Genomes and Genes
Summary: Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.
Publications322 found, 100 shown here
- Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitryAlexxai V Kravitz
Gladstone Institute of Neurological Disease, 1650 Owens St, San Francisco, California 94158, USA
Nature 466:622-6. 2010Neural circuits of the basal ganglia are critical for motor planning and action selection. Two parallel basal ganglia pathways have been described, and have been proposed to exert opposing influences on motor function...
- Neural representation of time in cortico-basal ganglia circuitsDezhe Z Jin
Department of Physics, Pennsylvania State University, 104 Davey Laboratory, PMB 206, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 106:19156-61. 2009..We searched for time representations in cortico-basal ganglia circuits by recording from thousands of neurons in the prefrontal cortex and striatum of macaque monkeys ..
- Striatal plasticity and basal ganglia circuit functionAnatol C Kreitzer
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Neuron 60:543-54. 2008The dorsal striatum, which consists of the caudate and putamen, is the gateway to the basal ganglia. It receives convergent excitatory afferents from cortex and thalamus and forms the origin of the direct and indirect pathways, which are ..
- The role of the basal ganglia in habit formationHenry H Yin
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, TS 13, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 7:464-76. 2006..How are goal-directed actions transformed into habitual responses? Recent work combining modern behavioural assays and neurobiological analysis of the basal ganglia has begun to yield insights into the neural basis of habit formation.
- The primate basal ganglia: parallel and integrative networksSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Chem Neuroanat 26:317-30. 2003The basal ganglia and frontal cortex operate together to execute goal directed behaviors...
- Synaptic organisation of the basal gangliaJ P Bolam
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, UK
J Anat 196:527-42. 2000The basal ganglia are a group of subcortical nuclei involved in a variety of processes including motor, cognitive and mnemonic functions...
- Circuits and circuit disorders of the basal gangliaMahlon R Delong
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Arch Neurol 64:20-4. 2007Views of the anatomy and function of the basal ganglia and their role in motor and nonmotor disorders have undergone major revisions during the past decades...
- Competition between feedback loops underlies normal and pathological dynamics in the basal gangliaArthur Leblois
, Centre National de la Recherche Scientifique, , , 75270 Paris, France
J Neurosci 26:3567-83. 2006Experiments performed in normal animals suggest that the basal ganglia (BG) are crucial in motor program selection. BG are also involved in movement disorders...
- The basal ganglia communicate with the cerebellumAndreea C Bostan
Department of Neurobiology, University of Pittsburgh School of Medicine, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 107:8452-6. 2010The basal ganglia and cerebellum are major subcortical structures that influence not only movement, but putatively also cognition and affect. Both structures receive input from and send output to the cerebral cortex...
- Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brainJuliana Yacubian
Department of Systems Neuroscience, NeuroImage Nord, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany
J Neurosci 26:9530-7. 2006..Prevalence of either part might render expectations more positive or negative, which could contribute to the pathophysiology of mood disorders like major depression...
- Temporal processing in the basal gangliaD L Harrington
Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA
Neuropsychology 12:3-12. 1998This study investigated the role of the basal ganglia in timing operations...
- Role of the basal ganglia in the control of purposive saccadic eye movementsO Hikosaka
Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
Physiol Rev 80:953-78. 2000In addition to their well-known role in skeletal movements, the basal ganglia control saccadic eye movements (saccades) by means of their connection to the superior colliculus (SC)...
- Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated ParkinsonismMichael J Frank
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, CO 80309, USA
J Cogn Neurosci 17:51-72. 2005Dopamine (DA) depletion in the basal ganglia (BG) of Parkinson's patients gives rise to both frontal-like and implicit learning impairments...
- The neural representation of timeRichard B Ivry
3210 Tolman Hall, Department of Psychology, University of California, Berkeley, California 94720 1650 USA
Curr Opin Neurobiol 14:225-32. 2004..Emphasis has also been placed on the basal ganglia as a specialized timing system, particularly for longer intervals...
- Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's diseasePeter Brown
Sobell Department of Neurophysiology and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 18:357-63. 2003Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges between neurones...
- Evidence for segregated and integrative connectivity patterns in the human Basal GangliaBogdan Draganski
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
J Neurosci 28:7143-52. 2008Detailed knowledge of the anatomy and connectivity pattern of cortico-basal ganglia circuits is essential to an understanding of abnormal cortical function and pathophysiology associated with a wide range of neurological and ..
- Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuitsMathias Pessiglione
, , , 75651 Paris, France
J Neurosci 25:1523-31. 2005..firing rate and bursty firing pattern, and assumes that dopamine depletion results in a hyperactivity of basal ganglia (BG) output structures...
- The basal ganglia: learning new tricks and loving itAnn M Graybiel
Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46 6133, Cambridge, MA, 02139 USA
Curr Opin Neurobiol 15:638-44. 2005The field of basal ganglia research is exploding on every level - from discoveries at the molecular level to those based on human brain imaging...
- Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behaviorLuc Mallet
Institut National de la Santé et de la Recherche Médicale AVENIR Group, Behavior, Emotion, and Basal Ganglia, 75013 Paris, France
Proc Natl Acad Sci U S A 104:10661-6. 2007....
- A computational model of action selection in the basal ganglia. I. A new functional anatomyK Gurney
Department of Psychology, University of Sheffield, Sheffield S10 2TP, UK
Biol Cybern 84:401-10. 2001We present a biologically plausible model of processing intrinsic to the basal ganglia based on the computational premise that action selection is a primary role of these central brain structures...
- Basal ganglia orient eyes to rewardOkihide Hikosaka
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Neurophysiol 95:567-84. 2006..Recent studies suggest an important role of the basal ganglia. Sensorimotor/cognitive activities of neurons in the basal ganglia are strongly modulated by expected reward...
- Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's diseaseCatherine R G Jones
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
Brain Cogn 68:30-41. 2008..in the timing literature is that temporal processing in the milliseconds and seconds range engages the basal ganglia and is modulated by dopamine...
- Prefrontal cortex and basal ganglia control access to working memoryFiona McNab
Developmental Cognitive Neuroscience, Stockholm Brain Institute, Karolinska Institutet, MR Centrum, Stockholm, Sweden
Nat Neurosci 11:103-7. 2008..Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, ..
- How the brain translates money into force: a neuroimaging study of subliminal motivationMathias Pessiglione
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
Science 316:904-6. 2007..Our findings thus reveal this region as a key node in brain circuitry that enables expected rewards to energize behavior, without the need for the subjects;awareness...
- Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activityAhmad R Hariri
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 26:13213-7. 2006..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction...
- Information processing, dimensionality reduction and reinforcement learning in the basal gangliaIzhar Bar-Gad
Center for Neural Computation, The Hebrew University, Jerusalem, Israel
Prog Neurobiol 71:439-73. 2003Modeling of the basal ganglia has played a major role in our understanding of this elusive group of nuclei...
- Adenosine A2A receptors and basal ganglia physiologyS N Schiffmann
Laboratory of Neurophysiology, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, CP601, 1070 Brussels, Belgium
Prog Neurobiol 83:277-92. 2007Adenosine A2A receptors are highly enriched in the basal ganglia system...
- Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal gangliaJessica A Shuen
Center for Translational Neuroscience, Division of Neurology, Neurotransgenic Core Facility, and Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 28:2681-5. 2008
- The basal ganglia and cerebellum interact in the expression of dystonic movementVladimir K Neychev
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Brain 131:2499-509. 2008..Traditional views place responsibility for dystonia with dysfunction of basal ganglia circuits, yet recent evidence has pointed towards cerebellar circuits as well...
- Complementary roles of basal ganglia and cerebellum in learning and motor controlK Doya
Information Sciences Division, ATR International and CREST, Japan Science and Technology Corporation, 2 2 2 Hikaridai, Seika, Soraku, 619 0288, Kyoto, Japan
Curr Opin Neurobiol 10:732-9. 2000The classical notion that the basal ganglia and the cerebellum are dedicated to motor control has been challenged by the accumulation of evidence revealing their involvement in non-motor, cognitive functions...
- Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?Juan Mena-Segovia
MRC Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Trends Neurosci 27:585-8. 2004The basal ganglia are more highly interconnected with the pedunculopontine tegmental nucleus (PPN) than with any other brain region. Regulation and relay of basal ganglia activity are two key functions of the PPN...
- Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuitsRichard Levy
Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
Cereb Cortex 16:916-28. 2006The clinical signs grouped under the concept of apathy are a common feature of prefrontal and basal ganglia lesions or dysfunctions and can therefore help to improve our understanding of the functional anatomy of the prefrontal-basal ..
- Activity of striatal neurons reflects dynamic encoding and recoding of procedural memoriesTerra D Barnes
Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46-6133, Cambridge, Massachusetts 02139, USA
Nature 437:1158-61. 2005..such learning dynamics, we made long-term recordings from multiple neurons in the sensorimotor striatum, a basal ganglia structure implicated in habit formation, in rats successively trained on a reward-based procedural task, given ..
- Movement-related changes in synchronization in the human basal gangliaMichael Cassidy
Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, UK
Brain 125:1235-46. 2002There is a wealth of data suggesting that behavioural events are reflected in the basal ganglia through phasic changes in the discharge of individual neurones...
- A humanized version of Foxp2 affects cortico-basal ganglia circuits in miceWolfgang Enard
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Cell 137:961-71. 2009..behavior and decreased dopamine concentrations in the brain suggesting that the humanized Foxp2 allele affects basal ganglia. In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional ..
- A physiologically plausible model of action selection and oscillatory activity in the basal gangliaMark D Humphries
Adaptive Behaviour Research Group, Department of Psychology, University of Sheffield, Sheffield, S10 2TP, United Kingdom
J Neurosci 26:12921-42. 2006The basal ganglia (BG) have long been implicated in both motor function and dysfunction...
- Actor-critic models of the basal ganglia: new anatomical and computational perspectivesDaphna Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
Neural Netw 15:535-47. 2002A large number of computational models of information processing in the basal ganglia have been developed in recent years...
- Separate neural systems value immediate and delayed monetary rewardsSamuel M McClure
Department of Psychology and Center for the Study of Brain, Mind, and Behavior, Princeton University, Princeton, NJ 08544, USA
Science 306:503-7. 2004..Furthermore, the relative engagement of the two systems is directly associated with subjects' choices, with greater relative fronto-parietal activity when subjects choose longer term options...
- Processing of temporal information and the basal ganglia: new evidence from fMRIIgor Nenadic
Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07740 Jena, Germany
Exp Brain Res 148:238-46. 2003..Psychopharmacological and patient studies suggest a crucial role of the basal ganglia in time estimation...
- Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injuryGiselle M Petzinger
Department of Neurology, The George and MaryLou Boone Center for Parkinson s Disease Research, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 27:5291-300. 2007....
- Basal ganglia contributions to motor control: a vigorous tutorRobert S Turner
Department of Neurobiology, Systems Neuroscience Institute and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15261, USA
Curr Opin Neurobiol 20:704-16. 2010The roles of the basal ganglia (BG) in motor control are much debated. Many influential hypotheses have grown from studies in which output signals of the BG were not blocked, but pathologically disturbed...
- Conditional routing of information to the cortex: a model of the basal ganglia's role in cognitive coordinationAndrea Stocco
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Psychol Rev 117:541-74. 2010The basal ganglia play a central role in cognition and are involved in such general functions as action selection and reinforcement learning...
- Cortical and basal ganglia contributions to habit learning and automaticityF Gregory Ashby
Department of Psychology, University of California, Santa Barbara, CA 93106, USA
Trends Cogn Sci 14:208-15. 2010..At the same time, other recent reports indicate that automatic behaviors are striatum- and dopamine-independent, and might be mediated entirely within cortex. Resolving this apparent conflict should be a major goal of future research...
- The cortico-basal ganglia integrative network: the role of the thalamusSuzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA suzanne
Brain Res Bull 78:69-74. 2009The thalamus is a critical component of the frontal cortical-basal ganglia-thalamic circuits that mediate motivation and emotional drive, planning and cognition for the development and expression of goal-directed behaviors...
- Basal ganglia macrocircuitsJ M Tepper
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Prog Brain Res 160:3-7. 2007..authors covering the anatomy, physiology, biochemistry/pharmacology and behavioral aspects of GABA in the basal ganglia. In this chapter the various nuclei of the basal ganglia are defined and their cellular structure, connections ..
- Contributions of the basal ganglia and functionally related brain structures to motor learningJulien Doyon
Functional Neuroimaging Unit, University of Montreal Geriatric Institute, Montreal, Quebec, Canada
Behav Brain Res 199:61-75. 2009..These results are then put into a plausible neurobiological model of motor skill learning, which proposes an integrated view of the brain plasticity mediating this form of memory at different stages of the acquisition process...
- Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseasesT Alexi
Research Centre for Developmental Medicine and Biology, School of Medicine, University of Auckland, New Zealand
Prog Neurobiol 60:409-70. 2000..Most of these approaches hold promise as potential therapies in the treatment of these disorders...
- Neural circuits and topographic organization of the basal ganglia and related regionsK Nakano
Department of Anatomy, Mie University Faculty of Medicine, Tsu, 514 8507, Mie, Japan
Brain Dev 22:S5-16. 2000The present review was attempted to analyze the multiple channels of basal ganglia-thalamocortical connections, and the connections of their related nuclei...
- Goal-directed and habitual control in the basal ganglia: implications for Parkinson's diseasePeter Redgrave
Neuroscience Research Unit, Department of Psychology, University of Sheffield, UK
Nat Rev Neurosci 11:760-72. 2010Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease...
- Basal ganglia volume is associated with aerobic fitness in preadolescent childrenLaura Chaddock
Department of Psychology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Dev Neurosci 32:249-56. 2010The present investigation is the first to explore the association between childhood aerobic fitness and basal ganglia structure and function...
- Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activityDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109-0720, USA
J Neurosci 26:10789-95. 2006..addition to its involvement in motor control and in encoding reward value, increasing evidence also implicates basal ganglia dopaminergic mechanisms in responses to stress and aversive stimuli...
- The connections of the primate subthalamic nucleus: indirect pathways and the open-interconnected scheme of basal ganglia-thalamocortical circuitryD Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
Brain Res Brain Res Rev 23:62-78. 1997The current view of basal ganglia organization holds that functionally corresponding subregions of the frontal cortex, basal ganglia and thalamus form several parallel segregated basal ganglia-thalamocortical circuits...
- Functional connectivity of human striatum: a resting state FMRI studyA Di Martino
Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
Cereb Cortex 18:2735-47. 2008Classically regarded as motor structures, the basal ganglia subserve a wide range of functions, including motor, cognitive, motivational, and emotional processes...
- Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortexRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neurosci Biobehav Rev 26:321-52. 2002....
- Interactions between frontal cortex and basal ganglia in working memory: a computational modelM J Frank
University of Colorado, Boulder, Colorado, USA
Cogn Affect Behav Neurosci 1:137-60. 2001The frontal cortex and the basal ganglia interact via a relatively well understood and elaborate system of interconnections...
- Basal ganglia and supplementary motor area subtend duration perception: an fMRI studyA M Ferrandez
Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, LENA, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
Neuroimage 19:1532-44. 2003..the frontal and mesiofrontal cortex (supplementary motor area, SMA), parietal cortex, and subcortical areas (basal ganglia, thalamus, and cerebellum)...
- Activity patterns in a model for the subthalamopallidal network of the basal gangliaD Terman
Department of Mathematics, The Ohio State University, Columbus, Ohio 43210, USA
J Neurosci 22:2963-76. 2002..of the subthalamic nucleus and the external segment of the globus pallidus in the indirect pathway of the basal ganglia. Computer simulations and analysis of this model illuminate the roles of the coupling architecture of the ..
- Interruption of a basal ganglia-forebrain circuit prevents plasticity of learned vocalizationsM S Brainard
Keck Center for Integrative Neuroscience, Department of Physiology, University of California San Francisco, 94143 0444, USA
Nature 404:762-6. 2000..that normally follow deafening can be prevented by a second insult to the nervous system--the lesion of a basal ganglia-forebrain circuit...
- Interaction of stimulus-driven reorienting and expectation in ventral and dorsal frontoparietal and basal ganglia-cortical networksGordon L Shulman
Department of Neurology, Washington University, 4525 Scott Avenue, St Louis, MO 63110, USA
J Neurosci 29:4392-407. 2009..Nevertheless, IFG was activated only by unexpected shifts of attention, dissociating its function from TPJ. Basal ganglia and frontal/insula regions also were activated only when reorienting was unexpected but showed strong rs-fcMRI ..
- The role of the basal ganglia in learning and memory: neuropsychological studiesJessica A Grahn
MRC Cognition and Brain Sciences Unit, Cambridge, UK
Behav Brain Res 199:53-60. 2009In recent years, a common approach to understanding how the basal ganglia contribute to learning and memory in humans has been to study the deficits that occur in patients with basal ganglia pathology, such as Parkinson's disease and ..
- Cortico-Basal Ganglia reward network: microcircuitrySusan R Sesack
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 35:27-47. 2010..A fuller appreciation of the circuitry interconnecting the nucleus accumbens and ventral tegmental area should serve to advance discovery of new treatment options for these conditions...
- Seven problems on the basal gangliaAtsushi Nambu
Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
Curr Opin Neurobiol 18:595-604. 2008Our knowledge on the functions of the basal ganglia has increased enormously during the last two decades. However, we still do not completely understand the primary function of the basal ganglia...
- Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal gangliaBeth E Fisher
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90033, USA
J Neurosci Res 77:378-90. 2004Physical activity has been shown to be neuroprotective in lesions affecting the basal ganglia. Using a treadmill exercise paradigm, we investigated the effect of exercise on neurorestoration...
- Neurocomputational models of basal ganglia function in learning, memory and choiceMichael X Cohen
Department of Psychology, Program in Neuroscience, University of Arizona, 1503 E University Blvd, Tucson, AZ 85721, United States
Behav Brain Res 199:141-56. 2009The basal ganglia (BG) are critical for the coordination of several motor, cognitive, and emotional functions and become dysfunctional in several pathological states ranging from Parkinson's disease to Schizophrenia...
- Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addictionDavid Belin
Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB Cambridge, UK
Behav Brain Res 199:89-102. 2009..parallel cortico-striato-pallido-thalamo-cortical loops involved in motor or emotional functions, the basal ganglia, and especially the striatum, are key mediators of the modulation of behavioural responses, under the control ..
- Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brainsYoland Smith
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, Georgia, USA
Mov Disord 23:S534-47. 2008..Dopamine has long been recognized to be a key neuromodulator of basal ganglia function, essential for normal motor activity...
- Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordingsWilliam D Hutchison
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
J Neurosci 24:9240-3. 2004
- Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidusM Desmurget
Department of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
J Neurophysiol 99:1057-76. 2008To test current hypotheses on the contribution of the basal ganglia (BG) to motor control, we examined the effects of muscimol-induced inactivations in the skeletomotor region of the internal globus pallidus (sGPi) on visually directed ..
- Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamineJ R Walters
Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3702, USA
Neuroscience 144:762-76. 2007..of the present study was to determine the phase relationships of the slow oscillatory activity that emerges in basal ganglia nuclei in anesthetized rats after dopamine cell lesion in order to gain insight into the passage of this ..
- Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal gangliaY H Chung
Department of Anatomy, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, South Korea
Brain Res 875:164-70. 2000..here is the first in which the expression of six Kv1 channel subunits have been directly compared in the rat basal ganglia. In the present study, we have found that staining patterns of the six Kv1 channel subunits overlap in some ..
- An ultra-short dopamine pathway regulates basal ganglia outputFu Wen Zhou
Department of Pharmacology, University of Tennessee College of Medicine, Memphis, TN 38163, USA
J Neurosci 29:10424-35. 2009Substantia nigra pars reticulata (SNr) is a key basal ganglia output nucleus critical for movement control. Its GABA-containing projection neurons intermingle with nigral dopamine (DA) neuron dendrites...
- Development and evolution of the subpalliumNerea Moreno
Dpt of Cell Biology, Faculty of Biology, University Complutense of Madrid, Av Jose Antonio Novais, 2, 28040 Madrid, Spain
Semin Cell Dev Biol 20:735-43. 2009..e. the basal ganglia and the amygdaloid complex, are highly conserved through evolution...
- Vocal emotion processing in Parkinson's disease: reduced sensitivity to negative emotionsChinar Dara
School of Communication Sciences and Disorders, McGill University, Montreal, QC, Canada
Brain Res 1188:100-11. 2008To document the impact of Parkinson's disease (PD) on communication and to further clarify the role of the basal ganglia in the processing of emotional speech prosody, this investigation compared how PD patients identify basic emotions ..
- Functional organization of the basal ganglia: therapeutic implications for Parkinson's diseaseJose A Obeso
Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
Mov Disord 23:S548-59. 2008The basal ganglia (BG) are a highly organized network, where different parts are activated for specific functions and circumstances...
- The nucleus accumbens as part of a basal ganglia action selection circuitSaleem M Nicola
Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton St, Ste 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 191:521-50. 2007BACKGROUND: The nucleus accumbens is the ventral extent of the striatum, the main input nucleus of the basal ganglia. Recent hypotheses propose that the accumbens and its dopamine projection from the midbrain contribute to appetitive ..
- Differential responses in human striatum and prefrontal cortex to changes in object and rule relevanceRoshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
J Neurosci 24:1129-35. 2004....
- Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine releaseBjörn H Schott
Department of Behavioral Neurology, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
J Neurosci 28:14311-9. 2008..Moreover, the combined neurochemical and hemodynamic imaging approach used here opens up new perspectives for the investigation of molecular mechanisms underlying human cognition...
- Open interconnected model of basal ganglia-thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's diseaseD Joel
Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Mov Disord 16:407-23. 2001..Correspondingly, current models implicate dysfunction of the motor, associative, and limbic basal ganglia-thalamocortical circuits...
- Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia functionHiromi Sano
Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
J Neurosci 23:9078-88. 2003Dopamine (DA) exerts synaptic organization of basal ganglia circuitry through a variety of neuronal populations in the striatum...
- Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disordersVincenzo Di Matteo
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, 66030 Santa Maria, Imbaro, Chieti, Italy
Prog Brain Res 172:423-63. 2008..the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. These observations are supported by anatomical evidence demonstrating large serotonergic innervation of all ..
- Neostriatal cell subtypes and their functional rolesY Kawaguchi
Bio Mimetic Control Research Center, Institute of Physical and Chemical Research RIKEN, Nagoya, Japan
Neurosci Res 27:1-8. 1997..In this article, how these cell subtypes are organized in the local circuitry of the striatum and their physiological roles in the basal ganglia are discussed.
- Functional and pathophysiological models of the basal gangliaT Wichmann
Department of Neurology, Emory University School of Medicine, Suite 6000, Woodruff Memorial Research Building, 1639 Pierce Drive, Atlanta, Georgia 30322, USA
Curr Opin Neurobiol 6:751-8. 1996Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny...
- A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidusD Plenz
Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
Nature 400:677-82. 1999The subthalamic nucleus of the basal ganglia (STN) is important for normal movement as well as in movement disorders. Lesioning or deep-brain stimulation of the STN can alleviate resting tremor in Parkinson's disease...
- Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complicationsMicaela Morelli
University of Cagliari, Department of Toxicology, Via Ospedale 72, 09124 Cagliari, Italy
Prog Neurobiol 83:293-309. 2007Adenosine A2A receptors have a unique cellular and regional distribution in the basal ganglia, being particularly concentrated in areas richly innervated by dopamine such as the caudate-putamen and the globus pallidus...
- Functional anatomy of thalamus and basal gangliaMaria Trinidad Herrero
Experimental Neurology and Neurosurgery Group, Department of Morphological Sciences and Psychobiology, School of Medicine, University of Murcia, Campus Espinardo, 30071 Murcia, Spain
Childs Nerv Syst 18:386-404. 2002..b>BASAL GANGLIA: Basal ganglia form a major centre in the complex extrapyramidal motor system, as opposed to the pyramidal ..
- Lack of ventral striatal response to positive stimuli in depressed versus normal subjectsJane Epstein
Department of Psychiatry, Box 140, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
Am J Psychiatry 163:1784-90. 2006....
- Synaptic plasticity in the basal gangliaJeffery R Wickens
Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
Behav Brain Res 199:119-28. 2009Activity-dependent synaptic plasticity occurs in several parts of the basal ganglia. Increasing evidence supports the hypothesis that activity-dependent plasticity underlies the acquisition, maintenance, and extinction of certain types ..
- Anatomical correlates of early mutism in progressive nonfluent aphasiaM L Gorno-Tempini
UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
Neurology 67:1849-51. 2006..In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in ..
- The neural basis of loss aversion in decision-making under riskSabrina M Tom
Department of Psychology, University of California Los Angeles UCLA, Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Science 315:515-8. 2007..Finally, individual differences in behavioral loss aversion were predicted by a measure of neural loss aversion in several regions, including the ventral striatum and prefrontal cortex...
- Reduced recruitment of motor association areas during bimanual coordination in concert pianistsBernhard Haslinger
Neurologische Klinik, , , Germany
Hum Brain Mapp 22:206-15. 2004..including anterior cingulate cortex, right dorsal premotor cortex, both cerebellar hemispheres, and right basal ganglia. The direct comparison of bimanual parallel to mirror movements between both groups revealed stronger signal ..
- Neuroimaging and neurophysiology of periodic lateralized epileptiform discharges: observations and hypothesesGiridhar P Kalamangalam
Section of Epilepsy, Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA
Epilepsia 48:1396-405. 2007..Our observations led us to consider a conceptual synthesis between PLEDs and periodic complexes (PCs)...
- Increased number of subcortical hyperintensities on MRI in children and adolescents with Tourette's syndrome, obsessive-compulsive disorder, and attention deficit hyperactivity disorderJose A Amat
Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 74, New York, NY 10032, USA
Am J Psychiatry 163:1106-8. 2006..the patient groups, the likelihood of detecting cerebral hyperintensities in the subcortex (primarily the basal ganglia and thalamus) was significantly greater than in the cortex...
- Hypophonia in Parkinson's disease: neural correlates of voice treatment revealed by PETM Liotti
Research Imaging Center, Department of Medicine, University of Texas Health Science Center at San Antonio, TX, USA
Neurology 60:432-40. 2003..To investigate the neural correlates of hypophonia in individuals with idiopathic PD (IPD) before and after voice treatment with the Lee Silverman Voice Treatment method (VT) using (15)O-H(2)O PET...
- Selective activation of ectopic grey matter during motor taskB Draganski
Department of Neurology, University of Regensburg, Universitatsstrasse 84, D 93053 Regensburg, Germany
Neuroreport 15:251-3. 2004..We also observed activation in the cerebellum ipsilaterally and in the basal ganglia contralaterally...
- Basal ganglia oscillations and pathophysiology of movement disordersMichal Rivlin-Etzion
Department of Physiology, The Interdisciplinary Center for Neural Computation, The Hebrew University-Hadassah Medical School, Jerusalem, Israel, 91120
Curr Opin Neurobiol 16:629-37. 2006..Current physiological studies and models of the basal ganglia differ as to which aspects of neuronal activity are crucial to the pathophysiology of Parkinson's disease...
- Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonismAnne Sophie Rolland
INSERM, UMR679, Neurology and Experimental Therapeutics, Paris, France
Brain 130:265-75. 2007We have examined whether degeneration of nigrostriatal dopaminergic neurons causes dysfunction of both the basal ganglia-thalamic and cerebello-thalamic pathways...
- Oscillations in the basal ganglia under normal conditions and in movement disordersPlamen Gatev
Yerkes National Primate Center, Emory University, Atlanta, Georgia 30322, USA
Mov Disord 21:1566-77. 2006..within the last decade has demonstrated that there is a variety of oscillatory phenomena that occur in the basal ganglia and in associated regions of the thalamus and cortex...
- Ferritin levels and their association with regional brain volumes in Tourette's syndromeDaniel A Gorman
Department of Psychiatry, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
Am J Psychiatry 163:1264-72. 2006..The authors measured peripheral iron indices in a large group of Tourette's syndrome and comparison subjects and explored associations of ferritin levels with regional brain volumes...
- A Bayesian approach to determining connectivity of the human brainRajan S Patel
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Hum Brain Mapp 27:267-76. 2006..Our method can be used to develop causal brain networks for use with structural equation modeling and dynamic causal models...
- Investigating emotion with music: an fMRI studyStefan Koelsch
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Hum Brain Mapp 27:239-50. 2006....
- Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depressionLars V Kristiansen
Department of Psychiatry and The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Schizophr Res 78:87-93. 2005....
- Basal Ganglia and Higher Cortical FunctionPeter L Strick; Fiscal Year: 2010There is growing evidence that the basal ganglia (BG) participate in multiple segregated "loops" with a wide variety of cortical areas including regions of motor, prefrontal, posterior parietal and inferotemporal cortex...
- Inhibitory Interneurons in Tourette SyndromeFlora Vaccarino; Fiscal Year: 2009..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- Synaptic processing in the basal gangliaDavid J Perkel; Fiscal Year: 2010..The pathway needed for learning song involves the basal ganglia, a set of brain regions known in mammals to be important for motor control, motor learning and a variety of ..
- Thalamostriatal System in ParkinsonismTHOMAS N WICHMANN; Fiscal Year: 2010The centromedian and parafascicular nuclei (CM/PF) of the thalamus receive inputs from the basal ganglia, and send a massive and topographically organized projection back to the striatum...
- CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIASuzanne Haber; Fiscal Year: 2009..obsessive-compulsive disorder (OCD), schizophrenia, and drug addiction are linked to pathology in the cortico-basal ganglia (BG), reward circuit...
- Basal Ganglia and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2009There is growing evidence that the basal ganglia (BG) participate in multiple segregated "loops" with a wide variety of cortical areas including regions of motor, prefrontal, posterior parietal and inferotemporal cortex...
- Cortical connections with the limbic territory of the basal gangliaMichelle Morrow; Fiscal Year: 2007There is growing evidence that the basal ganglia (BG) participate in multiple segregated "loops" with a wide variety of cortical areas including regions of motor, prefrontal, posterior parietal and inferotemporal cortex...
- Molecular Mechanisms Controlling Formation of Basal Ganglia CircuitryKENNETH J CAMPBELL; Fiscal Year: 2010The basal ganglia comprise a collection of nuclei that are primarily involved in controlling purposeful movements and appropriate behavior...
- Cortical and basal ganglia local field potentials in human movement disordersPhilip A Starr; Fiscal Year: 2010..goal of this project is to advance the understanding of movement disorders pathophysiology through studies of basal ganglia and cortical local field potentials (LFPs) in humans...
- Cortical contributions to basal ganglia disordersPETER STRICK; Fiscal Year: 2006There is growing evidence that the basal ganglia participate in multiple 'loops' with a wide variety of cortical areas including regions of motor, premotor, prefrontal, orbitofrontal, cingulated, posterior parietal and inferotemporal ..
- Organization of the Cortical Projection to the Basal GangliaANTON J REINER; Fiscal Year: 2010..we also do now know if our findings for rats are true for primates, and thus clinically relevant to the human basal ganglia. In Aim 1 of the current proposal, we will use in vivo intracellular methods in rats to record from individual ..
- Organization of the Cortical Projection to the Basal GangliaAnton Reiner; Fiscal Year: 2009..we also do now know if our findings for rats are true for primates, and thus clinically relevant to the human basal ganglia. In Aim 1 of the current proposal, we will use in vivo intracellular methods in rats to record from individual ..
- Nigrostriatal Dopamine FunctionJames M Tepper; Fiscal Year: 2010The basal ganglia is an essential component of the central circuitry controlling voluntary movement as well as sensorimotor integration, motor and non-motor learning, and a number of higher cognitive functions...
- Nigrostriatal Dopamine FunctionJames M Tepper; Fiscal Year: 2010The basal ganglia is an essential component of the central circuitry controlling voluntary movement as well as sensorimotor integration, motor and non-motor learning, and a number of higher cognitive functions...
- GABA RECEPTORS IN THE THALAMUSYoland Smith; Fiscal Year: 2005The basal ganglia and thalamus are interconnected through a series of loops that process and convey basal ganglia outflow to either frontal cortical regions via the ventral motor nuclei or back to the striatum via the caudal intralaminar ..
- Inhibitory Interneurons in Tourette SyndromeFlora Vaccarino; Fiscal Year: 2007..The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
- PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIAPHILIP STARR; Fiscal Year: 2005..been made to understand movement disorders in terms of alterations in a loop circuit involving the cortex, basal ganglia and thalamus...
- DOPAMINERGIC TOXICITY OF ATRAZINE--INFLUENCE OF AGENIKOLAY FILIPOV; Fiscal Year: 2002..during adolescence will potentiate the age-related DA loss, as well as potentiate the toxicity of a typical basal ganglia neurotoxicant such as 1-methyl-4-phenyl-1, 2, 3, 4-tetrahydropyridine (MPTP), and (iii) that a sub-chronic or ..
- Synaptic processing in the basal gangliaDavid Perkel; Fiscal Year: 2009..The pathway needed for learning song involves the basal ganglia, a set of brain regions known in mammals to be important for motor control, motor learning and a variety of ..
- Influence of the Basal Ganglia on Cerebellar ActionAlan Gibson; Fiscal Year: 2007Diseases affecting the basal ganglia produce a variety of movement deficits, and these deficits are often totally disabling. Parkinson's disease, which affects about 1...
- NEURAL CONTROL OF VOLUNTARY MOVEMENTSJerome Sanes; Fiscal Year: 1993This project investigates the role of the basal ganglia in integrating somatic sensory information and motor commands for executing purposeful movements...
- NEURAL CONTROL OF HUMAN VOLUNTARY MOVEMENTSJerome Sanes; Fiscal Year: 2001This project investigates the role of the basal ganglia in integrating somatic sensory information and motor commands for executing purposeful movements...
- Generation of a mouse model of L-DOPA-responsive dystonia (DRD)ELLEN HESS; Fiscal Year: 2007..Despite a strong clinico-pathological correlation between the basal ganglia and dystonia, there is little understanding of the underlying neuronal dysfunction...
- Pontine motor circuitsJun Lu; Fiscal Year: 2010..Although traditional accounts emphasize the role of reduced dopamine (DA) transmission in the basal ganglia (secondary to loss of midbrain A9 dopamine neurons) in the motoric defects of these disorders, more recent ..
- High Force Resistance Training and Dopamine Replacement Effects on Hypokinesia inLELAND DIBBLE; Fiscal Year: 2007Idiopathic Parkinson disease (IPD) is the model movement disorder to explore the motor function of the basal ganglia. (Morris ME, 2005) Alterations in the output of the basal ganglia lead to reductions in muscle force output and ..
- Influence of the Basal Ganglia on Cerebellar ActionAlan Gibson; Fiscal Year: 2004..to be a surprisingly effective approach for the control of movement disorders associated with diseases of the basal ganglia, such as Parkinson's disease...
- MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODELCLARA SANUDO PENA; Fiscal Year: 2002The hallmark of Parkinson s disease is a dopamine deficiency in the basal ganglia due to degeneration of dopaminergic neurons in the substantia nigra pars compacta...
- Basal Ganglia, Cerebellum, and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2007The classical view is that the outputs from the basal ganglia and cerebellum project to a region of the ventrolateral thalamus that ultimately influences a single cortical area, the primary motor cortex...
- Basal Ganglia, Cerebellum, and Higher Cortical FunctionPETER STRICK; Fiscal Year: 2003The classical view is that the outputs from the basal ganglia and cerebellum project to a region of the ventrolateral thalamus that ultimately influences a single cortical area, the primary motor cortex...