telencephalon

Summary

Summary: Paired anteriolateral evaginations of the prosencephalon plus the lamina terminalis. The cerebral hemispheres are derived from it. Many authors consider cerebrum a synonymous term to telencephalon, though a minority include diencephalon as part of the cerebrum (Anthoney, 1994).

Top Publications

  1. pmc Revised nomenclature for avian telencephalon and some related brainstem nuclei
    Anton Reiner
    Department of Anatomy, University of Tennessee Health Science Center, Memphis 38163, USA
    J Comp Neurol 473:377-414. 2004
  2. ncbi Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon
    Teresa Giraldez
    Unidad de Farmacologia, Universidad de La Laguna, La Laguna, Tenerife, Spain
    J Neurochem 102:1304-15. 2007
  3. ncbi Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
  4. ncbi The origin and specification of cortical interneurons
    Carl P Wonders
    Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York 10021, USA
    Nat Rev Neurosci 7:687-96. 2006
  5. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
  6. pmc A high-resolution enhancer atlas of the developing telencephalon
    Axel Visel
    Genomics Division, MS 84 171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cell 152:895-908. 2013
  7. pmc Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis
    Wulf Haubensak
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 101:3196-201. 2004
  8. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
  9. ncbi Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures
    J M Hebert
    Department of Biological Sciences, Stanford University, Stanford, California, 94305 5020, USA
    Dev Biol 222:296-306. 2000
  10. ncbi Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon
    Martin März
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
    Glia 58:870-88. 2010

Research Grants

  1. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
  2. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
  3. TECTOPULVINAR SYSTEM: MOTION DETECTION AND EVOLUTION
    Harvey Karten; Fiscal Year: 2004
  4. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
  5. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
  6. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2012
  7. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Michael W Miller; Fiscal Year: 2010
  8. Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase
    Biplab Dasgupta; Fiscal Year: 2013
  9. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Frank A Middleton; Fiscal Year: 2013
  10. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013

Detail Information

Publications282 found, 100 shown here

  1. pmc Revised nomenclature for avian telencephalon and some related brainstem nuclei
    Anton Reiner
    Department of Anatomy, University of Tennessee Health Science Center, Memphis 38163, USA
    J Comp Neurol 473:377-414. 2004
    ..In particular, the outdated terminology implies that most of the avian telencephalon is a hypertrophied basal ganglia, when it is now clear that most of the avian telencephalon is neurochemically,..
  2. ncbi Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon
    Teresa Giraldez
    Unidad de Farmacologia, Universidad de La Laguna, La Laguna, Tenerife, Spain
    J Neurochem 102:1304-15. 2007
    ..the expression pattern of both the known (delta1) and the new (delta2) isoforms in the human and monkey telencephalon. ENaC delta2 is produced by a combination of alternative transcription start sites, a frame shift in exon 3 ..
  3. ncbi Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
    ..The expression of these molecules is also affected in the entorhinal, the visual and the somatosensory cortices...
  4. ncbi The origin and specification of cortical interneurons
    Carl P Wonders
    Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York 10021, USA
    Nat Rev Neurosci 7:687-96. 2006
    ..Here, we discuss recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons...
  5. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
    ..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer...
  6. pmc A high-resolution enhancer atlas of the developing telencephalon
    Axel Visel
    Genomics Division, MS 84 171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cell 152:895-908. 2013
    The mammalian telencephalon plays critical roles in cognition, motor function, and emotion...
  7. pmc Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis
    Wulf Haubensak
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 101:3196-201. 2004
    ..Basal progenitors are most frequent in the telencephalon, where they outnumber the apically dividing neuron-generating NE cells...
  8. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum)...
  9. ncbi Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures
    J M Hebert
    Department of Biological Sciences, Stanford University, Stanford, California, 94305 5020, USA
    Dev Biol 222:296-306. 2000
    The use of genetics to study the development of the telencephalon and derivatives such as the cerebral cortex has been limited...
  10. ncbi Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon
    Martin März
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
    Glia 58:870-88. 2010
    ..In the telencephalon, this complexity is enhanced by an organization of the ventricular zone (VZ) in fast and slow-dividing domains,..
  11. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992
    ..Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation...
  12. pmc Mechanisms of inhibition within the telencephalon: "where the wild things are"
    Gord Fishell
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    Annu Rev Neurosci 34:535-67. 2011
    ..of the diversity and mechanisms by which GABAergic interneuron populations function in different parts of the telencephalon. This is followed by a summary of the mechanisms of inhibition in the CNS...
  13. ncbi Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon
    Birgit Adolf
    Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    Dev Biol 295:278-93. 2006
    ..Using BrdU tracing and immunodetection of cell-type-specific markers, we demonstrate that the adult zebrafish telencephalon contains self-renewing progenitors, which show features of adult mammalian neural stem cells but distribute ..
  14. ncbi Fate mapping Nkx2.1-lineage cells in the mouse telencephalon
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 506:16-29. 2008
    The homeodomain transcription factor Nkx2.1 is expressed in the pallidal (subcortical) telencephalon, including the medial ganglionic eminence (MGE) and preoptic area. Studies have shown that Nkx2...
  15. ncbi Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
    Mattias Backman
    Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, University of Oslo, The National Hospital, 0027 Oslo, Norway
    Dev Biol 279:155-68. 2005
    ..In this study, we used conditional Cre/loxP system in mouse to ablate or activate beta-catenin in the telencephalon in two time windows: before and after the onset of neurogenesis...
  16. ncbi Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice
    Takuji Iwasato
    PRESTO, Japan Science and Technology Agency, Saitama, Japan
    Genesis 38:130-8. 2004
    ..we report the isolation of a DNA fragment containing the Emx1 gene promoter, which is responsible for dorsal telencephalon-specific expression...
  17. ncbi Regenerative response following stab injury in the adult zebrafish telencephalon
    Martin März
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Dev Dyn 240:2221-31. 2011
    ..We analyzed the proliferation of glial cells and microglia in response to stab injury in the adult zebrafish telencephalon: Radial glial markers were up-regulated at the ventricle and co-expressed the proliferation nuclear antigen (..
  18. ncbi Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis
    Emily Violette Baumgart
    Institute for Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Glia 60:343-57. 2012
    ..astrocytes, we examined the glial response to an invasive stab wound injury model in the adult zebrafish telencephalon. Strikingly, already a few days after injury the wound was closed without any scar tissue...
  19. ncbi Migration of neuronal precursors from the telencephalic ventricular zone into the olfactory bulb in adult zebrafish
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Comp Neurol 519:3549-65. 2011
    ..Taken together, our results suggest that the RMS in the adult zebrafish telencephalon is a functional migratory pathway...
  20. ncbi Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes
    S A Anderson
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
    Science 278:474-6. 1997
    ..zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical ..
  21. ncbi Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
    Null mutation of the Foxg1 gene causes hypoplasia of the mouse telencephalon and loss of ventral telencephalic structures. We show that a crucial early requirement for Foxg1 is in the induction of ventral cell fate in the telencephalon...
  22. ncbi Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate
    Ina Rothenaigner
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, Institute of Neurobiology Alfred Fessard, Avenue de la Terrasse, Gif sur Yvette Cedex, France
    Development 138:1459-69. 2011
    ..These results characterize fundamental aspects of adult progenitor cells and neurogenesis, and open the way to using virus-based technologies for stable genetic manipulations and clonal analyses in the zebrafish adult brain...
  23. ncbi Convergence of olfactory and vomeronasal projections in the rat basal telencephalon
    Palma Pro-Sistiaga
    Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, 02006 Albacete, Spain
    J Comp Neurol 504:346-62. 2007
    ..projections have been traditionally viewed as terminating in contiguous non-overlapping areas of the basal telencephalon. Original reports, however, described areas such as the anterior medial amygdala where both chemosensory ..
  24. ncbi Expression of the transcription factor Olig2 in proliferating cells in the adult zebrafish telencephalon
    Martin März
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Dev Dyn 239:3336-49. 2010
    The telencephalon of the adult zebrafish is highly proliferative: Dividing cells are found along the entire ventricular zone and in the parenchyma...
  25. ncbi MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 129:4483-95. 2002
    ..MUK/DLK/ZPK, and JNK activity increase potently and temporally in newly generated neurons in developing mouse telencephalon during radial migration...
  26. ncbi Notch3 signaling promotes radial glial/progenitor character in the mammalian telencephalon
    Louis Dang
    Institute for Cell Engineering, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Neurosci 28:58-69. 2006
    ..Previous work in the mouse telencephalon has shown that activated Notch1 promotes radial glial and astrocytic character in vivo, and fibroblast growth ..
  27. ncbi Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility
    I Zipancic
    Department of Cell Therapy and Regenerative Medicine, Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain
    Cell Transplant 19:549-64. 2010
    ....
  28. ncbi Doublecortin expression in the adult rat telencephalon
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 14:629-44. 2001
    ..Given these results, we hypothesize that DCX expression in differentiated neurons could be related to its capacity for microtubule reorganization and that this fact could be linked to axonal outgrowth or synaptogenesis...
  29. ncbi Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon
    Shengxi Wu
    Department of Morphological Neural Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556 Japan
    Development 138:2499-509. 2011
    ..Therefore, they must migrate tangentially within the telencephalon to reach the neocortex...
  30. pmc The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development
    Jingyang Zhong
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Development 138:409-19. 2011
    GABAergic neurons and oligodendrocytes originate from progenitors within the ventral telencephalon. However, the molecular mechanisms that control neuron-glial cell-fate segregation, especially how extrinsic factors regulate cell-fate ..
  31. ncbi Prokineticin 2 expression is associated with neural repair of injured adult zebrafish telencephalon
    Besma Ayari
    Centre de Recherche de l Institut du Cerveau et de la Moelle épinière CRICM, 75651 Paris Cedex, France
    J Neurotrauma 27:959-72. 2010
    ..to analyze the distribution of PROK2 transcripts in the adult zebrafish brain and during injury-induced telencephalon (TC) regeneration...
  32. pmc Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon
    Jan Mulder
    European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen, UK
    Eur J Neurosci 31:2166-77. 2010
    ..that scgn may be expressed by particular neuronal contingents during prenatal development of the mammalian telencephalon. We find that scgn is expressed in neurons transiting in the subpallial differentiation zone by embryonic day (..
  33. pmc Regulation of mouse embryonic stem cell neural differentiation by retinoic acid
    Mijeong Kim
    Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 328:456-71. 2009
    ..Transcriptional profiling indicates a substantial representation of transit amplifying neuroblasts in SFD cultures not exposed to RA...
  34. ncbi Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis
    Jan Stenman
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Neurosci 23:167-74. 2003
    ..In support of this, mice mutant for the homeobox genes Gsh2 and Gsh1/2, which show olfactory bulb defects, exhibit dramatically reduced numbers of Er81-positive cells in the LGE SVZ as well as in the olfactory bulb mantle...
  35. ncbi Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage
    Jessica A Gorski
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 22:6309-14. 2002
    ..Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells...
  36. ncbi Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Glia 58:1345-63. 2010
    ..To understand the components of the progenitor zones in the adult zebrafish telencephalon and the link between glial characteristics and progenitor state, we examined whether canonical glial markers ..
  37. ncbi A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei
    Fernando García-Moreno
    Instituto Cajal Consejo Superior de Investigaciones Cientificas, Laboratory of Telencephalic Development, Molecular, Cellular and Developmental Neurobiology Department, Madrid, Spain
    Nat Neurosci 13:680-9. 2010
    ..The diencephalic transcription factor OTP was necessary for this migratory behavior...
  38. ncbi MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors
    Mikihito Shibata
    Laboratories for Vertebrate Body Plan and Animal Resources and Genetic Engineering, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0047, Japan
    J Neurosci 31:3407-22. 2011
    ..that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors...
  39. ncbi The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Biol Chem 281:13374-81. 2006
    ..2nd intronic enhancer, the SRR2 shows strong regional specificity functioning only in restricted areas of the telencephalon but not in any other portions of the central nervous system such as the spinal cord...
  40. ncbi Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells
    Prisca Chapouton
    Zebrafish Neurogenetics Department, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Neurosci 30:7961-74. 2010
    ..We use here the germinal zone of the zebrafish adult telencephalon to examine how the frequency of NSC divisions is regulated...
  41. pmc Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon
    Janet E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 19:i144-51. 2009
    ..along the lateral thalamic surface, and as they approach hypothalamus make a lateral turn into ventral telencephalon. In vitro studies show that hypothalamus releases a chemorepellent for TCAs, and analyses of knockout mice ..
  42. ncbi Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)
    S Tole
    Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637, USA
    Dev Biol 217:254-65. 2000
    Little is known about the mechanisms that control the development of regional identity in the mammalian telencephalon. The Gli family of transcription factor genes is involved in the regulation of pattern at many sites in the embryo and ..
  43. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  44. ncbi Directed differentiation of telencephalic precursors from embryonic stem cells
    Kiichi Watanabe
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Nat Neurosci 8:288-96. 2005
    ..Thus, in the absence of caudalizing signals, floating aggregates of ES cells generate naive telencephalic precursors that acquire subregional identities by responding to extracellular patterning signals...
  45. ncbi Aggression and vasotocin are associated with dominant-subordinate relationships in zebrafish
    Earl T Larson
    Department of Psychology, Northeastern University, Boston, MA 02115, USA
    Behav Brain Res 167:94-102. 2006
    ..These results suggest that the vasotocinergic system may play a role in shaping dominant-subordinate relationships and agonistic behavior in this model organism...
  46. ncbi Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Development 135:2531-41. 2008
    ....
  47. pmc Identification of a brain center whose activity discriminates a choice behavior in zebrafish
    Billy Y B Lau
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143 2811, USA
    Proc Natl Acad Sci U S A 108:2581-6. 2011
    ..Based on these findings and previous connectivity data, we propose a neural circuitry model in which the Dm serves as a brain center, the activity of which predicates this choice behavior in zebrafish...
  48. ncbi Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors
    Keejung Yoon
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:9497-506. 2004
    ....
  49. pmc Social context-induced song variation affects female behavior and gene expression
    Sarah C Woolley
    Department of Psychiatry, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 6:e62. 2008
    ..Together these data demonstrate that females detect and prefer the features of directed song and suggest that high-level auditory areas including the CMM are involved in this social perception...
  50. ncbi Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon
    J R Menezes
    Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322
    J Neurosci 14:5399-416. 1994
    ..and morphology of immature neurons in the proliferative ventricular and subventricular zones of the developing telencephalon. Mouse brains from embryonic day 12 (E12) to postnatal day 5 (P5) were fixed either with a non-cross-linking ..
  51. ncbi Connections of the lateral and medial divisions of the goldfish telencephalic pallium
    R Glenn Northcutt
    Neurobiology Unit, Scripps Institution of Oceanography, and Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California 92093 0201, USA
    J Comp Neurol 494:903-43. 2006
    ..The topography and connections of Dl are remarkably similar to those of the hippocampus of tetrapods, whereas the topography and connections of Dm are similar to those of the amygdala...
  52. ncbi Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine
    Cameron S McPherson
    Howard Florey Institute, University of Melbourne, Parkville, 3010 Victoria, Australia
    Cereb Cortex 20:941-52. 2010
    ..We conclude that there is a specific role for CREB1 in telencephalic glutamatergic neurons regulating the motivational properties of cocaine...
  53. ncbi Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon
    Kyuson Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, Box 0984, 94143 0984, USA
    Development 129:5029-40. 2002
    ..We suggest that alternate cell fate choices in the developing telencephalon are controlled by coordinated functions of bHLH and homeobox transcription factors through their differential ..
  54. ncbi Subdivisions of the adult zebrafish subpallium by molecular marker analysis
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany
    J Comp Neurol 520:633-55. 2012
    The morphology of the telencephalon displays great diversity among different vertebrate lineages...
  55. pmc Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon
    Tomasz Jan Nowakowski
    Developmental Biology Laboratory, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e23013. 2011
    ..for the generation of mature micro RNAs, by conditionally mutating the Dicer1 gene in the early embryonic telencephalon and analyse the molecular specification of radial glia as well as their progeny, namely postmitotic neurons ..
  56. ncbi Sex differences in the dorsolateral telencephalon correlate with home range size in blenniid fish
    Silvia S Costa
    Eco Ethology Research Unit, ISPA Instituto Universitário, Lisbon, Portugal
    Brain Behav Evol 77:55-64. 2011
    ..Since the dorsolateral telencephalon has been considered a teleost homologue of the mammalian hippocampus, we predicted that the spatial abilities ..
  57. ncbi Effect of MK-801-induced impairment of inhibitory avoidance learning in zebrafish via inactivation of extracellular signal-regulated kinase (ERK) in telencephalon
    Ming Chong Ng
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    Fish Physiol Biochem 38:1099-106. 2012
    ..These results suggest that the formation of long-term emotional memory is possibly mediated by ERK activation in the telencephalon of zebrafish.
  58. ncbi Gli3 is required for Emx gene expression during dorsal telencephalon development
    T Theil
    Institute for Molecular Biology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany thomas
    Development 126:3561-71. 1999
    ..To date, only Emx genes were known to be required for dorsal telencephalon development...
  59. pmc The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei)
    Thomas Mueller
    Department of Bioengineering and Therapeutic Sciences and Programs in Human Genetics, University of California, San Francisco, CA 94143 2811, USA
    Brain Res 1381:95-105. 2011
    ..nicotine adenine dinucleotide phosphate diphorase (NADPHd) activity and parvalbumin in the anterior zebrafish telencephalon, we show that against previous assumptions the central (Dc) zone possesses its own germinative region in the ..
  60. pmc Cytoarchitecture of a cichlid fish telencephalon
    Sabrina S Burmeister
    Department of Biology and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Brain Behav Evol 74:110-20. 2009
    Although the telencephalon of ray-finned fishes has garnered considerable attention from comparative neuroanatomists, detailed descriptions of telencephalic organization are available for only a few species...
  61. ncbi Cytoarchitectonic study of the brain of a perciform species, the sea bass (Dicentrarchus labrax). I. The telencephalon
    J M Cerdá-Reverter
    Department of Reproductive Physiology of Fish, Instituto de Acuicultura de Torre de la Sal, CSIC, Ribera de Cabanes, Castellon, Spain
    J Morphol 247:217-28. 2001
    A cytoarchitectonic analysis of the telencephalon of the sea bass Dicentrarchus labrax, based on cresyl violet-stained serial transverse sections, is presented...
  62. pmc Neuronal regeneration in a zebrafish model of adult brain injury
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Dis Model Mech 5:200-9. 2012
    ..Recent studies show that neurogenesis in the ventricular zone (VZ) of the adult zebrafish telencephalon has features in common with neurogenesis in the adult mammalian SVZ...
  63. ncbi SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon
    Scott R Hutton
    Department of Genetics, University of North Carolina, 115 Mason Farm Rd, CB 7250, Chapel Hill, NC 27599, USA
    Dev Biol 352:40-7. 2011
    ..In the developing dorsal telencephalon, two distinct populations of neural progenitors, radial glia and intermediate progenitor cells, are ..
  64. ncbi Phenotypic expression of monoamines and GABA in the early development of human telencephalon, transient or not transient
    Catherine Verney
    Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, 75019, Paris, France
    J Chem Neuroanat 26:283-92. 2003
    ..such as tyrosine-hydroxylase (TH) immunoreactivity in various neuronal populations of the developing human telencephalon. The specific transporter for serotonin, serotonin transporter (SERT) has been detected in fibers of the ..
  65. pmc The development and general morphology of the telencephalon of actinopterygian fishes: synopsis, documentation and commentary
    Rudolf Nieuwenhuys
    The Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Brain Struct Funct 215:141-57. 2011
    ..The telencephalon of actinopterygian fishes differs from that in all other vertebrates in that it consists of a pair of solid ..
  66. ncbi Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
    Cortical GABAergic neurons originate in the ventral telencephalon, invade the cortex via tangential migration, and integrate into the cortical plate by surface-directed and ventricle-directed migration...
  67. pmc A genomic atlas of mouse hypothalamic development
    Tomomi Shimogori
    RIKEN BSI, 2 1 Hirosawa, Wako Shi, Saitama, Japan
    Nat Neurosci 13:767-75. 2010
    ..Our results serve as a resource for functional investigations of hypothalamic development, connectivity, physiology and dysfunction...
  68. ncbi Induction and patterning of the telencephalon in Xenopus laevis
    Giuseppe Lupo
    Dipartimento di Fisiologia e Biochimica, Laboratorio di Biologia Cellulare e dello Sviluppo, Universita di Pisa, via G Carducci 13, 56010 Ghezzano Pisa, Italy
    Development 129:5421-36. 2002
    ..Therefore, integration of organizer secreted molecules and of FGF, may account for patterning of the more rostral part of Xenopus CNS...
  69. pmc Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon
    Vanessa Gil
    Molecular and Cellular Neurobiotechnology laboratory, Institute for Bioengineering of Catalonia IBEC, Barcelona E 08028, Spain
    Cereb Cortex 20:1769-79. 2010
    ..Our data support the idea that early expressed MAIPs play an active role during development and point to OMgp participating in thalamo-cortical connections...
  70. pmc Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 45:208-17. 2007
    ..thereafter the chorion, in addition to the visceral endoderm and primitive streak at gastrula stages, and the telencephalon at later stages...
  71. pmc Seasonal neuroplasticity in the songbird telencephalon: a role for melatonin
    G E Bentley
    Department of Psychology, Behavioral Neuroendocrinology Group, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 96:4674-9. 1999
    ..This effect was observed regardless of reproductive state. To our knowledge, this is the first direct evidence of a role for melatonin in functional plasticity within the central nervous system of vertebrates...
  72. ncbi Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells
    Hiromi Takanaga
    Center for Developmental Biology, RIKEN, Kobe, Japan
    Stem Cells 27:165-74. 2009
    ..Thus these data reveal a novel transcriptional cascade, involving Gli2 --> Sox2 --> Hes5, which maintains the undifferentiated state of telencephalic NE cells...
  73. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..We sketch a simplified model, in which the secondary prosencephalon (telencephalon plus hypothalamus) is a complex protosegment not subdivided into prosomeres, which exhibits patterning ..
  74. ncbi Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon
    E M Powell
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuron 30:79-89. 2001
    Cortical interneurons arise from the proliferative zone of the ventral telencephalon, the ganglionic eminence, and migrate into the developing neocortex...
  75. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ..In the telencephalon, the Ngns and Mash1 are expressed at high levels in complementary dorsal and ventral domains, respectively...
  76. ncbi Zinc-containing neurons are distinct from GABAergic neurons in the telencephalon of the rat
    L Slomianka
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands
    Anat Embryol (Berl) 195:165-74. 1997
    ..Other strongly calbindin-immunoreactive neurons of the telencephalon were never double-labeled...
  77. ncbi Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    Joan Seoane
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 1300 York Avenue, New York, NY 1002, USA
    Cell 117:211-23. 2004
    ..We suggest that the activity of this network confers resistance to TGF-beta-mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells...
  78. ncbi Emx1 and Emx2 functions in development of dorsal telencephalon
    M Yoshida
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
    Development 124:101-11. 1997
    ..In the more lateral region of telencephalon, Emx2-deficiency may be compensated for by Emx1 and vice versa...
  79. pmc FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation
    Martin Roth
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 137:1553-62. 2010
    ..transcriptional repressor that plays a key role in the specification, proliferation and differentiation of the telencephalon, and is expressed from the earliest stages of telencephalic development through to the adult...
  80. pmc Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus
    Tianyu Zhao
    Department of Genes and Behavior, Brain Development Group, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Eur J Neurosci 28:1941-55. 2008
    ..The expanded neuroepithelium generates abundant neurons for the medial hypothalamus at the tuberal level. Finally, we have uncovered novel diencephalon-to-telencephalon migrations into septum, piriform cortex and amygdala.
  81. ncbi Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Sweden
    Mech Dev 94:183-7. 2000
    ..Curr. Opin. Genet. Dev. 8, 423-429). We have studied the expression of these genes in the mouse telencephalon and found that Meis1 and Meis2 display region-specific patterns of expression from embryonic day (E)10...
  82. ncbi Transformation of odor representations in target areas of the olfactory bulb
    Emre Yaksi
    Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 12:474-82. 2009
    ..This mechanism can extract information about combinations of molecular features from ensembles of active and inactive mitral cells, suggesting that pattern processing in Dp establishes representations of odor objects...
  83. ncbi Effects of songs and calls on ZENK expression in the auditory telencephalon of field- and isolate-reared black capped chickadees
    Leslie S Phillmore
    Department of Psychology, Queen s University, Kingston ON, Canada K7L 3N6
    Behav Brain Res 147:125-34. 2003
    ..These findings indicated that the type of conspecific vocalization, as well as the sex of the listener, appear to modulate IEG expression in the songbird ascending auditory pathway...
  84. ncbi Expression of the genes Emx1, Tbr1, and Eomes (Tbr2) in the telencephalon of Xenopus laevis confirms the existence of a ventral pallial division in all tetrapods
    Aurora Brox
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 474:562-77. 2004
    ..xTbr1) gene and analyzed its expression compared with that of the genes xEomes (Tbr2) and xEmx1 in the telencephalon of the frog Xenopus laevis during embryonic and larval development...
  85. ncbi Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Stroke 38:3032-9. 2007
    ..We explored whether MCAO leads to hypoxia, changes in vessel density, and angiogenesis in the ipsilateral SVZ and adjacent striatum, and determined the relation between the migrating neuroblasts and the vasculature...
  86. ncbi LRP2/megalin is required for patterning of the ventral telencephalon
    Robert Spoelgen
    Max Delbrueck Center for Molecular Medicine, Berlin, 13092, Germany
    Development 132:405-14. 2005
    ..Because megalin mediates endocytic uptake and degradation of BMP4, these findings indicate a role for megalin in neural tube specification, possibly by acting as BMP4 clearance receptor in the neuroepithelium...
  87. ncbi Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain
    T Ohtsuka
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 276:30467-74. 2001
    ..These results indicate that Hes1 and Hes5 play an important role in the maintenance of neural stem cells but not in gliogenesis in the embryonal telencephalon.
  88. ncbi The dopaminergic innervation of the avian telencephalon
    D Durstewitz
    AE Biopsychologie, Ruhr Universitat Bochum, Germany
    Prog Neurobiol 59:161-95. 1999
    ..provides an overview of the distribution of dopaminergic fibers and dopaminoceptive elements within the avian telencephalon, the possible interactions of dopamine (DA) with other biochemically identified systems as revealed by ..
  89. pmc Laminar and columnar auditory cortex in avian brain
    Yuan Wang
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92093 0608, USA
    Proc Natl Acad Sci U S A 107:12676-81. 2010
    ..methods, we demonstrate the existence of comparable columnar functional modules in laminated auditory telencephalon of an avian species (Gallus gallus)...
  90. ncbi The temporal and spatial origins of cortical interneurons predict their physiological subtype
    Simon J B Butt
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Neuron 48:591-604. 2005
    ..At present, little is known about how these neurons are specified in the developing telencephalon. To explore whether this diversity is established in the early progenitor populations, we conducted in utero ..
  91. pmc Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior
    Giuliana Caronia
    Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 30:6291-301. 2010
    ..mice that were deficient in Bmpr1b constitutively, and deficient in Bmpr1a conditionally in the dorsal telencephalon. In double mutant male and female mice, the dentate gyrus (DG) was dramatically smaller than in control mice, ..
  92. pmc Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis
    Joseph A Nielsen
    Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    BMC Neurosci 10:98. 2009
    ....
  93. pmc Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon
    Ashton W Powell
    Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Biol 6:e116. 2008
    ..topography of thalamocortical (TC) axon projections is initiated before they reach the cortex, in the ventral telencephalon (VTel)...
  94. ncbi Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1
    Catherine Danesin
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, UK
    Dev Cell 16:576-87. 2009
    ..Concomitantly to these roles, Foxg1 controls the formation of the compartment boundary between telencephalon and basal diencephalon...
  95. ncbi Anatomical distribution and cellular basis for high levels of aromatase activity in the brain of teleost fish: aromatase enzyme and mRNA expression identify glia as source
    P M Forlano
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 21:8943-55. 2001
    ..activity in a vocal fish, the plainfin midshipman (Porichthys notatus), and found highest levels in the telencephalon and lower levels in the sonic hindbrain, which was dimorphic between and within (males) sexes...
  96. ncbi LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem
    S Bulchand
    Department of Biological Sciences, Tata Institute of Fundamental Research, 400005, Mumbai, India
    Mech Dev 100:165-75. 2001
    We are interested in the early mechanisms that initiate regional patterning in the dorsal telencephalon, which gives rise to cerebral cortex...
  97. ncbi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
    ..evidence that the Notch-Delta pathway plays an important role in this selection in the developing mouse telencephalon. We found that the expression patterns of the Notch ligand delta-like 1 (Dll1) and of the active form of ..
  98. ncbi The cellular fate of cortical progenitors is not maintained in neurosphere cultures
    Ondrej Machon
    Institute of Molecular Genetics, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic
    Mol Cell Neurosci 30:388-97. 2005
    ..We isolated neural progenitors from the dorsal telencephalon of D6-GFP mice and cultured them in vitro...
  99. pmc Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon
    Alexandra A Gulacsi
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, New York, 10065, USA
    Nat Neurosci 11:1383-91. 2008
    Development of the telencephalon involves the coordinated growth of diversely patterned brain structures...
  100. ncbi Fibroblast growth factor 8 regulates neocortical guidance of area-specific thalamic innervation
    Tomomi Shimogori
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:6550-60. 2005
    ..Our findings demonstrate that thalamocortical axons are directed by sequential, positional cues within the cortex and implicate FGF8 as an indirect regulator of thalamocortical innervation...
  101. ncbi Connections of the ventral telencephalon (subpallium) in the zebrafish (Danio rerio)
    Elke Rink
    Brain Research Institute, University of Bremen, 28334, Bremen, Germany
    Brain Res 1011:206-20. 2004
    Connections of the medial precommissural subpallial ventral telencephalon, i.e...

Research Grants64

  1. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  2. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
    ..Results suggested that BF-1 was essential for growth of the telencephalon because at early stages, no significant differences in size of the telencephalic vesicles were apparent...
  3. TECTOPULVINAR SYSTEM: MOTION DETECTION AND EVOLUTION
    Harvey Karten; Fiscal Year: 2004
    ..suggest that the tectopulvinar system is one of the most ancient components of the ascending pathways to the telencephalon and is vital to the process of motion detection...
  4. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  5. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  6. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2012
    ..These GnRH neurons originate outside the CNS and migrate into the ventral telencephalon and hypothalamus during embryogenesis...
  7. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Michael W Miller; Fiscal Year: 2010
    ..These derive prenatally from two distinct proliferative regions. PNs come from the dorsal telencephalon which comprises two zones: the ventricular zone (VZ) and its derivative, the subventricular zone (SZ)...
  8. Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase
    Biplab Dasgupta; Fiscal Year: 2013
    ..it is known that humoral and transcriptional regulation generates the cellular diversity in the mammalian telencephalon, a relatively unexplored area is whether the progenitor populations are also metabolically distinct and the ..
  9. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Frank A Middleton; Fiscal Year: 2013
    ..These derive prenatally from two distinct proliferative regions. PNs come from the dorsal telencephalon which comprises two zones: the ventricular zone (VZ) and its derivative, the subventricular zone (SZ)...
  10. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  11. Roles of Gsh1 &Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2012
    The mammalian telencephalon represents the region of the brain that displays the most cellular diversity, particularly with respect to neuronal subtypes...
  12. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
    ..to cocaine during the major periods of cortical (pallium) and limbic system (dorsomedial and dorsolateral telencephalon) development, synchronized with either the nighttime or daytime circadian phase...
  13. Origin of Cortical Species-specific Distinctions
    Pasko Rakic; Fiscal Year: 2012
    ..on the initial stages of cortical development in the rodent (mouse), non-human primate (macaque) and human telencephalon by using the most advanced genetic molecular and in vitro and in vivo cell biological methods available...
  14. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy B Macklin; Fiscal Year: 2013
    ..for migration of neurons and oligodendrocyte progenitor cells in cerebellum, optic nerve and embryonic telencephalon, using real time imaging...
  15. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2013
    ..The embryonic basal telencephalon generates subcortical nuclei and cortical interneurons that are required for the function of these circuits...
  16. ROLE OF THE CORTICAL HEM IN PATTERNING THE TELENCEPHALON
    Elizabeth Ann Grove; Fiscal Year: 2013
    ..Together these studies should clarify normal development of the cerebral cortex, and shed light on the possible causes of human cortical malformations. ..
  17. Fate Determination of Interneruons in the Mammalian Telecephalon
    Stewart A Anderson; Fiscal Year: 2013
    ..This mouse will permit fate-mapping of cells that originated within a subregion of the subcortical telencephalon, the medial ganglionic eminence and preoptic area...
  18. NEURAL MECHANISMS OF ANOREXIA
    Alan G Watts; Fiscal Year: 2012
    ..Inparticular,studieswillfocusoninteractionsbetweenthetelencephalon,andthehypothalamus and hindbrain, since the telencephalon likely plays a critical role in clinically-relevant anorexias...
  19. Understanding the role of Fezl in adult neural stem cell maintenance and fate
    MICHAEL ARMAN BERBEROGLU; Fiscal Year: 2012
    ..have established that Fezl is expressed in self-renewing ventricular progenitor cells of the adult zebrafish telencephalon. To determine whether these Fezl-expressing cells are multipotent and can give rise to both neurons and glial ..
  20. NEUROPEPTIDES AND THEIR PHYSIOLOGICAL CONTROL
    Alan G Watts; Fiscal Year: 2013
    ..they also help the PVH to coordinate neuroendocrine and autonomic responses with responses generated by the telencephalon. The pre-motor network is proposed to actively and dynamically controls the level of CRH synthesis and release,..
  21. The Autonomous Roles of Periventricular Angiogenesis in the CNS
    Anju Vasudevan; Fiscal Year: 2013
    ..The pial vessels do not display developmental gradients and are present circumscribing the entire telencephalon by embryonic day 9 (E9)...
  22. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John L R Rubenstein; Fiscal Year: 2013
    ..abstract_text> ..
  23. Ctip2 Function in Corticospinal Motor Neuron Development
    MOLLIE BURGOON WOODWORTH; Fiscal Year: 2012
    ..During the development of the mammalian telencephalon, spatially and temporally heterogeneous progenitor cells generate a rich variety of projection neuron subtypes...
  24. SHH signaling and Interneuron progenitors in human subventricular zone
    NADA R ZECEVIC; Fiscal Year: 2012
    ..to rodents where cortical interneurons mainly originate in the ganglionic eminence (GE) of the ventral telencephalon, in primates they can originate in the GE and in the cortical oSVZ...
  25. A Role for Serotonin in the Production and Learning of Song
    William Wood; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Serotonin (5-HT) is a neuromodulator widely expressed in the telencephalon and involved in modulating a number of complex behaviors including learning, emotional state, aggression, and sleep...
  26. Clonal Analysis of Neocortical Interneuron Circuit Development
    Song Hai Shi; Fiscal Year: 2011
    ..innovative methods for effectively and selectively labeling interneuron progenitor cells in the ventral telencephalon - the ganglionic eminences - at clonal density...
  27. Genetic analysis of forebrain patterning and neurogenesis
    Jean M Hebert; Fiscal Year: 2013
    ..our preliminary data indicate that FRS is only required for certain aspects of FGF signaling in early telencephalon development...
  28. Embryonic Vascular Networks and GABA Neuron Migration
    Anju Vasudevan; Fiscal Year: 2010
    GABAergic interneurons, born in remote germinative zones in the ventral forebrain (telencephalon) migrate tangentially into the cortex to adopt their specific positions...
  29. Cellular Mechanisms for Oligodendrocyte Myelination
    Bruce D Trapp; Fiscal Year: 2010
    ..a better understanding of how multipotent CNS stem cells located in the subventricular zone (SVZ) of the telencephalon produce OPCs in response to demyelination...
  30. WNTs, FGFs, and BMPs Induce and Maintain the Telencephalon
    Jean M Hebert; Fiscal Year: 2013
    ..results in loss of telencephalic markers in zebrafish, indicating that low WNT signaling is necessary for telencephalon induction. In mice, it remains unclear if low WNT signaling is necessary for telencephalon induction...
  31. Functional Organization of the Song Motor Control System
    Marc F Schmidt; Fiscal Year: 2012
    ..relatively simple rhythmic motor patterns, models of motor control often place most of their emphasis on the telencephalon. This is certainly true for the production of learned vocal behaviors where the brainstem is viewed primarily ..
  32. Genetic analysis of chandelier cells during cortical circuit assembly
    Z Josh Huang; Fiscal Year: 2013
    ..has made in understanding the early development of cortical interneurons, from their generation in the ventral telencephalon to their long distance migration into the cortex, it is still unclear how distinct classes of interneuron are ..
  33. Development of the basal telencephalic limbic system
    MOLLY MAUREEN HUNTSMAN; Fiscal Year: 2013
    ..Our previous studies have identified distinct progenitor pools in the developing telencephalon that contribute to postnatal neuronal cell diversity in these amygdala subdivisions...
  34. Functional integration of inhibitory interneuron progenitors in the adult brain
    Robert F Hunt; Fiscal Year: 2013
    ..the effect of inhibitory neural progenitor cell subtypes derived from other regions of the embryonic telencephalon on existing host circuitry remains largely unknown, especially after transplant into the adult brain...
  35. LEWIS X OLIGOSACCHARIDE IN THE EMBRVONIC CNS
    Paul Patterson; Fiscal Year: 1999
    ..It's pattern of labeling delineates a novel set of boundaries in the rodent telencephalon and diencephalon, displaying a partial overlap with the expression of the transcription factor BF- 1...
  36. Specifying the Neocortical Area Map in the Ferret
    Elizabeth Ann Grove; Fiscal Year: 2013
    ..In the mouse telencephalon, a rostral patterning center (RPC) releases Fibroblast Growth Factor (FGF) 8, a morphogen that disperses in a ..
  37. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..and FGF2 transgenic mice with regard to volume, cell number and apoptosis within histogenic domains of the telencephalon containing neuronal and glial progenitor cells...
  38. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2005
    ..each of these broadly defined functions, and has shown that they-along with closely associated limbic telencephalon regions-project topographically to the lateral hypothalamic area (LHA)...
  39. EVOLUTION OF THE TELENCEPHALON
    RICHARD NORTHCUTT; Fiscal Year: 1993
    ..application, a plan is outlined for continuing studies on the organization and evolution of the vertebrate telencephalon. Living vertebrates constitute two major evolutionary radiations: jawless fishes (agnathans) and jawed ..
  40. DEVELOPMENT AND MIGRATION OF LHRH NEURONS
    Robert Norgren; Fiscal Year: 1999
    ..have demonstrated that X-linked Kallmann's disease is due to a failure of the olfactory nerve to enter the telencephalon and LHRH neurons to migrate into the brain...
  41. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John L R Rubenstein; Fiscal Year: 2013
    ..from the rostral patterning center plays a major role in governing growth and patterning of the rostral telencephalon, including the frontal cortex...
  42. Generation of Cortical Motoneurons from Embryonic Stem Cells
    Xue Jun Li; Fiscal Year: 2007
    ..be assessed by their interaction with lower motoneurons in culture and following transplantation to dorsal telencephalon of a chick embryo...
  43. LATERAL LINE PATHWAYS
    ROBERT BOORD; Fiscal Year: 1991
    ..reveal that the mesencephalic electrosensory lateral line nucleus projects to the medial pallium of the telencephalon via a posterior lateral thalamic relay center...
  44. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  45. The Role of FoxP2 in Olfactory Bulb Interneuron Neurogenesis
    Zegary J Allen; Fiscal Year: 2010
    ..factors Pax6 and Gsh2 are required for proper development of dorsal-ventral patterning in the embryonic telencephalon while Sp8 and Mashl play important roles in olfactory bulb interneuron generation...
  46. NEUROTROPHINS IN OLFACTORY DEVELOPMENT
    Kathleen Guthrie; Fiscal Year: 2002
    ..At this time, cells in the rostral telencephalon express the appropriate tyrosine kinase trk receptors for these neurotrophins and the olfactory bulbs begin to ..
  47. ELIMINATION OF RADIAL GLIA IN POSTNATAL TELENCEPHALON
    JOAO MENEZES; Fiscal Year: 2004
    ..Initially, we will focus on the proliferative and migratory activity that occurs in the postnatal subventricular zone, where most of the cell bodies of the radial glial cells are found at this stage. ..
  48. DUAL OLFACTORY SYSTEM--STRUCTURE/FUNCTION
    Mimi Halpern; Fiscal Year: 2003
    ..The dual olfactory system hypothesis postulates that these two systems comprise parallel pathways through the telencephalon and, by virtue of these connections, are involved in different aspects of behavioral response to chemical ..
  49. THE ONCOGENICITY OF WINGED HELIX PROTEINS
    Peter Vogt; Fiscal Year: 2003
    ..The proteins to be studied are Qin, a telencephalon-specific protein that is also expressed as the oncogenic determinant in a retrovirus, CWH2, a mutant form of ..
  50. OLFACTORY AXON REGULATE OLFACTORY BULB CYTOGENESIS
    Qizhi Gong; Fiscal Year: 2003
    ..this application are designed to examine the mechanisms by which olfactory axons interact with the developing telencephalon to regulate neurogenesis in the olfactory bulb primordium that develops from the rostral end of the ..
  51. Developmental Differences in Brain Androgen Synthesis
    Sarah London; Fiscal Year: 2004
    ..been seen in transcriptional levels of 17 alpha hydroxylase (CYP 17), the enzyme that makes androgen, in the telencephalon of developing zebra finches...
  52. Regulation of Tangential Migration in the Embryonic CNS
    Andrew Peterson; Fiscal Year: 2004
    ..will also be examined using a fate-mapping approach in which many or most cells arising in the ventral telencephalon will be labeled with stable expression of beta-galactosidase, GFP or alkaline phosphatase...
  53. The role of Sp8 in olfactory system development
    Ilya Vilinsky; Fiscal Year: 2006
    ..It is also expressed in specific domains of the medial telencephalon at various points during embryonic development...
  54. NF-kappaB signaling in mammalian forebrain progenitors
    Nicholas Gaiano; Fiscal Year: 2007
    ..The work proposed here investigates this question in the telencephalon, the embryonic structure that gives rise to the cerebral cortex and other areas of higher brain function...
  55. Genetic Interactions at the Cortical Striatal Border
    Laura A Cocas; Fiscal Year: 2010
    ..to patterning of ceils at the cortical-striatal border (CSB), a transient boundary in the developing telencephalon. The CSB is a source of cells that migrate to the basal telencephalic limbic system along the lateral cortical ..
  56. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
    ..abstract_text> ..
  57. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2002
    ....
  58. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
    ..This application is a competitive renewal for two NIMH grants: MH49428 and MH51561; the proposed projects herein are a synthesis of the scientific goals of MH49428 and MH51561. ..
  59. Comparative mapping of auditory telencephalon
    THOMAS TERLEPH; Fiscal Year: 2006
    ..Results will provide a detailed characterization of species-specific response properties across regions, and will help to elucidate how response preferences arise in NCM. [unreadable] [unreadable] [unreadable]..
  60. Neuropathology and Pathogenesis of Huntington's Disease
    Anton Reiner; Fiscal Year: 2008
    ..abstract_text> ..
  61. DEVELOPMENT OF THE GUSTATORY SYSTEM
    RICHARD NORTHCUTT; Fiscal Year: 2005
    ..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
  62. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  63. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  64. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..that Hedgehog-signaling between embryonic day 9 and 10 is fundamental for patterning of the mouse ventral telencephalon, from where all cortical interneurons arise...