- Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
Mary B Goldring
The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
Ann N Y Acad Sci 1192:230-7. 2010
..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
- The subchondral bone in articular cartilage repair: current problems in the surgical management
Andreas H Gomoll
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the ..
- The role of cytokines in osteoarthritis pathophysiology
Julio C Fernandes
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Biorheology 39:237-46. 2002
..Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression...
- An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
Botnar Research Centre, University of Oxford, UK
Hum Mol Genet 16:2226-32. 2007
..A small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to OA...
- Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
Bone 38:234-43. 2006
..Using a modified Mankin scoring system, we demonstrate that articular cartilage damage occurs within 2 weeks post-surgery in both surgical models...
Mary B Goldring
Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
J Cell Physiol 213:626-34. 2007
Osteoarthritis (OA) is characterized by degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and changes in peri-articular and subchondral bone...
- Strategies for articular cartilage lesion repair and functional restoration
Tamer A E Ahmed
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Tissue Eng Part B Rev 16:305-29. 2010
Injury of articular cartilage due to trauma or pathological conditions is the major cause of disability worldwide, especially in North America...
- Characterization of metalloprotease cleavage products of human articular cartilage
Eugene Y Zhen
Eli Lilly and Company, Greenfield, IN 46140, USA
Arthritis Rheum 58:2420-31. 2008
To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage.
- Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
Imperial College London, London, UK
Arthritis Rheum 58:3498-509. 2008
Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage.
- Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
Osteoarthritis Cartilage 15:226-31. 2007
..This study assessed the effectiveness of autologous bone-marrow stromal cells, which were embedded within a collagen scaffold, to repair a full-thickness articular cartilage defect in the medial femoral condyle of an athlete.
- Tissue engineering of stratified articular cartilage from chondrocyte subpopulations
T J Klein
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
Osteoarthritis Cartilage 11:595-602. 2003
..Constructs were cultured for 1 or 2 weeks and were assessed for growth, compressive properties, and deposition, and localization of matrix molecules and superficial zone protein (SZP)...
- Articular cartilage and osteoarthritis
Joseph A Buckwalter
Department of Orthopaedics, University of Iowa, Iowa City, USA
Instr Course Lect 54:465-80. 2005
b>Articular cartilage, which makes possible the painless, low-friction movement of synovial joints, consists of a sparsely distributed population of highly specialized cells called chondrocytes that are embedded within a matrix and provide ..
- Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics
Department of Physics, University of Kuopio, Kuopio, Finland
Osteoarthritis Cartilage 18:73-81. 2010
Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e...
- The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage
Orthopaedic Research Laboratories, Department of Surgery, Division of Orthopaedic Surgery, 375 MSRB, Box 3093, Duke University Medical Center, Durham, NC 27710, USA
Ann N Y Acad Sci 1068:498-512. 2006
The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular cartilage, which together with the enclosed cell(s) has been termed the "chondron...
- Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study
Oxford University, Oxford, UK
Arthritis Rheum 50:3915-24. 2004
..information on the gradients of oxygen concentration from the synovial surface to the subchondral bone in articular cartilage. Cartilage is usually regarded as hypoxic, even though cellular metabolism is inhibited at low oxygen ..
- A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
D D Frisbie
Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
Vet Comp Orthop Traumatol 19:142-6. 2006
..on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee...
- Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis
C G Peterfy
Synarc, Inc, San Francisco, CA 94105, USA
Osteoarthritis Cartilage 12:177-90. 2004
..To determine the inter-observer agreement of this scoring method. To examine associations among the features included in the scoring method...
- Mechanisms for asporin function and regulation in articular cartilage
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 282:32185-92. 2007
..OA is characterized by the loss of articular cartilage; however, the details of its etiology and pathogenesis remain unclear...
- The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Arthritis Rheum 50:1193-206. 2004
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
Barts and the London School of Medicine and Dentistry, London, UK
Arthritis Rheum 58:1410-21. 2008
To characterize the molecular response of adult human articular cartilage to acute mechanical injury.
- Rapid phenotypic changes in passaged articular chondrocyte subpopulations
Eric M Darling
Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
J Orthop Res 23:425-32. 2005
Articular chondrocytes are often expanded in vitro and then used to assist in healing articular cartilage defects...
- Extraction techniques for the decellularization of tissue engineered articular cartilage constructs
Benjamin D Elder
Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
Biomaterials 30:3749-56. 2009
..However, limited work has been performed with articular cartilage, and no studies have examined the decellularization of tissue engineered constructs...
- Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage
Gaubius Laboratory, TNO Prevention and Health, 2301 CE Leiden, The Netherlands
Osteoarthritis Cartilage 9:720-6. 2001
..OAs) increases with age and coincides with the accumulation of advanced glycation endproducts (AGEs) in articular cartilage, suggesting that accumulation of glycation products may be involved in the development of OA...
- Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques
Cartilage Repair Center, Brigham and Women s Hospital, Harvard Medical School, 850 Boylston Street, Chestnut Hill, MA 02467, USA
Am J Sports Med 37:902-8. 2009
..Common knowledge holds that these treatments do not compromise subsequent cartilage repair procedures with autologous chondrocyte implantation...
- Aging, articular cartilage chondrocyte senescence and osteoarthritis
James A Martin
Department of Orthopaedics, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Biogerontology 3:257-64. 2002
..of osteoarthritis (OA), the disease characterized by joint pain and loss of joint form and function due to articular cartilage degeneration, is directly correlated with age...
- Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
Allan A Young
Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia
Arthritis Res Ther 7:R852-61. 2005
..form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage. Along with increased production and activation of degradative enzymes, altered synthesis of cartilage ..
- Meniscal allograft transplantation--part II: alternative treatments, effects on articular cartilage, and future directions
Paul C Rijk
Department of Orthopaedic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
Arthroscopy 20:851-9. 2004
..allograft transplantation are evaluated as well as the effect of meniscal allograft transplantation on articular cartilage. Remaining questions and future directions are considered in a final discussion...
- Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity
Department of Plastic Surgery, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
Osteoarthritis Cartilage 13:614-22. 2005
..To test the hypothesis that age-related loss of chondrocytes in cartilage is associated with impaired reactive oxygen species (ROS) homeostasis resulting from reduced antioxidant defence...
- Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
Arthroscopic Surgery Unit, USP La Esperanza Clinic, Vitoria Gasteiz, Basque Country, Spain
Med Sci Sports Exerc 35:1648-52. 2003
..This is attributed to the slow delivery of growth factors from harvested platelets that have been activated by endogenous thrombin promoted by the addition of calcium chloride...
- Morphology and phenotype expression of types I, II, III, and X collagen and MMP-13 of chondrocytes cultured from articular cartilage of Kashin-Beck Disease
Department of Orthopedics Surgery, Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
J Rheumatol 35:696-702. 2008
..expression of types I, II, III, and X collagen and matrix metalloproteinase-13 (MMP-13) of chondrocytes from articular cartilage of adult patients with Kashin-Beck Disease (KBD) in vitro to understand the pathogenesis in chondrocytes.
- The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results
Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey
Arthroscopy 24:1214-20. 2008
The purpose of this study was to determine the effectiveness of the microfracture technique in the treatment of full-thickness articular cartilage lesions of the knee.
- Prospective evaluation of concurrent meniscus transplantation and articular cartilage repair: minimum 2-year follow-up
John Paul H Rue
Department of Orthopaedic Surgery, National Naval Medical Center, Bethesda, Maryland, USA
Am J Sports Med 36:1770-8. 2008
Recognition of the symbiotic relationship between the meniscus and articular cartilage is critical to the success of meniscal allograft transplantation...
- Basic science of articular cartilage and osteoarthritis
Andrew D Pearle
Shoulder and Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
Clin Sports Med 24:1-12. 2005
b>Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface...
- A clinical review of cartilage repair techniques
G D Smith
Robert Jones and Agnes Hunt Orthopaedic Hospital, Gobowen, Oswestry, Shropshire SY10 7AG, England, UK
J Bone Joint Surg Br 87:445-9. 2005
- Outcomes of full-thickness articular cartilage injuries of the shoulder treated with microfracture
Peter J Millett
Steadman Hawkins Clinic and Steadman Hawkins Research Foundation, Vail, CO 81657, USA
Arthroscopy 25:856-63. 2009
..The purpose of this study was to determine whether microfracture provides pain relief and improves shoulder function in patients with chondral defects of the glenohumeral joint...
- The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage
Orthopaedic Research Laboratories, Departments of Surgery, Biomedical Engineering, and Mechanical Engineering and Materials Science, Duke University Medical Center, P O Box 3093, 375 MSRB, 27710, Durham, NC, USA
J Biomech 33:1663-73. 2000
..Based on the existing experimental data on the deformation behavior and biomechanical properties of articular cartilage and chondrocytes, a multi-scale biphasic finite element model was developed of the chondrocyte as a ..
- The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Eindhoven 5600 MB, The Netherlands
Med Eng Phys 27:810-26. 2005
b>Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis degeneration of articular cartilage occurs...
- Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation
Institute of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland
Osteoarthritis Cartilage 17:448-55. 2009
..The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs...
- Calcification of articular cartilage in human osteoarthritis
Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
Arthritis Rheum 60:2694-703. 2009
..The aim of this study was to determine the prevalence and composition of calcium crystals in human OA and analyze their relationship to disease severity and markers of chondrocyte hypertrophy...
- Sensitivities of medial meniscal motion and deformation to material properties of articular cartilage, meniscus and meniscal attachments using design of experiments methods
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA
J Biomech Eng 128:399-408. 2006
This study investigated the role of the material properties assumed for articular cartilage, meniscus and meniscal attachments on the fit of a finite element model (FEM) to experimental data for meniscal motion and deformation due to an ..
- Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypert
Elena V Tchetina
Shriners Hospitals for Children, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
Arthritis Res Ther 9:R75. 2007
..OA) cartilage and is itself capable of downregulating collagen cleavage and hypertrophy in human OA articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with a wide range ..
- Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
J H Lee
Discovery Research, Centocor Research and Development, Radnor, PA 19087, USA
Osteoarthritis Cartilage 17:613-20. 2009
..This study was undertaken to determine if resistin is present in the joint following joint injury and to elucidate the role of resistin in cartilage degradation...
- Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
R I Bolbos
Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California San Francisco, San Francisco, CA 94107, USA
Osteoarthritis Cartilage 16:1150-9. 2008
..To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3Tesla (3T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging...
- An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee
Robert J Buck
StatAnswers Consulting LLC, San Diego, California 92122, USA
Magn Reson Med 63:680-90. 2010
..These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage...
- The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology
Michael A Adams
Department of Anatomy, University of Bristol, Bristol, UK
Matrix Biol 28:384-9. 2009
Degeneration of intervertebral discs and articular cartilage can cause pain and disability. Risk factors include genetic inheritance and age, but mechanical loading also is important...
- Type III collagen, a fibril network modifier in articular cartilage
Jiann Jiu Wu
Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 285:18537-44. 2010
The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens...
- Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase
Young Mee Yoon
National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
J Biol Chem 277:8412-20. 2002
..Chondrocytes isolated from rabbit articular cartilage underwent dedifferentiation upon serial monolayer culture with cessation of type II collagen expression and ..
- Regeneration of degenerated articular cartilage after high tibial valgus osteotomy for medial compartmental osteoarthritis of the knee
Department of Orthopaedic Surgery, Yokohama City University, School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
Knee 10:229-36. 2003
The aim of the current study was to document regeneration of the articular cartilage after correction of varus deformity for osteoarthritis of the knee...
- Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects
Division of Applied Mechanics, Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada
J Biomech 42:2458-65. 2009
b>Articular cartilage and its supporting bone functional conditions are tightly coupled as injuries of either adversely affects joint mechanical environment...
- Current strategies for articular cartilage repair
S N Redman
CITER, Cardiff School of Biosciences, Museum Avenue, Cardiff, CF10 3US, Wales, UK
Eur Cell Mater 9:23-32; discussion 23-32. 2005
Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal spontaneously...
- Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering
Stephen M Richardson
Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
J Cell Physiol 222:23-32. 2010
Defects of load-bearing connective tissues such as articular cartilage and intervertebral disc (IVD) can result from trauma, degenerative, endocrine, or age-related disease...
- In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
Musculo skeletal Quantitative Imaging Research, Department of Radiology, University of California at San Francisco, San Francisco, CA 94107, USA
Osteoarthritis Cartilage 15:789-97. 2007
..The objective of this study was to determine the ability of MR T1rho (T(1rho)) and T(2) mapping to detect cartilage matrix degeneration between normal and early OA patients...
- Quantitative MR microscopy of enzymatically degraded articular cartilage
M T Nieminen
Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland
Magn Reson Med 43:676-81. 2000
Structural changes in bovine patellar articular cartilage, induced by component selective enzymatic treatments, were investigated by measuring tissue T(2) relaxation at 9.4 T...
- Osteophytes: relevance and biology
Peter M van der Kraan
Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
Osteoarthritis Cartilage 15:237-44. 2007
..Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes...
- Engineering complex tissues
Antonios G Mikos
Department of Bioengineering, Rice University, Houston, Texas, USA
Tissue Eng 12:3307-39. 2006
..Anthony Atala offered a clinician's perspective for functional tissue regeneration, and discussed new biomaterials that can be used to develop new regenerative technologies...
- Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage
F L Wang
Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
Osteoarthritis Cartilage 8:161-9. 2000
The purpose of this study was to identify genes that are differentially expressed in normal versus osteoarthritic human articular cartilage as either potential novel therapeutic targets or diagnostic markers of this disease.
- Macroscopic structure of articular cartilage of the tibial plateau: influence of a characteristic matrix architecture on MRI appearance
Douglas W Goodwin
Department of Radiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
AJR Am J Roentgenol 182:311-8. 2004
The purpose of our study was to describe the structural organization of the extracellular matrix of articular cartilage of the tibial plateau and its influence on MRI appearance.
- Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes
Molecular Pathogenesis and Connective Tissue Research Groups, Faculty of Veterinary Science, University of Liverpool, UK
Histol Histopathol 20:1327-38. 2005
b>Articular cartilage is an avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma...
- Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
Kennedy Institute of Rheumatology, Hammersmith, London, U K
Biochem J 313:933-40. 1996
The content of the C-terminal region of aggrecan was investigated in samples of articular cartilage from individuals ranging in age from newborn to 65 years...
- Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro
Department of Surgery, Research Division, University of Basel, Switzerland
J Cell Biochem 81:368-77. 2001
- Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis
Harvard Vanguard Orthopedics and Sports Medicine, Brigham and Women s Faulkner Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Sports Med 37:2053-63. 2009
Despite the popularity of microfracture as a first-line treatment for articular cartilage defects in the knee, systematic information on its clinical efficacy for articular cartilage repair and long-term improvement of knee function is ..
- Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
TNO Prevention and Health, Leiden, The Netherlands
Arthritis Rheum 46:114-23. 2002
..We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage.
- Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix
Department of Orthopaedic Surgery, Medical School, University of Vienna, Waehringer Guertel 18 20, A 1090 Wien, Austria
Biomaterials 26:3617-29. 2005
..Only the matrices seeded with autologous cells in combination with microfracture were able to facilitate the regeneration of hyaline-like cartilage...
- Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products
Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
Arthritis Rheum 44:2562-71. 2001
Progressive destruction of articular cartilage is a hallmark of osteoarthritis (OA) and rheumatoid arthritis (RA). Age-related changes in cartilage may influence tissue destruction and thus progression of the disease...
- Articular cartilage defects: study of 25,124 knee arthroscopies
Department of the Knee Surgery, Arthroscopy and Sports Traumatology of the District Hospital of Traumatology, ul Bytomska 62, 41 940 Piekary Slaskie, Poland
Knee 14:177-82. 2007
This retrospective study aimed to provide data on the prevalence, epidemiology and etiology of the knee articular cartilage lesions and describe and estimate, on the ground of a large database, the number of patients who might benefit ..
- Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis
Wyeth Research, Cambridge, Massachusetts 02140, USA
Arthritis Rheum 56:3675-84. 2007
To identify potential molecular mediators and biomarkers for osteoarthritis (OA), through comparative proteomic analysis of articular cartilage tissue obtained from normal donors without OA (n = 7) and patients with OA (n = 7).
- Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
J Tissue Eng Regen Med 1:74-9. 2007
..the effectiveness of autologous culture-expanded bone marrow mesenchymal cell transplantation for repairing articular cartilage defects, we transplanted autologous culture-expanded bone marrow mesenchymal cells into nine full-thickness ..
- Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells
Children s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Arthritis Rheum 54:433-42. 2006
..study was undertaken to investigate the ability of MDSCs that were retrovirally transduced to express bone morphogenetic protein 4 (BMP-4) to differentiate into chondrocytes in vitro and in vivo and enhance articular cartilage repair.
- Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
Department of Bioregulation, Institute of Medical Science, St, Marianna University, Kawasaki City, Japan
Arthritis Res Ther 7:R380-91. 2005
..Human chondrocytes and articular cartilage explants were isolated from knee joints of patients undergoing arthroplastic knee surgery for OA...
- Knee structural alteration and BMI: a cross-sectional study
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Obes Res 13:350-61. 2005
..To describe the associations among BMI, knee cartilage morphology, and bone size in adults...
- Animal models of osteoarthritis
Kenneth D Brandt
Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Biorheology 39:221-35. 2002
..an effect, although diacerhein and glucosamine have recently been reported to lower the rate of loss of articular cartilage in patients with hip OA and knee OA, respectively, based on measurements of the rate of joint space ..
- Articular cartilage defects in 1,000 knee arthroscopies
Department of Orthopaedics, Deaconess Hospital, Haraldsplass, University of Bergen, Norway
Arthroscopy 18:730-4. 2002
- Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
Rush University Medical Center, Chicago, Illinois
Arthritis Rheum 60:513-23. 2009
..To elucidate the pathophysiologic links between prostaglandin E(2) (PGE(2)) and osteoarthritis (OA) by characterizing the catabolic effects of PGE(2) and its unique receptors in human adult articular chondrocytes...
- Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro
Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Osteoarthritis Cartilage 11:801-9. 2003
In normal articular cartilage cells, the IGFRI/insulin-like growth factor 1 (IGF-1) autocrine pathway was shown to overrule the catabolic effects of the IL-1/IL-1RI pathway by up-regulation of the IL-1RII decoy receptor...
- Cell death and apoptosis in osteoarthritic cartilage
H A Kim
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, Korea
Curr Drug Targets 8:333-45. 2007
..Because the cardinal feature of OA is a progressive loss of articular cartilage, a great portion of the research endeavour into the pathogenesis of OA has been focused on the regulation ..
- Update on advanced surgical techniques in the treatment of traumatic focal articular cartilage lesions in the knee
Nicholas A Sgaglione
Division of Sports Medicine, North Shore University Hospital, Manhasset, New York, USA
Arthroscopy 18:9-32. 2002
..has been developed over the past several years in expanding the treatment of symptomatic femoral condylar articular cartilage lesions in active patients...
- Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
B C Sondergaard
Nordic Bioscience Diagnostics, Herlev, Denmark
Osteoarthritis Cartilage 14:759-68. 2006
..We investigated direct effects of calcitonin on chondrocytes by assessing expression of the receptor and pharmacological effects on collagen type II degradation under ex vivo and in vivo conditions...
- Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation
D M Salter
Department of Pathology, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
Biorheology 39:97-108. 2002
Mechanical stimulation is critically important for the maintenance of normal articular cartilage integrity. Molecular events regulating responses of chondrocytes to mechanical forces are beginning to be defined...
- Biosynthetic response and mechanical properties of articular cartilage after injurious compression
Anatomisches Institut der CAU Kiel, Germany
J Orthop Res 19:1140-6. 2001
Traumatic joint injury is known to produce osteoarthritic degeneration of articular cartilage. To study the effects of injurious compression on the degradation and repair of cartilage in vitro, we developed a model that allows strain and ..
- Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
Institute of Anatomy, Musculoskeletal Research Group, Ludwig Maximilian University Munich, Pettenkoferstrasse 11, D 80336 Munich
Ann N Y Acad Sci 1095:554-63. 2007
..These findings suggest that this dietary polyphenolic compound may have future applications in the nutraceutical-based therapy of human and animal OA...
- Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane
E B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Switzerland
J Bone Joint Surg Am 78:721-33. 1996
Partial-thickness defects evolving in mature articular cartilage do not heal spontaneously...
- Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes
Department of Biochemistry, Rush Medical College, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA
J Biol Chem 281:17952-60. 2006
..the loss of extracellular matrix proteoglycan and collagen from cultured slices of normal adult human articular cartilage. This loss was coincident with an increased expression of matrix metalloproteinase (MMP)-13...
- Quantitative structural organization of normal adult human articular cartilage
E B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
Osteoarthritis Cartilage 10:564-72. 2002
Data pertaining to the quantitative structural features and organization of normal articular cartilage are of great importance in understanding its biomechanical properties and in attempting to establish this tissue's counterpart by ..
- Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration
University of Erlangen Nurnberg, Erlangen, Germany
Arthritis Rheum 46:1986-96. 2002
- Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T
T J Mosher
Department of Radiology, Center for NMR Research, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey 17033, USA
Radiology 214:259-66. 2000
..To determine if age and early symptomatic degeneration alter the spatial dependency of cartilage T2...
- Age-related changes in the morphology and deformational behavior of knee joint cartilage
, Munich, Germany
Arthritis Rheum 44:2556-61. 2001
..We show that under in vivo loading conditions, elderly subjects display a lower level of cartilage deformation than do healthy young subjects...
- Treatment of focal articular cartilage defects in the knee: a systematic review
Robert A Magnussen
Vanderbilt Orthopaedic Institute, 4200 Medical Center East, 1215 21st Avenue South, Suite 4200, Nashville, TN, 37232 8774, USA
Clin Orthop Relat Res 466:952-62. 2008
..outcomes compared with one another or with traditional abrasive techniques for treatment of isolated articular cartilage defects and whether lesion size influences this clinical outcome...
- Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis
Division of Orthopedic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, USA
J Rheumatol 28:1311-8. 2001
..coherence tomography (OCT), a new method of high resolution imaging, has shown feasibility for assessing articular cartilage to identify early changes in osteoarthritis (OA) and monitor therapy...
- Joint diseases and matrix metalloproteinases: a role for MMP-13
Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
Curr Pharm Biotechnol 9:47-54. 2008
..This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis...
- Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis
David D Frisbie
Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
Am J Vet Res 68:290-6. 2007
..To assess the clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum (ACS) in the treatment of experimentally induced osteoarthritis in horses...
- Osteoarthritis cartilage histopathology: grading and staging
K P H Pritzker
Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
Osteoarthritis Cartilage 14:13-29. 2006
..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
- Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo
C De Bari
University Hospitals Katholieke Universiteit Leuven, Belgium
Arthritis Rheum 44:1608-19. 2001
..This cartilage-forming ability in vivo may be pivotal for successful cell-based joint surface defect repair protocols...
- Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes
V I Grishko
Department of Cell Biology, University of South Alabama, Mobile, AL 36688 0002, USA
Osteoarthritis Cartilage 17:107-13. 2009
..The aim of this study was to determine whether mtDNA damage was present in OA chondrocytes, and whether mtDNA repair capacity is compromised in OA chondrocytes following oxidative stress, leading to chondrocyte death...
- Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
L A Neuhold
Molecular Genetics Division, Wyeth Ayerst Research, Princeton, New Jersey, USA
J Clin Invest 107:35-44. 2001
..Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA...
- Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes
Laboratory of Investigation, Rheumatology Division, Juan Canalejo Hospital, C Xubias 84, 15006 A Coruna, Spain
Ann Rheum Dis 64:388-95. 2005
..To investigate the effect of nitric oxide (NO) on mitochondrial activity and its relation with the apoptosis of human articular chondrocytes...
- Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
Arthritis Rheum 56:2663-73. 2007
..To investigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis of osteoarthritis (OA)...
- Basic FGF mediates an immediate response of articular cartilage to mechanical injury
The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, 1 Aspenlea Road, London W6 8LH, UK
Proc Natl Acad Sci U S A 99:8259-64. 2002
..ERK), one of the three types of mitogen-activated kinases, was rapidly activated after cutting porcine articular cartilage either when maintained as explants or in situ...
- Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells
Department of Oro Maxillo Facial Surgery, University of Erlangen Nuernberg, Germany
J Gene Med 8:112-25. 2006
Adult primary mesenchymal cells of different origin which can be obtained with minor donor site morbidity are considered for articular cartilage repair. This study aims at a comparison of their chondrogenic potential.
- Site-specific effects of compression on macromolecular diffusion in articular cartilage
Holly A Leddy
Department of Surgery and Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710, USA
Biophys J 95:4890-5. 2008
b>Articular cartilage is the connective tissue that lines joints and provides a smooth surface for joint motion...
- A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage
S D Waldman
Department of Mechanical and Materials Engineering, Queen s University, Kingston, Ontario, Canada
Osteoarthritis Cartilage 14:323-30. 2006
..Thus, the purpose of this study was to investigate the effect of a single application of cyclic loading to chondrocytes on the formation and properties of in vitro-formed tissue...
- Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, W6 8LH, UK
J Biol Chem 279:43514-21. 2004
We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry...