Genomes and Genes
Summary: Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
Publications243 found, 100 shown here
- Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxietyDavid L Walker
Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
Eur J Pharmacol 463:199-216. 2003....
- Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responsesD L Walker
Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30329, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:1291-308. 2009....
- Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalisAndrew S Fox
Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
J Neurosci 30:7023-7. 2010..Thus it appears that an important function of the OFC in response to threat is to modulate the BNST, which may more directly influence the expression of BI...
- Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2J Radulovic
Max Planck Institute for Experimental Medicine, Department for Molecular Neuroendocrinology, 37075 Goettingen, Germany
J Neurosci 19:5016-25. 1999..The involvement of either receptor subtype was demonstrated by region-specific injections of astressin and antisauvagine-30...
- Induction by kainate of theta frequency rhythmic activity in the rat medial septum-diagonal band complex in vitroHelen L Garner
School of Biomedical Sciences, The Worsley Building, University of Leeds, Leeds LS2 9JT, UK
J Physiol 564:83-102. 2005..We conclude that kainate activation of neuronal circuitry in the MSDB is capable of synchronization of rhythmic activity in the MSDB, and that this may underlie the mechanism for phase-locking rhythmic burst activity in the MSDB in vivo...
- Effects of bed nucleus of the stria terminalis lesions on conditioned anxiety: aversive conditioning with long-duration conditional stimuli and reinstatement of extinguished fearJaylyn Waddell
Department of Psychology, University of Vermont, Burlington, VT, USA
Behav Neurosci 120:324-36. 2006..Results are consistent with behavioral and anatomical distinctions between fear and anxiety and with a behavior-systems view of defensive conditioning...
- Three types of neurochemical projection from the bed nucleus of the stria terminalis to the ventral tegmental area in adult miceTakehiro Kudo
Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
J Neurosci 32:18035-46. 2012..VGluT2(+) and VGluT3(+) BST neurons further supply additional projections, which may principally convey excitatory or inhibitory inputs, respectively, to the VTA...
- Juxtacapsular nucleus of the stria terminalis of the adult rat: extrinsic inputs, cell types, and neuronal modules: a combined Golgi and electron microscopic studyJorge Larriva-Sahd
Instituto de Neurobiologia, Campus UNAM UAQ, Juriquilla, Queretaro, CP 76001 Qro, Mexico
J Comp Neurol 475:220-37. 2004..Additional neural interaction between Ju neurons utilizes gap junction-mediated electrotonic coupling...
- A switch in the neuromodulatory effects of dopamine in the oval bed nucleus of the stria terminalis associated with cocaine self-administration in ratsMichal Krawczyk
Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
J Neurosci 31:8928-35. 2011..This change was unique to voluntary intake of cocaine and maintained after a withdrawal period, suggesting a mechanism underlying the maintenance of cocaine self-administration and perhaps craving during drug-free periods...
- A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalisShimon Amir
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec H4B 1R6, Canada
J Neurosci 24:781-90. 2004....
- Differential projections of dorsal raphe nucleus neurons to the lateral septum and striatumMaria Waselus
Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, 900 Walnut Street, Philadelphia, PA 19107, USA
J Chem Neuroanat 31:233-42. 2006..Taken together with previous microdialysis studies, these results support the existence of distinct DRN-5-HT-forebrain projections that are differentially regulated by stress...
- Dissociation of the morphological correlates of stress-induced anxiety and fearJ M Pego
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
Eur J Neurosci 27:1503-16. 2008..In conclusion, this study shows that chronic stress impacts on BNST structure and function; its findings pertain to the modulation of emotional behaviour and the maladaptive response to stress...
- Topography of projections from amygdala to bed nuclei of the stria terminalisH W Dong
Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA
Brain Res Brain Res Rev 38:192-246. 2001..The functional significance of these projections is discussed with reference to what is known about the output of the bed nuclei...
- Basic organization of projections from the oval and fusiform nuclei of the bed nuclei of the stria terminalis in adult rat brainH W Dong
Neuroscience Program, University of Southern California, Los Angeles, California 90089-2520, USA
J Comp Neurol 436:430-55. 2001..These and other results suggest that the BSTov and BSTfu are basal telencephalic parts of a circuit that coordinates autonomic, neuroendocrine, and ingestive behavioral responses during stress...
- Persistent anxiolytic affects after chronic administration of the CRF₁ receptor antagonist R121919 in ratsDavid A Gutman
Center for Comprehensive Informatics, Emory University, 36 Eagle Row, Room 572, Suite 4000, Atlanta, GA 30322, USA
Neuropharmacology 60:1135-41. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
- Lateral septal neuronal firing rate increases during proestrus-estrus in the ratC M Contreras
Laboratorio de Neurofarmacologia, Instituto de Neuroetologia, Universidad Veracruzana, Mexico City, Mexico
Physiol Behav 68:279-84. 2000..It is concluded that the higher firing rate in neurons from the dorsal aspect of the LSN during proestrus-estrus, may be associated with an increased motivation to escape from a stressful situation...
- Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brain stemFrank Z Nagy
Center for Molecular and Behavioral Neuroscience, The State University of New Jersey, Newark, NJ 07102, USA
J Neurophysiol 100:3429-36. 2008..These results point to a hitherto unsuspected level of temporal coordination between the inputs and outputs of CE and BNST neurons, supporting the idea of shared functions...
- Noradrenaline triggers GABAA inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental areaEric C Dumont
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97239, USA
J Neurosci 24:8198-204. 2004..This mechanism might contribute to the withdrawal-induced inhibition of dopamine neurons and explain how noradrenergic drugs microinjected into the vlBNST reduce aversive aspects of opioid withdrawal...
- Chronically elevated corticosterone in the amygdala increases corticotropin releasing factor mRNA in the dorsolateral bed nucleus of stria terminalis following duressJack D Shepard
Department of Biological Sciences, Towson University, Towson, MD, USA
Behav Brain Res 174:193-6. 2006..Corticosterone also resulted in an increased number of neurons expressing CRF in the dorsolateral BNST in response to the behavioral stimuli...
- Waiting for spiders: brain activation during anticipatory anxiety in spider phobicsThomas Straube
Department of Biological and Clinical Psychology, Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University, Jena, Germany
Neuroimage 37:1427-36. 2007..Thus, activation in different ACC regions and the medial prefrontal cortex seems to be specifically associated with the severity of experienced anticipatory anxiety in subjects with spider phobia...
- The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fearSevil Duvarci
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
J Neurosci 29:10357-61. 2009..Overall, this suggests that inter-individual variations in fear generalization and anxiety phenotype are determined by BNST influences on the amygdala and/or its targets...
- Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neuronsFrançois Georges
Laboratory for Neuromodulation and Behavior, Department of Psychiatry, Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
J Neurosci 22:5173-87. 2002..These results reveal that inputs from the vBNST exert a strong excitatory influence on VTA DA neurons mediated by both NMDA and non-NMDA receptors...
- Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and functionLuis V Colom
Department of Biological Sciences at the University of Texas at Brownsville Texas Southmost College, 80 Fort Brown, Brownsville, TX 78520, USA
Neurobiol Aging 31:46-57. 2010..The Abeta induced injury of septal cholinergic and glutamatergic networks may contribute to an altered hippocampal theta rhythm which may underlie the memory loss typically observed in AD patients...
- Chronic social stress in the visible burrow system modulates stress-related gene expression in the bed nucleus of the stria terminalisDennis C Choi
Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Physiol Behav 89:301-10. 2006....
- Thyroidectomy alters the daily pattern of expression of the clock protein, PER2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in ratsShimon Amir
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, QC, Canada
Neurosci Lett 407:254-7. 2006..Thus, although thyroid hormones modulate PER2 expression in the brain, the effect is tissue specific and therefore likely not to be mediated by a direct effect of the hormone on gene expression...
- Behavioral and hormonal regulation of expression of the clock protein, PER2, in the central extended amygdalaShimon Amir
Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, QC, Canada
Prog Neuropsychopharmacol Biol Psychiatry 33:1321-8. 2009....
- Variations in daily expression of the circadian clock protein, PER2, in the rat limbic forebrain during stable entrainment to a long light cycleValerie L Harbour
Department of Psychology, Center for Studies in Behavioral Neurobiology FRSQ Groupe de Recherche en Neurobiologie Comportementale, Concordia University, 7141 Sherbrooke Street West, SP 244, Montreal, QC, H4B 1R6, Canada
J Mol Neurosci 45:154-61. 2011....
- Consistency and diversity of spike dynamics in the neurons of bed nucleus of stria terminalis of the rat: a dynamic clamp studyAttila Szucs
BioCircuits Institute, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 5:e11920. 2010..The high degree of their dynamical diversity has implications to their cooperative dynamics and synchronization...
- Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental areaAlice H Luo
Behavioral Neuroscience Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Science 333:353-7. 2011..This transsynaptic link between hippocampus and VTA appears to be an important substrate by which environmental context regulates goal-directed behavior...
- The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic-pituitary-adrenocortical axis responsiveness to acute and chronic stressDennis C Choi
Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Psychoneuroendocrinology 33:659-69. 2008..The data further suggest that acute versus chronic stress integration are subserved by different brain circuitry...
- Motivational Modulation of Rhythms of the Expression of the Clock Protein PER2 in the Limbic ForebrainShimon Amir
Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6 Canada
Biol Psychiatry 65:829-34. 2009..Thus, circadian information from the SCN and homeostatic signals are integrated in these regions of the limbic forebrain to affect the temporal organization of motivational and emotional processes...
- Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdalaH E Day
Mental Health Research Institute and Psychology Department, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 21:732-40. 2001..These data suggest that the context in which psychostimulants are given powerfully and differentially alters the response of limbic structures that have been functionally implicated in drug reinforcement and emotional behaviors...
- Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalisSayamwong E Hammack
Department of Psychiatry and Behavioral Science, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
J Neurophysiol 98:638-56. 2007..The functional relevance of each cell type is discussed in relation to prior anatomical studies, as well as how these currents may interact to modulate neuronal activity within the BNST(ALG)...
- Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart HeimerDavid L Walker
Yerkes National Primate Center and the Center for Behavioral Neuroscience, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
Brain Struct Funct 213:29-42. 2008..The generality of this idea is illustrated by selective studies looking at context conditioning, social defeat, drug withdrawal and stress induced reinstatement...
- Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activityJonathan A Oler
Departments of Psychiatry, HealthEmotions Research Institute, University of Wisconsin Madison, 53719, USA
J Neurosci 29:9961-6. 2009..Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology...
- Does the bed nucleus of the stria terminalis mediate fear behaviors?D Treit
Department of Psychology, University of Alberta, Edmonton, Canada
Behav Neurosci 112:379-86. 1998..However, BNST lesions produced none of these anti-fear effects; thus, its involvement in the behavioral expression of fear is questionable...
- Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: implications for the integration of limbic inputsDennis C Choi
Neuroscience Program and Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Neurosci 27:2025-34. 2007....
- Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalisJohn P Christianson
Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, Colorado, USA
Biol Psychiatry 70:458-64. 2011..Safety signals exert a powerful buffering effect when provided during exposure to uncontrollable stressors. We evaluated the role of the sensory insular cortex (Si) and the extend amygdala in this "safety signal effect."..
- GABAA receptor activation in the lateral septum reduces the expression of conditioned defeat and increases aggression in Syrian hamstersMark M McDonald
The Neuroscience Institute and Center for Behavioral Neuroscience, Georgia State University, 161 Jesse Hill Jr Drive, Suite 832, Atlanta, GA 30303, USA
Brain Res 1439:27-33. 2012..Thus, these data suggest that the activation of GABA(A) receptors in the LS increases aggression regardless of whether or not a hamster has previously experienced social defeat...
- PER2 rhythms in the amygdala and bed nucleus of the stria terminalis of the diurnal grass rat (Arvicanthis niloticus)Chidambaram Ramanathan
Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
Neurosci Lett 473:220-3. 2010..These results are consistent with the hypothesis that diurnal behavior is associated with a phase change between the SCN and extra-SCN oscillators...
- Stress-induced relapse to drug seeking in the rat: role of the bed nucleus of the stria terminalis and amygdalaS Erb
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 De Maisonneuve Blvd W, Montreal, Que, Canada
Stress 4:289-303. 2001....
- Induction of θ-frequency oscillations in the rat medial septal diagonal band slice by metabotropic glutamate receptor agonistsC B Lu
Institue of Electrical Engineering, Yanshan University, Qinhuangdao, 066004, PR China
Neuroscience 177:1-11. 2011..These data demonstrate that DHPG-sensitive neuronal networks within medial septum generate theta rhythmic activity and are differentially modulated by excitatory and inhibitory ionotropic neurotransmissions...
- Medial septal/diagonal band cells express multiple functional nicotinic receptor subtypes that are correlated with firing frequencyJeffrey S Thinschmidt
Evelyn F and William L McKnight Brain Institute, Gainesville, FL 32610, USA
Neurosci Lett 389:163-8. 2005..Responses to ACh were not affected by tetrodotoxin (TTX) and CdC l(2) but were blocked by MLA or MLA and MEC, suggesting that these currents involve direct activation of nicotinic receptors...
- The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitroE N Karavaev
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia
Neurosci Behav Physiol 38:297-307. 2008..Cholinergic modulation of the responses of septal neurons to glutamate were shown to occur, as did modulation of the strength of the oscillatory properties of the septal network by nicotinic receptors...
- Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxietyK S Sink
Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
Mol Psychiatry 18:308-19. 2013....
- Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in ratsQing Liu
National Institute on Drug Dependence, Peking University, Beijing 100191, PR China
Brain Res 1454:90-9. 2012..Earlier observations have demonstrated that septal nuclei are critically involved in the processes of reward, learning and memory...
- Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalisL B M Resstel
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, USP, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, Sao Paulo, 14049 900, Brazil
Neuroscience 154:869-76. 2008..The results indicate that the BNST is engaged in behavioral responses elicited by punished stimuli and aversively conditioned contexts, reinforcing its proposed role in anxiety...
- Vasopressin and aggression in cross-fostered California mice (Peromyscus californicus) and white-footed mice (Peromyscus leucopus)J K Bester-Meredith
Department of Psychology, University of Wisconsin, 1202 W. Johnson Street, Madison, Wisconsin 53706, USA
Horm Behav 40:51-64. 2001....
- A functional glutamatergic neurone network in the medial septum and diagonal band areaF Manseau
Douglas Hospital Research Center, Department of Psychiatry, McGill University, 6875, LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
J Physiol 566:865-84. 2005..We propose that glutamatergic neurones within the MS/DB can excite cholinergic and GABAergic neurones, and that they are part of a connected excitatory network, which upon appropriate activation, may contribute to rhythm generation...
- Reduction of arginine vasopressin binding sites in mouse lateral septum by treatment with 6-hydroxydopamineH Ishizawa
Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, Bethesda, MD 20892
Brain Res 507:189-94. 1990..In contrast to the results with 6-hydroxydopamine, treatment of mice with 5,7-dihydroxytryptamine, to destroy serotonergic terminals, did not alter vasopressin binding in the lateral septum...
- Modulation of anxiety by mu-opioid receptors of the lateral septal region in miceJulie Le Merrer
Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite Bordeaux I, Avenue des Facultes, 33405 Talence, France
Pharmacol Biochem Behav 83:465-79. 2006..Taken together, these results suggest that LS mu-opioid receptors participate to the modulation of anxiety...
- Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypesJ D Guo
Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Neuroscience 164:1776-93. 2009..Hence, modulation of 5-HT(7) receptor activity in the BNST(ALG) may offer a novel avenue for the design of anxiolytic medications...
- A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalisRimi Hazra
Department of Psychiatry and Division of Behavioral Neuroscience and Psychiatric Disorders, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Mol Cell Neurosci 46:699-709. 2011....
- Effects of chronic stress on dendritic arborization in the central and extended amygdalaAjai Vyas
National Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS GKVK Campus, Bangalore 560065, India
Brain Res 965:290-4. 2003..While dendritic arborization in CeA neurons remains unaffected, it increases in BNST neurons after CIS. These results suggest a role for dendritic remodeling of BNST neurons in stress-induced facilitation of anxiety...
- Inputs to the ventrolateral bed nucleus of the stria terminalisJung Won Shin
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 511:628-57. 2008..In summary, the BSTvl receives inputs from a variety of brain sites implicated in hunger, salt and water intake, stress, arousal, and reward...
- Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumptionA E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Neuroscience 151:780-90. 2008..Taken together, these studies confirm the importance of lateral septum innervation by Ucn1 in the regulation of alcohol consumption...
- Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalisThomas L Kash
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Neuropsychopharmacology 34:2420-9. 2009....
- Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalisWalter Francesconi
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 29:5389-401. 2009..Thus, changes in the intrinsic properties of jcBNST neurons mediated by chronic activation of the CRF system may contribute to the persistent emotional dysregulation associated with protracted withdrawal...
- Restricted access to food, but not sucrose, saccharine, or salt, synchronizes the expression of Period2 protein in the limbic forebrainE Waddington Lamont
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, SP 244, Montreal, Quebec, Canada
Neuroscience 144:402-11. 2007....
- Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalisEric C Dumont
The Vollum Institute and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Nat Neurosci 8:413-4. 2005..There was no effect when cocaine or food was delivered passively, suggesting that synaptic plasticity in this area is involved in reward-seeking behaviors...
- Role of the bed nucleus of the stria terminalis in the control of ventral tegmental area dopamine neuronsMarion Jalabert
INSERM, U862, Neurocentre Magendie, Pathophysiology of Synaptic Plasticity Group, Bordeaux, F 33000, France
Prog Neuropsychopharmacol Biol Psychiatry 33:1336-46. 2009..We will discuss how changes in the activity of BST neurons projecting to the VTA could participate in the development or exacerbation of psychiatric conditions such as drug addiction...
- Human bed nucleus of the stria terminalis indexes hypervigilant threat monitoringLeah H Somerville
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire, USA
Biol Psychiatry 68:416-24. 2010....
- Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male ratsM Martinez
Department of Anatomy, and MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
Eur J Neurosci 10:20-33. 1998..As in our previous studies of repeated restraint, modulation in the expression of c-fos following repeated stress is highly regionally specific, suggesting that differential neural processing is involved in adaptation to social stress...
- Met-enkephalin immunoreactive neurons recruited by acute stress are innervated by axon terminals immunopositive for tyrosine hydroxylase and dopamine-alpha-hydroxylase in the anterolateral division of bed nuclei of the stria terminalis in the ratTamas Kozicz
University of Pecs, Medical Faculty, Department of Human Anatomy, Pecs, Szigeti ut 12, H 7624, Hungary
Eur J Neurosci 16:823-35. 2002..These interactions can be central in the modulatory control of the major stress regulatory pathway, the limbic hypothalamo-pituitary-adrenal axis...
- Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalisThomas L Kash
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Neuropsychopharmacology 33:1379-90. 2008..Finally, we demonstrate that ethanol inhibits NMDARs in cells in the vBNST that project to the VTA, providing a direct means by which ethanol in the vBNST can modulate the dopaminergic system...
- The lowest effective dose of fluoxetine in the forced swim test significantly affects the firing rate of lateral septal nucleus neurones in the ratC M Contreras
Laboratorio de Neurofarmacologia, Instituto de Neuroetologia, Universidad Veracruzana, Veracruz, Mexico
J Psychopharmacol 15:231-6. 2001..05). In conclusion, the increased neuronal tiring rate of the LSN in the animals treated with a low dose of fluoxetine may be associated with an increased motivation to escape from the stressful situation that the forced swim represents...
- Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behaviorSayamwong E Hammack
Department of Psychology, University of Vermont, Burlington, VT 05405, USA
Psychoneuroendocrinology 34:833-43. 2009....
- The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxietySayamwong E Hammack
Department of Psychology, University of Vermont, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:1309-20. 2009....
- Participation of the lateral septal nuclei (LSN) in the antidepressant-like actions of progesterone in the forced swimming test (FST)Erika Estrada-Camarena
Instituto de Neuroetologia, Universidad Veracruzana, Xalapa Ver, Mexico
Behav Brain Res 134:175-83. 2002The possible participation of lateral septal nuclei (LSN) in the antidepressant-like actions of progesterone was evaluated. The effect of different concentrations of progesterone (0.001, 0.01 and 0...
- Allopregnanolone microinjected into the lateral septum or dorsal hippocampus reduces immobility in the forced swim test: participation of the GABAA receptorJuan Francisco Rodríguez-Landa
Laboratorio de Neurofarmacologia, Instituto de Neuroetologia, Universidad Nacional Autonoma de Mexico, Xalapa, Veracruz, Mexico
Behav Pharmacol 20:614-22. 2009....
- A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorderRalf Brisch
Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 261:47-58. 2011The septal nuclei are assumed to play a significant role in the pathophysiology of schizophrenia and affective disorders...
- Involvement of rat lateral septum-acetylcholine pressor system in central amygdaloid nucleus-emotional pressor circuitYao Hua Li
Department of Physiology and Pathophysiology, Health Science Center, Peking University, 100083, Beijing, People s Republic of China
Neurosci Lett 323:60-4. 2002....
- Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axisMaría Inés Forray
Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile
Brain Res Brain Res Rev 47:145-60. 2004....
- Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulusG M Sullivan
Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 41, New York, NY 10032, USA
Neuroscience 128:7-14. 2004..The results are also not consistent with the hypothesis that BNST is only involved in unconditioned aspects of fear and anxiety...
- Androgens alter corticotropin releasing hormone and arginine vasopressin mRNA within forebrain sites known to regulate activity in the hypothalamic-pituitary-adrenal axisV Viau
Department of Physiology, University of California, San Francisco 94143-0444, USA
J Neuroendocrinol 13:442-52. 2001....
- Forebrain c-fos expression under conditions conducive to pair bonding in female prairie voles (Microtus ochrogaster)J Thomas Curtis
Department of Psychology and Neuroscience Program, Florida State University, 209 Copeland Avenue, Tallahassee, FL 32306, USA
Physiol Behav 80:95-101. 2003..We suggest that areas that show evidence of fos expression after sufficient time for pair bonding to occur may be important in the formation of associations between the partner and mating stimuli...
- Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalisRegula E Egli
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Neuropsychopharmacology 30:657-68. 2005..Further experiments demonstrate that the actions of NE on glutamatergic transmission can be correlated with beta-AR function...
- Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalisBrad A Grueter
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Neuropsychopharmacology 30:1302-11. 2005..In total, our data suggest a plausible site of action for some of the anxiolytic effects of group II and group III mGluR agonists...
- Paternal behavior influences development of aggression and vasopressin expression in male California mouse offspringCristianne R M Frazier
Department of Zoology, University of Wisconsin Madison, USA
Horm Behav 50:699-707. 2006..This study provides further evidence that paternal behavior influences the development of aggression and associated neural substrates...
- Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stressDavid A Morilak
Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, MC 7764, 7703 Floyd Curl Drive, 78229 3900, USA
Life Sci 73:715-26. 2003..Thus, the interaction of galanin and norepinephrine may be a viable target for the future development of novel therapeutic strategies for treating behavioral disorders related to stress or drug abuse...
- Estrogen receptor-alpha distribution in male rodents is associated with social organizationBruce S Cushing
The Brain Body Center, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Comp Neurol 494:595-605. 2006....
- Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stressSayamwong E Hammack
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
Behav Neurosci 118:443-8. 2004..BNST chemical lesion blocked the potentiation of freezing and the increases in escape latency that normally follow IS...
- Histological and cytological study of the bed nuclei of the stria terminalis in adult rat. II. Oval nucleus: extrinsic inputs, cell types, neuropil, and neuronal modulesJorge Larriva-Sahd
Instituto de Neurobiologia, UNAM, Juriquilla, Zona Centro Querétaro, CP 76001 Querétaro, Mexico
J Comp Neurol 497:772-807. 2006..The putative inputs from the major tracts of the forebrain coupled with the cytological organization of the Ov make it one of the most complex structures of the mammalian brain...
- Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administrationBrad A Grueter
Department of Molecular Physiology, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Neurosci 26:3210-9. 2006....
- Long-term effects of a single exposure to immobilization: a c-fos mRNA study of the response to the homotypic stressor in the rat brainAstrid Vallès
Departament de Biologia Cellular, de Fisiologia i d Immunologia, Unitat de Fisiologia Animal, Facultat de Ciències and Institut de Neurociènces, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
J Neurobiol 66:591-602. 2006....
- Organization of axonal projections from the anterolateral area of the bed nuclei of the stria terminalisHong Wei Dong
Neuroscience Program and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
J Comp Neurol 468:277-98. 2004..BSTal projections are distinct from those of the adjacent juxtacapsular, oval, fusiform, and rhomboid nuclei...
- Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar ratsMiguel Molina-Hernandez
Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicologicas, Universidad Veracruzana, Jalapa, Veracruz, Mexico
Prog Neuropsychopharmacol Biol Psychiatry 30:1129-35. 2006..0 microg/microl; P<0.05) in the same brain area. It is concluded that intra-lateral septal infusions of the mGlu5 receptor antagonist MTEP produced antidepressant-like actions or anxiolytic-like effects in male rats...
- BNST lesions aggravate behavioral despair but do not impair navigational learning in ratsPinar Pezuk
Psychobiology Laboratory, Department of Psychology, Bogazici University, 34342 Bebek, Istanbul, Turkey
Brain Res Bull 69:416-21. 2006..Experimentally induced depression by BNST lesions does not impair learning and memory in the water maze suggesting a possible dissociation between BNST-mediated depression and cognitive performance...
- Effects of BNST lesions in female rats on forced swimming and navigational learningPinar Pezuk
Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
Brain Res 1228:199-207. 2008....
- Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stressHabibeh Khoshbouei
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Neuropsychopharmacology 27:25-34. 2002..These results suggest that during stress, the neuropeptide galanin exerts a modulatory effect in the BSTL, facilitating behavioral and neuroendocrine components of the acute stress response...
- Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stressM Cecchi
Department of Pharmacology, MC 7764, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Neuroscience 112:13-21. 2002....
- Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of ratsC C Crestani
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
Br J Pharmacol 153:583-90. 2008..In the present study, we investigated the subtype of adrenoceptors that mediates the cardiovascular response to noradrenaline microinjection into the BST...
- Cardiovascular effects of noradrenaline microinjection in the bed nucleus of the stria terminalis of the rat brainC C Crestani
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
J Neurosci Res 85:1592-9. 2007..In conclusion, results indicate that microinjection of NA into the BST evokes pressor responses, which are mediated by acute vasopressin release...
- Bed nucleus of the stria terminalis N-methyl-D-aspartate receptors and nitric oxide modulate the baroreflex cardiac component in unanesthetized ratsFernando H F Alves
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
J Neurosci Res 87:1703-11. 2009..In conclusion, our data point out that local NMDA and nNOS interaction mediates the tonic inhibitory influence of the BST on the baroreflex bradycardiac response, modulating the parasympathetic cardiac activity...
- Morphine produces circuit-specific neuroplasticity in the bed nucleus of the stria terminalisE C Dumont
Department of Anesthesiology and Center for Neuroscience Studies, Queen s University, 99 University Avenue, Kingston, Ontario, Canada K7L 3N6
Neuroscience 153:232-9. 2008..Likewise, the inputs to neurons that did not project to the VTA were not changed by morphine. Altogether, these results extend the understanding of neuronal circuits intrinsically sensitive to drugs of abuse within the BST...
- Bed nucleus of the stria terminalis alpha(1)-adrenoceptor modulates baroreflex cardiac component in unanesthetized ratsCarlos C Crestani
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, São Paulo 14090 090, Brazil
Brain Res 1245:108-15. 2008..In conclusion, our data point out that local alpha(1)-adrenoceptors mediate the BST tonic influence on the baroreflex bradycardiac response modulating parasympathetic cardiac activity...
- Cannabinoid receptors in the bed nucleus of the stria terminalis control cortical excitation of midbrain dopamine cells in vivoLema Massi
Pathophysiology of Synaptic Plasticity Group, INSERM, U862, Neurocentre Magendie and Université de Bordeaux, Bordeaux, F 33000, France
J Neurosci 28:10496-508. 2008..Our data identify a new neuronal substrate for the actions of cannabinoids in the reward pathway...
- The bed nucleus of the stria terminalis modulates learning after stress in masculinized but not cycling femalesDebbie A Bangasser
Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
J Neurosci 28:6383-7. 2008..Importantly, together these studies indicate that males and females can engage different brain structures to modulate learning after a stressful experience...
- Involvement of hypothalamic paraventricular nucleus non-N-methyl-D-aspartate receptors in the pressor response to noradrenaline microinjected into the bed nucleus of the stria terminalis of unanesthetized ratsCarlos C Crestani
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, Sao Paulo 14049 900, Brazil
Eur J Neurosci 29:2166-76. 2009..They also suggest that a glutamatergic neurotransmission through non-NMDA glutamate receptors in the PVN mediates the response...
- Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatumChristopher M Olsen
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Physiol Genomics 32:283-98. 2008..Furthermore, these studies provide a framework for future mouse-mouse comparisons of transcriptional profiles after behavioral/pharmacological manipulation...
- Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST)Walter Francesconi
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:1347-55. 2009..These results provide a novel neurobiological target for vulnerability to alcohol and drug dependence...
- The Lateral Septum, Urocortin and AlcoholADAM WEITEMIER; Fiscal Year: 2004..First, the effect of CRF receptor ligands microinjected into the CRF2 receptor-rich lateral septal nuclei (LS) on alcohol consumption will be investigated...
- Perinatal choline therapy in a mouse model of Down Syndrome &Alzheimer's DiseaseBarbara J Strupp; Fiscal Year: 2012..abstract_text> ..
- Putting habenula pathways on the mapEric E Turner; Fiscal Year: 2013..analysis to test the hypothesis that key nodes of the habenula pathway, specifically the forebrain septal nuclei, LH, IP and RMTg, have distinctive gene expression profiles, as previously demonstrated for the MH...
- CENTER FOR THE STUDY OF EMOTION AND ATTENTIONPeter Lang; Fiscal Year: 2009..Finally, we will carry out brain imaging of odor-mediated fear retention, extinction, and conditioned inhibition in anesthetized rats usingfMRI in an 11 T magnet measured with blood pressure ..
- RAT MODEL OF FETAL ALCOHOL SYNDROMEASA BLACK; Fiscal Year: 1993....
- ATYPICAL ANTIPSYCHOTICS AND P50 GATING IN SCHIZOPHRENIALawrence Adler; Fiscal Year: 2001..He will also experiment with the multivariate statistical techniques needed to analyze multiunit data. ..
- THE ROLE OF PREPROTRH PEPTIDES IN COCAINE ACTIONKevin Sevarino; Fiscal Year: 2004..Further, acute cocaine caused significant regulation of TRH peptide levels in the nucleus accumbens, septal nuclei, and the hypothalamus, brain loci central to the limbic-motor circuit...
- TEMPORAL VULNERABILITY OF DEVELOPING RAT BRAIN TO ETOHASA BLACK; Fiscal Year: 1993..This research will help determine whether neurons exposed to ethanol during the period of their development are subject to greater damage than neurons born prior to exposure to ethanol...
- METABOTROPIC GLUTAMATE RECEPTORS AND EXCITOTOXICITYFang Zheng; Fiscal Year: 2007..The findings will provide critical information for developing drugs that can be used to treat Parkinson's diseases, seizures, psychosis and excitotoxicity associated with stroke. [unreadable] [unreadable]..
- Neuronal transport of gp120Italo Mocchetti; Fiscal Year: 2005..gp120 into the caudate nucleus or fimbria and examine gp120 immunoreactivity in the substantia nigra and septal nuclei, respectively...
- ELECTROPHYSIOLOGY OF SENSORY GATING IN SCHIZOPHRENIARobert Freedman; Fiscal Year: 1999....
- PROPAGATION OF EPILEPTIFORM DISCHARGERichard Miles; Fiscal Year: 1990..The association pathway linking different hippocampal lamellae will be stimulated in longitudinal slices and septal inputs will be examined in slices containing both the septal nuclei and the hippocampus.
- Neurobiology of Orexin/Hypocretin-Induced ArousalCRAIG BERRIDGE; Fiscal Year: 2004..These studies will provide a better understanding of the neurobiology of orexin, the neurobiology of sleep and waking, and the potential role of orexin in narcolepsy and other disorders of arousal. ..
- AMPHETAMINE-LIKE STIMULANTS: NOREPINEPHRINE & BEHAVIORCRAIG BERRIDGE; Fiscal Year: 2005..Information obtained in these studies may provide insight into mechanisms subserving, and treatment of, stimulant drug abuse. ..
- NEUROCHEMISTRY OF AMPHETAMINE INDUCED AROUSALCRAIG BERRIDGE; Fiscal Year: 2008..Information obtained in these studies may provide insight into mechanisms underlying, and future treatment of, stimulant drug abuse, ADHD and narcolepsy. ..
- Mechanisms of Basal Forebrain NeurodegenerationLUIS COLOM; Fiscal Year: 2004..Data from this work may contribute to the development of specific therapies designed to decrease neuronal dysfunction and vulnerability in AD. Furthermore, this work will contribute to our understanding of basal forebrain physiology. ..
- MBRS SCORE Program at the Univ of Texas-BrownsvilleLUIS COLOM; Fiscal Year: 2007..Furthermore, the success of this application will contribute to the development of internal collaborations and the necessary scientific environment to develop successful R01 applications in the near future. ..
- Estrogen receptors, photoperiod, and aggressionBRIAN TRAINOR; Fiscal Year: 2007..The proposed research should provide a novel and important framework to understand how the environment interacts with ER function to modulate behavior. ..
- Aromatase regulation of paternal behavior and aggressionBRIAN TRAINOR; Fiscal Year: 2002..In summary, this proposal examines how aromatase mediates the effects of testosterone and social behavior. ..
- LPH to VTA Neurotensin: Actions and Cocaine EffectsDANIEL ZAHM; Fiscal Year: 2004..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
- Narp Expression and Drugs of AbuseIrving Reti; Fiscal Year: 2002..B) Develop methods to manipulate expression of Narp in the VTA using the herpes simplex virus vector system. ..
- Form/function of Extended Amygdala/Accumbens Shell:CRFDANIEL ZAHM; Fiscal Year: 2005....
- Valence Coding and Regulation of Approach-Avoidance in Social and Asocial SpeciesJames L Goodson; Fiscal Year: 2010..We additionally propose the development of VT RNA interference that will enable us to specifically knock down VT production, thus allowing the functional investigation of specific VT cell groups. ..
- ELEMENTARY SCHOOL NEUROSCIENCE LITERACYGary Duncan; Fiscal Year: 2006..unreadable] [unreadable]..
- The Effect of Gonadal Steriods on Pavlovian Fear ConditioningMichael Davis; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Antipsychotic Actions in Models of NMDA HypofunctionGary Duncan; Fiscal Year: 2007..unreadable] [unreadable]..
- Ethanol sensitivity--native /recombinant NMDA receptorsJohn Woodward; Fiscal Year: 2006..The successful completion of this training plan will substantially enhance the PI's research expertise and his ability to fulfill the goals of his research. ..
- AAS and the Neurobiology of Social BehaviorsAnn Clark; Fiscal Year: 2009..Such data may be relevant towards understanding not only the effects of AAS, but of other abused drugs that act via GABAergic pathways. ..
- Opiate Addiction and HIV-1 Induced Release of CytokinesWilliam Banks; Fiscal Year: 2006....
- Synaptic Plasticity and Extinction of FearKerry Ressler; Fiscal Year: 2007..Emory University and the Center for Behavioral Neuroscience provide an excellent environment for career development and training in the field of behavioral neuroscience. ..
- Molecular Regulation of GABA(A) Receptor Function in AmygdalaKerry J Ressler; Fiscal Year: 2010..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..
- Anatomical Plasticity and HPA Axis DysfunctionJames Herman; Fiscal Year: 2009..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
- NPY Feeding Circuits during DevelopmentKevin Grove; Fiscal Year: 2007..Understanding of the normal and abnormal development of this circuitry is critical to determining the physiological mechanisms that underlie adult obesity and identify a critical period for possible intervention. ..
- Cholinergic and GABAergic Mechanisms in the Septohippocampal PathwayMeenakshi Alreja; Fiscal Year: 2010..The above hypothesis will be tested using electrophysiological, immunohistochemical and NO visualization techniques in rodent brain slices. ..
- Epigenetics of fetal alcohol syndromeFeng Zhou; Fiscal Year: 2009..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
- ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESISFeng Zhou; Fiscal Year: 2003....
- Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor CellsNuri Farber; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Neurodevelopmental ApoptosisNuri Farber; Fiscal Year: 2008..abstract_text> ..
- Glucocorticoid Receptor Mechanisms, Stress and AgingJames Herman; Fiscal Year: 2006..abstract_text> ..
- APOE EFFECT ON CNS NEURONS--ROLE OF LRPDavid Holtzman; Fiscal Year: 2003..These studies with physiological preparations of apoE as well as both in vivo and in vitro models should provide new insights into mechanisms underlying the link between apoE, LRP, ABeta, and Alzheimer's disease. ..
- PREFRONTAL CONTROL OF SOCIAL BEHAVIOR IN PRIMATESLorin Freedman; Fiscal Year: 2003..Activities are outlined over a five-year period that will provide the Principal Investigator a unique opportunity to develop as a research scientist and help to insure his success in academic neurology. ..
- Early Experience and Adult Responses to StressBrian Sanders; Fiscal Year: 2003..Consistent with the mission of the AREA program, this project will provide a significant training and educational opportunity for undergraduate students. ..
- PTS1 Regulation of Brain Met Enk Levels in AlcoholismWilliam Banks; Fiscal Year: 2004..abstract_text> ..
- CNS Estrogen Receptors and Social BehaviorBRUCE CUSHING; Fiscal Year: 2004....
- CORTICAL CIRCUITRY RELATED TO NEUROTRANSMISSION PROTEINSE Muly; Fiscal Year: 2004..The possibility of co-localization of the D1 receptor and the mGluR within a single spine will be examined. ..
- DEVELOPMENT OF THE GUSTATORY SYSTEMRICHARD NORTHCUTT; Fiscal Year: 2005..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
- Interaction of Brain Norepinephrine/Galanin in StressDavid Morilak; Fiscal Year: 2005..abstract_text> ..
- HIGH FREQUENCY BURST FIRING IN VISUAL CORTEXHal Blumenfeld; Fiscal Year: 2002..The information provided by these studies may yield insights into the mechanisms of normal cortical rhythmic oscillations, and suggest new therapies for the therapeutic management of epileptic seizures. ..
- The Delayed Effects of Phencyclidine: MechanismsSarah Turgeon; Fiscal Year: 2002..These experiments will begin to identify the mechanisms by which PCP produces schizophrenia-like behaviors in animals, providing insight into potential pathophysiologies underlying schizophrenia in humans. ..
- NGF effects on axonal growth in CNS white matterKeith Crutcher; Fiscal Year: 2006..The primary goal is to study the role of neurotrophic factors in stimulating axonal regeneration within CNS white matter. ..
- Modulation of BNST 5-HT responses by corticosteroneSAYAMWONG HAMMACK; Fiscal Year: 2006..unreadable] [unreadable]..
- NEUROBIOLOGICAL MECHANISMS OF ALCOHOL DRINKINGJames Smith; Fiscal Year: 2002..The proposed experiments will hopefully add significant new information to our understanding of the processes underlying alcohol abuse. ..
- Subcortical Estrogen Effect on The HippocampusCsaba Leranth; Fiscal Year: 2005..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
- COX-2 and Injury in the Immature BrainRobert Hickey; Fiscal Year: 2005..g., NSAIDS, steroids, etc.) can influence COX-2 production and isoform-specific COX-2 inhibitors have recently become clinically available. ..
- Androgenic And Antiandorgenic Interactions Of PC-SPESCHARLES ROSELLI; Fiscal Year: 2002..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
- NEUROCHEMICAL AND BEHAVIORAL EFFECTS OF HYPERGLYCEMIAMARISE PARENT; Fiscal Year: 2004..abstract_text> ..
- ETHANOL AND PREFRONTAL CORRELATES OF ATTENTIONBennet Givens; Fiscal Year: 2002....
- HORMONES AND BEHAVIORAL DEVELOPMENTBRUCE CUSHING; Fiscal Year: 2004....
- EFFECTS OF AGING & PGP ON AB EFFLUX FROM THE BRAINANNE FAGAN NIVEN; Fiscal Year: 2005..Support for the hypothesis would establish a role for age-dependent defects in A-beta clearance from the brain in the pathogenesis of AD and, importantly, provide a novel therapeutic target for treatment of the disease. ..
- NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIAAndrey Ryabinin; Fiscal Year: 2001..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
- Neurotransmission evoked by 5HT-dependent luminal factorYing Li; Fiscal Year: 2005..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
- Neural Analysis of Maternal AggressionSTEPHEN GAMMIE; Fiscal Year: 2006..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
- Exploratory Studies of Androgen Receptors in AxonsLydia Doncarlos; Fiscal Year: 2006..abstract_text> ..