telencephalon

Summary

Summary: Paired anteriolateral evaginations of the prosencephalon plus the lamina terminalis. The cerebral hemispheres are derived from it. Many authors consider cerebrum a synonymous term to telencephalon, though a minority include diencephalon as part of the cerebrum (Anthoney, 1994).

Top Publications

  1. pmc Revised nomenclature for avian telencephalon and some related brainstem nuclei
    Anton Reiner
    Department of Anatomy, University of Tennessee Health Science Center, Memphis 38163, USA
    J Comp Neurol 473:377-414. 2004
  2. pmc Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins
    Frederick G Strathmann
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York 14642, USA
    BMC Dev Biol 7:33. 2007
  3. ncbi Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon
    Teresa Giraldez
    Unidad de Farmacologia, Universidad de La Laguna, La Laguna, Tenerife, Spain
    J Neurochem 102:1304-15. 2007
  4. ncbi Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
  5. ncbi The origin and specification of cortical interneurons
    Carl P Wonders
    Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York 10021, USA
    Nat Rev Neurosci 7:687-96. 2006
  6. doi MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors
    Mikihito Shibata
    Laboratories for Vertebrate Body Plan and Animal Resources and Genetic Engineering, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0047, Japan
    J Neurosci 31:3407-22. 2011
  7. pmc Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis
    Wulf Haubensak
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 101:3196-201. 2004
  8. ncbi Doublecortin expression in the adult rat telencephalon
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 14:629-44. 2001
  9. ncbi Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon
    Martin März
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
    Glia 58:870-88. 2010
  10. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992

Detail Information

Publications259 found, 100 shown here

  1. pmc Revised nomenclature for avian telencephalon and some related brainstem nuclei
    Anton Reiner
    Department of Anatomy, University of Tennessee Health Science Center, Memphis 38163, USA
    J Comp Neurol 473:377-414. 2004
    ..In particular, the outdated terminology implies that most of the avian telencephalon is a hypertrophied basal ganglia, when it is now clear that most of the avian telencephalon is neurochemically,..
  2. pmc Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins
    Frederick G Strathmann
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York 14642, USA
    BMC Dev Biol 7:33. 2007
    Considerably less attention has been given to understanding the cellular components of gliogenesis in the telencephalon when compared to neuronogenesis, despite the necessity of normal glial cell formation for neurological function...
  3. ncbi Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon
    Teresa Giraldez
    Unidad de Farmacologia, Universidad de La Laguna, La Laguna, Tenerife, Spain
    J Neurochem 102:1304-15. 2007
    ..the expression pattern of both the known (delta1) and the new (delta2) isoforms in the human and monkey telencephalon. ENaC delta2 is produced by a combination of alternative transcription start sites, a frame shift in exon 3 ..
  4. ncbi Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
    ..The expression of these molecules is also affected in the entorhinal, the visual and the somatosensory cortices...
  5. ncbi The origin and specification of cortical interneurons
    Carl P Wonders
    Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York 10021, USA
    Nat Rev Neurosci 7:687-96. 2006
    ..Here, we discuss recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons...
  6. doi MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors
    Mikihito Shibata
    Laboratories for Vertebrate Body Plan and Animal Resources and Genetic Engineering, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0047, Japan
    J Neurosci 31:3407-22. 2011
    ..that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors...
  7. pmc Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis
    Wulf Haubensak
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 101:3196-201. 2004
    ..Basal progenitors are most frequent in the telencephalon, where they outnumber the apically dividing neuron-generating NE cells...
  8. ncbi Doublecortin expression in the adult rat telencephalon
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 14:629-44. 2001
    ..Given these results, we hypothesize that DCX expression in differentiated neurons could be related to its capacity for microtubule reorganization and that this fact could be linked to axonal outgrowth or synaptogenesis...
  9. ncbi Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon
    Martin März
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
    Glia 58:870-88. 2010
    ..In the telencephalon, this complexity is enhanced by an organization of the ventricular zone (VZ) in fast and slow-dividing domains,..
  10. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992
    ..Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation...
  11. doi Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate
    Ina Rothenaigner
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, Institute of Neurobiology Alfred Fessard, Avenue de la Terrasse, Gif sur Yvette Cedex, France
    Development 138:1459-69. 2011
    ..These results characterize fundamental aspects of adult progenitor cells and neurogenesis, and open the way to using virus-based technologies for stable genetic manipulations and clonal analyses in the zebrafish adult brain...
  12. ncbi Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
    Mattias Backman
    Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, University of Oslo, The National Hospital, 0027 Oslo, Norway
    Dev Biol 279:155-68. 2005
    ..In this study, we used conditional Cre/loxP system in mouse to ablate or activate beta-catenin in the telencephalon in two time windows: before and after the onset of neurogenesis...
  13. doi Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Glia 58:1345-63. 2010
    ..To understand the components of the progenitor zones in the adult zebrafish telencephalon and the link between glial characteristics and progenitor state, we examined whether canonical glial markers ..
  14. ncbi Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Dev Biol 208:166-88. 1999
    ..These results support a model in which separate, lineage-related EGF- and FGF-responsive neural stem cells are present in the embryonic telencephalic germinal zone...
  15. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum)...
  16. pmc Mechanisms of inhibition within the telencephalon: "where the wild things are"
    Gord Fishell
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    Annu Rev Neurosci 34:535-67. 2011
    ..of the diversity and mechanisms by which GABAergic interneuron populations function in different parts of the telencephalon. This is followed by a summary of the mechanisms of inhibition in the CNS...
  17. doi Migration of neuronal precursors from the telencephalic ventricular zone into the olfactory bulb in adult zebrafish
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Comp Neurol 519:3549-65. 2011
    ..Taken together, our results suggest that the RMS in the adult zebrafish telencephalon is a functional migratory pathway...
  18. ncbi Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon
    Birgit Adolf
    Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    Dev Biol 295:278-93. 2006
    ..Using BrdU tracing and immunodetection of cell-type-specific markers, we demonstrate that the adult zebrafish telencephalon contains self-renewing progenitors, which show features of adult mammalian neural stem cells but distribute ..
  19. ncbi Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
    Null mutation of the Foxg1 gene causes hypoplasia of the mouse telencephalon and loss of ventral telencephalic structures. We show that a crucial early requirement for Foxg1 is in the induction of ventral cell fate in the telencephalon...
  20. ncbi Gli3 is required for Emx gene expression during dorsal telencephalon development
    T Theil
    Institute for Molecular Biology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany thomas
    Development 126:3561-71. 1999
    ..To date, only Emx genes were known to be required for dorsal telencephalon development...
  21. ncbi A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei
    Fernando García-Moreno
    Instituto Cajal Consejo Superior de Investigaciones Cientificas, Laboratory of Telencephalic Development, Molecular, Cellular and Developmental Neurobiology Department, Madrid, Spain
    Nat Neurosci 13:680-9. 2010
    ..The diencephalic transcription factor OTP was necessary for this migratory behavior...
  22. ncbi Convergence of olfactory and vomeronasal projections in the rat basal telencephalon
    Palma Pro-Sistiaga
    Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, 02006 Albacete, Spain
    J Comp Neurol 504:346-62. 2007
    ..projections have been traditionally viewed as terminating in contiguous non-overlapping areas of the basal telencephalon. Original reports, however, described areas such as the anterior medial amygdala where both chemosensory ..
  23. ncbi The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Biol Chem 281:13374-81. 2006
    ..2nd intronic enhancer, the SRR2 shows strong regional specificity functioning only in restricted areas of the telencephalon but not in any other portions of the central nervous system such as the spinal cord...
  24. ncbi Prokineticin 2 expression is associated with neural repair of injured adult zebrafish telencephalon
    Besma Ayari
    Centre de Recherche de l Institut du Cerveau et de la Moelle épinière CRICM, 75651 Paris Cedex, France
    J Neurotrauma 27:959-72. 2010
    ..to analyze the distribution of PROK2 transcripts in the adult zebrafish brain and during injury-induced telencephalon (TC) regeneration...
  25. pmc Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon
    Tomasz Jan Nowakowski
    Developmental Biology Laboratory, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e23013. 2011
    ..for the generation of mature micro RNAs, by conditionally mutating the Dicer1 gene in the early embryonic telencephalon and analyse the molecular specification of radial glia as well as their progeny, namely postmitotic neurons ..
  26. doi Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine
    Cameron S McPherson
    Howard Florey Institute, University of Melbourne, Parkville, 3010 Victoria, Australia
    Cereb Cortex 20:941-52. 2010
    ..We conclude that there is a specific role for CREB1 in telencephalic glutamatergic neurons regulating the motivational properties of cocaine...
  27. doi Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Development 135:2531-41. 2008
    ....
  28. ncbi Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice
    Takuji Iwasato
    PRESTO, Japan Science and Technology Agency, Saitama, Japan
    Genesis 38:130-8. 2004
    ..we report the isolation of a DNA fragment containing the Emx1 gene promoter, which is responsible for dorsal telencephalon-specific expression...
  29. pmc Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon
    Jan Mulder
    European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen, UK
    Eur J Neurosci 31:2166-77. 2010
    ..that scgn may be expressed by particular neuronal contingents during prenatal development of the mammalian telencephalon. We find that scgn is expressed in neurons transiting in the subpallial differentiation zone by embryonic day (..
  30. pmc Regulation of mouse embryonic stem cell neural differentiation by retinoic acid
    Mijeong Kim
    Department of Cell Biology and Physiology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 328:456-71. 2009
    ..Transcriptional profiling indicates a substantial representation of transit amplifying neuroblasts in SFD cultures not exposed to RA...
  31. pmc Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon
    Janet E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 19:i144-51. 2009
    ..along the lateral thalamic surface, and as they approach hypothalamus make a lateral turn into ventral telencephalon. In vitro studies show that hypothalamus releases a chemorepellent for TCAs, and analyses of knockout mice ..
  32. ncbi Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)
    S Tole
    Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637, USA
    Dev Biol 217:254-65. 2000
    Little is known about the mechanisms that control the development of regional identity in the mammalian telencephalon. The Gli family of transcription factor genes is involved in the regulation of pattern at many sites in the embryo and ..
  33. ncbi Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells
    Prisca Chapouton
    Zebrafish Neurogenetics Department, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Neurosci 30:7961-74. 2010
    ..We use here the germinal zone of the zebrafish adult telencephalon to examine how the frequency of NSC divisions is regulated...
  34. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  35. ncbi Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon
    Kyuson Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, Box 0984, 94143 0984, USA
    Development 129:5029-40. 2002
    ..We suggest that alternate cell fate choices in the developing telencephalon are controlled by coordinated functions of bHLH and homeobox transcription factors through their differential ..
  36. pmc Laminar and columnar auditory cortex in avian brain
    Yuan Wang
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92093 0608, USA
    Proc Natl Acad Sci U S A 107:12676-81. 2010
    ..methods, we demonstrate the existence of comparable columnar functional modules in laminated auditory telencephalon of an avian species (Gallus gallus)...
  37. pmc Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior
    Giuliana Caronia
    Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 30:6291-301. 2010
    ..mice that were deficient in Bmpr1b constitutively, and deficient in Bmpr1a conditionally in the dorsal telencephalon. In double mutant male and female mice, the dentate gyrus (DG) was dramatically smaller than in control mice, ..
  38. ncbi Directed differentiation of telencephalic precursors from embryonic stem cells
    Kiichi Watanabe
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Nat Neurosci 8:288-96. 2005
    ..Thus, in the absence of caudalizing signals, floating aggregates of ES cells generate naive telencephalic precursors that acquire subregional identities by responding to extracellular patterning signals...
  39. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
    ..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer...
  40. ncbi Connections of the lateral and medial divisions of the goldfish telencephalic pallium
    R Glenn Northcutt
    Neurobiology Unit, Scripps Institution of Oceanography, and Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California 92093 0201, USA
    J Comp Neurol 494:903-43. 2006
    ..The topography and connections of Dl are remarkably similar to those of the hippocampus of tetrapods, whereas the topography and connections of Dm are similar to those of the amygdala...
  41. pmc Neuronal regeneration in a zebrafish model of adult brain injury
    Norihito Kishimoto
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Dis Model Mech 5:200-9. 2012
    ..Recent studies show that neurogenesis in the ventricular zone (VZ) of the adult zebrafish telencephalon has features in common with neurogenesis in the adult mammalian SVZ...
  42. ncbi Phenotypic expression of monoamines and GABA in the early development of human telencephalon, transient or not transient
    Catherine Verney
    Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, 75019, Paris, France
    J Chem Neuroanat 26:283-92. 2003
    ..such as tyrosine-hydroxylase (TH) immunoreactivity in various neuronal populations of the developing human telencephalon. The specific transporter for serotonin, serotonin transporter (SERT) has been detected in fibers of the ..
  43. pmc The development and general morphology of the telencephalon of actinopterygian fishes: synopsis, documentation and commentary
    Rudolf Nieuwenhuys
    The Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Brain Struct Funct 215:141-57. 2011
    ..The telencephalon of actinopterygian fishes differs from that in all other vertebrates in that it consists of a pair of solid ..
  44. ncbi Expression of the transcription factor Olig2 in proliferating cells in the adult zebrafish telencephalon
    Martin März
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Dev Dyn 239:3336-49. 2010
    The telencephalon of the adult zebrafish is highly proliferative: Dividing cells are found along the entire ventricular zone and in the parenchyma...
  45. pmc A genomic atlas of mouse hypothalamic development
    Tomomi Shimogori
    RIKEN BSI, 2 1 Hirosawa, Wako Shi, Saitama, Japan
    Nat Neurosci 13:767-75. 2010
    ..Our results serve as a resource for functional investigations of hypothalamic development, connectivity, physiology and dysfunction...
  46. ncbi Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes
    S A Anderson
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
    Science 278:474-6. 1997
    ..zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical ..
  47. doi Regenerative response following stab injury in the adult zebrafish telencephalon
    Martin März
    Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Dev Dyn 240:2221-31. 2011
    ..We analyzed the proliferation of glial cells and microglia in response to stab injury in the adult zebrafish telencephalon: Radial glial markers were up-regulated at the ventricle and co-expressed the proliferation nuclear antigen (..
  48. pmc Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon
    Vanessa Gil
    Molecular and Cellular Neurobiotechnology laboratory, Institute for Bioengineering of Catalonia IBEC, Barcelona E 08028, Spain
    Cereb Cortex 20:1769-79. 2010
    ..Our data support the idea that early expressed MAIPs play an active role during development and point to OMgp participating in thalamo-cortical connections...
  49. doi SOX2 expression levels distinguish between neural progenitor populations of the developing dorsal telencephalon
    Scott R Hutton
    Department of Genetics, University of North Carolina, 115 Mason Farm Rd, CB 7250, Chapel Hill, NC 27599, USA
    Dev Biol 352:40-7. 2011
    ..In the developing dorsal telencephalon, two distinct populations of neural progenitors, radial glia and intermediate progenitor cells, are ..
  50. ncbi Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
    Cortical GABAergic neurons originate in the ventral telencephalon, invade the cortex via tangential migration, and integrate into the cortical plate by surface-directed and ventricle-directed migration...
  51. ncbi Induction and patterning of the telencephalon in Xenopus laevis
    Giuseppe Lupo
    Dipartimento di Fisiologia e Biochimica, Laboratorio di Biologia Cellulare e dello Sviluppo, Universita di Pisa, via G Carducci 13, 56010 Ghezzano Pisa, Italy
    Development 129:5421-36. 2002
    ..Therefore, integration of organizer secreted molecules and of FGF, may account for patterning of the more rostral part of Xenopus CNS...
  52. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..We sketch a simplified model, in which the secondary prosencephalon (telencephalon plus hypothalamus) is a complex protosegment not subdivided into prosomeres, which exhibits patterning ..
  53. pmc Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 45:208-17. 2007
    ..thereafter the chorion, in addition to the visceral endoderm and primitive streak at gastrula stages, and the telencephalon at later stages...
  54. doi Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells
    Hiromi Takanaga
    Center for Developmental Biology, RIKEN, Kobe, Japan
    Stem Cells 27:165-74. 2009
    ..Thus these data reveal a novel transcriptional cascade, involving Gli2 --> Sox2 --> Hes5, which maintains the undifferentiated state of telencephalic NE cells...
  55. ncbi Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis
    Emily Violette Baumgart
    Institute for Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Glia 60:343-57. 2012
    ..astrocytes, we examined the glial response to an invasive stab wound injury model in the adult zebrafish telencephalon. Strikingly, already a few days after injury the wound was closed without any scar tissue...
  56. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ..In the telencephalon, the Ngns and Mash1 are expressed at high levels in complementary dorsal and ventral domains, respectively...
  57. ncbi Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon
    E M Powell
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuron 30:79-89. 2001
    Cortical interneurons arise from the proliferative zone of the ventral telencephalon, the ganglionic eminence, and migrate into the developing neocortex...
  58. pmc Seasonal neuroplasticity in the songbird telencephalon: a role for melatonin
    G E Bentley
    Department of Psychology, Behavioral Neuroendocrinology Group, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 96:4674-9. 1999
    ..This effect was observed regardless of reproductive state. To our knowledge, this is the first direct evidence of a role for melatonin in functional plasticity within the central nervous system of vertebrates...
  59. pmc FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation
    Martin Roth
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Development 137:1553-62. 2010
    ..transcriptional repressor that plays a key role in the specification, proliferation and differentiation of the telencephalon, and is expressed from the earliest stages of telencephalic development through to the adult...
  60. ncbi Effects of songs and calls on ZENK expression in the auditory telencephalon of field- and isolate-reared black capped chickadees
    Leslie S Phillmore
    Department of Psychology, Queen s University, Kingston ON, Canada K7L 3N6
    Behav Brain Res 147:125-34. 2003
    ..These findings indicated that the type of conspecific vocalization, as well as the sex of the listener, appear to modulate IEG expression in the songbird ascending auditory pathway...
  61. ncbi Expression of the genes Emx1, Tbr1, and Eomes (Tbr2) in the telencephalon of Xenopus laevis confirms the existence of a ventral pallial division in all tetrapods
    Aurora Brox
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 474:562-77. 2004
    ..xTbr1) gene and analyzed its expression compared with that of the genes xEomes (Tbr2) and xEmx1 in the telencephalon of the frog Xenopus laevis during embryonic and larval development...
  62. ncbi Zinc-containing neurons are distinct from GABAergic neurons in the telencephalon of the rat
    L Slomianka
    Department of Anatomy and Human Biology, The University of Western Australia, Nedlands
    Anat Embryol (Berl) 195:165-74. 1997
    ..Other strongly calbindin-immunoreactive neurons of the telencephalon were never double-labeled...
  63. pmc Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus
    Tianyu Zhao
    Department of Genes and Behavior, Brain Development Group, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Eur J Neurosci 28:1941-55. 2008
    ..The expanded neuroepithelium generates abundant neurons for the medial hypothalamus at the tuberal level. Finally, we have uncovered novel diencephalon-to-telencephalon migrations into septum, piriform cortex and amygdala.
  64. ncbi Emx1 and Emx2 functions in development of dorsal telencephalon
    M Yoshida
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
    Development 124:101-11. 1997
    ..In the more lateral region of telencephalon, Emx2-deficiency may be compensated for by Emx1 and vice versa...
  65. ncbi Aggression and vasotocin are associated with dominant-subordinate relationships in zebrafish
    Earl T Larson
    Department of Psychology, Northeastern University, Boston, MA 02115, USA
    Behav Brain Res 167:94-102. 2006
    ..These results suggest that the vasotocinergic system may play a role in shaping dominant-subordinate relationships and agonistic behavior in this model organism...
  66. ncbi Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    Joan Seoane
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 1300 York Avenue, New York, NY 1002, USA
    Cell 117:211-23. 2004
    ..We suggest that the activity of this network confers resistance to TGF-beta-mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells...
  67. ncbi Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Sweden
    Mech Dev 94:183-7. 2000
    ..Curr. Opin. Genet. Dev. 8, 423-429). We have studied the expression of these genes in the mouse telencephalon and found that Meis1 and Meis2 display region-specific patterns of expression from embryonic day (E)10...
  68. doi Transformation of odor representations in target areas of the olfactory bulb
    Emre Yaksi
    Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 12:474-82. 2009
    ..This mechanism can extract information about combinations of molecular features from ensembles of active and inactive mitral cells, suggesting that pattern processing in Dp establishes representations of odor objects...
  69. ncbi Connections of the ventral telencephalon (subpallium) in the zebrafish (Danio rerio)
    Elke Rink
    Brain Research Institute, University of Bremen, 28334, Bremen, Germany
    Brain Res 1011:206-20. 2004
    Connections of the medial precommissural subpallial ventral telencephalon, i.e...
  70. doi Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1
    Catherine Danesin
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, UK
    Dev Cell 16:576-87. 2009
    ..Concomitantly to these roles, Foxg1 controls the formation of the compartment boundary between telencephalon and basal diencephalon...
  71. pmc Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon
    Ashton W Powell
    Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Biol 6:e116. 2008
    ..topography of thalamocortical (TC) axon projections is initiated before they reach the cortex, in the ventral telencephalon (VTel)...
  72. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
    ..evidence that the Notch-Delta pathway plays an important role in this selection in the developing mouse telencephalon. We found that the expression patterns of the Notch ligand delta-like 1 (Dll1) and of the active form of ..
  73. pmc Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon
    Alexandra A Gulacsi
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, New York, 10065, USA
    Nat Neurosci 11:1383-91. 2008
    Development of the telencephalon involves the coordinated growth of diversely patterned brain structures...
  74. ncbi LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem
    S Bulchand
    Department of Biological Sciences, Tata Institute of Fundamental Research, 400005, Mumbai, India
    Mech Dev 100:165-75. 2001
    We are interested in the early mechanisms that initiate regional patterning in the dorsal telencephalon, which gives rise to cerebral cortex...
  75. ncbi Fibroblast growth factor 8 regulates neocortical guidance of area-specific thalamic innervation
    Tomomi Shimogori
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:6550-60. 2005
    ..Our findings demonstrate that thalamocortical axons are directed by sequential, positional cues within the cortex and implicate FGF8 as an indirect regulator of thalamocortical innervation...
  76. ncbi Anatomical distribution and cellular basis for high levels of aromatase activity in the brain of teleost fish: aromatase enzyme and mRNA expression identify glia as source
    P M Forlano
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 21:8943-55. 2001
    ..activity in a vocal fish, the plainfin midshipman (Porichthys notatus), and found highest levels in the telencephalon and lower levels in the sonic hindbrain, which was dimorphic between and within (males) sexes...
  77. ncbi The cellular fate of cortical progenitors is not maintained in neurosphere cultures
    Ondrej Machon
    Institute of Molecular Genetics, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic
    Mol Cell Neurosci 30:388-97. 2005
    ..We isolated neural progenitors from the dorsal telencephalon of D6-GFP mice and cultured them in vitro...
  78. ncbi Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon
    J R Menezes
    Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322
    J Neurosci 14:5399-416. 1994
    ..and morphology of immature neurons in the proliferative ventricular and subventricular zones of the developing telencephalon. Mouse brains from embryonic day 12 (E12) to postnatal day 5 (P5) were fixed either with a non-cross-linking ..
  79. ncbi Genetic patterning of the mammalian telencephalon by morphogenetic molecules and transcription factors
    Hiroshi Takahashi
    Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan
    Birth Defects Res C Embryo Today 78:256-66. 2006
    ..studies indicate that they are involved in regional specification of the dorsal, ventral, and lateral telencephalon. For patterning of the dorsal telencephalon, FGF8 controls the anteroposterior patterning, while BMP and Wnt ..
  80. doi Physiological and health consequences of social status in zebrafish (Danio rerio)
    Amy L Filby
    School of Biosciences, University of Exeter, Hatherly Laboratories, Prince of Wales Road, Exeter, Devon EX4 4PS, United Kingdom
    Physiol Behav 101:576-87. 2010
    ..The wide-ranging physiological differences seen between dominant and subordinate zebrafish as a consequence of their social status suggest negative health impacts for subordinates after prolonged durations in those hierarchies...
  81. pmc AhR-mediated gene expression in the developing mouse telencephalon
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
    Reprod Toxicol 28:321-8. 2009
    ..is modulated through an AhR-dependent interaction with key regulatory neuronal differentiation pathways during telencephalon development...
  82. pmc Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis
    Joseph A Nielsen
    Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    BMC Neurosci 10:98. 2009
    ....
  83. pmc Perlecan controls neurogenesis in the developing telencephalon
    Amparo Girós
    Department of Biochemistry and Molecular Biology, Universitat de Valencia, Burjassot, Spain
    BMC Dev Biol 7:29. 2007
    ..Microcephaly consists of thinner cerebral walls and underdeveloped ganglionic eminences. We have studied the mechanisms that generate brain atrophy in telencephalic areas where basal lamina is intact...
  84. doi Acute in utero morphine exposure slows G2/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse
    Tim J Sargeant
    School of Biological Sciences, Wellington 6140, New Zealand
    Eur J Neurosci 28:1060-7. 2008
    ..5 mouse increases the length of the G(2)/M phase of the radial glial cell cycle in the dorsal telencephalon, as well as slows interkinetic nuclear migration of radial glial nuclei from the basal ventricular zone to the ..
  85. ncbi Seasonal variation in androgen-metabolizing enzymes in the diencephalon and telencephalon of the male European starling (Sturnus vulgaris)
    L V Riters
    Department of Psychology, Behavioral Neuroendocrinology Group, Johns Hopkins University, Baltimore, MD, USA
    J Neuroendocrinol 13:985-97. 2001
    ..is critical for mate attraction during the breeding season and is regulated by steroid-sensitive nuclei in the telencephalon and diencephalon...
  86. ncbi Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice
    A Reiner
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee, The Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 21:7608-19. 2001
    ..The Hdh (-/-) cells were, however, 5-10 times more common in hypothalamus, midbrain, and hindbrain than in telencephalon and thalamus...
  87. ncbi An experimental study of the connections of the telencephalon in the rainbow trout (Oncorhynchus mykiss). I: Olfactory bulb and ventral area
    Mónica Folgueira
    Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruna, 15071 A Coruna, Spain
    J Comp Neurol 480:180-203. 2004
    ..The olfactory bulbs maintain reciprocal connections with several regions of the telencephalon [ventral nucleus of V (Vv), supracommissural nucleus (Vs), posterior zone of D (Dp), preoptic nucleus], and ..
  88. doi Evidences for tangential migrations in Xenopus telencephalon: developmental patterns and cell tracking experiments
    Nerea Moreno
    Department of Cell Biology, Faculty of Biology, University Complutense of Madrid, Spain
    Dev Neurobiol 68:504-20. 2008
    ..Our findings strongly suggest that the developing Xenopus telencephalon shares many similarities with amniotes in terms of neuronal specification and migrations...
  89. pmc Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1
    Antigoni Ekonomou
    Mammalian Neurogenesis Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kingdom
    PLoS Biol 3:e186. 2005
    ..Several transcription factors that are expressed mainly in precursors of the ventral telencephalon have been shown to control neuronal specification, but it has been unclear whether subtype identity is also ..
  90. ncbi Glutamate and regulation of proliferation in the developing mammalian telencephalon
    Kelvin C Luk
    Cone Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada
    Dev Neurosci 26:218-28. 2004
    ..Cells in neither dorsal nor ventral telencephalon-derived neurospheres showed altered proliferation following exposure to either class of ionotropic glutamate ..
  91. ncbi Spatial learning deficits after the development of dorsomedial telencephalon lesions in goldfish
    Kotaro Saito
    Department of Psychology, Keio University, Mita 2 15 45, Minato ku, Tokyo 108 8345, Japan
    Neuroreport 15:2695-9. 2004
    The effects of lesions in the dorsal area of the caudal telencephalon (Carassius auratus) on the retention of spatial learning in goldfish were examined...
  92. ncbi Gene regulation by song in the auditory telencephalon of songbirds
    Claudio V Mello
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci 9:63-73. 2004
    ..regulator linked to synaptic plasticity, is rapidly and transiently induced in several discrete areas of the telencephalon. This phenomenon is most marked in the caudomedial neostriatum (NCM), a major auditory processing area...
  93. ncbi Microglia in the cerebral wall of the human telencephalon at second trimester
    Payam Rezaie
    Department of Biological Sciences, Faculty of Science, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Cereb Cortex 15:938-49. 2005
    ..investigated the distribution, morphology and phenotype of microglia specifically within the wall of the human telencephalon from 12 to 24 gestational weeks (gw), a period that corresponds to the development of thalamocortical fibres ..
  94. doi The forebrain of actinopterygians revisited
    Rudolf Nieuwenhuys
    The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Brain Behav Evol 73:229-52. 2009
    ..Further, it is proposed that the lateral olfactory tract in teleosts, which supplies most of the olfactory fibers to Dp, is not homologous to the same-named tract in the inverted forebrains of most other vertebrates...
  95. ncbi Non-oscillatory discharges of an F-prostaglandin responsive neuron population in the olfactory bulb-telencephalon transition area in lake whitefish
    F Laberge
    Department of Zoology, University of Manitoba, Manitoba, Winnipeg, Canada R3T 2N2
    Neuroscience 116:1089-95. 2003
    ..responsive to F-prostaglandins in the ventromedial brain tissue strip connecting the olfactory bulb to the telencephalon. Of the 64 neurons examined in this area, 33% showed excitatory and 11% inhibitory responses to F-..
  96. pmc CB(1) cannabinoid receptor activation dose dependently modulates neuronal activity within caudal but not rostral song control regions of adult zebra finch telencephalon
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Psychopharmacology (Berl) 199:265-73. 2008
    CB(1) cannabinoid receptors are distinctly expressed at high density within several regions of zebra finch telencephalon, including those known to be involved in song learning (lMAN and Area X) and production (HVC and RA) because (1) ..
  97. ncbi Stalking the everted telencephalon: comparisons of forebrain organization in basal ray-finned fishes and teleosts
    Mark R Braford
    Neuroscience Department, Oberlin College, Oberlin, Ohio 44074, USA
    Brain Behav Evol 74:56-76. 2009
    ..These hypotheses are evaluated and some persisting problems are enumerated...
  98. doi The integration of song environment by catecholaminergic systems innervating the auditory telencephalon of adult female European starlings
    Keith W Sockman
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Dev Neurobiol 68:656-68. 2008
    ..that primarily sing long songs over those that primarily sing short songs, and sensitivity of the auditory telencephalon to song length depends on the prevalence of long songs in the environment...
  99. pmc Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon
    Emmanuelle Huillard
    INSERM, U873, CEA, iRTSV LTS, 17 Av des Martyrs, F 38054 Grenoble, France
    Mol Cell Biol 30:2737-49. 2010
    ..Thus, CK2beta appears to play an essential and uncompensated role in central nervous system development...
  100. doi Developmental origins of species differences in telencephalon and tectum size: morphometric comparisons between a parakeet (Melopsittacus undulatus) and a quail (Colinus virgianus)
    Georg F Striedter
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Comp Neurol 507:1663-75. 2008
    ..larger brains than other birds, relative to their body size, and they possess a proportionately larger telencephalon. For example, the telencephalon occupies approximately 68% of the brain in parakeets but only 52% in bobwhite ..
  101. ncbi The teleostean forebrain: a comparative and developmental view based on early proliferation, Pax6 activity and catecholaminergic organization
    Mario F Wullimann
    Brain Research Institute, University of Bremen, Bremen, Germany
    Brain Res Bull 57:363-70. 2002
    ..Further, early Pax6 protein distribution in the zebrafish telencephalon corresponds to the migrating stream noted at the pallial-subpallial boundary in amniotes, but a ventricular, ..

Research Grants83

  1. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina Zhdanova; Fiscal Year: 2009
    ..to cocaine during the major periods of cortical (pallium) and limbic system (dorsomedial and dorsolateral telencephalon) development, synchronized with either the nighttime or daytime circadian phase...
  2. Genetic Control of Basal Telencephalic Development
    John Rubenstein; Fiscal Year: 2009
    ..The embryonic basal telencephalon generates subcortical nuclei and cortical interneurons that are required for the function of these circuits...
  3. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy B Macklin; Fiscal Year: 2010
    ..for migration of neurons and oligodendrocyte progenitor cells in cerebellum, optic nerve and embryonic telencephalon, using real time imaging...
  4. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2010
    ..These GnRH neurons originate outside the CNS and migrate into the ventral telencephalon and hypothalamus during embryogenesis...
  5. The Morphogen and Selector Gene Network in the Dorsal Telencephalic Midline
    Edwin S Monuki; Fiscal Year: 2010
    ..this project is to better understand the network that governs development of the dorsal midline region in the telencephalon. The proposal is based on a signaling network model we developed that can explain holoprosencephaly, the most ..
  6. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  7. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
    ..Results suggested that BF-1 was essential for growth of the telencephalon because at early stages, no significant differences in size of the telencephalic vesicles were apparent...
  8. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2000
    ..Results suggested that BF-1 was essential for growth of the telencephalon because at early stages, no significant differences in size of the telencephalic vesicles were apparent...
  9. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 1999
    ..Results suggested that BF-1 was essential for growth of the telencephalon because at early stages, no significant differences in size of the telencephalic vesicles were apparent...
  10. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  11. Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
    Kenneth Campbell; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The mammalian telencephalon represents the region of the brain that displays the most cellular diversity, particularly with respect to neuronal subtypes...
  12. Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The mammalian telencephalon represents the region of the brain that displays the most cellular diversity, particularly with respect to neuronal subtypes...
  13. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2002
    The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  14. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  15. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2003
    The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  16. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2004
    The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  17. Roles of Gsh1 & 2 genes in telencephalic neurogenesis
    Kenneth Campbell; Fiscal Year: 2005
    The telencephalon represents the region of the brain most concerned with cognition and voluntary movement...
  18. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2010
    ..to cocaine during the major periods of cortical (pallium) and limbic system (dorsomedial and dorsolateral telencephalon) development, synchronized with either the nighttime or daytime circadian phase...
  19. LEWIS X OLIGOSACCHARIDE IN THE EMBRVONIC CNS
    Paul Patterson; Fiscal Year: 1999
    ..It's pattern of labeling delineates a novel set of boundaries in the rodent telencephalon and diencephalon, displaying a partial overlap with the expression of the transcription factor BF- 1...
  20. NEURAL MECHANISMS OF ANOREXIA
    ALAN WATTS; Fiscal Year: 2009
    ..In particular, studies will focus on interactions between the telencephalon, and the hypothalamus and hindbrain, since the telencephalon likely plays a critical role in clinically-..
  21. NEURAL MECHANISMS OF ANOREXIA
    Alan G Watts; Fiscal Year: 2010
    ..In particular, studies will focus on interactions between the telencephalon, and the hypothalamus and hindbrain, since the telencephalon likely plays a critical role in clinically-..
  22. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2002
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  23. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2004
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  24. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  25. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2001
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  26. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2003
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  27. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2001
    ..The factors being tested are expressed in the developing mesencephalon, diencephalon and telencephalon and are involved in GABAergic development...
  28. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..and FGF2 transgenic mice with regard to volume, cell number and apoptosis within histogenic domains of the telencephalon containing neuronal and glial progenitor cells...
  29. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..and FGF2 transgenic mice with regard to volume, cell number and apoptosis within histogenic domains of the telencephalon containing neuronal and glial progenitor cells...
  30. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2001
    ..and FGF2 transgenic mice with regard to volume, cell number and apoptosis within histogenic domains of the telencephalon containing neuronal and glial progenitor cells...
  31. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2000
    ..and FGF2 transgenic mice with regard to volume, cell number and apoptosis within histogenic domains of the telencephalon containing neuronal and glial progenitor cells...
  32. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2002
    ..each of these broadly defined functions, and has shown that they-along with closely associated limbic telencephalon regions-project topographically to the lateral hypothalamic area (LHA)...
  33. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2004
    ..each of these broadly defined functions, and has shown that they-along with closely associated limbic telencephalon regions-project topographically to the lateral hypothalamic area (LHA)...
  34. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2003
    ..each of these broadly defined functions, and has shown that they-along with closely associated limbic telencephalon regions-project topographically to the lateral hypothalamic area (LHA)...
  35. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2005
    ..each of these broadly defined functions, and has shown that they-along with closely associated limbic telencephalon regions-project topographically to the lateral hypothalamic area (LHA)...
  36. The Morphogen and Selector Gene Network in the Dorsal Telencephalic Midline
    Edwin Monuki; Fiscal Year: 2009
    ..this project is to better understand the network that governs development of the dorsal midline region in the telencephalon. The proposal is based on a signaling network model we developed that can explain holoprosencephaly, the most ..
  37. EVOLUTION OF THE TELENCEPHALON
    RICHARD NORTHCUTT; Fiscal Year: 1993
    ..application, a plan is outlined for continuing studies on the organization and evolution of the vertebrate telencephalon. Living vertebrates constitute two major evolutionary radiations: jawless fishes (agnathans) and jawed ..
  38. EVOLUTION OF THE TELENCEPHALON
    RICHARD NORTHCUTT; Fiscal Year: 1990
    ..application, a plan is outlined for continuing studies on the organization and evolution of the vertebrate telencephalon. Living vertebrates constitute two major evolutionary radiations: jawless fishes (agnathans) and jawed ..
  39. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy Macklin; Fiscal Year: 2009
    ..for migration of neurons and oligodendrocyte progenitor cells in cerebellum, optic nerve and embryonic telencephalon, using real time imaging...
  40. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy Macklin; Fiscal Year: 2009
    ..for migration of neurons and oligodendrocyte progenitor cells in cerebellum, optic nerve and embryonic telencephalon, using real time imaging...
  41. NEUROGENESIS IN THE OLFACTORY AND VOMERONASAL SYSTEMS
    David Holtzman; Fiscal Year: 1993
    ..most terrestrial vertebrates, are the only sensory systems that are known to send information directly to the telencephalon, and they do so via completely separate pathways...
  42. MOLECULAR DESCRIPTION OF THE CORTEX AND HIPPOCAMPUS
    J Sutcliffe; Fiscal Year: 1990
    ..levels in diencephalon structures and are not detectable in either brain stem or cerebellum, the concept of a telencephalon-enriched battery of genes has emerged...
  43. SPINOHYPOTHALAMIC AND SPINOTELENCEPHALIC TRACTS
    GLENN GIESLER; Fiscal Year: 1990
    ..we have recently found that a large number of spinal cord neurons project directly to the hypothalamus and telencephalon in rats...
  44. TECTOPULVINAR SYSTEM: MOTION DETECTION AND EVOLUTION
    Harvey Karten; Fiscal Year: 2003
    ..suggest that the tectopulvinar system is one of the most ancient components of the ascending pathways to the telencephalon and is vital to the process of motion detection...
  45. TECTOPULVINAR SYSTEM: MOTION DETECTION AND EVOLUTION
    Harvey Karten; Fiscal Year: 2001
    ..suggest that the tectopulvinar system is one of the most ancient components of the ascending pathways to the telencephalon and is vital to the process of motion detection...
  46. TECTOPULVINAR SYSTEM: MOTION DETECTION AND EVOLUTION
    Harvey Karten; Fiscal Year: 2002
    ..suggest that the tectopulvinar system is one of the most ancient components of the ascending pathways to the telencephalon and is vital to the process of motion detection...
  47. TECTOPULVINAR SYSTEM: MOTION DETECTION AND EVOLUTION
    Harvey Karten; Fiscal Year: 2004
    ..suggest that the tectopulvinar system is one of the most ancient components of the ascending pathways to the telencephalon and is vital to the process of motion detection...
  48. DEVELOPMENT AND MIGRATION OF LHRH NEURONS
    Robert Norgren; Fiscal Year: 1999
    ..have demonstrated that X-linked Kallmann's disease is due to a failure of the olfactory nerve to enter the telencephalon and LHRH neurons to migrate into the brain...
  49. Molecular Mechanisms of Cerebral Cortical Patterning
    Elizabeth Grove; Fiscal Year: 2002
    ..that the signaling molecule FGF8 specifies positional identity in the neocortex from a source in the anterior telencephalon. Modifying the endogenous anterior FGF8 signal shifts areas along the anterior/posterior (A/P) axis of the ..
  50. Molecular Mechanisms of Cerebral Cortical Patterning
    Elizabeth Grove; Fiscal Year: 2005
    ..that the signaling molecule FGF8 specifies positional identity in the neocortex from a source in the anterior telencephalon. Modifying the endogenous anterior FGF8 signal shifts areas along the anterior/posterior (A/P) axis of the ..
  51. Molecular Mechanisms of Cerebral Cortical Patterning
    Elizabeth Grove; Fiscal Year: 2004
    ..that the signaling molecule FGF8 specifies positional identity in the neocortex from a source in the anterior telencephalon. Modifying the endogenous anterior FGF8 signal shifts areas along the anterior/posterior (A/P) axis of the ..
  52. Molecular Mechanisms of Cerebral Cortical Patterning
    Elizabeth Grove; Fiscal Year: 2003
    ..that the signaling molecule FGF8 specifies positional identity in the neocortex from a source in the anterior telencephalon. Modifying the endogenous anterior FGF8 signal shifts areas along the anterior/posterior (A/P) axis of the ..
  53. Embryonic regulation of GnRH neuron migration and function
    David Kozlowski; Fiscal Year: 2009
    ..These GnRH neurons originate outside the CNS and migrate into the ventral telencephalon and hypothalamus during embryogenesis...
  54. AUDITORY EXPERIENCE AND ADULT NEURON TURNOVER IN BIRDS
    JOHN KIRN; Fiscal Year: 2003
    ..In adult warm-blooded vertebrates, the most widespread production of neurons occurs in the avian telencephalon. In songbirds, many new neurons are inserted into the High Vocal Center (HVC), a region necessary for the ..
  55. AUDITORY EXPERIENCE AND ADULT NEURON TURNOVER IN BIRDS
    JOHN KIRN; Fiscal Year: 2002
    ..In adult warm-blooded vertebrates, the most widespread production of neurons occurs in the avian telencephalon. In songbirds, many new neurons are inserted into the High Vocal Center (HVC), a region necessary for the ..
  56. AUDITORY EXPERIENCE AND ADULT NEURON TURNOVER IN BIRDS
    JOHN KIRN; Fiscal Year: 2001
    ..In adult warm-blooded vertebrates, the most widespread production of neurons occurs in the avian telencephalon. In songbirds, many new neurons are inserted into the High Vocal Center (HVC), a region necessary for the ..
  57. Generation of Cortical Motoneurons from Embryonic Stem Cells
    Xue Jun Li; Fiscal Year: 2006
    ..be assessed by their interaction with lower motoneurons in culture and following transplantation to dorsal telencephalon of a chick embryo...
  58. Generation of Cortical Motoneurons from Embryonic Stem Cells
    Xue Jun Li; Fiscal Year: 2007
    ..be assessed by their interaction with lower motoneurons in culture and following transplantation to dorsal telencephalon of a chick embryo...
  59. Generation of Cortical Motoneurons from Embryonic Stem Cells
    Xue Jun Li; Fiscal Year: 2007
    ..be assessed by their interaction with lower motoneurons in culture and following transplantation to dorsal telencephalon of a chick embryo...
  60. Morphogenesis and function of the cerebral cortex
    Flora Vaccarino; Fiscal Year: 2006
    ..test these hypotheses, we will use mice lacking the Fgfr-1 gene product in neuroepithelial cells of the dorsal telencephalon by site-specific recombination (conditional knockout) beginning at either E9.5 or E13.5 stages of development...
  61. Morphogenesis and function of the cerebral cortex
    Flora Vaccarino; Fiscal Year: 2007
    ..test these hypotheses, we will use mice lacking the Fgfr-1 gene product in neuroepithelial cells of the dorsal telencephalon by site-specific recombination (conditional knockout) beginning at either E9.5 or E13.5 stages of development...
  62. Morphogenesis and function of the cerebral cortex
    Flora Vaccarino; Fiscal Year: 2004
    ..test these hypotheses, we will use mice lacking the Fgfr-1 gene product in neuroepithelial cells of the dorsal telencephalon by site-specific recombination (conditional knockout) beginning at either E9.5 or E13.5 stages of development...
  63. Morphogenesis and function of the cerebral cortex
    Flora Vaccarino; Fiscal Year: 2005
    ..test these hypotheses, we will use mice lacking the Fgfr-1 gene product in neuroepithelial cells of the dorsal telencephalon by site-specific recombination (conditional knockout) beginning at either E9.5 or E13.5 stages of development...
  64. NEUROTROPHIC FACTOR REGULATION IN BRAIN AGING
    Christine Gall; Fiscal Year: 1999
    ..g. forebrain cholinergic, monoaminergic) as well as decreases in excitatory synapses in cortical telencephalon. The proposed research will examine the possibility that disturpances in neurotrophic relationships contribute ..
  65. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2002
    This project addresses fundamental neuroantomical issues about parts of the telencephalon, diencephalon and brainstem that are strongly influenced by mesotelencephalic dopamine and subserve spontaneous, purposeful behaviors...
  66. LATERAL LINE PATHWAYS
    ROBERT BOORD; Fiscal Year: 1990
    ..reveal that the mesencephalic electrosensory lateral line nucleus projects to the medial pallium of the telencephalon via a posterior lateral thalamic relay center...
  67. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2005
    This project addresses fundamental neuroantomical issues about parts of the telencephalon, diencephalon and brainstem that are strongly influenced by mesotelencephalic dopamine and subserve spontaneous, purposeful behaviors...
  68. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2004
    This project addresses fundamental neuroantomical issues about parts of the telencephalon, diencephalon and brainstem that are strongly influenced by mesotelencephalic dopamine and subserve spontaneous, purposeful behaviors...
  69. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2003
    This project addresses fundamental neuroantomical issues about parts of the telencephalon, diencephalon and brainstem that are strongly influenced by mesotelencephalic dopamine and subserve spontaneous, purposeful behaviors...
  70. LATERAL LINE PATHWAYS
    ROBERT BOORD; Fiscal Year: 1991
    ..reveal that the mesencephalic electrosensory lateral line nucleus projects to the medial pallium of the telencephalon via a posterior lateral thalamic relay center...
  71. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2010
    ..The embryonic basal telencephalon generates subcortical nuclei and cortical interneurons that are required for the function of these circuits...
  72. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  73. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2003
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  74. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  75. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2004
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  76. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2006
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  77. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  78. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  79. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2007
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  80. REGENERATION OF THE OPTIC NERVE
    Frank Scalia; Fiscal Year: 1993
    ..leopard frog (Rana pibiens), optic fibers regenerating after surgical displacement of the optic nerve into the telencephalon regularly form a laminar, synaptic, terminal field in the primary olfactory cortex...