is that the outputs from the basal ganglia and cerebellum project to a region of the ventrolateral thalamus that ultimately influences a single cortical area, the primary motor cortex...
- Basal Ganglia, Cerebellum, and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2003The classical view is that the outputs from the basal ganglia and cerebellum project to a region of the ventrolateral thalamus that ultimately influences a single cortical area, the primary motor cortex...