gyrus cinguli

Summary

Summary: One of the convolutions on the medial surface of the cerebral hemisphere. It surrounds the rostral part of the brain and interhemispheric commissure and forms part of the limbic system.

Top Publications

  1. ncbi Neural activity in the human brain relating to uncertainty and arousal during anticipation
    H D Critchley
    Wellcome Department of Cognitive Neurology, 12 Queen Square, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
    Neuron 29:537-45. 2001
  2. ncbi Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032, USA
    Neuron 51:871-82. 2006
  3. ncbi Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
  4. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
  5. ncbi Conflict monitoring and anterior cingulate cortex: an update
    Matthew M Botvinick
    University of Pennsylvania, Center for Cognitive Neuroscience, 3720 Walnut Street, Philadelphia, PA 10104 6241, USA
    Trends Cogn Sci 8:539-46. 2004
  6. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
  7. ncbi Anterior cingulate conflict monitoring and adjustments in control
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Science 303:1023-6. 2004
  8. ncbi Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
  9. ncbi Anterior cingulate cortex, error detection, and the online monitoring of performance
    C S Carter
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Science 280:747-9. 1998
  10. ncbi Does rejection hurt? An FMRI study of social exclusion
    Naomi I Eisenberger
    Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Science 302:290-2. 2003

Research Grants

  1. FDG PET Study of Laboratory Induced Aggression
    Antonia New; Fiscal Year: 2007
  2. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
  3. Investigation and treatment of central nervous system dysfunction in chronic pelv
    Felipe Fregni; Fiscal Year: 2010
  4. Lifestyle Modification and blood Pressure Study (LIMBS)
    Debbie L Cohen; Fiscal Year: 2013
  5. Prediction of cognitive decline with structural, diffusion, and perfusion MRI
    Michael W Weiner; Fiscal Year: 2013
  6. Histologically validated structural MR imaging biomarkers for Alzheimers Disease
    Jonathan J Wisco; Fiscal Year: 2012
  7. COMPUTERIZED IMAGE ANALYSES OF MR SCANS IN SCHIZOPHRENIA
    Martha Shenton; Fiscal Year: 2009
  8. Neural Correlates of Language and Communication in Apes
    William D Hopkins; Fiscal Year: 2011
  9. Longitudinal imaging in adolescents prodromal for schizophrenia
    Tiziano Colibazzi; Fiscal Year: 2013
  10. The neural substrates of repetitive behaviors in autism
    Kelli Dominick; Fiscal Year: 2010

Detail Information

Publications312 found, 100 shown here

  1. ncbi Neural activity in the human brain relating to uncertainty and arousal during anticipation
    H D Critchley
    Wellcome Department of Cognitive Neurology, 12 Queen Square, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
    Neuron 29:537-45. 2001
    ..Our findings highlight distinct contributions of cognitive uncertainty and autonomic arousal to anticipatory neural activity in prefrontal cortex...
  2. ncbi Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032, USA
    Neuron 51:871-82. 2006
    ..These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex...
  3. ncbi Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
    ..It was hypothesized that the default mode network would show abnormal activation and connectivity in patients with schizophrenia...
  4. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
    ....
  5. ncbi Conflict monitoring and anterior cingulate cortex: an update
    Matthew M Botvinick
    University of Pennsylvania, Center for Cognitive Neuroscience, 3720 Walnut Street, Philadelphia, PA 10104 6241, USA
    Trends Cogn Sci 8:539-46. 2004
    ..Recent research has also begun to shed light on the larger function of the ACC, suggesting some new possibilities concerning how conflict monitoring might fit into the cingulate's overall role in cognition and action...
  6. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
    ..We conclude that only that part of the pain network associated with its affective qualities, but not its sensory qualities, mediates empathy...
  7. ncbi Anterior cingulate conflict monitoring and adjustments in control
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Science 303:1023-6. 2004
    ....
  8. ncbi Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
    ....
  9. ncbi Anterior cingulate cortex, error detection, and the online monitoring of performance
    C S Carter
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Science 280:747-9. 1998
    ..This suggests that the ACC detects conditions under which errors are likely to occur rather than errors themselves...
  10. ncbi Does rejection hurt? An FMRI study of social exclusion
    Naomi I Eisenberger
    Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Science 302:290-2. 2003
    ..ACC changes mediated the RVPFC-distress correlation, suggesting that RVPFC regulates the distress of social exclusion by disrupting ACC activity...
  11. pmc Pain and emotion interactions in subregions of the cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute and SUNY Upstate Medical University, Department of Neuroscience and Physiology, 4435 Stephanie Drive, Manlius, New York 13104, USA
    Nat Rev Neurosci 6:533-44. 2005
    ..Here, we assess pain and emotion in each cingulate subregion, and assess whether pain is co-localized with negative affect. Amazingly, these activation patterns do not simply overlap...
  12. pmc Reproducibility of quantitative tractography methods applied to cerebral white matter
    Setsu Wakana
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD 21205, USA
    Neuroimage 36:630-44. 2007
    ..Hemispheric asymmetry was observed for the size of white matter tracts projecting to the temporal lobe. This protocol provides guidelines for reproducible DTI-based tract-specific quantification...
  13. ncbi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  14. ncbi Optimal decision making and the anterior cingulate cortex
    Steven W Kennerley
    Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 9:940-7. 2006
    ..These data suggest that the ACC is essential for learning the value of actions...
  15. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  16. pmc The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
    ..These data thus hold important implications for the development of neural models of depression that can account for the abnormal motivational, neuroendocrine, autonomic, and emotional manifestations evident in human mood disorders...
  17. ncbi Placebo-induced changes in FMRI in the anticipation and experience of pain
    Tor D Wager
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Science 303:1162-7. 2004
    ....
  18. ncbi Placebo and opioid analgesia-- imaging a shared neuronal network
    Predrag Petrovic
    Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
    Science 295:1737-40. 2002
    ..These findings indicate a related neural mechanism in placebo and opioid analgesia...
  19. ncbi Primate anterior cingulate cortex: where motor control, drive and cognition interface
    T Paus
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
    Nat Rev Neurosci 2:417-24. 2001
    ..I argue that the overlap of these three domains is key to distinguishing the anterior cingulate cortex from other frontal regions, placing it in a unique position to translate intentions to actions...
  20. ncbi Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction
    H Garavan
    Department of Psychology, Trinity College Dublin, Dublin 2, Ireland
    Neuroimage 17:1820-9. 2002
    ..The results highlight how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems...
  21. ncbi Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
    Teresa R Franklin
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 51:134-42. 2002
    ..To date, a focal structural analysis of the brains of cocaine patients has not been undertaken...
  22. pmc Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network
    Robyn L Bluhm
    Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Schizophr Bull 33:1004-12. 2007
    ..Because these data suggest significant abnormalities in resting-state neural networks in schizophrenia, further investigations of spontaneous slow fluctuations of the BOLD signal seem warranted in this population...
  23. ncbi Learned predictions of error likelihood in the anterior cingulate cortex
    Joshua W Brown
    Department of Psychology, CB 1125, Washington University, St Louis, MO 63130, USA
    Science 307:1118-21. 2005
    ..These results support a more general error-likelihood theory of ACC function based on reinforcement learning, of which conflict and error detection are special cases...
  24. pmc Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users
    Robert Hester
    Department of Psychology, University of Melbourne, Melbourne, Victoria, Australia
    Neuropsychopharmacology 34:2450-8. 2009
    ....
  25. ncbi Increased neural resources recruitment in the intrinsic organization in major depression
    Yuan Zhou
    Center for Social and Economic Behavior, Institute of Psychology, Chinese Academy of Sciences, Beijing 100190, PR China
    J Affect Disord 121:220-30. 2010
    ....
  26. ncbi The role of cingulate cortex in the detection of errors with and without awareness: a high-density electrical mapping study
    Redmond G O'Connell
    Department of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Eur J Neurosci 25:2571-9. 2007
    ..These findings may be particularly important in the context of clinical studies in which a proper understanding of self-monitoring deficits requires an explicit measurement of error awareness...
  27. ncbi Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:7385-92. 2005
    ..This suggests that synaptic plasticity in the ACC and amygdala of FMR1 KO mice plays an important role in the expression of behavioral phenotypes similar to the symptoms of fragile X syndrome...
  28. ncbi Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder
    Lixia Tian
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China
    Neurosci Lett 400:39-43. 2006
    ..We suggest these abnormally more significant functional connectivities in the ADHD patients may indicate the abnormality of autonomic control functions in them...
  29. pmc Dorsal anterior cingulate cortex: a role in reward-based decision making
    George Bush
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:523-8. 2002
    ..These findings should be of interest to those studying reward, cognition, emotion, motivation, and motor control...
  30. pmc Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
  31. ncbi Asymmetry analysis of cingulum based on scale-invariant parameterization by diffusion tensor imaging
    Gaolang Gong
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Hum Brain Mapp 24:92-8. 2005
    ..More interestingly, a significant left-greater-than-right asymmetry pattern was obtained in most segments of cingulum bundle (-50-25 degrees), except in the most posterior portion of cingulum (25-50 degrees)...
  32. pmc Neuronal basis of sequential foraging decisions in a patchy environment
    Benjamin Y Hayden
    Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, USA
    Nat Neurosci 14:933-9. 2011
    ..These findings portend an understanding of the neural basis of foraging decisions and endorse the unification of theoretical and experimental work in ecology and neuroscience...
  33. ncbi Mapping the functional connectivity of anterior cingulate cortex
    Daniel S Margulies
    The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA
    Neuroimage 37:579-88. 2007
    ..We discuss the implications of our work for understanding ACC function and potential applications to clinical populations...
  34. ncbi Performance monitoring by the anterior cingulate cortex during saccade countermanding
    Shigehiko Ito
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Wilson Hall, Vanderbilt University, Nashville, TN 37203, USA
    Science 302:120-2. 2003
    ..No neurons signaled the form of conflict engendered by interruption of saccade preparation produced in this task. These results are consistent with the hypothesis that the anterior cingulate cortex monitors the consequences of actions...
  35. ncbi Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study
    Su Lui
    Huaxi MR Research Center HMRRC, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, PR China
    Am J Psychiatry 166:196-205. 2009
    ....
  36. ncbi Performance monitoring in the anterior cingulate is not all error related: expectancy deviation and the representation of action-outcome associations
    Flavio T P Oliveira
    Simon Fraser University, Burnaby, British Columbia, Canada
    J Cogn Neurosci 19:1994-2004. 2007
    ..These results could shed light into neurobehavioral disorders, such as depression and mania, associated with alterations in performance monitoring and also in judgments of self-related events...
  37. pmc Nicotine enhances visuospatial attention by deactivating areas of the resting brain default network
    Britta Hahn
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 27:3477-89. 2007
    ..Together with the selectivity of effects for INT(high), this suggests a nicotine-induced potentiation of the alerting properties of external stimuli...
  38. ncbi The counting Stroop: an interference task specialized for functional neuroimaging--validation study with functional MRI
    G Bush
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    Hum Brain Mapp 6:270-82. 1998
    ..These findings have ramifications for attentional, cognitive interference, learning, and motor control mechanism theories...
  39. ncbi Cingulate hypoactivity in cocaine users during a GO-NOGO task as revealed by event-related functional magnetic resonance imaging
    Jacqueline N Kaufman
    Medical College of Wisconsin, Department of Psychiatry, Milwaukee, Wisconsin 53226, USA
    J Neurosci 23:7839-43. 2003
    ..The results suggest that addiction may be accompanied by a disruption of brain structures critical for the higher-order, cognitive control of behavior...
  40. ncbi Subprocesses of performance monitoring: a dissociation of error processing and response competition revealed by event-related fMRI and ERPs
    M Ullsperger
    Max Planck Institute of Cognitive Neuroscience, D-04303 Leipzig, Germany
    Neuroimage 14:1387-401. 2001
    ..Further fMRI activations in the lateral prefrontal and primary motor cortex are discussed with respect to performance monitoring and its influence on task set reconfiguration...
  41. pmc The neurobiology of cognitive control in successful cocaine abstinence
    Colm G Connolly
    Department of Psychiatry, University of California, San Diego, USA
    Drug Alcohol Depend 121:45-53. 2012
    ..Relatively little is known about the cognitive sequelae of long-term abstinence in cocaine addicts...
  42. ncbi Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    ..Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings...
  43. pmc Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation
    Sameer A Sheth
    Nayef Al Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 488:218-21. 2012
    ..In situations with stable cognitive demands, this signal promotes efficiency by hastening responses, but in situations with changing demands it engenders accuracy by delaying responses...
  44. pmc Encoding of reward and space during a working memory task in the orbitofrontal cortex and anterior cingulate sulcus
    Steven W Kennerley
    Department of Psychology, University of California, Berkeley, CA 94720 3190, USA
    J Neurophysiol 102:3352-64. 2009
    ..They also suggest that neither PFo nor PFcs play a direct role in the control of spatial attention...
  45. pmc Error effects in anterior cingulate cortex reverse when error likelihood is high
    Ryan K Jessup
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, USA
    J Neurosci 30:3467-72. 2010
    ..These findings provide perspective on recent ERP studies and suggest that mPFC error effects result from a comparison between actual and expected outcomes...
  46. ncbi Prefrontal-cingulate interactions in action monitoring
    W J Gehring
    Department of Psychology, University of Michigan, 525 East University Avenue, Ann Arbor, Michigan 48109 1109, USA
    Nat Neurosci 3:516-20. 2000
    ..Lateral prefrontal damage also affected corrective behavior. Thus the lateral prefrontal cortex seemed to interact with the anterior cingulate cortex in monitoring behavior and in guiding compensatory systems...
  47. ncbi Abstract reward and punishment representations in the human orbitofrontal cortex
    M L Kringelbach
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 4:95-102. 2001
    ..These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money...
  48. ncbi The subcallosal cingulate gyrus in the context of major depression
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Biol Psychiatry 69:301-8. 2011
    ..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region...
  49. pmc Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:15700-5. 2005
    ..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses...
  50. pmc Fictive reward signals in the anterior cingulate cortex
    Benjamin Y Hayden
    Department of Neurobiology, Duke University School of Medicine, Center for Neuroeconomic Studies, Center for Cognitive Neuroscience, Duke University, Durham, NC 27701, USA
    Science 324:948-50. 2009
    ..We found that ACC neurons signal fictive reward information and use a coding scheme similar to that used to signal experienced outcomes. Thus, individual ACC neurons process both experienced and fictive rewards...
  51. ncbi Sites of neocortical reorganization critical for remote spatial memory
    Thibault Maviel
    Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence, France
    Science 305:96-9. 2004
    ..Thus, consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently...
  52. ncbi A meta-analysis of instructed fear studies: implications for conscious appraisal of threat
    Marie Luise Mechias
    Institute for Systems Neuroscience and NeuroImage Nord Hamburg Kiel Lübeck, University Medical Center Hamburg Eppendorf UKE, Martinistr 52, 20246 Hamburg, Germany
    Neuroimage 49:1760-8. 2010
    ..These data suggest that mid regions of the dmPFC/dACC are part of a "core" fear network that is activated irrespective of how fear was learnt...
  53. pmc Double dissociation of value computations in orbitofrontal and anterior cingulate neurons
    Steven W Kennerley
    Institute of Neurology, University College London, London, UK
    Nat Neurosci 14:1581-9. 2011
    ....
  54. ncbi The medial frontal cortex and the rapid processing of monetary gains and losses
    William J Gehring
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Science 295:2279-82. 2002
    ..It follows that medial-frontal computations may contribute to mental states that participate in higher level decisions, including economic choices...
  55. ncbi Decreased anterior cingulate volume in combat-related PTSD
    Steven H Woodward
    Clinical Laboratory and Education Division and Psychology Service, National Center for PTSD, VA Palo Alto Healthcare System, Palo Alto, California 94034, USA
    Biol Psychiatry 59:582-7. 2006
    ..We explored associations between PTSD and ACC volume in a relatively large sample of adult combat veterans in which PTSD, lifetime alcohol abuse/dependence, and Vietnam versus Gulf War service were crossed...
  56. pmc Dissociation between conflict detection and error monitoring in the human anterior cingulate cortex
    Diane Swick
    Department of Neurology 127E, Veterans Affairs Northern California Health Care System, University of California at Davis, 150 Muir Road, Martinez, CA 94553, USA
    Proc Natl Acad Sci U S A 99:16354-9. 2002
    ..The results implicate rostral-dorsal ACC in error monitoring and suggest this function can be dissociated from conflict-detection processes...
  57. ncbi Architecture and connections of retrosplenial area 30 in the rhesus monkey (Macaca mulatta)
    R Morris
    Montreal Neurological Institute, Department of Neurology, McGill University, Montreal, QC, Canada H3A 2B4
    Eur J Neurosci 11:2506-18. 1999
    ..The connectivity of area 30 suggests that it may play a role in working memory processes subserved by the mid-dorsolateral frontal cortex in interaction with the hippocampal system...
  58. pmc Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 63:550-6. 2008
    ..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD...
  59. pmc Anticipation of conflict monitoring in the anterior cingulate cortex and the prefrontal cortex
    Myeong Ho Sohn
    Department of Psychology, George Washington University, Washington, DC 20052, USA
    Proc Natl Acad Sci U S A 104:10330-4. 2007
    ....
  60. pmc Involvement of the rostral anterior cingulate cortex in consolidation of inhibitory avoidance memory: interaction with the basolateral amygdala
    Emily L Malin
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 87:295-302. 2007
    ....
  61. ncbi Interactions between decision making and performance monitoring within prefrontal cortex
    Mark E Walton
    Department of Experimental Psychology, South Parks Road, Oxford, OX1 3UD, England, UK
    Nat Neurosci 7:1259-65. 2004
    ..These results indicate that the neural mechanisms underlying the way we assess the consequences of choices differ depending on whether we are told what to do or are able to exercise our volition...
  62. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  63. pmc Structural and functional dichotomy of human midcingulate cortex
    Brent A Vogt
    Cingulum NeuroSciences Institute and Cingulate NeuroTherapeutics, 4435 Stephanie Drive, Manlius, NY 13104, USA
    Eur J Neurosci 18:3134-44. 2003
    ..The MCC dichotomy suggests that two circuits differentially regulate the two cingulate motor areas, and involvement of aMCC in pain and fear make it selectively vulnerable to chronic pain and stress syndromes...
  64. ncbi Depression-related variation in brain morphology over 3 years: effects of stress?
    Thomas S Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 65:1156-65. 2008
    ..Results of experimental studies suggest that neuroplastic changes may occur during depressive episodes. These effects have not been confirmed in patients with depression, to our knowledge...
  65. pmc Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
    Marek Kubicki
    Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System Brockton Division, and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts 02301, USA
    Biol Psychiatry 54:1171-80. 2003
    ..These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities...
  66. ncbi Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity
    Robert Hester
    Department of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neurosci 24:11017-22. 2004
    ..The results reveal a neuroanatomical basis for this dysexecutive component to addiction, supporting the suggested importance cognitive functions may play in prolonging abuse or predisposing users toward relapse...
  67. ncbi Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder
    Kate Dimond Fitzgerald
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 48109 0118, USA
    Biol Psychiatry 57:287-94. 2005
    ..In this functional magnetic resonance imaging (fMRI) study, we sought to further localize error-processing differences within the ACC of OCD patients compared with healthy subjects...
  68. ncbi Electrophysiological responses to errors and feedback in the process of action regulation
    Phan Luu
    Electrical Geodesics, Inc, Eugene, Oregon 97403, USA
    Psychol Sci 14:47-53. 2003
    ..These results suggest that action regulation by the cingulate gyrus may require the entrainment of multiple structures of the Papez corticolimbic circuit...
  69. ncbi Neurocognitive correlates of liberalism and conservatism
    David M Amodio
    Department of Psychology, New York University, 6 Washington Place, New York, New York 10003, USA
    Nat Neurosci 10:1246-7. 2007
    ....
  70. ncbi Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention
    Katya Rubia
    Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, King s College, 16 De Crespigny Park, London, SE5 8AF, UK
    Am J Psychiatry 166:83-94. 2009
    ....
  71. pmc Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 106:9453-8. 2009
    ..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction...
  72. ncbi Anterior cingulate activity as a predictor of degree of treatment response in major depression: evidence from brain electrical tomography analysis
    D Pizzagalli
    Department of Psychology, University of Wisconsin, Madison 53706, USA
    Am J Psychiatry 158:405-15. 2001
    ..Whereas prior studies used hemodynamic imaging, this investigation used EEG...
  73. pmc Neural circuitry of emotional and cognitive conflict revealed through facial expressions
    Kimberly S Chiew
    Department of Psychology, Washington University in St Louis, St Louis, Missouri, United States of America
    PLoS ONE 6:e17635. 2011
    ....
  74. ncbi Abnormal anterior cingulum integrity in first episode, early-onset schizophrenia: a diffusion tensor imaging study
    Jinsong Tang
    The Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China
    Brain Res 1343:199-205. 2010
    ..These findings indicate that white matter abnormalities in the anterior cingulum are associated with adolescent EOS...
  75. pmc Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
    Daejong Jeon
    Center for Neural Science, Korea Institute of Science and Technology, Seoul, Korea
    Nat Neurosci 13:482-8. 2010
    ..These results demonstrate the functional involvement of the affective pain system and Ca(v)1.2 channels of the ACC in observational social fear...
  76. ncbi BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects
    L Gerritsen
    Department of Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Psychiatry 17:597-603. 2012
    ..Given the key role of the subgenual ACC in emotion regulation, this finding provides an important mechanistic link between stress and BDNF on one hand and mood impairments on the other hand...
  77. ncbi Amygdala and anterior cingulate cortex activation during affective startle modulation: a PET study of fear
    Anna Pissiota
    Department of Psychology, Uppsala University, Uppsala, Sweden
    Eur J Neurosci 18:1325-31. 2003
    ..Thus, we suggest that the amygdaloid area and the ACC form part of a neural system dedicated to attention and orientation to danger, and that this network modulates startle during negative affect...
  78. pmc Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
    ..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC...
  79. pmc Remembering beauty: roles of orbitofrontal and hippocampal regions in successful memory encoding of attractive faces
    Takashi Tsukiura
    Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA
    Neuroimage 54:653-60. 2011
    ..These results suggest that better memory for attractive faces reflects greater interaction between a region associated with reward, the orbitofrontal cortex, and a region associated with successful memory encoding, the hippocampus...
  80. ncbi Functional segregation of the human cingulate cortex is confirmed by functional connectivity based neuroanatomical parcellation
    Chunshui Yu
    Department of Radiology, Tianjin Medical University General Hospital, Heping District, Tianjin, China
    Neuroimage 54:2571-81. 2011
    ....
  81. pmc Functional connectivity of default mode network components: correlation, anticorrelation, and causality
    Lucina Q Uddin
    The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, New York 10016, USA
    Hum Brain Mapp 30:625-37. 2009
    ..Thus, the two major nodes comprising the DMN are differentiated with respect to the specific brain systems with which they interact, suggesting greater heterogeneity within this network than is commonly appreciated...
  82. ncbi Where and when the anterior cingulate cortex modulates attentional response: combined fMRI and ERP evidence
    S Crottaz-Herbette
    Department of Psychiatry and Behavioural Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cogn Neurosci 18:766-80. 2006
    ..Our findings suggest a model of attentional control based on dynamic bottom-up and top-down interactions between the ACC and primary sensory regions...
  83. ncbi Comparing the prefrontal cortex of rats and primates: insights from electrophysiology
    Jeremy K Seamans
    Department of Psychiatry and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T2B5
    Neurotox Res 14:249-62. 2008
    ..In primates, these functions may have formed the building blocks required for abstract rule encoding during the expansion of the cortex dorsolaterally...
  84. ncbi Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation
    Bihua Bie
    Department of General Anesthesiology, Institute of Anesthesiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur J Pharmacol 653:26-31. 2011
    ..This investigation may clarify, at least partially, the underlying supraspinal mechanism for adaptation of glutamatergic transmission during chronic pain induced by peripheral inflammation...
  85. ncbi Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex
    J K Seamans
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Neurosci 109:1063-73. 1995
    ....
  86. ncbi Context-dependent cortical activation in response to financial reward and penalty: an event-related fMRI study
    Yuko Akitsuki
    Department of Psychiatry, NICHe, Tohoku University Graduate School of Medicine, Aoba 10, Aramaki, Aoba ku, Sendai, Miyagi 980 8579, Japan
    Neuroimage 19:1674-85. 2003
    ..These context-dependent activities appear to be crucial for adapting oneself to new circumstances and may account for clinical symptoms of various mental illnesses in which dysfunction of these regions has been reported...
  87. pmc Neural foundations to moral reasoning and antisocial behavior
    Adrian Raine
    Department of Psychology and Neuroscience Program, University of Southern California, USA
    Soc Cogn Affect Neurosci 1:203-13. 2006
    ..While this neurobiological predisposition is likely only one of several biosocial processes involved in the etiology of antisocial behavior, it raises significant moral issues for the legal system and neuroethics...
  88. ncbi Differential sex-independent amygdala response to infant crying and laughing in parents versus nonparents
    Erich Seifritz
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Biol Psychiatry 54:1367-75. 2003
    ..Here, we hypothesized that human brain response to emotional stimuli relevant for social interactions between infants and adults are modulated by sex- and experience-dependent factors...
  89. ncbi Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Cell Physiol 211:336-43. 2007
    ....
  90. ncbi Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy
    Angela Merkl
    Department of Psychiatry Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Biol Psychiatry 69:772-9. 2011
    ....
  91. ncbi On the role of serotonin and effort in voluntary attention: evidence of genetic variation in N1 modulation
    Sören Enge
    Technische Universitat Dresden, Institut für Psychologie II, Differentielle und Persönlichkeitspsychologie, 01062 Dresden, Germany
    Behav Brain Res 216:122-8. 2011
    ..We suggest that the observed interaction mirrors the interplay between effort-mediated top-down attention by the ACC and serotonergic adjustment on attentional systems...
  92. ncbi Brain mechanisms of pain affect and pain modulation
    Pierre Rainville
    Département de Stomatologie, Faculte de Medecine Dentaire, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Curr Opin Neurobiol 12:195-204. 2002
    ....
  93. pmc Neural activation during encoding of emotional faces in pediatric bipolar disorder
    Daniel P Dickstein
    Division of Intramural Research Program, National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, Bethesda, MD 20892 2670, USA
    Bipolar Disord 9:679-92. 2007
    ..To begin to address these limitations, the current study tests the hypothesis that pediatric BD (PBD) subjects exhibit altered neural activation during encoding of emotional faces compared to typically developing controls...
  94. pmc Rostral Cingulate Zone and correct response monitoring: ICA and source localization evidences for the unicity of correct- and error-negativities
    Clémence Roger
    Laboratoire de Neurobiologie de la Cognition, Aix Marseille Universite, CNRS, Marseille, France
    Neuroimage 51:391-403. 2010
    ..These data suggest that the waves on errors and correct trials reflect the same brain activity, whose amplitude varies as a function of the correctness of the response. The implications of this result for cognitive control are discussed...
  95. pmc 1H-MRS at 4 tesla in minimally treated early schizophrenia
    J R Bustillo
    Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Mol Psychiatry 15:629-36. 2010
    ..We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity...
  96. pmc Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
    ....
  97. pmc Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder
    Fei Wang
    Department of Psychiatry, Yale School of Medicine, 300 George Street, Suite 901, New Haven CT 06511, USA
    Biol Psychiatry 66:516-21. 2009
    ..This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD...
  98. ncbi Subgenual cingulate activity reflects individual differences in empathic concern
    Roland Zahn
    The University of Manchester, School of Psychological Sciences, Neuroscience and Aphasia Research Unit, Manchester, M13 9PL, UK
    Neurosci Lett 457:107-10. 2009
    ..These results shed new light on the role of the SCC which shows abnormalities in clinical depression...
  99. ncbi Anterior cingulate cortex modulates visceral pain as measured by visceromotor responses in viscerally hypersensitive rats
    Zhijun Cao
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 134:535-43. 2008
    ..We aimed to determine if ACC neuron activation enhances visceral pain in viscerally hypersensitive rats and to identify the receptor involved in facilitation of visceral pain...
  100. ncbi Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD
    Kathleen Thomaes
    GGZ inGeest, Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 71:1636-44. 2010
    ..We investigated whether child abuse-related complex PTSD--a severe form of PTSD with affect dysregulation and high comorbidity--showed similar brain volume reductions...
  101. pmc Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
    ..These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders...

Research Grants64

  1. FDG PET Study of Laboratory Induced Aggression
    Antonia New; Fiscal Year: 2007
    ..abstract_text> ..
  2. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
    ..The planned studies are expected to yield new information concerning altered processing of emotional stimuli and behavioral disinhibition in young adults at high risk for future alcoholism. ..
  3. Investigation and treatment of central nervous system dysfunction in chronic pelv
    Felipe Fregni; Fiscal Year: 2010
    ....
  4. Lifestyle Modification and blood Pressure Study (LIMBS)
    Debbie L Cohen; Fiscal Year: 2013
    ....
  5. Prediction of cognitive decline with structural, diffusion, and perfusion MRI
    Michael W Weiner; Fiscal Year: 2013
    ..This application uses MRI scanning to "predict cognitive decline" in nondemented elders and will lead to methods which identify subjects at risk, who can then be put on preventive treatment once it's available. ..
  6. Histologically validated structural MR imaging biomarkers for Alzheimers Disease
    Jonathan J Wisco; Fiscal Year: 2012
    ..We expect that the validated biomarker created through this project will assist with the diagnosis and prognosis of AD, thereby facilitating more treatment options for patients who are afflicted. ..
  7. COMPUTERIZED IMAGE ANALYSES OF MR SCANS IN SCHIZOPHRENIA
    Martha Shenton; Fiscal Year: 2009
    ..Through the use of such advanced neuroimaging techniques, our long-term goal is to understand the neuropathology of schizophrenia. ..
  8. Neural Correlates of Language and Communication in Apes
    William D Hopkins; Fiscal Year: 2011
    ..Overall, the proposed research will lead a better understanding of factors which influence the development of the central nervous system and its behavioral and communicative correlates. ..
  9. Longitudinal imaging in adolescents prodromal for schizophrenia
    Tiziano Colibazzi; Fiscal Year: 2013
    ..This project is relevant to the mission of this agency, being one of the areas of "increased research emphasis" for NIMH. ..
  10. The neural substrates of repetitive behaviors in autism
    Kelli Dominick; Fiscal Year: 2010
    ..This research will inform our understanding of the biological basis of both repetitive behavior and autism, leading to better treatments and more directed genetic research. ..
  11. Cognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCD
    JOSEPH O'NEILL; Fiscal Year: 2013
    ....
  12. Attentional Bias Modification: Efficacy and Mechanisms of Action in Cocaine Addic
    ANDREW ROBERT MAYER; Fiscal Year: 2013
    ....
  13. MULTIFOCAL NEURODEGENERATION IN ALZHEIMER'S DISEASE
    Brent Vogt; Fiscal Year: 2002
    ....
  14. CORTICOSPINAL CONTROL OF FORELIMB MOVEMENT
    Paul Cheney; Fiscal Year: 2002
    ..The goal of this proposal will be to apply the techniques of spike and stimulus triggered averaging of EMG activity to map and assess the functional nature of these multiple corticospinal forelimb representations. ..
  15. TEMPORAL LOBE INPUT TO THE DESCENDING MOTOR PATHWAYS
    ROBERT MORECRAFT; Fiscal Year: 2001
    ....
  16. CORTICOLIMBIC DEGENERATION AND TREATMENT OF DEMENTIA
    John Csernansky; Fiscal Year: 2009
    ..Parallel studies of progressive amyloid plaque deposition and neuronal degeneration will be performed in transgenic mice (Tg2576) that express a mutant form of the APP gene. ..
  17. BRAIN MORPHOLGY IN OBSESSIVE-COMPULSIVE DISORDER
    Delbert Robinson; Fiscal Year: 1993
    ....
  18. BRAIN RESERVE, AGING, AND WORKING MEMORY
    Marc Haut; Fiscal Year: 1999
    ..abstract_text> ..
  19. CONNECTIONS OF THE CINGULATE GYRUS
    J Wyss; Fiscal Year: 1990
    ..These studies will elucidate the structure and function of the cingulate cortex, and the results will provide significant new information on which to base future studies on learning disorders and stress induced hypertension...
  20. Amygdalar and Thalamic Abnormalities in Schizophrenia
    Sabina Berretta; Fiscal Year: 2002
    ....
  21. CHOLINERGIC MODULATION OF NIGRAL DOPAMINE NEURONS
    Joseph Whittaker; Fiscal Year: 2003
    ..Results from the proposed studies may have clinical consequences relevant to symptomatic expression and pharmacological manipulations in motor and behavioral disorders such as Parkinson's disease. ..
  22. Cortico-Amygdalo-Thalamic Circuitry in Humans
    Sabina Berretta; Fiscal Year: 2007
    ..More in general, results obtained from the investigations described in this proposal will be relevant to the study of the physiological functions of AMYG and of its role in major psychiatric diseases. ..
  23. NEUROMODULATION, TOPOGRAPHY & SYMPTOMS IN SCHIZOPHRENIA
    Cameron Carter; Fiscal Year: 2000
    ....
  24. Declarative and Emotional Memory in Alzheimer's disease
    Pauline McHugh; Fiscal Year: 2004
    ....
  25. Impact of Stimulant Treatment on Neural Reward Circuitry Functioning in ADHD
    OLGA BERWID; Fiscal Year: 2009
    ....
  26. Face Affect Processing in Schizophrenia with MEG
    Stephen Lewis; Fiscal Year: 2006
    ..MEG analyses will be related to (1) an affect processing battery, (2) standard symptom scales, and (3) measures of quality of life for subjects with schizophrenia. ..
  27. MEDIAL FRONTAL CORTEX IN INTENTIONAL ASPECTS OF LANGUAGE
    Bruce Crosson; Fiscal Year: 1999
    ..Eventually, the tasks and procedures involved in this study can be used to study intentional activity in patients with language impairment because of brain injury or disease. ..
  28. SEX AND ATTENTION IN SCHIZOPHRENIA--APPLICATION OF FMRI
    Jill Goldstein; Fiscal Year: 1999
    ..Findings will contribute to an understanding of sex differences in the nature of schizophrenia, and how, or whether, they deviate from sex differences in the normal brain. ..
  29. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  30. Neuroimaging Studies of Frontal Lobe Pathology in OCD
    Philip Szeszko; Fiscal Year: 2005
    ....
  31. Diffusion Tensor Imaging in First-Episode Schizophrenia
    Philip R Szeszko; Fiscal Year: 2010
    ..The identification of these abnormalities at the first episode of illness may be useful for identifying indicators of vulnerability, which may lead to improved early identification of individuals at risk for schizophrenia. ..
  32. Functional Organization of Cardiovascular Reactivity
    Peter Gianaros; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. Behavioral correlates of fMRI response in cocaine users
    Rita Goldstein; Fiscal Year: 2006
    ..abstract_text> ..
  34. Magnetic Resonance Spectroscopy in Affective Illness
    CONSTANCE MOORE; Fiscal Year: 2005
    ..Decreased caudate nucleus beta-NTP will be associated with depression. An increase in caudate nucleus PME will occur as a result of lithium treatment. ..
  35. Synaptic change in cingulate cortex after amputation
    Min Zhuo; Fiscal Year: 2006
    ..This information will provide a potential neuronal basis for understanding phantom limb sensation and phantom pain. ..
  36. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..
  37. SEROTONERGIC REGULATION OF SENSORY TRANSMISSION
    Min Zhuo; Fiscal Year: 2002
    ..The proposed studies will generate synaptic mechanisms for fast glutamatergic transmission as well as 5-HT regulation in the spinal cord. This information will be important for understanding central pain transmission and modulation. ..
  38. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..We propose to use laser micro-dissection to investigate gene expression in specific neuronal and non-neuronal populations in the cortical areas of interest in the autism-A, autism-B and control groups. ..
  39. Neural Substrates of Emotion in Borderline Patients
    Erin Hazlett; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  40. FMRI CINGULATE DISSECTION IN CINGULOTOMY PATIENTS & ADHD
    ALLAN BUSH; Fiscal Year: 2002
    ....
  41. THE NEURAL CIRCUITRY OF SENSORIMOTOR GATING
    Erin Hazlett; Fiscal Year: 2002
    ....
  42. NEURAL MECHANISMS OF SIZE PERCEPTION
    John Allman; Fiscal Year: 2001
    ..Finally, we will map the extent of the surrounding non-CRF by masking parts of the visual contextual display while measuring the responses to different sized stimuli presented within the CRF. ..
  43. PREVENTION OF GERATRIC DEPRESSION
    George Alexopoulos; Fiscal Year: 2003
    ..Accordingly, we are well positioned to meet the challenges inherent in this difficult but important area of research. ..
  44. Frontal Neural Mechanisms and Risk for Substance Abuse
    Staci Gruber; Fiscal Year: 2003
    ..Additionally, findings from this project will provide the foundation for future grant applications aimed at examining the role of the prefrontal cortex in substance abuse. ..
  45. Dysfunctional Cortico-Limbic Activity and Connectivity in Bipolar Disorder and Li
    Amit Anand; Fiscal Year: 2010
    ..This study will also establish an experimental paradigm to study brain connectivity which could be used to investigate other disorders. ..
  46. PREVENTION OF SUICIDE IN THE ELDERLY
    George Alexopoulos; Fiscal Year: 2002
    ..Data will also be collected to document the impact of intervention on patient care, and on physician knowledge, attitudes, and satisfaction and test hypotheses derived from preliminary studies of the three IRCs. ..
  47. Treatment Effectiveness in Depressed Patients with COPD
    George Alexopoulos; Fiscal Year: 2006
    ..Finally, we believe that our approach to the care of depressed, medically ill patients can generate a practice model that has the ability to rapidly incorporate advances made in clinical science. ..
  48. Neuroimaging and Functional Senscence in Aging
    Nikolaos Makris; Fiscal Year: 2002
    ..abstract_text> ..
  49. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  50. Marijuana and Mood: Frontal Predictors of Behavior
    Staci Gruber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. FMRI/Pathology/Anterior Cingulate/Frontoinsular Cortex
    WILLIAM SEELEY; Fiscal Year: 2007
    ..The proposed research seeks to benefit the public health by clarifying the biological basis of dementia, ultimately promoting earlier diagnosis and better treatments for dementia patients. ..
  52. Reward System Recovery Following Behavioral Activation Therapy in Depression
    GABRIEL DICHTER; Fiscal Year: 2007
    ..Such a strategy is consistent with NIMH's mission to reduce the burden of psychiatric disorders. [unreadable] [unreadable] [unreadable]..
  53. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Brain Chemistry and Treatment Response in Pediatric MDD
    David Rosenberg; Fiscal Year: 2005
    ..An understanding of the neurochemical disturbances in MDD may be important for the development of new treatment approaches. ..
  55. Divalproex sodium and Risperidone in Pediatric Bipolar Disorder
    Mani Pavuluri; Fiscal Year: 2007
    ..During five years, 40 outpatient subjects with PBD manic or mixed episodes, ages 8-17 years, referred to the UI Pediatric Mood Disorder Clinic will be recruited. ..
  56. Neural Substrates of Executive Control Revealed by FMRI
    Daniel Weissman; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. fMRI of Pain in Cannabis Dependence
    SRINIVASAN PILLAY; Fiscal Year: 2004
    ....
  58. FUNCTIONAL MRI OF HUMAN BRAIN LANGUAGE SYSTEMS
    Jeffrey R Binder; Fiscal Year: 2010
    ..abstract_text> ..
  59. Cornell ACISR for Late Life Depression
    George Alexopoulos; Fiscal Year: 2007
    ..We are confident that our work will both advance scientific knowledge and have a broad impact on the care of depressed, disabled elders. ..
  60. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton D Kilts; Fiscal Year: 2010
    ....
  61. LONG QT SYNDROME:EMOTIONAL TRIGGERS OF CARDIAC EVENTS
    Richard Lane; Fiscal Year: 2005
    ..abstract_text> ..
  62. Neuroanatomy of Anticipation in Anxiety Disorders
    Jack Nitschke; Fiscal Year: 2009
    ..g., anticipation that results in adaptive response) as well as understanding how dysfunction in this system occurs. ..
  63. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
    ..Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders. ..