- Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
Mary B Goldring
The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
Ann N Y Acad Sci 1192:230-7. 2010
..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
- An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
Botnar Research Centre, University of Oxford, UK
Hum Mol Genet 16:2226-32. 2007
..A small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to OA...
- Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis
Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Brownlow Hill and Crown Street, Liverpool, L69 7ZJ UK
Med Hypotheses 58:193-7. 2002
..This understanding is essential for developing appropriately targeted anti-protease therapies for the inhibition of chondrocyte apoptosis in the rational treatment of osteoarthritis...
- The role of reactive oxygen species in homeostasis and degradation of cartilage
Y E Henrotin
Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
Osteoarthritis Cartilage 11:747-55. 2003
..ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable...
- Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage
Division of Arthritis Research MEM 161, The Scripps Research Institute, La Jolla, CA 92037, USA
Arthritis Rheum 50:1522-32. 2004
To determine the presence of mesenchymal progenitor cells (MPCs) in human articular cartilage.
- Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho)
Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 48:2509-18. 2003
..of type XI collagen (Col11a1) in mice (chondrodysplasia, cho) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mutation on articular cartilage in knee and temporomandibular (TM) joints.
- TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Cell Biol 153:35-46. 2001
..Unlike most cartilage, articular cartilage is arrested before terminal hypertrophic differentiation...
- The subchondral bone in articular cartilage repair: current problems in the surgical management
Andreas H Gomoll
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the ..
- Calcification of articular cartilage in human osteoarthritis
Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
Arthritis Rheum 60:2694-703. 2009
..The aim of this study was to determine the prevalence and composition of calcium crystals in human OA and analyze their relationship to disease severity and markers of chondrocyte hypertrophy...
- Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
Barts and the London School of Medicine and Dentistry, London, UK
Arthritis Rheum 58:1410-21. 2008
To characterize the molecular response of adult human articular cartilage to acute mechanical injury.
- Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
E B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, Switzerland
Osteoarthritis Cartilage 10:432-63. 2002
To review the basic scientific status of repair in articular cartilage tissue and to assess the efficiency of current clinical therapies instigated for the treatment of structural lesions generated therein as a result of trauma or during ..
- Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
Bone 38:234-43. 2006
..Using a modified Mankin scoring system, we demonstrate that articular cartilage damage occurs within 2 weeks post-surgery in both surgical models...
- Boundary lubrication of articular cartilage: role of synovial fluid constituents
Tannin A Schmidt
University of California, San Diego, La Jolla, CA 92093, USA
Arthritis Rheum 56:882-91. 2007
..the synovial fluid (SF) constituents hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPL) contribute to boundary lubrication, either independently or additively, at an articular cartilage-cartilage interface.
- Articular cartilage: injury pathways and treatment options
Timothy M Simon
Orthopaedic Research Institute and the Southern California Center for Sports Medicine, Long Beach, CA 90806, USA
Sports Med Arthrosc 14:146-54. 2006
b>Articular cartilage injury and degeneration is a frequent occurrence in synovial joints...
- Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage
M J Nissi
Department of Applied Physics, University of Kuopio, and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
J Orthop Res 22:557-64. 2004
..imaging (MRI) techniques have earlier been developed to characterize the structure and composition of articular cartilage. Particularly, Gd-DTPA(2-)-enhanced T1 imaging is sensitive to cartilage proteoglycan content, while T2 ..
- ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
Queensland University of Technology, Brisbane, Queensland, Australia
Arthritis Rheum 62:1349-60. 2010
Previous studies have shown the influence of subchondral bone osteoblasts (SBOs) on phenotypical changes of articular cartilage chondrocytes (ACCs) during the development of osteoarthritis (OA)...
- Major biological obstacles for persistent cell-based regeneration of articular cartilage
Andre F Steinert
Orthopaedic Center for Musculoskeletal Research, König Ludwig Haus, Julius Maximilians University, Wurzburg, Germany
Arthritis Res Ther 9:213. 2007
Hyaline articular cartilage, the load-bearing tissue of the joint, has very limited repair and regeneration capacities...
- Quantitative structural organization of normal adult human articular cartilage
E B Hunziker
M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
Osteoarthritis Cartilage 10:564-72. 2002
Data pertaining to the quantitative structural features and organization of normal articular cartilage are of great importance in understanding its biomechanical properties and in attempting to establish this tissue's counterpart by ..
- Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction
Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA 95817, USA
Arthritis Rheum 60:2333-9. 2009
b>Articular cartilage is an avascular tissue with precise polarity and organization comprising 3 distinct functional zones: the surface, middle, and deep zones...
- Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging
S K de Visser
School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
Osteoarthritis Cartilage 16:83-9. 2008
To demonstrate the use of diffusion tensor magnetic resonance micro-imaging to observe adaptations of collagen fibres to mechanical compression in articular cartilage.
- Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes
L C Tetlow
University Department of Medicine, Manchester Royal Infirmary, The University of Manchester, UK
Arthritis Rheum 44:585-94. 2001
..tumor necrosis factor alpha (TNFalpha) in osteoarthritic (OA) cartilage compared with normal, age-matched articular cartilage. METHODS: Articular cartilage samples were obtained from the tibial plateau of OA knees removed at ..
- Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage
Division of Rheumatology, Institut de Recherches Servier, Suresnes, France
Biochem Biophys Res Commun 267:438-44. 2000
..degradation, matrix-metalloproteinase (MMP) expression and activity, and chondrocyte apoptosis in rabbit articular cartilage. Cell-permeant ceramide C(2) stimulated proteoglycan degradation in cartilage explants starting from 3 x 10(..
- Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology
Emma J Blain
Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, UK
Int J Exp Pathol 90:1-15. 2009
..review will primarily focus on the organization and function of the three major cytoskeletal networks in articular cartilage chondrocytes...
- Rapid phenotypic changes in passaged articular chondrocyte subpopulations
Eric M Darling
Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
J Orthop Res 23:425-32. 2005
Articular chondrocytes are often expanded in vitro and then used to assist in healing articular cartilage defects...
- Strategies for articular cartilage lesion repair and functional restoration
Tamer A E Ahmed
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Tissue Eng Part B Rev 16:305-29. 2010
Injury of articular cartilage due to trauma or pathological conditions is the major cause of disability worldwide, especially in North America...
- Characterization of metalloprotease cleavage products of human articular cartilage
Eugene Y Zhen
Eli Lilly and Company, Greenfield, IN 46140, USA
Arthritis Rheum 58:2420-31. 2008
To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage.
- Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
Imperial College London, London, UK
Arthritis Rheum 58:3498-509. 2008
Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage.
- The surface of articular cartilage contains a progenitor cell population
Gary P Dowthwaite
Cardiff School of Biosciences and Cardiff Institute of Tissue Engineering and Repair, Cardiff University, PO Box 911, Museum Avenue, Cardiff CF10 3US, UK
J Cell Sci 117:889-97. 2004
It is becoming increasingly apparent that articular cartilage growth is achieved by apposition from the articular surface...
- Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports
Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
Cell Transplant 13:595-600. 2004
..the effectiveness of autologous bone marrow stromal cell transplantation for the repair of full-thickness articular cartilage defects in the patellae of a 26-year-old female and a 44-year-old male...
- Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage
Paul J Fanning
Massachusetts General Hospital, Orthopaedic Research Laboratories, and Harvard Medical School, Boston, Massachusetts, USA
J Biol Chem 278:50940-8. 2003
..Finally, the data indicate that compression coactivates distinct signaling pathways that may help define the nature of mechanotransduction in cartilage...
- Tissue engineering of stratified articular cartilage from chondrocyte subpopulations
T J Klein
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
Osteoarthritis Cartilage 11:595-602. 2003
..Constructs were cultured for 1 or 2 weeks and were assessed for growth, compressive properties, and deposition, and localization of matrix molecules and superficial zone protein (SZP)...
- Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
Osteoarthritis Cartilage 15:226-31. 2007
..This study assessed the effectiveness of autologous bone-marrow stromal cells, which were embedded within a collagen scaffold, to repair a full-thickness articular cartilage defect in the medial femoral condyle of an athlete.
- Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
J Tissue Eng Regen Med 1:74-9. 2007
..the effectiveness of autologous culture-expanded bone marrow mesenchymal cell transplantation for repairing articular cartilage defects, we transplanted autologous culture-expanded bone marrow mesenchymal cells into nine full-thickness ..
- Basic science of articular cartilage and osteoarthritis
Andrew D Pearle
Shoulder and Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
Clin Sports Med 24:1-12. 2005
b>Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface...
- Articular cartilage: structure, injuries and review of management
Abhijit M Bhosale
Institute of Orthopaedics and Arthritis Research Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, UK
Br Med Bull 87:77-95. 2008
Chondral and osteochondral injuries are commonly seen in today's clinical practice. Articular cartilage provides an ultimate low-friction gliding surface, which none of the artificial constructs have been able to replace successfully...
- Current strategies for articular cartilage repair
S N Redman
CITER, Cardiff School of Biosciences, Museum Avenue, Cardiff, CF10 3US, Wales, UK
Eur Cell Mater 9:23-32; discussion 23-32. 2005
Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal spontaneously...
- Osteoarthritis and cartilage: the role of cytokines
M B Goldring
Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Room 246, 4 Blackfan Circle, Boston, MA 02115, USA
Curr Rheumatol Rep 2:459-65. 2000
..biochemical, and genetic factors that contribute to the imbalance in the synthesis and destruction of articular cartilage. It is now well documented that interleukin-1 and tumor necrosis factor-alpha are the predominant ..
- Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes
University Hospital, Basel, Switzerland
Arthritis Rheum 48:1315-25. 2003
- Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis
D A Walsh
Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Osteoarthritis Cartilage 15:743-51. 2007
..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA...
- Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB
Division of Arthritis Research, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 273:27467-73. 1998
..These results suggest that IL-17 activation of chondrocytes is associated with and depends at least in part on the activation of MAP kinases and NF-kappaB...
- Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics
Department of Physics, University of Kuopio, Kuopio, Finland
Osteoarthritis Cartilage 18:73-81. 2010
Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e...
- The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage
Orthopaedic Research Laboratories, Department of Surgery, Division of Orthopaedic Surgery, 375 MSRB, Box 3093, Duke University Medical Center, Durham, NC 27710, USA
Ann N Y Acad Sci 1068:498-512. 2006
The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular cartilage, which together with the enclosed cell(s) has been termed the "chondron...
- Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study
Oxford University, Oxford, UK
Arthritis Rheum 50:3915-24. 2004
..information on the gradients of oxygen concentration from the synovial surface to the subchondral bone in articular cartilage. Cartilage is usually regarded as hypoxic, even though cellular metabolism is inhibited at low oxygen ..
- A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
D D Frisbie
Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
Vet Comp Orthop Traumatol 19:142-6. 2006
..on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee...
- The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Arthritis Rheum 50:1193-206. 2004
- Mechanisms for asporin function and regulation in articular cartilage
Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 282:32185-92. 2007
..OA is characterized by the loss of articular cartilage; however, the details of its etiology and pathogenesis remain unclear...
- Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis
C G Peterfy
Synarc, Inc, San Francisco, CA 94105, USA
Osteoarthritis Cartilage 12:177-90. 2004
..To determine the inter-observer agreement of this scoring method. To examine associations among the features included in the scoring method...
- Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
Osteoarthritis Cartilage 14:545-53. 2006
..To investigate the effect of l-glutamine (Gln) on stress responses of chondrocytes exposed to heat stress or nitric oxide (NO)...
- The role of cytokines in osteoarthritis pathophysiology
Julio C Fernandes
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Biorheology 39:237-46. 2002
..Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression...
- Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
P M van der Kraan
Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Osteoarthritis Cartilage 18:735-41. 2010
..Although BMPs are considered protective for articular cartilage these factors can also be involved in chondrocyte hypertrophy and matrix degradation...
- Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants
C A M Huser
University of Cambridge, Cambridge, UK
Arthritis Rheum 56:2322-34. 2007
..This study aimed to elucidate the mechanisms involved upstream of caspase 9 activation and, in particular, calcium signaling and mitochondrial depolarization...
- DT-MRI based computation of collagen fiber deformation in human articular cartilage: a feasibility study
David M Pierce
Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, Kronesgasse 5 I, Graz, Austria
Ann Biomed Eng 38:2447-63. 2010
..To model the complex morphology and response of articular cartilage, a hyperviscoelastic (dispersed) fiber-reinforced constitutive model is employed to complete two specimen-..
- Quantitative assessment of articular cartilage morphology via EPIC-microCT
George W Woodruff School of Mechanical Engineering, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0405, United States
Osteoarthritis Cartilage 17:313-20. 2009
..The objective of the present study was to validate the ability of Equilibrium Partitioning of an Ionic Contrast agent via microcomputed tomography (EPIC-microCT) to nondestructively assess cartilage morphology in the rat model...
- Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture, and osteochondral autograft transplantation
Orthopaedic Arthroscopic Surgery International, Milan, Italy
Arthroscopy 22:1085-92. 2006
..The purpose of this study was to compare outcomes of chondroplasty versus microfracture versus osteochondral autologous transplantation (OAT) in patients with osteochondral lesions of the talus (OLT)...
- Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis
INSERM U606, Universite Paris 7, Paris, France
Arthritis Rheum 58:2379-86. 2008
..To characterize bone microarchitectural changes and to test the hypothesis that disrupting local cytokine equilibrium could modify cartilage degradation in a murine model of experimental osteoarthritis (OA)...
- Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging
Miika T Nieminen
Department of Anatomy, University of Kuopio, Finland
Magn Reson Med 48:640-8. 2002
In Gd-DTPA-enhanced T(1) imaging of articular cartilage, the MRI contrast agent with two negative charges is understood to accumulate in tissue inversely to the negative charge of cartilage glycosaminoglycans (GAGs) of proteoglycans (PGs)..
- ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
Lisa A Collins-Racie
Department of Discovery Medicine, Wyeth Research, Cambridge, MA 02140, USA
Matrix Biol 23:219-30. 2004
..proteoglycan aggrecan, and ADAMTS-4 and ADAMTS-5 have been postulated to play a role in the depletion of articular cartilage in osteoarthritic disease...
- Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T2* mapping
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States
Osteoarthritis Cartilage 18:539-46. 2010
To examine the sensitivity of ultra-short echo time (UTE) T(2)* mapping to collagen matrix degeneration in human articular cartilage.
- Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice
Shriners Hospital for Children and McGill University, Montreal, Quebec, Canada
Arthritis Rheum 56:905-9. 2007
To investigate the in vivo effect of an imbalance between metalloproteinases and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in mouse articular cartilage.
- 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects
Ravinder Reddy Regatte
Metabolic Magnetic Resonance Resource and Computing Center MMRRCC, Department of Radiology, B1, Stellar Chance Laboratories, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6100, USA
Acad Radiol 11:741-9. 2004
..To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI)...
- Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China
Institute of Endemic Diseases, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, PR China
Osteoarthritis Cartilage 16:680-8. 2008
..5 million of 30 million people living in the KBD regions of China...
- Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
Kennedy Institute of Rheumatology, Hammersmith, London, U K
Biochem J 313:933-40. 1996
The content of the C-terminal region of aggrecan was investigated in samples of articular cartilage from individuals ranging in age from newborn to 65 years...
- Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure
Department of Clinical Neurophysiology, Kuopio University Hospital, POB 1777, FI 70211, Kuopio, Finland
J Biomech 41:1978-86. 2008
Mechanical properties of articular cartilage are controlled by tissue composition and structure. Cartilage function is sensitively altered during tissue degeneration, in osteoarthritis (OA)...
- Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
S J Gilbert
Cardiff University, Cardiff, Wales, UK
Arthritis Rheum 58:209-20. 2008
..proinflammatory cytokine signaling, induces cartilage degradation and reduces type II collagen synthesis in articular cartilage. The accumulation of ceramide is associated with arthritis in Farber's disease...
- Characterization of mature vs aged rabbit articular cartilage: analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis
R Todd Allen
Department of Orthopaedic Surgery, University of California San Diego, La Jolla, CA 92093 0630, USA
Osteoarthritis Cartilage 12:917-23. 2004
..To address the question of whether age predisposes articular cartilage to apoptosis, the objective of the present study was to characterize and compare in aged and mature non-OA ..
- T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study
M T Nieminen
Department of Anatomy, University of Kuopio, Kuopio, Finland
Magn Reson Med 46:487-93. 2001
It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise T2 anisotropy of MRI through the magic angle effect...
- Sulfation of chondroitin sulfate in human articular cartilage. The effect of age, topographical position, and zone of cartilage on tissue composition
M T Bayliss
Royal Veterinary College, Royal College Street, London NW1 OTU, United Kingdom
J Biol Chem 274:15892-900. 1999
The chondroitin ABC lyase digestion products of normal human femoral condyle articular cartilage and of purified aggrecan were analyzed for their mono- and nonsulfated disaccharide composition...
- The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope study and review
L C Hughes
The University of Wales Bioimaging Laboratory, Institute of Biological Sciences, Aberystwyth, Wales, UK
Eur Cell Mater 9:68-84. 2005
Adult mouse articular cartilage (AC) has not been thoroughly described using high resolution imaging techniques, despite the fact that the availability of knockout mice with specific extracellular matrix (ECM) mutations have renewed ..
Mary B Goldring
Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
J Cell Physiol 213:626-34. 2007
Osteoarthritis (OA) is characterized by degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and changes in peri-articular and subchondral bone...
- Management of articular cartilage defects of the knee
Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
J Bone Joint Surg Am 92:994-1009. 2010
b>Articular cartilage has a poor intrinsic capacity for healing. The goal of surgical techniques to repair articular cartilage injuries is to achieve the regeneration of organized hyaline cartilage...
- A three-dimensional osteochondral composite scaffold for articular cartilage repair
Jill K Sherwood
Therics, Inc, 115 Campus Drive, Princeton, NJ 08540, USA
Biomaterials 23:4739-51. 2002
There is a recognized and urgent need for improved treatment of articular cartilage defects...
- Repair of large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into beta-tricalcium phosphate in a sheep model
Institute of Basic Medical Sciences of Beijing, Beijing, People s Republic of China
Tissue Eng 10:1818-29. 2004
Tissue engineering has long been investigated to repair articular cartilage defects. Successful reports have usually involved the seeding of autologous chondrocytes into polymers...
- Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
Severe joint inflammation following trauma, arthroscopic surgery or infection can damage articular cartilage, thus every effort should be made to protect cartilage from the catabolic effects of pro-inflammatory cytokines and stimulate ..
- Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions
Elena V Tchetina
Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada
J Rheumatol 32:876-86. 2005
b>Articular cartilage degeneration in osteoarthritis (OA) involves excessive degradation of extracellular matrix (ECM) and chondrocyte differentiation (hypertrophy)...
- Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging
Miika T Nieminen
Department of Anatomy, University of Kuopio, Kuopio, Finland
J Biomech 37:321-8. 2004
..MRI) is the most potential non-invasive means for revealing the structure, composition and pathology of articular cartilage. Here we hypothesize that cartilage mechanical properties as determined by the macromolecular framework and ..
- Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
L A Neuhold
Molecular Genetics Division, Wyeth Ayerst Research, Princeton, New Jersey, USA
J Clin Invest 107:35-44. 2001
..Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA...
- Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis
L A Collins-Racie
Department of Biological Technologies, Cambridge, MA 02140, USA
Osteoarthritis Cartilage 17:832-42. 2009
Compare the expression and regulation of nuclear receptors (NRs) in osteoarthritic and normal human articular cartilage.
- Osteophytes: relevance and biology
Peter M van der Kraan
Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
Osteoarthritis Cartilage 15:237-44. 2007
..Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes...
- Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique
T B F Woodfield
Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
Biomaterials 25:4149-61. 2004
..PEGT/PBT) block co-polymer scaffolds with a 100% interconnecting pore network for engineering of articular cartilage. The technique allowed us to "design-in" desired scaffold characteristics layer by layer by accurately ..
- New techniques in articular cartilage imaging
Hollis G Potter
Magnetic Resonance Imaging, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
Clin Sports Med 28:77-94. 2009
..MRI provides an essential objective assessment of cartilage regenerative procedures...
- Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants
Department of Traumatology and Orthopaedic Surgery, University of Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
J Orthop Res 27:1353-60. 2009
..and hyaluronan were immersed in autologous serum and used for covering microfractured full-thickness articular cartilage defects of the sheep (n = 4). Defects treated with microfracture only served as controls (n = 4)...
- The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions
Laboratory for Biomechanics, Swiss Federal Institute of Technology Zurich ETHZ, CH 8952 Schlieren, Switzerland
Osteoarthritis Cartilage 10:408-19. 2002
The purpose of this paper is to review current data and concepts concerning the effect of immobilization on articular cartilage in animal models. We also evaluate the methods to measure articular cartilage changes in humans.
- Characterization of articular cartilage by combining microscopic analysis with a fibril-reinforced finite-element model
Department of Physics, University of Kuopio, Kuopio, Finland
J Biomech 40:1862-70. 2007
Load-bearing characteristics of articular cartilage are impaired during tissue degeneration...
- In vitro stimulation of equine articular cartilage proteoglycan synthesis by hyaluronan and carprofen
S P Frean
Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
Res Vet Sci 67:183-90. 1999
- Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
Allan A Young
Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia
Arthritis Res Ther 7:R852-61. 2005
..form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage. Along with increased production and activation of degradative enzymes, altered synthesis of cartilage ..
- Meniscal allograft transplantation--part II: alternative treatments, effects on articular cartilage, and future directions
Paul C Rijk
Department of Orthopaedic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
Arthroscopy 20:851-9. 2004
..allograft transplantation are evaluated as well as the effect of meniscal allograft transplantation on articular cartilage. Remaining questions and future directions are considered in a final discussion...
- Extraction techniques for the decellularization of tissue engineered articular cartilage constructs
Benjamin D Elder
Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
Biomaterials 30:3749-56. 2009
..However, limited work has been performed with articular cartilage, and no studies have examined the decellularization of tissue engineered constructs...
- The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results
Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey
Arthroscopy 24:1214-20. 2008
The purpose of this study was to determine the effectiveness of the microfracture technique in the treatment of full-thickness articular cartilage lesions of the knee.
- Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
Arthroscopic Surgery Unit, USP La Esperanza Clinic, Vitoria Gasteiz, Basque Country, Spain
Med Sci Sports Exerc 35:1648-52. 2003
..This is attributed to the slow delivery of growth factors from harvested platelets that have been activated by endogenous thrombin promoted by the addition of calcium chloride...
- Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation
Institute of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland
Osteoarthritis Cartilage 17:448-55. 2009
..The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs...
- Outcomes of full-thickness articular cartilage injuries of the shoulder treated with microfracture
Peter J Millett
Steadman Hawkins Clinic and Steadman Hawkins Research Foundation, Vail, CO 81657, USA
Arthroscopy 25:856-63. 2009
..The purpose of this study was to determine whether microfracture provides pain relief and improves shoulder function in patients with chondral defects of the glenohumeral joint...
- Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques
Cartilage Repair Center, Brigham and Women s Hospital, Harvard Medical School, 850 Boylston Street, Chestnut Hill, MA 02467, USA
Am J Sports Med 37:902-8. 2009
..Common knowledge holds that these treatments do not compromise subsequent cartilage repair procedures with autologous chondrocyte implantation...
- A clinical review of cartilage repair techniques
G D Smith
Robert Jones and Agnes Hunt Orthopaedic Hospital, Gobowen, Oswestry, Shropshire SY10 7AG, England, UK
J Bone Joint Surg Br 87:445-9. 2005
- Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity
Department of Plastic Surgery, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
Osteoarthritis Cartilage 13:614-22. 2005
..To test the hypothesis that age-related loss of chondrocytes in cartilage is associated with impaired reactive oxygen species (ROS) homeostasis resulting from reduced antioxidant defence...
- The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage
Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Eindhoven 5600 MB, The Netherlands
Med Eng Phys 27:810-26. 2005
b>Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis degeneration of articular cartilage occurs...
- Morphology and phenotype expression of types I, II, III, and X collagen and MMP-13 of chondrocytes cultured from articular cartilage of Kashin-Beck Disease
Department of Orthopedics Surgery, Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
J Rheumatol 35:696-702. 2008
..expression of types I, II, III, and X collagen and matrix metalloproteinase-13 (MMP-13) of chondrocytes from articular cartilage of adult patients with Kashin-Beck Disease (KBD) in vitro to understand the pathogenesis in chondrocytes.
- Aging, articular cartilage chondrocyte senescence and osteoarthritis
James A Martin
Department of Orthopaedics, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Biogerontology 3:257-64. 2002
..of osteoarthritis (OA), the disease characterized by joint pain and loss of joint form and function due to articular cartilage degeneration, is directly correlated with age...
- Sensitivities of medial meniscal motion and deformation to material properties of articular cartilage, meniscus and meniscal attachments using design of experiments methods
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA
J Biomech Eng 128:399-408. 2006
This study investigated the role of the material properties assumed for articular cartilage, meniscus and meniscal attachments on the fit of a finite element model (FEM) to experimental data for meniscal motion and deformation due to an ..
- The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage
Orthopaedic Research Laboratories, Departments of Surgery, Biomedical Engineering, and Mechanical Engineering and Materials Science, Duke University Medical Center, P O Box 3093, 375 MSRB, 27710, Durham, NC, USA
J Biomech 33:1663-73. 2000
..Based on the existing experimental data on the deformation behavior and biomechanical properties of articular cartilage and chondrocytes, a multi-scale biphasic finite element model was developed of the chondrocyte as a ..
- Prospective evaluation of concurrent meniscus transplantation and articular cartilage repair: minimum 2-year follow-up
John Paul H Rue
Department of Orthopaedic Surgery, National Naval Medical Center, Bethesda, Maryland, USA
Am J Sports Med 36:1770-8. 2008
Recognition of the symbiotic relationship between the meniscus and articular cartilage is critical to the success of meniscal allograft transplantation...
- Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage
Gaubius Laboratory, TNO Prevention and Health, 2301 CE Leiden, The Netherlands
Osteoarthritis Cartilage 9:720-6. 2001
..OAs) increases with age and coincides with the accumulation of advanced glycation endproducts (AGEs) in articular cartilage, suggesting that accumulation of glycation products may be involved in the development of OA...