bone matrix

Summary

Top Publications

  1. ncbi Matrix vesicles and calcification
    H Clarke Anderson
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 2017 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
    Curr Rheumatol Rep 5:222-6. 2003
  2. ncbi Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix
    Bo Han
    Tissue Engineering Laboratory, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Orthop Res 21:648-54. 2003
  3. ncbi Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    Masato Igarashi
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Mol Histol 35:3-10. 2004
  4. ncbi Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide
    Bing Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    J Biomed Mater Res A 80:428-34. 2007
  5. pmc Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone
    M Wendel
    Department of Cell and Molecular Biology, University of Lund, S 221 00 Lund, Sweden
    J Cell Biol 141:839-47. 1998
  6. pmc Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst
    Claudia Di Bella
    Department of Oncology Orthopaedic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Orthop Relat Res 468:3047-55. 2010
  7. ncbi Enhanced guided bone regeneration with a resorbable chamber containing demineralized bone matrix
    Roberto Giardino
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, University of Bologna, Bologna, Italy
    J Trauma 52:933-7. 2002
  8. pmc Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up
    Kivanc Topuz
    GATA Haydarpasa Egitim Hastanesi, Norosirurji Servisi, 34668 Istanbul, Turkey
    Eur Spine J 18:238-43. 2009
  9. doi Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells
    Cyril Thouverey
    Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    J Proteomics 74:1123-34. 2011
  10. ncbi Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects
    Sara A Bender
    Private Practice, Frisco, TX, USA
    J Periodontol 76:768-77. 2005

Research Grants

  1. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2010
  2. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2010
  3. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
  4. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
  5. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
  6. MATRIX PROTEIN/INTEGRIN MEDIATED OSTEOCLAST REGULATION
    Keith Hruska; Fiscal Year: 1999
  7. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    Sarah L Dallas; Fiscal Year: 2010
  8. BONE MATRIX AND BONE RESORPTION
    PAUL ODGREN; Fiscal Year: 2006
  9. BONE MATRIX AND BONE RESORPTION
    PAUL ODGREN; Fiscal Year: 2009
  10. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2010

Detail Information

Publications309 found, 100 shown here

  1. ncbi Matrix vesicles and calcification
    H Clarke Anderson
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 2017 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
    Curr Rheumatol Rep 5:222-6. 2003
    ..In diseases such as osteoarthritis, crystal deposition arthritis, and atherosclerosis, MVs initiate pathologic calcification, which, in turn, augments disease progression...
  2. ncbi Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix
    Bo Han
    Tissue Engineering Laboratory, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Orthop Res 21:648-54. 2003
    A sensitive, rapid, reliable and quantitative method to check the bone forming potential of demineralized bone matrix (DBM) has been developed...
  3. ncbi Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    Masato Igarashi
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Mol Histol 35:3-10. 2004
    ..Thus, it is likely that Dex may promote osteoblastic differentiation and mineralization of FRCC by inducing the expression of Cbfa1 and Osx genes in vitro...
  4. ncbi Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide
    Bing Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    J Biomed Mater Res A 80:428-34. 2007
    ..Bone filling materials are important in bone tissue restoration. In this study, the demineralized bone matrix (DBM) was activated with the engineering human bone morphogenetic protein-2 (BMP-2)...
  5. pmc Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone
    M Wendel
    Department of Cell and Molecular Biology, University of Lund, S 221 00 Lund, Sweden
    J Cell Biol 141:839-47. 1998
    ..The binding appears to be mediated by the integrin alphavbeta3, since this was the only integrin isolated by osteoadherin affinity chromatography of surface-iodinated osteoblast extracts...
  6. pmc Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst
    Claudia Di Bella
    Department of Oncology Orthopaedic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Orthop Relat Res 468:3047-55. 2010
    ..Various treatments have been proposed but there is no consensus regarding the best procedure...
  7. ncbi Enhanced guided bone regeneration with a resorbable chamber containing demineralized bone matrix
    Roberto Giardino
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, University of Bologna, Bologna, Italy
    J Trauma 52:933-7. 2002
    ..The injection of bone marrow stem cells into the chamber had proven to enhance bone regeneration...
  8. pmc Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up
    Kivanc Topuz
    GATA Haydarpasa Egitim Hastanesi, Norosirurji Servisi, 34668 Istanbul, Turkey
    Eur Spine J 18:238-43. 2009
    ..To achieve fusion PEEK cages packed with demineralized bone matrix mixed with autologous blood were used...
  9. doi Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells
    Cyril Thouverey
    Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    J Proteomics 74:1123-34. 2011
    ....
  10. ncbi Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects
    Sara A Bender
    Private Practice, Frisco, TX, USA
    J Periodontol 76:768-77. 2005
    Demineralized bone matrix (DBX) paste and putty are particulate demineralized bone matrices in a 2% or 4% hyaluronate carrier, respectively...
  11. ncbi Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase
    W Tesch
    Ludwig Boltzmann Institute of Osteology 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    J Bone Miner Res 18:117-25. 2003
    ..Also, immunolabeling of osteopontin (OPN) revealed an abnormal distribution pattern of the protein within the bone matrix. Whereas in the wild-type animals OPN was predominantly observed in cement and reversal lines, in the null ..
  12. doi Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function
    Anke Bentmann
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    J Bone Miner Res 25:706-15. 2010
    The bone matrix is composed mostly of collagen, but the initial and continuous presence of fibronectin was found to be crucial for collagen matrix integrity in vitro...
  13. ncbi Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition
    D Miao
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3A 1A1
    Endocrinology 142:926-39. 2001
    ..contributes to the pathogenesis of osteomalacia, we examined the abnormalities of mineralization, Phex, and bone matrix protein expression occurring in Hyp mice in vivo and in ex vivo bone marrow cell cultures...
  14. ncbi Bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro
    Elerin Kärner
    Center for Oral Biology, Institute of Odontology, Karolinska Institutet, SE 141 04 Stockholm, Sweden
    Stem Cells Dev 16:39-52. 2007
    b>Bone matrix production and mineralization involves sophisticated mechanisms, including the initial formation of an organic extracellular matrix into which inorganic hydroxyapatite crystals are later deposited...
  15. ncbi Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
    ..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
  16. pmc Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition
    Hayden William Courtland
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Calcif Tissue Int 83:342-53. 2008
    ..are therefore able to differentially modulate the composition of their bone mineral and the maturity of their bone matrix in conjunction with tissue-level mechanical properties...
  17. pmc A comparison of commercially available demineralized bone matrix for spinal fusion
    Jeffrey C Wang
    Department of Orthopaedics and Traumatology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Eur Spine J 16:1233-40. 2007
    ..the available grafting material as well as to increase spinal fusion rates, the utilization of a demineralized bone matrix (DBM) as a graft extender or replacement is common...
  18. ncbi Staphylococcus aureus adhesion to bone matrix and bone-associated biomaterials
    M C Hudson
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    FEMS Microbiol Lett 173:279-84. 1999
    ..The bacterium expresses several adhesins that facilitate bacterial binding to the bone matrix and to bone implant biomaterials coated with host plasma constituents. The relevant S...
  19. pmc Attachment of osteocyte cell processes to the bone matrix
    L M McNamara
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY, USA
    Anat Rec (Hoboken) 292:355-63. 2009
    ..To date the nature of this attachment is not understood. Osteocytes are embedded in mineralized bone matrix, but maintain a pericellular space (50-80 nm) to facilitate fluid flow and transport of metabolites...
  20. ncbi Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity
    Y Takeuchi
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan
    J Biol Chem 269:32634-8. 1994
    ..of distribution and actions of transforming growth factor (TGF)-beta in bone, TGF-beta 1 binding to extracted bone matrix proteins and the influence of such binding on TGF-beta 1 actions were examined...
  21. ncbi Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2
    Bing Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100080, China
    Biomaterials 28:1027-35. 2007
    ..When demineralized bone matrix (DBM) impregnated with BMP2-h was implanted subcutaneously in rats, homogeneous bone formation was observed...
  22. ncbi Donor age and gender effects on osteoinductivity of demineralized bone matrix
    Kathy Traianedes
    Osteotech, Inc, 51 James Way, Eatontown, New Jersey 07724, USA
    J Biomed Mater Res B Appl Biomater 70:21-9. 2004
    Allogeneic demineralized bone matrix (DBM) has been used extensively as a clinical graft material because of its inherent osteoinductive and osteoconductive properties...
  23. ncbi Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix
    Satoshi Takikawa
    Department of Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biomed Mater Res A 65:37-42. 2003
    In the United States, demineralized bone matrix (DBM) is considered a transplantable tissue and therefore is regulated primarily by the American Association of Tissue Banks...
  24. doi The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity
    Bo Han
    Department of Surgery, University of Southern California, 1840 North Soto Street EDM 191, Los Angeles, CA 90032, USA
    J Bone Joint Surg Am 91:1459-70. 2009
    Demineralized bone matrix is an osteoinductive and osteoconductive material that is often used in orthopaedic surgery to induce bone formation...
  25. ncbi Demineralized bone matrix and spinal arthrodesis
    Kenneth J H Lee
    Department of Orthopaedic Surgery, University of California at Los Angeles, School of Medicine, 1250 16th Street, 7th Floor, Tower 745, Santa Monica, CA 90404, USA
    Spine J 5:217S-223S. 2005
    ..One such alternative is demineralized bone matrix (DBM)...
  26. ncbi The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model
    Yu Po Lee
    Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA 90095 7036, USA
    J Spinal Disord Tech 18:439-44. 2005
    ..Currently, there are a number of different commercially available demineralized bone matrix (DBM) products available that have been prepared by different methods and have different carriers...
  27. pmc FIAT represses bone matrix mineralization by interacting with ATF4 through its second leucine zipper
    Vionnie W C Yu
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    J Cell Biochem 105:859-65. 2008
    ..This structure-function analysis reveals that FIAT interacts with ATF4 and modulates its activity through its second leucine zipper motif...
  28. doi The enhanced modulation of key bone matrix components by modified Titanium implant surfaces
    M R Khan
    Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London WC1X 8LD, UK
    Bone 50:1-8. 2012
    ..05). These findings suggest that modified Ti surfaces induce an enhancement in osteogenic commitment and differentiation, which likely underlie the deposition of more stable bone matrix early in the healing process in vivo.
  29. ncbi PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation
    Michael Thorwarth
    Department of Oral and Maxillofacial Surgery Plastic Surgery, University of Jena, Erlanger Allee 101, D 07747 Jena, Germany
    Bone 38:30-40. 2006
    ..formation after filling defined defects of the frontal skull with autogenous bone or a deproteinized bovine bone matrix (DBBM) in combination with platelet-rich plasma (PRP)...
  30. ncbi Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone
    Xu Ming Dai
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Bone Miner Res 19:1441-51. 2004
    ..We therefore examined the micro- and ultrastructure of the developing bones of osteoclast-deficient CSF-1R-nullizygous mice (Csf1r(-/-) mice)...
  31. ncbi Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix
    Yanchun Liu
    Department of Medicinal Chemistry and Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way Suite 205, Salt Lake City, Utah, 84108, USA
    J Orthop Res 24:1454-62. 2006
    ..of Carbylan-GSX, a crosslinked synthetic extracellular matrix (ECM), were used to deliver human demineralized bone matrix (DBM) in a rat femoral defect model...
  32. ncbi Safety and efficacy of commercially available demineralised bone matrix preparations: a critical review of clinical studies
    Georgios I Drosos
    Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece
    Injury 38:S13-21. 2007
    Demineralised bone matrix (DBM), a form of allograft, possesses the properties of osteoinductivity and osteoconductivity...
  33. ncbi Histologic analysis of implant sites after grafting with demineralized bone matrix putty and sheets
    D P Callan
    Osteotech, Inc, 51 James Way, Eatontown, NJ 07724, USA
    Implant Dent 9:36-44. 2000
    ..Conflicting reports concerning the osteoinductivity of demineralized bone matrix (DBM) and historical use of synthetic bone graft substitutes has limited the use of DBM in oral and ..
  34. ncbi The effect of demineralized bone matrix-calcium sulfate with vancomycin on calcaneal fracture healing and infection rates: a prospective study
    Christopher Bibbo
    Department of Orthopaedic Surgery, Marshfield Clinic, 1000 North Oak Avenue, WI 54449, USA
    Foot Ankle Int 27:487-93. 2006
    ..We hypothesized that human demineralized bone matrix (DBM) calcium sulfate (CaSO(4)) might act as a reasonable alternative to autograft in calcaneal fractures...
  35. ncbi Restoration of bone defect and enhancement of bone ingrowth using partially demineralized bone matrix and marrow stromal cells
    Hsin Nung Shih
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chang Gung University, No 5, Fu Hsing Street, Kwei Shan, Tao Yuan 333, Taiwan
    J Orthop Res 23:1293-9. 2005
    This study aimed to investigate the capability of combining marrow stromal cells (MSC) and partially demineralized bone matrix (PDBM) to fill bone defect and enhance bone ingrowth using a canine non-weight-bearing gap model.
  36. ncbi GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 1: histologic results
    Paul A Fugazzotto
    Int J Periodontics Restorative Dent 23:361-9. 2003
    ..13% of the core biopsy volume. Bone regeneration was evident in all specimens...
  37. pmc Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment
    Rachel F Cox
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e41679. 2012
    ..The expression of several bone matrix proteins were monitored throughout the process of mineralization and increased expression of collagen type 1 ..
  38. doi Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone
    Dario Fortunati
    Department of Biochemistry, Institute of Basic Medical Sciences, PO Box 1112 Blindern, University of Oslo, N 0317 Oslo, Norway
    Matrix Biol 29:594-601. 2010
    ..In conclusion, the present study provides novel observations related to the expression, distribution and regulation of periostin in bone cells and extracellular matrix...
  39. pmc Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo
    Thomas Meury
    Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada
    Mol Cell Biol 30:43-53. 2010
    ..The reduced quantity of bone matrix in S43A mutant bones was mineralized faster, as demonstrated by the significantly reduced mineralization lag ..
  40. ncbi Vascular endothelial growth pattern during demineralized bone matrix induced osteogenesis
    A B Rabie
    Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong
    Connect Tissue Res 36:337-45. 1997
    ..of the current study was to determine the timely ingrowth of blood vessels associated with demineralized bone matrix (DMB) induced osteogenesis...
  41. ncbi Safety and efficacy of use of demineralised bone matrix in orthopaedic and trauma surgery
    Haralampos T H Dinopoulos
    University of Leeds, Academic Department of Trauma and Orthopaedics, School of Medicine, St James s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UK
    Expert Opin Drug Saf 5:847-66. 2006
    Demineralised bone matrix (DBM) acts as an osteoconductive, and possibly as an osteoinductive, material. It is widely used in orthopaedic, neurosurgical, plastic and dental areas...
  42. ncbi DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center for Environment and Health, 85764 Munich Neuherberg, Germany
    Nat Genet 38:1248-50. 2006
    ..4q21 and identified homozygous mutations in DMP1 (dentin matrix protein 1), which encodes a non-collagenous bone matrix protein expressed in osteoblasts and osteocytes...
  43. ncbi Commercially available demineralized bone matrix compositions to regenerate calvarial critical-sized bone defects
    Tahsin Oguz Acarturk
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh, PA, USA
    Plast Reconstr Surg 118:862-73. 2006
    Demineralized bone matrix products are often used by surgeons to regenerate bone. Several different types of carriers have been combined with demineralized bone matrix to improve clinical handling and surgical outcome...
  44. ncbi [Inhibitory effect of bone sialoprotein silencing on the adhesion ability of breast cancer cells to bone matrix]
    Li Wang
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China
    Sheng Wu Gong Cheng Xue Bao 27:233-9. 2011
    ..research mainly to explore the effect of bone sialoprotein (BSP) silence by siRNA on the adhesion ability to bone matrix of bone-seeking breast cancer cells (MDA-MB-231BO)...
  45. ncbi A cyclo peptide activates signaling events and promotes growth and the production of the bone matrix
    S Pallu
    INSERM U 577, Université Bordeaux Victor Segalen, Bordeaux 2, 33076 Bordeaux Cedex, France
    Peptides 24:1349-57. 2003
    ....
  46. doi Feasibility of demineralized bone matrix for craniomaxillofacial contour restoration
    Tolga Eryilmaz
    Department of Plastic, Reconstructive and Aesthetic Surgery, Gazi University Faculty of Medicine, Ankara, Turkey
    J Craniofac Surg 22:1888-92. 2011
    Demineralized bone matrix (DBM) could be a good alternative for craniomaxillofacial contour restoration, especially in perialar, malar, temporal, and frontal regions...
  47. pmc Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells
    Shingo Maeda
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo
    EMBO J 23:552-63. 2004
    Transforming growth factor-beta (TGF-beta), one of the most abundant cytokines in bone matrix, has positive and negative effects on bone formation, although the molecular mechanisms of these effects are not fully understood...
  48. doi Demineralized bone matrix in bone repair: history and use
    ELLIOTT GRUSKIN
    Synthes USA, 1302 Wrights Lane East, West Chester, PA 19380, USA
    Adv Drug Deliv Rev 64:1063-77. 2012
    Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms...
  49. doi Core decompression combined with implantation of a demineralised bone matrix for non-traumatic osteonecrosis of the femoral head
    L Helbig
    Department für Orthopädie, Unfallchirurgie und Paraplegiologie, Universitätsklinik Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany
    Arch Orthop Trauma Surg 132:1095-103. 2012
    ..This study evaluated patients after core decompression combined with an augmentation by a demineralised bone matrix, and particularly aimed to report long-term conversion rates to total hip replacement (THR).
  50. ncbi Use of demineralized bone matrix in ankle/hindfoot fusion
    David B Thordarson
    Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angles, CA 90033, USA
    Foot Ankle Int 24:557-60. 2003
    Sixty-three patients who underwent complex ankle or hindfoot fusion had demineralized bone matrix placed in their fusion site to stimulate fusion...
  51. doi Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization
    Lei Chen
    Biotechnology Research Center Hubei Province Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002, PR China
    Biomacromolecules 10:3193-8. 2009
    In previous studies, we have described the use of demineralized bone matrix (DBM) as a carrier for the localized delivery system of growth factors in vitro and in vivo...
  52. ncbi Acidic bone matrix proteins and their roles in calcification
    Ryuichi Fujisawa
    Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Hokkaido University, N13W7, Sapporo, Japan 080 8586
    Front Biosci (Landmark Ed) 17:1891-903. 2012
    ..Some of these acidic matrix proteins are immobilized on the collagen fibrils and induce nucleation of hydroxyapatite crystals. They can also modulate crystal shape by adsorption on a specific face of the crystals...
  53. pmc Bone matrix osteonectin limits prostate cancer cell growth and survival
    Kristina Kapinas
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Matrix Biol 31:299-307. 2012
    ..To determine how bone matrix osteonectin affects the behavior of prostate cancer cells, we modeled prostate cancer cell-bone interactions ..
  54. ncbi Low oxygen tension enhances chondroinduction by demineralized bone matrix in human dermal fibroblasts in vitro
    Shuichi Mizuno
    Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Cells Tissues Organs 180:151-8. 2005
    ..In sum, hypoxia enhanced cartilage matrix accumulation by hDFs cultured with DBP. These defined conditions can optimize the use of dermal fibroblasts for cartilage tissue engineering...
  55. ncbi Efficacy of composite allograft and demineralized bone matrix graft in treating tibial plateau fractures with bone loss
    Justin T Newman
    Department of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock St, Denver, CO 80204, USA
    Orthopedics 31:649. 2008
    ..We hypothesized a standardized protocol of internal fixation augmented with a mixture of demineralized bone matrix and corticocancellous allograft chips would result in high healing rates with minimal subsidence...
  56. pmc In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption
    X Neil Dong
    Department of Health and Kinesiology, The University of Texas at Tyler, Tyler, TX 75799, USA
    Bone 49:174-83. 2011
    ..and elderly (76±4years old) groups were examined to determine the spatial-temporal distribution of AGEs in bone matrix and its effect on bone resorption activities by directly culturing osteoclastic cells on bone slices...
  57. pmc Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone
    Elizabeth Miller
    Musculoskeletal Integrity Program, Research Division, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA
    Calcif Tissue Int 81:206-14. 2007
    ..To investigate the bone matrix properties, tensile tests combined with geometric analyses were conducted on demineralized femora...
  58. ncbi Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice
    Ryszard Galus
    Chair and Department of Histology and Embryology, Center for Biostructure Research, Medical University in Warsaw, Chałubińskiego 5, PL 02 004 Warsaw, Poland
    Pharmacol Rep 58:443-7. 2006
    ..HO was induced by implantation of rat-derived demineralized bone matrix (DBM) into intramuscular pockets in CFW mice. Mice in the experimental groups received fluvastatin at 3...
  59. ncbi The ratio of osteocytic incorporation to bone matrix formation in femoral neck cancellous bone: an enhanced osteoblast work rate in the vicinity of hip osteoarthritis
    G R Jordan
    Bone Research Group MRC, Department of Medicine, University of Cambridge Clinical School, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Calcif Tissue Int 72:190-6. 2003
    ..One possible approach to strengthening bone in osteoporosis might be to enhance the effective lifespan of the osteoblast by modulating TGFb-related pathway activity in its local environment...
  60. ncbi Intrinsic axial vascularization of an osteoconductive bone matrix by means of an arteriovenous vascular bundle
    Elias Polykandriotis
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Germany
    Plast Reconstr Surg 120:855-68. 2007
    ..The authors also evaluated corrosion cast and intravital magnetic resonance angiography as methods for monitoring and quantifying the angiogenic response...
  61. ncbi Effects of fixation and decalcification on the immunohistochemical localization of bone matrix proteins in fresh-frozen bone sections
    Akihiro Hosoya
    Department of Oral Histology, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri, Nagano, 399 0781, Japan
    Histochem Cell Biol 123:639-46. 2005
    To examine the stability of bone matrix proteins for crystal dislocation, the immunolocalization of type I collagen, bone sialoprotein, and osteopontin was investigated during different stages of fixation and decalcification...
  62. ncbi Anisotropy of demineralized bone matrix under compressive load
    Hanna Trebacz
    Department of Biophysics, Medical University of Lublin
    Acta Bioeng Biomech 13:71-6. 2011
    ..Both secant modulus of elasticity and AE parameters were significantly higher in T direction than in L direction, which is attributed to shifting and separation of lamellae of collagen fibrils and lamellae in bone matrix.
  63. doi Autologous bone marrow grafting combined with demineralized bone matrix improves consolidation of docking site after distraction osteogenesis
    Ippokratis Hatzokos
    1st Orthopaedic Department of Aristotle University of the Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Bone Joint Surg Am 93:671-8. 2011
    ..We further sought to clarify whether the application of autologous bone marrow cells combined with demineralized bone matrix would substantially improve docking site consolidation.
  64. ncbi The expression of bone matrix protein mRNAs around beta-TCP particles implanted into bone
    K Ohsawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res 52:460-6. 2000
    ..The latter cells may be macrophages and reflect foreign body reactions. Expression of these OPN mRNAs induced by implantation of beta-TCP may play a role in bone formation on the materials and in determining their biocompatibility...
  65. doi Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells
    Ethel H Alcantara
    Department of Food Science and Nutrition, Andong National University, Andong, KyungBook, South Korea
    J Nutr Biochem 22:1055-63. 2011
    ..The medium and cellular levels of Type 1 collagen and alkaline phosphatase (ALP), both of which are major bone matrix proteins, increased within the low range of diosgenin concentration (>0-3 μM), and this pattern was further ..
  66. ncbi Osteoinductivity of demineralized bone matrix in immunocompromised mice and rats is decreased by ovariectomy and restored by estrogen replacement
    J McMillan
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332, USA
    Bone 40:111-21. 2007
    The osteoinduction potential of human demineralized bone matrix (DBM) in females with low estrogen (E2) is unknown...
  67. pmc Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells
    Jian Zhang
    Arkansas Children s Nutrition Center, Slot 512 20B 15 Children s Way, Little Rock, AR 72202, USA
    Age (Dordr) 35:807-20. 2013
    Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation...
  68. ncbi BAPN dose dependence of mature crosslinking in bone matrix collagen of rabbit compact bone: corresponding variation of sonic velocity and equatorial diffraction spacing
    S Lees
    Bioengineering Department, Forsyth Dental Center, Boston, MA 02115
    Connect Tissue Res 24:95-105. 1990
    Crosslinking density in demineralized bone matrix collagen was found to depend on the beta-aminopropionitrile (BAPN) dose level for compact bone from rabbit femurs...
  69. ncbi Early expression of bone matrix proteins in osteogenic cell cultures
    Paulo Tambasco de Oliveira
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dentistry, Universite de Montreal, QC, Canada
    J Histochem Cytochem 51:633-41. 2003
    ..These results indicate that an important proportion of cells used for plating contain BSP and OPN, a situation that should be taken into consideration in experimental analyses of osteoblast activity in vitro...
  70. ncbi Osseous healing using injectable calcium sulfate-based putty for the delivery of demineralized bone matrix and cancellous bone chips
    Thomas M Turner
    Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Ill, USA
    Orthopedics 26:s571-5. 2003
    Three formulations of injectable calcium sulfate-based putties containing demineralized bone matrix (DBM), 50% DBM/50% cancellous bone (CB) chips, and 30% DBM/70% CB were studied in canines...
  71. doi Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts
    Beatrice Tonnarelli
    Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res A 89:687-96. 2009
    ..cartilaginous (hyaluronan-based scaffold), and plastic substrate culture on human osteoblast proliferation, bone matrix molecule, and inflammatory factor expression...
  72. doi Effect of hyperbaric oxygen on demineralized bone matrix and biphasic calcium phosphate bone substitutes
    Ahmed Jan
    Chief Resident in Oral and Maxillofacial Surgery and Anesthesia, University of Toronto, Toronto, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:59-66. 2010
    ..effect of hyperbaric oxygen (HBO) on the healing of critical-sized defects that were grafted with demineralized bone matrix (DBM) combined with Pluronic F127 (F127) to form a gel or putty, or a commercially available biphasic calcium ..
  73. ncbi Expression of bone matrix protein mRNAs by primary and cloned cultures of the regenerative phenotype of human periodontal fibroblasts
    S Ivanovski
    Department of Dentistry, University of Queensland, Brisbane, Australia
    J Dent Res 80:1665-71. 2001
    ..This study has identified markers that correlate with the known ability of periodontal ligament and regenerating tissue-derived fibroblasts to facilitate regeneration of the mineralized tissues of the periodontium...
  74. doi In vitro cartilage tissue engineering using cancellous bone matrix gelatin as a biodegradable scaffold
    Bo Yang
    College of Medicine, Xi an Jiaotong University, Yanta West Road, No 76, Yanta District, Xi an, Shaanxi Province 710061, People s Republic of China
    Biomed Mater 5:045003. 2010
    In this study, we constructed tissue-engineered cartilage using allogeneic cancellous bone matrix gelatin (BMG) as a scaffold. Allogeneic BMG was prepared by sequential defatting, demineralization and denaturation...
  75. ncbi In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1
    Eleftherios Tsiridis
    Academic Unit of Trauma and Orthopaedic Surgery, Clarendon Wing, Leeds General Infirmary, Leeds, UK
    Expert Opin Biol Ther 9:9-19. 2009
    Allografting is currently used in lower limb reconstruction surgery. Demineralised bone matrix (DBM) is more osteoinductive compared with allografts but lacks mechanical strength...
  76. doi Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis
    Mary H Schweitzer
    North Carolina State University, Raleigh, NC 27695, USA
    Science 324:626-31. 2009
    ..Microstructural and immunological data are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analyses of Brachylophosaurus collagen sequenced by mass spectrometry ..
  77. ncbi Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse
    T Ohtsuki
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Calcif Tissue Int 63:167-72. 1998
    ..lesions and the intervertebral disk lesions of the twy mouse, we assessed the mRNA expression of noncollagenous bone matrix proteins such as osteocalcin, osteonectin, osteopontin, and matrix Gla protein (MGP) by in situ hybridization, ..
  78. doi Demineralised bone matrix in veterinary orthopaedics: a review
    J F Innes
    Musculoskeletal Research Group and Small Animal Teaching Hospital, Department of Comparative Molecular Medicine, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Cheshire, CH64 7TE, England
    Vet Comp Orthop Traumatol 23:393-9. 2010
    Demineralised bone matrix (DBM) is commonly used in human orthopaedics as an allograft prepared from cortical bone...
  79. doi Crosslinked three-dimensional demineralized bone matrix for the adipose-derived stromal cell proliferation and differentiation
    Yannan Zhao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Tissue Eng Part A 15:13-21. 2009
    ..Demineralized bone matrix (DBM) has been used for tissue reconstruction because collagen presents good cell compatibility...
  80. ncbi BMP stimulation of alkaline phosphatase activity in pluripotent mouse C2C12 cells is inhibited by dermatopontin, one of the most abundant low molecular weight proteins in demineralized bone matrix
    Keyvan Behnam
    Department of Physiological Sciences, University of California, Los Angeles, CA, USA
    Connect Tissue Res 47:271-7. 2006
    Demineralized bone matrix (DBM) is a complex mixture of osteoinductive bone morphogenetic proteins (BMPs), as well as BMP-binding proteins that regulate BMP bioactivity and localization...
  81. ncbi The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2
    Hang Lin
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing, China
    Biomaterials 29:1189-97. 2008
    Demineralized bone matrix (DBM) is a collagen-based scaffold, but its low mechanical strength and limited BMP-2 binding ability restrict its application in bone repair...
  82. doi Autograft versus allograft with or without demineralized bone matrix in posterolateral lumbar fusion in rabbits. Laboratory investigation
    Julio Urrutia
    Department of Orthopaedic Surgery, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurosurg Spine 9:84-9. 2008
    ..Allograft has been used, but has been reported to result in lower fusion rates. Demineralized bone matrix (DBM) has also been used and reportedly increases the fusion rate in a variety of critical defect models...
  83. ncbi [The influence of mesenchymal stem cells on bone tissue regeneration upon implantation of demineralized bone matrix]
    P V Krugliakov
    Tsitologiia 47:466-77. 2005
    ..The implantation of rat's DBM with MSC led to the formation of a full value bone. MSC suppressed inflammation, when transplantation of hen's DBM was carried out. The application of MSC always improved bone tissue regeneration...
  84. ncbi Percutaneous reaming of simple bone cysts in children followed by injection of demineralized bone matrix and autologous bone marrow
    Anastasios D Kanellopoulos
    Department of Pediatric Orthopaedics, KAT Accident Hospital, Athens, Greece
    J Pediatr Orthop 25:671-5. 2005
    ..unicameral bone cysts using a combination of percutaneous reaming and injection of a mixture of demineralized bone matrix and autologous bone marrow. Follow-up ranged from 12 to 42 months (mean 28 months)...
  85. ncbi Assay of bone morphogenetic protein-2, -4, and -7 in human demineralized bone matrix
    William S Pietrzak
    Biomet, Inc, Warsaw, Indiana 46581, USA
    J Craniofac Surg 17:84-90. 2006
    Demineralized bone matrix (DBM) is a widely used bone graft material that derives its osteoinductive potential from matrix-associated bone morphogenetic proteins (BMPs)...
  86. ncbi Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice
    Don M Ranly
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive N W, Atlanta, GA 30332, USA
    J Bone Joint Surg Am 87:2052-64. 2005
    ..The purpose of this study was to examine the effect of PDGF on the ability of human demineralized bone matrix to induce bone formation in a nude-mouse muscle-implantation model...
  87. ncbi Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice
    Don M Ranly
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332 0363, USA
    J Bone Joint Surg Am 89:139-47. 2007
    ..whether platelet-rich plasma is a clinically effective adjunct to osteoinductive agents such as demineralized bone matrix. It contains platelet-derived growth factor (PDGF), which decreases osteoinduction by human demineralized bone ..
  88. ncbi Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis
    J Schedel
    Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, Regensburg, Germany
    Scand J Immunol 60:514-23. 2004
    ..takes place, we investigated the adherence of SF from patients with OA and RA to different cartilage and bone matrix proteins...
  89. ncbi Role of bovine bone morphogenetic proteins in bone matrix protein and osteoblast-related gene expression during rat bone marrow stromal cell differentiation
    ZhenMing Hu
    Orthobiologics Laboratory, Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    J Craniofac Surg 16:1006-14. 2005
    ..We examined alkaline phosphatase (ALP) by assay, immunohistochemical studies for bone matrix proteins, and mRNA expression of bone matrix proteins and osteoblast-related analysis by reverse-transcription ..
  90. ncbi GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 2: Clinical results
    Paul A Fugazzotto
    Int J Periodontics Restorative Dent 23:599-605. 2003
    ..Secured titanium-reinforced membranes were shown to be the most ideal means by which to ensure the final morphology of the regenerated hard tissues...
  91. ncbi Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs
    Sotirios Vastardis
    Periodontics Department, Louisiana State University School of Dentistry, New Orleans, LA 70119, USA
    J Periodontol 76:1690-6. 2005
    Peptide-enhanced (using the peptide 15 [P-15] synthetic peptide) anorganic bone matrix (ABM) particulate (PPart) grafts have demonstrated clinical and histologic success in human periodontal defects...
  92. ncbi Retroviral delivery of Noggin inhibits the formation of heterotopic ossification induced by BMP-4, demineralized bone matrix, and trauma in an animal model
    David Hannallah
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213 2582, USA
    J Bone Joint Surg Am 86:80-91. 2004
    ..The heterotopic ossification of muscles, tendons, and ligaments is a common problem faced by orthopaedic surgeons. We investigated the ability of Noggin (a BMP [bone morphogenetic protein] antagonist) to inhibit heterotopic ossification...
  93. ncbi Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix
    Barbara Blum
    Wright Medical Technology, Inc, Arlington, Tenn, USA
    Orthopedics 27:s161-5. 2004
    Osteoinductivity of demineralized bone matrix has been attributed to bone morphogenetic proteins (BMP)...
  94. ncbi Instrumented posterolateral lumbar fusion using coralline hydroxyapatite with or without demineralized bone matrix, as an adjunct to autologous bone
    J S Thalgott
    International Spinal Development and Research Foundation, 600 South Rancho Drive, Suite 101, Las Vegas, NV 89106, USA
    Spine J 1:131-7. 2001
    ..However, difficult-to-fuse patients, such as smokers, elderly patients with poor bone quality and/or quantity, or patients with prior posterior surgeries, may have somewhat lower fusion rates...
  95. ncbi MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21
    Mary Macdougall
    Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7888, San Antonio, TX 78229 3900, USA
    Connect Tissue Res 43:320-30. 2002
    ..Our data provide the first evidence that MEPE/OF45 is expressed during odontogenesis and should be considered as a candidate gene for dentin structural diseases mapping to human chromosome 4q21...
  96. doi Bone matrix quality and plasma homocysteine levels
    S Blouin
    4th Medical Department, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Hanusch Hospital, Austria
    Bone 44:959-64. 2009
    ..The results of the present study offer a mechanism by which homocysteine affects bone quality, but caution should be exercised since all patients examined had sustained fracture...
  97. ncbi Osteogenesis by guided tissue regeneration and demineralized bone matrix
    N Mardas
    Department of Periodontology and Oral Gerontology, Royal Dental College, University of Aarhus, Denmark
    J Clin Periodontol 30:176-83. 2003
    To evaluate in a discriminating capsule model whether bone formation by guided tissue regeneration (GTR) may be influenced by concomitant implantation of demineralized bone matrix (DBM).
  98. ncbi [Three-tunnels core decompression with implantation of bone marrow stromal cells (bMSCs) and decalcified bone matrix (DBM) for the treatment of early femoral head necrosis]
    Wei feng Ji
    Department of Orthopaedics and Traumatology, the Hospital of Zhejiang Province of TCM, Hangzhou 310006, Zhejiang, China
    Zhongguo Gu Shang 21:776-8. 2008
    ..3-tunnels core decompression with implantation of bone marrow stromal cells(bMSCs) and decalcified bone matrix (DBM) for treatment of femoral head necrosis in early stages, and to study its therapeutic results and ..
  99. ncbi Lumican is a major proteoglycan component of the bone matrix
    Afshin Raouf
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ont, Toronto, Canada
    Matrix Biol 21:361-7. 2002
    ..population of committed osteoprogenitors that in the presence of appropriate supplements form a mineralized bone matrix. The development of the MC3T3-E1 cells can be divided into three major stages, namely, proliferation, ..
  100. ncbi Repair of bone defect using bone marrow cells and demineralized bone matrix supplemented with polymeric materials
    Basan Gowda S Kurkalli
    Investigator in Charge, The international center for Cell Therapy and Cancer Immunotherapy, Top Ichilov at Weizman Center, Tel Aviv Medical Complex, 14 Weizman Street, Tel Aviv 64239, Israel
    Curr Stem Cell Res Ther 5:49-56. 2010
    We present a novel, reverse thermo-responsive (RTR) polymeric osteogenic composite comprising demineralized bone matrix (DBM) and unmanipulated bone marrow cells (BMC) for repair of bone defects...
  101. doi Transforming growth factor beta derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment
    Shinya Sato
    Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
    Cancer Sci 99:316-23. 2008
    ..tumors in the bone microenvironment stimulate bone resorption, resulting in release of growth factors from the bone matrix that play important roles in tumor growth and osteoclast induction...

Research Grants76

  1. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2010
    ..We also showed that maspin specifically binds to type I collagen, the most abundant protein in bone matrix. While maspin stabilized PC cell attachment to type I collagen, type I collagen further enhanced the maspin-..
  2. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2010
    ..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
  3. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..An osteoclast-specific cysteine proteinase, cathepsin K, plays a specialized role in the resorption of organic bone matrix. It was shown that cathepsin K inhibitors (CKI) are effective in reducing osteoclast-mediated bone resorption ..
  4. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..The hypotheses are that certain FGFs released from bone matrix (FGF2), the suture cells, and the dura mater (other that FGF2 or 7) diffuse to the extracellular matrix of the ..
  5. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..bone in large segmental bone defects using a load-bearing, biodegradable carrier carrying demineralized bone matrix (DBM)...
  6. MATRIX PROTEIN/INTEGRIN MEDIATED OSTEOCLAST REGULATION
    Keith Hruska; Fiscal Year: 1999
    ..The studies in this proposal analyze signal transduction which results from bone matrix proteins interacting with osteoclasts as they attach to bone surfaces...
  7. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    Sarah L Dallas; Fiscal Year: 2010
    ..We will for the first time dynamically image the assembly process by which key bone matrix proteins are deposited in living bone cells and determine how the motile properties of the cells contribute to ..
  8. BONE MATRIX AND BONE RESORPTION
    PAUL ODGREN; Fiscal Year: 2006
    These studies, all derived from our previous work exploring the interactions of bone matrix and bone resorption, focus on genes and other factors impacting skeletal development and resorption...
  9. BONE MATRIX AND BONE RESORPTION
    PAUL ODGREN; Fiscal Year: 2009
    ..It is a competitive revision request for grant RO1 DE 007444, "Bone matrix and bone resorption," under which we are investigating the osteoclast cell biology of a protein we discovered ..
  10. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2010
    Fluoride in various chemical forms and exposures has been repeatedly shown to have actions on bone matrix and on bone cells (osteoblasts and osteoclasts)...
  11. Genetic Determinants of Physiological Responses to Fluoride in Bone
    ERIC EVERETT; Fiscal Year: 2009
    Fluoride in various chemical forms and exposures has been repeatedly shown to have actions on bone matrix and on bone cells (osteoblasts and osteoclasts)...
  12. Genetic Determinants of Physiological Responses to Fluoride in Bone
    ERIC EVERETT; Fiscal Year: 2009
    Fluoride in various chemical forms and exposures has been repeatedly shown to have actions on bone matrix and on bone cells (osteoblasts and osteoclasts)...
  13. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva P Kotha; Fiscal Year: 2010
    ..Osteocytes, cells embedded in the bone matrix, are thought to be responsible for sensing and coordinating adaptive responses in the skeleton...
  14. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva Kotha; Fiscal Year: 2009
    ..Osteocytes, cells embedded in the bone matrix, are thought to be responsible for sensing and coordinating adaptive responses in the skeleton...
  15. Mechanotransduction in Osteocytic Network and Osteoblast
    X Guo; Fiscal Year: 2007
    ..Osteocytes are intrinsically three-dimensional (3D) bone cells that are encased in mineralized extracellular bone matrix and interconnected with each other as well as osteoblasts through numerous intercellular processes by gap ..
  16. The Mechanism of Coupling Bone Resorption and Formation
    Xu Cao; Fiscal Year: 2007
    ..bone is accomplished by precise coordination between two cell types: osteoblasts, which deposit the calcified bone matrix; and osteoclasts, which resorb bone...
  17. Mechanobiology of 3D Trabecular Bone Explants
    X Guo; Fiscal Year: 2009
    ..OCY) are intrinsically three-dimensional (3D), mature bone cells encased in 3D mineralized extracellular bone matrix. Recent studies indicate the critical roles of osteocytes in detecting mechanical signals and maintaining ..
  18. Mechanobiology of 3D Trabecular Bone Explants
    X Edward Guo; Fiscal Year: 2010
    ..OCY) are intrinsically three-dimensional (3D), mature bone cells encased in 3D mineralized extracellular bone matrix. Recent studies indicate the critical roles of osteocytes in detecting mechanical signals and maintaining ..
  19. Breast Cancer Osteolysis--Regulation of PTHrP by TGFBeta
    Theresa Guise; Fiscal Year: 2005
    ..Transforming growth factor (TGF) beta, abundant in bone matrix and released as a consequence of osteoclastic bone resorption, stimulates PTHrP production by cancer cells...
  20. Genetic Control of Osteoblast Differentiation
    Benoit de Crombrugghe; Fiscal Year: 2010
    ..precursor cells to become fully functioning osteoblasts, which synthesize and secrete the components of the bone matrix. Based on our preliminary results, we hypothesize that Osx continues to have a critical role in osteoblast and ..
  21. HOMOCYSTEINE MODIFIES BONE MATRIX AND MINERALIZATION
    CHARLES PRINCE; Fiscal Year: 2007
    ..modification, we will also experiment investigate conditions that result in the incorporation of Hcy into bone matrix proteins...
  22. BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATION
    JEFFREY GORSKI; Fiscal Year: 2003
    ..into supramolecular microfibrillar complexes, serves as a structural framework defining the volume of primary bone matrix to be subsequently calcified...
  23. REGULATION OF OSTEOBLAST GENE EXPRESSION BY CYTOKINES
    John Harrison; Fiscal Year: 1999
    ..Type I collagen is the major structural component of bone matrix. The following specific aims are proposed: l)To examine the basal expression and regulation of NF-IL6, NF-kB ..