Summary: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.

Top Publications

  1. ncbi Recent advances in craniofacial morphogenesis
    Yang Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 235:2353-75. 2006
  2. doi New directions in craniofacial morphogenesis
    Heather L Szabo-Rogers
    Department of Craniofacial Development, King s College London, UK SE1 9RT
    Dev Biol 341:84-94. 2010
  3. ncbi Tissue origins and interactions in the mammalian skull vault
    Xiaobing Jiang
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Biol 241:106-16. 2002
  4. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
  5. doi Modeling of the human skull in EEG source analysis
    Moritz Dannhauer
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04303, Germany
    Hum Brain Mapp 32:1383-99. 2011
  6. ncbi Jaw and branchial arch mutants in zebrafish I: branchial arches
    T F Schilling
    Imperial Cancer Research Fund, London, UK
    Development 123:329-44. 1996
  7. ncbi Neuroanatomy of flying reptiles and implications for flight, posture and behaviour
    Lawrence M Witmer
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA
    Nature 425:950-3. 2003
  8. ncbi Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo
    P H Krebsbach
    Center for Biorestoration of Oral Health, University of Michigan, School of Dentistry, Ann Arbor 48109, USA
    Hum Gene Ther 11:1201-10. 2000
  9. ncbi Use of two-block partial least-squares to study covariation in shape
    F J Rohlf
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Syst Biol 49:740-53. 2000
  10. ncbi The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect
    Satoshi Yoneda
    Masticatory Function Control, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    J Periodontal Res 38:333-42. 2003

Detail Information

Publications325 found, 100 shown here

  1. ncbi Recent advances in craniofacial morphogenesis
    Yang Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 235:2353-75. 2006
    ..Together, these findings will be beneficial for the understanding, treatment, and prevention of human congenital malformations and establish the foundation for craniofacial tissue regeneration...
  2. doi New directions in craniofacial morphogenesis
    Heather L Szabo-Rogers
    Department of Craniofacial Development, King s College London, UK SE1 9RT
    Dev Biol 341:84-94. 2010
    ..These and future studies will improve our understanding of the genetic and environmental influences underlying human craniofacial anomalies...
  3. ncbi Tissue origins and interactions in the mammalian skull vault
    Xiaobing Jiang
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Biol 241:106-16. 2002
    ..expansion of the cerebral hemispheres was accompanied by expansion of the frontal and parietal bones of the skull vault and deployment of the coronal (fronto-parietal) and sagittal (parietal-parietal) sutures as major growth ..
  4. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    ..These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass...
  5. doi Modeling of the human skull in EEG source analysis
    Moritz Dannhauer
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04303, Germany
    Hum Brain Mapp 32:1383-99. 2011
    We used computer simulations to investigate finite element models of the layered structure of the human skull in EEG source analysis...
  6. ncbi Jaw and branchial arch mutants in zebrafish I: branchial arches
    T F Schilling
    Imperial Cancer Research Fund, London, UK
    Development 123:329-44. 1996
  7. ncbi Neuroanatomy of flying reptiles and implications for flight, posture and behaviour
    Lawrence M Witmer
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA
    Nature 425:950-3. 2003
    ..Orientation of the osseous labyrinth relative to the long axis of the skull was different in these two pterosaur species, suggesting very different head postures and reflecting differing ..
  8. ncbi Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo
    P H Krebsbach
    Center for Biorestoration of Oral Health, University of Michigan, School of Dentistry, Ann Arbor 48109, USA
    Hum Gene Ther 11:1201-10. 2000
  9. ncbi Use of two-block partial least-squares to study covariation in shape
    F J Rohlf
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Syst Biol 49:740-53. 2000
    ..Examples are given to show its usefulness in comparing two sets of variables--especially when one or both of the sets of variables are shape variables from a geometric morphometric study...
  10. ncbi The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect
    Satoshi Yoneda
    Masticatory Function Control, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    J Periodontal Res 38:333-42. 2003
    ..Enamel matrix derivative (EMD) has been clinically used to promote periodontal tissue regeneration. The purpose of the present study is to clarify EMD affects on osteoblastic cells and bone regeneration...
  11. pmc Variation of BMP3 contributes to dog breed skull diversity
    Jeffrey J Schoenebeck
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002849. 2012
    ..By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for ..
  12. doi Long-term results following titanium cranioplasty of large skull defects
    Mario Cabraja
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Germany
    Neurosurg Focus 26:E10. 2009
    ..6-10% of hydroxyapatite-based implants require replacement. In this retrospective study of large skull defects, the authors compared computer-assisted design/computer-assisted modeled (CAD/CAM) titanium implants for ..
  13. doi Cephalometric measurements and determination of general skull type of Cavalier King Charles Spaniels
    M J Schmidt
    Department of Veterinary Clinical Sciences, Small Animal Clinic of the Justus Liebig University Giessen, Frankfurter Straße 108, 35392 Giessen, Germany
    Vet Radiol Ultrasound 52:436-40. 2011
    The general skull morphology of the head of the Cavalier King Charles Spaniel (CKCS) was examined and compared with cephalometric indices of brachycephalic, mesaticephalic, and dolichocephalic heads...
  14. pmc Cranial growth and variation in edmontosaurs (Dinosauria: Hadrosauridae): implications for latest Cretaceous megaherbivore diversity in North America
    Nicolás E Campione
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e25186. 2011
    ..A decline in the disparity of dominant megaherbivores in the latest Maastrichtian interval supports the hypothesis that dinosaur diversity decreased immediately preceding the end Cretaceous extinction event...
  15. doi The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2
    A A Sawyer
    Laboratory of Stem Cells and Tissue Repair, Institute of Medical Biology, A STAR, 8A Biomedical Grove, 06 06 Immunos, 138648, Singapore
    Biomaterials 30:2479-88. 2009
  16. pmc A complete skull of an early cretaceous sauropod and the evolution of advanced titanosaurians
    Hussam Zaher
    Museu de Zoologia da Universidade de São Paulo, Sao Paulo, Brazil
    PLoS ONE 6:e16663. 2011
    ..Furthermore, the evolution of their highly-modified skull anatomy has been largely hindered by the scarcity of well-preserved cranial remains...
  17. pmc Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies
    Gillian M Morriss-Kay
    Department of Human Anatomy and Genetics, University of Oxford, UK
    J Anat 207:637-53. 2005
    The mammalian skull vault is constructed principally from five bones: the paired frontals and parietals, and the unpaired interparietal. These bones abut at sutures, where most growth of the skull vault takes place...
  18. pmc Molecular origins of rapid and continuous morphological evolution
    John W Fondon
    Eugene McDermott Center for Human Growth and Development and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Proc Natl Acad Sci U S A 101:18058-63. 2004
    ..transcription factor 2) genes were quantitatively associated with significant differences in limb and skull morphology...
  19. pmc Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance
    Tal Herbsman
    Mood Disorders Program and Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Hum Brain Mapp 30:2044-55. 2009
    ..We also measured the skull-to-cortex distance over the left motor region...
  20. ncbi Basal tyrannosauroids from China and evidence for protofeathers in tyrannosauroids
    Xing Xu
    Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China
    Nature 431:680-4. 2004
    ..One of the specimens also preserves a filamentous integumentary covering similar to that of other coelurosaurian theropods from western Liaoning. This provides the first direct fossil evidence that tyrannosauroids had protofeathers...
  21. ncbi Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging
    Pengcheng Li
    Key Laboratory of Biomedical Photonics of Ministry of Education Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Lett 31:1824-6. 2006 to access the two-dimensional (2D) cerebral blood flow velocity and vessel structure through the intact rat skull. It is demonstrated that LSTCA can significantly suppress the influence of the laser speckle from the stationary ..
  22. ncbi Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model
    Eun Kyoung Pang
    Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:1364-70. 2004
    ..The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-4 (rhBMP-4) dose on local bone formation in a rat calvaria defect model...
  23. doi Thinned-skull cranial window technique for long-term imaging of the cortex in live mice
    Guang Yang
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, Skirball Institute, New York University School of Medicine, New York, New York, USA
    Nat Protoc 5:201-8. 2010
    ..Here we describe in detail a protocol for imaging cortical structures at high optical resolution through a thinned-skull cranial window in live mice using two-photon laser scanning microscopy (TPLSM)...
  24. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ..Neural crest cells that form the vertebrate head skeleton migrate and interact with surrounding tissues to shape the skull, and defects in these processes underlie many human craniofacial syndromes...
  25. ncbi Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
    J Guicheux
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 18:2060-8. 2003
    ..We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression...
  26. doi Cell lineage in mammalian craniofacial mesenchyme
    Toshiyuki Yoshida
    Department of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Mech Dev 125:797-808. 2008
    ..At E13.5 the primordia of these bones lie basolateral to the brain, extending towards the vertex of the skull during the following 4-5 days. We used DiI labelling of the bone primordia in ex-utero E13...
  27. doi Patterns of morphospace occupation and mechanical performance in extant crocodilian skulls: a combined geometric morphometric and finite element modeling approach
    Stephanie E Pierce
    Department of Earth Sciences, University of Bristol, Bristol BS8 1RJ, UK
    J Morphol 269:840-64. 2008
    ..and fossil crocodilians have long been divided into taxonomic and/or ecological groups based on broad patterns of skull shape, particularly the relative length and width of the snout...
  28. pmc Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development
    Chunxi Ge
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
    J Cell Biol 176:709-18. 2007
    ..This work establishes an important in vivo function for the ERK-MAPK pathway in bone that involves stimulation of RUNX2 phosphorylation and transcriptional activity...
  29. doi A complete skull from Dmanisi, Georgia, and the evolutionary biology of early Homo
    David Lordkipanidze
    Georgian National Museum, 3 Purtseladze Street, 0105 Tbilisi, Georgia
    Science 342:326-31. 2013
    ..D4500) that, together with its mandible (D2600), represents the world's first completely preserved adult hominid skull from the early Pleistocene...
  30. doi The Gavialis-Tomistoma debate: the contribution of skull ontogenetic allometry and growth trajectories to the study of crocodylian relationships
    Paolo Piras
    Dipartimento di Scienze Geologiche, Universita Roma Tre, Italy
    Evol Dev 12:568-79. 2010
    ..Here skull allometric trajectories of Tomistoma and Gavialis were contrasted with those of two longirostral crocodylian taxa, ..
  31. pmc First complete sauropod dinosaur skull from the Cretaceous of the Americas and the evolution of sauropod dentition
    Daniel Chure
    Dinosaur National Monument, P O Box 128, Jensen, UT 84035, USA
    Naturwissenschaften 97:379-91. 2010
    ..Here we describe the first complete sauropod skull from the Cretaceous of the Americas, Abydosaurus mcintoshi, n. gen., n. sp., known from 104.46 +/- 0...
  32. doi Dental occlusion in a 260-million-year-old therapsid with saber canines from the Permian of Brazil
    Juan Carlos Cisneros
    Universidade Federal do Piaui, Centro de Ciências da Natureza, Ininga, Teresina, Piaui, Brazil
    Science 331:1603-5. 2011
    ..This discovery provides new insight into the evolution of heterogeneous dentition in therapsids and broadens our understanding of ecological interactions at the end of the Paleozoic...
  33. doi The effect of BMP-2 on the osteoconductive properties of β-tricalcium phosphate in rat calvaria defects
    Eloa R Luvizuto
    Department of Oral Surgery, Medical University of Vienna, Austria
    Biomaterials 32:3855-61. 2011
    ..Our findings also show that the decreased osteoconductive properties of PLA/PGA and CPC cannot be overcome by BMP-2 supplementation in rat calvaria defects...
  34. pmc A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme
    Marie Anne Breau
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 144, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 105:7750-5. 2008
  35. ncbi Were neandertal and modern human cranial differences produced by natural selection or genetic drift?
    Timothy D Weaver
    Department of Anthropology, University of California, One Shields Avenue, Davis, CA 95616, USA
    J Hum Evol 53:135-45. 2007
    ..We conclude that rather than requiring special adaptive accounts, Neandertal and modern human crania may simply represent two outcomes from a vast space of random evolutionary possibilities...
  36. doi Sexing skulls using discriminant function analysis of visually assessed traits
    Phillip L Walker
    Department of Anthropology, University of California, Santa Barbara, California 93106, USA
    Am J Phys Anthropol 136:39-50. 2008
    ..Because of such population differences, discriminant functions like those presented in this paper should be used with caution on populations other than those for which they were developed...
  37. doi Functional implications of dicynodont cranial suture morphology
    Sandra C Jasinoski
    Department of Earth Sciences, University of Bristol, Wills Memorial Building, Bristol BS8 1RJ, UK
    J Morphol 271:705-28. 2010
    ..suture in Oudenodon could have withstood the higher FE-predicted tensile strain in the posterior skull roof...
  38. pmc Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Development 134:2159-69. 2007
  39. doi Electrospun fibers immobilized with bone forming peptide-1 derived from BMP7 for guided bone regeneration
    Young Jun Lee
    Department of Bioengineering, College of Engineering, Hanyang University, Seongdong Gu, Seoul 133 791, Republic of Korea
    Biomaterials 34:5059-69. 2013
    ..24% in the groups implanted with PD-coated PLGA and with BFP1-coated PLGA, respectively. Based on these results, our approach may be a promising tool to develop clinically-applicable bioactive membranes for guided bone regeneration."..
  40. ncbi Dipole location errors in electroencephalogram source analysis due to volume conductor model errors
    B Vanrumste
    Department of Electronics and Information Systems, Ghent University, Belgium
    Med Biol Eng Comput 38:528-34. 2000
    ..EEG) source analysis, due to not incorporating the ventricular system (VS), omitting a hole in the skull and underestimating skull conductivity...
  41. doi Shape, variance and integration during craniogenesis: contrasting marsupial and placental mammals
    A Goswami
    Department of Genetics, Evolution and Environment, University College London, London, UK
    J Evol Biol 25:862-72. 2012
    ..Our results suggest that high integration of the oral region combined with functional constraints for suckling during early postnatal ontogeny may drive the stagnant variance observed in Monodelphis and potentially other marsupials...
  42. doi Patterns of covariation in the masticatory apparatus of hystricognathous rodents: implications for evolution and diversification
    Lionel Hautier
    Museum of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    J Morphol 273:1319-37. 2012
    The mammalian masticatory apparatus is a highly plastic region of the skull. In this study, a quantification of shape variation, the separation of phylogeny from ecology in the genesis of shape brings new insights on the relationships ..
  43. ncbi The conductivity of the human skull: results of in vivo and in vitro measurements
    T F Oostendorp
    Department of Medical Physics and Biophysics, University of Nijmegen, The Netherlands
    IEEE Trans Biomed Eng 47:1487-92. 2000
    The conductivity of the human skull was measured both in vitro and in vivo. The in vitro measurement was performed on a sample of fresh skull placed within a saline environment...
  44. pmc Analyzing taphonomic deformation of ankylosaur skulls using retrodeformation and finite element analysis
    Victoria M Arbour
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e39323. 2012
    ..length to perpendicular height is used as a strain ellipse, which can be used to determine if ankylosaur skull fossils have been dorsoventrally compacted during fossilization and diagenesis...
  45. doi Skull shape evolution in durophagous carnivorans
    Borja Figueirido
    Departamento de Ecología y Geología de la Facultad de Ciencias, Universidad de Malaga, Malaga, Spain
    Evolution 67:1975-93. 2013
    In this article, we investigate convergent evolution toward durophagy in carnivoran skull shape using geometric morphometrics in a sample of living and extinct species...
  46. doi Principles for the virtual reconstruction of hominin crania
    Philipp Gunz
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany
    J Hum Evol 57:48-62. 2009
    ..While there will typically be shape differences among equally plausible reconstructions, these different estimates might still support a single conclusion...
  47. ncbi Custom made cranioplasty prostheses in porous hydroxy-apatite using 3D design techniques: 7 years experience in 25 patients
    G Staffa
    Division of Neurotraumatology, Presidio Ospedaliero Bufalini, Cesena, Italy
    Acta Neurochir (Wien) 149:161-70; discussion 170. 2007
    None of the materials currently used to reconstruct skull defects is fully satisfactory. Their biological and physical properties are very different to those of natural bone...
  48. doi Customised fabricated implants after previous failed cranioplasty
    Raymond C W Goh
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu Shin Street, Kwei Shan, Taoyuan 333, Taiwan
    J Plast Reconstr Aesthet Surg 63:1479-84. 2010
    ..Customised fabricated alloplastic implants provide a safe, accurate and efficient way of restoring normal cranial contours in patients with cranial defects who have had previous failed cranioplasties...
  49. doi Bone morphogenetic protein 2 therapy for craniofacial surgery
    Darren M Smith
    University of Pittsburgh, Division of Plastic Surgery, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 19:1244-59. 2008
  50. doi The evolution of cranial form and function in theropod dinosaurs: insights from geometric morphometrics
    S L Brusatte
    Division of Paleontology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024, USA
    J Evol Biol 25:365-77. 2012
    ..iconic clade of fossil species including Tyrannosaurus and Velociraptor, developed a great diversity of body size, skull form and feeding habits over their 160+ million year evolutionary history...
  51. pmc Modeling skull electrical properties
    R J Sadleir
    The J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Box 116131, Gainesville, FL 32611 6131, USA
    Ann Biomed Eng 35:1699-712. 2007
    Accurate representations and measurements of skull electrical conductivity are essential in developing appropriate forward models for applications such as inverse EEG or Electrical Impedance Tomography of the head...
  52. doi Cranial biomechanics of Diplodocus (Dinosauria, Sauropoda): testing hypotheses of feeding behaviour in an extinct megaherbivore
    Mark T Young
    School of Earth Sciences, University of Bristol, Bristol, BS8 1RJ, UK
    Naturwissenschaften 99:637-43. 2012
    ..Biomechanical modelling, using finite element analysis, was used to examine the performance of the Diplodocus skull. Three feeding behaviours were modelled: muscle-driven static biting, branch stripping and bark stripping...
  53. doi Evaluation of the volumes of cranial cavities in Cavalier King Charles Spaniels with Chiari-like malformation and other brachycephalic dogs as measured via computed tomography
    Martin J Schmidt
    Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus Liebig University, Frankfurter St 108, 35392 Giessen, Germany
    Am J Vet Res 70:508-12. 2009
    ..AND CLINICAL RELEVANCE-Results of this study suggested that descent of the cerebellum into the foramen magnum and the presence of syringohydromyelia in CKCSs are not necessarily associated with a volume reduction in the CF of the skull.
  54. doi Morphological evolution through integration: a quantitative study of cranial integration in Homo, Pan, Gorilla and Pongo
    Nandini Singh
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany
    J Hum Evol 62:155-64. 2012
    ..Thus, despite having very distinct morphologies the way in which the face, basicranium and cranial vault covary is shared among these taxa. These results imply that the pattern of cranial integration among hominoids is conserved...
  55. pmc Shape and mechanics in thalattosuchian (Crocodylomorpha) skulls: implications for feeding behaviour and niche partitioning
    S E Pierce
    University Museum of Zoology, Department of Zoology, University of Cambridge, Cambridge, UK
    J Anat 215:555-76. 2009
    Variation in modern crocodilian and extinct thalattosuchian crocodylomorph skull morphology is only weakly correlated with phylogeny, implying that factors other than evolutionary proximity play important roles in determining crocodile ..
  56. pmc Anatomy and taxonomic status of the chasmosaurine ceratopsid Nedoceratops hatcheri from the upper Cretaceous Lance Formation of Wyoming, U.S.A
    Andrew A Farke
    Raymond M Alf Museum of Paleontology, Claremont, California, United States of America
    PLoS ONE 6:e16196. 2011
    The validity of Nedoceratops hatcheri, a chasmosaurine ceratopsid dinosaur known from a single skull recovered in the Lance Formation of eastern Wyoming, U.S.A., has been debated for over a century...
  57. ncbi Cranial design and function in a large theropod dinosaur
    E J Rayfield
    Department of Earth Sciences, University of Cambridge, UK
    Nature 409:1033-7. 2001
    ..Here we have applied this technique to the long skull of the large carnivorous theropod dinosaur Allosaurus fragilis...
  58. ncbi Plagiocephaly and brachycephaly in the first two years of life: a prospective cohort study
    B Lynne Hutchison
    Department of Paediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Pediatrics 114:970-80. 2004
    ..The objective of this study was to assess the prevalence and natural history of NSP in normal infants in the first 2 years of life and to identify factors that may contribute to the development of NSP...
  59. doi The evolutionary role of modularity and integration in the hominoid cranium
    Philipp Mitteroecker
    Department of Anthropology, University of Vienna, Althanstrasse 14, A 1091 Vienna, Austria
    Evolution 62:943-58. 2008
    ..The dissociation has probably been achieved by evolutionary alterations and by the novel emergence of local factors affecting characteristics that are controlled at the same time by the common factors...
  60. doi Large-scale diversification of skull shape in domestic dogs: disparity and modularity
    Abby Grace Drake
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Am Nat 175:289-301. 2010
    ..We use geometric morphometrics to quantify the diversity of skull shape in 106 breeds of domestic dog, in three wild canid species, and across the order Carnivora...
  61. ncbi BMP signalling in craniofacial development
    Xuguang Nie
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009 Bergen, Norway
    Int J Dev Biol 50:511-21. 2006
    ..BMP signalling is also an important participant for tooth development, regulating early tooth morphogenesis and subsequent odontoblast differentiation. In this review these aspects are discussed in detail with a focus on recent advances...
  62. ncbi Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development
    Ritva Rice
    Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 233:847-52. 2005
    ..Our findings indicate that Foxc1 integrates the Bmp and Fgf signalling pathways independently of Twist or Noggin. This signalling network is essential for the correct patterning and growth of calvarial bones...
  63. pmc Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization
    Yuji Yoshiko
    Department of Oral Growth and Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Mol Cell Biol 27:4465-74. 2007
    ..These results provide new insights into the functional role of osteoblast autonomous P(i) handling in normal bone mineralization and the abnormalities seen in skeletal tissue in hypophosphatemic disorders...
  64. pmc Cranial neural crest cells on the move: their roles in craniofacial development
    Dwight R Cordero
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 155:270-9. 2011
    ..Furthermore, we present recent findings on NCC diseases called neurocristopathies and, in doing so, provide clinicians with new tools for understanding a growing number of craniofacial genetic disorders...
  65. ncbi Facial heights: evolutionary relevance of postnatal ontogeny for facial orientation and skull morphology in humans and chimpanzees
    Markus Bastir
    Department of Paleobiology, Museo Nacional de Ciencias Naturales, CSIC, 28006 Madrid, Spain
    J Hum Evol 47:359-81. 2004
    ..and inferior limits of facial compartments, contribute to the orientation of the viscerocranium in the primate skull. In humans, vertical facial variation is among the main sources of diversity and frequently associated with an ..
  66. ncbi GTF2IRD1 in craniofacial development of humans and mice
    May Tassabehji
    Academic Unit of Medical Genetics, University of Manchester, St Mary s Hospital, Manchester M13 9PL, UK
    Science 310:1184-7. 2005
    ..human microdeletion disorder Williams-Beuren syndrome (WBS); craniofacial imaging reveals abnormalities in both skull and jaws that may arise through misregulation of goosecoid, a downstream target of Gtf2ird1...
  67. pmc Herbivorous ecomorphology and specialization patterns in theropod dinosaur evolution
    Lindsay E Zanno
    Department of Geology, The Field Museum, Chicago, IL 60605, USA
    Proc Natl Acad Sci U S A 108:232-7. 2011
  68. pmc Chronic optical access through a polished and reinforced thinned skull
    Patrick J Drew
    Department of Physics, University of California at San Diego, San Diego, California, USA
    Nat Methods 7:981-4. 2010
    We present a method to form an optical window in the mouse skull that spans millimeters and is stable for months without causing brain inflammation...
  69. ncbi Computer aided design of large-format prefabricated cranial plates
    David Dean
    Department of Neurological Surgery and the Research Institute, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Craniofac Surg 14:819-32. 2003
    ..The authors begin by locating the cranial defect margin on a skull surface image generated from a 3D head CT-scan...
  70. ncbi Thin-plate spline analysis of allometry and sexual dimorphism in the human craniofacial complex
    Antonio Rosas
    Department of Paleobiology, Museo Nacional de Ciencias Naturales, 28006 Madrid, Spain
    Am J Phys Anthropol 117:236-45. 2002
    ..The sex-specific TPS deformation patterns are hypothesized to be associated with sexual differences in body composition and energetic requirements...
  71. ncbi Cranial reconstruction with computer-generated hard-tissue replacement patient-matched implants: indications, surgical technique, and long-term follow-up
    Barry L Eppley
    Division of Plastic Surgery, Indiana University School of Medicine, 702 Barnhill Drive, 3540, Indianapolis, IN 46202, USA
    Plast Reconstr Surg 109:864-71. 2002
    ..Critical attention must be paid, however, to management of the frontal sinus and preexisting bone infection and the quality of the overlying soft-tissue cover...
  72. ncbi Bone morphogenetic protein-3b (BMP-3b) gene expression is correlated with differentiation in rat calvarial osteoblasts
    J Hino
    National Cardiovascular Center Research Institute, Osaka, Fujishirodai, Suita, 565 8565, Japan
    Biochem Biophys Res Commun 256:419-24. 1999
    ..These findings indicate that BMP-3b gene expression is regulated by osteoblastic differentiation and BMP-3b functions in highly differentiated osteoblasts...
  73. doi The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in Escherichia coli
    Ji Hyun Lee
    Department of Dentistry, Hangang Secred Heart Hospital, College of Medicine, Hallym University 94 195 Youngdeungpo dong, Youngdeungpo gu, Seoul 150030, Republic of Korea
    Biomaterials 31:3512-9. 2010
    ..These results showed that ErhBMP-2 was osteoinductive under controlled in vivo conditions. Thus, ErhBMP-2 has definite potential as an alternative to rhBMP-2 produced in a eukaryotic system for clinical use...
  74. ncbi In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
    ..These studies indicate that osteoclast depletion via RANK blockade is an effective method to prevent and reverse wear debris-induced osteolysis without jeopardizing osteogenesis...
  75. pmc P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
    Nattapon Panupinthu
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, London, ON, Canada
    J Cell Biol 181:859-71. 2008
    ..We conclude that P2X7 receptors enhance osteoblast function through a cell-autonomous mechanism. Furthermore, a novel signaling axis links P2X7 receptors to production of LPA and COX metabolites, which in turn stimulate osteogenesis...
  76. ncbi Comparison of cranial ontogenetic trajectories among great apes and humans
    Philipp Mitteroecker
    Institute for Anthropology, University of Vienna, Althanstrasse 14, A 1091 Vienna, Austria
    J Hum Evol 46:679-97. 2004
    ..Pure heterochrony does not sufficiently explain the human craniofacial morphology nor the differences among the African apes...
  77. pmc Beyond the closed suture in apert syndrome mouse models: evidence of primary effects of FGFR2 signaling on facial shape at birth
    Neus Martínez-Abadías
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16803, USA
    Dev Dyn 239:3058-71. 2010
    ..Coronal suture patency shows marked variation that is not strongly correlated with skull dysmorphology...
  78. ncbi Bone histology indicates insular dwarfism in a new Late Jurassic sauropod dinosaur
    P Martin Sander
    Institute of Paleontology, University of Bonn, Nussallee 8, D 53115 Bonn, Germany
    Nature 441:739-41. 2006
    ..and on the basis of bone histology we show it to have been a dwarf species. The fossils, including excellent skull material, come from Kimmeridgian marine beds of northern Germany, and record more than 11 individuals of sauropods ..
  79. pmc A Runx2 threshold for the cleidocranial dysplasia phenotype
    Yang Lou
    Department of Cell Biology, Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    Hum Mol Genet 18:556-68. 2009
    ..Our findings suggest that the range of bone phenotypes in CCD patients is attributable to quantitative reduction in the functional activity of RUNX2...
  80. ncbi Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation
    T Piotrowski
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:345-56. 1996
    ..The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation...
  81. doi Review of fate-mapping studies of osteogenic cranial neural crest in vertebrates
    Joshua B Gross
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 317:389-400. 2008
    ..have witnessed renewed interest in defining the embryonic cell populations that directly contribute to the bony skull. This question lies at the intersection of several important developmental, clinical and evolutionary interests...
  82. ncbi The evolutionary position of turtles revised
    R Zardoya
    Museo Nacional de Ciencias Naturales, Madrid, Spain
    Naturwissenschaften 88:193-200. 2001
    ..of turtles as the only living survivors of the anapsid reptiles (those that lack temporal fenestrae in the skull)...
  83. doi Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation
    Lyndsey Burton
    Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    J Orthop Res 31:73-80. 2013
    ..Our findings identify the NALP3 inflammasome as a critical mediator of orthopedic wear-induced osteolysis and as a viable therapeutic target for the treatment of periprosthetic osteolysis...
  84. ncbi Cranial anatomy of the spade-headed amphisbaenian Diplometopon zarudnyi (Squamata, Amphisbaenia) based on high-resolution X-ray computed tomography
    Jessica Anderson Maisano
    Jackson School of Geosciences, The University of Texas at Austin, Austin, Texas 78712, USA
    J Morphol 267:70-102. 2006
    The skull of the trogonophid amphisbaenian Diplometopon zarudnyi is described from high-resolution X-ray computed tomographic (HRXCT) imagery of a whole museum specimen preserved in ETOH...
  85. doi Accuracy and reliability of linear cephalometric measurements from cone-beam computed tomography scans of a dry human skull
    Mauricio Berco
    Department of Developmental Biology, Harvard School of Dental Medicine, Harvard University, Boston, Mass, USA
    Am J Orthod Dentofacial Orthop 136:17.e1-9; discussion 17-8. 2009
    The purpose of this study was to determine the accuracy and reliability of 3-dimensional craniofacial measurements obtained from cone-beam computed tomography (CBCT) scans of a dry human skull.
  86. doi Direct measurement of the wavelength of sound waves in the human skull
    Carmen L McKnight
    Department of Mechanical Engineering, Dalhousie University, 1360 Barrington Street, Room C 303 Sexton Campus, Halifax, Nova Scotia B3J 1Z1, Canada
    J Acoust Soc Am 133:136-45. 2013
    ..In this regime the relationship between wavelength and frequency is calculated and compared to a number of theories of skull vibration that have been proposed.
  87. doi Influence of skull modeling approaches on EEG source localization
    Victoria Montes-Restrepo
    Faculty of Engineering and Architecture, Medical Image and Signal Processing MEDISIP, iMinds, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium
    Brain Topogr 27:95-111. 2014
    ..In this head model, the skull is of utmost importance due to its complex geometry and low conductivity compared to the other tissues inside the ..
  88. doi Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel
    H Carruthers
    Tay Valley Veterinary Centre, Whitefriars Crescent, Perth, Australia
    J Small Anim Pract 50:394-8. 2009
    ..To investigate the possible association between caudal fossa area and cervical vertebral dimensions and the presence of syringomyelia in cavalier King Charles spaniels...
  89. pmc Spatial packing, cranial base angulation, and craniofacial shape variation in the mammalian skull: testing a new model using mice
    Daniel E Lieberman
    Departments of Anthropology and Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Anat 212:720-35. 2008
    ..The results illustrate the degree to which the cranial base is centrally embedded within the covariation structure of the craniofacial complex as a whole...
  90. pmc The genetics of canine skull shape variation
    Jeffrey J Schoenebeck
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genetics 193:317-25. 2013
    ..In this Perspectives, we discuss the origins of dog skull shapes in terms of history and biology and highlight recent advances in understanding the genetics of canine skull ..
  91. doi Influence of anisotropic conductivity in the skull and white matter on transcranial direct current stimulation via an anatomically realistic finite element head model
    Hyun Sang Suh
    Department of Biomedical Engineering, Kyung Hee University, Yongin, Gyeonggi, Republic of Korea
    Phys Med Biol 57:6961-80. 2012
    ..and electrical tissue properties, in this work, we investigated the influence of anisotropic conductivity in the skull and white matter (WM) on tDCS via a 3D anatomically realistic finite element head model...
  92. pmc Epigenetic control of skull morphogenesis by histone deacetylase 8
    Michael Haberland
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Genes Dev 23:1625-30. 2009
    ..Here we provide evidence that Hdac8 specifically controls patterning of the skull by repressing a subset of transcription factors in cranial neural crest cells...
  93. pmc Cranial neural crest migration: new rules for an old road
    Paul M Kulesa
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Dev Biol 344:543-54. 2010
    ..We propose a model that attempts to unify many complex events that establish the CNCC migratory pattern, and based on this model we integrate information between cranial and trunk neural crest development...
  94. ncbi Simplification as a trend in synapsid cranial evolution
    C A Sidor
    Department of Paleobiology, Smithsonian Institution, Washington, DC 20560, USA
    Evolution 55:1419-42. 2001
    ..I investigated reduction in number of skull and lower jaw bones (through loss or fusion) over approximately 150 million years of premammalian synapsid history...
  95. doi Pervasive genetic integration directs the evolution of human skull shape
    Neus Martínez-Abadías
    Departament de Biologia Animal, Universitat de Barcelona, Barcelona, Spain
    Evolution 66:1010-23. 2012
    ..separate selection pressures or whether they resulted from the inherent morphological integration throughout the skull. In a novel approach to this issue, we combine evolutionary quantitative genetics and geometric morphometrics to ..
  96. pmc Immediate, but not delayed, microsurgical skull reconstruction exacerbates brain damage in experimental traumatic brain injury model
    Loren E Glover
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e33646. 2012
    Moderate to severe traumatic brain injury (TBI) often results in malformations to the skull. Aesthetic surgical maneuvers may offer normalized skull structure, but inconsistent surgical closure of the skull area accompanies TBI...
  97. doi Sex estimation in forensic anthropology: skull versus postcranial elements
    M Katherine Spradley
    Department of Anthropology, Texas State University, 601 University Drive, San Marcos, TX 78666, USA
    J Forensic Sci 56:289-96. 2011
    When the pelvis is unavailable, the skull is widely considered the second best indicator of sex...
  98. ncbi Effects of developmental and functional interactions on mouse cranial variability through late ontogeny
    Katherine Elizabeth Willmore
    Department of Medical Sciences, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    Evol Dev 8:550-67. 2006
    The mammalian skull performs a variety of functions and its growth and development mirrors this complexity. Cranial growth and development have been actively studied for many years...
  99. doi Fossil evidence on origin of the mammalian brain
    Timothy B Rowe
    Jackson School of Geosciences, University of Texas, C1100, Austin, TX 78712, USA
    Science 332:955-7. 2011
    ..The origin of crown Mammalia saw a third pulse of olfactory enhancement, with ossified ethmoid turbinals supporting an expansive olfactory epithelium in the nasal cavity, allowing full expression of a huge odorant receptor genome...
  100. ncbi Skull size and cheek-tooth length in wild-caught and captive-bred chinchillas
    D A Crossley
    Unit of Oral Pathology, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, UK
    Arch Oral Biol 46:919-28. 2001
  101. pmc Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest
    Ankita Das
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002710. 2012
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...

Research Grants73

  1. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..associated with a decreased level of consciousness, amnesia, other neurologic or neuropsychological abnormalities, skull fracture, intracranial lesions, or death...
  2. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
    ..In murine models, we observed that PTU exposure during embryogenesis (E7.5 to 10.5) is associated with skull and cardiac defects, whereas we do not observe malformations in embryos of dams treated with MMI or high doses of ..
  3. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013 sclera, dentinogenesis imperfecta, joint and skin laxity, hearing impairment and/or wormian bones on the skull [1]...
  4. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2013
    ..Patients with MM develop osteolytic bone disease permanently in the skull, ribs, vertebrae, pelvis, and long bones of the limb, characterized by bone pain, pathologic fractures, and ..
  5. Glutamate-Glutamine Metabolism in Primary Human Brain Tumors
    Anne Williamson; Fiscal Year: 2010
    ..concentrations which can kill the surrounding tissue, allowing the tumor to grow within the confined space of the skull. The specific metabolic pathway used by these tumors to generate the released glutamate has not been determined ..
  6. 3D Single Fiber Endoscope for Minimally Invasive Surgeries
    Jason Geng; Fiscal Year: 2013
    ..for minimally invasive surgeries, such as otolaryngology surgeries (access sinus, middle ear, inner ear and skull based surgeries), and eye surgeries and drug placement on optic nerves. Proprietary Information of XIGEN LLC...
  7. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..skeleton of zebrafish, a widely used model organism for understanding conserved features of development of the skull, and human disorders such as cleft palate...
    ..The skull shape in craniosynostosis can not be explained simply by the premature fusion of sutures, but involves widespread ..
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..that include high myopia, vitreoretinal degeneration, retinal detachment and midline defects in bones of the skull;some patients have imaging abnormalities in the brain suggesting defects in neuronal migration...
  10. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..embryo, including melanocytes, most of the peripheral nervous system (neurons and glia), as well as most of the skull and face, including cartilage, bone, and smooth muscle...
  11. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..An additional advantage of RNS for the TS patient is that it is self-contained in the skull and brain and the system contains no tunneled neck connector wire and no chest pacemaker device...
  12. "Gdf6 gene expression and evolution in vertebrates"
    Douglas Mortlock; Fiscal Year: 2009
    ..In mouse, Gdf6 is important for normal development of limb, ear, skull and spine skeletal joints, the larynx, and potentially other structures including the heart...
  13. Delivery of Soluble FGFR3 as a Treatment for Achondroplasia
    Steven C Ghivizzani; Fiscal Year: 2013
    ..Affected children suffer from abnormal long bone development and deformations of the vertebrae and bones in the skull. There is no cure for achondroplasia, and existing treatments only address some of the complications...
  14. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..control and oxidative stress because folate-responsive neural crest cells contribute to the development of the skull and because glycemic control and hypoxia may contribute to CS...
  15. Improved Source Localization for Pediatric Epilepsy
    Damon Hyde; Fiscal Year: 2013
    ..We will examine improved methods for modeling the skull and cerebrospinal fluid regions of the brain using new MR imaging approaches such as ultrashort echo time (UTE) ..
  16. Regulation of Skeletal Growth by Nuclear Retinoid Receptors
    Maurizio Pacifici; Fiscal Year: 2013
    Growth of endochondral skeletal structures in skull, trunk and limbs is governed by the activity of the growth plates where chondrocytes proliferate, undergo maturation and hypertrophy and are replaced by bone...
  17. Studies of Chondroyte Maturation
    Cristina C Teixeira; Fiscal Year: 2010
    ..This tissue is responsible for bone elongation and growth of bones in the base of the skull and the mandibular condyle...
  18. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013 repeated to optimize US transmit parameters now insonating through intervening wet human cadaveric temporal skull bone. Insonation through bone is limited by sound absorption, scattering and phase aberration...
  19. The Role of Leptin in Inflammation-driven Bone Loss
    Urszula T Iwaniec; Fiscal Year: 2013
    ..Finally, determining the precise role of leptin-modulated peripheral and central pathways is expected identify targets to prevent/treat inflammation-driven bone loss. ..
  20. Fibulin-1 Regulation of the DiGeorge Syndrome Pathogenesis Pathway
    WILLIAM SCOTT ARGRAVES; Fiscal Year: 2012
    ..for normal development of the cardiac outflow tract (OFT), pharyngeal glands, cranial nerves and bones of the skull. The developmental anomalies displayed by mice deficient in Fbln1 recapitulate many of the anomalies associated ..
  21. Identification of gene involved in late stage zebrafish craniofacial development
    REBECCA ANN ANDERSON; Fiscal Year: 2013
    ..The skull is formed from endochondral bones, which develop through mineralization of cartilage, and intramembranous bones, ..
  22. Screen for mutations affecting skull and suture formation in zebrafish
    Shannon Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The closure of cranial sutures is a key process during skull morphogenesis. At the edges of the flat bones, which are centers of regulated bone formation, fibrous sutures unite the individual bones...
  23. Skeletal Phenotyping of KOMP Mice
    Dong Guk Shin; Fiscal Year: 2013
    ..She will inject mineralization dyes and harvest the spine, limbs and skull for shipment to UCONN Farmington. At UCONN, Dr...
  24. Cellular and Molecular Mechanisms of Patterned Growth of the Mammalian Skull
    Robert E Maxson; Fiscal Year: 2013
    ..genetic control of patterned growth during the morphogenesis of a complex, multicomponent structure, the mammalian skull vault...
  25. Pediatric Percutaneous Cochlear Implantation Clinical Validation &Implementation
    Robert F Labadie; Fiscal Year: 2012
    ..PCI reduces CI surgery to a single pass of a drill from the lateral skull base to the cochlea...
  26. Regional differences in neural crest and mesodermal derived calvarial bone healin
    Michael T Longaker; Fiscal Year: 2013
    ..The paired parietal frontal bones in the anterior skull are derived from the neural crest and the paired parietal bones, positioned posteriorly, are derived from the ..
    Charles B Kimmel; Fiscal Year: 2013
    ..Zebrafish broadly share basic patterning mechanisms of jaw and skull formation with other vertebrates, including humans...
  28. MicroXCT-200 High Resolution 3D X-ray Microscope
    MOHAMMED PERVEZ AKHTER; Fiscal Year: 2013
    ..lacunar properties, #2 (Subramanian) scaffolding matrix and surface evaluation;#3 (Turner) lacunar properties in skull bone with improved modeling of compression impact...
  29. The regulatory role of Bone morphogenetic protein 1 in suture patency and fusion
    Matthew Harris; Fiscal Year: 2013 applicant): The correct patterning and timing of the fusion of cranial sutures is essential for normal skull development...
  30. Epithelial-mesenchymal interactions in facial patterning
    GAGE D CRUMP; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patterning of the face and skull involves coordinated signaling between the epithelial cells and skeletal-forming mesenchymal cells of the pharyngeal arches...
  31. LRRK2 Mediated HIV1 Tat Induced Microgliosis is Detrimental to Synapses
    JENNA MAE TABOR-GODWIN; Fiscal Year: 2013
    ..after LRRK2 inhibition using cutting-edge techniques, including in vitro microfluidic chambers and in vivo thin-skull two-photon microscopy...
  32. Clinical Validation and Testing of Percutaneous Cochlear Implantation
    Robert F Labadie; Fiscal Year: 2013
    ..PCI reduces CI surgery to a single pass of a drill from the lateral skull surface to the cochlea...
  33. Cranial suture formation in the zebrafish
    Shannon Fisher; Fiscal Year: 2012
    ..for the transcription factor RUNX2 to delayed and incomplete suture closure, demonstrates that the processes of skull and suture formation are sensitive to dosage of genes regulating osteoblast differentiation...
  34. SkyScan 1076 In Vivo Micro-Computed Tomography System
    Timothy M Ryan; Fiscal Year: 2010
    ..The funded NIH projects include: 1) Phenogenetics of Skull and Brain Integration in Craniosynostosis (R01DE018500-02);2) Molecular Mechanisms of Allergic Asthma Development (..
  35. Third International Chordoma Research Workshop: Catalyzing New Advances in Chordo
    EDWARD LES; Fiscal Year: 2011
    ..Lessons learned from neglected and orphaned cancers such as chordoma, a primary malignancy of the base of skull and spine, are revealing new information that can be translated to more common cancers...
  36. mTOR signaling and sporadic chordomas
    Sangyeul Han; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Chordoma is a slow-growing, malignant tumor, which usually occurs in the spine and base of skull. This project is aimed to examine genetic mutation in chordomas and to generate chordoma animal models, and thus ..
  37. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    ..This can be done by using magnetic resonance imaging in patients without the need of opening the skull. Then this group of patients could be treated before aneurysm bursts and cause a severe stroke.
  38. Imaging the Mitochondrial Response to Neural Activity
    Roger J Springett; Fiscal Year: 2010
    ..It could be applied minimally invasively in mice and neonatal rats where the skull is sufficiently thin to be transparent, on rats using a standard thinned skull preparation, on awake non-human ..
  39. A 3-D Interactive Atlas of the Human Skull
    Kevin N Montgomery; Fiscal Year: 2010
    ..This skull database project, which builds upon and is an extension of the Tooth Atlas project, will be the first phase of a ..
  40. Wireless ECoG Recording for Epilepsy Monitoring
    Stuart F Cogan; Fiscal Year: 2013
    ..The ability to close the dura and skull, avoiding wired conduits to the brain, will reduce the risk of morbidity due to infection and reduce cost by ..
  41. Development of Thermoacoustic Tomography Brain Imaging
    Mark A Anastasio; Fiscal Year: 2013
    ..challenge in TAT brain imaging is to compensate for the distortion introduced into the TAT measurement data by the skull. The broad objective of this proposal is to make TAT brain imaging a practical, useful, and highly effective brain ..
  42. Genetic basis of the neural crest deficit in Down syndrome mice
    Randall J Roper; Fiscal Year: 2010
    ..mice are trisomic for orthologs of about half of the genes found on Hsa21 and exhibit DS-like abnormalities of the skull including brachycephaly, hypomorphic midface, and small dysmorphic mandible...
  43. High frequency activity in infants with epilepsy
    JULIA MARIE STEPHEN; Fiscal Year: 2010
    ..coils are much closer to the scalp than the coils of conventional MEG systems (6 vs 20 mm) and the scalp and skull of infants are thin, much weaker neocortical signals are measurable...
  44. Craniofacial Gene Discovery in Mice
    Leah Rae B Donahue; Fiscal Year: 2010
    ..fully penetrant clinical phenotypes and for their potential to be models for human CF disorders including abnormal skull and eye development, and facial clefting...
  45. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ..Mechanical responses from the model (cortical displacement relative to skull and peak cortical tissue strain) are statistically correlated with the actual occurrence of extra- axial ..
    Thomas F DeLaney; Fiscal Year: 2013
    ..for patients with non-small cell lung cancer, liver tumors, pediatric medulloblastoma and rhabdomyosarcoma, spine/skull base sarcomas, and paranasal sinus malignancies...
  47. Perceptions of Social Risk in Medical Child Abuse Evaluation
    Heather T Keenan; Fiscal Year: 2013
    ..will both submit and review cases of three injury types (traumatic brain injury, long-bone fracture, and skull fracture) using a web-based template. Physicians will rate their perceptions of social risk for each injury case...
  48. Nanoparticle-Directed Photothermal Ablation of Primary Brain Tumors guided by Mag
    R Jason Stafford; Fiscal Year: 2012
    ..minimally invasive, percutaneously delivered photothermal therapy may permit treatment of non-resectable deeper or skull-based tumors. PUBLIC HEALTH RELEVANCE: The incidence of brain tumors in the U.S...
  49. Calvarial periosteal afferents in post-traumatic headache
    Dan Levy; Fiscal Year: 2012
    ..can promote the activation of putative nociceptive afferent neurons that innervate the periosteal lining of the skull. Our data also indicate that similar to patients suffering from PTH, head trauma in rats can also lead to ..
  50. Hemorrhage Control During Brain Surgery
    Weiliam Chen; Fiscal Year: 2010
    ..bleeding during brain surgery is of utmost importance, as excessive bleeding within the confined space of the skull can quickly lead to serious debilitating complications and death...
  51. Middle cerebral artery stroke: Non-contrast MR screening of high-risk plaque
    Chun Yuan; Fiscal Year: 2013
    ..will be optimized for fast screening of the entire carotid artery from the arch of aorta to the base of the skull. Protocol performance will be validated against histology in patients scheduled for carotid endarterectomy...
  52. Capacity Building for Decompressive Craniotomy in Colombia
    Juan Carlos Puyana; Fiscal Year: 2013
    ..Decompressive craniectomy (DC) is a neurosurgical procedure in which a large portion of the skull is removed to allow more space for a swelling brain to expand without further increasing ICP...
  53. Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
    Mesut Sahin; Fiscal Year: 2012
    ..Moreover, the brain and the spinal cord experience significant amounts of translation inside the skull and the spinal column...
  54. Novel coatings on titanium implants for the delivery of stem cells
    MARTYN DARBY; Fiscal Year: 2012
    ..Although the gold standard for restoration of the skull is autologous bone, particularly from the removed flap, substitutes are often necessary due to the flap becoming ..
  55. Function of Mesendoderm in Closure of the Anterior Neural Tube
    Jennifer O Liang; Fiscal Year: 2012
    ..anterior neural tube fails to close, it results in a fatal birth defect called anencephaly in which the brain and skull fail to develop...
  56. Computer Modeled Multiportal Approaches to the Skull Base
    Kris Moe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lesions of the anterior and middle skull base are diverse in their etiology and cause significant morbidity due to close proximity to the carotid arteries, brain, orbits, optic nerves and chiasm...
  57. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2012
    ..It is our hypothesis that transcranial sonication using phased array applicators and patient-specific skull information derived from CT scans can better localize ultrasound energy within the brain, and that this will ..
    Wei Hsu; Fiscal Year: 2013
    ..The craniofacial skeleton consists of viscerocranium and neurocranium, which is subdivided into the calvarium/skull vault and chondrocranium/skull base...
  59. Role of neuregulin 1 signaling in cortical maturation and schizophrenia
    Yachi Chen; Fiscal Year: 2013
    ..I propose to use the thinned-skull technique together with two photon microscopy for long term in vivo imaging of dendritic spines in living animals...
    Thomas L Clemens; Fiscal Year: 2013
    ..manipulation of HIF1 levels in mature osteoblasts does not influence the formation of the flat bones of the skull. These results suggest that the mechanisms which couple angiogenesis to osteogenesis are context (skeletal site) ..
  61. A Novel Imaging Informatics Platform for Craniomaxillofacial Surgery
    Xiaobo Zhou; Fiscal Year: 2013
    ..CMF surgery involves the correction of congenital and acquired deformities of the skull and face. Due to the complex nature of the CMF skeleton, it requires extensive presurgical planning...
  62. In Vivo Measurement of Brain Biomechanics
    Philip V Bayly; Fiscal Year: 2013
    ..Three specific aims are proposed: Aim 1: Measure 3D relative motion between the brain and skull, and estimate 3D strain fields in live human and cadaver brains, during mild linear and angular head acceleration...
  63. CSF Clearance of Intracranial Debris from Traumatic Brain Injury
    Cornelius H Lam; Fiscal Year: 2013
    ..Neurosurgeons for decades have recognized the need for control of pressure and mass balance within the skull. The most significant treatment has been the placement of a ventricular catheter which, by draining cerebrospinal ..
    MICHAEL IGNELZI; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Proper skull development is dependent upon complex epithelial-mesenchymal interactions between the developing flat bones of the calvaria, the mesenchymal blastema of the presumptive ..
  65. Wireless Multichannel Electrocorticogram Recording for Epilepsy Monitoring
    Stuart Cogan; Fiscal Year: 2009
    ..The ability to completely close the dura and skull, avoiding wired conduits to the brain, will reduce the risk of morbidity due to infection and reduce cost by ..
    Susan Herring; Fiscal Year: 2007
    ..The mechanical environment influences skull growth at every level from individual cells to gross structure...
    Robert Friesel; Fiscal Year: 2002
    Craniosynostosis, an abnormality of skull development in which the sutures of the growing calvarial bones fuse prematurely, occurs with a frequency of approximately 1 in 2500 live births...
    Stephen Fisher; Fiscal Year: 2006 applicant): The regulation of cell volume is of critical importance to the CNS due to the restrictions of the skull. Brain swelling, which may occur in response to a lowering of plasma osmolarity or during cytotoxic edema, is ..
    Richard Davis; Fiscal Year: 1993
    As the brain is encased within the skull, the space available for a tumor to grow is severely limited before it reaches a size fatal to the patient...
    Yoshio Okada; Fiscal Year: 2004
    ..e. in the area of human neonatal brain research. Unlike the adults, the skull of the infants has fontanels and sutures which may be abnormally large in pathological cases...
    Raymond Koehler; Fiscal Year: 1991
    ..Because of the compliant fetal skull, these forces can cause intracranial pressure (ICP) to greatly exceed amniotic fluid pressure, thereby decreasing ..
  72. Brain Drug Delivery Using Parkinson as a Disease Model
    Victor Yang; Fiscal Year: 2005
    The protection by the bone-structured skull, the lack of targeting or retention specificity, and the presence of the impermeable blood brain barrier (BBB) render the brain the least promising territory for drug intervention...
    J Post; Fiscal Year: 2004
    ..The delineation of the panoply of genes involved in causing craniosynostosis will enhance our understanding of these diseases and suggest new therapeutic strategies. ..