articular cartilage

Summary

Top Publications

  1. doi Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    Mary B Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann N Y Acad Sci 1192:230-7. 2010
  2. ncbi An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
  3. ncbi Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis
    A Mobasheri
    Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Brownlow Hill and Crown Street, Liverpool, L69 7ZJ UK
    Med Hypotheses 58:193-7. 2002
  4. ncbi The role of reactive oxygen species in homeostasis and degradation of cartilage
    Y E Henrotin
    Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
    Osteoarthritis Cartilage 11:747-55. 2003
  5. ncbi Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage
    Saifeddin Alsalameh
    Division of Arthritis Research MEM 161, The Scripps Research Institute, La Jolla, CA 92037, USA
    Arthritis Rheum 50:1522-32. 2004
  6. ncbi Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho)
    L Xu
    Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 48:2509-18. 2003
  7. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
  8. pmc The subchondral bone in articular cartilage repair: current problems in the surgical management
    Andreas H Gomoll
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
    Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
  9. doi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
  10. doi Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
    Francesco Dell'accio
    Barts and the London School of Medicine and Dentistry, London, UK
    Arthritis Rheum 58:1410-21. 2008

Detail Information

Publications445 found, 100 shown here

  1. doi Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    Mary B Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann N Y Acad Sci 1192:230-7. 2010
    ..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
  2. ncbi An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
    ..A small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to OA...
  3. ncbi Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis
    A Mobasheri
    Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Brownlow Hill and Crown Street, Liverpool, L69 7ZJ UK
    Med Hypotheses 58:193-7. 2002
    ..This understanding is essential for developing appropriately targeted anti-protease therapies for the inhibition of chondrocyte apoptosis in the rational treatment of osteoarthritis...
  4. ncbi The role of reactive oxygen species in homeostasis and degradation of cartilage
    Y E Henrotin
    Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
    Osteoarthritis Cartilage 11:747-55. 2003
    ..ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable...
  5. ncbi Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage
    Saifeddin Alsalameh
    Division of Arthritis Research MEM 161, The Scripps Research Institute, La Jolla, CA 92037, USA
    Arthritis Rheum 50:1522-32. 2004
    To determine the presence of mesenchymal progenitor cells (MPCs) in human articular cartilage.
  6. ncbi Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho)
    L Xu
    Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 48:2509-18. 2003
    ..of type XI collagen (Col11a1) in mice (chondrodysplasia, cho) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mutation on articular cartilage in knee and temporomandibular (TM) joints.
  7. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
    ..Unlike most cartilage, articular cartilage is arrested before terminal hypertrophic differentiation...
  8. pmc The subchondral bone in articular cartilage repair: current problems in the surgical management
    Andreas H Gomoll
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
    Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
    As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the ..
  9. doi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
    ..The aim of this study was to determine the prevalence and composition of calcium crystals in human OA and analyze their relationship to disease severity and markers of chondrocyte hypertrophy...
  10. doi Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
    Francesco Dell'accio
    Barts and the London School of Medicine and Dentistry, London, UK
    Arthritis Rheum 58:1410-21. 2008
    To characterize the molecular response of adult human articular cartilage to acute mechanical injury.
  11. ncbi Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, Switzerland
    Osteoarthritis Cartilage 10:432-63. 2002
    To review the basic scientific status of repair in articular cartilage tissue and to assess the efficiency of current clinical therapies instigated for the treatment of structural lesions generated therein as a result of trauma or during ..
  12. ncbi Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Tadashi Hayami
    Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
    Bone 38:234-43. 2006
    ..Using a modified Mankin scoring system, we demonstrate that articular cartilage damage occurs within 2 weeks post-surgery in both surgical models...
  13. ncbi Boundary lubrication of articular cartilage: role of synovial fluid constituents
    Tannin A Schmidt
    University of California, San Diego, La Jolla, CA 92093, USA
    Arthritis Rheum 56:882-91. 2007
    ..the synovial fluid (SF) constituents hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPL) contribute to boundary lubrication, either independently or additively, at an articular cartilage-cartilage interface.
  14. ncbi Articular cartilage: injury pathways and treatment options
    Timothy M Simon
    Orthopaedic Research Institute and the Southern California Center for Sports Medicine, Long Beach, CA 90806, USA
    Sports Med Arthrosc 14:146-54. 2006
    b>Articular cartilage injury and degeneration is a frequent occurrence in synovial joints...
  15. ncbi Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage
    M J Nissi
    Department of Applied Physics, University of Kuopio, and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    J Orthop Res 22:557-64. 2004
    ..imaging (MRI) techniques have earlier been developed to characterize the structure and composition of articular cartilage. Particularly, Gd-DTPA(2-)-enhanced T1 imaging is sensitive to cartilage proteoglycan content, while T2 ..
  16. doi ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
    Indira Prasadam
    Queensland University of Technology, Brisbane, Queensland, Australia
    Arthritis Rheum 62:1349-60. 2010
    Previous studies have shown the influence of subchondral bone osteoblasts (SBOs) on phenotypical changes of articular cartilage chondrocytes (ACCs) during the development of osteoarthritis (OA)...
  17. pmc Major biological obstacles for persistent cell-based regeneration of articular cartilage
    Andre F Steinert
    Orthopaedic Center for Musculoskeletal Research, König Ludwig Haus, Julius Maximilians University, Wurzburg, Germany
    Arthritis Res Ther 9:213. 2007
    Hyaline articular cartilage, the load-bearing tissue of the joint, has very limited repair and regeneration capacities...
  18. ncbi Quantitative structural organization of normal adult human articular cartilage
    E B Hunziker
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, P O Box 30, Switzerland
    Osteoarthritis Cartilage 10:564-72. 2002
    Data pertaining to the quantitative structural features and organization of normal articular cartilage are of great importance in understanding its biomechanical properties and in attempting to establish this tissue's counterpart by ..
  19. doi Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction
    Walter Dunn
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA 95817, USA
    Arthritis Rheum 60:2333-9. 2009
    b>Articular cartilage is an avascular tissue with precise polarity and organization comprising 3 distinct functional zones: the surface, middle, and deep zones...
  20. ncbi Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging
    S K de Visser
    School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Osteoarthritis Cartilage 16:83-9. 2008
    To demonstrate the use of diffusion tensor magnetic resonance micro-imaging to observe adaptations of collagen fibres to mechanical compression in articular cartilage.
  21. ncbi Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes
    L C Tetlow
    University Department of Medicine, Manchester Royal Infirmary, The University of Manchester, UK
    Arthritis Rheum 44:585-94. 2001
    ..tumor necrosis factor alpha (TNFalpha) in osteoarthritic (OA) cartilage compared with normal, age-matched articular cartilage. METHODS: Articular cartilage samples were obtained from the tibial plateau of OA knees removed at ..
  22. ncbi Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage
    M Sabatini
    Division of Rheumatology, Institut de Recherches Servier, Suresnes, France
    Biochem Biophys Res Commun 267:438-44. 2000
    ..degradation, matrix-metalloproteinase (MMP) expression and activity, and chondrocyte apoptosis in rabbit articular cartilage. Cell-permeant ceramide C(2) stimulated proteoglycan degradation in cartilage explants starting from 3 x 10(..
  23. pmc Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology
    Emma J Blain
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Cardiff, UK
    Int J Exp Pathol 90:1-15. 2009
    ..review will primarily focus on the organization and function of the three major cytoskeletal networks in articular cartilage chondrocytes...
  24. ncbi Rapid phenotypic changes in passaged articular chondrocyte subpopulations
    Eric M Darling
    Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
    J Orthop Res 23:425-32. 2005
    Articular chondrocytes are often expanded in vitro and then used to assist in healing articular cartilage defects...
  25. doi Strategies for articular cartilage lesion repair and functional restoration
    Tamer A E Ahmed
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Tissue Eng Part B Rev 16:305-29. 2010
    Injury of articular cartilage due to trauma or pathological conditions is the major cause of disability worldwide, especially in North America...
  26. doi Characterization of metalloprotease cleavage products of human articular cartilage
    Eugene Y Zhen
    Eli Lilly and Company, Greenfield, IN 46140, USA
    Arthritis Rheum 58:2420-31. 2008
    To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage.
  27. doi Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
    Yasunobu Sawaji
    Imperial College London, London, UK
    Arthritis Rheum 58:3498-509. 2008
    Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage.
  28. ncbi The surface of articular cartilage contains a progenitor cell population
    Gary P Dowthwaite
    Cardiff School of Biosciences and Cardiff Institute of Tissue Engineering and Repair, Cardiff University, PO Box 911, Museum Avenue, Cardiff CF10 3US, UK
    J Cell Sci 117:889-97. 2004
    It is becoming increasingly apparent that articular cartilage growth is achieved by apposition from the articular surface...
  29. ncbi Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Cell Transplant 13:595-600. 2004
    ..the effectiveness of autologous bone marrow stromal cell transplantation for the repair of full-thickness articular cartilage defects in the patellae of a 26-year-old female and a 44-year-old male...
  30. ncbi Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage
    Paul J Fanning
    Massachusetts General Hospital, Orthopaedic Research Laboratories, and Harvard Medical School, Boston, Massachusetts, USA
    J Biol Chem 278:50940-8. 2003
    ..Finally, the data indicate that compression coactivates distinct signaling pathways that may help define the nature of mechanotransduction in cartilage...
  31. ncbi Tissue engineering of stratified articular cartilage from chondrocyte subpopulations
    T J Klein
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Osteoarthritis Cartilage 11:595-602. 2003
    ..Constructs were cultured for 1 or 2 weeks and were assessed for growth, compressive properties, and deposition, and localization of matrix molecules and superficial zone protein (SZP)...
  32. ncbi Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells
    R Kuroda
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
    Osteoarthritis Cartilage 15:226-31. 2007
    ..This study assessed the effectiveness of autologous bone-marrow stromal cells, which were embedded within a collagen scaffold, to repair a full-thickness articular cartilage defect in the medial femoral condyle of an athlete.
  33. ncbi Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees
    Shigeyuki Wakitani
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Tissue Eng Regen Med 1:74-9. 2007
    ..the effectiveness of autologous culture-expanded bone marrow mesenchymal cell transplantation for repairing articular cartilage defects, we transplanted autologous culture-expanded bone marrow mesenchymal cells into nine full-thickness ..
  34. ncbi Basic science of articular cartilage and osteoarthritis
    Andrew D Pearle
    Shoulder and Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    Clin Sports Med 24:1-12. 2005
    b>Articular cartilage is a specialized tissue uniquely suited for load distribution with a low-friction articulating surface...
  35. doi Articular cartilage: structure, injuries and review of management
    Abhijit M Bhosale
    Institute of Orthopaedics and Arthritis Research Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, UK
    Br Med Bull 87:77-95. 2008
    Chondral and osteochondral injuries are commonly seen in today's clinical practice. Articular cartilage provides an ultimate low-friction gliding surface, which none of the artificial constructs have been able to replace successfully...
  36. ncbi Current strategies for articular cartilage repair
    S N Redman
    CITER, Cardiff School of Biosciences, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Eur Cell Mater 9:23-32; discussion 23-32. 2005
    Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal spontaneously...
  37. ncbi Osteoarthritis and cartilage: the role of cytokines
    M B Goldring
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Room 246, 4 Blackfan Circle, Boston, MA 02115, USA
    Curr Rheumatol Rep 2:459-65. 2000
    ..biochemical, and genetic factors that contribute to the imbalance in the synthesis and destruction of articular cartilage. It is now well documented that interleukin-1 and tumor necrosis factor-alpha are the predominant ..
  38. ncbi Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes
    Andrea Barbero
    University Hospital, Basel, Switzerland
    Arthritis Rheum 48:1315-25. 2003
    ....
  39. ncbi Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis
    D A Walsh
    Academic Rheumatology, University of Nottingham Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Osteoarthritis Cartilage 15:743-51. 2007
    ..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA...
  40. ncbi Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB
    T Shalom-Barak
    Division of Arthritis Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:27467-73. 1998
    ..These results suggest that IL-17 activation of chondrocytes is associated with and depends at least in part on the activation of MAP kinases and NF-kappaB...
  41. doi Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics
    S Saarakkala
    Department of Physics, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 18:73-81. 2010
    Osteoarthritis (OA) is characterized by the changes in structure and composition of articular cartilage. However, it is not fully known, what is the depth-wise change in two major components of the cartilage solid matrix, i.e...
  42. ncbi The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage
    Farshid Guilak
    Orthopaedic Research Laboratories, Department of Surgery, Division of Orthopaedic Surgery, 375 MSRB, Box 3093, Duke University Medical Center, Durham, NC 27710, USA
    Ann N Y Acad Sci 1068:498-512. 2006
    The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular cartilage, which together with the enclosed cell(s) has been termed the "chondron...
  43. ncbi Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study
    Shengda Zhou
    Oxford University, Oxford, UK
    Arthritis Rheum 50:3915-24. 2004
    ..information on the gradients of oxygen concentration from the synovial surface to the subchondral bone in articular cartilage. Cartilage is usually regarded as hypoxic, even though cellular metabolism is inhibited at low oxygen ..
  44. ncbi A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee
    D D Frisbie
    Orthopaedic Research Center, Department of Clinical Sciences, Colorado State University, Ft Collins, Colorado 80525, USA
    Vet Comp Orthop Traumatol 19:142-6. 2006
    ..on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee...
  45. ncbi The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
    Tadashi Hayami
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Arthritis Rheum 50:1193-206. 2004
    ....
  46. ncbi Mechanisms for asporin function and regulation in articular cartilage
    Masahiro Nakajima
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:32185-92. 2007
    ..OA is characterized by the loss of articular cartilage; however, the details of its etiology and pathogenesis remain unclear...
  47. ncbi Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis
    C G Peterfy
    Synarc, Inc, San Francisco, CA 94105, USA
    Osteoarthritis Cartilage 12:177-90. 2004
    ..To determine the inter-observer agreement of this scoring method. To examine associations among the features included in the scoring method...
  48. ncbi Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression
    H Tonomura
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Osteoarthritis Cartilage 14:545-53. 2006
    ..To investigate the effect of l-glutamine (Gln) on stress responses of chondrocytes exposed to heat stress or nitric oxide (NO)...
  49. ncbi The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
    ..Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression...
  50. doi Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 18:735-41. 2010
    ..Although BMPs are considered protective for articular cartilage these factors can also be involved in chondrocyte hypertrophy and matrix degradation...
  51. ncbi Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants
    C A M Huser
    University of Cambridge, Cambridge, UK
    Arthritis Rheum 56:2322-34. 2007
    ..This study aimed to elucidate the mechanisms involved upstream of caspase 9 activation and, in particular, calcium signaling and mitochondrial depolarization...
  52. doi DT-MRI based computation of collagen fiber deformation in human articular cartilage: a feasibility study
    David M Pierce
    Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, Kronesgasse 5 I, Graz, Austria
    Ann Biomed Eng 38:2447-63. 2010
    ..To model the complex morphology and response of articular cartilage, a hyperviscoelastic (dispersed) fiber-reinforced constitutive model is employed to complete two specimen-..
  53. pmc Quantitative assessment of articular cartilage morphology via EPIC-microCT
    L Xie
    George W Woodruff School of Mechanical Engineering, 315 Ferst Drive, Georgia Institute of Technology, Atlanta, GA 30332 0405, United States
    Osteoarthritis Cartilage 17:313-20. 2009
    ..The objective of the present study was to validate the ability of Equilibrium Partitioning of an Ionic Contrast agent via microcomputed tomography (EPIC-microCT) to nondestructively assess cartilage morphology in the rat model...
  54. ncbi Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture, and osteochondral autograft transplantation
    Alberto Gobbi
    Orthopaedic Arthroscopic Surgery International, Milan, Italy
    Arthroscopy 22:1085-92. 2006
    ..The purpose of this study was to compare outcomes of chondroplasty versus microfracture versus osteochondral autologous transplantation (OAT) in patients with osteochondral lesions of the talus (OLT)...
  55. doi Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis
    A Kadri
    INSERM U606, Universite Paris 7, Paris, France
    Arthritis Rheum 58:2379-86. 2008
    ..To characterize bone microarchitectural changes and to test the hypothesis that disrupting local cytokine equilibrium could modify cartilage degradation in a murine model of experimental osteoarthritis (OA)...
  56. ncbi Spatial assessment of articular cartilage proteoglycans with Gd-DTPA-enhanced T1 imaging
    Miika T Nieminen
    Department of Anatomy, University of Kuopio, Finland
    Magn Reson Med 48:640-8. 2002
    In Gd-DTPA-enhanced T(1) imaging of articular cartilage, the MRI contrast agent with two negative charges is understood to accumulate in tissue inversely to the negative charge of cartilage glycosaminoglycans (GAGs) of proteoglycans (PGs)..
  57. ncbi ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
    Lisa A Collins-Racie
    Department of Discovery Medicine, Wyeth Research, Cambridge, MA 02140, USA
    Matrix Biol 23:219-30. 2004
    ..proteoglycan aggrecan, and ADAMTS-4 and ADAMTS-5 have been postulated to play a role in the depletion of articular cartilage in osteoarthritic disease...
  58. pmc Assessing degeneration of human articular cartilage with ultra-short echo time (UTE) T2* mapping
    A Williams
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Osteoarthritis Cartilage 18:539-46. 2010
    To examine the sensitivity of ultra-short echo time (UTE) T(2)* mapping to collagen matrix degeneration in human articular cartilage.
  59. ncbi Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice
    Solmaz Sahebjam
    Shriners Hospital for Children and McGill University, Montreal, Quebec, Canada
    Arthritis Rheum 56:905-9. 2007
    To investigate the in vivo effect of an imbalance between metalloproteinases and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in mouse articular cartilage.
  60. ncbi 3D-T1rho-relaxation mapping of articular cartilage: in vivo assessment of early degenerative changes in symptomatic osteoarthritic subjects
    Ravinder Reddy Regatte
    Metabolic Magnetic Resonance Resource and Computing Center MMRRCC, Department of Radiology, B1, Stellar Chance Laboratories, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6100, USA
    Acad Radiol 11:741-9. 2004
    ..To determine the in vivo feasibility of quantifying early degenerative changes in patellofemoral joint of symptomatic human knee using spin-lattice relaxation time in the rotating frame (T(1rho)) magnetic resonance imaging (MRI)...
  61. ncbi Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China
    J Cao
    Institute of Endemic Diseases, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, PR China
    Osteoarthritis Cartilage 16:680-8. 2008
    ..5 million of 30 million people living in the KBD regions of China...
  62. pmc Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
    J Dudhia
    Kennedy Institute of Rheumatology, Hammersmith, London, U K
    Biochem J 313:933-40. 1996
    The content of the C-terminal region of aggrecan was investigated in samples of articular cartilage from individuals ranging in age from newborn to 65 years...
  63. doi Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure
    Petro Julkunen
    Department of Clinical Neurophysiology, Kuopio University Hospital, POB 1777, FI 70211, Kuopio, Finland
    J Biomech 41:1978-86. 2008
    Mechanical properties of articular cartilage are controlled by tissue composition and structure. Cartilage function is sensitively altered during tissue degeneration, in osteoarthritis (OA)...
  64. doi Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    S J Gilbert
    Cardiff University, Cardiff, Wales, UK
    Arthritis Rheum 58:209-20. 2008
    ..proinflammatory cytokine signaling, induces cartilage degradation and reduces type II collagen synthesis in articular cartilage. The accumulation of ceramide is associated with arthritis in Farber's disease...
  65. ncbi Characterization of mature vs aged rabbit articular cartilage: analysis of cell density, apoptosis-related gene expression and mechanisms controlling chondrocyte apoptosis
    R Todd Allen
    Department of Orthopaedic Surgery, University of California San Diego, La Jolla, CA 92093 0630, USA
    Osteoarthritis Cartilage 12:917-23. 2004
    ..To address the question of whether age predisposes articular cartilage to apoptosis, the objective of the present study was to characterize and compare in aged and mature non-OA ..
  66. ncbi T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study
    M T Nieminen
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    Magn Reson Med 46:487-93. 2001
    It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise T2 anisotropy of MRI through the magic angle effect...
  67. ncbi Sulfation of chondroitin sulfate in human articular cartilage. The effect of age, topographical position, and zone of cartilage on tissue composition
    M T Bayliss
    Royal Veterinary College, Royal College Street, London NW1 OTU, United Kingdom
    J Biol Chem 274:15892-900. 1999
    The chondroitin ABC lyase digestion products of normal human femoral condyle articular cartilage and of purified aggrecan were analyzed for their mono- and nonsulfated disaccharide composition...
  68. ncbi The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope study and review
    L C Hughes
    The University of Wales Bioimaging Laboratory, Institute of Biological Sciences, Aberystwyth, Wales, UK
    Eur Cell Mater 9:68-84. 2005
    Adult mouse articular cartilage (AC) has not been thoroughly described using high resolution imaging techniques, despite the fact that the availability of knockout mice with specific extracellular matrix (ECM) mutations have renewed ..
  69. ncbi Osteoarthritis
    Mary B Goldring
    Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
    J Cell Physiol 213:626-34. 2007
    Osteoarthritis (OA) is characterized by degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and changes in peri-articular and subchondral bone...
  70. doi Management of articular cartilage defects of the knee
    Asheesh Bedi
    Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    J Bone Joint Surg Am 92:994-1009. 2010
    b>Articular cartilage has a poor intrinsic capacity for healing. The goal of surgical techniques to repair articular cartilage injuries is to achieve the regeneration of organized hyaline cartilage...
  71. ncbi A three-dimensional osteochondral composite scaffold for articular cartilage repair
    Jill K Sherwood
    Therics, Inc, 115 Campus Drive, Princeton, NJ 08540, USA
    Biomaterials 23:4739-51. 2002
    There is a recognized and urgent need for improved treatment of articular cartilage defects...
  72. ncbi Repair of large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into beta-tricalcium phosphate in a sheep model
    Ximin Guo
    Institute of Basic Medical Sciences of Beijing, Beijing, People s Republic of China
    Tissue Eng 10:1818-29. 2004
    Tissue engineering has long been investigated to repair articular cartilage defects. Successful reports have usually involved the seeding of autologous chondrocytes into polymers...
  73. ncbi Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
    C Zorzi
    Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
    Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
    Severe joint inflammation following trauma, arthroscopic surgery or infection can damage articular cartilage, thus every effort should be made to protect cartilage from the catabolic effects of pro-inflammatory cytokines and stimulate ..
  74. ncbi Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions
    Elena V Tchetina
    Joint Diseases Laboratory, Shriners Hospitals for Children, Montreal, Quebec, Canada
    J Rheumatol 32:876-86. 2005
    b>Articular cartilage degeneration in osteoarthritis (OA) involves excessive degradation of extracellular matrix (ECM) and chondrocyte differentiation (hypertrophy)...
  75. ncbi Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging
    Miika T Nieminen
    Department of Anatomy, University of Kuopio, Kuopio, Finland
    J Biomech 37:321-8. 2004
    ..MRI) is the most potential non-invasive means for revealing the structure, composition and pathology of articular cartilage. Here we hypothesize that cartilage mechanical properties as determined by the macromolecular framework and ..
  76. pmc Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
    L A Neuhold
    Molecular Genetics Division, Wyeth Ayerst Research, Princeton, New Jersey, USA
    J Clin Invest 107:35-44. 2001
    ..Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA...
  77. doi Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis
    L A Collins-Racie
    Department of Biological Technologies, Cambridge, MA 02140, USA
    Osteoarthritis Cartilage 17:832-42. 2009
    Compare the expression and regulation of nuclear receptors (NRs) in osteoarthritic and normal human articular cartilage.
  78. ncbi Osteophytes: relevance and biology
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Center Nijmegen, The Netherlands
    Osteoarthritis Cartilage 15:237-44. 2007
    ..Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes...
  79. ncbi Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique
    T B F Woodfield
    Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Biomaterials 25:4149-61. 2004
    ..PEGT/PBT) block co-polymer scaffolds with a 100% interconnecting pore network for engineering of articular cartilage. The technique allowed us to "design-in" desired scaffold characteristics layer by layer by accurately ..
  80. doi New techniques in articular cartilage imaging
    Hollis G Potter
    Magnetic Resonance Imaging, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Clin Sports Med 28:77-94. 2009
    ..MRI provides an essential objective assessment of cartilage regenerative procedures...
  81. doi Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants
    Christoph Erggelet
    Department of Traumatology and Orthopaedic Surgery, University of Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    J Orthop Res 27:1353-60. 2009
    ..and hyaluronan were immersed in autologous serum and used for covering microfractured full-thickness articular cartilage defects of the sheep (n = 4). Defects treated with microfracture only served as controls (n = 4)...
  82. ncbi The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions
    B Vanwanseele
    Laboratory for Biomechanics, Swiss Federal Institute of Technology Zurich ETHZ, CH 8952 Schlieren, Switzerland
    Osteoarthritis Cartilage 10:408-19. 2002
    The purpose of this paper is to review current data and concepts concerning the effect of immobilization on articular cartilage in animal models. We also evaluate the methods to measure articular cartilage changes in humans.
  83. ncbi Characterization of articular cartilage by combining microscopic analysis with a fibril-reinforced finite-element model
    Petro Julkunen
    Department of Physics, University of Kuopio, Kuopio, Finland
    J Biomech 40:1862-70. 2007
    Load-bearing characteristics of articular cartilage are impaired during tissue degeneration...
  84. ncbi In vitro stimulation of equine articular cartilage proteoglycan synthesis by hyaluronan and carprofen
    S P Frean
    Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts, AL9 7TA, UK
    Res Vet Sci 67:183-90. 1999
    ....
  85. pmc Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
    Allan A Young
    Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia
    Arthritis Res Ther 7:R852-61. 2005
    ..form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage. Along with increased production and activation of degradative enzymes, altered synthesis of cartilage ..
  86. ncbi Meniscal allograft transplantation--part II: alternative treatments, effects on articular cartilage, and future directions
    Paul C Rijk
    Department of Orthopaedic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
    Arthroscopy 20:851-9. 2004
    ..allograft transplantation are evaluated as well as the effect of meniscal allograft transplantation on articular cartilage. Remaining questions and future directions are considered in a final discussion...
  87. pmc Extraction techniques for the decellularization of tissue engineered articular cartilage constructs
    Benjamin D Elder
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Biomaterials 30:3749-56. 2009
    ..However, limited work has been performed with articular cartilage, and no studies have examined the decellularization of tissue engineered constructs...
  88. doi The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results
    Mehmet Asik
    Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey
    Arthroscopy 24:1214-20. 2008
    The purpose of this study was to determine the effectiveness of the microfracture technique in the treatment of full-thickness articular cartilage lesions of the knee.
  89. ncbi Plasma rich in growth factors to treat an articular cartilage avulsion: a case report
    Mikel Sanchez
    Arthroscopic Surgery Unit, USP La Esperanza Clinic, Vitoria Gasteiz, Basque Country, Spain
    Med Sci Sports Exerc 35:1648-52. 2003
    ..This is attributed to the slow delivery of growth factors from harvested platelets that have been activated by endogenous thrombin promoted by the addition of calcium chloride...
  90. doi Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation
    J Rieppo
    Institute of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland
    Osteoarthritis Cartilage 17:448-55. 2009
    ..The present study was designed to reveal changes in the collagen network architecture and collagen content in cartilage during growth and maturation of pigs...
  91. doi Outcomes of full-thickness articular cartilage injuries of the shoulder treated with microfracture
    Peter J Millett
    Steadman Hawkins Clinic and Steadman Hawkins Research Foundation, Vail, CO 81657, USA
    Arthroscopy 25:856-63. 2009
    ..The purpose of this study was to determine whether microfracture provides pain relief and improves shoulder function in patients with chondral defects of the glenohumeral joint...
  92. doi Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques
    Tom Minas
    Cartilage Repair Center, Brigham and Women s Hospital, Harvard Medical School, 850 Boylston Street, Chestnut Hill, MA 02467, USA
    Am J Sports Med 37:902-8. 2009
    ..Common knowledge holds that these treatments do not compromise subsequent cartilage repair procedures with autologous chondrocyte implantation...
  93. ncbi A clinical review of cartilage repair techniques
    G D Smith
    Robert Jones and Agnes Hunt Orthopaedic Hospital, Gobowen, Oswestry, Shropshire SY10 7AG, England, UK
    J Bone Joint Surg Br 87:445-9. 2005
  94. ncbi Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity
    N Jallali
    Department of Plastic Surgery, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
    Osteoarthritis Cartilage 13:614-22. 2005
    ..To test the hypothesis that age-related loss of chondrocytes in cartilage is associated with impaired reactive oxygen species (ROS) homeostasis resulting from reduced antioxidant defence...
  95. ncbi The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage
    W Wilson
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Eindhoven 5600 MB, The Netherlands
    Med Eng Phys 27:810-26. 2005
    b>Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis degeneration of articular cartilage occurs...
  96. ncbi Morphology and phenotype expression of types I, II, III, and X collagen and MMP-13 of chondrocytes cultured from articular cartilage of Kashin-Beck Disease
    Weizhuo Wang
    Department of Orthopedics Surgery, Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
    J Rheumatol 35:696-702. 2008
    ..expression of types I, II, III, and X collagen and matrix metalloproteinase-13 (MMP-13) of chondrocytes from articular cartilage of adult patients with Kashin-Beck Disease (KBD) in vitro to understand the pathogenesis in chondrocytes.
  97. ncbi Aging, articular cartilage chondrocyte senescence and osteoarthritis
    James A Martin
    Department of Orthopaedics, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biogerontology 3:257-64. 2002
    ..of osteoarthritis (OA), the disease characterized by joint pain and loss of joint form and function due to articular cartilage degeneration, is directly correlated with age...
  98. ncbi Sensitivities of medial meniscal motion and deformation to material properties of articular cartilage, meniscus and meniscal attachments using design of experiments methods
    Jiang Yao
    Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA
    J Biomech Eng 128:399-408. 2006
    This study investigated the role of the material properties assumed for articular cartilage, meniscus and meniscal attachments on the fit of a finite element model (FEM) to experimental data for meniscal motion and deformation due to an ..
  99. ncbi The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage
    F Guilak
    Orthopaedic Research Laboratories, Departments of Surgery, Biomedical Engineering, and Mechanical Engineering and Materials Science, Duke University Medical Center, P O Box 3093, 375 MSRB, 27710, Durham, NC, USA
    J Biomech 33:1663-73. 2000
    ..Based on the existing experimental data on the deformation behavior and biomechanical properties of articular cartilage and chondrocytes, a multi-scale biphasic finite element model was developed of the chondrocyte as a ..
  100. doi Prospective evaluation of concurrent meniscus transplantation and articular cartilage repair: minimum 2-year follow-up
    John Paul H Rue
    Department of Orthopaedic Surgery, National Naval Medical Center, Bethesda, Maryland, USA
    Am J Sports Med 36:1770-8. 2008
    Recognition of the symbiotic relationship between the meniscus and articular cartilage is critical to the success of meniscal allograft transplantation...
  101. ncbi Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage
    J DeGroot
    Gaubius Laboratory, TNO Prevention and Health, 2301 CE Leiden, The Netherlands
    Osteoarthritis Cartilage 9:720-6. 2001
    ..OAs) increases with age and coincides with the accumulation of advanced glycation endproducts (AGEs) in articular cartilage, suggesting that accumulation of glycation products may be involved in the development of OA...

Research Grants82

  1. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..of osteoarthritis with a primary focus on the biochemical and biomechanical changes in the knee joint and articular cartilage;3) Acquire background knowledge and technical skills relevant to the development of knee OA including both ..
  2. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..The long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in extracellular matrix proteins...
  3. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ELIZABETH ALICE ERICKSON; Fiscal Year: 2010
    ..species (ROS) have been observed in the cartilage of OA patients and may play a role in the stimulation of articular cartilage extracellular matrix (ECM) degradation...
  4. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Chondrocytes in articular cartilage respond to mechanical and osmotic signals arising from joint loading;however, the cellular mechanisms by ..
  5. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..OA is manifested by degeneration in articular cartilage (initially decreased proteoglycan content, followed by reduced thickness) and damage to subchondral bone (..
  6. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  7. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..disorder in which activated synovial fibroblasts produce chemokines that facilitate the invasion of the articular cartilage and underlying bone by the release of matrix-degrading enzymes...
  8. Identification of the transcriptional regulators of chondrocyte hypertrophy
    ANDREW BRUCE LASSAR; Fiscal Year: 2013
    ..in the hope that this knowledge will lead to the development of reagents that could block this program in articular cartilage and thereby slow the progression of osteoarthritis...
  9. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..OA is characterized by degeneration of articular cartilage of the joints in hands, knees, spine and hips...
  10. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    ..mechanical loading following injury to promote a state of inflammation and matrix degradation in the articular cartilage. We will pursue the following aims: In Aim 1, we will examine the role of a high-fat lard- based diet in ..
  11. BMP2 signaling of the development of osetoarthritis
    Vicki Rosen; Fiscal Year: 2013
    ..factors must be sorted out in order to determine the importance of changing levels of BMP2 signaling in articular cartilage in the pathogenesis of OA...
  12. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..The quantitative MRI (qMRI) technique of T2 mapping developed for articular cartilage imaging is unable to capture the very short T2 values of the meniscus...
  13. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..We hypothesize that there will be significantly more degeneration of the articular cartilage, remaining untorn menisci and subchondral bone during the degenerative phase of the traumatic versus the ..
  14. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    ..Congenital defects, disease and trauma to synovial joints, in particular to the articular cartilage that comprises a joint, are debilitating o billions of people...
  15. Function and Regulation of CD-RAP
    Linda J Sandell; Fiscal Year: 2013
    ..combined to analyze groups of co-expressed genes and define common regulatory domains of genes expressed in articular cartilage. The current proposal will focus on extending these analyses to define transcriptional regulatory networks ..
  16. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..New clinical strategies to improve evaluation, repair, and regeneration of damaged articular cartilage are needed to prevent or delay the onset of disabling pain and OA...
  17. Biomarker of Tissue Tolerance and Behavior in a Rat Model of WMSD
    Mary F Barbe; Fiscal Year: 2013
    ..force (MRLF) and high repetition-high force (HRHF), leads to bone resorption and pathological changes, and articular cartilage damage, and if the mechanism underlying these changes is inflammatory, mechanical overuse, or both...
  18. Lubricin Function in Articulating Joints
    Matthew L Warman; Fiscal Year: 2012
    ..We have demonstrated that lubricin prevents mechanical wear of articular cartilage. Humans and mice that genetically lack lubricin develop precocious cartilage failure and synovial ..
  19. Defining Common Molecular Parameters For Onset and Progression of Osteoarthritis
    Roland Wolkowicz; Fiscal Year: 2010
    ..damage (progression) in OA, but importantly, also to the initiation/onset phase, wherein chondrocytes in articular cartilage leave their natural growth- and differentiation-arrested state...
  20. Sox9-mediated control of chondrogenesis
    VERONIQUE M LEFEBVRE; Fiscal Year: 2013
    ..defects due to cartilage malformations, growth retardations due to growth plate defects in children, and articular cartilage degeneration diseases in adults...
  21. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2013
    ..Our Aims are: (1) To uncover the respective roles of Erg and Fli-1 in joint formation and long-term articular cartilage stabilization;(2) To determine how Erg and Fli-1 regulate PTHrP expression;and (3) To determine if ..
  22. Common mechanisms of Osteoarthritis in three mouse models
    Robert E Seegmiller; Fiscal Year: 2010
    ..following specific aims are proposed: 1) to characterize OA in sedc knee and temporomandibular joint (TMJ) articular cartilage histologically and ultrastructurally;2) to identify common patterns of articular cartilage degeneration ..
  23. Multifunctional Printed Scaffolds for Enhancing Hepatocyte Viability and Function
    Ramille N Shah; Fiscal Year: 2013
    ..D. involving the development of gene-supplemented collagen scaffolds for articular cartilage regeneration at the Massachusetts Institute of Technology and with two years of post-doctoral research ..
  24. Engineering Developmental Microenvironments: Cartilage Formation and Maturation
    Robert L Mauck; Fiscal Year: 2012
    b>Articular cartilage lines the surfaces of joints and transmits the forces generated with loading...
  25. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2009
    ..b>Articular cartilage destruction is a central factor in the pathogenesis of joint diseases, including osteoarthritis (OA) and ..
  26. Mandibular Cartilage Regeneration In Situ by Endogenous Stem Cell Recruitment
    Wendy S Vanden Berg-Foels; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporomandibular joint (TMJ) articular cartilage injuries do not heal, resulting in joint degeneration that interferes with speaking and eating...
  27. Use Of Adipose Derived Stem Cells For Engineering Of Ligament Tissue
    David McAllister; Fiscal Year: 2012
    ..to prevent the associated complications of recurrent instability with subsequent damage to the menisci and articular cartilage. Current treatments for ACL ruptures require the use of grafts for reconstruction because the injured ACL ..
  28. New probes for matrix metalloproteinase 13
    Gregg B Fields; Fiscal Year: 2013
    ..applicant): Osteoarthritis (OA), the most common form of arthritis, is characterized by the destruction of articular cartilage. The main constituents of articular or joint cartilage are type II collagen and various proteoglycans, such ..
  29. ESE 1 a novel transcriptional regulator of cartilage remodeling
    MARY GOLDRING; Fiscal Year: 2009
    ..The absence of MMP-13 protein in the Ese1/Elf3-deficient mouse, and the increased Ese1 expression in the articular cartilage of the cho/+ mouse model of OA compared to wild type mice, further suggests its pivotal role in cartilage ..
  30. Selection of Therapeutic Agents for Articular Cartilage Repair
    Stephen B Trippel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Articular cartilage is the gliding surface of diarthrodial joints. The loss of articular cartilage, through trauma or osteoarthritis, is a major cause of pain and disability...
  31. ESE 1 a novel transcriptional regulator of cartilage remodeling
    Mary B Goldring; Fiscal Year: 2013
    ..The absence of MMP-13 protein in the Ese1/Elf3-deficient mouse and the increased Ese1 expression in the articular cartilage of the cho/+ mouse model of OA compared to wild type mice further suggest its pivotal role in de-regulated ..
  32. Transglutaminase 2 in cartilage formation
    Maria Nurminskaya; Fiscal Year: 2011
    ..However, using MSCs for the articular cartilage repair faces a challenge of generating cells with features of stable chondrocytes which are resistant to ..
  33. Serum microRNAs as biomarkers of post-traumatic osteoarthritis
    Gary J Gibson; Fiscal Year: 2010
    ..Osteoarthritis is a debilitating widespread disease that involves the loss of function of articular cartilage;the smooth bearing surface of our joints...
  34. Oxidative Stress and the Development of Osteoarthritis
    Richard F Loeser; Fiscal Year: 2013
    ..OA) by focusing on mechanisms by which reactive oxygen species (ROS) alter cell signaling in the articular cartilage and meniscus. Oxidative stress results when levels of ROS exceed the anti-oxidant capacity of cells...
  35. Consequences of Mutant COMP Expression and Therapeutic Approaches in Transgenic M
    Jacqueline T Hecht; Fiscal Year: 2013
    ..or reversing the intracellular retention of MT-COMP and 3) characterizing the effect of MT-COMP on articular cartilage morphology and function in mice throughout life...
  36. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2013
    ..b>Articular cartilage destruction is a central factor in the pathogenesis of joint diseases, including osteoarthritis (OA) and ..
  37. Muscle Weakness and Post-Traumatic Knee OA
    Terese L Chmielewski; Fiscal Year: 2011
    ..Through this K01 award, the applicant will gain skills in conducting clinical trials, assessing articular cartilage morphology with magnetic resonance imaging (MRI), and performing biochemical analysis of articular ..
  38. Immune Recognition of Citrullinated Cartilage PG Aggrecan in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Proteoglycan (PG) aggrecan is a major macromolecular component of articular cartilage. PG has been considered a T-cell autoantigen in patients with rheumatoid arthritis (RA), an autoimmune disease of ..
  39. Suppression of MMP-13 Expression in Arthritis by Pomegranate
    Tariq M Haqqi; Fiscal Year: 2013
    ..RELEVANCE: Osteoarthritis (OA) is characterized by high levels of IL-12, excessive production of ROS and articular cartilage degeneration in the affected joints...
  40. Early Detection and Quantification of OA
    Karen A Hasty; Fiscal Year: 2013
    ..fluorescently labeled antibodies (NIF-MabCII) will selectively localize to joints in which the surface of articular cartilage is eroded and CII is exposed...
  41. Intrinsic Repair of the Knee Meniscus
    Farshid Guilak; Fiscal Year: 2011
    ..Damage or loss of the menisci often results in progressive osteoarthritic degeneration of the articular cartilage and other joint tissues, leading to significant pain and disability...
  42. Mechanism of Tgfbr2 in chondroprotection
    Rosa A Serra; Fiscal Year: 2013
    ..of my laboratory is to understand the factors that mediate the development, persistence, and repair of articular cartilage and to identify specific targets for prevention and treatment strategies for osteoarthritis...
  43. Suppression of SHH Expression in Arthritis by Butea monosperma
    Tariq M Haqqi; Fiscal Year: 2013
    ..The articular cartilage will be evaluated macroscopically and histologically...
  44. Flow Perfusion Bioreactor Fabrication of Bioactive Polymer/ECM Hybrid Constructs
    Antonios G Mikos; Fiscal Year: 2013
    ..capable of promoting the repair and regeneration of injured or compromised tissues, such as damaged articular cartilage. Indeed, as cartilage has a limited natural capacity to repair itself, damage to articular cartilage and ..
  45. Chondrogenic composite grafts for the repair of cartilage defects
    Jie Song; Fiscal Year: 2010
    ..provided by applicant): Traumatic injuries and age-related degenerative diseases associated with articular cartilage (AC) can result in significant patient morbidity and lead to the development of osteoarthritis...
  46. STRUCTURE, FUNCTION AND APPLICATION OF METALLOPROTEINASE INHIBITORS IN OSTEOARTHR
    Keith Brew; Fiscal Year: 2013
    ..The hallmark of the disease is the breakdown of articular cartilage by elevated proteinase activities that degrade major extracellular matrix molecules, aggrecans and ..
  47. Regenerating the fibrocartilage spectrum of the TMJ: from disc to condyle
    Kyriacos A Athanasiou; Fiscal Year: 2013
    ..pressure and direct compression stimulation has been shown by our laboratory to have beneficial effects on articular cartilage and fibrocartilage constructs, and we will apply these stimuli individually and in combination to further ..
  48. Biomechanical Regulation of Oxidative Homeostasis in Articular Cartilage
    RITA ISSAM ISSA; Fiscal Year: 2011
    ..The goal of the proposed study is to elucidate the mechanisms by which biomechanical signals regulate articular cartilage homoeostasis via changes in the cellular anti-oxidant defense system and the net oxidative state...
  49. Notch Signaling in Joint Cartilage Maintenance and Arthritis
    Matthew J Hilton; Fiscal Year: 2013
    ..discoveries identifying the Notch signaling effector, RBPjk, as a novel and critical regulator of normal articular cartilage and joint maintenance...
  50. HMGB2 in cartilage homeostasis, aging and osteoarthritis
    Martin K Lotz; Fiscal Year: 2013
    ..Our preliminary studies show that the chromatin protein HMGB2 is exclusively expressed in the SZ of articular cartilage. We examined Hmgb2-/- mice and found more severe OA as compared to wild-type (WT) mice...
  51. The role of the inflammatory response in bone and cartilage changes following non
    BLAINE ANDREW CHRISTIANSEN; Fiscal Year: 2013
    ..provided by applicant): Post-traumatic osteoarthritis (PTOA) is characterized by degeneration of articular cartilage and subchondral bone, and is commonly a long-term consequence of traumatic joint injury, with approximately ..
  52. Genetic Mouse Models of Cartilage Healing
    LINDA J contact SANDELL; Fiscal Year: 2010
    ..Recently, a direct correlation between articular cartilage healing and protection from osteoarthritis (OA) has been demonstrated...
  53. Unlocking transcript diversity via differential analyses of splice graphs
    Jan F Prins; Fiscal Year: 2013
    ..to three well curated RNA-seq datasets on lung cancer pathogenesis, stem cells in leukemia, and equine articular cartilage development and repair (a non-model mammalian organism)...
  54. Driving tissue formation by inductive stem cell sheet technology
    Eben Alsberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is a degenerative disease of articular cartilage affecting millions of people worldwide, including over 70% of people over 65...
  55. Regenerative Elastography: Monitoring Soft Tissue Reconstruction
    Shadi F Othman; Fiscal Year: 2010
    ..applied, cannot be used to study small biological tissues, or to image in vivo thin tissue regions, such as articular cartilage with thickness less than 2 mm and distinct structure in sub millimeter layers...
  56. Transcription Factor NFAT1 Deficiency and Osteoarthritis
    Jinxi Wang; Fiscal Year: 2013
    ..of catabolic cartilage-degrading proteinases and proinflammatory cytokines has been shown to cause articular cartilage degradation...
  57. Relationship of Hip Muscle Group Weakness to Deterioration of the OA Knee by MRI
    Leena Sharma; Fiscal Year: 2012
    ..The equipment, pulse sequences, and quality of the MRI protocol support quantitative assessment of articular cartilage. The results of this study will inform development of physical and rehabilitative therapy for knee OA that ..
  58. Enhanced Tendon Healing through Growth Factor and Cell Therapies
    Stavros Thomopoulos; Fiscal Year: 2013
    ..Others have shown that adult stem cells can enhance healing in extrasynovial tendons, articular cartilage, and other tissues...
  59. Nerve Repair through Muscle Progenitor Cell Transplantation
    Johnny Huard; Fiscal Year: 2013
    ..repair of various tissues of the musculoskeletal system, including skeletal and cardiac muscles, bone and articular cartilage, yet their ability to undergo neurogenic differentiation has not been fully investigated...
  60. CCN proteins in cartilage formation and maintenance
    Karen M Lyons; Fiscal Year: 2013
    ..Similarly, although some CCN proteins are expressed in adult articular cartilage and intervertebral discs (IVDs), their functions in these tissues are unknown...
  61. A crosslinked cartilage-derived matrix for cartilage tissue engineering
    Bradley T Estes; Fiscal Year: 2012
    ..histologically and mechanically in comparison to the biochemical and biomechanical properties of native articular cartilage. Additionally, the overall toxicity and host immunological reaction to the CDM will be evaluated in this ..
  62. TRAINING IN CARTILAGE RESEARCH
    THEODORE RICHARD OEGEMA; Fiscal Year: 2010
    ..interactions via receptors, models for chondrocyte and cartilage culture, differences between human articular cartilage derived from different joints and different regions of cartilage, as well as animal models for degenerative ..
  63. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..and transforming growth factor beta could be a useful agent in the treatment of osteoarthritis to limit articular cartilage degeneration and potentially facilitate its repair...
  64. Perlecan modulates VEGF Bio-Availability in Human Osteoarthritic Cartilage
    RONALD GOMES; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how human articular cartilage derived heparan sulfate proteoglycans bind to and modulate the activity of heparin binding growth factors important for ..
  65. Biologic scaffold prostheses to enhance meniscus repair
    JOE WEINBERG; Fiscal Year: 2009
    ..Meniscal damage or loss often results in progressive osteoarthritic degeneration of the articular cartilage and other joint tissues, leading to significant pain and disability...
  66. Regulated Osteochondrogenesis of Human Mesenchymal Stem Cells Using Gene Delivery
    Antonios Mikos; Fiscal Year: 2009
    Regeneration of articular cartilage damaged either by disease or injury is a complex problem that remains a significant clinical challenge despite extensive orthopaedic research...
  67. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..During the early stages of osteoarthritis, localized lesioning of the articular cartilage layer is a characteristic occurrence...
  68. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The cellular repair response to damaged articular cartilage that has been characterized by traditional light microscopic technology suggests reactivation of the same chondrocyte lineage that ..
  69. ARTICULAR CARTILAGE REPAIR
    Robert Sah; Fiscal Year: 1999
    DESCRIPTION: (Adapted from investigator's abstract) Integrative repair of articular cartilage, defined as the healing of cartilage-cartilage or cartilage-tissue interfaces, is required in a number of orthopaedic conditions and rheumatic ..
  70. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..step, we evaluate the construct maturation, as well as their capacity to preserve the underlying articular cartilage. Methodology: Electrospun scaffolds will be fashioned in a novel tri-polymer electrospinning system we ..
  71. Cartilage Shaping for Biological Resurfacing/Replacement of the TMJ
    Gregory Williams; Fiscal Year: 2009
    ..Severe deterioration of the articular cartilage of the mandibular condyle can occur in advanced cases of TMJD and may necessitate surgical removal via ..
  72. Age-Related Differences in Cartilage OP-1
    Susan Chubinskaya; Fiscal Year: 2005
    Degeneration of articular cartilage occurs with aging and accelerated in osteoarthritis (OA). However, the mechanisms responsible for these changes are currently unknown...
  73. HAPTOTACTIC REPAIR OF THE MENISCUS
    CAHIR MCDEVITT; Fiscal Year: 2002
    ..the menisci play in the general biomedical functioning of the knee joint and the specific protection of articular cartilage. The data in the literature supporting a casual relationship between tears and meniscus and damage to the ..
  74. A Standard Animal Model for Articular Cartilage Repair
    Anthony Ratcliffe; Fiscal Year: 2010
    ..There are a growing number of new technologies and methodologies attempting to address articular cartilage repair, however there is no uniform method of assessing their safety and effectiveness or efficacy...
  75. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ..Our long-term objective is to develop a clinically applicable biologic arthroplasty approach for treating articular cartilage loss due to injury or osteoarthritis in humans...
  76. Gene Transfer of Growth Factors and Receptors as Therap*
    Ernest Terwilliger; Fiscal Year: 2002
    ..and overexpression of three distinct genes, separately as well as in combination, upon the healing of articular cartilage lesions in vivo...
  77. Hybrid Composite Scaffolds for Cartilage Tissue Engineering
    GEOFFREY ERICKSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Damage and subsequent degeneration of articular cartilage in the form of osteoarthritis represents a major health issue globally, and current estimates report that by the year 2020, over 59 million ..
  78. Design and Evaluation of Ultrasound Stimulation Aided Bioreactor Configurations
    Anu Subramanian; Fiscal Year: 2010
    b>Articular cartilage, the avascular tissue that covers the ends of synovial joints and provides articulating joints with a durable, weight-distributing surface, damaged by illness or trauma has little capacity for self-repair...
  79. In Situ Polymerizing Biodendrimer Scaffolds for Articular Cartilage Repair
    ROBERT NASLUND; Fiscal Year: 2006
    ..or known to be biocompatible, that can be custom-designed to provide a unique scaffold appropriate for articular cartilage repair...
  80. AGE RELATED DIFFERENCES IN CARTILAGE PROTEOGLYCANS
    Eugene Thonar; Fiscal Year: 2000
    Aggrecan, the most abundant proteoglycan in articular cartilage, gives the tissue many of its functional properties, including its ability to undergo rapid reversible deformation...
  81. REGULATION OF COLLAGENASE 3 GENE EXPRESSION BY CYTOKINES
    Mahboob Rahman; Fiscal Year: 2002
    ..collagenase-3 gene expression in order to better understand the mechanisms involved in the degradation of articular cartilage in rheumatic diseases such as rheumatoid arthritis (RA) and osteoarthritis ( OA)...
  82. Tissue Engineering of Temporomandibular Joint Cartilage
    STEVEN NICOLL; Fiscal Year: 2004
    ..Given recent evidence for the causative roles of OA in disc displacement, restoration of the TMJ articular cartilage may be a more effective approach to restoring joint function...