respiratory center

Summary

Top Publications

  1. ncbi Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo
    Muriel Thoby-Brisson
    Laboratoire de Neurobiologie Génétique et Intégrative, Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Neurosci 25:4307-18. 2005
  2. ncbi Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3806-16. 2002
  3. ncbi Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models
    D W Richter
    Dept of Physiology II, Georg August Universitat Gottingen, 37073, Gottingen, Germany
    Trends Neurosci 24:464-72. 2001
  4. ncbi Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors
    Andrew K Tryba
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 26:2623-34. 2006
  5. ncbi Respiratory rhythm entrainment by somatic afferent stimulation
    Jeffrey T Potts
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 25:1965-78. 2005
  6. pmc Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse
    Consuelo Morgado-Valle
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 30:3634-9. 2010
  7. ncbi Ontogeny of the pre-Bötzinger complex in perinatal rats
    Silvia Pagliardini
    Department of Physiology, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 23:9575-84. 2003
  8. ncbi Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:7549-56. 2004
  9. ncbi Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    J Appl Physiol 100:2094-5. 2006
  10. ncbi Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    Neuron 43:105-17. 2004

Detail Information

Publications213 found, 100 shown here

  1. ncbi Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo
    Muriel Thoby-Brisson
    Laboratoire de Neurobiologie Génétique et Intégrative, Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    J Neurosci 25:4307-18. 2005
    ..We conclude that a rhythm generator sharing the properties of the neonatal pre-Bötzinger complex becomes active during E15 in mice...
  2. ncbi Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3806-16. 2002
    ..In summary, NK1R-expressing cells of the VRG are a heterogeneous group of predominantly glutamatergic neurons that include subpopulations of respiratory premotor neurons...
  3. ncbi Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models
    D W Richter
    Dept of Physiology II, Georg August Universitat Gottingen, 37073, Gottingen, Germany
    Trends Neurosci 24:464-72. 2001
    ..We have taken note of these in formulating a 'maturational network-burster model' for rhythm generation that includes most features of the existing models of respiratory rhythm generation...
  4. ncbi Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors
    Andrew K Tryba
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 26:2623-34. 2006
    ..These data support the hypothesis that two types of pacemaker bursting mechanisms underlie fictive eupnea, whereas only one burst mechanism is critical for gasping...
  5. ncbi Respiratory rhythm entrainment by somatic afferent stimulation
    Jeffrey T Potts
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 25:1965-78. 2005
    ....
  6. pmc Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse
    Consuelo Morgado-Valle
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 30:3634-9. 2010
    ..Testable and nontrivial predictions of the functional role of excitatory and inhibitory pacemaker neurons need to be proposed and the necessary experiments performed...
  7. ncbi Ontogeny of the pre-Bötzinger complex in perinatal rats
    Silvia Pagliardini
    Department of Physiology, Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 23:9575-84. 2003
    ....
  8. ncbi Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 24:7549-56. 2004
    ..This finding may have clinical implications for Rett syndrome in which SP levels along with other neuromodulators are decreased in the brainstem...
  9. ncbi Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Point: the PFRG is the primary site of respiratory rhythm generation in the mammal
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    J Appl Physiol 100:2094-5. 2006
  10. ncbi Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia
    Fernando Pena
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    Neuron 43:105-17. 2004
    ..We propose that respiratory rhythm generation in normoxia depends on a heterogeneous population of pacemaker neurons, while during hypoxia the respiratory rhythm is driven by only one type of pacemaker...
  11. ncbi Stabilization of bursting in respiratory pacemaker neurons
    Andrew K Tryba
    The University of Chicago, Department of Organismal Biology and Anatomy, Chicago, Illinois 60637, USA
    J Neurosci 23:3538-46. 2003
    ..001; n = 14). We conclude that respiratory pacemaker neurons possess membrane properties that stabilize their bursting against changes in [K+]o and imposed changes in V(m)...
  12. pmc Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro
    Jean Charles Viemari
    Laboratoire Plasticité et Physio Pathologie de la Motricité, CNRS UMR 6196, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Eur J Neurosci 33:2228-37. 2011
    ..Our data suggest that gasping depends on the converging aminergic activation of 5-HT2AR and α2-NR acting on riluzole-sensitive mechanisms that have been shown to be crucial for gasping...
  13. ncbi Regulation of ventral surface chemoreceptors by the central respiratory pattern generator
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 25:8938-47. 2005
    ..In vivo, RTN neurons receive respiratory synchronous inhibitory inputs that may serve as feedback and impart these neurons with their characteristic respiratory modulation...
  14. ncbi Pre-/post-otic rhombomeric interactions control the emergence of a fetal-like respiratory rhythm in the mouse embryo
    C Borday
    Neurobiologie Genetique et Integrative, Institut de Neurobiologie Alfred Fessard, C N R S, 1 Av de la Terrasse, 91198 Gif sur Yvette, France
    J Neurobiol 66:1285-301. 2006
    ....
  15. ncbi Generation of a novel functional neuronal circuit in Hoxa1 mutant mice
    E D del Toro
    Neurobiologie Genetique et Integrative, Unité Propre de Recherche 2216, Centre National de la Recherche Scientifique CNRS, 91198 Gif sur Yvette, France
    J Neurosci 21:5637-42. 2001
    ..This is the first demonstration that changes in Hox expression patterns allow the selection of novel neuronal circuits regulating vital adaptive behaviors. The implications for the evolution of brainstem neural networks are discussed...
  16. pmc Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:519-28. 2008
    ..Furthermore, functional alpha4* nAChRs are present in XII nucleus and mediate cholinergic/nicotinic modulation of tonic activity in XIIn...
  17. ncbi Mechanisms underlying regulation of respiratory pattern by nicotine in preBötzinger complex
    X M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 85:2461-7. 2001
    ..These mechanisms may account for the cholinergic regulation of respiratory frequency and pattern...
  18. ncbi Cholinergic neurotransmission in the preBötzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm
    X M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    Neuroscience 130:1069-81. 2005
    ....
  19. ncbi Possible modulation of the mouse respiratory rhythm generator by A1/C1 neurones
    Sebastien Zanella
    FRE CNRS 2722, Universite de la Mediterranee, 280 Boulevard Sainte Marguerite, 13009 Marseille, France
    Respir Physiol Neurobiol 153:126-38. 2006
    ....
  20. ncbi Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern
    Xuesi M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 88:1851-8. 2002
    ..This study provides a useful model system for evaluating potential therapeutic cholinergic agents for their respiratory effects and side effects...
  21. pmc Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat
    Wenbin Tan
    Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E Young Dr South, Los Angeles, California 90095, USA
    Nat Neurosci 11:538-40. 2008
    ..We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure...
  22. ncbi Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat
    Irene C Solomon
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    J Neurophysiol 89:135-49. 2003
    ....
  23. pmc Looking for inspiration: new perspectives on respiratory rhythm
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Box 951763, Los Angeles, California 90095 1763, USA
    Nat Rev Neurosci 7:232-42. 2006
    ..Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing...
  24. ncbi Association of nicotinic acetylcholine receptors with central respiratory control in isolated brainstem-spinal cord preparation of neonatal rats
    Eiki Hatori
    Department of Anesthesiology, School of Medicine, Keio University, Tokyo, Japan
    Biol Res 39:321-30. 2006
    ..These findings indicate that alpha4beta2 nAChR is involved in both inspiratory and preinspiratory neurons, whereas alpha7 nAChR functions only in preinspiratory neurons to modulate C4 respiratory rate...
  25. ncbi Generation of eupnea and sighs by a spatiochemically organized inspiratory network
    Araya Ruangkittisakul
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 28:2447-58. 2008
    ....
  26. pmc Prenatal nicotine exposure increases the strength of GABA(A) receptor-mediated inhibition of respiratory rhythm in neonatal rats
    Zili Luo
    Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85721, USA
    J Physiol 561:387-93. 2004
    ..The results may lead to a better understanding of the perturbed breathing pattern observed in neonates that are exposed to nicotine in utero...
  27. pmc Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 582:113-25. 2007
    ..We conclude that I(CAN) underlies robust inspiratory drive potentials in preBötC neurons, and is only fully evoked by ionotropic and metabotropic glutamatergic synaptic inputs, i.e. by network activity...
  28. pmc Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 160:353-6. 2008
    ..However, gasping does depend upon a conductance through persistent sodium channels...
  29. ncbi Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Appl Physiol 100:2096-7; discussion 2097-8, 2103-8. 2006
  30. ncbi Respiration-related rhythmic activity in the rostral medulla of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Neurophysiol 96:55-61. 2006
    ..These results show that the rostral medulla, not including the pre-Bötzinger complex, produces Pre-I-like rhythmic activity that can be monitored as facial nerve motor output in newborn rat in vitro preparations...
  31. pmc Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness
    Mirela Barros Dias
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    J Physiol 587:2059-67. 2009
    ..We conclude that projections of orexin-containing neurons to the RTN contribute, via OX(1)Rs in the region, to the hypercapnic chemoreflex control during wakefulness and to a lesser extent, non-rapid eye movement sleep...
  32. ncbi Respiratory control by ventral surface chemoreceptor neurons in rats
    Daniel K Mulkey
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Neurosci 7:1360-9. 2004
    ..Their pH sensitivity is intrinsic and involves a background K(+) current. In short, the CO(2)-sensitive neurons of the RTN are good candidates for the long sought-after VMS chemoreceptors...
  33. pmc Glutamatergic synaptic inputs and ICAN: the basis for an emergent property underlying respiratory rhythm generation?
    STEPHEN MARK JOHNSON
    Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, Madison, WI 53706, USA
    J Physiol 582:5-6. 2007
  34. ncbi Respiratory and metabolic acidosis differentially affect the respiratory neuronal network in the ventral medulla of neonatal rats
    Yasumasa Okada
    Department of Medicine, Keio University Tsukigase Rehabilitation Center, Izu, Japan
    Eur J Neurosci 26:2834-43. 2007
    ..We suggest that they differently influence the coupling states between the pFRG/RTN and preBötC/VRG...
  35. ncbi Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro
    Christopher A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4455, USA
    J Neurophysiol 88:2242-50. 2002
    ....
  36. ncbi High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices
    Araya Ruangkittisakul
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 26:11870-80. 2006
    ..Our approaches and findings provide the basis for a pharmacological and structure-function analysis of the isolated respiratory center in a histologically well defined substrate at physiological [K+].
  37. pmc Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis
    Steffen Wittmeier
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:18000-5. 2008
    ..Such a pacemakers handshake process with conjugate excitation-inhibition and PIR provides a reinforcing and evolutionarily advantageous fail-safe mechanism for respiratory rhythmogenesis in mammals...
  38. ncbi Respiratory network function in the isolated brainstem-spinal cord of newborn rats
    K Ballanyi
    II Physiologisches Institut, Universitat Gottingen, Germany
    Prog Neurobiol 59:583-634. 1999
    ..The latter observations show that this in vitro model is also suited for analysis of clinically relevant disturbances of respiratory network function...
  39. ncbi Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro
    Hidehiko Koizumi
    Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:2353-65. 2008
    ....
  40. ncbi Determinants of inspiratory activity
    Jan Marino Ramirez
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 147:145-57. 2005
    ....
  41. ncbi Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 25:446-53. 2005
    ..When I(NaP) and I(CAN) are removed pharmacologically, the rhythm can be maintained by boosting neural excitability, which is inconsistent with a pacemaker-essential mechanism of respiratory rhythmogenesis by the preBotzinger complex...
  42. ncbi Respiratory rhythm generation during gasping depends on persistent sodium current
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK
    Nat Neurosci 9:311-3. 2006
    ..We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism...
  43. ncbi Hypoxic modulation of L-type Ca(2+) channels in inspiratory brainstem neurones: intracellular signalling pathways and metabotropic glutamate receptors
    S L Mironov
    II Department of Physiology, University of Gottingen, Humboldtallee 23, D 37073, Gottingen, Germany
    Brain Res 869:166-77. 2000
    ..agonists suppressed the respiratory output, and correspondingly modified the hypoxic response of the respiratory center. Ca(L) channels were also modulated by protein kinase C, but this did not prevent the hypoxic modification ..
  44. ncbi Hyperpolarization-activated current, Ih, in inspiratory brainstem neurons and its inhibition by hypoxia
    S L Mironov
    II Department of Physiology, University of Gottingen, Humboldtallee 23, Gottingen 37073, Germany
    Eur J Neurosci 12:520-6. 2000
    ..We conclude that although Ih channels are functional in a minority of inspiratory neurons, Ih does not contribute to respiratory rhythm generation or its modulation by hypoxia...
  45. ncbi RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Bötzinger complex
    J Lai
    Department of Neurobiology, University of California, Los Angeles, California 90095-1763, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1420-4. 2001
    ..All five subtypes, M(1)-M(5), were observed in the second round of amplification. Our results suggest that the majority of muscarinic receptor subtypes in the pre-BötC are M(2) and M(3), with minor expression of M(1), M(4), and M(5)...
  46. ncbi Identification of two types of inspiratory pacemaker neurons in the isolated respiratory neural network of mice
    M Thoby-Brisson
    Department of Organismal Biology and Anatomy, Committee on Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurophysiol 86:104-12. 2001
    ..5 microM tetrodotoxin. We conclude that the respiratory neural network contains pacemaker neurons with two types of bursting properties. The two types of pacemaker activities might have different functions within the respiratory network...
  47. ncbi Different respiratory control systems are affected in homozygous and heterozygous kreisler mutant mice
    Fabrice Chatonnet
    Neurobiologie Genetique et Integrative, UPR2216, Centre National de la Recherche Scientifique, Institut de Neurobiologie Alfred Fessard UFR 2218, 91198 Gif sur Yvette Cedex, France
    Eur J Neurosci 15:684-92. 2002
    ..We conclude that the pontine antiapneic system originates from r3r4, but not r5. A different rhythm-promoting system originates in r5 and kreisler controls the development of antiapneic and chemosensory signal transmission at this level...
  48. ncbi Phox2a gene, A6 neurons, and noradrenaline are essential for development of normal respiratory rhythm in mice
    J C Viemari
    Biology of Rhythms and Development, Groupe d Etude des Réseaux Moteurs Centre National de la Recherche Scientifique, 13009 Marseille, France
    J Neurosci 24:928-37. 2004
    ..Metabolic noradrenaline disorders occurring during gestation therefore may induce neonatal respiratory deficits, in agreement with the catecholamine anomalies reported in victims of sudden infant death syndrome...
  49. ncbi From hindbrain segmentation to breathing after birth: developmental patterning in rhombomeres 3 and 4
    Fabrice Chatonnet
    UPR 2216 Neurobiologie Génétique et Intégrative, Institut de Neurobiologie Alfred Fessard, CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Mol Neurobiol 28:277-94. 2003
    ..Novel neuronal circuits may develop from some of these misspecified progenitors while others are eliminated, eventually affecting respiration and survival after birth...
  50. ncbi Role of gap junctions in CO(2) chemoreception and respiratory control
    Jay B Dean
    Department of Physiology and Biophysics, Environmental and Hyperbaric Cell Biology Facility, Wright State University, Dayton, Ohio 45435, USA
    Am J Physiol Lung Cell Mol Physiol 283:L665-70. 2002
    ..Specific research questions related to the role of gap junctions in respiratory control are suggested for future research...
  51. pmc Brain-derived neurotrophic factor enhances fetal respiratory rhythm frequency in the mouse preBötzinger complex in vitro
    Julien Bouvier
    Laboratoire de Neurobiologie Génétique et Intégrative, Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Eur J Neurosci 28:510-20. 2008
    ..Our data indicate that BDNF signalling through TrkB can acutely modulate fetal respiratory rhythm in association with increased glutamatergic drive and bursting activity in the preBötC...
  52. pmc Inspiratory-phase short time scale synchrony in the brainstem slice is generated downstream of the pre-Bötzinger complex
    J Y Sebe
    Graduate Program in Neurobiology and Behavior, Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Neuroscience 153:1390-401. 2008
    ....
  53. ncbi Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats
    Shigeki Sakuraba
    Department of Anesthesiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biol Res 38:225-33. 2005
    ..Our results demonstrate that neuromuscular blocking agents inhibit CO2-excited tonic firing neurons and attenuate respiratory CO2 responsiveness...
  54. ncbi Ionotropic glutamate receptors mediate excitatory drive to caudal medullary expiratory neurons in the rabbit
    Fulvia Bongianni
    Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale G B Morgagni 63, I 50134 Firenze, Italy
    Brain Res 1056:145-57. 2005
    ..They also support the view that neurons located in the cVRG are not merely elements of the expiratory output system...
  55. ncbi [Reaction of respiration neurons in the medulla on locus coeruleus irritation by hypoxia]
    N S Akopian
    Aviakosm Ekolog Med 42:36-40. 2008
    ..event of acute hypoxia the highly sensitive cortical component lose their inhibitory effect on the bulbar respiratory center and suprabulbary formations...
  56. ncbi Central nervous mechanisms in the generation of the pattern of breathing
    T Pantaleo
    Dipartimento di Scienze Fisiologiche, Universita di Firenze, Viale G B Morgagni 63, I 50134 Firenze, Italy
    Arch Ital Biol 143:207-14. 2005
    ..The results show that the investigated medullary regions play a prominent role in the genesis of the normal pattern of breathing through the endogenous activation of EAA receptors...
  57. ncbi Responses of respiratory neurons in the medulla oblongata to stimulation of the septal nuclei during hypoxia
    N S Akopyan
    Department of Human and Animal Physiology, Armenian State University, 8 Charenets Street, 375049 Erevan, Armenia
    Neurosci Behav Physiol 34:105-8. 2004
    ..pressure had both facilitatory and inhibitory effects on the spike activity of respiratory neurons in the respiratory center of the medulla oblongata, inhibitory effects being predominant...
  58. ncbi Spontaneous crossed phrenic activity in the neonatal respiratory network
    M Beth Zimmer
    Wayne State University, School of Medicine, Department of Anatomy and Cell Biology, 540 East Canfield, Detroit, MI 48201, USA
    Exp Neurol 194:530-40. 2005
    ..Unlike adult rats, this study shows that crossed phrenic activity is present in the in vitro respiratory network of neonatal rats suggesting that a crossed neural pathway may be functionally active in neonates...
  59. ncbi Background sodium current stabilizes bursting in respiratory pacemaker neurons
    Andrew K Tryba
    The University of Chicago, Department of Organismal Biology, 1027 E 57th Street, Chicago, Illinois 60637, USA
    J Neurobiol 60:481-9. 2004
    ..Thus, current-clamp studies suggest that respiratory pacemaker neurons possess a background sodium current that maintains their membrane potential within a range where they express bursting, thereby stabilizing rhythmogenesis...
  60. ncbi [Effects of enflurane on respiratory neurons of the pre-Bötzinger complex in medullary slices of neonatal rats]
    Y Yamazaki
    Department of Anesthesiology, Sapporo Medical University, School of Medicine, Sapporo 060-8543
    Masui 50:964-70. 2001
    ..These results suggest that the enflurane-induced decrement of spontaneous activity of respiratory neurons is partly caused by an increase in synaptic inhibition...
  61. ncbi Modulation of the respiratory rhythm generator by the pontine noradrenergic A5 and A6 groups in rodents
    Gerard Hilaire
    GERM Groupe d Etude des Réseaux Moteurs, FRE CNRS 2722, 280 Boulevard Sainte Marguerite, 13009 Marseille, France
    Respir Physiol Neurobiol 143:187-97. 2004
    ....
  62. ncbi [Effect of stimulation of the facial nucleus on discharge of respiratory neurons in the pre-Bözinger complex and its neurotransmitter mechanism in rats]
    Heng Xiu Yan
    Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sheng Li Xue Bao 56:665-70. 2004
    ....
  63. pmc Connections between respiratory neurones in the neonatal rat transverse medullary slice studied with cross-correlation
    Yan Mei Li
    Department of Physiology, University of Toronto, ON, Canada
    J Physiol 549:327-32. 2003
    ..The rhythm is transmitted to ipsilateral hypoglossal neurones by a paucisynaptic pathway. Both hypoglossal neurones and PBC neurones receive a common activation from as yet unidentified sources...
  64. ncbi Calcium-activated potassium currents differentially modulate respiratory rhythm generation
    C Zavala-Tecuapetla
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados del I P N, Mexico, DF, Mexico
    Eur J Neurosci 27:2871-84. 2008
    ....
  65. ncbi [Response of respiratory neurons of the medulla oblongata to the septum stimulation in hypoxia]
    N S Akopian
    State University, Yerevan, 375049, 8 Charentsa St, Armenia
    Ross Fiziol Zh Im I M Sechenova 88:997-1002. 2002
    ..In difficult conditions of hypoxia (7.5-8 thousand meters) on the reduction of the impulse activity of neurons, stimulation of septum nucleuses induced uncharacteristic reactions of those neurons...
  66. ncbi Glutamatergic neurons in the Kölliker-Fuse nucleus project to the rostral ventral respiratory group and phrenic nucleus: a combined retrograde tracing and in situ hybridization study in the rat
    Shigefumi Yokota
    Department of Anatomy and Morphological Neuroscience, Shimane University School of Medicine, Izumo 693 8501, Japan
    Neurosci Res 59:341-6. 2007
    ....
  67. ncbi Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Jaime L Eugenín
    J Appl Physiol 103:724; author reply 726-7. 2007
  68. ncbi Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Fernando Pena
    J Appl Physiol 103:723-4; author reply 726-7. 2007
  69. ncbi Respiratory rhythms generated in the lamprey rhombencephalon
    B Martel
    Centre de Recherche en Sciences Neurologiques, Universite de Montreal, Casier Postal 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Neuroscience 148:279-93. 2007
    ..Our results support the hypothesis that normal breathing depends on the activity of neurons located in the rostral rhombencephalon in lampreys, whereas the caudal rhombencephalon generates the slow pattern...
  70. ncbi Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms
    M Beth Zimmer
    Wayne State University, Department of Anatomy and Cell Biology, Detroit, MI 48201, USA
    Exp Neurol 206:137-45. 2007
    ..These data show that supraspinal plasticity in the respiratory system occurs after SCI in neonate rats. The mechanisms remain unknown, but may involve alterations in receptor proteins involved in neurotransmission...
  71. ncbi Multifunctional laryngeal premotor neurons: their activities during breathing, coughing, sneezing, and swallowing
    Keisuke Shiba
    Department of Otolaryngology, Graduate School of Medicine, Chiba University, Chiba City, Chiba 260 8670, Japan
    J Neurosci 27:5156-62. 2007
    ....
  72. pmc NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors
    Consuelo Morgado-Valle
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Box 951763, Los Angeles, CA 90095 1763, USA
    J Physiol 582:359-68. 2007
    ..Under this condition, respiratory-related frequency is unaffected by changes in I(I), suggesting that the two can be independently regulated...
  73. ncbi [Development of respiratory function in perinatal ontogenesis]
    A V Bursian
    Zh Evol Biokhim Fiziol 43:24-31. 2007
    ..Somewhat later, inhibitory control is established from supramedullary structures, with an increase of role of peripheral receptors in regulation of respiration...
  74. pmc Regulation of respiratory and vocal motor pools in the isolated brain of Xenopus laevis
    Erik Zornik
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 28:612-21. 2008
    ..Together, our data suggest that neurons in DTAM produce vocal motor output by directly activating laryngeal motor neurons and that DTAM may coordinate vocal and respiratory motor activity...
  75. ncbi Respiratory neuron subpopulations and pathways potentially involved in the reactivation of phrenic motoneurons after C2 hemisection
    Pascale Boulenguez
    Laboratoire de Physiologie Neurovégétative, UMR CNRS 6153, INRA 1147, Universite Paul Cezanne, Aix Marseille III, Marseille, France
    Brain Res 1148:96-104. 2007
    ..These pathways may be involved in the CPP and could be differentially activated in acute or chronic lesioned rats...
  76. ncbi [Effects of pentobarbital sodium on rhythmical respiration of neonatal rat medullary preparations]
    Juan Chen
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1273-5, 1279. 2006
    ..To study the effects of pentobarbital sodium in generation and modulation of rhythmical respiration in neonatal rats...
  77. ncbi Adrenaline contributes to prenatal respiratory maturation in rat medulla-spinal cord preparation
    Morimitsu Fujii
    Laboratory for Memory and Learning, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Brain Res 1090:45-50. 2006
    Adrenaline is a potent respiratory regulator. However, adrenergic contribution to the developing respiratory center has not been studied extensively...
  78. ncbi Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats"
    Wiktor A Janczewski
    J Neurophysiol 96:1-2. 2006
  79. pmc The retrotrapezoid nucleus and the 'drive' to breathe
    Eugene E Nattie
    Department of Physiology, Darthmouth Medical School, Lebanon, NH 03755, USA
    J Physiol 572:311. 2006
  80. pmc Anoxic persistence of lumbar respiratory bursts and block of lumbar locomotion in newborn rat brainstem spinal cords
    Giuliano Taccola
    Perinatal Research Centre, Department of Physiology, University of Alberta, Edmonton, AB, Canada T6G 2S2
    J Physiol 585:507-24. 2007
    ....
  81. ncbi Evidence for a tonic GABA-ergic inhibition of excitatory respiratory-related afferents to presympathetic neurons in the rostral ventrolateral medulla
    Takashi Miyawaki
    Hypertension and Stroke Research Laboratories, Department of Physiology, University of Sydney, Sydney 2006, Australia
    Brain Res 924:56-62. 2002
    ..Inputs from post-inspiratory neurons appear to be an especially potent excitatory synaptic drive to the presympathetic neurons in the absence of the GABAergic inhibition...
  82. ncbi Presynaptic delta opioid receptors differentially modulate rhythm and pattern generation in the ventral respiratory group of the rat
    T Lonergan
    Department of Pharmacology, University of Sydney, Camperdown, New South Wales, 2006, Australia
    Neuroscience 121:959-73. 2003
    ..Activation of the DOR in the VRG is likely to inhibit the release of neurotransmitters from afferent inputs that modulate the pattern of activity of VRG neurons...
  83. ncbi Noradrenergic receptors and in vitro respiratory rhythm: possible interspecies differences between mouse and rat neonates
    Viemari Jean-Charles
    Groupe d Etudes des Réseaux Moteurs, Biology of Rhythms and Development, GERM, CNRS, Universite de la Mediterranee, 280 Boulevard de Sainte Marguerite, 13009 Marseille, France
    Neurosci Lett 324:149-53. 2002
    ..Thus, interspecies differences seem to exist in the noradrenergic regulations of the rat and mouse medullary respiratory networks...
  84. ncbi Respiratory pre-motor control of hypoglossal motoneurons in the rat
    J H Peever
    Department of Physiology, University of Toronto, Ontario, Canada
    Neuroscience 110:711-22. 2002
    ..We conclude that the respiratory control of hypoglossal motoneurons originates from inspiratory premotor neurons scattered throughout the lateral tegmental field and interneurons within the hypoglossal motor nucleus...
  85. ncbi The respiratory rhythm in mutant oscillator mice
    D Büsselberg
    Georg August Universitat Gottingen, II Physiologisches Institut, Humboldtallee 23, D 37073 Gottingen, Germany
    Neurosci Lett 316:99-102. 2001
    ..Postsynaptic activity and membrane potential trajectories of respiratory neurones revealed a persistence of GABAergic inhibition and changes in respiratory rhythm and pattern generation...
  86. ncbi Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of perinatal rats
    S W Schwarzacher
    Zentrum Anatomie, Universitat Gottingen, Kreuzbergring 36, D 37075, Gottingen, Germany
    Neuroscience 115:1247-59. 2002
    ..The excitatory effects on respiratory rhythm are also primarily attributable to postsynaptic 5-HT2 receptors of pre-BötC neurons. Additional modulatory effects on the interneurons appear to be mediated by postsynaptic 5-HT1A receptors...
  87. ncbi The murine neurokinin NK1 receptor gene contributes to the adult hypoxic facilitation of ventilation
    Krzysztof Ptak
    Physiologie Neurovégétative, UMR 6153 CNRS INRA, Faculté des Sciences de St Jérôme, 13397 Marseille Cedex 20, France
    Eur J Neurosci 16:2245-52. 2002
    ..However, NK1 receptors are not obligatory for the prenatal development of the respiratory network, for the production of the rhythm, or for the regulation of breathing by short-lasting hypoxia in neonates...
  88. ncbi Effect of endothelin on vasomotor and respiratory neurons in the rostral ventrolateral medulla in rats
    Mamoru Kumada
    Department of Physiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cell Mol Neurobiol 23:691-707. 2003
    ..Majority of vasomotor and respiratory neurons should express ET-A receptors and some respiratory neurons are under tonic excitatory control by ET-1...
  89. ncbi MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth
    Bruno Blanchi
    Centre d immunologie de Marseille Luminy, CNRS INSERM Université Mediterrané, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Nat Neurosci 6:1091-100. 2003
    ..Our results show an essential role of MafB in central respiratory control, possibly involving the specification of rhythmogenic preBötC neurons...
  90. ncbi Neurokinin-1 receptor-expressing cells regulate depressor region of rat ventrolateral medulla
    Hong Wang
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 285:H2757-69. 2003
    ....
  91. ncbi Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Eur J Neurosci 18:239-57. 2003
    ..These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping...
  92. ncbi Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances
    Peter M Lalley
    Department of Physiology, The University of Wisconsin, Madison, Wisconsin 53706m, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1287-304. 2003
    ..Opioid effects on the respiratory neurons were similar in anesthetized and decerebrate preparations...
  93. ncbi Two types of rhythm in the respiratory network output in the isolated ventrolateral medulla in the neonatal rats
    Y N Shvarev
    Department of Woman and Child Health, Q2 07, Neonatal Research Unit, Astrid Lindgren Children s Hospital, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Neurosci Lett 347:53-6. 2003
    ..The augmented bursts could suppress inspiratory, but not pre-inspiratory neuron discharge, suggesting that pre-inspiratory neurons formed a supplementary rhythmic network which was not directly affected by biphasic burst generation...
  94. ncbi Morphology of the decrementing expiratory neurons in the brainstem of the rat
    Yoshiaki Saito
    Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashi dai, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 44:141-53. 2002
    ..The simultaneous projections from the caudal E-DEC neurons to both the spinal cord and the NA suggest that these neurons also play integrative roles in non-respiratory behaviors including vocalization, swallowing and defecation...
  95. ncbi Respiratory rhythm: an emergent network property?
    Christopher A Del Negro
    Systems Neurobiology Laboratory, Department of Neurobiology, University of California Los Angeles, Box 95 1763, 90095, USA
    Neuron 34:821-30. 2002
    ..05) does not affect respiratory rhythm. These results suggest that voltage-dependent bursting in pacemaker neurons is not essential for respiratory rhythmogenesis, which may instead be an emergent network property...
  96. ncbi Glutamatergic pathways from the Kölliker-Fuse nucleus to the phrenic nucleus in the rat
    Shigefumi Yokota
    Department of Anatomy and Morphological Neuroscience, Shimane Medical University, Izumo 693 8501, Japan
    Brain Res 995:118-30. 2004
    ..The present results suggest that the glutamatergic pathways from the KF to the PhN directly and indirectly via the rVRG region may exist and underlie the inspiratory responses that are elicited by activation of the KF neurons...
  97. ncbi Inspiratory neurons with decrementing firing pattern in raphe nuclei of feline medulla
    Masae Hosogai
    Second Department of Physiology, Faculty of Medicine, Tottori University, Yonago, Japan
    Auton Neurosci 99:13-7. 2002
    ..The present results suggest that cat I-decrementing neurons in the medullary raphe nuclei receive inputs from the central respiratory rhythm generator and may modify the respiratory activity of supraspinal neural structures...
  98. ncbi Glycine is used as a transmitter by decrementing expiratory neurons of the ventrolateral medulla in the rat
    Kazuhisa Ezure
    Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    J Neurosci 23:8941-8. 2003
    ....
  99. pmc Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat
    M Dutschmann
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 543:643-53. 2002
    ....
  100. ncbi Role of NO-ergic mechanism in regulation of rhythmogenesis in respiratory center in bulbospinal preparation from newborn rat
    V F Pyatin
    Samara State Medical University, Samara
    Bull Exp Biol Med 132:719-22. 2001
    ....
  101. ncbi Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds
    Milan Jokanovic
    Experta Consulting, 11070 Belgrade, Nehruova 57, Serbia
    Curr Med Chem 16:2177-88. 2009
    ..failure resulting from paralysis of the diaphragm and intercostal muscles, depression of the brain respiratory center, bronchospasm, and excessive bronchial secretions...

Research Grants48

  1. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..This longitudinal study of asthma and allergy, conducted at the Arizona Respiratory Center, University of Arizona, enrolled at birth a large population of healthy children and is still following them ..
  2. Role of Central 5-HT Transmission in Respiratory Arrest Induced by Seizures
    Huajun Feng; Fiscal Year: 2013
    ..We hypothesize that insufficient 5-HT neurotransmission in medullary respiratory center causes respiratory arrest evoked by generalized seizures in DBA/1 mice...
  3. Arizona/Duke Clinical Center for AsthmaNet
    Fernando D Martinez; Fiscal Year: 2013
    ..This proposal is leveraged on the complementary strengths on the Duke Asthma Center and the Arizona Respiratory Center in the areas of severe adult asthma and childhood asthma, respectively...
  4. Role of vagal nerves in hyperpnea
    Jerry Yu; Fiscal Year: 2006
    ..There are several types of nerve endings in the lung, which provide the respiratory center with information about mechanical and chemical changes...
  5. VAGAL NERVES AND HYPERPNEA
    Jerry Yu; Fiscal Year: 2001
    ..There are several types of nerve endings in the lung, which provide the respiratory center with information about mechanical and chemical changes...
  6. CARDIOPULMONARY FUNCTION OF METHADONE EXPOSED INFANTS
    Martin Lees; Fiscal Year: 1980
    We are examining chemoreceptor function, respiratory center output and cardiac rate reactivity in two groups of infants believed at high risk of sudden infant death syndrome (SIDS)...
  7. Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Morality
    Stefano Guerra; Fiscal Year: 2007
    ..establishment of a collaborative project between the molecular and genetic epidemiology core of the Arizona Respiratory Center and the Proteomics Analysis Laboratory at the University of Arizona and, in turn, it may foster the growth ..
  8. Innate Immunity and RSV Infection in Children
    Theresa Guilbert; Fiscal Year: 2007
    Theresa Guilbert is an Assistant Professor in the Department of Pediatrics and the Arizona Respiratory Center (ARC) at the University of Arizona. Dr...
  9. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2008
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  10. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  11. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2008
    ..abstract_text> ..
  12. Coupling & Reconfiguration of Rhythmic Motor Networks
    Stephen Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. PLASTICITY OF SPINAL RESPIRATORY SYNAPTIC TRANSMISSION
    Stephen Johnson; Fiscal Year: 2001
    ....
  14. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
  15. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2008
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." [unreadable] [unreadable] [unreadable]..
  16. Functional Plasticity in Hypoglossal Motoneurons
    JACK FELDMAN; Fiscal Year: 2008
    ..If these pathologies are to be understood, the mechanisms controlling the output of respiratory motoneurons needs to be determined. ..
  17. Nonlinear Analysis of Heart Rate Variability
    Chi Sang Poon; Fiscal Year: 2009
    ..These clinical and modeling studies in turn will showcase the proposed analytical techniques thereby paving the way for their application to other complex biomedical modeling and analysis problems in general. ..
  18. EPISODIC HYPOXIA, HYPOTHALAMUS AND INSULIN RESISTANCE
    Leszek Kubin; Fiscal Year: 2007
    ..The proposed experiments will provide a comprehensive assessment of the relationship between IH and the central mechanisms of insulin resistance, and evaluate the potential for therapeutic interventions. [unreadable] [unreadable]..
  19. Pontomedullary Integration of Respiratory Afferents
    Chi Sang Poon; Fiscal Year: 2010
    ....
  20. Background sodium currents in respiratory pacemakers
    ANDREW TRYBA; Fiscal Year: 2009
    ..This research will lead to better understanding of the ionic mechanisms behind the generation of regular versus irregular rhythmic respiratory activity. ..
  21. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  22. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 2008
    ..Louis, MO.) of infants dying suddenly and unexpectedly to determine if post mortem body temperature indicates involvement of overheating or disorders of thermoregulation in SIDS. [unreadable] [unreadable]..
  23. INTRACELLULAR PH RESPONSES OF CENTRAL CHEMORECEPTORS
    Robert Putnam; Fiscal Year: 2009
    ..We are studying the ways in which neurons respond to CO2 to identify novel drug targets and to test a new theory that this pathway involves several different signals. ..
  24. SCLERODERMA LUNG STUDY
    Robert Wise; Fiscal Year: 2003
    ..abstract_text> ..
  25. NEUROENDOCRINE CONTROL OF REPRODUCTIVE BEHAVIOR
    LAUREN RITERS; Fiscal Year: 2003
    ..In addition, this research could lay the groundwork for future studies on the etiology of disorders related to sexual arousal...
  26. Heart Rate Variability in Mecp2 Deficient Mice
    JOHN BISSONNETTE; Fiscal Year: 2005
    ..These studies will contribute to the understanding of depressed parasympathetic activity in Rett syndrome. ..
  27. Leak potassium channels in chemosensitive RTN neurons
    DANIEL MULKEY; Fiscal Year: 2006
    ..Results from these experiments will determine if TASK currents are present in pH-sensitive RTN neurons and provide insight into the cellular mechanism of mechanism chemoreception. [unreadable] [unreadable]..
  28. DOPAMINE AND PLASTICITY IN RESPIRATORY CONTROL
    Rebecca Johnson; Fiscal Year: 2002
    ..End of Abstract) ..
  29. 8th Sleep and Breathing Symposium
    Leszek Kubin; Fiscal Year: 2002
    ..abstract_text> ..
  30. Neuromorphic Electronic Model of Synaptic Plasticity
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. SYNAPTIC MECHANISMS IN RESPIRATORY CONTROL
    Chi Sang Poon; Fiscal Year: 2002
    ..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
  32. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  33. PERIPHERAL CHEMORECEPTORS: MECHANISMS & MODULATIONS
    Sukhamay Lahiri; Fiscal Year: 2003
    ..The aim of this proposal is to understand how the processes are initiated in the chemosensory cells. ..
  34. Cognitive Modulation of Human Neuroendocrine Stress Axis
    James Abelson; Fiscal Year: 2005
    ..Existing animal data will be used to identify factors within the cognitive intervention which likely account for its potency and dismantling studies will be done to examine the separable effects of these factors. ..
  35. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
    ..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
  36. VOLATILE ANESTHETICS AND RESPIRATORY NEUROTRANSMISSION
    Eckehard Stuth; Fiscal Year: 2009
    ....
  37. Integrative Models of Neural Adaptive Control
    Chi Sang Poon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  38. A Neural Interface for Coordinating Speech and Breathing
    Michael Smotherman; Fiscal Year: 2008
    ..Thus, a more thorough understanding of how and where in the brain this is achieved could reveal the neurological basis of some human speech disorders, such as stuttering, disarthria and apraxia. [unreadable] [unreadable] [unreadable]..
  39. Xth Oxford Conference on Modeling and Control of Breathing
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. The Placebo Effect in Asthma
    Robert Wise; Fiscal Year: 2005
    ..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
  41. MECHANISMS AND LOCALIZATION OF CO2 SENSITIVE CNS NEURONS
    George Richerson; Fiscal Year: 2005
    ..Understanding the basic mechanisms involved in modulation of neuronal activity by CO2, and the mechanisms by which breathing is affected by sleep, may help provide successful treatment for these diseases. ..
  42. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007
    ..Pre-specified subgroup analyses will be conducted to determine if there are clinical or demographic characteristics that predict benefit from treatment of GERD in asthma. ..
  43. Network mechanisms for respiratory rhythm generation
    Nicholas Mellen; Fiscal Year: 2008
    ..We propose to test this hypothesis at the network level, by selectively modulating VIEB and VDEB networks, and at the single neuron level, by characterizing perturbation responses in synaptically isolated VIEBs and VDEBs. ..
  44. Neurochemical Organization of Brain Stem Respiratory Nuclei
    MARGARET TT WONG RILEY; Fiscal Year: 2010
    ....