Articular cartilage and subchondral bone in the pathogenesis of osteoarthritisMary B Goldring
The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
Ann N Y Acad Sci 1192:230-7. 2010
..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
The role of cytokines in osteoarthritis pathophysiologyJulio C Fernandes
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Biorheology 39:237-46. 2002
..Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression...
- Osteoarthritis cartilage histopathology: grading and staging
K P H Pritzker
Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
Osteoarthritis Cartilage 14:13-29. 2006
..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
- Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering
Stephen M Richardson
Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
J Cell Physiol 222:23-32. 2010
Defects of load-bearing connective tissues such as articular cartilage and intervertebral disc (IVD) can result from trauma, degenerative, endocrine, or age-related disease...
- Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
Tadashi Hayami
Department Molecular Endocrinology and Bone Biology, Merck Res. Labs, West Point, PA 19486, USA
Bone 38:234-43. 2006
..Using a modified Mankin scoring system, we demonstrate that articular cartilage damage occurs within 2 weeks post-surgery in both surgical models...
- Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
Yasunobu Sawaji
Imperial College London, London, UK
Arthritis Rheum 58:3498-509. 2008
Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage.
- The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
Tadashi Hayami
Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Arthritis Rheum 50:1193-206. 2004
..ALN treatment reduced the local release of active TGF beta, possibly via inhibition of MMP-13 expression in articular cartilage and MMP-9 expression in subchondral bone...
- Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis
C G Peterfy
Synarc, Inc, San Francisco, CA 94105, USA
Osteoarthritis Cartilage 12:177-90. 2004
..To determine the inter-observer agreement of this scoring method. To examine associations among the features included in the scoring method...
- Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells
R Kuroda
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
Osteoarthritis Cartilage 15:226-31. 2007
..This study assessed the effectiveness of autologous bone-marrow stromal cells, which were embedded within a collagen scaffold, to repair a full-thickness articular cartilage defect in the medial femoral condyle of an athlete.
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
Francesco Dell'accio
Barts and the London School of Medicine and Dentistry, London, UK
Arthritis Rheum 58:1410-21. 2008
To characterize the molecular response of adult human articular cartilage to acute mechanical injury.
- Mechanisms for asporin function and regulation in articular cartilage
Masahiro Nakajima
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 282:32185-92. 2007
..OA is characterized by the loss of articular cartilage; however, the details of its etiology and pathogenesis remain unclear...
- The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology
Michael A Adams
Department of Anatomy, University of Bristol, Bristol, UK
Matrix Biol 28:384-9. 2009
Degeneration of intervertebral discs and articular cartilage can cause pain and disability. Risk factors include genetic inheritance and age, but mechanical loading also is important...
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertElena V Tchetina
Shriners Hospitals for Children, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
Arthritis Res Ther 9:R75. 2007
..OA) cartilage and is itself capable of downregulating collagen cleavage and hypertrophy in human OA articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with a wide range ..
- Type III collagen, a fibril network modifier in articular cartilage
Jiann Jiu Wu
Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 285:18537-44. 2010
The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens...
- Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis
Kai Mithoefer
Harvard Vanguard Orthopedics and Sports Medicine, Brigham and Women s Faulkner Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Sports Med 37:2053-63. 2009
Despite the popularity of microfracture as a first-line treatment for articular cartilage defects in the knee, systematic information on its clinical efficacy for articular cartilage repair and long-term improvement of knee function is ..
- In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
X Li
Musculo skeletal Quantitative Imaging Research, Department of Radiology, University of California at San Francisco, San Francisco, CA 94107, USA
Osteoarthritis Cartilage 15:789-97. 2007
..The objective of this study was to determine the ability of MR T1rho (T(1rho)) and T(2) mapping to detect cartilage matrix degeneration between normal and early OA patients...
- Osteophytes: relevance and biology
Peter M van der Kraan
Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
Osteoarthritis Cartilage 15:237-44. 2007
..Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes...
- Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
R I Bolbos
Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California San Francisco, San Francisco, CA 94107, USA
Osteoarthritis Cartilage 16:1150-9. 2008
..To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3Tesla (3T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging...
- Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
J H Lee
Discovery Research, Centocor Research and Development, Radnor, PA 19087, USA
Osteoarthritis Cartilage 17:613-20. 2009
..This study was undertaken to determine if resistin is present in the joint following joint injury and to elucidate the role of resistin in cartilage degradation...
- An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee
Robert J Buck
StatAnswers Consulting LLC, San Diego, California 92122, USA
Magn Reson Med 63:680-90. 2010
..These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage...
- Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis
Jiang Wu
Wyeth Research, Cambridge, Massachusetts 02140, USA
Arthritis Rheum 56:3675-84. 2007
To identify potential molecular mediators and biomarkers for osteoarthritis (OA), through comparative proteomic analysis of articular cartilage tissue obtained from normal donors without OA (n = 7) and patients with OA (n = 7).
- Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
Shigeyuki Wakitani
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
J Tissue Eng Regen Med 1:74-9. 2007
..the effectiveness of autologous culture-expanded bone marrow mesenchymal cell transplantation for repairing articular cartilage defects, we transplanted autologous culture-expanded bone marrow mesenchymal cells into nine full-thickness ..
- Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro
J Wang
Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Osteoarthritis Cartilage 11:801-9. 2003
OBJECTIVE: In normal articular cartilage cells, the IGFRI/insulin-like growth factor 1 (IGF-1) autocrine pathway was shown to overrule the catabolic effects of the IL-1/IL-1RI pathway by up-regulation of the IL-1RII decoy receptor...
- Cell death and apoptosis in osteoarthritic cartilage
H A Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, Korea
Curr Drug Targets 8:333-45. 2007
..Because the cardinal feature of OA is a progressive loss of articular cartilage, a great portion of the research endeavour into the pathogenesis of OA has been focused on the regulation ..
- Articular cartilage defects: study of 25,124 knee arthroscopies
W Widuchowski
Department of the Knee Surgery, Arthroscopy and Sports Traumatology of the District Hospital of Traumatology, ul Bytomska 62, 41 940 Piekary Slaskie, Poland
Knee 14:177-82. 2007
This retrospective study aimed to provide data on the prevalence, epidemiology and etiology of the knee articular cartilage lesions and describe and estimate, on the ground of a large database, the number of patients who might benefit ..
- Articular cartilage defects in 1,000 knee arthroscopies
Karin Hjelle
Department of Orthopaedics, Deaconess Hospital, Haraldsplass, University of Bergen, Norway
Arthroscopy 18:730-4. 2002
..3%, 6.1%, and 7.1% of all arthroscopies, respectively. CONCLUSIONS: Our study supports the contention that articular cartilage defects are common...
- Animal models of osteoarthritis
Kenneth D Brandt
Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Biorheology 39:221-35. 2002
..an effect, although diacerhein and glucosamine have recently been reported to lower the rate of loss of articular cartilage in patients with hip OA and knee OA, respectively, based on measurements of the rate of joint space ..
- Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
Xin Li
Rush University Medical Center, Chicago, Illinois
Arthritis Rheum 60:513-23. 2009
..To elucidate the pathophysiologic links between prostaglandin E(2) (PGE(2)) and osteoarthritis (OA) by characterizing the catabolic effects of PGE(2) and its unique receptors in human adult articular chondrocytes...
- Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells
Ryosuke Kuroda
Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Arthritis Rheum 54:433-42. 2006
..bone morphogenetic protein 4 (BMP-4) to differentiate into chondrocytes in vitro and in vivo and enhance articular cartilage repair...
- Knee structural alteration and BMI: a cross-sectional study
Changhai Ding
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Obes Res 13:350-61. 2005
..Knee articular cartilage defect score (0 to 4) and prevalence (defect score of >/=2), volume, and thickness, as well as bone surface ..
- Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
Kazuo Yudoh
Department of Bioregulation, Institute of Medical Science, St, Marianna University, Kawasaki City, Japan
Arthritis Res Ther 7:R380-91. 2005
..Human chondrocytes and articular cartilage explants were isolated from knee joints of patients undergoing arthroplastic knee surgery for OA...
- Articular cartilage and osteoarthritis
Joseph A Buckwalter
Department of Orthopaedics, University of Iowa, Iowa City, USA
Instr Course Lect 54:465-80. 2005
b>Articular cartilage, which makes possible the painless, low-friction movement of synovial joints, consists of a sparsely distributed population of highly specialized cells called chondrocytes that are embedded within a matrix and provide ..
- Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
B C Sondergaard
Nordic Bioscience Diagnostics, Herlev, Denmark
Osteoarthritis Cartilage 14:759-68. 2006
..In bovine articular cartilage explants, cartilage degradation was investigated by release of C-terminal telopeptides of collagen type II (..
- Update on advanced surgical techniques in the treatment of traumatic focal articular cartilage lesions in the knee
Nicholas A Sgaglione
Division of Sports Medicine, North Shore University Hospital, Manhasset, New York, USA
Arthroscopy 18:9-32. 2002
..has been developed over the past several years in expanding the treatment of symptomatic femoral condylar articular cartilage lesions in active patients...
- Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation
D M Salter
Department of Pathology, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
Biorheology 39:97-108. 2002
Mechanical stimulation is critically important for the maintenance of normal articular cartilage integrity. Molecular events regulating responses of chondrocytes to mechanical forces are beginning to be defined...
- Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
Mehdi Shakibaei
Institute of Anatomy, Musculoskeletal Research Group, Ludwig Maximilian University Munich, Pettenkoferstrasse 11, D 80336 Munich
Ann N Y Acad Sci 1095:554-63. 2007
..These findings suggest that this dietary polyphenolic compound may have future applications in the nutraceutical-based therapy of human and animal OA...
- Biosynthetic response and mechanical properties of articular cartilage after injurious compression
B Kurz
Anatomisches Institut der CAU Kiel, Germany
J Orthop Res 19:1140-6. 2001
Traumatic joint injury is known to produce osteoarthritic degeneration of articular cartilage. To study the effects of injurious compression on the degradation and repair of cartilage in vitro, we developed a model that allows strain and ..
- Basic FGF mediates an immediate response of articular cartilage to mechanical injury
Tonia Vincent
The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, 1 Aspenlea Road, London W6 8LH, UK
Proc Natl Acad Sci U S A 99:8259-64. 2002
..ERK), one of the three types of mitogen-activated kinases, was rapidly activated after cutting porcine articular cartilage either when maintained as explants or in situ...
- Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes
V I Grishko
Department of Cell Biology, University of South Alabama, Mobile, AL 36688 0002, USA
Osteoarthritis Cartilage 17:107-13. 2009
..The aim of this study was to determine whether mtDNA damage was present in OA chondrocytes, and whether mtDNA repair capacity is compromised in OA chondrocytes following oxidative stress, leading to chondrocyte death...
- Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
Nicole Verzijl
TNO Prevention and Health, Leiden, The Netherlands
Arthritis Rheum 46:114-23. 2002
..We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. METHODS: To increase AGE levels, human adult articular cartilage was incubated with threose...
- Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes
E Maneiro
Laboratory of Investigation, Rheumatology Division, Juan Canalejo Hospital, C/Xubias 84, , Spain
Ann Rheum Dis 64:388-95. 2005
..CONCLUSIONS: This study suggests that the effect of NO on chondrocyte survival is mediated by its effect on complex IV of the MRC...
- Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo
C De Bari
University Hospitals Katholieke Universiteit Leuven, Belgium
Arthritis Rheum 44:1608-19. 2001
..This cartilage-forming ability in vivo may be pivotal for successful cell-based joint surface defect repair protocols...
- Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis
Lin Xu
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
Arthritis Rheum 56:2663-73. 2007
..To investigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis of osteoarthritis (OA)...
- Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
L A Neuhold
Molecular Genetics Division, Wyeth Ayerst Research, Princeton, New Jersey, USA
J Clin Invest 107:35-44. 2001
..Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA...
- Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells
Jung Park
Department of Oro-Maxillo-Facial Surgery, University of Erlangen-Nuernberg, Germany
J Gene Med 8:112-25. 2006
..cells of different origin which can be obtained with minor donor site morbidity are considered for articular cartilage repair. This study aims at a comparison of their chondrogenic potential...
- In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage
Constance R Chu
Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E1640, Pittsburgh, PA 15261, USA
J Bone Joint Surg Am 92:599-608. 2010
..This in vivo study was conducted to determine whether a single intra-articular injection of 0.5% bupivacaine results in chondrocyte morbidity and rapid chondrolysis...
- The efficacy of intra-articular hyaluronan injection after the microfracture technique for the treatment of articular cartilage lesions
Eric Strauss
Musculoskeletal Research Center, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, USA
Am J Sports Med 37:720-6. 2009
..Although the exact mechanism of action has yet to be elucidated, recent animal studies have demonstrated chondroprotective and anti-inflammatory properties of hyaluronic acid viscosupplementation...
- Age-related changes in the morphology and deformational behavior of knee joint cartilage
M Hudelmaier
, Munich, Germany
Arthritis Rheum 44:2556-61. 2001
..We show that under in vivo loading conditions, elderly subjects display a lower level of cartilage deformation than do healthy young subjects...
- A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis
Eiki Koyama
Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
Dev Biol 316:62-73. 2008
..as Wnt9a, Erg and collagen IIA, remained predominant in the joint-forming sites over time, gave rise to articular cartilage, synovial lining and other joint tissues, but contributed little if any to underlying growth plate ..
- Molecular characterization and methylation study of matrix gla protein in articular cartilage from pig with osteochondrosis
Watchara Laenoi
Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Germany
Gene 459:24-31. 2010
..The porcine MGP gene consists of 4 exons and 3 introns. The full-length MGP cDNA isolated from articular cartilage consists of 606 bp with a 69-bp 5' UTR, a 312-bp open reading frame with a start codon, a 225-bp 3' UTR...
- Chondroitinase ABC treatment results in greater tensile properties of self-assembled tissue-engineered articular cartilage
Roman M Natoli
Department of Bioengineering, Rice University, Houston, Texas 77005, USA
Tissue Eng Part A 15:3119-28. 2009
Collagen content and tensile properties of engineered articular cartilage have remained inferior to glycosaminoglycan (GAG) content and compressive properties...
- Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage
Arijitt Borthakur
MMRRCC, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104-6100, USA
NMR Biomed 19:781-821. 2006
..The current status of T1rho relaxation mapping of cartilage and future directions is also discussed...
- Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes
Monika Hermansson
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, W6 8LH, UK
J Biol Chem 279:43514-21. 2004
We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry...
- The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee
C G Peterfy
Synarc Inc, San Francisco, CA 94105, USA
Osteoarthritis Cartilage 16:1433-41. 2008
..To report on the process and criteria for selecting acquisition protocols to include in the osteoarthritis initiative (OAI) magnetic resonance imaging (MRI) study protocol for the knee...
- Collagens of articular cartilage: structure, function, and importance in tissue engineering
Donald J Responte
Department of Bioengineering, Rice University, Houston, Texas 77005, USA
Crit Rev Biomed Eng 35:363-411. 2007
Collagen is a crucial matrix component of articular cartilage. Because articular cartilage is a load bearing tissue, developing mechanical integrity is a central goal of tissue engineering...
- Articular cartilage restoration of the knee
Mehul R Shah
NYU Hospital for Joint Diseases, Department of Orthopaedic Surgery, New York, New York, USA
Bull NYU Hosp Jt Dis 65:51-60. 2007
b>Articular cartilage defects are common and play a significant role in degenerative joint disease...
- Site-specific effects of compression on macromolecular diffusion in articular cartilage
Holly A Leddy
Department of Surgery and Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710, USA
Biophys J 95:4890-5. 2008
b>Articular cartilage is the connective tissue that lines joints and provides a smooth surface for joint motion...
- Outcomes of full-thickness articular cartilage injuries of the shoulder treated with microfracture
Peter J Millett
Steadman Hawkins Clinic and Steadman Hawkins Research Foundation, Vail, CO 81657, USA
Arthroscopy 25:856-63. 2009
..The purpose of this study was to determine whether microfracture provides pain relief and improves shoulder function in patients with chondral defects of the glenohumeral joint...
- Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics
S Saarakkala
Department of Physics, University of Kuopio, Kuopio, Finland
Osteoarthritis Cartilage 18:73-81. 2010
Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e...
- A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage
S D Waldman
Department of Mechanical and Materials Engineering, Queen s University, Kingston, Ontario, Canada
Osteoarthritis Cartilage 14:323-30. 2006
..Thus, the purpose of this study was to investigate the effect of a single application of cyclic loading to chondrocytes on the formation and properties of in vitro-formed tissue...
- Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance
Cristina Ruiz-Romero
Osteoarticular and Aging Research Laboratory, Proteomics Unit Nodo Asociado de Proteo Red, Rheumatology Division, Instituto de Investigación Biomédica de A Coruña Complejo Hospitalario Universitario A Coruña, Xubias 84, Spain
Mol Cell Proteomics 8:172-89. 2009
....
- A direct compression stimulator for articular cartilage and meniscal explants
Adam C AufderHeide
Department of Bioengineering, Rice University, Houston, Texas 77251, USA
Ann Biomed Eng 34:1463-74. 2006
..and use of a direct compression stimulator for culturing explants from the meniscus of the knee and articular cartilage. Following design and fabrication of the instrument along with its data acquisition system, the function of ..
- Morphological studies on the ageing and osteoarthritis of the articular cartilage in C57 black mice
K Yamamoto
Department of Orthopedic Surgery, Tokyo Medical University, Tokyo, Japan
J Orthop Surg (Hong Kong) 13:8-18. 2005
To study the cause and mechanism of joint degeneration in osteoarthritis, through histopathological and ultrastructural-histochemical experiments on the articular cartilage of the knees of the C57 black mouse.
- Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage
Shuhei Otsuki
Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Arthritis Res Ther 10:R61. 2008
..The aim of this study was to analyze expression patterns of recently identified extracellular sulfatases Sulf-1 and Sulf-2 in articular cartilage and chondrocytes.
- Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears
Constance R Chu
Cartilage Restoration Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Arthritis Rheum 62:1412-20. 2010
Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to the evaluation of potential disease-modifying treatments in osteoarthritis (OA)...
- A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect
Kazunori Yasuda
Department of Sports Medicine and Joint Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Macromol Biosci 9:307-16. 2009
..This study prompted an innovative strategy in the field of joint surgery to repair an osteochondral defect using an advanced, high-function hydrogel...
- Assessment of depth and degeneration dependences of articular cartilage refractive index using optical coherence tomography in vitro
Shu Zhe Wang
Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, China
Connect Tissue Res 51:36-47. 2010
..of 15 mum was used to investigate the depth and degeneration dependences of the refractive index (RI) of articular cartilage collected from bovine patellae in vitro. Eighteen disks of articular cartilage with a diameter of 6...
- Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets
H I Roach
Bone and Joint Research Group, Division of Developmental Origins of Health and Disease, University of Southampton, UK
Curr Drug Targets 8:271-82. 2007
..Altogether, there is a plethora of tissues, disease processes and targets for treating osteoarthritic joint degeneration, which will need to be followed up systematically in the future...
- Proteoglycan-induced changes in T1rho-relaxation of articular cartilage at 4T
S V Akella
Department of Radiology Stellar Chance Laboratories, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6100, USA
Magn Reson Med 46:419-23. 2001
..depletion-induced changes in T1rho (spin-lattice relaxation in rotating frame) relaxation and dispersion in articular cartilage were studied at 4T...
- The role of relaxation times in monitoring proteoglycan depletion in articular cartilage
V Mlynarik
MR and Osteology, Department of Radiology, University of Vienna, 1090 Vienna, Austria
J Magn Reson Imaging 10:497-502. 1999
..T2, T1rho, and gadolinium-diethylene triamine pentaacetic acid [Gd-DTPA]-enhanced T1) were measured in articular cartilage in vitro at 3 T to assess their role in visualizing proteoglycan depletion...
- Experimental results of donor site filling for autologous osteochondral mosaicplasty
Péter Feczkó
Orthopaedic and Trauma Department Uzsoki Hospital, Budapest, Hungary
Arthroscopy 19:755-61. 2003
....
- Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500-730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee
D D Guidolin
Fidia Research Laboratories, Abano Terme, Italy
Osteoarthritis Cartilage 9:371-81. 2001
..The results obtained with hyaluronan were compared with the results of methylprednisolone acetate treatment...
- Osteoarthritis
Mary B Goldring
Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
J Cell Physiol 213:626-34. 2007
Osteoarthritis (OA) is characterized by degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and changes in peri-articular and subchondral bone...
- A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading
Clark T Hung
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Ann Biomed Eng 32:35-49. 2004
....
- Topographic and zonal distribution of tenascin in human articular cartilage from femoral heads: normal versus mild and severe osteoarthritis
K Veje
Osteoarthritis Research Unit, Institute for Inflammation Research, Rigshospitalet National University Hospital, Copenhagen, Denmark
Osteoarthritis Cartilage 11:217-27. 2003
The extracellular matrix glycoprotein tenascin (TN) is upregulated in articular cartilage with severe osteoarthritis (OA)...
- Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects
Nobuo Adachi
Department of Orthopaedic Surgery, Children's Hospital of Pittsburgh, and University of Pittsburgh, Pennsylvania 15213, USA
J Rheumatol 29:1920-30. 2002
..allogeneic muscle derived cells (MDC) embedded in collagen gels for the treatment of full thickness articular cartilage defects, to compare the results to those from chondrocyte transplantation, and to evaluate the feasibility ..
- Osteoarthritis: a tale of three tissues
Jonathan Samuels
New York University School of Medicine, New York, NY, USA
Bull NYU Hosp Jt Dis 66:244-50. 2008
While research in osteoarthritis has focused on the events that lead to the destruction of articular cartilage, recent evidence suggests that two other components of the joints-bone and synovium-also play key roles in pathogenesis...
- IL-1beta and BMPs--interactive players of cartilage matrix degradation and regeneration
T Aigner
Institute of Pathology, University of Leipzig, 04103 Leipzig, Germany
Eur Cell Mater 12:49-56; discussion 56. 2006
Intact human adult articular cartilage is central for the functioning of the articulating joints...
- In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
B Johnstone
Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
Exp Cell Res 238:265-72. 1998
..These results provide histological, immunohistochemical, and molecular evidence for the in vitro chondrogenic differentiation of adult mammalian progenitor cells derived from bone marrow...
- Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
R C Billinghurst
Department of Surgery, McGill University, Montreal, Quebec, Canada
J Clin Invest 99:1534-45. 1997
..that collagenase(s) produced by chondrocytes is (are) involved in the cleavage and denaturation of type II collagen in articular cartilage, that this is increased in OA, and that MMP-13 may play a significant role in this process.
- Double echo steady state magnetic resonance imaging of knee articular cartilage at 3 Tesla: a pilot study for the Osteoarthritis Initiative
F Eckstein
Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Strubergasse 21, A5020 Salzburg, Austria
Ann Rheum Dis 65:433-41. 2006
..Quantitative magnetic resonance imaging (qMRI) may provide valuable measures of cartilage morphology in osteoarthritis (OA) but has been confined to sequences with relatively long acquisition times at 1.5 Tesla (T)...
- The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage
V C Mow
Orthopaedic Research Laboratory, Columbia University, New York, NY 10032, USA
Osteoarthritis Cartilage 7:41-58. 1999
....
- Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study
F M Cicuttini
Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, Melbourne, Australia
Ann Rheum Dis 63:1124-7. 2004
..To determine whether cartilage volume loss is an independent predictor of knee replacement...
- Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta
Martina Kaiser
Osteoarticular and Artheritis Research, Dept, or Pathology, University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
Arthritis Rheum 50:3535-40. 2004
....
- Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage
V Moos
Deutsches Rheuma Forschungzentrum, Department of Medicine, Klinikum Benjamin Franklin, Free University, Berlin, Germany
J Rheumatol 26:870-9. 1999
..To investigate osteoarthritic cartilage in comparison to normal cartilage in humans for the presence of the most relevant cytokines/growth factors known to be important for degradation and formation of new cartilage...
- Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta
L J Sandell
Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, United States
Osteoarthritis Cartilage 16:1560-71. 2008
..To provide a more complete picture of the effect of interleukin-1 beta (IL-1beta) on adult human articular chondrocyte gene expression, in contrast to the candidate gene approach...
- Change in knee cartilage T2 at MR imaging after running: a feasibility study
Timothy J Mosher
Pennsylvania State University Center for NMR Research, Department of Radiology, Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Radiology 234:245-9. 2005
..Quantitative magnetic resonance (MR) T2 maps of weight-bearing femoral and tibial articular cartilage were obtained in seven young healthy men before and immediately after 30 minutes of running by using a 3...
- Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism
Raina Petrov
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Osteoarthritis Cartilage 13:250-7. 2005
..DESIGN: Articular cartilage was obtained from the metacarpophalangeal joints of 10 young adult horses...
- Histologic findings and possible causes of osteochondritis dissecans of the knee
Hiroaki Uozumi
Department of Orthopaedic Surgery, Tohoku University School of Medicine, 1 1 Seiryomachi, Aoba ku, Sendai City, 980 8574, Japan
Am J Sports Med 37:2003-8. 2009
..Hypothesis The differences in the histologic findings of osteochondritis dissecans might represent a course of pathologic progression...
- Functional analysis of articular cartilage deformation, recovery, and fluid flow following dynamic exercise in vivo
F Eckstein
Muskuloskeletal Research Group, Anatomische Anstalt der Ludwig Maximilians Universität, Pettenkoferstrasse 11, D 80336 MUnchen, Germany
Anat Embryol (Berl) 200:419-24. 1999
The function of articular cartilage depends on the interaction between the tissue matrix and the interstitial fluid bound to the proteoglycan molecules...
- Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
R Serra
Department of Cell Biology and the Vanderbilt Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
J Cell Biol 139:541-52. 1997
..DNIIR mRNA expression was localized to the periosteum/perichondrium, syno-vium, and articular cartilage. Lower levels of DNIIR mRNA were detected in growth plate cartilage...
- IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
M Chabaud
INSERM U403, , and Departments of Immunology and Rheumatology, , Lyon, France
Arthritis Res 3:168-77. 2001
..In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA...
- Treatment of osteochondral defects of the talus
C J A van Bergen
Department of Orthopaedic Surgery, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DD Amsterdam, The Netherlands
Rev Chir Orthop Reparatrice Appar Mot 94:398-408. 2008
..Osteochondral autograft transfer and autologous chondrocyte implantation (ACI), with or without a cancellous bone graft, are recommended for secondary cases as well as large lesions...
- Hypoxic resistance to articular chondrocyte apoptosis--a possible mechanism of maintaining homeostasis of normal articular cartilage
J W Seol
Center for Healthcare Technology Development, Bio Safety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk, South Korea
FEBS J 276:7375-85. 2009
..Furthermore, the maintenance of hypoxic conditions or therapy with hypoxia-related genes in the joint may be successful for the treatment of joint-related diseases, including osteoarthritis...
- Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis
S Groeneboer
Department of Rheumatology, Ghent University Hospital, University of Ghent, Ghent, Belgium
Osteoarthritis Cartilage 16:986-93. 2008
..To evaluate the in vivo chondroprotective effect of cyclodextrin polysulphate (CDPS) in a rabbit model of experimental osteoarthritis (OA)...
- Lead accumulation in tidemark of articular cartilage
N Zoeger
Vienna University of Technology, Atominstitut, Stadionallee 2, 1020 Vienna, Austria
Osteoarthritis Cartilage 14:906-13. 2006
Determination of the spatial distribution of the toxic element lead (Pb) and other trace elements in normal articular cartilage and subchondral bone from adult humans with no history of work-related exposure to Pb.
- Early exercise advances the maturation of glycosaminoglycans and collagen in the extracellular matrix of articular cartilage in the horse
P R van Weeren
Global Equine Research Alliance Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, NL 3584 CM Utrecht, The Netherlands
Equine Vet J 40:128-35. 2008
Training at a very young age may influence the characteristics of the collagen network of articular cartilage extracellular matrix (ECM) in horses.
- Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration
Ilona Polur
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
Histol Histopathol 25:599-608. 2010
This study is to investigate the possible role of high temperature requirement A 1 (HtrA1) in the articular cartilage degeneration...
- Collagen synthesis of articular cartilage explants in response to frequency of cyclic mechanical loading
Amela Wolf
Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University Clinics Giessen and Marburg, Paul Meimberg Strasse 3, 35385 Giessen, Germany
Cell Tissue Res 327:155-66. 2007
b>Articular cartilage in vivo experiences the effects of both cell-regulatory proteins and mechanical forces...
- Articular cartilage, degenerative process, and repair: current progress
M F L'Hermette
Department of Orthopedics, Centre Hospitalo Universitaire de Rouen, GRHAL Laboratory, Rouen, France
Int J Sports Med 27:738-44. 2006
The aim of this paper is to review the current knowledge about degenerative and repair process of articular cartilage, and relationship between osteoarthritis and physical activities...
- Histologic changes in articular cartilage after medial meniscus replacement in rabbits
Paul C Rijk
Department of Orthopaedic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
Arthroscopy 20:911-7. 2004
..but it remains to be established whether meniscal transplantation can prevent long-term degeneration of articular cartilage. This study examined whether immediate or delayed transplantation of the medial meniscus can protect the ..
