Summary: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

Top Publications

  1. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  2. ncbi Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    Catalin Toma
    Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 105:93-8. 2002
  3. pmc Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    Masaki Ieda
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 142:375-86. 2010
  4. ncbi Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
  5. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
  6. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
  7. pmc Cardiac telocytes - their junctions and functional implications
    Mihaela Gherghiceanu
    Electron Microscopy Laboratory, Department of Advanced Studies, Victor Babes National Institute of Pathology, Bucharest, Romania
    Cell Tissue Res 348:265-79. 2012
  8. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
  9. pmc Oxygen, oxidative stress, hypoxia, and heart failure
    Frank J Giordano
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Invest 115:500-8. 2005
  10. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005

Detail Information

Publications326 found, 100 shown here

  1. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..When injected into an ischemic heart, these cells or their clonal progeny reconstitute well-differentiated myocardium, formed by blood-carrying new vessels and myocytes with the characteristics of young cells, encompassing ..
  2. ncbi Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    Catalin Toma
    Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 105:93-8. 2002
    Cellular cardiomyoplasty has been proposed as an alternative strategy for augmenting the function of diseased myocardium. We investigated the potential of human mesenchymal stem cells (hMSCs) from adult bone marrow to undergo myogenic ..
  3. pmc Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    Masaki Ieda
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 142:375-86. 2010
    ..Reprogramming of endogenous or explanted fibroblasts might provide a source of cardiomyocytes for regenerative approaches...
  4. ncbi Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
    ..This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice...
  5. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    ..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation...
  6. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
  7. pmc Cardiac telocytes - their junctions and functional implications
    Mihaela Gherghiceanu
    Electron Microscopy Laboratory, Department of Advanced Studies, Victor Babes National Institute of Pathology, Bucharest, Romania
    Cell Tissue Res 348:265-79. 2012
    ..This integrated interstitial system appears to be composed of large homotropic zones (TC-TC junctions) and limited (distinct) heterotropic zones (heterocellular junctions of TCs)...
  8. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
    ..Together, our studies suggest a molecular mechanism in which miRNAs participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development...
  9. pmc Oxygen, oxidative stress, hypoxia, and heart failure
    Frank J Giordano
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Invest 115:500-8. 2005
  10. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
    ..Herein, we report the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium. A cardiac mesenchymal feeder layer allows renewal of the isolated progenitor cells with maintenance of their ..
  11. ncbi Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    Francis G Spinale
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Physiol Rev 87:1285-342. 2007
  12. ncbi Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    Alessandra Moretti
    Massachusetts General Hospital Cardiovascular Research Center, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 127:1151-65. 2006
  13. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
    ..Furthermore, spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function...
  14. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  15. doi Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages
    Lei Bu
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 460:113-7. 2009
    ..These results lay the foundation for the generation of human model systems for cardiovascular disease and novel approaches for human regenerative cardiovascular medicine...
  16. doi Myocardial fatty acid metabolism in health and disease
    Gary D Lopaschuk
    Cardiovascular Research Group, Mazankowski Alberta Heart Institute, University of Alberta, Alberta T6G 2S2, Canada
    Physiol Rev 90:207-58. 2010
    ..The implications of inhibiting fatty acid beta-oxidation as a potential novel therapeutic approach for the treatment of various forms of heart disease are also discussed...
  17. pmc T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region
    Nadine Kawel
    Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:27. 2012
    ..The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time and ECV including magnetic field strength, cardiac phase and myocardial region...
  18. pmc Human cardiac stem cells
    Claudia Bearzi
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 104:14068-73. 2007
    ..We have established the conditions for the isolation and expansion of c-kit-positive hCSCs from small samples of myocardium. Additionally, we have tested whether these cells have the ability to form functionally competent human ..
  19. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
    ..ECV) may be able to detect subtle abnormalities such as diffuse fibrosis or post-infarct remodelling of remote myocardium. The aims were (1) to measure ECV in myocardial infarction and non-ischaemic myocardial fibrosis, (2) to ..
  20. pmc Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis
    C G Manole
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Cell Mol Med 15:2284-96. 2011
  21. ncbi Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning
    Zhi qing Zhao
    Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center Crawford Long Hospital, Emory University School of Medicine 550 Peachtree Street NE, Atlanta, GA 30308 2225, USA
    Am J Physiol Heart Circ Physiol 285:H579-88. 2003
    ..min-1.g tissue-1) in the area at risk myocardium was comparably reduced in Post-con (10.8 +/- 5.5, P < 0.05) and Pre-con (13.4 +/- 3.4, P < 0...
  22. pmc MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
    Kathryn N Ivey
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell Stem Cell 2:219-29. 2008
    ..Our findings indicate that muscle-specific miRNAs reinforce the silencing of nonmuscle genes during cell lineage commitment and suggest that miRNAs may have general utility in regulating cell-fate decisions from pluripotent ES cells...
  23. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    After administration of gadolinium, infarcted myocardium exhibits delayed hyperenhancement and can be imaged using an inversion recovery (IR) sequence...
  24. pmc A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    J D Molkentin
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center at Dallas, 75225 9148, USA
    Cell 93:215-28. 1998
    In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of fetal cardiac genes...
  25. ncbi The failing heart--an engine out of fuel
    Stefan Neubauer
    Department of Cardiovascular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 356:1140-51. 2007
  26. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
    In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic myocardium through paracrine effects that can be further augmented with preconditioning...
  27. pmc Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression
    Yao Liang Tang
    Stem Cell Biology, Keck Graduate Institute, Claremont, CA, USA
    Circ Res 104:1209-16. 2009
    ..progenitor) cells and markedly augmented CLK cell migration (in vitro) and recruitment (in vivo) to the ischemic myocardium. Four weeks after surgically induced myocardial infarction, infarct size and heart function were significantly ..
  28. pmc Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    I Kehat
    Cardiovascular Research Laboratory, Department of Physiology and Biophysics, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
    J Clin Invest 108:407-14. 2001
    ..Establishment of this unique differentiation system may have significant impact on the study of early human cardiac differentiation, functional genomics, pharmacological testing, cell therapy, and tissue engineering...
  29. pmc Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method
    Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:63. 2012
    ..The goal of this study was to develop and evaluate an automated method for producing a pixel-wise map of ECV that would be adequately robust for clinical work flow...
  30. pmc Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
    Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:64. 2012
    ..We hypothesized that quantitative assessment of myocardial ECV would be clinically useful for detecting both focal and diffuse myocardial abnormalities in a variety of common and uncommon heart diseases...
  31. pmc Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality
    Timothy C Wong
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Circulation 126:1206-16. 2012
  32. pmc Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II
    Feifei Ma
    Beijing An Zhen Hospital, Affiliated to Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China
    PLoS ONE 7:e35144. 2012
    ..Taken together, our results indicate that macrophages stimulate cardiac fibroblasts to produce IL-6, which leads to TGF-β1 production and Smad3 phosphorylation in cardiac fibroblasts and thus stimulates cardiac fibrosis...
  33. pmc Role of microRNAs in the reperfused myocardium towards post-infarct remodelling
    Hongyan Zhu
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Cardiovasc Res 94:284-92. 2012
    ..of highly conserved small (∼18-24 nucleotide) non-coding RNAs, fulfil specific functions in the reperfused myocardium towards post-infarct remodelling...
  34. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
    ..The aim of this study was to determine whether cardiac magnetic resonance (CMR) in vivo T1 mapping can measure myocardial area at risk (AAR) compared with microspheres or T2 mapping CMR...
  35. pmc Cardiomyocytes can be generated from marrow stromal cells in vitro
    S Makino
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 103:697-705. 1999
    ..These cells expressed Nkx2.5/Csx, GATA4, TEF-1, and MEF-2C mRNA before 5-azacytidine treatment and expressed MEF-2A and MEF-2D after treatment. This new cell line provides a powerful model for the study of cardiomyocyte differentiation...
  36. ncbi Isolation and expansion of adult cardiac stem cells from human and murine heart
    Elisa Messina
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Circ Res 95:911-21. 2004
  37. pmc Myocardial T1 and extracellular volume fraction mapping at 3 tesla
    Jason J Lee
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 13:75. 2011
    ..To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV)...
  38. ncbi Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
    D Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 105:851-62. 2001
    ..Myocardin is the founding member of a class of muscle transcription factors and provides a mechanism whereby SRF can convey myogenic activity to cardiac muscle genes...
  39. doi Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    Leah Iles
    Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Coll Cardiol 52:1574-80. 2008
    ..The purpose of this study was to investigate a noninvasive method for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI)...
  40. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
    ..of the remodeling process, the capillary network is unable to support the greater demands of the hypertrophied myocardium, resulting in progressive loss of viable tissue, infarct extension and fibrous replacement...
  41. pmc Transient regenerative potential of the neonatal mouse heart
    Enzo R Porrello
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 331:1078-80. 2011
    ..Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate...
  42. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
    ..However, only if subsequent MPTP closure occurs will ATP levels be maintained, ensuring that cell death continues down an apoptotic, rather than a necrotic, pathway...
  43. pmc Cardiac autophagy is a maladaptive response to hemodynamic stress
    Hongxin Zhu
    Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Clin Invest 117:1782-93. 2007
    ..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention...
  44. ncbi Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish
    Chiu Ju Huang
    Institute of Molecular and Cell Biology, National Taiwan University, Taipei, Taiwan
    Dev Dyn 228:30-40. 2003
  45. ncbi Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    Christine Mummery
    Hubrecht Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 107:2733-40. 2003
    ..Here, we induced cardiomyocyte differentiation of hES cells by a novel method and compared their electrophysiological properties and coupling with those of primary human fetal cardiomyocytes...
  46. ncbi Monitoring of bone marrow cell homing into the infarcted human myocardium
    Michael Hofmann
    Department of Nuclear Medicine, Hanover Medical School, Hanover, Germany
    Circulation 111:2198-202. 2005
    ..Although the mechanisms of this effect remain to be established, homing of BMCs into the infarcted myocardium is probably a critical early event.
  47. pmc Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    Cardiovasc Res 87:431-9. 2010
  48. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ..The full text of this article is available at http://www.
  49. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    ..occurs through robust proliferation of cardiomyocytes localized at the leading epicardial edge of the new myocardium. The hearts of zebrafish with mutations in the Mps1 mitotic checkpoint kinase, a critical cell cycle regulator, ..
  50. doi Oxidative stress and left ventricular remodelling after myocardial infarction
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cardiovasc Res 81:457-64. 2009
    In acute myocardial infarction (MI), reactive oxygen species (ROS) are generated in the ischaemic myocardium especially after reperfusion. ROS directly injure the cell membrane and cause cell death...
  51. pmc Transmural dispersion of repolarization in failing and nonfailing human ventricle
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Circ Res 106:981-91. 2010
    ..Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important contributor to the HF phenotype. However, there is limited electrophysiological data from the human heart...
  52. ncbi Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    Michael A Laflamme
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Nat Biotechnol 25:1015-24. 2007
    ..The engrafted human myocardium attenuated ventricular dilation and preserved regional and global contractile function after myocardial ..
  53. ncbi Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
    Massimiliano Gnecchi
    Nat Med 11:367-8. 2005
  54. pmc Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
    Márta Sárközy
    Cardiovascular Research Group, Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Cardiovasc Diabetol 12:16. 2013
    ..Therefore, we examined the possible alterations in cardiac gene expression pattern in male Zucker Diabetic Fatty (ZDF) rats, a model of metabolic syndrome...
  55. doi The innate immune response in reperfused myocardium
    Leo Timmers
    Department of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Cardiovasc Res 94:276-83. 2012
    ..Our future challenge lies within the counteraction of maladaptive inflammatory cascades, without interfering in the benign wound healing response, and in translating these anti-inflammatory strategies into clinical practice...
  56. doi Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    Kevin Bersell
    Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Cell 138:257-70. 2009
    ..Undifferentiated progenitor cells did not contribute to NRG1-induced cardiomyocyte proliferation. Thus, increasing the activity of the NRG1/ErbB4 signaling pathway may provide a molecular strategy to promote myocardial regeneration...
  57. ncbi Control of stress-dependent cardiac growth and gene expression by a microRNA
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 316:575-9. 2007
    ..Thus, the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208...
  58. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
  59. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  60. pmc Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Disease Program, Oregon Health and Science University, Portland, Ore, USA
    Circ Cardiovasc Imaging 3:727-34. 2010
    ..the etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood. Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI...
  61. pmc Diabetic cardiomyopathy, causes and effects
    Sihem Boudina
    Division of Endocrinology Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, 15 North 2030 East, Bldg 533 Room 3110B, Salt Lake City, UT 84112, USA
    Rev Endocr Metab Disord 11:31-9. 2010
    ..The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected ..
  62. ncbi Uncoupling proteins in human heart
    Andrew J Murray
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    Lancet 364:1786-8. 2004
    ..New treatment to correct these energy defects would be to simultaneously lower plasma free fatty acids and provide an alternative energy source...
  63. ncbi Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure
    E J Lesnefsky
    Division of Cardiology, Case Western Reserve University and Geriatric Research, Education and Clinical Center, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Mol Cell Cardiol 33:1065-89. 2001
    ..Finally, the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) is addressed...
  64. doi Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology
    Michel Ovize
    Service d Explorations Fonctionnelles Cardiovasculaires and Inserm U886, Hospices Civils de Lyon, University of Lyon, France
    Cardiovasc Res 87:406-23. 2010
  65. doi Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options
    Ashish Aneja
    The Mount Sinai Cardiovascular Institute, New York, NY 10029, USA
    Am J Med 121:748-57. 2008
    ..imaging technologies also have permitted the detection of subtle systolic dysfunction in the diabetic myocardium. In the early stages, these changes appear reversible with tight metabolic control, but as the pathologic ..
  66. ncbi Cardiac hypertrophy: the good, the bad, and the ugly
    N Frey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Annu Rev Physiol 65:45-79. 2003
    ..In this review, we summarize recent insights into hypertrophic signaling and consider several novel antihypertrophic strategies...
  67. pmc Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions
    Mihaela Gherghiceanu
    Victor Babes National Institute of Pathology, Bucharest, Romania
    J Cell Mol Med 15:1005-11. 2011
    b>Myocardium is composed of two main cell populations: cardiomyocytes (CMs) and interstitial cells (e.g. fibroblasts, immunoreactive cells, capillaries)...
  68. doi miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling
    Rudy F Duisters
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Circ Res 104:170-8, 6p following 178. 2009
    The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis...
  69. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
    ..Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans...
  70. pmc Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    K A Jackson
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 107:1395-402. 2001
    ..3%, primarily in small vessels adjacent to the infarct. Our results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction...
  71. pmc Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Lancet 379:895-904. 2012
    Cardiosphere-derived cells (CDCs) reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models...
  72. doi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  73. pmc T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison
    Neville Gai
    Radiology and Imaging Sciences, Clinical Center, and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    Magn Reson Med 65:1407-15. 2011
    ..Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state...
  74. ncbi Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium
    Flora Sam
    Myocardial Biology Unit, Boston University School of Medicine, Boston Medical Center, MA 02118, USA
    J Card Fail 11:473-80. 2005
    ..The nature of oxidative stress and the activity of antioxidant enzyme systems are incompletely characterized in the failing human heart...
  75. ncbi Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of
    Young Sup Yoon
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 111:2073-85. 2005
    ..Diabetic cardiomyopathy (DCM) is characterized by microvascular pathology and interstitial fibrosis, which leads to progressive heart failure; however, the pathogenesis of DCM remains uncertain...
  76. doi Biology of endoplasmic reticulum stress in the heart
    Jody Groenendyk
    Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circ Res 107:1185-97. 2010
    ..ER proteins and ER stress-associated pathways may play a role in the development of novel UPR-targeted therapies for cardiovascular diseases...
  77. pmc Cardiac myosin binding protein C phosphorylation is cardioprotective
    Sakthivel Sadayappan
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16918-23. 2006
    ..These data demonstrate that cMyBP-C phosphorylation functions in maintaining thick filament spacing and structure and can help protect the myocardium from ischemic injury.
  78. pmc Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
    S Varma Penumathsa
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    J Cell Mol Med 12:2350-61. 2008 we examined resveratrol (RSV)-mediated Glut-4 translocation in the streptozotocin (STZ)-induced diabetic myocardium. The rats were randomized into three groups: Control (Con), Diabetes Mellitus (DM) (STZ 65 mg/kg b.w., i.p...
  79. ncbi Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
    ..would be similar to the T2-weighted hyperintense region observed 2 days later, that the T2-weighted hyperintense myocardium would show partial functional recovery after 2 months, and that the T2 abnormality would resolve over 2 months.
  80. doi Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans
    Guo Kun Wang
    Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, People s Republic of China
    Eur Heart J 31:659-66. 2010
    ..We aim to determine the potential of cardiac-specific miRNAs in circulation to serve as biomarkers for acute myocardial infarction (AMI)...
  81. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
  82. ncbi Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies
    M Zhang
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    J Mol Cell Cardiol 33:907-21. 2001
    ..Recent studies indicate that cardiomyocyte grafting forms new myocardium in injured hearts...
  83. doi Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy
    Rory O'Hanlon
    Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Foundation Trust, London, UK
    J Am Coll Cardiol 56:867-74. 2010
    ..We investigated the significance of fibrosis detected by late gadolinium enhancement cardiovascular magnetic resonance for the prediction of major clinical events in hypertrophic cardiomyopathy (HCM)...
  84. pmc On T2* magnetic resonance and cardiac iron
    John Paul Carpenter
    Royal Brompton and Harefield NHS Trust, London, SW3 6NP, UK
    Circulation 123:1519-28. 2011
  85. ncbi Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response
    Jeannette Nussbaum
    Department of Pathology, University of Washington, Seattle, WA, USA
    FASEB J 21:1345-57. 2007
    ..Successful cardiac repair strategies involving ES cells will need to control cardiac differentiation, avoid introducing undifferentiated cells, and will likely require immune modulation to avoid rejection...
  86. ncbi Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial
    Kai C Wollert
    Department of Cardiology, Hanover Medical School, Hanover, Germany
    Lancet 364:141-8. 2004
    ..In this randomised trial, we aimed to assess whether intracoronary transfer of autologous bone-marrow cells could improve global left-ventricular ejection fraction (LVEF) at 6 months' follow-up...
  87. ncbi CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation
    Otmar Pfister
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 97:52-61. 2005
  88. pmc Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells
    Tao Sheng Li
    Cedars Sinai Heart Institute, Los Angeles, California, USA
    J Am Coll Cardiol 59:942-53. 2012
    ..The goal of this study was to conduct a direct head-to-head comparison of different stem cell types in vitro for various assays of potency and in vivo for functional myocardial repair in the same mouse model of myocardial infarction...
  89. doi Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
    Hans Erik Bøtker
    Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark
    Lancet 375:727-34. 2010
    ..We tested the hypothesis that remote ischaemic conditioning during evolving ST-elevation myocardial infarction, and done before primary percutaneous coronary intervention, increases myocardial salvage...
  90. doi Characterising the myocardial interstitial space: the clinical relevance of non-invasive imaging
    Steven K White
    The Heart Hospital, 16 18 Westmoreland Street, London, UK
    Heart 98:773-9. 2012
  91. ncbi Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management
    Genzou Takemura
    Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Prog Cardiovasc Dis 49:330-52. 2007
    ..We suggest this approach to preventing DOX-induced cardiomyopathy is worthy of serious consideration for clinical use...
  92. pmc Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology
    Annarosa Leri
    Departments of Anesthesia and Medicine, and Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 109:941-61. 2011
    ..Several categories of cardiac progenitors have been described but, thus far, the c-kit-positive cell is the only class of resident cells with the biological and functional properties of tissue specific adult stem cells...
  93. ncbi Pathogenesis of chronic Chagas heart disease
    Jose Antonio Marin-Neto
    Cardiology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Circulation 115:1109-23. 2007
    ..Despite nearly 1 century of research, the pathogenesis of chronic Chagas cardiomyopathy is incompletely understood, the most intriguing challenge of which is the complex host-parasite interaction...
  94. pmc Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction
    Erica Dall'Armellina
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 14:15. 2012
  95. ncbi In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
    Dara L Kraitchman
    Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287 0845, USA
    Circulation 107:2290-3. 2003
    ..We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model...
  96. pmc A novel mouse model of lipotoxic cardiomyopathy
    H C Chiu
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Clin Invest 107:813-22. 2001
    ..This novel mouse model will provide insight into the role of perturbations in myocardial lipid metabolism in the pathogenesis of inherited and acquired forms of heart failure...
  97. ncbi PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
    S O Marx
    Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 101:365-76. 2000
    ..6, PKA, the protein phosphatases PP1 and PP2A, and an anchoring protein, mAKAP. In failing human hearts, RyR2 is PKA hyperphosphorylated, resulting in defective channel function due to increased sensitivity to Ca2+-induced activation...
  98. pmc NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease
    Monisha Dhiman
    Department of Microbiology and Immunology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Pathol 225:583-96. 2011
    ..cruzi infection, and bystander effects of heart-infiltrating phagocytes and CD8(+) T cells resulting in cardiac remodelling in chagasic mice...
  99. ncbi Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    Ding An
    Div of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The Univ of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 291:H1489-506. 2006
  100. ncbi The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes
    Chaoqian Xu
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150086, People s Republic of China
    J Cell Sci 120:3045-52. 2007
    ..Post-transcriptional repression of HSP60 and HSP70 by miR-1 and of caspase-9 by miR-133 contributes significantly to their opposing actions...
  101. pmc HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
    W C Claycomb
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 95:2979-84. 1998
    ..HL-1 cells represent a cardiac myocyte cell line that can be repeatedly passaged and yet maintain a cardiac-specific phenotype...

Research Grants78

  1. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010 characterize alterations in mitochondrial signaling occurring with aging and E2 deficiency in the female rat myocardium following chronic ethanol ingestion...
  2. Right ventricular contractile dysfunction after pressure overload
    ..Agents with potential clinical utility will be identified using the isolated papillary muscle model and tested in the pig model. ..
  3. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Impaired insulin signaling in the myocardium may contribute to cardiac dysfunction in obesity, type 2 diabetes and other insulin resistant states...
  4. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..The knowledge obtained from this investigation should be useful for the development of better treatment for heart failure, ischemic injury and stem cell therapy. ..
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Several intracellular PLA2s are expressed in heart, including cPLA2 and iPLA2 . Diabetic myocardium is characterized by an increase in the expression and activity of cPLA2 and iPLA , which liberate free fatty ..
  6. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..concentrations by chronic PTH elevations has known deleterious physiological effects within the vasculature and myocardium such as vasoconstriction, activation of fibroblasts, insulin resistance, dyslipidemia, fat deposition and down ..
  7. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..such as coronary artery disease, hypertension, diabetes, infection, or inflammation results in a heterogeneous myocardium consisting of a mixture of replacement fibrosis, dysfunctional and normal myocytes...
  8. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
  9. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..Importantly, hypertrophy develops in the surviving myocardium after an acute infarct to counterbalance increased hemodynamic load;and ischemia due to lack of angiogenesis is ..
  10. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ..These studies will establish the role of myocardium-localized versus BM-localized GSTP in the process of remodeling, neovascularization, and inflammation in the ..
  11. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..crosstalk, TGF2 expression, and extensive fibrosis in the conduction system (and, in some, the surrounding myocardium) of CHB-hearts, provided in vivo support for parallel in vitro investigation...
    Vijay Sharma; Fiscal Year: 2013
    ..demonstrating high myocardial first pass extraction, rapid clearance from the liver, retention within the myocardium to enable delayed imaging, and based on isotopes that could potentially be generator-produced on site (rather ..
  13. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..However, it is limited by donor availability and transplant rejection. Recently, regeneration of infracted myocardium by injecting stem cells has been proposed as an alternative therapy...
  14. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..hypertrophy;[2] To investigate the in vivo role of GRK2 in dysfunctional myocardial glucose uptake of ischemic myocardium and to determine the cellular mechanisms in myocytes of how GRK2 regulates glucose metabolism and insulin ..
  15. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
    ..However, repair of injured myocardium remains a serious challenge...
  16. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..lipid species formed from oxidation of lipids, play a fundamental role in the greater propensity of diabetic myocardium for oxidative stress injury and resultant HF after MI...
  17. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Background: Hibernating myocardium is viable, persistently dysfunctional myocardium that occurs in response to continuing or repetitive myocardial ischemia and is characterized by hypoperfusion ..
  18. Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    HUA LINDA CAI; Fiscal Year: 2013
    ..Characterization of the CMEC-cardiomyocyte signaling axis may additionally provide novel insights into potential cell-based therapies. ..
    Sung Wan Kim; Fiscal Year: 2012
    ..However, cardiomyocyte protection and vessel collateralization of the myocardium is not primarily affected...
    Devendra K Agrawal; Fiscal Year: 2013
    ..adipose tissue (EAT) is present in close proximity to the adventitia of the coronary arteries and the underlying myocardium, and functions as both endocrine organ and inflammatory tissue, secreting hormones, cytokines and chemokines...
  21. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..The p.D300N is associated with degenerative disease involving myocardium, conduction system, valves and the coronary arteries, while the p...
  22. Oxygen versus PAP for treatment of sleep apnea in chronic heart failure
    Henry Klar Yaggi; Fiscal Year: 2013 sleep apnea, which may contribute to progression of myocardial dysfunction through both direct effects on the myocardium and through elevation of blood pressure;it stimulates the generation of reactive oxygen species, which may ..
  23. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ..We also showed that "selective insulin resistance" also exists in the myocardium of diabetic or insulin resistant rodents, which could be responsible for the decreases in VEGF expression and ..
  24. Role of Lipoproteins in Chagasic heart disease
    ..Immunofluorescence analysis demonstrated an accumulation of LDL around parasites in the myocardium of infected mice...
  25. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    ..human, suggesting that an alteration in SLN /SERCA ratio could contribute to altered Ca2+ transport in failing myocardium. Based on these findings, we hypothesize that SLN is a key mediator of 2-adrenergic response in the atria and ..
  26. Modulation of Ca Control of Cardiac Myofibrils
    R John Solaro; Fiscal Year: 2013 this proposal that demonstrated that expression of ssTnI in the adult heart of transgenic mice protects the myocardium against common stresses including familial dilated cardiomyopathy (DCM)...
  27. Thyroid-adrenergic synergism and adaptive thermogenesis
    Antonio C Bianco; Fiscal Year: 2013
    ..of the spectrum, the D3 pathway terminates TH action, decreasing energy expenditure as we have shown in hypoxic myocardium and brain...
    Anthony Carruthers; Fiscal Year: 2012
    ..g. brain, peripheral nerve, myocardium, retina) and that GLUT1 is uniquely amenable to acute catalytic regulation...
  29. Striated Muscle Gene Transcription and Regulatory Gene Cassettes for Gene Therapy
    ..Improved regulatory cassette activity decreases the number of viral vectors needed for patient treatment, thereby increasing safety and decreasing viral production costs. ..
  30. Contractile Regulation of Cardiocyte Protein Synthesis
    Paul J McDermott; Fiscal Year: 2013 applicant): Partial or complete occlusion of a coronary artery creates ischemia, thereby exposing the myocardium to either an insufficient supply of oxygen (hypoxia) or a complete lack of oxygen (anoxia)...
  31. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..Studies will also investigate the effects of H2S on the induction of antioxidant signaling pathways in the myocardium prior to MI-R. Specific Aim 3: To investigate the role of the RISK pathway in H2S-mediated cardioprotection...
  32. Cardiomyocyte Zinc and its Regulation of Contraction-Relaxation Function
    Bradley M Palmer; Fiscal Year: 2012
    ..Using chemically-skinned myocardium, we will measure the myofilament tension vs...
  33. Silencing cardiac-specific microRNAs to prevent pathological remodeling in conges
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2011
    ..Demonstrating hypertrophy and fibrosis in the miR-208 expressing myocardium, coupled with PK/PD data, will permit compelling efficacy assessments in phase II to enable rapid advancement of ..
  34. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    ..In the infarcted myocardium, loss of contractile myocardium and blood vessels is induced by MI...
  35. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013 that timed release of MGF and IGF-1 delivered locally by the MRS regenerates and strengthens the damaged myocardium without harmful side effects...
  36. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..therapy which upregulates endothelial progenitor cells (EPCs) and specifically targets them to ischemic myocardium. This post- infarction angiogenic therapy to augment myocardial microcirculation will study three specific aims: ..
  37. Ca2+ and ROS Crosstalk Signaling in Cardiac Mitochondria
    Shey Shing Sheu; Fiscal Year: 2013
    ..It is our objective, not only to make a scientific contribution to oxidative stress-mediated disease mechanisms, but also to develop possible therapeutic means for treating these debilitating disorders. ..
  38. Regulation of IL-6-Type Cytokine Cardioprotective Signaling in the Ischemic Heart
    George W Booz; Fiscal Year: 2012
    ..Our research is focused on understanding how that cascade is turned on and off with the hope that this knowledge could be used therapeutically to prevent ischemic damage to the heart. ..
  39. The Role of RAGE in Diabetes and Myocardial Infarction.
    KAREN O'SHEA; Fiscal Year: 2013
    ..mDia, both highly upregulated in the murine heart after I/R, signal devastating metabolic consequences in the myocardium, which trigger mitochondrial dysfunction...
  40. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting C Zhao; Fiscal Year: 2012
    ..ischemia, ischemia/reperfusion and chronic myocardial infarction: We will measure HDAC activity in ischemic myocardium in both acute ischemia, ischemia/reperfusion and chronic myocardial infarction...
  41. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..heart failure remain unclear, but may be related to progressive contractile dysfunction of the region of viable myocardium that surrounds the infarct (border zone, BZ)...
  42. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..The end result of our efforts will be an intravenously delivered protein therapy for patients with MCD1A, DMD and LGMD2C-F...
  43. Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA Supplementation
    LAURA JANE DEN HARTIGH; Fiscal Year: 2013
    Michael Regnier; Fiscal Year: 2013
    ..Results from these studies will provide valuable insight on whether sustained enhancement of myofilament contractility (with dATP) has potential for treatment of heart failure in animal models and humans. ..
  45. Myocardial Injury Associated with Mitochondria-derived Oxygen Free Radical(s)
    Yeong Renn Chen; Fiscal Year: 2013
    ..whether irreversible protein S- sulfonation of NQR and SQR is induced in the mitochondria of the post-ischemic myocardium. The protein sulfonation marked in the NQR and SQR after myocardial infarction will be characterized by mass ..
  46. Cellular Mechanisms of Lymphatic Muscle Contractility
    MICHAEL JOHN DAVIS; Fiscal Year: 2012
    ..These studies will investigate which proteins allow these vessels to contract so that specific therapeutic agents can be developed to correct lymphatic pump dysfunction and drainage of edematous tissues. ..
  47. Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2013
    ..activation of post-conditioning protective pathways and myocardial injury responses in ischemic and non-ischemic myocardium will also be determined...
  48. Nitrite Mediated Cardioprotection
    DAVID JOSEPH LEFER; Fiscal Year: 2012
    ..I/R injury whereas the overexpression of eNOS, NO donor or inhaled NO gas therapy significantly protect the myocardium. NO possesses a number of physiological properties that makes it a potent cardioprotective-signaling molecule...
  49. Development of an In Vivo Stem Cell Tracking Method Using Ultrasound Imaging
    Flordeliza S Villanueva; Fiscal Year: 2010
    ..reparative treatments for the heart, and led to the exploration of therapeutic delivery of stem cells to injured myocardium. In animal studies of acute myocardial infarction, delivery of cell preparations such as unfractionated adult ..
  50. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    ..Oxygen delivery to the myocardium is flow dependent and myocardial ischemia may be precipitated by low hemoglobin concentrations...
  51. Regulation of Age-Associated Heterochromatin Formation
    Jill Kreiling; Fiscal Year: 2013
    ..Taken together this project will broaden our understanding of the mechanisms and processes involved in the regulation of age- associated heterochromatin formation. ..
  52. Stem cells and the fibroblast/adipocyte lineage in arrhythmogenic cardiomyopathy
    Karen L Vikstrom; Fiscal Year: 2010
    ..cardiac disease characterized by severe ventricular arrhythmias, as well as progressive replacement of healthy myocardium with fibrous and fatty tissue leading in many cases to severe heart failure and, in the absence of a heart ..
  53. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..Changes in the CK system are seen in heart failure in both the human and animal myocardium indicative of impaired delivery of ATP to energy consuming systems...
  54. Membrane-associated PDE3-binding proteins in human myocardium
    Matthew A Movsesian; Fiscal Year: 2013
    ..To identify the proteins that interact with membrane-associated PDE3 isoforms in human myocardium: PDE3A-binding proteins in purified high-density microsomes from human left ventricular myocardium will be co-..
  55. Calcium Signaling, Metabolism, and EC Coupling in Heart
    Joshua I Goldhaber; Fiscal Year: 2013
    ..This will lead to new therapeutic strategies for preserving heart muscle function, thereby reducing the incidence of heart failure. ..
  56. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2013
    ..This study will examine how FHC mutations in one of the proteins of the heart (the myosin regulatory light chain), alters the ability of the heart to generate force and power at the molecular level. ..
  57. Role of the Giant Protein Titin in Skeletal Muscle Structure and Function
    Henk L Granzier; Fiscal Year: 2013
    ..We hope that ultimately larger muscle masses can be maintained as a result of our studies on the role of titin in hypertrophy signaling. ..
  58. Regulation of Hepatic Carbohydrate Metabolism by STBD1
    Alan Cheng; Fiscal Year: 2012
    ..Importantly, this can ultimately identify novel therapeutic avenues in these diseases. ' ..
  59. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2013
    ..We will also examine whether Epo adminstration induces PKD activation in vivo in myocardium and, if so, which EpoR-associated elements contribute to this signaling...
  60. Protein Kinase C Isozymes in Ischemic Heart
    Daria Mochly-Rosen; Fiscal Year: 2013
    ..recent discoveries by a number of other labs identified the importance of the mitochondria in the health of the myocardium. The mitochondria are critical for cardiac metabolism and energetics as well as for cell death through apoptosis ..
  61. Cardiac metabolism and heart failure
    Rong Tian; Fiscal Year: 2010
    ..obesity, metabolic syndrome or high sympathetic activity can lead to accumulation of active lipid metabolites in myocardium causing lipotoxicity...
  62. Myocardial salvage via coordinated induction of endogenous cardiac antioxidants
    Yunbo Li; Fiscal Year: 2010
    ..ischemia- reperfusion injury via enhancing the coordinated expression of the endogenous antioxidant network in myocardium. The long-term objective of this project is to develop a highly effective endogenous antioxidant- based ..
  63. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..and parasympathetic modulation of heart rate, conduction of the specialized conduction system and ventricular myocardium, AP upstroke velocity, APDs, DOR, and Cai transients will be analyzed during various autonomic nerve stimulation ..
  64. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..A major portion of this injury is due to reperfusion and inflammation of the myocardium and may involve portions of the myocardium which can be salvaged from irreversible injury...
    MARC VISNER; Fiscal Year: 1991
    ..The unifying hypothesis for this work is that TNFalpha interacts directly with the myocardium, so that within 24 hours, there are derangements in intracellular physiology that either compromise contractile ..
    Sonia Pearson White; Fiscal Year: 1992
    JASWANT BHORJEE; Fiscal Year: 1990
    ..William Claycomb...
    Julio Perez; Fiscal Year: 1999
    ..The overall goal of the proposed research is the development and validation of an approach for detection of viable myocardium noninvasively with quantitative ultrasonic imaging techniques that can be performed at the bedside, repeated as ..
  69. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
    ..Depth-Resolved Imager (HSDRI) to map electrical activity or intracellular free Ca 2+ transients inside the myocardium of perfused hearts. The partnership consists of 3 groups. Dr...
    David Warltier; Fiscal Year: 1990
    ..The long term goal is an in-depth analysis of actions and mechanisms by which anesthetic agents affect ischemic myocardium. The majority of previous investigations elucidating the cardiovascular pharmacology of anesthetic agents has ..
  71. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2005
    ..that mitochondria, in addition to maintaining the energy stores for the high work demands of ventricular myocardium, play a role in determining the cell's transition from reversible injury to apoptosis and necrosis...
    Edward McFalls; Fiscal Year: 2000
    ..Secondly, we hypothesize that within chronically hypoperfused myocardium, myocardium retains the capacity to regenerate high energy phosphates and glycogen stores...
    Douglas Mann; Fiscal Year: 1991
    ..accomplish two goals: first, they will focus future research regarding the contractile defect in hypertrophied myocardium either on the cardiac muscle cell itself, or the cardiac muscle cell within its interstitium; second they will ..
  74. Targeted Delivery of Cardioprotective Drugs
    Marina V Backer; Fiscal Year: 2010
    ..To limit infarct size and improve functional recovery, the ischemic myocardium has to be reperfused...
  75. Restoring LV Function Post-MI Using Fibrin-Gel Based Engineered Myocardium
    Lauren Black; Fiscal Year: 2009
    ..Only heart transplantation replaces infarcted myocardium to restore heart function, but there is a paucity of donor hearts and the incidence of cardiovascular disease ..
    Kiran Sagar; Fiscal Year: 1990
    Ultrasonic tissue characterization of myocardium is a promising application of ultrasound to the diagnosis of cardiac disease. Several problems need to be resolved before tissue characterization can be used clinically...
  77. HTS for Regulated Muscle Thin Filament Function.
    JAMES DOUGLAS POTTER; Fiscal Year: 2010
    ..Results from these studies will ultimately be beneficial in developing new therapeutic approaches for the treatment of these and potentially other forms of cardiovascular disease. ..
  78. Stem cell-based therapy in heart failure: aging effects
    Mohamed Gaballa; Fiscal Year: 2003
    ..incorporation into the injured tissue, as well as decrease in cytokines/chemokines secreted by the injured myocardium. In addition, clinically, the dysfunction in bone marrow derived endothelial progenitor cells was shown to ..