bone matrix

Summary

Top Publications

  1. ncbi Matrix vesicles and calcification
    H Clarke Anderson
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 2017 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
    Curr Rheumatol Rep 5:222-6. 2003
  2. ncbi Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix
    Bo Han
    Tissue Engineering Laboratory, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Orthop Res 21:648-54. 2003
  3. ncbi Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    Masato Igarashi
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Mol Histol 35:3-10. 2004
  4. pmc Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone
    M Wendel
    Department of Cell and Molecular Biology, University of Lund, S 221 00 Lund, Sweden
    J Cell Biol 141:839-47. 1998
  5. ncbi Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide
    Bing Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    J Biomed Mater Res A 80:428-34. 2007
  6. pmc Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up
    Kivanc Topuz
    GATA Haydarpasa Egitim Hastanesi, Norosirurji Servisi, 34668 Istanbul, Turkey
    Eur Spine J 18:238-43. 2009
  7. ncbi Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase
    W Tesch
    Ludwig Boltzmann Institute of Osteology 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    J Bone Miner Res 18:117-25. 2003
  8. ncbi Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects
    Sara A Bender
    Private Practice, Frisco, TX, USA
    J Periodontol 76:768-77. 2005
  9. ncbi Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells
    Cyril Thouverey
    Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    J Proteomics 74:1123-34. 2011
  10. pmc Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst
    Claudia Di Bella
    Department of Oncology Orthopaedic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Orthop Relat Res 468:3047-55. 2010

Detail Information

Publications321 found, 100 shown here

  1. ncbi Matrix vesicles and calcification
    H Clarke Anderson
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 2017 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
    Curr Rheumatol Rep 5:222-6. 2003
    ..In diseases such as osteoarthritis, crystal deposition arthritis, and atherosclerosis, MVs initiate pathologic calcification, which, in turn, augments disease progression...
  2. ncbi Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix
    Bo Han
    Tissue Engineering Laboratory, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Orthop Res 21:648-54. 2003
    A sensitive, rapid, reliable and quantitative method to check the bone forming potential of demineralized bone matrix (DBM) has been developed...
  3. ncbi Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts
    Masato Igarashi
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    J Mol Histol 35:3-10. 2004
    ..Thus, it is likely that Dex may promote osteoblastic differentiation and mineralization of FRCC by inducing the expression of Cbfa1 and Osx genes in vitro...
  4. pmc Bone matrix proteins: isolation and characterization of a novel cell-binding keratan sulfate proteoglycan (osteoadherin) from bovine bone
    M Wendel
    Department of Cell and Molecular Biology, University of Lund, S 221 00 Lund, Sweden
    J Cell Biol 141:839-47. 1998
    ..The binding appears to be mediated by the integrin alphavbeta3, since this was the only integrin isolated by osteoadherin affinity chromatography of surface-iodinated osteoblast extracts...
  5. ncbi Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide
    Bing Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China
    J Biomed Mater Res A 80:428-34. 2007
    ..Bone filling materials are important in bone tissue restoration. In this study, the demineralized bone matrix (DBM) was activated with the engineering human bone morphogenetic protein-2 (BMP-2)...
  6. pmc Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up
    Kivanc Topuz
    GATA Haydarpasa Egitim Hastanesi, Norosirurji Servisi, 34668 Istanbul, Turkey
    Eur Spine J 18:238-43. 2009
    ..To achieve fusion PEEK cages packed with demineralized bone matrix mixed with autologous blood were used...
  7. ncbi Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase
    W Tesch
    Ludwig Boltzmann Institute of Osteology 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    J Bone Miner Res 18:117-25. 2003
    ..Also, immunolabeling of osteopontin (OPN) revealed an abnormal distribution pattern of the protein within the bone matrix. Whereas in the wild-type animals OPN was predominantly observed in cement and reversal lines, in the null ..
  8. ncbi Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects
    Sara A Bender
    Private Practice, Frisco, TX, USA
    J Periodontol 76:768-77. 2005
    Demineralized bone matrix (DBX) paste and putty are particulate demineralized bone matrices in a 2% or 4% hyaluronate carrier, respectively...
  9. ncbi Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells
    Cyril Thouverey
    Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St, 02 093 Warsaw, Poland
    J Proteomics 74:1123-34. 2011
    ....
  10. pmc Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst
    Claudia Di Bella
    Department of Oncology Orthopaedic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Orthop Relat Res 468:3047-55. 2010
    ..Various treatments have been proposed but there is no consensus regarding the best procedure...
  11. ncbi Enhanced guided bone regeneration with a resorbable chamber containing demineralized bone matrix
    Roberto Giardino
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, University of Bologna, Bologna, Italy
    J Trauma 52:933-7. 2002
    ..The injection of bone marrow stem cells into the chamber had proven to enhance bone regeneration...
  12. ncbi Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function
    Anke Bentmann
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    J Bone Miner Res 25:706-15. 2010
    The bone matrix is composed mostly of collagen, but the initial and continuous presence of fibronectin was found to be crucial for collagen matrix integrity in vitro...
  13. ncbi Bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro
    Elerin Kärner
    Center for Oral Biology, Institute of Odontology, Karolinska Institutet, SE 141 04 Stockholm, Sweden
    Stem Cells Dev 16:39-52. 2007
    b>Bone matrix production and mineralization involves sophisticated mechanisms, including the initial formation of an organic extracellular matrix into which inorganic hydroxyapatite crystals are later deposited...
  14. pmc Fourier transform infrared imaging microspectroscopy and tissue-level mechanical testing reveal intraspecies variation in mouse bone mineral and matrix composition
    Hayden William Courtland
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Calcif Tissue Int 83:342-53. 2008
    ..are therefore able to differentially modulate the composition of their bone mineral and the maturity of their bone matrix in conjunction with tissue-level mechanical properties...
  15. ncbi Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition
    D Miao
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3A 1A1
    Endocrinology 142:926-39. 2001
    ..contributes to the pathogenesis of osteomalacia, we examined the abnormalities of mineralization, Phex, and bone matrix protein expression occurring in Hyp mice in vivo and in ex vivo bone marrow cell cultures...
  16. ncbi Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
    ..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
  17. ncbi Staphylococcus aureus adhesion to bone matrix and bone-associated biomaterials
    M C Hudson
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    FEMS Microbiol Lett 173:279-84. 1999
    ..The bacterium expresses several adhesins that facilitate bacterial binding to the bone matrix and to bone implant biomaterials coated with host plasma constituents. The relevant S...
  18. pmc A comparison of commercially available demineralized bone matrix for spinal fusion
    Jeffrey C Wang
    Department of Orthopaedics and Traumatology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Eur Spine J 16:1233-40. 2007
    ..the available grafting material as well as to increase spinal fusion rates, the utilization of a demineralized bone matrix (DBM) as a graft extender or replacement is common...
  19. ncbi Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity
    Y Takeuchi
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan
    J Biol Chem 269:32634-8. 1994
    ..of distribution and actions of transforming growth factor (TGF)-beta in bone, TGF-beta 1 binding to extracted bone matrix proteins and the influence of such binding on TGF-beta 1 actions were examined...
  20. ncbi Donor age and gender effects on osteoinductivity of demineralized bone matrix
    Kathy Traianedes
    Osteotech, Inc, 51 James Way, Eatontown, New Jersey 07724, USA
    J Biomed Mater Res B Appl Biomater 70:21-9. 2004
    Allogeneic demineralized bone matrix (DBM) has been used extensively as a clinical graft material because of its inherent osteoinductive and osteoconductive properties...
  21. ncbi Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2
    Bing Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100080, China
    Biomaterials 28:1027-35. 2007
    ..When demineralized bone matrix (DBM) impregnated with BMP2-h was implanted subcutaneously in rats, homogeneous bone formation was observed...
  22. pmc Attachment of osteocyte cell processes to the bone matrix
    L M McNamara
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY, USA
    Anat Rec (Hoboken) 292:355-63. 2009
    ..To date the nature of this attachment is not understood. Osteocytes are embedded in mineralized bone matrix, but maintain a pericellular space (50-80 nm) to facilitate fluid flow and transport of metabolites...
  23. ncbi Demineralized bone matrix and spinal arthrodesis
    Kenneth J H Lee
    Department of Orthopaedic Surgery, University of California at Los Angeles, School of Medicine, 1250 16th Street, 7th Floor, Tower 745, Santa Monica, CA 90404, USA
    Spine J 5:217S-223S. 2005
    ..One such alternative is demineralized bone matrix (DBM)...
  24. ncbi The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity
    Bo Han
    Department of Surgery, University of Southern California, 1840 North Soto Street EDM 191, Los Angeles, CA 90032, USA
    J Bone Joint Surg Am 91:1459-70. 2009
    Demineralized bone matrix is an osteoinductive and osteoconductive material that is often used in orthopaedic surgery to induce bone formation...
  25. ncbi Comparative evaluation of the osteoinductivity of two formulations of human demineralized bone matrix
    Satoshi Takikawa
    Department of Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biomed Mater Res A 65:37-42. 2003
    In the United States, demineralized bone matrix (DBM) is considered a transplantable tissue and therefore is regulated primarily by the American Association of Tissue Banks...
  26. ncbi Clinical and radiographic treatment evaluation of class III furcation defects using GTR with and without inorganic bone matrix
    Daniela Bazan Palioto
    University of Sao Paulo, School of Dentistry of Ribeirao Preto, Brazil
    J Clin Periodontol 30:1-8. 2003
    The aim of this study was to evaluate the effect of guided tissue regeneration (GTR) alone and in conjunction with a bovine inorganic bone matrix in furcation defects.
  27. ncbi Development and characterization of an acellular porcine cartilage bone matrix for use in tissue engineering
    Ehab Kheir
    Institude of Medical and Biological Engineering, The University of Leeds, Leeds, UK
    J Biomed Mater Res A 99:283-94. 2011
    ..In conclusion, this study has generated data on the production of an acellular cartilage bone matrix scaffold for use in osteochondral defect repair...
  28. ncbi Optimizing human demineralized bone matrix for clinical application
    E Maddox
    Department of Tissue Biology, Holland Laboratory, American Red Cross, Rockville, Maryland, USA
    Tissue Eng 6:441-8. 2000
    The use of human demineralized bone matrix (DBM) powder in periodontal and orthopedic applications is limited by the variability in the osteoinductive or osteoconductive properties of the material...
  29. ncbi The effect of demineralized intramembranous bone matrix and basic fibroblast growth factor on the healing of allogeneic intramembranous bone grafts in the rabbit
    Mei Lu
    Hard Tissue Laboratory, Faculty of Dentistry, University of Hong Kong, 34 Hospital Road, Hong Kong, Hong Kong
    Arch Oral Biol 47:831-41. 2002
    ..IM) bone, fresh-frozen allogeneic IM bone only, fresh-frozen allogeneic IM bone and demineralized bone matrix powder prepared from intramembranous bone (DBM(IM)) only, and fresh-frozen allogeneic IM bone and basic ..
  30. ncbi Use of a calcium sulfate-based bone graft substitute for benign bone lesions
    S Gitelis
    Department of Orthopedic Surgery, Rush Medical College, Chicago, Ill 60612, USA
    Orthopedics 24:162-6. 2001
    Twenty-three patients with a benign bone lesion grafted with calcium sulfate, with and without demineralized bone matrix, were reviewed...
  31. ncbi Dose-dependent toxicity of a commercially available demineralized bone matrix material
    J C Wang
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, School of Medicine 90095 6902, USA
    Spine (Phila Pa 1976) 26:1429-35; discussion 1435-6. 2001
    A relative risk assessment was performed to determine the safety of three commercially available Grafton demineralized bone matrix quantities used in athymic rats.
  32. ncbi Injectable CMC/PEI gel as an in vivo scaffold for demineralized bone matrix
    Kyung Sook Kim
    Fusion Biotechnology Research Center, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Korea
    Biomed Mater Eng 19:381-90. 2009
    ..carboxymethylcellulose (CMC) and poly(ethyleneimine) (PEI) for use as an in vivo carrier of demineralized bone matrix (DBM)...
  33. ncbi Effects of collagen unwinding and cleavage on the mechanical integrity of the collagen network in bone
    X Wang
    Mechanical Engineering and Biomechanics, The University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, Texas 78249, USA
    Calcif Tissue Int 71:186-92. 2002
    ....
  34. ncbi Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice
    Hironobu Suzuki
    Division of Anatomy and Cell Biology of the Hard Tissue, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Arch Histol Cytol 68:371-81. 2005
    ..The present study examined the histological and ultrastructural features of osteocytes and the surrounding bone matrix in klotho-deficient mice...
  35. ncbi Quantification of various growth factors in different demineralized bone matrix preparations
    B Wildemann
    Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Campus Virchow, Germany
    J Biomed Mater Res A 81:437-42. 2007
    Besides autografts, allografts, and synthetic materials, demineralized bone matrix (DBM) is used for bone defect filling and treatment of non-unions. Different DBM formulations are introduced in clinic since years...
  36. pmc The effect of adding an equine bone matrix protein lyophilisate on fixation and osseointegration of HA-coated Ti implants
    Jorgen Baas
    Orthopedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Build 1a, 8000 Aarhus C, Denmark
    J Biomed Mater Res A 100:188-94. 2012
    ..the fixation of orthopedic implants could be improved by adding an osteoinductive extract of lyophilized equine bone matrix proteins (Colloss E, Ossacur AG, Germany), between the implant and the surrounding bone...
  37. ncbi Allograft bone matrix versus synthetic bone graft substitutes
    Gerald Zimmermann
    Theresienkrankenhaus Mannheim, Department of Trauma and Orthopaedic Surgery, University of Heidelberg, Germany
    Injury 42:S16-21. 2011
    ..Alternatives have included allografts and in recent years also demineralized bone matrix. The growing availability of good synthetic bone grafts and their advantages in safety and avoiding donor-site ..
  38. ncbi Mechanical stretch induced calcium efflux from bone matrix stimulates osteoblasts
    Xuanhao Sun
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Bone 50:581-91. 2012
    ..924±0.742 pmol cm(-2)s(-1)) from regions of devitalized bone matrix undergoing post-yield strains, induced by a stress concentrator...
  39. ncbi Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone
    Xu Ming Dai
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Bone Miner Res 19:1441-51. 2004
    ..We therefore examined the micro- and ultrastructure of the developing bones of osteoclast-deficient CSF-1R-nullizygous mice (Csf1r(-/-) mice)...
  40. ncbi PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation
    Michael Thorwarth
    Department of Oral and Maxillofacial Surgery Plastic Surgery, University of Jena, Erlanger Allee 101, D 07747 Jena, Germany
    Bone 38:30-40. 2006
    ..formation after filling defined defects of the frontal skull with autogenous bone or a deproteinized bovine bone matrix (DBBM) in combination with platelet-rich plasma (PRP)...
  41. pmc FIAT represses bone matrix mineralization by interacting with ATF4 through its second leucine zipper
    Vionnie W C Yu
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    J Cell Biochem 105:859-65. 2008
    ..This structure-function analysis reveals that FIAT interacts with ATF4 and modulates its activity through its second leucine zipper motif...
  42. ncbi The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model
    Yu Po Lee
    Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA 90095 7036, USA
    J Spinal Disord Tech 18:439-44. 2005
    ..Currently, there are a number of different commercially available demineralized bone matrix (DBM) products available that have been prepared by different methods and have different carriers...
  43. ncbi The enhanced modulation of key bone matrix components by modified Titanium implant surfaces
    M R Khan
    Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London WC1X 8LD, UK
    Bone 50:1-8. 2012
    ..05). These findings suggest that modified Ti surfaces induce an enhancement in osteogenic commitment and differentiation, which likely underlie the deposition of more stable bone matrix early in the healing process in vivo.
  44. ncbi Histologic analysis of implant sites after grafting with demineralized bone matrix putty and sheets
    D P Callan
    Osteotech, Inc, 51 James Way, Eatontown, NJ 07724, USA
    Implant Dent 9:36-44. 2000
    ..Conflicting reports concerning the osteoinductivity of demineralized bone matrix (DBM) and historical use of synthetic bone graft substitutes has limited the use of DBM in oral and ..
  45. ncbi Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone
    Dario Fortunati
    Department of Biochemistry, Institute of Basic Medical Sciences, PO Box 1112 Blindern, University of Oslo, N 0317 Oslo, Norway
    Matrix Biol 29:594-601. 2010
    ..In conclusion, the present study provides novel observations related to the expression, distribution and regulation of periostin in bone cells and extracellular matrix...
  46. ncbi The effect of demineralized bone matrix-calcium sulfate with vancomycin on calcaneal fracture healing and infection rates: a prospective study
    Christopher Bibbo
    Department of Orthopaedic Surgery, Marshfield Clinic, 1000 North Oak Avenue, WI 54449, USA
    Foot Ankle Int 27:487-93. 2006
    ..We hypothesized that human demineralized bone matrix (DBM) calcium sulfate (CaSO(4)) might act as a reasonable alternative to autograft in calcaneal fractures...
  47. ncbi GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 1: histologic results
    Paul A Fugazzotto
    Int J Periodontics Restorative Dent 23:361-9. 2003
    ..13% of the core biopsy volume. Bone regeneration was evident in all specimens...
  48. pmc Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment
    Rachel F Cox
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e41679. 2012
    ..The expression of several bone matrix proteins were monitored throughout the process of mineralization and increased expression of collagen type 1 ..
  49. ncbi Restoration of bone defect and enhancement of bone ingrowth using partially demineralized bone matrix and marrow stromal cells
    Hsin Nung Shih
    Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chang Gung University, No 5, Fu Hsing Street, Kwei Shan, Tao Yuan 333, Taiwan
    J Orthop Res 23:1293-9. 2005
    This study aimed to investigate the capability of combining marrow stromal cells (MSC) and partially demineralized bone matrix (PDBM) to fill bone defect and enhance bone ingrowth using a canine non-weight-bearing gap model.
  50. ncbi Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix
    Yanchun Liu
    Department of Medicinal Chemistry and Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way Suite 205, Salt Lake City, Utah, 84108, USA
    J Orthop Res 24:1454-62. 2006
    ..of Carbylan-GSX, a crosslinked synthetic extracellular matrix (ECM), were used to deliver human demineralized bone matrix (DBM) in a rat femoral defect model...
  51. ncbi Safety and efficacy of commercially available demineralised bone matrix preparations: a critical review of clinical studies
    Georgios I Drosos
    Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece
    Injury 38:S13-21. 2007
    Demineralised bone matrix (DBM), a form of allograft, possesses the properties of osteoinductivity and osteoconductivity...
  52. ncbi Safety and efficacy of use of demineralised bone matrix in orthopaedic and trauma surgery
    Haralampos T H Dinopoulos
    University of Leeds, Academic Department of Trauma and Orthopaedics, School of Medicine, St James s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UK
    Expert Opin Drug Saf 5:847-66. 2006
    Demineralised bone matrix (DBM) acts as an osteoconductive, and possibly as an osteoinductive, material. It is widely used in orthopaedic, neurosurgical, plastic and dental areas...
  53. pmc Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo
    Thomas Meury
    Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, Canada
    Mol Cell Biol 30:43-53. 2010
    ..The reduced quantity of bone matrix in S43A mutant bones was mineralized faster, as demonstrated by the significantly reduced mineralization lag ..
  54. ncbi Vascular endothelial growth pattern during demineralized bone matrix induced osteogenesis
    A B Rabie
    Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong
    Connect Tissue Res 36:337-45. 1997
    ..of the current study was to determine the timely ingrowth of blood vessels associated with demineralized bone matrix (DMB) induced osteogenesis...
  55. ncbi Core decompression combined with implantation of a demineralised bone matrix for non-traumatic osteonecrosis of the femoral head
    L Helbig
    Department für Orthopädie, Unfallchirurgie und Paraplegiologie, Universitätsklinik Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany
    Arch Orthop Trauma Surg 132:1095-103. 2012
    ..This study evaluated patients after core decompression combined with an augmentation by a demineralised bone matrix, and particularly aimed to report long-term conversion rates to total hip replacement (THR).
  56. pmc Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells
    Shingo Maeda
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo
    EMBO J 23:552-63. 2004
    Transforming growth factor-beta (TGF-beta), one of the most abundant cytokines in bone matrix, has positive and negative effects on bone formation, although the molecular mechanisms of these effects are not fully understood...
  57. ncbi Feasibility of demineralized bone matrix for craniomaxillofacial contour restoration
    Tolga Eryilmaz
    Department of Plastic, Reconstructive and Aesthetic Surgery, Gazi University Faculty of Medicine, Ankara, Turkey
    J Craniofac Surg 22:1888-92. 2011
    Demineralized bone matrix (DBM) could be a good alternative for craniomaxillofacial contour restoration, especially in perialar, malar, temporal, and frontal regions...
  58. ncbi Use of demineralized bone matrix in ankle/hindfoot fusion
    David B Thordarson
    Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angles, CA 90033, USA
    Foot Ankle Int 24:557-60. 2003
    Sixty-three patients who underwent complex ankle or hindfoot fusion had demineralized bone matrix placed in their fusion site to stimulate fusion...
  59. ncbi Commercially available demineralized bone matrix compositions to regenerate calvarial critical-sized bone defects
    Tahsin Oguz Acarturk
    Division of Plastic and Reconstructive Surgery, University of Pittsburgh, PA, USA
    Plast Reconstr Surg 118:862-73. 2006
    Demineralized bone matrix products are often used by surgeons to regenerate bone. Several different types of carriers have been combined with demineralized bone matrix to improve clinical handling and surgical outcome...
  60. ncbi DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center for Environment and Health, 85764 Munich Neuherberg, Germany
    Nat Genet 38:1248-50. 2006
    ..4q21 and identified homozygous mutations in DMP1 (dentin matrix protein 1), which encodes a non-collagenous bone matrix protein expressed in osteoblasts and osteocytes...
  61. ncbi A cyclo peptide activates signaling events and promotes growth and the production of the bone matrix
    S Pallu
    INSERM U 577, Université Bordeaux Victor Segalen, Bordeaux 2, 33076 Bordeaux Cedex, France
    Peptides 24:1349-57. 2003
    ....
  62. ncbi Demineralized bone matrix in bone repair: history and use
    ELLIOTT GRUSKIN
    Synthes USA, 1302 Wrights Lane East, West Chester, PA 19380, USA
    Adv Drug Deliv Rev 64:1063-77. 2012
    Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms...
  63. ncbi [Inhibitory effect of bone sialoprotein silencing on the adhesion ability of breast cancer cells to bone matrix]
    Li Wang
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China
    Sheng Wu Gong Cheng Xue Bao 27:233-9. 2011
    ..research mainly to explore the effect of bone sialoprotein (BSP) silence by siRNA on the adhesion ability to bone matrix of bone-seeking breast cancer cells (MDA-MB-231BO)...
  64. ncbi Efficacy of composite allograft and demineralized bone matrix graft in treating tibial plateau fractures with bone loss
    Justin T Newman
    Department of Orthopedic Surgery, Denver Health Medical Center, University of Colorado School of Medicine, 777 Bannock St, Denver, CO 80204, USA
    Orthopedics 31:649. 2008
    ..We hypothesized a standardized protocol of internal fixation augmented with a mixture of demineralized bone matrix and corticocancellous allograft chips would result in high healing rates with minimal subsidence...
  65. ncbi Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice
    Ryszard Galus
    Chair and Department of Histology and Embryology, Center for Biostructure Research, Medical University in Warsaw, Chałubińskiego 5, PL 02 004 Warsaw, Poland
    Pharmacol Rep 58:443-7. 2006
    ..HO was induced by implantation of rat-derived demineralized bone matrix (DBM) into intramuscular pockets in CFW mice. Mice in the experimental groups received fluvastatin at 3...
  66. pmc Bone matrix osteonectin limits prostate cancer cell growth and survival
    Kristina Kapinas
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
    Matrix Biol 31:299-307. 2012
    ..To determine how bone matrix osteonectin affects the behavior of prostate cancer cells, we modeled prostate cancer cell-bone interactions ..
  67. ncbi Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization
    Lei Chen
    Biotechnology Research Center Hubei Province Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002, PR China
    Biomacromolecules 10:3193-8. 2009
    In previous studies, we have described the use of demineralized bone matrix (DBM) as a carrier for the localized delivery system of growth factors in vitro and in vivo...
  68. pmc Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone
    Elizabeth Miller
    Musculoskeletal Integrity Program, Research Division, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA
    Calcif Tissue Int 81:206-14. 2007
    ..To investigate the bone matrix properties, tensile tests combined with geometric analyses were conducted on demineralized femora...
  69. pmc In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption
    X Neil Dong
    Department of Health and Kinesiology, The University of Texas at Tyler, Tyler, TX 75799, USA
    Bone 49:174-83. 2011
    ..and elderly (76±4years old) groups were examined to determine the spatial-temporal distribution of AGEs in bone matrix and its effect on bone resorption activities by directly culturing osteoclastic cells on bone slices...
  70. ncbi Acidic bone matrix proteins and their roles in calcification
    Ryuichi Fujisawa
    Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Hokkaido University, N13W7, Sapporo, Japan 080 8586
    Front Biosci (Landmark Ed) 17:1891-903. 2012
    ..Some of these acidic matrix proteins are immobilized on the collagen fibrils and induce nucleation of hydroxyapatite crystals. They can also modulate crystal shape by adsorption on a specific face of the crystals...
  71. ncbi Low oxygen tension enhances chondroinduction by demineralized bone matrix in human dermal fibroblasts in vitro
    Shuichi Mizuno
    Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Cells Tissues Organs 180:151-8. 2005
    ..In sum, hypoxia enhanced cartilage matrix accumulation by hDFs cultured with DBP. These defined conditions can optimize the use of dermal fibroblasts for cartilage tissue engineering...
  72. ncbi Autologous bone marrow grafting combined with demineralized bone matrix improves consolidation of docking site after distraction osteogenesis
    Ippokratis Hatzokos
    1st Orthopaedic Department of Aristotle University of the Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Bone Joint Surg Am 93:671-8. 2011
    ..We further sought to clarify whether the application of autologous bone marrow cells combined with demineralized bone matrix would substantially improve docking site consolidation.
  73. ncbi Anisotropy of demineralized bone matrix under compressive load
    Hanna Trebacz
    Department of Biophysics, Medical University of Lublin
    Acta Bioeng Biomech 13:71-6. 2011
    ..Both secant modulus of elasticity and AE parameters were significantly higher in T direction than in L direction, which is attributed to shifting and separation of lamellae of collagen fibrils and lamellae in bone matrix.
  74. ncbi Effects of fixation and decalcification on the immunohistochemical localization of bone matrix proteins in fresh-frozen bone sections
    Akihiro Hosoya
    Department of Oral Histology, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri, Nagano, 399 0781, Japan
    Histochem Cell Biol 123:639-46. 2005
    To examine the stability of bone matrix proteins for crystal dislocation, the immunolocalization of type I collagen, bone sialoprotein, and osteopontin was investigated during different stages of fixation and decalcification...
  75. ncbi The ratio of osteocytic incorporation to bone matrix formation in femoral neck cancellous bone: an enhanced osteoblast work rate in the vicinity of hip osteoarthritis
    G R Jordan
    Bone Research Group MRC, Department of Medicine, University of Cambridge Clinical School, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Calcif Tissue Int 72:190-6. 2003
    ..One possible approach to strengthening bone in osteoporosis might be to enhance the effective lifespan of the osteoblast by modulating TGFb-related pathway activity in its local environment...
  76. pmc Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells
    Jian Zhang
    Arkansas Children s Nutrition Center, Slot 512 20B 15 Children s Way, Little Rock, AR 72202, USA
    Age (Dordr) 35:807-20. 2013
    Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation...
  77. ncbi Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells
    Ethel H Alcantara
    Department of Food Science and Nutrition, Andong National University, Andong, KyungBook, South Korea
    J Nutr Biochem 22:1055-63. 2011
    ..The medium and cellular levels of Type 1 collagen and alkaline phosphatase (ALP), both of which are major bone matrix proteins, increased within the low range of diosgenin concentration (>0-3 μM), and this pattern was further ..
  78. ncbi Osteoinductivity of demineralized bone matrix in immunocompromised mice and rats is decreased by ovariectomy and restored by estrogen replacement
    J McMillan
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332, USA
    Bone 40:111-21. 2007
    The osteoinduction potential of human demineralized bone matrix (DBM) in females with low estrogen (E2) is unknown...
  79. ncbi The expression of bone matrix protein mRNAs around beta-TCP particles implanted into bone
    K Ohsawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res 52:460-6. 2000
    ..The latter cells may be macrophages and reflect foreign body reactions. Expression of these OPN mRNAs induced by implantation of beta-TCP may play a role in bone formation on the materials and in determining their biocompatibility...
  80. ncbi Intrinsic axial vascularization of an osteoconductive bone matrix by means of an arteriovenous vascular bundle
    Elias Polykandriotis
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Germany
    Plast Reconstr Surg 120:855-68. 2007
    ..The authors also evaluated corrosion cast and intravital magnetic resonance angiography as methods for monitoring and quantifying the angiogenic response...
  81. ncbi Early expression of bone matrix proteins in osteogenic cell cultures
    Paulo Tambasco de Oliveira
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dentistry, Universite de Montreal, QC, Canada
    J Histochem Cytochem 51:633-41. 2003
    ..These results indicate that an important proportion of cells used for plating contain BSP and OPN, a situation that should be taken into consideration in experimental analyses of osteoblast activity in vitro...
  82. ncbi Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts
    Beatrice Tonnarelli
    Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res A 89:687-96. 2009
    ..cartilaginous (hyaluronan-based scaffold), and plastic substrate culture on human osteoblast proliferation, bone matrix molecule, and inflammatory factor expression...
  83. ncbi Autograft versus allograft with or without demineralized bone matrix in posterolateral lumbar fusion in rabbits. Laboratory investigation
    Julio Urrutia
    Department of Orthopaedic Surgery, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurosurg Spine 9:84-9. 2008
    ..Allograft has been used, but has been reported to result in lower fusion rates. Demineralized bone matrix (DBM) has also been used and reportedly increases the fusion rate in a variety of critical defect models...
  84. ncbi Crosslinked three-dimensional demineralized bone matrix for the adipose-derived stromal cell proliferation and differentiation
    Yannan Zhao
    Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Tissue Eng Part A 15:13-21. 2009
    ..Demineralized bone matrix (DBM) has been used for tissue reconstruction because collagen presents good cell compatibility...
  85. ncbi BMP stimulation of alkaline phosphatase activity in pluripotent mouse C2C12 cells is inhibited by dermatopontin, one of the most abundant low molecular weight proteins in demineralized bone matrix
    Keyvan Behnam
    Department of Physiological Sciences, University of California, Los Angeles, CA, USA
    Connect Tissue Res 47:271-7. 2006
    Demineralized bone matrix (DBM) is a complex mixture of osteoinductive bone morphogenetic proteins (BMPs), as well as BMP-binding proteins that regulate BMP bioactivity and localization...
  86. ncbi The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2
    Hang Lin
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing, China
    Biomaterials 29:1189-97. 2008
    Demineralized bone matrix (DBM) is a collagen-based scaffold, but its low mechanical strength and limited BMP-2 binding ability restrict its application in bone repair...
  87. ncbi Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis
    Mary H Schweitzer
    North Carolina State University, Raleigh, NC 27695, USA
    Science 324:626-31. 2009
    ..Microstructural and immunological data are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analyses of Brachylophosaurus collagen sequenced by mass spectrometry ..
  88. ncbi In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1
    Eleftherios Tsiridis
    Academic Unit of Trauma and Orthopaedic Surgery, Clarendon Wing, Leeds General Infirmary, Leeds, UK
    Expert Opin Biol Ther 9:9-19. 2009
    Allografting is currently used in lower limb reconstruction surgery. Demineralised bone matrix (DBM) is more osteoinductive compared with allografts but lacks mechanical strength...
  89. ncbi Osseous healing using injectable calcium sulfate-based putty for the delivery of demineralized bone matrix and cancellous bone chips
    Thomas M Turner
    Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, Ill, USA
    Orthopedics 26:s571-5. 2003
    Three formulations of injectable calcium sulfate-based putties containing demineralized bone matrix (DBM), 50% DBM/50% cancellous bone (CB) chips, and 30% DBM/70% CB were studied in canines...
  90. ncbi Expression of bone matrix protein mRNAs by primary and cloned cultures of the regenerative phenotype of human periodontal fibroblasts
    S Ivanovski
    Department of Dentistry, University of Queensland, Brisbane, Australia
    J Dent Res 80:1665-71. 2001
    ..This study has identified markers that correlate with the known ability of periodontal ligament and regenerating tissue-derived fibroblasts to facilitate regeneration of the mineralized tissues of the periodontium...
  91. ncbi In vitro cartilage tissue engineering using cancellous bone matrix gelatin as a biodegradable scaffold
    Bo Yang
    College of Medicine, Xi an Jiaotong University, Yanta West Road, No 76, Yanta District, Xi an, Shaanxi Province 710061, People s Republic of China
    Biomed Mater 5:045003. 2010
    In this study, we constructed tissue-engineered cartilage using allogeneic cancellous bone matrix gelatin (BMG) as a scaffold. Allogeneic BMG was prepared by sequential defatting, demineralization and denaturation...
  92. ncbi BAPN dose dependence of mature crosslinking in bone matrix collagen of rabbit compact bone: corresponding variation of sonic velocity and equatorial diffraction spacing
    S Lees
    Bioengineering Department, Forsyth Dental Center, Boston, MA 02115
    Connect Tissue Res 24:95-105. 1990
    Crosslinking density in demineralized bone matrix collagen was found to depend on the beta-aminopropionitrile (BAPN) dose level for compact bone from rabbit femurs...
  93. ncbi Effect of hyperbaric oxygen on demineralized bone matrix and biphasic calcium phosphate bone substitutes
    Ahmed Jan
    Chief Resident in Oral and Maxillofacial Surgery and Anesthesia, University of Toronto, Toronto, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:59-66. 2010
    ..effect of hyperbaric oxygen (HBO) on the healing of critical-sized defects that were grafted with demineralized bone matrix (DBM) combined with Pluronic F127 (F127) to form a gel or putty, or a commercially available biphasic calcium ..
  94. ncbi Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse
    T Ohtsuki
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Calcif Tissue Int 63:167-72. 1998
    ..lesions and the intervertebral disk lesions of the twy mouse, we assessed the mRNA expression of noncollagenous bone matrix proteins such as osteocalcin, osteonectin, osteopontin, and matrix Gla protein (MGP) by in situ hybridization, ..
  95. ncbi Demineralised bone matrix in veterinary orthopaedics: a review
    J F Innes
    Musculoskeletal Research Group and Small Animal Teaching Hospital, Department of Comparative Molecular Medicine, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Cheshire, CH64 7TE, England
    Vet Comp Orthop Traumatol 23:393-9. 2010
    Demineralised bone matrix (DBM) is commonly used in human orthopaedics as an allograft prepared from cortical bone...
  96. ncbi Percutaneous reaming of simple bone cysts in children followed by injection of demineralized bone matrix and autologous bone marrow
    Anastasios D Kanellopoulos
    Department of Pediatric Orthopaedics, KAT Accident Hospital, Athens, Greece
    J Pediatr Orthop 25:671-5. 2005
    ..unicameral bone cysts using a combination of percutaneous reaming and injection of a mixture of demineralized bone matrix and autologous bone marrow. Follow-up ranged from 12 to 42 months (mean 28 months)...
  97. ncbi Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis
    J Schedel
    Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, Regensburg, Germany
    Scand J Immunol 60:514-23. 2004
    ..takes place, we investigated the adherence of SF from patients with OA and RA to different cartilage and bone matrix proteins...
  98. ncbi Dynamics of gene expression during bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro
    Elerin Kärner
    Center for Oral Biology, Institute of Odontology, Karolinska Institutet, P O Box 4064, SE 141 04 Huddinge, Sweden
    Biochim Biophys Acta 1790:110-8. 2009
    ..BMP2 induced the expression of principle osteogenic factors, such as osterix, bone sialoprotein and osteocalcin, whereas VEGF had the converse effect on the gene expression pattern...
  99. pmc Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation
    Harikiran Nistala
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10021, USA
    J Cell Biol 190:1107-21. 2010
    ..Together, these findings identify the extracellular microfibrils as critical regulators of bone formation through the modulation of endogenous TGF-β and BMP signaling...
  100. ncbi [Three-tunnels core decompression with implantation of bone marrow stromal cells (bMSCs) and decalcified bone matrix (DBM) for the treatment of early femoral head necrosis]
    Wei feng Ji
    Department of Orthopaedics and Traumatology, the Hospital of Zhejiang Province of TCM, Hangzhou 310006, Zhejiang, China
    Zhongguo Gu Shang 21:776-8. 2008
    ..3-tunnels core decompression with implantation of bone marrow stromal cells(bMSCs) and decalcified bone matrix (DBM) for treatment of femoral head necrosis in early stages, and to study its therapeutic results and ..
  101. ncbi Lumican is a major proteoglycan component of the bone matrix
    Afshin Raouf
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ont, Toronto, Canada
    Matrix Biol 21:361-7. 2002
    ..population of committed osteoprogenitors that in the presence of appropriate supplements form a mineralized bone matrix. The development of the MC3T3-E1 cells can be divided into three major stages, namely, proliferation, ..

Research Grants72

  1. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
  2. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..Wozney, et al., postulated that demineralized bone matrix (DBM) contains something that "contributes slow release/immobilization characteristics to BMP", thus "reducing ..
  3. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..Furthermore, the subsequent release of TGF[unreadable] from resorbed bone matrix propagates and accelerates bone loss by increasing osteoclastic bone resorption and inhibiting osteoblast ..
  4. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This project focuses on understanding the regulation of a bone matrix protein that is critical for the maintenance of bone mass...
  5. Novel Risk Factors for Vertebral Fractures in Health and Chronic Kidney Disease
    Julie Paik; Fiscal Year: 2013
    ..Current imaging techniques are unable to measure the bone matrix or mineralization, which may play important roles in fracture risk...
  6. Cthrc1 function as a novel TGF-beta antagonist in the vasculature
    Volkhard Lindner; Fiscal Year: 2013
    ..Transgenic mice overexpressing Cthrc1 have brittle bones due a lack of collagenous bone matrix, and their arteries are remarkably resistant to neointimal lesion formation upon injury...
  7. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..This research will elucidate the role of tooth/bone matrix material properties in oral and skeletal health and disease.
  8. Connexin 43 in Bone Remodeling
    Roberto Civitelli; Fiscal Year: 2013
    ..endocortical resorption and periosteal apposition, as well as a hypomineralized and structurally abnormal bone matrix, associated with down-regulation of osteoprotegerin (Opg) and Sost in Obl/Ocy...
  9. Assessing the Impact of Osteogenesis Imperfecta on Non-Skeletal Systems
    Laura Tosi; Fiscal Year: 2012
    ..disorder is caused by gene defects responsible for the production of Type I collagen, resulting in defective bone matrix and connective tissue...
  10. Sp7 Mediated Control of Runx2 Function for Osteoblast Differentiation
    Amjad Javed; Fiscal Year: 2013
    ..The Sp7 deficient mesenchymal cells do not deposit bone matrix and cannot differentiate into osteoblasts...
  11. Targeted delivery of osteoinductive molecules to biologic HA in bone grafts
    Jennifer L Bain; Fiscal Year: 2012
    ..The cellular bone matrix allograft will be cultured and MSCs will be seeded onto the acellular bone grafts and also cultured...
  12. Genetic Determinants of Physiological Responses to Fluoride in Bone
    Eric T Everett; Fiscal Year: 2012
    ..by applicant): Fluoride in various chemical forms and exposures has been repeatedly shown to have actions on bone matrix and on bone cells (osteoblasts and osteoclasts)...
  13. Optimizing Normal Collagen Replacement in Osteogenesis Imperfecta
    Sarah L Dallas; Fiscal Year: 2013
    ..Mice expressing the GFP-collagen construct show green fluorescent collagen in the bone matrix, tendon, intervertebral discs and skin and appear phenotypically normal...
  14. A megakaryocyte/PGE2/osteoblast triad in the normal and aged niche
    Louis M Pelus; Fiscal Year: 2013
    ..radiation, whether MKs stimulate OBs to function in support of hematopoiesis at the expense of synthesizing bone matrix. This would be a paradigm shift in the understanding of primary roles for both MKs and OBs and our ..
  15. Genetic Control of Osteoblast Differentiation
    Benoit de Crombrugghe; Fiscal Year: 2012
    ..precursor cells to become fully functioning osteoblasts, which synthesize and secrete the components of the bone matrix. Based on our preliminary results, we hypothesize that Osx continues to have a critical role in osteoblast and ..
  16. The Mechanistic Control of Bone Matrix Material Properties by TGF-beta and Runx2
    TAMARA N ALLISTON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone matrix is an organic and mineral composite that confers toughness and hardness to bone...
  17. Enhancement of Fracture Repair by Hematopoietic Stem Cells
    Amanda C LaRue; Fiscal Year: 2013
    ..cells with the capacity to differentiate to functional osteoblasts that deposit and mineralize extracellular bone matrix. Given the close association of bone and bone marrow (BM), it has been suggested that BM may serve as a source ..
  18. Human Embryonic Stem Cells in Calcium Phosphate Constructs for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2013
    ..MSCs encapsulated in degradable microbeads and incorporated into CPC will synthesize the most amount of bone matrix, followed by hUCMSCs...
  19. Targeted Correction of Dominant Mutations of Type I Collagen Causing Severe OI
    David W Rowe; Fiscal Year: 2013
    ..The study of OI mutations has shown that the disease results not only from an improperly organized bone matrix that is continually undergoing remodeling (high turnover bone) but also from impaired matrix production due to ..
  20. PDGF D AND PROSTATE CANCER BONE METASTASIS
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ..Bone resorption by osteoclasts results in the release of growth factors and cytokines from the bone matrix, providing a favorable microenvironment for tumor cell proliferation and invasion...
  21. Assessing and modifying bone quality in chronic kidney disease
    Chris Newman; Fiscal Year: 2013
    ..mechanical properties, mineralization, collagen composition (cross-linking, morphology, and mechanics), and bone matrix hydration (MRI)...
  22. Collagen Diversity and Pathobiology in Skeletal Tissues
    David R Eyre; Fiscal Year: 2013
    ..I. Such findings will also be significant for understanding qualitative changes in bone matrix that add significant risk of osteoporotic fracture in the population as a whole and a potential for novel ..
  23. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    Sarah L Dallas; Fiscal Year: 2013
    ..We will for the first time dynamically image the assembly process by which key bone matrix proteins are deposited in living bone cells and determine how the motile properties of the cells contribute to ..
  24. Osteoblast and Odontoblast Specific Regulatory Action of Runx2 for Bone and Tooth
    MITRA D ADHAMI; Fiscal Year: 2013
    ..This research will elucidate the role of tooth/bone matrix material properties in oral and skeletal health and disease...
  25. Bisphosphonate-related osteonecrosis of the jaw: Bridging the clinical-preclinica
    Matthew R Allen; Fiscal Year: 2010
    ..In a preclinical model our laboratory has shown the existence of necrotic bone matrix within the mandible (as opposed to the presence of exposed bone as seen clinically with BRONJ) following ..
  26. Wear Particle Disease and NF-kappa B Signaling
    Stuart B Goodman; Fiscal Year: 2013
    ..OPC cultures will be assayed for alkaline phosphatase and osteocalcin expression, and bone matrix formation will be quantitated using Von Kossa staining...
  27. Transgenic Approaches to Evaluate IGF-I Role in Peak BMD
    Subburaman Mohan; Fiscal Year: 2013
    ..levels of TH during second week of prepuberal growth period promotes conversion of chondrocytes in the SOC into bone matrix producing chondroblast/osteoblast cells via Osx-dependent mehcanism and thereby initiate bone formation...
  28. FGF2 Isoforms in Bone and Phosphate Homeostasis
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..ii) regulates bone matrix mineralization via FGF23 dependent and independent effects...
  29. BMP-3 Signaling in the Formation and Regulation of Bone
    Vicki Rosen; Fiscal Year: 2009
    ..First, although BMP3 is the most abundant BMP in bone, accounting for over 65% of the total BMP stored in bone matrix, little is known about its biology...
  30. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2012
    ..We also showed that maspin specifically binds to type I collagen, the most abundant protein in bone matrix. While maspin stabilized PC cell attachment to type I collagen, type I collagen further enhanced the maspin-..
  31. Development of Spectroscopic Biomarkers of Bone Quality in Metastatic Disease
    Xiaohong Bi; Fiscal Year: 2013
    ..The structural and compositional properties of the bone matrix will be assessed for intact non-tumor and tumor-bearing bones using a fiber optic probe interfaced Raman ..
  32. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    SARAH DALLAS; Fiscal Year: 2009
    ..abstract_text> ..
  33. An MRI-Based Method for Measuring Bone Mineral and Matrix Densities in Humans
    Alan C Seifert; Fiscal Year: 2013
    ..Therefore, the ratio of bone constituent densitie (RBCD), given as the ratio of bone mineral density to bone matrix density, would be a suitable metric by which to distinguish these two groups of diseases...
  34. Role of SIRT6 in calcific aortic valve disease
    Jordan D Miller; Fiscal Year: 2013
    ..Recent work, however, described the presence of osteoblast-like cells, osteoclast-like cells, and bone matrix in calcified aortic valves, which suggests that valve calcification is an active, potentially modifiable ..
  35. P30 Center in Craniofacial Bone Biology
    Nicola C Partridge; Fiscal Year: 2010
    ..They will be recruited in osteoclast biology, and osteocytes and their interaction with bone matrix to complement Dr. Partridge's and the existing faculty members'areas of research...
  36. The Mechanism of Coupling Bone Resorption and Formation
    Xu Cao; Fiscal Year: 2010
    ..bone is accomplished by precise coordination between two cell types: osteoblasts, which deposit the calcified bone matrix;and osteoclasts, which resorb bone...
  37. Regulation of osteoblast number by PTH
    Robert L Jilka; Fiscal Year: 2013
    ..resorption, which in turn increases osteoblast number via release of pro-osteogenic growth factors from the bone matrix, or via secretion of growth factors from osteoclasts themselves, or both...
  38. Black Bear Parathyroid Hormone as an Anabolic Agent for Bone
    SETH WARNER DONAHUE; Fiscal Year: 2011
    ..promote a greater anabolic response in bone than human PTH by decreasing osteoblast apoptosis and increasing bone matrix production by altering gene expression...
  39. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva P Kotha; Fiscal Year: 2012
    ..Osteocytes, cells embedded in the bone matrix, are thought to be responsible for sensing and coordinating adaptive responses in the skeleton...
  40. Solute Transport in the Bone Lacunar-Canalicular System
    Liyun Wang; Fiscal Year: 2012
    ..Since osteocytes are completely encased in mineralized bone matrix, their survival and function are entirely dependent on transport of solutes (metabolites, growth factors, ..
  41. NLRP3 inflammasome Regulation of Bone Resorption
    Gabriel Mbalaviele; Fiscal Year: 2013
    ..Finally, bone matrix degradation products activate NLRP3, and stimulate OC formation, implying that this inflammasome may be active ..
  42. Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing
    Sheldon Weinbaum; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteocytes, the cells that reside within bone matrix, are the most abundant bone cells...
  43. The Roles of Collagen and Water in the Fracture Resistance of Bone
    JEFFRY STEPHEN NYMAN; Fiscal Year: 2013
    ..Addressing these needs, the proposal aims to determine the extent to which water that is bound to the bone matrix and water residing in bone pores, as determined by Nuclear Magnetic Resonance (NMR), explain bone's ..
  44. Role of Vwc2-assisted activin signaling in bone formation
    Yoshiyuki Mochida; Fiscal Year: 2010
    ..gene expression is associated with early osteoblast differentiation, and that the Vwc2 protein is present in bone matrix and preferentially localized at the bone surface...
  45. Mechanobiology of 3D Trabecular Bone Explants
    X Edward Guo; Fiscal Year: 2013
    ..OCY) are intrinsically three-dimensional (3D), mature bone cells encased in 3D mineralized extracellular bone matrix. Recent studies indicate the critical roles of osteocytes in detecting mechanical signals and maintaining ..
  46. Control of Bone Formation by PKA Signaling in Osteocytes
    Richard Kao; Fiscal Year: 2010
    ..provided by applicant): Osteocytes are terminally differentiated osteoblasts that are imbedded in the bone matrix and are thought to initiate the skeletal response to mechanical strain...
  47. Thrombopoietin: A novel regulator of bone healing
    Melissa A Kacena; Fiscal Year: 2013
    ..biodegradable scaffolds with bone inducing factors such as bone morphogenetic proteins (BMPs) and demineralized bone matrix, missing bone tissue in segmental defects or non-unions can be healed...
  48. Viscoelastic deformation of bone matrix in postmenopause
    Do Gyoon Kim; Fiscal Year: 2010
    ..As the mineral in bone plays a role in maintaining mechanical strength of the bone matrix, decreases in mineral content leads to weaker bone...
  49. Role of Microstructure in Nanomechanical Behavior of Bone Tissue
    Marjolein C van der Meulen; Fiscal Year: 2010
    ..composition with tissue mechanical properties for treatments that result in well-established alterations in bone matrix composition and altered whole bone strength to test the following hypotheses: Hypothesis 1: Reduced bone ..
  50. Development of iPS cells to study craniometaphyseal dysplasia in humans
    ERNST J REICHENBERGER; Fiscal Year: 2010
    ..control and CMD iPS clones into osteoblasts in culture and analyze their potential for differentiation and bone matrix deposition in detail with a broad range of methods...
  51. Matrix-assisted Craniofacial Bone Regeneration
    Mitsuo Yamauchi; Fiscal Year: 2012
    ..Towards this end, this study will explore a novel approach to efficient and cost-effective craniofacial bone regeneration based on a unique function of bone matrix molecule, biglycan.
  52. Elucidating the Relationship Between Notch and WNT Signaling in Bone Formation
    COURTNEY MICHAEL KARNER; Fiscal Year: 2013
    ..Osteoblasts are the primary cell type responsible for producing bone matrix and are necessary not only for bone development but also bone remodeling and homeostasis...
  53. Diffuse microdamage in bone: Direct repair without remodeling
    Mitchell B Schaffler; Fiscal Year: 2012
    ..than does not involve bone remodeling, and we will also examine how osteocytes, the bone cells that live buried within the bone matrix, might participate in the direct repair of these very small cracks and prevent bone fragility.
  54. Bone matrix proteins in prostate cancer progression
    Pradip Roy Burman; Fiscal Year: 2010
    ..Two such functions are the focus of this proposal. These molecules, both secretory and commonly referred to as bone matrix proteins, are: osteopontin (OPN), an RGD-containing glycosylated phosphoprotein, and osteogenic protein-1 (OP-1 ..
  55. Genetic Mechanisms of Cranial Bone Development
    LAWRENCE H GOODNOUGH; Fiscal Year: 2013
    ..Cranial bone progenitors, primitive cells destined to become the bone matrix-secreting osteoblasts, require specific cues from inter-cellular signaling pathways for fate selection, ..
  56. The Role of MMP-13 in the TGF-beta Regulation of Bone Matrix Material Properties
    SIMON YUE CHEONG TANG; Fiscal Year: 2012
    ..Some aspects of bone quality are reflected through bone micro-architecture, microdamage accumulation, and bone matrix material properties (BMMP), and each has been shown to contribute significantly to bone fragility...
  57. Lysyl Oxidase Control of TGF-? in Bone
    Mitsuo Yamauchi; Fiscal Year: 2010
    ..with a potent growth factor, transforming growth factor-[unreadable]1 (TGF-[unreadable]1), in vitro and in bone matrix. In addition, LOX appears to suppress the TGF-[unreadable]1 signaling likely through its amine oxidase activity...
  58. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2001
    ..An osteoclast-specific cysteine proteinase, cathepsin K, plays a specialized role in the resorption of organic bone matrix. It was shown that cathepsin K inhibitors (CKI) are effective in reducing osteoclast-mediated bone resorption ..
  59. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..An osteoclast-specific cysteine proteinase, cathepsin K, plays a specialized role in the resorption of organic bone matrix. It was shown that cathepsin K inhibitors (CKI) are effective in reducing osteoclast-mediated bone resorption ..
  60. Role of Microenvironmental-Derived AXII in Myeloma Bone Disease
    GARSON DAVID ROODMAN; Fiscal Year: 2013
    ..of growth factors and angiogenic factors such as AXII by OCL and release of MM growth factors from the bone matrix. Further, release of AXII from bone marrow stromal cells and OCL increases production of cytokines by MM cells ..
  61. 3D IN VIVO MORPHOMETRY OF TRABECULAR MICROSTRUCTURE
    Nancy E Lane; Fiscal Year: 2013
    ..if there is an association between the changes in biochemical markers and surface-based bone turnover, bone matrix composition, and localized and whole bone material properties with long term sequential therapies;ARs followed ..
  62. CELL AND GENE THERAPY IN A MOUSE MODEL OF HUMAN OSTEOGEN
    Christopher Niyibizi; Fiscal Year: 2000
    ..from normal donor mice transplanted into syngeneic OI mice to synthesize and deposit normal type I collagen in bone matrix of the recipient mice and (2), to test the feasibility of gene therapy by demonstrating that bone marrow ..
  63. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..The hypotheses are that certain FGFs released from bone matrix (FGF2), the suture cells, and the dura mater (other that FGF2 or 7) diffuse to the extracellular matrix of the ..
  64. Development of a biodegradable load-bearing DBM carrier
    TIEN MIN CHU; Fiscal Year: 2006
    ..bone in large segmental bone defects using a load-bearing, biodegradable carrier carrying demineralized bone matrix (DBM)...
  65. BONE MARROW TRANSPLANTATION IN OIM--A GENE THERAPY MODEL
    DANIEL MC BRIDE; Fiscal Year: 2001
    ..cell type responsible for the biosynthesis, secretion, and orderly deposition of type 1 collagen and other bone matrix elements...
  66. Mechanotransduction in Osteocytic Network and Osteoblast
    X Guo; Fiscal Year: 2007
    ..Osteocytes are intrinsically three-dimensional (3D) bone cells that are encased in mineralized extracellular bone matrix and interconnected with each other as well as osteoblasts through numerous intercellular processes by gap ..
  67. Novel Bone Graft Material With Osteoinductive and Hemostatic Function
    Bo Han; Fiscal Year: 2009
    ..As an osteoinductive bone graft material, demineralized bone matrix (DBM) has emerged as an effective alternative to autograft...
  68. HOMOCYSTEINE MODIFIES BONE MATRIX AND MINERALIZATION
    CHARLES PRINCE; Fiscal Year: 2007
    ..modification, we will also experiment investigate conditions that result in the incorporation of Hcy into bone matrix proteins...
  69. BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATION
    JEFFREY GORSKI; Fiscal Year: 2003
    ..into supramolecular microfibrillar complexes, serves as a structural framework defining the volume of primary bone matrix to be subsequently calcified...
  70. EVALUATION OF CELLULAR GENE THERAPY FOR OI
    Christopher Niyibizi; Fiscal Year: 2001
    ..donor mice transplanted into syngeneic OI mice to engraft, synthesize and deposit normal type I collagen in bone matrix of the recipient mice and (2), to test the feasibility of gene therapy by evaluating the potential of bone ..
  71. PARATHYROID HORMONE REGULATION OF OSTEOBLASTIC MRNA
    Nicola Partridge; Fiscal Year: 1993
    ..The essential mechanisms underlying the remodelling process have to do with the regulation of bone matrix synthesis and degradation...
  72. PROTEOMIC ANALYSIS OF OSTEOCYTES
    Norman Karin; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Osteocytes arise from osteoblasts that become surrounded by bone matrix and form a junctionally-connected sensory network that transduces physical strain into signals that maintain bone mass and ..