articular cartilage

Summary

Top Publications

  1. doi Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    Mary B Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann N Y Acad Sci 1192:230-7. 2010
  2. pmc The subchondral bone in articular cartilage repair: current problems in the surgical management
    Andreas H Gomoll
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
    Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
  3. ncbi The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
  4. ncbi An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
  5. ncbi Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Tadashi Hayami
    Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
    Bone 38:234-43. 2006
  6. ncbi Osteoarthritis
    Mary B Goldring
    Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
    J Cell Physiol 213:626-34. 2007
  7. ncbi Strategies for articular cartilage lesion repair and functional restoration
    Tamer A E Ahmed
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Tissue Eng Part B Rev 16:305-29. 2010
  8. ncbi Characterization of metalloprotease cleavage products of human articular cartilage
    Eugene Y Zhen
    Eli Lilly and Company, Greenfield, IN 46140, USA
    Arthritis Rheum 58:2420-31. 2008
  9. doi Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
    Yasunobu Sawaji
    Imperial College London, London, UK
    Arthritis Rheum 58:3498-509. 2008
  10. ncbi Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells
    R Kuroda
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
    Osteoarthritis Cartilage 15:226-31. 2007

Detail Information

Publications363 found, 100 shown here

  1. doi Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    Mary B Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann N Y Acad Sci 1192:230-7. 2010
    ..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
  2. pmc The subchondral bone in articular cartilage repair: current problems in the surgical management
    Andreas H Gomoll
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
    Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
    As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the ..
  3. ncbi The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
    ..Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression...
  4. ncbi An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
    ..A small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to OA...
  5. ncbi Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Tadashi Hayami
    Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
    Bone 38:234-43. 2006
    ..Using a modified Mankin scoring system, we demonstrate that articular cartilage damage occurs within 2 weeks post-surgery in both surgical models...
  6. ncbi Osteoarthritis
    Mary B Goldring
    Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
    J Cell Physiol 213:626-34. 2007
    Osteoarthritis (OA) is characterized by degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and changes in peri-articular and subchondral bone...
  7. ncbi Strategies for articular cartilage lesion repair and functional restoration
    Tamer A E Ahmed
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Tissue Eng Part B Rev 16:305-29. 2010
    Injury of articular cartilage due to trauma or pathological conditions is the major cause of disability worldwide, especially in North America...
  8. ncbi Characterization of metalloprotease cleavage products of human articular cartilage
    Eugene Y Zhen
    Eli Lilly and Company, Greenfield, IN 46140, USA
    Arthritis Rheum 58:2420-31. 2008
    To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage.
  9. doi Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
    Yasunobu Sawaji
    Imperial College London, London, UK
    Arthritis Rheum 58:3498-509. 2008
    Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage.
  10. ncbi Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells
    R Kuroda
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
    Osteoarthritis Cartilage 15:226-31. 2007
    ..This study assessed the effectiveness of autologous bone-marrow stromal cells, which were embedded within a collagen scaffold, to repair a full-thickness articular cartilage defect in the medial femoral condyle of an athlete.
  11. ncbi Tissue engineering of stratified articular cartilage from chondrocyte subpopulations
    T J Klein
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Osteoarthritis Cartilage 11:595-602. 2003
    ..Constructs were cultured for 1 or 2 weeks and were assessed for growth, compressive properties, and deposition, and localization of matrix molecules and superficial zone protein (SZP)...
  12. ncbi Articular cartilage and osteoarthritis
    Joseph A Buckwalter
    Department of Orthopaedics, University of Iowa, Iowa City, USA
    Instr Course Lect 54:465-80. 2005
    b>Articular cartilage, which makes possible the painless, low-friction movement of synovial joints, consists of a sparsely distributed population of highly specialized cells called chondrocytes that are embedded within a matrix and provide ..
  13. doi Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics
    S Saarakkala
    Department of Physics, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 18:73-81. 2010
    Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e...
  14. ncbi The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage
    Farshid Guilak
    Orthopaedic Research Laboratories, Department of Surgery, Division of Orthopaedic Surgery, 375 MSRB, Box 3093, Duke University Medical Center, Durham, NC 27710, USA
    Ann N Y Acad Sci 1068:498-512. 2006
    The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular cartilage, which together with the enclosed cell(s) has been termed the "chondron...
  15. ncbi Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study
    Shengda Zhou
    Oxford University, Oxford, UK
    Arthritis Rheum 50:3915-24. 2004
    ..information on the gradients of oxygen concentration from the synovial surface to the subchondral bone in articular cartilage. Cartilage is usually regarded as hypoxic, even though cellular metabolism is inhibited at low oxygen ..
  16. ncbi A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
    D D Frisbie
    Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
    Vet Comp Orthop Traumatol 19:142-6. 2006
    ..on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee...
  17. ncbi Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis
    C G Peterfy
    Synarc, Inc, San Francisco, CA 94105, USA
    Osteoarthritis Cartilage 12:177-90. 2004
    ..To determine the inter-observer agreement of this scoring method. To examine associations among the features included in the scoring method...
  18. ncbi Mechanisms for asporin function and regulation in articular cartilage
    Masahiro Nakajima
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:32185-92. 2007
    ..OA is characterized by the loss of articular cartilage; however, the details of its etiology and pathogenesis remain unclear...
  19. ncbi The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
    Tadashi Hayami
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Arthritis Rheum 50:1193-206. 2004
    ....
  20. doi Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
    Francesco Dell'accio
    Barts and the London School of Medicine and Dentistry, London, UK
    Arthritis Rheum 58:1410-21. 2008
    To characterize the molecular response of adult human articular cartilage to acute mechanical injury.
  21. ncbi Rapid phenotypic changes in passaged articular chondrocyte subpopulations
    Eric M Darling
    Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
    J Orthop Res 23:425-32. 2005
    Articular chondrocytes are often expanded in vitro and then used to assist in healing articular cartilage defects...
  22. pmc Extraction techniques for the decellularization of tissue engineered articular cartilage constructs
    Benjamin D Elder
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Biomaterials 30:3749-56. 2009
    ..However, limited work has been performed with articular cartilage, and no studies have examined the decellularization of tissue engineered constructs...
  23. ncbi Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage
    J DeGroot
    Gaubius Laboratory, TNO Prevention and Health, 2301 CE Leiden, The Netherlands
    Osteoarthritis Cartilage 9:720-6. 2001
    ..OAs) increases with age and coincides with the accumulation of advanced glycation endproducts (AGEs) in articular cartilage, suggesting that accumulation of glycation products may be involved in the development of OA...
  24. doi Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques
    Tom Minas
    Cartilage Repair Center, Brigham and Women s Hospital, Harvard Medical School, 850 Boylston Street, Chestnut Hill, MA 02467, USA
    Am J Sports Med 37:902-8. 2009
    ..Common knowledge holds that these treatments do not compromise subsequent cartilage repair procedures with autologous chondrocyte implantation...
  25. ncbi Aging, articular cartilage chondrocyte senescence and osteoarthritis
    James A Martin
    Department of Orthopaedics, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biogerontology 3:257-64. 2002
    ..of osteoarthritis (OA), the disease characterized by joint pain and loss of joint form and function due to articular cartilage degeneration, is directly correlated with age...
  26. pmc Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
    Allan A Young
    Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia
    Arthritis Res Ther 7:R852-61. 2005
    ..form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage. Along with increased production and activation of degradative enzymes, altered synthesis of cartilage ..
  27. ncbi Meniscal allograft transplantation--part II: alternative treatments, effects on articular cartilage, and future directions
    Paul C Rijk
    Department of Orthopaedic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Arthroscopy 20:851-9. 2004
    ..allograft transplantation are evaluated as well as the effect of meniscal allograft transplantation on articular cartilage. Remaining questions and future directions are considered in a final discussion...
  28. ncbi Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity
    N Jallali
    Department of Plastic Surgery, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
    Osteoarthritis Cartilage 13:614-22. 2005
    ..To test the hypothesis that age-related loss of chondrocytes in cartilage is associated with impaired reactive oxygen species (ROS) homeostasis resulting from reduced antioxidant defence...
  29. ncbi Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
    Mikel Sanchez
    Arthroscopic Surgery Unit, USP La Esperanza Clinic, Vitoria Gasteiz, Basque Country, Spain
    Med Sci Sports Exerc 35:1648-52. 2003
    ..This is attributed to the slow delivery of growth factors from harvested platelets that have been activated by endogenous thrombin promoted by the addition of calcium chloride...
  30. ncbi Morphology and phenotype expression of types I, II, III, and X collagen and MMP-13 of chondrocytes cultured from articular cartilage of Kashin-Beck Disease
    Weizhuo Wang
    Department of Orthopedics Surgery, Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
    J Rheumatol 35:696-702. 2008
    ..expression of types I, II, III, and X collagen and matrix metalloproteinase-13 (MMP-13) of chondrocytes from articular cartilage of adult patients with Kashin-Beck Disease (KBD) in vitro to understand the pathogenesis in chondrocytes.
  31. ncbi The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results
    Mehmet Asik
    Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey
    Arthroscopy 24:1214-20. 2008
    The purpose of this study was to determine the effectiveness of the microfracture technique in the treatment of full-thickness articular cartilage lesions of the knee.
  32. ncbi Prospective evaluation of concurrent meniscus transplantation and articular cartilage repair: minimum 2-year follow-up
    John Paul H Rue
    Department of Orthopaedic Surgery, National Naval Medical Center, Bethesda, Maryland, USA
    Am J Sports Med 36:1770-8. 2008
    Recognition of the symbiotic relationship between the meniscus and articular cartilage is critical to the success of meniscal allograft transplantation...
  33. ncbi Basic science of articular cartilage and osteoarthritis
    Andrew D Pearle
    Shoulder and Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    Clin Sports Med 24:1-12. 2005
    b>Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface...
  34. ncbi A clinical review of cartilage repair techniques
    G D Smith
    Robert Jones and Agnes Hunt Orthopaedic Hospital, Gobowen, Oswestry, Shropshire SY10 7AG, England, UK
    J Bone Joint Surg Br 87:445-9. 2005
  35. doi Outcomes of full-thickness articular cartilage injuries of the shoulder treated with microfracture
    Peter J Millett
    Steadman Hawkins Clinic and Steadman Hawkins Research Foundation, Vail, CO 81657, USA
    Arthroscopy 25:856-63. 2009
    ..The purpose of this study was to determine whether microfracture provides pain relief and improves shoulder function in patients with chondral defects of the glenohumeral joint...
  36. ncbi The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage
    F Guilak
    Orthopaedic Research Laboratories, Departments of Surgery, Biomedical Engineering, and Mechanical Engineering and Materials Science, Duke University Medical Center, P O Box 3093, 375 MSRB, 27710, Durham, NC, USA
    J Biomech 33:1663-73. 2000
    ..Based on the existing experimental data on the deformation behavior and biomechanical properties of articular cartilage and chondrocytes, a multi-scale biphasic finite element model was developed of the chondrocyte as a ..
  37. ncbi The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage
    W Wilson
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Eindhoven 5600 MB, The Netherlands
    Med Eng Phys 27:810-26. 2005
    b>Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis degeneration of articular cartilage occurs...
  38. doi Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation
    J Rieppo
    Institute of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 17:448-55. 2009
    ..The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs...
  39. doi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
    ..The aim of this study was to determine the prevalence and composition of calcium crystals in human OA and analyze their relationship to disease severity and markers of chondrocyte hypertrophy...
  40. ncbi Sensitivities of medial meniscal motion and deformation to material properties of articular cartilage, meniscus and meniscal attachments using design of experiments methods
    Jiang Yao
    Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA
    J Biomech Eng 128:399-408. 2006
    This study investigated the role of the material properties assumed for articular cartilage, meniscus and meniscal attachments on the fit of a finite element model (FEM) to experimental data for meniscal motion and deformation due to an ..
  41. pmc Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypert
    Elena V Tchetina
    Shriners Hospitals for Children, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
    Arthritis Res Ther 9:R75. 2007
    ..OA) cartilage and is itself capable of downregulating collagen cleavage and hypertrophy in human OA articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with a wide range ..
  42. doi Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
    J H Lee
    Discovery Research, Centocor Research and Development, Radnor, PA 19087, USA
    Osteoarthritis Cartilage 17:613-20. 2009
    ..This study was undertaken to determine if resistin is present in the joint following joint injury and to elucidate the role of resistin in cartilage degradation...
  43. pmc Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
    R I Bolbos
    Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California San Francisco, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 16:1150-9. 2008
    ..To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3Tesla (3T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging...
  44. doi An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee
    Robert J Buck
    StatAnswers Consulting LLC, San Diego, California 92122, USA
    Magn Reson Med 63:680-90. 2010
    ..These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage...
  45. ncbi The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology
    Michael A Adams
    Department of Anatomy, University of Bristol, Bristol, UK
    Matrix Biol 28:384-9. 2009
    Degeneration of intervertebral discs and articular cartilage can cause pain and disability. Risk factors include genetic inheritance and age, but mechanical loading also is important...
  46. pmc Type III collagen, a fibril network modifier in articular cartilage
    Jiann Jiu Wu
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 285:18537-44. 2010
    The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens...
  47. ncbi Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase
    Young Mee Yoon
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:8412-20. 2002
    ..Chondrocytes isolated from rabbit articular cartilage underwent dedifferentiation upon serial monolayer culture with cessation of type II collagen expression and ..
  48. ncbi Regeneration of degenerated articular cartilage after high tibial valgus osteotomy for medial compartmental osteoarthritis of the knee
    Tomihisa Koshino
    Department of Orthopaedic Surgery, Yokohama City University, School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Knee 10:229-36. 2003
    The aim of the current study was to document regeneration of the articular cartilage after correction of varus deformity for osteoarthritis of the knee...
  49. ncbi Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects
    R Shirazi
    Division of Applied Mechanics, Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada
    J Biomech 42:2458-65. 2009
    b>Articular cartilage and its supporting bone functional conditions are tightly coupled as injuries of either adversely affects joint mechanical environment...
  50. ncbi Current strategies for articular cartilage repair
    S N Redman
    CITER, Cardiff School of Biosciences, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Eur Cell Mater 9:23-32; discussion 23-32. 2005
    Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal spontaneously...
  51. doi Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering
    Stephen M Richardson
    Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    J Cell Physiol 222:23-32. 2010
    Defects of load-bearing connective tissues such as articular cartilage and intervertebral disc (IVD) can result from trauma, degenerative, endocrine, or age-related disease...
  52. pmc In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
    X Li
    Musculo skeletal Quantitative Imaging Research, Department of Radiology, University of California at San Francisco, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 15:789-97. 2007
    ..The objective of this study was to determine the ability of MR T1rho (T(1rho)) and T(2) mapping to detect cartilage matrix degeneration between normal and early OA patients...
  53. ncbi Quantitative MR microscopy of enzymatically degraded articular cartilage
    M T Nieminen
    Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland
    Magn Reson Med 43:676-81. 2000
    Structural changes in bovine patellar articular cartilage, induced by component selective enzymatic treatments, were investigated by measuring tissue T(2) relaxation at 9.4 T...
  54. ncbi Osteophytes: relevance and biology
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
    Osteoarthritis Cartilage 15:237-44. 2007
    ..Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes...
  55. pmc Engineering complex tissues
    Antonios G Mikos
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Tissue Eng 12:3307-39. 2006
    ..Anthony Atala offered a clinician's perspective for functional tissue regeneration, and discussed new biomaterials that can be used to develop new regenerative technologies...
  56. ncbi Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage
    F L Wang
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Osteoarthritis Cartilage 8:161-9. 2000
    The purpose of this study was to identify genes that are differentially expressed in normal versus osteoarthritic human articular cartilage as either potential novel therapeutic targets or diagnostic markers of this disease.
  57. ncbi Macroscopic structure of articular cartilage of the tibial plateau: influence of a characteristic matrix architecture on MRI appearance
    Douglas W Goodwin
    Department of Radiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    AJR Am J Roentgenol 182:311-8. 2004
    The purpose of our study was to describe the structural organization of the extracellular matrix of articular cartilage of the tibial plateau and its influence on MRI appearance.
  58. ncbi Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes
    A Mobasheri
    Molecular Pathogenesis and Connective Tissue Research Groups, Faculty of Veterinary Science, University of Liverpool, UK
    Histol Histopathol 20:1327-38. 2005
    b>Articular cartilage is an avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma...
  59. pmc Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
    J Dudhia
    Kennedy Institute of Rheumatology, Hammersmith, London, U K
    Biochem J 313:933-40. 1996
    The content of the C-terminal region of aggrecan was investigated in samples of articular cartilage from individuals ranging in age from newborn to 65 years...
  60. ncbi Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro
    M Jakob
    Department of Surgery, Research Division, University of Basel, Switzerland
    J Cell Biochem 81:368-77. 2001
    ....
  61. doi Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis
    Kai Mithoefer
    Harvard Vanguard Orthopedics and Sports Medicine, Brigham and Women s Faulkner Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Sports Med 37:2053-63. 2009
    Despite the popularity of microfracture as a first-line treatment for articular cartilage defects in the knee, systematic information on its clinical efficacy for articular cartilage repair and long-term improvement of knee function is ..
  62. ncbi Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
    Nicole Verzijl
    TNO Prevention and Health, Leiden, The Netherlands
    Arthritis Rheum 46:114-23. 2002
    ..We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage.
  63. ncbi Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix
    R Dorotka
    Department of Orthopaedic Surgery, Medical School, University of Vienna, Waehringer Guertel 18 20, A 1090 Wien, Austria
    Biomaterials 26:3617-29. 2005
    ..Only the matrices seeded with autologous cells in combination with microfracture were able to facilitate the regeneration of hyaline-like cartilage...
  64. ncbi Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products
    J DeGroot
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Arthritis Rheum 44:2562-71. 2001
    Progressive destruction of articular cartilage is a hallmark of osteoarthritis (OA) and rheumatoid arthritis (RA). Age-related changes in cartilage may influence tissue destruction and thus progression of the disease...
  65. ncbi Articular cartilage defects: study of 25,124 knee arthroscopies
    W Widuchowski
    Department of the Knee Surgery, Arthroscopy and Sports Traumatology of the District Hospital of Traumatology, ul Bytomska 62, 41 940 Piekary Slaskie, Poland
    Knee 14:177-82. 2007
    This retrospective study aimed to provide data on the prevalence, epidemiology and etiology of the knee articular cartilage lesions and describe and estimate, on the ground of a large database, the number of patients who might benefit ..
  66. ncbi Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis
    Jiang Wu
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 56:3675-84. 2007
    To identify potential molecular mediators and biomarkers for osteoarthritis (OA), through comparative proteomic analysis of articular cartilage tissue obtained from normal donors without OA (n = 7) and patients with OA (n = 7).
  67. ncbi Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Tissue Eng Regen Med 1:74-9. 2007
    ..the effectiveness of autologous culture-expanded bone marrow mesenchymal cell transplantation for repairing articular cartilage defects, we transplanted autologous culture-expanded bone marrow mesenchymal cells into nine full-thickness ..
  68. ncbi Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells
    Ryosuke Kuroda
    Children s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthritis Rheum 54:433-42. 2006
    ..study was undertaken to investigate the ability of MDSCs that were retrovirally transduced to express bone morphogenetic protein 4 (BMP-4) to differentiate into chondrocytes in vitro and in vivo and enhance articular cartilage repair.
  69. pmc Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
    Kazuo Yudoh
    Department of Bioregulation, Institute of Medical Science, St, Marianna University, Kawasaki City, Japan
    Arthritis Res Ther 7:R380-91. 2005
    ..Human chondrocytes and articular cartilage explants were isolated from knee joints of patients undergoing arthroplastic knee surgery for OA...
  70. ncbi Knee structural alteration and BMI: a cross-sectional study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Obes Res 13:350-61. 2005
    ..To describe the associations among BMI, knee cartilage morphology, and bone size in adults...
  71. ncbi Animal models of osteoarthritis
    Kenneth D Brandt
    Rheumatology Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biorheology 39:221-35. 2002
    ..an effect, although diacerhein and glucosamine have recently been reported to lower the rate of loss of articular cartilage in patients with hip OA and knee OA, respectively, based on measurements of the rate of joint space ..
  72. ncbi Articular cartilage defects in 1,000 knee arthroscopies
    Karin Hjelle
    Department of Orthopaedics, Deaconess Hospital, Haraldsplass, University of Bergen, Norway
    Arthroscopy 18:730-4. 2002
    ....
  73. pmc Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
    Xin Li
    Rush University Medical Center, Chicago, Illinois
    Arthritis Rheum 60:513-23. 2009
    ..To elucidate the pathophysiologic links between prostaglandin E(2) (PGE(2)) and osteoarthritis (OA) by characterizing the catabolic effects of PGE(2) and its unique receptors in human adult articular chondrocytes...
  74. ncbi Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro
    J Wang
    Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
    Osteoarthritis Cartilage 11:801-9. 2003
    In normal articular cartilage cells, the IGFRI/insulin-like growth factor 1 (IGF-1) autocrine pathway was shown to overrule the catabolic effects of the IL-1/IL-1RI pathway by up-regulation of the IL-1RII decoy receptor...
  75. ncbi Cell death and apoptosis in osteoarthritic cartilage
    H A Kim
    Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, Korea
    Curr Drug Targets 8:333-45. 2007
    ..Because the cardinal feature of OA is a progressive loss of articular cartilage, a great portion of the research endeavour into the pathogenesis of OA has been focused on the regulation ..
  76. ncbi Update on advanced surgical techniques in the treatment of traumatic focal articular cartilage lesions in the knee
    Nicholas A Sgaglione
    Division of Sports Medicine, North Shore University Hospital, Manhasset, New York, USA
    Arthroscopy 18:9-32. 2002
    ..has been developed over the past several years in expanding the treatment of symptomatic femoral condylar articular cartilage lesions in active patients...
  77. ncbi Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
    B C Sondergaard
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Osteoarthritis Cartilage 14:759-68. 2006
    ..We investigated direct effects of calcitonin on chondrocytes by assessing expression of the receptor and pharmacological effects on collagen type II degradation under ex vivo and in vivo conditions...
  78. ncbi Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation
    D M Salter
    Department of Pathology, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Biorheology 39:97-108. 2002
    Mechanical stimulation is critically important for the maintenance of normal articular cartilage integrity. Molecular events regulating responses of chondrocytes to mechanical forces are beginning to be defined...
  79. ncbi Biosynthetic response and mechanical properties of articular cartilage after injurious compression
    B Kurz
    Anatomisches Institut der CAU Kiel, Germany
    J Orthop Res 19:1140-6. 2001
    Traumatic joint injury is known to produce osteoarthritic degeneration of articular cartilage. To study the effects of injurious compression on the degradation and repair of cartilage in vitro, we developed a model that allows strain and ..
  80. ncbi Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
    Mehdi Shakibaei
    Institute of Anatomy, Musculoskeletal Research Group, Ludwig Maximilian University Munich, Pettenkoferstrasse 11, D 80336 Munich
    Ann N Y Acad Sci 1095:554-63. 2007
    ..These findings suggest that this dietary polyphenolic compound may have future applications in the nutraceutical-based therapy of human and animal OA...
  81. ncbi Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Bone Joint Surg Am 78:721-33. 1996
    Partial-thickness defects evolving in mature articular cartilage do not heal spontaneously...
  82. pmc Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes
    Shigeru Ohno
    Department of Biochemistry, Rush Medical College, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA
    J Biol Chem 281:17952-60. 2006
    ..the loss of extracellular matrix proteoglycan and collagen from cultured slices of normal adult human articular cartilage. This loss was coincident with an increased expression of matrix metalloproteinase (MMP)-13...
  83. ncbi Quantitative structural organization of normal adult human articular cartilage
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
    Osteoarthritis Cartilage 10:564-72. 2002
    Data pertaining to the quantitative structural features and organization of normal articular cartilage are of great importance in understanding its biomechanical properties and in attempting to establish this tissue's counterpart by ..
  84. ncbi Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration
    T Aigner
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 46:1986-96. 2002
  85. ncbi Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T
    T J Mosher
    Department of Radiology, Center for NMR Research, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey 17033, USA
    Radiology 214:259-66. 2000
    ..To determine if age and early symptomatic degeneration alter the spatial dependency of cartilage T2...
  86. ncbi Age-related changes in the morphology and deformational behavior of knee joint cartilage
    M Hudelmaier
    , Munich, Germany
    Arthritis Rheum 44:2556-61. 2001
    ..We show that under in vivo loading conditions, elderly subjects display a lower level of cartilage deformation than do healthy young subjects...
  87. pmc Treatment of focal articular cartilage defects in the knee: a systematic review
    Robert A Magnussen
    Vanderbilt Orthopaedic Institute, 4200 Medical Center East, 1215 21st Avenue South, Suite 4200, Nashville, TN, 37232 8774, USA
    Clin Orthop Relat Res 466:952-62. 2008
    ..outcomes compared with one another or with traditional abrasive techniques for treatment of isolated articular cartilage defects and whether lesion size influences this clinical outcome...
  88. ncbi Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis
    W Drexler
    Division of Orthopedic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, USA
    J Rheumatol 28:1311-8. 2001
    ..coherence tomography (OCT), a new method of high resolution imaging, has shown feasibility for assessing articular cartilage to identify early changes in osteoarthritis (OA) and monitor therapy...
  89. ncbi Joint diseases and matrix metalloproteinases: a role for MMP-13
    Hironari Takaishi
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Curr Pharm Biotechnol 9:47-54. 2008
    ..This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis...
  90. ncbi Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis
    David D Frisbie
    Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Am J Vet Res 68:290-6. 2007
    ..To assess the clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum (ACS) in the treatment of experimentally induced osteoarthritis in horses...
  91. ncbi Osteoarthritis cartilage histopathology: grading and staging
    K P H Pritzker
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Osteoarthritis Cartilage 14:13-29. 2006
    ..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
  92. ncbi Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo
    C De Bari
    University Hospitals Katholieke Universiteit Leuven, Belgium
    Arthritis Rheum 44:1608-19. 2001
    ..This cartilage-forming ability in vivo may be pivotal for successful cell-based joint surface defect repair protocols...
  93. pmc Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes
    V I Grishko
    Department of Cell Biology, University of South Alabama, Mobile, AL 36688 0002, USA
    Osteoarthritis Cartilage 17:107-13. 2009
    ..The aim of this study was to determine whether mtDNA damage was present in OA chondrocytes, and whether mtDNA repair capacity is compromised in OA chondrocytes following oxidative stress, leading to chondrocyte death...
  94. pmc Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
    L A Neuhold
    Molecular Genetics Division, Wyeth Ayerst Research, Princeton, New Jersey, USA
    J Clin Invest 107:35-44. 2001
    ..Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA...
  95. pmc Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes
    E Maneiro
    Laboratory of Investigation, Rheumatology Division, Juan Canalejo Hospital, C Xubias 84, 15006 A Coruna, Spain
    Ann Rheum Dis 64:388-95. 2005
    ..To investigate the effect of nitric oxide (NO) on mitochondrial activity and its relation with the apoptosis of human articular chondrocytes...
  96. ncbi Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis
    Lin Xu
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Arthritis Rheum 56:2663-73. 2007
    ..To investigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis of osteoarthritis (OA)...
  97. pmc Basic FGF mediates an immediate response of articular cartilage to mechanical injury
    Tonia Vincent
    The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Proc Natl Acad Sci U S A 99:8259-64. 2002
    ..ERK), one of the three types of mitogen-activated kinases, was rapidly activated after cutting porcine articular cartilage either when maintained as explants or in situ...
  98. ncbi Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells
    Jung Park
    Department of Oro Maxillo Facial Surgery, University of Erlangen Nuernberg, Germany
    J Gene Med 8:112-25. 2006
    Adult primary mesenchymal cells of different origin which can be obtained with minor donor site morbidity are considered for articular cartilage repair. This study aims at a comparison of their chondrogenic potential.
  99. pmc Site-specific effects of compression on macromolecular diffusion in articular cartilage
    Holly A Leddy
    Department of Surgery and Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biophys J 95:4890-5. 2008
    b>Articular cartilage is the connective tissue that lines joints and provides a smooth surface for joint motion...
  100. ncbi A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage
    S D Waldman
    Department of Mechanical and Materials Engineering, Queen s University, Kingston, Ontario, Canada
    Osteoarthritis Cartilage 14:323-30. 2006
    ..Thus, the purpose of this study was to investigate the effect of a single application of cyclic loading to chondrocytes on the formation and properties of in vitro-formed tissue...
  101. ncbi Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes
    Monika Hermansson
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, W6 8LH, UK
    J Biol Chem 279:43514-21. 2004
    We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry...

Research Grants101 found, 100 shown here

  1. ARTICULAR CARTILAGE REPAIR
    Robert Sah; Fiscal Year: 2000
    DESCRIPTION: (Adapted from investigator's abstract) Integrative repair of articular cartilage, defined as the healing of cartilage-cartilage or cartilage-tissue interfaces, is required in a number of orthopaedic conditions and rheumatic ..
  2. Novel Imaging Approach to Monitor Chondrogenic Differentiation of iPS Cells
    HEIKE ELIZABETH DALDRUP LINK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Articular cartilage defects are the major source of pain and functional impairment in patients with arthritis...
  3. SUBCUTANEOUS RHUIL10 THERAPY FOR RHEUMATOID ARTHRITIS
    EUGENE ST CLAIR; Fiscal Year: 2001
    ..It is characterized by synovial inflammation with frequent progression to articular cartilage and bone destruction...
  4. SUBCUTANEOUS RHUIL10 THERAPY FOR RHEUMATOID ARTHRITIS
    EUGENE ST CLAIR; Fiscal Year: 2000
    ..It is characterized by synovial inflammation with frequent progression to articular cartilage and bone destruction...
  5. SUBCUTANEOUS RHUIL10 THERAPY FOR RHEUMATOID ARTHRITIS
    EUGENE ST CLAIR; Fiscal Year: 1999
    ..It is characterized by synovial inflammation with frequent progression to articular cartilage and bone destruction...
  6. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..and transforming growth factor beta could be a useful agent in the treatment of osteoarthritis to limit articular cartilage degeneration and potentially facilitate its repair...
  7. STUDIES OF JOINT AGING AND OSTEOARTHRITIS
    Martin Lotz; Fiscal Year: 2009
    ..to utilize human knee joints from donors across the adult age spectrum to establish phenotypic changes in articular cartilage and chondrocytes that are characteristic of normal joint aging and may predispose to the development of ..
  8. Perlecan modulates VEGF Bio-Availability in Human Osteoarthritic Cartilage
    RONALD GOMES; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how human articular cartilage derived heparan sulfate proteoglycans bind to and modulate the activity of heparin binding growth factors important for ..
  9. Biologic scaffold prostheses to enhance meniscus repair
    JOE WEINBERG; Fiscal Year: 2009
    ..Meniscal damage or loss often results in progressive osteoarthritic degeneration of the articular cartilage and other joint tissues, leading to significant pain and disability...
  10. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2010
    ..Congenital defects, disease, and trauma to synovial joints, in particular to the articular cartilage that comprises a joint, are debilitating to billions of people...
  11. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2009
    ..Congenital defects, disease, and trauma to synovial joints, in particular to the articular cartilage that comprises a joint, are debilitating to billions of people...
  12. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2009
    ..Congenital defects, disease, and trauma to synovial joints, in particular to the articular cartilage that comprises a joint, are debilitating to billions of people...
  13. Selection of Therapeutic Agents for Articular Cartilage Repair
    STEPHEN TRIPPEL; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Articular cartilage is the gliding surface of diarthrodial joints. The loss of articular cartilage, through trauma or osteoarthritis, is a major cause of pain and disability...
  14. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  15. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2009
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  16. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    TARIQ HAQQI; Fiscal Year: 2009
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  17. Regulated Osteochondrogenesis of Human Mesenchymal Stem Cells Using Gene Delivery
    Antonios Mikos; Fiscal Year: 2009
    Regeneration of articular cartilage damaged either by disease or injury is a complex problem that remains a significant clinical challenge despite extensive orthopaedic research...
  18. HMGB2 in cartilage homeostasis, aging and osteoarthritis
    Martin Lotz; Fiscal Year: 2009
    ..Our preliminary studies show that the chromatin protein HMGB2 is exclusively expressed in the SZ of articular cartilage. We examined Hmgb2-/- mice and found more severe OA as compared to wild-type (WT) mice...
  19. HMGB2 in cartilage homeostasis, aging and osteoarthritis
    Martin K Lotz; Fiscal Year: 2010
    ..Our preliminary studies show that the chromatin protein HMGB2 is exclusively expressed in the SZ of articular cartilage. We examined Hmgb2-/- mice and found more severe OA as compared to wild-type (WT) mice...
  20. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..During the early stages of osteoarthritis, localized lesioning of the articular cartilage layer is a characteristic occurrence...
  21. Synovium-based articular cartilage tissue engineering
    Ernst Hunziker; Fiscal Year: 2006
    ..During the early stages of osteoarthritis, localized lesioning of the articular cartilage layer is a characteristic occurrence...
  22. Synovium-based articular cartilage tissue engineering
    Ernst Hunziker; Fiscal Year: 2009
    ..During the early stages of osteoarthritis, localized lesioning of the articular cartilage layer is a characteristic occurrence...
  23. Synovium-based articular cartilage tissue engineering
    Ernst Hunziker; Fiscal Year: 2007
    ..During the early stages of osteoarthritis, localized lesioning of the articular cartilage layer is a characteristic occurrence...
  24. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2006
    The long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  25. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2007
    The long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  26. Mechanisms of Joint Damage Following Tendon Injury
    Louis J Soslowsky; Fiscal Year: 2010
    ..This joint damage can be manifested as articular cartilage degeneration, injury to adjacent (intact) tendons, and abnormal joint kinematics and kinetics...
  27. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..The long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  28. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2009
    ..The long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  29. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The cellular repair response to damaged articular cartilage that has been characterized by traditional light microscopic technology suggests reactivation of the same chondrocyte lineage that ..
  30. Total Joint Resurfacing
    James Dennis; Fiscal Year: 2009
    Total Joint Resurfacing Previous attempts to repair articular cartilage have focused on the repair of focal defects...
  31. ARTICULAR CARTILAGE REPAIR
    Robert Sah; Fiscal Year: 1999
    DESCRIPTION: (Adapted from investigator's abstract) Integrative repair of articular cartilage, defined as the healing of cartilage-cartilage or cartilage-tissue interfaces, is required in a number of orthopaedic conditions and rheumatic ..
  32. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2003
    b>Articular cartilage is the bearing material of diarthrodial joints...
  33. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2001
    b>Articular cartilage is the bearing material of diarthrodial joints...
  34. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2000
    b>Articular cartilage is the bearing material of diarthrodial joints...
  35. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2002
    b>Articular cartilage is the bearing material of diarthrodial joints...
  36. Function and Regulation of CD-RAP
    Linda J Sandell; Fiscal Year: 2010
    ..combined to analyze groups of co-expressed genes and define common regulatory domains of genes expressed in articular cartilage. The current proposal will focus on extending these analyses to define transcriptional regulatory networks ..
  37. Function and Regulation of CD-RAP
    Linda Sandell; Fiscal Year: 2009
    ..combined to analyze groups of co-expressed genes and define common regulatory domains of genes expressed in articular cartilage. The current proposal will focus on extending these analyses to define transcriptional regulatory networks ..
  38. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..step, we evaluate the construct maturation, as well as their capacity to preserve the underlying articular cartilage. Methodology: Electrospun scaffolds will be fashioned in a novel tri-polymer electrospinning system we ..
  39. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance Chu; Fiscal Year: 2009
    ..New clinical strategies to improve evaluation, repair, and regeneration of damaged articular cartilage are needed to prevent or delay the onset of disabling pain and OA...
  40. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..New clinical strategies to improve evaluation, repair, and regeneration of damaged articular cartilage are needed to prevent or delay the onset of disabling pain and OA...
  41. AGE-RELATED DIFFERENCES IN CARTILAGE PROTEOGLYCANS
    Eugene Thonar; Fiscal Year: 1992
    ..They give articular cartilage its ability to undergo rapid reversible deformation...
  42. CARTILAGE MARKERS IN JOINT FLUID/SERUM AFTER MENISCUS INJURY/TREATMENT
    Bruce Beynnon; Fiscal Year: 1999
    Specific Aims: Study 1 1. To compare the concentration of articular cartilage markers (aggrecan, stromelysin, tissue inhibitor of metalloproteinases (TIMP), procollagen II C-peptide, cartilage and oligiometric matrix protein (COMP) in ..
  43. Cartilage Shaping for Biological Resurfacing/Replacement of the TMJ
    Gregory Williams; Fiscal Year: 2009
    ..Severe deterioration of the articular cartilage of the mandibular condyle can occur in advanced cases of TMJD and may necessitate surgical removal via ..
  44. Chondrogenic composite grafts for the repair of cartilage defects
    Jie Song; Fiscal Year: 2010
    ..provided by applicant): Traumatic injuries and age-related degenerative diseases associated with articular cartilage (AC) can result in significant patient morbidity and lead to the development of osteoarthritis...
  45. Chondrogenic composite grafts for the repair of cartilage defects
    Jie Song; Fiscal Year: 2009
    ..provided by applicant): Traumatic injuries and age-related degenerative diseases associated with articular cartilage (AC) can result in significant patient morbidity and lead to the development of osteoarthritis...
  46. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2009
    b>Articular cartilage exhibits a poor intrinsic healing capacity when injured in trauma or by degenerative diseases such as osteoarthritis (OA)...
  47. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2002
    Degeneration of articular cartilage occurs with aging and accelerated in osteoarthritis (OA). However, the mechanisms responsible for these changes are currently unknown...
  48. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2005
    Degeneration of articular cartilage occurs with aging and accelerated in osteoarthritis (OA). However, the mechanisms responsible for these changes are currently unknown...
  49. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2004
    Degeneration of articular cartilage occurs with aging and accelerated in osteoarthritis (OA). However, the mechanisms responsible for these changes are currently unknown...
  50. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    Clark T Hung; Fiscal Year: 2010
    b>Articular cartilage exhibits a poor intrinsic healing capacity when injured in trauma or by degenerative diseases such as osteoarthritis (OA)...
  51. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2003
    Degeneration of articular cartilage occurs with aging and accelerated in osteoarthritis (OA). However, the mechanisms responsible for these changes are currently unknown...
  52. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    Clark T Hung; Fiscal Year: 2010
    b>Articular cartilage exhibits a poor intrinsic healing capacity when injured in trauma or by degenerative diseases such as osteoarthritis (OA)...
  53. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2001
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  54. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2000
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  55. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2000
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  56. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2001
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  57. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2002
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  58. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2003
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  59. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2002
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  60. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2003
    b>Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics...
  61. JUVENILE RHEUMATOID ARTHRITIS: MRI ANALYSIS
    Bernard Dardzinski; Fiscal Year: 2001
    ..The end result of ongoing synovial inflammation is degradation of articular cartilage. Whether the control of synovitis halts further cartilage degradation is not known...
  62. Biologically Enhanced Healing of Autograft ACL Reconstruction.
    Braden Fleming; Fiscal Year: 2009
    ..Thus, techniques to enhance graft healing to reduce early laxity, protect the joint, and preserve articular cartilage would provide better long-term outcome for the ACL injured patient...
  63. Fate mapping and signaling pathways of superficial cells in articular cartilage
    ANDREW BRUCE LASSAR; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Osteoarthritis is a degenerative disease of the articular cartilage, a tissue that covers the surface of all articulating joints in the human body. It is estimated that 20...
  64. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2001
    ..the menisci play in the general biomedical functioning of the knee joint and the specific protection of articular cartilage. The data in the literature supporting a casual relationship between tears and meniscus and damage to the ..
  65. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2000
    ..the menisci play in the general biomedical functioning of the knee joint and the specific protection of articular cartilage. The data in the literature supporting a casual relationship between tears and meniscus and damage to the ..
  66. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2002
    ..the menisci play in the general biomedical functioning of the knee joint and the specific protection of articular cartilage. The data in the literature supporting a casual relationship between tears and meniscus and damage to the ..
  67. A Standard Animal Model for Articular Cartilage Repair
    Anthony Ratcliffe; Fiscal Year: 2010
    ..There are a growing number of new technologies and methodologies attempting to address articular cartilage repair, however there is no uniform method of assessing their safety and effectiveness or efficacy...
  68. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ..Our long-term objective is to develop a clinically applicable biologic arthroplasty approach for treating articular cartilage loss due to injury or osteoarthritis in humans...
  69. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2006
    ..Our long-term objective is to develop a clinically applicable biologic arthroplasty approach for treating articular cartilage loss due to injury or osteoarthritis in humans...
  70. MOLECULAR BIOLOGY OF HERITABLE OSTEOARTHRITIS
    Sergio Jimenez; Fiscal Year: 1990
    ..is to test the hypothesis that mutations in the genes that encode for the extracellular components of articular cartilage. In particular for the collages of the tissue cause certain forms of heritable osteoarthritis in man...
  71. Mechanisms of Articular Cartilage Lubrication
    Robert Sah; Fiscal Year: 2009
    b>Articular cartilage is one of a number of tissues in the body that bears load and slides relative to an apposing tissue surface with remarkable tribological propertieslow friction, low wear, and multiple modes of lubrication acting to ..
  72. Mechanisms of Articular Cartilage Lubrication
    Robert Sah; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Articular cartilage is one of a number of tissues in the body that bears load and slides relative to an apposing tissue surface with remarkable tribological properties -- low friction, ..
  73. Mechanisms of Articular Cartilage Lubrication
    Robert Sah; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Articular cartilage is one of a number of tissues in the body that bears load and slides relative to an apposing tissue surface with remarkable tribological properties -- low friction, ..
  74. Gene Transfer of Growth Factors and Receptors as Therap*
    Ernest Terwilliger; Fiscal Year: 2002
    ..and overexpression of three distinct genes, separately as well as in combination, upon the healing of articular cartilage lesions in vivo...
  75. Gene Transfer of Growth Factors and Receptors
    Ernest Terwilliger; Fiscal Year: 2001
    ..and overexpression of three distinct genes, separately as well as in combination, upon the healing of articular cartilage lesions in vivo...
  76. Collagen Assembly in Tissue-Engineered Cartilage
    Russell J Fernandes; Fiscal Year: 2010
    ..challenge has been to increase the collagen content of bioengineered cartilage to levels observed in native articular cartilage. Since the collagen heteropolymer is a crucial template of the mature fibrillar architecture and for the ..
  77. Ihh and PTHrP Regulate Articular Chondrocyte Maintenance
    ARTHUR EASTWOOD BROADUS; Fiscal Year: 2010
    ..We have found that the Ihh-PTHrP axis is operative also in embryonic and in established articular cartilage. In the embryo, the Ihh-PTHrP axis prevents mineralization of the nascent joint...
  78. Leukocyte adhesion molecules modulate inflammation of cartilage in joint trauma
    Dejan Milentijevic; Fiscal Year: 2009
    ..Influx of leukocytes into the joint can cause a secondary insult to already traumatized articular cartilage which may predispose the joint to develop post-traumatic arthritis...
  79. Leukocyte adhesion molecules modulate inflammation of cartilage in joint trauma
    Dejan Milentijevic; Fiscal Year: 2010
    ..Influx of leukocytes into the joint can cause a secondary insult to already traumatized articular cartilage which may predispose the joint to develop post-traumatic arthritis...
  80. Design and Evaluation of Ultrasound Stimulation Aided Bioreactor Configurations
    Anu Subramanian; Fiscal Year: 2009
    b>Articular cartilage, the avascular tissue that covers the ends of synovial joints and provides articulating joints with a durable, weight-distributing surface, damaged by illness or trauma has little capacity for self-repair...
  81. In Situ Polymerizing Biodendrimer Scaffolds for Articular Cartilage Repair
    ROBERT NASLUND; Fiscal Year: 2006
    ..or known to be biocompatible, that can be custom-designed to provide a unique scaffold appropriate for articular cartilage repair...
  82. Design and Evaluation of Ultrasound Stimulation Aided Bioreactor Configurations
    Anu Subramanian; Fiscal Year: 2010
    b>Articular cartilage, the avascular tissue that covers the ends of synovial joints and provides articulating joints with a durable, weight-distributing surface, damaged by illness or trauma has little capacity for self-repair...
  83. Hybrid Composite Scaffolds for Cartilage Tissue Engineering
    GEOFFREY ERICKSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Damage and subsequent degeneration of articular cartilage in the form of osteoarthritis represents a major health issue globally, and current estimates report that by the year 2020, over 59 million ..
  84. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 1999
    ..The causes of CPPD crystal formation in aging articular cartilage are unknown, although many similarities exist between processes of normal cartilage mineralization in ..
  85. AGE RELATED DIFFERENCES IN CARTILAGE PROTEOGLYCANS
    Eugene Thonar; Fiscal Year: 2000
    Aggrecan, the most abundant proteoglycan in articular cartilage, gives the tissue many of its functional properties, including its ability to undergo rapid reversible deformation...
  86. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2002
    ..The causes of CPPD crystal formation in aging articular cartilage are unknown, although many similarities exist between processes of normal cartilage mineralization in ..
  87. MOLECULAR BIOLOGY OF HERITABLE OSTEOARTHRITIS
    Sergio Jimenez; Fiscal Year: 1992
    ..to test further the hypothesis that mutations in the genes that encode for the extracellular components of articular cartilage, in particular the collagens of the tissue, cause heritable forms of osteoarthrits and related disorders of ..
  88. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2007
    ..is to develop a targeting strategy for pre-chondrocytes so that these cells can be used to repair an articular cartilage defect in vivo...
  89. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2006
    ..is to develop a targeting strategy for pre-chondrocytes so that these cells can be used to repair an articular cartilage defect in vivo...
  90. CARTILAGE MECHANICS IN SMALL ANIMAL MODELS OF OA
    Lori Setton; Fiscal Year: 2003
    ..is believed to play important roles in controlling the microstructural organization and composition of articular cartilage during growth and maturation...
  91. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2004
    ..is to develop a targeting strategy for pre-chondrocytes so that these cells can be used to repair an articular cartilage defect in vivo...
  92. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2005
    ..is to develop a targeting strategy for pre-chondrocytes so that these cells can be used to repair an articular cartilage defect in vivo...
  93. REGULATION OF COLLAGENASE 3 GENE EXPRESSION BY CYTOKINES
    Mahboob Rahman; Fiscal Year: 2001
    ..collagenase-3 gene expression in order to better understand the mechanisms involved in the degradation of articular cartilage in rheumatic diseases such as rheumatoid arthritis (RA) and osteoarthritis ( OA)...
  94. REGULATION OF COLLAGENASE 3 GENE EXPRESSION BY CYTOKINES
    Mahboob Rahman; Fiscal Year: 2000
    ..collagenase-3 gene expression in order to better understand the mechanisms involved in the degradation of articular cartilage in rheumatic diseases such as rheumatoid arthritis (RA) and osteoarthritis ( OA)...
  95. REGULATION OF COLLAGENASE 3 GENE EXPRESSION BY CYTOKINES
    Mahboob Rahman; Fiscal Year: 1999
    ..collagenase-3 gene expression in order to better understand the mechanisms involved in the degradation of articular cartilage in rheumatic diseases such as rheumatoid arthritis (RA) and osteoarthritis ( OA)...
  96. REGULATION OF COLLAGENASE 3 GENE EXPRESSION BY CYTOKINES
    Mahboob Rahman; Fiscal Year: 2002
    ..collagenase-3 gene expression in order to better understand the mechanisms involved in the degradation of articular cartilage in rheumatic diseases such as rheumatoid arthritis (RA) and osteoarthritis ( OA)...
  97. Tissue Engineering of Temporomandibular Joint Cartilage
    STEVEN NICOLL; Fiscal Year: 2004
    ..Given recent evidence for the causative roles of OA in disc displacement, restoration of the TMJ articular cartilage may be a more effective approach to restoring joint function...
  98. In Vivo Performance of Osteochondral Allografts
    William Bugbee; Fiscal Year: 2009
    In the skeletally mature individual, hyaline articular cartilage does not heal effectively when injured and the natural progression of acquired articular cartilage defects is predictably poor, commonly culminating in joint arthrosis...