Genomes and Genes
Summary: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of skeletal muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.
Publications274 found, 100 shown here
- Truncation of the carboxyl terminus of the dihydropyridine receptor beta1a subunit promotes Ca2+ dependent excitation-contraction coupling in skeletal myotubesDavid C Sheridan
Department of Physiology, University of Wisconsin School of Medicine, Madison, 53706, USA
Biophys J 84:220-37. 2003..The studies underscore the essential role of the carboxyl terminus region of the DHPR beta1a subunit in fast voltage dependent EC coupling in skeletal myotubes...
- Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cellsGary P Kobinger
Gene Therapy Program, Division of Medical Genetics, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Hum Gene Ther 14:1441-9. 2003..this concept, we selected a mouse model of muscular dystrophy (mdx mice) that undergoes rapid turnover of muscle fibers. In vivo targeting of muscle progenitor cells, notably satellite cells, with a pseudotyped lentiviral vector ..
- Effects of ovariectomy and estrogen on skeletal muscle function in growing ratsKathleen M McCormick
Department of Exercise and Nutrition Sciences, University of Buffalo, State University of New York, Buffalo, New York 14214, USA
J Muscle Res Cell Motil 25:21-7. 2004..This reduction was not accompanied by a change in myosin heavy chain composition implying that calcium handling may have been altered. Results from this study suggest that estrogen affects skeletal muscle growth and twitch kinetics...
- Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivityMichael J Toth
Department of Medicine, University of Vermont, Burlington, VT 05405, United States
Int J Cardiol 107:211-9. 2006..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity...
- The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factorsTrevor N Stitt
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Mol Cell 14:395-403. 2004....
- Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblastsMaurilio Sampaolesi
Stem Cell Research Institute, H. S. Raffaele, Via Olgettina 58, 20132 Milan, Italy
Science 301:487-92. 2003..The success of this protocol was mainly due to widespread distribution of donor stem cells through the capillary network, a distinct advantage of this strategy over previous approaches...
- Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibersAshok Kumar
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
FASEB J 18:102-13. 2004Dystrophin is a cytoskeletal protein found at the inner surface of skeletal and cardiac muscle fibers. We hypothesize that deficiency of dystrophin increases muscle compliance and causes an aberrant mechanotransduction in muscle fibers...
- Cell lineage tracing during Xenopus tail regenerationCesare Gargioli
Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
Development 131:2669-79. 2004..This shows that metaplasia between differentiated cell types does not occur, and that the process of Xenopus tail regeneration is more akin to tissue renewal in mammals than to urodele tail regeneration...
- Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regenerationAnna Polesskaya
Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
Cell 113:841-52. 2003..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
- Skeletal muscle repair by adult human mesenchymal stem cells from synovial membraneCosimo De Bari
Laboratory for Skeletal Development and Joint Disorders, Dept. of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
J Cell Biol 160:909-18. 2003..When administered into dystrophic muscles of immunosuppressed mdx mice, hSM-MSCs restored sarcolemmal expression of dystrophin, reduced central nucleation, and rescued the expression of mouse mechano growth factor...
- Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-kappaBA S Whitehouse
Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
Br J Cancer 89:1116-22. 2003..The results further suggest that EPA may attenuate protein degradation induced by PIF, at least partly, by preventing NF-kappaB accumulation in the nucleus...
- Normal myoblast fusion requires myoferlinKatherine R Doherty
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
Development 132:5565-75. 2005..These data support a role for myoferlin in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes...
- Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1Takashi Kimura
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
Hum Mol Genet 14:2189-200. 2005..We suggest that aberrant splicing of RyR1 and SERCA1 mRNAs might contribute to impaired Ca2+ homeostasis in DM1 muscle...
- A muscleblind knockout model for myotonic dystrophyRahul N Kanadia
Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, Gainesville, FL 32610, USA
Science 302:1978-80. 2003..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA...
- Voltage-dependent dynamic FRET signals from the transverse tubules in mammalian skeletal muscle fibersMarino DiFranco
Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Gen Physiol 130:581-600. 2007..membrane potential changes in the transverse tubular system (TTS) and surface membranes of adult mice skeletal muscle fibers. Farnesylated EGFP or ECFP (EGFP-F and ECFP-F) were used as immobile FRET donors, and either non-fluorescent (..
- Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophyThea Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, 35, Stirling Highway, Crawley, Perth, WA 6009, Australia
Neuromuscul Disord 15:139-46. 2005..It is proposed that the protective effect of mIGF-1 on denervated myofibres might be due to reduced protein breakdown...
- Structural differentiation of skeletal muscle fibers in the absence of innervation in humansSimona Boncompagni
Interuniversitary Institute of Miology, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
Proc Natl Acad Sci U S A 104:19339-44. 2007..Most importantly, the recovery occurs in the complete absence of motor and sensory innervation and of nerve-derived trophic factors, that is, solely under the influence of muscle activity induced by electrical stimulation...
- IGF-1 induces human myotube hypertrophy by increasing cell recruitmentV Jacquemin
CNRS UMR 7000 Cytosquelette et Développement, Paris, France
Exp Cell Res 299:148-58. 2004..In addition, muscle hypertrophy can be triggered in the absence of proliferation by recruiting more mononucleated cells. We propose that IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle...
- Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophyAmi Mankodi
Department of Neurology, School of Medicine and Dentistry, University of Rochester, Box 673, 601 Elmwood Avenue, New York 14642, USA
Mol Cell 10:35-44. 2002..We propose that a transdominant effect of mutant RNA on RNA processing leads to chloride channelopathy and membrane hyperexcitability in DM...
- Depletion "skraps" and dynamic buffering inside the cellular calcium storeBradley S Launikonis
Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, 1750 West Harrison Street, Suite 1279JS, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 103:2982-7. 2006..When store depletion becomes widespread, the polymers would collapse to increase store [Ca2+] and sustain the concentration gradient that drives release flux...
- Regulation of mitochondrial biogenesis in skeletal muscle by CaMKHai Wu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 296:349-52. 2002..Thus, a calcium-regulated signaling pathway controls mitochondrial biogenesis in mammalian cells...
- Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibersFrançois Xavier Boittin
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
J Cell Sci 119:3733-42. 2006..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
- Endurance training induces muscle-specific changes in mitochondrial function in skinned muscle fibersYan Burelle
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Appl Physiol 92:2429-38. 2002....
- Molecular mechanisms and therapeutics of the deficit in specific force in ageing skeletal muscleOsvaldo Delbono
Department of Physiology and Pharmacology, Department of Internal Medicine, Gerontology and Neuroscience Program, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Biogerontology 3:265-70. 2002..The molecular, functional and structural factors supporting this theory and counteracting measures such as insulin-like growth factor 1 transgenic overexpression are discussed...
- Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophyAshok Kumar
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
FASEB J 17:386-96. 2003..Our results show that mechanical stretch activates the classical NF-kappaB pathway and this pathway could be predominately active in DMD...
- Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibersThomas J Hawke
School of Kinesiology and Health Science, York Univ, 4700 Keele St, Toronto ON Canada
Am J Physiol Cell Physiol 293:C1636-44. 2007..Taken together, the present findings support the hypothesis that Xin is expressed within muscle satellite cells during skeletal muscle regeneration and is involved in the regulation of myoblast function...
- Induction of cachexia in mice by systemically administered myostatinTeresa A Zimmers
Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Science 296:1486-8. 2002..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...
- Intracellular acidosis enhances the excitability of working muscleThomas H Pedersen
Department of Physiology, University of Aarhus, DK-8000, Denmark
Science 305:1144-7. 2004..These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue...
- Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null miceMarco A P Brotto
Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Cell Res 14:373-8. 2004..we investigated the properties of Ca2+-uptake and -release in toxin-skinned Extensor Digitorium Longus (EDL) muscle fibers from control and mg29 knockout mice...
- Ultrastructure of mouse striated muscle fibers following pravastatin administrationMichael Bergman
Department of Medicine 'C, Rabin Medical Center, Golda Campus, 7, Keren Kayemet St, Petah Tiqva, Israel
J Muscle Res Cell Motil 24:417-20. 2003..While the ultrastructure of the heart and liver of the treated animals appeared normal, the muscle fibers showed a marked alterations of the mitochondria, which were increased in size compared to those of the ..
- Role of protein kinase C and NF-kappaB in proteolysis-inducing factor-induced proteasome expression in C(2)C(12) myotubesH J Smith
Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
Br J Cancer 90:1850-7. 2004..This suggests that PKC may be involved in the phosphorylation and degradation of I-kappaBalpha, induced by PIF, necessary for the release of NF-kappaB from its inactive cytosolic complex...
- Impaired regeneration of dystrophin-deficient muscle fibers is caused by exhaustion of myogenic cellsM A M Luz
Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil
Braz J Med Biol Res 35:691-5. 2002Duchenne muscular dystrophy is one of the most devastating myopathies. Muscle fibers undergo necrosis and lose their ability to regenerate, and this may be related to increased interstitial fibrosis or the exhaustion of satellite cells...
- Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expressionKwok On Lai
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, People s Republic of China
J Biol Chem 279:13383-92. 2004..In addition, the present study provides the first demonstration of a potential function of Eph receptors and Jak/Stat proteins at the NMJ...
- Firing rates of motor units during strong dynamic contractionsAlejandro Del Valle
The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Florida 33136, USA
Muscle Nerve 32:316-25. 2005..Thus, protective mechanisms may limit motor unit firing rates during forceful lengthening contractions to minimize damage...
- The adaptive potential of skeletal muscle fibersDirk Pette
Department of Biology, University of Konstanz, Germany
Can J Appl Physiol 27:423-48. 2002Mammalian skeletal muscle fibers display a great adaptive potential...
- Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regenerationKoichi Ojima
Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan
Biochem Biophys Res Commun 321:1050-61. 2004..Taken together, our data suggest that neither HSCs nor mature inflammatory cells, but Mac-1(low) early myeloid cells in the BM-derived SP fraction, play an important role in regenerating skeletal muscles...
- Intracellular PO2 kinetics at different contraction frequencies in Xenopus single skeletal muscle fibersRichard A Howlett
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
J Appl Physiol 102:1456-61. 2007Increasing contraction frequency in single skeletal muscle fibers has been shown to increase the magnitude of the fall in intracellular Po(2) (Pi(O(2))), reflecting a greater metabolic rate...
- Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifyllineJean François Rolland
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
Neurobiol Dis 24:466-74. 2006..The possibility to pharmacologically counteract abnormal channel activity discloses important therapeutic application...
- Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeysNolan G Gokey
University of Wisconsin, Department of Animal Health and Biomedical Sciences, Madison, WI 53706, USA
Aging Cell 3:319-26. 2004..deletion mutations co-localize with electron transport system (ETS) abnormalities in rhesus monkey skeletal muscle fibers. Using laser capture microdissection in conjunction with PCR and DNA sequence analysis, mitochondrial genomes ..
- BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injuryKambiz Mousavi
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Am J Physiol Cell Physiol 287:C22-9. 2004..known to result in an extensive loss of lumbar motor neurons as well as the disappearance of their respective muscle fibers in the hindlimb musculature...
- What controls the position, number, size, and distribution of neuromuscular junctions on rat muscle fibers?Terje Lømo
Department of Physiology, University of Oslo, Norway
J Neurocytol 32:835-48. 2003..that determine the position, number, size, and distribution of neuromuscular junctions (NMJs) on skeletal muscle fibers. Most of the data reviewed derive from studies of ectopic NMJ formation on soleus (SOL) muscle fibers in adult ..
- Relationship between force and stiffness in muscle fibers after stretchDilson E Rassier
Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 Univ Dr, Calgary, AB, Canada T2N 1N4
J Appl Physiol 99:1769-75. 2005..Because BDM places cross bridges in a weakly bound, pre-powerstroke state, our results further suggest that force enhancement is partially associated with a recruitment of weakly bound cross bridges into a strongly bound state...
- Junctional and extrajunctional acetylcholinesterase in skeletal muscle fibersNeva Crne-Finderle
Medical Faculty, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 157:23-7. 2005..Calcineurin signalling pathway seems to be involved...
- Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory moduleEun Hui Lee
Department of Anesthesia Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Cell Physiol 286:C179-89. 2004..Although we were unable to define the negative module using RyR1-RyR2 chimeras, they further demonstrated that the RyR is very sensitive to long-range allosterism...
- Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organizationStephane Dedieu
Laboratoire Biosciences de l Aliment, Universite Bordeaux I, ISTAB USC INRA 429, 33405 Talence Cedex, France
Exp Cell Res 292:187-200. 2004....
- Development of the neuromuscular junctionVeit Witzemann
Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
Cell Tissue Res 326:263-71. 2006..Following the production of muscle fibers, clusters of acetylcholine receptors (AChRs) are concentrated in the central regions of the myofibers via a ..
- Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signalingPatrick Steigemann
Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Goettingen, Germany
Curr Biol 14:225-30. 2004..The results suggest that Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells...
- Functional improvement of dystrophic muscle by myostatin blockadeSasha Bogdanovich
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Richards A 601, Philadelphia, Pennsylvania 19104 6085, USA
Nature 420:418-21. 2002....
- Apoptosis in heart and skeletal muscleAndy J Primeau
School of Kinesiology and Health Science, York University, Toronto, Ontario, M3J 1P3
Can J Appl Physiol 27:349-95. 2002..This review discusses the basic cellular mechanisms of apoptosis, as well as the current evidence of this process in cardiac and skeletal muscle. The need for more work in this area is highlighted, particularly in exercise and training...
- Regulated sarcolemmal localization of the muscle-specific ClC-1 chloride channelH Papponen
Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FIN 90014, Finland
Exp Neurol 191:163-73. 2005..These data indicate that sarcolemmal targeting of the ClC-1 requires specific signals that are provided by the physiological environment...
- Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouseElla W Yeung
School of Medical Sciences and Institute for Biomedical Research, University of Sydney F13, NSW 2006, Australia
J Physiol 562:367-80. 2005..This result suggests that blockers of stretch-activated channels may protect against muscle damage in the intact mdx mouse...
- Muscle satellite cellsJennifer E Morgan
Muscle Cell Biology Group, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Int J Biochem Cell Biol 35:1151-6. 2003..e. approximately 1 x 10(10) to 2 x 10(10) satellite cells per person. (2) Main functions: repair and maintenance of skeletal muscle. (3) Turnover rate: close to zero in non-traumatic conditions-high in disease or severe trauma...
- Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophySwarnali Acharyya
Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
J Clin Invest 117:889-901. 2007..IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers. Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model ..
- The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathyPhilipp Christoph Janiesch
Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
Nat Cell Biol 9:379-90. 2007....
- Effects of endurance training on satellite cell frequency in skeletal muscle of old menNadia Charifi
Laboratoire de Physiologie, , , Saint Etienne, France
Muscle Nerve 28:87-92. 2003..The enhancement of satellite cell frequency and fiber area indicate that endurance training is an efficient strategy to improve muscle function in the elderly...
- Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatinSimona Iezzi
Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 6:673-84. 2004....
- Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old miceJ C Bruusgaard
Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindern NO-0316, Oslo, Norway
J Appl Physiol 100:2024-30. 2006We have recently published a new technique for visualizing nuclei in living muscle fibers of intact animals, based on microinjection of labeled DNA into single myofibers, excluding satellite cells (Bruusgaard JC, Liestol K, Ekmark M, ..
- Nitric oxide-dependence of satellite stem cell activation and quiescence on normal skeletal muscle fibersAshley C Wozniak
Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Dev Dyn 236:240-50. 2007..Results have important implications for designing new therapies that target the role of exercise in health, aging, and disease...
- Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibersPietro Fratta
Department of Neurology, USC Neuromuscular Center, Good Samaritan Hospital, Los Angeles, CA 90017-1912, USA
Am J Pathol 167:517-26. 2005..ubiquitinated multiprotein-aggregates are characteristic of sporadic inclusion-body myositis (s-IBM) muscle fibers. Two major types of aggregates exist, containing either amyloid-beta (Abeta) or phosphorylated tau (p-tau)...
- Histochemical and immunohistochemical study on muscle fibers in human extraocular muscle spindlesWaltraut Wicke
Medical University of Vienna, Center of Anatomy and Cell Biology, Integrative Morphology Group, Waehringer Stasse 13, 1090 Vienna, and Institute of Pathology and Bacteriology, Kaiserin Elisabeth Hospital, Austria
Exp Eye Res 84:670-9. 2007..Aim of this study was to establish a classification of intrafusal muscle fibers of human extraocular muscles based on their histochemical and immunohistochemical properties and to determine ..
- Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetesMads K Holten
Department of Medical Physiology, The Panum Institute, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Diabetes 53:294-305. 2004..The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade...
- Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxideSandrine Arbogast
U KY, Lexington
Am J Physiol Regul Integr Comp Physiol 287:R698-705. 2004Free radicals are produced continuously by skeletal muscle fibers. Extracellular release of reactive oxygen species (ROS) and nitric oxide (NO) derivatives has been demonstrated, but little is known about intracellular oxidant regulation...
- Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibersJosh A Henkin
Department of Biology, University of Vermont, Burlington, VT 05405, USA
Am J Physiol Cell Physiol 286:C65-72. 2004..We propose that flightin is a major contributor to myofilament stiffness and a key determinant of the enhanced delayed force response to stretch in Drosophila flight muscles...
- Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regenerationD D W Cornelison
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
Genes Dev 18:2231-6. 2004..Further, syndecan-4(-/-) satellite cells fail to reconstitute damaged muscle, suggesting a unique requirement for syndecan-4 in satellite cell function...
- Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?Jingsong Zhou
Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
J Gen Physiol 124:409-28. 2004..It is proposed that relief of this inhibition could be the mechanism by which increased SR load increases spark frequency...
- Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycanGünther A Rezniczek
Max F Perutz Laboratories, Department of Molecular Cell Biology, University of Vienna, A 1030 Vienna, Austria
J Cell Biol 176:965-77. 2007..of plectin isoforms during myotube differentiation and their localization to different compartments of muscle fibers, identifying plectins 1 and 1f as sarcolemma-associated isoforms, whereas plectin 1d localizes exclusively to ..
- Regulation of muscle fiber type and running endurance by PPARdeltaYong Xu Wang
Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
PLoS Biol 2:e294. 2004..receptor delta (PPARdelta) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers. Treatment of wild-type mice with PPARdelta agonist elicits a similar type I fiber gene expression profile in ..
- Changes in muscle fiber conduction velocity indicate recruitment of distinct motor unit populationsC J Houtman
Department of Clinical Neurophysiology, Institute of Neurology, University Medical Centre, 6500 HB Nijmegen, The Netherlands
J Appl Physiol 95:1045-54. 2003..It is most likely that the MFCV pattern can be ascribed to the fatiguing of already recruited predominantly type I motor units, followed by the recruitment of fresh, predominantly type II, motor units...
- Muscle building; mechanisms of myotube guidance and attachment site selectionFrank Schnorrer
Institute of Molecular Biotechnology IMBA, Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Dev Cell 7:9-20. 2004..Much of this knowledge comes from studies in Drosophila, where powerful methods for in vivo imaging and genetic manipulation can be used to tackle this important but largely unsolved problem in developmental biology...
- Improvement of calcium handling and changes in calcium-release properties after mini- or full-length dystrophin forced expression in cultured skeletal myotubesEric Marchand
Institut de Physiologie et Biologie Cellulaire, UMR CNRS Université de Poitiers 6187, Pole Biologie Sante, 86022 Poitiers Cedex, France
Exp Cell Res 297:363-79. 2004Dystrophin is a cytoskeletal protein normally expressed underneath the sarcolemma of muscle fibers. The lack of dystrophin in Duchenne muscular Dystrophy (DMD) muscles results in fiber necrosis, which was proposed to be mediated by ..
- Mini-dystrophin restores L-type calcium currents in skeletal muscle of transgenic mdx miceO Friedrich
Medical Biophysics, Institute of Physiology and Pathophysiology, INF 326, Ruprecht Karls University, 69120 Heidelberg, Germany
J Physiol 555:251-65. 2004..This linkage seems to be fully restored in the presence of mini-dystrophin...
- Effects of running exercise during recovery from hindlimb unloading on soleus muscle fibers and their spinal motoneurons in ratsAkihiko Ishihara
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Neurosci Res 48:119-27. 2004..unloading and recovery with or without running exercise on morphological and metabolic properties of soleus muscle fibers and their spinal motoneurons in rats were investigated...
- Design and function of superfast muscles: new insights into the physiology of skeletal muscleLawrence C Rome
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Annu Rev Physiol 68:193-221. 2006..Hence the locomotory and sound-producing muscles have mutually exclusive designs...
- Myogenic fusion of human bone marrow stromal cells, but not hematopoietic cellsDaqing Shi
Fred Hutchinson Cancer Research Center, Division of Clinical Research, and Department of Pathology, University of Washington, Seattle, USA
Blood 104:290-4. 2004..nonobese diabetic-severe combined immunodeficient (NOD/SCID) beta 2m(-/-) mice resulted in regenerating mouse muscle fibers expressing GFP...
- Ca2+ sparks and T tubule reorganization in dedifferentiating adult mouse skeletal muscle fibersLisa D Brown
Biology Department, Morgan State University, Baltimore, MD, USA
Am J Physiol Cell Physiol 292:C1156-66. 2007..Here we used cultured adult mouse flexor digitorum brevis muscle fibers to monitor occurrence of Ca(2+) sparks during maintenance of adult fiber morphology and during eventual fiber ..
- Therapeutic clenbuterol treatment does not alter Ca2+ sensitivity of permeabilized fast muscle fibres from exercise trained or untrained horsesDavid R Plant
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
J Muscle Res Cell Motil 24:471-6. 2003..The results indicate that a therapeutic dose of clenbuterol to Standardbred horses does not affect the Ca(2+)-activated contractile characteristics of isolated muscle fibres...
- Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ releaseNoah Weisleder
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
J Cell Biol 174:639-45. 2006..This finding, coupled with decreased expression of MG29 in aged skeletal muscle, suggests that MG29 expression is important in maintaining skeletal muscle Ca2+ homeostasis during aging...
- Regulation of store-operated calcium entries and mitochondrial uptake by minidystrophin expression in cultured myotubesA Vandebrouck
Institut de Physiologie et Biologie Cellulaires, CNRS, UMR-6187, University of Poitiers, Poitiers, France
FASEB J 20:136-8. 2006..Forced expression of minidystrophin in dystrophic cells might restore the regulation of sarcolemmal store-dependent channels, which could protect against calcium mishandling...
- Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiationMichael S Huh
Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, K1H 8L6
J Cell Biol 166:865-76. 2004..Therefore, Rb plays a crucial role in the switch from proliferation to differentiation rather than maintenance of the terminally differentiated state...
- Altered inactivation of Ca2+ current and Ca2+ release in mouse muscle fibers deficient in the DHP receptor gamma1 subunitDaniel Ursu
University of Ulm, Dept of Applied Physiology, Albert Einstein Allee 11, D 89069 Ulm, Germany
J Gen Physiol 124:605-18. 2004..Data from single adult muscle fibers of gamma-/- mice are not yet available...
- Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatinDominique Joulia
Laboratoire Différenciation Cellulaire et Croissance, INRA, 2 place Viala, 34060 Montpellier Cedex 1, France
Exp Cell Res 286:263-75. 2003..Though some differences in overexpression or inhibition of endogenous myostatin were observed, it appears that myogenin and p21 are essential targets of this growth factor...
- A new surface electromyography analysis method to determine spread of muscle fiber conduction velocitiesFiete Lange
Department of Clinical Neurophysiology, University Hospital Groningen, 9700 RB Groningen, The Netherlands
J Appl Physiol 93:759-64. 2002..In conclusion, the IPL method provides accurate values for the MFCV and additionally gives information about the scatter of conduction velocities...
- High K(m) of oxidative phosphorylation for ADP in skinned muscle fibers: where does it stem from?Olav Kongas
Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center 1081 BT Amsterdam, The Netherlands
Am J Physiol Cell Physiol 283:C743-51. 2002..We conclude that the affinity to ADP of in situ mitochondria in heart is of the same order of magnitude as that of isolated mitochondria...
- Myopathy with lobulated muscle fibers: evidence for heterogeneous etiology and clinical presentationD Figarella-Branger
Service d Anatomie Pathologique et de Neuropathologie et Laboratoire de Biopathologie Nerveuse et Musculaire La Timone, IBDM, 27 Boulevard Jean Moulin, 13005 Marseille, France
Neuromuscul Disord 12:4-12. 2002....
- Characterization of the calcium release domains during excitation-contraction coupling in skeletal muscle fibresMarino DiFranco
Department of Physiology, UCLA School of Medicine, 10833 Le Conte Avenue 53-263 CHS, Los Angeles, CA 90095-1751, USA
Pflugers Arch 443:508-19. 2002..Our results are compatible with the possibility that action potential stimulation elicits Ca2+ release from a region of the sarcoplasmic reticulum (SR) broader than the T-SR junction...
- Inhibition of myostatin in adult mice increases skeletal muscle mass and strengthLisa Anne Whittemore
Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 300:965-71. 2003..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
- Glucocorticoid-mediated regulation of utrophin levels in human muscle fibersIsabelle Courdier-Fruh
MyoContract Pharmaceutical Research Ltd, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
Neuromuscul Disord 12:S95-104. 2002..We have also analyzed 66 glucocorticoids for their effect on utrophin protein levels and found that glucocorticoids in general are able to induce utrophin protein in human myotubes...
- Muscle fiber type is associated with obesity and weight lossCharles J Tanner
Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858, USA
Am J Physiol Endocrinol Metab 282:E1191-6. 2002..72, P < 0.005) between the percentage of excess weight loss and the percentage of type I fibers in morbidly obese patients. These findings indicate that there is a relationship between muscle fiber type and obesity...
- Metabolic regulation of Ca2+ release in permeabilized mammalian skeletal muscle fibresElena V Isaeva
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Physiol 547:453-62. 2003..Our results suggest that mitochondria exert a negative control over Ca2+ signalling in skeletal muscle by buffering Ca2+ near Ca2+ release channels...
- Distinct signaling pathways are activated in response to mechanical stress applied axially and transversely to skeletal muscle fibersAshok Kumar
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 277:46493-503. 2002..Taken together with the alterations of MAP kinases and the findings of elevations of downstream transcription targets, our data are consistent with two distinct MAP kinase signal transduction pathways in response to mechanical stress...
- Identification of a novel population of muscle stem cells in mice: potential for muscle regenerationZhuqing Qu-Petersen
Growth and Development Laboratory, Children's Hospital of Pittsburgh, Department of Orthopaedic Surgery, University of Pittsburgh, PA 15260, USA
J Cell Biol 157:851-64. 2002..Our results suggest that this novel population of muscle-derived stem cells will significantly improve muscle cell-mediated therapies...
- Ca(2+) influx and opening of Ca(2+)-activated K(+) channels in muscle fibers from control and mdx miceNora Mallouk
, UMR CNRS 5123, , 69622 Villeurbanne Cedex, France
Biophys J 82:3012-21. 2002Using the patch-clamp technique, we demonstrate that, in depolarized cell-attached patches from mouse skeletal muscle fibers, a short hyperpolarization to resting value is followed by a transient activation of Ca(2+)-activated K(+) ..
- Depolarization-induced contraction and SR function in mechanically skinned muscle fibers from dystrophic mdx miceDavid R Plant
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
Am J Physiol Cell Physiol 285:C522-8. 2003Dystrophin is absent in muscle fibers of patients with Duchenne muscular dystrophy (DMD) and in muscle fibers from the mdx mouse, an animal model of DMD...
- Early changes of type 2B fibers after denervation of rat EDL skeletal muscleElena Germinario
Dipartimento di Anatomia e Fisiologia Umana, Centro di Studio per la Biologia e la Fisiopatologia Muscolare, I-35131 Padova, Italy
J Appl Physiol 92:2045-52. 2002..Our results indicate that type 2B fiber functional properties are highly sensitive to the interruption of nerve supply. Moreover, most of 2-day-denervated changes were reverted at 7 days...
- Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body sizeJames O Marx
Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA
Pflugers Arch 452:222-30. 2006..These results suggest that limb length, not body mass, is a more relevant factor driving the scaling effect on skeletal muscle shortening velocity...
- Dependence of cross-bridge kinetics on myosin light chain isoforms in rabbit and rat skeletal muscle fibresOleg Andruchov
Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A-5020, Salzburg, Austria
J Physiol 571:231-42. 2006..Thus, the physiological role of fast and slow MLC isoforms in type IIA fibres is a fine-tuning of the cross-bridge kinetics...
- Neurovascular transfer does not cause skeletal muscle fiber degenerationKotaro Yoshimura
Department of Surgery, Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA
Plast Reconstr Surg 117:1455-61. 2006..Muscle fiber degeneration is not responsible for the force deficits observed after microneurovascular skeletal muscle transfer...
- Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic miceJonathan D Schertzer
Dept. of Physiology, The University of Melbourne, Victoria 3010, Australia
Am J Physiol Endocrinol Metab 291:E499-505. 2006....
- Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient miceMorikatsu Yoshida
Medical Chemistry and Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
J Biol Chem 280:3500-6. 2005..The results obtained demonstrate that SAR plays important roles in improving the Ca2+ handling functions of the SR in striated muscle...
- Myosin heavy chain isoform composition and stretch activation kinetics in single fibres of Xenopus laevis iliofibularis muscleOlena Andruchova
Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria
J Physiol 574:307-17. 2006..Thus, our results lay the foundation for the unequivocal classification of the muscle fibres in the Xenopus iliofibularis muscle and for gaining further insights into skeletal muscle fibre diversity...
- Correlation of average muscle fiber conduction velocity measured during cycling exercise with myosin heavy chain composition, lactate threshold, and VO2maxDario Farina
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Fredrik Bajers Vej 7 D 3, Aalborg University, DK 9220 Aalborg, Denmark
J Electromyogr Kinesiol 17:393-400. 2007..05). Instantaneous mean power spectral frequency was not correlated with any of these variables or with MFCV, thus questioning the use of surface EMG spectral analysis for indirect estimation of MFCV in dynamic contractions...
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2004..multiple nerves, each of which supplies a distinct region within the muscle, and that it contains specialized muscle fibers. One of these, slow tonic muscle fibers (STMF) has a unique physiology...
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2003..by staining to show details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor ..
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJulio L Vergara; Fiscal Year: 2010..This functional characterization will be achieved in muscle fibers from various animal models of human muscular dystrophies...
- Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC MutationsDanuta Szczesna Cordary; Fiscal Year: 2010..We will examine this hypothesis at the single molecule level in papillary muscle fibers from transgenic mouse hearts which carry disease-causing mutations in the regulatory and/or essential light ..
- MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZEPaul J May; Fiscal Year: 2010..motor neurons that control the lens and pupil, and the motor neurons that control the multiply innervated muscle fibers (MIFs) in the extraocular muscles. MIFs are highly fatigue resistant and tonically active...
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...
- Role of Type I Interferons in a Self-Sustaining Murine Model of MyositisThomas Griffin; Fiscal Year: 2007..excessive expression of MHC class I molecules and an associated unfolded protein response (UPR) in affected muscle fibers in each of these conditions suggests a common mechanism for chronic muscle fiber injury...
- Role of Troponin T Isoforms in Amish Nemaline MyopathyJian Ping Jin; Fiscal Year: 2007..are neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers Recent studies have identified a recessively inherited form of nemaline myopathy, the Amish nemaline myopathy (..
- ALPHA 7 BETA1 INTEGRIN AND MUSCLE INTEGRITYStephen Kaufman; Fiscal Year: 2000DESCRIPTION (adapted from investigator's abstract): The proper association of muscle fibers with their extracellular matrix is essential to the normal functioning of skeletal muscle...
- Role of actin domains in force generation in myocardiumMasataka Kawai; Fiscal Year: 2010..Our research involves selectively removing the thin filament from cardiac muscle fibers (myocardium) by gelsolin treatment, and sequentially reconstituting the thin filament with G-actin and the ..
- Role of actin domains in force generation in myocardiumMasataka Kawai; Fiscal Year: 2009..Our research involves selectively removing the thin filament from cardiac muscle fibers (myocardium) by gelsolin treatment, and sequentially reconstituting the thin filament with G-actin and the ..
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2007..Another important finding was that the adult pharyngeal muscles contained muscle fibers expressing unusual myosin heavy chain (MHC) isoforms (slow-tonic and alpha-cardiac) which were concentrated ..
- Impact of Exercise on SarcopeniaJudd Aiken; Fiscal Year: 2009..We have shown that age-dependent mtDNA deletion mutations clonally accumulate to high levels in aged skeletal muscle fibers. Concomitant with this increase in aberrant genomes is a loss of complex IV (cytochrome c oxidase; COX-) ..
- Impact of Exercise on SarcopeniaJudd M Aiken; Fiscal Year: 2010..We have shown that age-dependent mtDNA deletion mutations clonally accumulate to high levels in aged skeletal muscle fibers. Concomitant with this increase in aberrant genomes is a loss of complex IV (cytochrome c oxidase;COX-) ..
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...
- Spectroscopy of myosin light chain domain dynamicsOsha Roopnarine; Fiscal Year: 2010..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
- SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTORSTEVEN BURDEN; Fiscal Year: 2002..Abstract) Neuromuscular synapses form as a result of inductive interactions between motor neurons and muscle fibers. Following contact with the growth cone of a developing motor neuron, developing muscle fibers undergo a ..
- Spectroscopy of myosin light chain domain dynamicsOsha Roopnarine; Fiscal Year: 2007..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
- Respiratory Muscle Weakness in Chronic InflammationMichael B Reid; Fiscal Year: 2010..TNF depresses contractile function of diaphragm and stimulates oxidant production by diaphragm muscle fibers. The oxidants appear to cause weakness since interventions that limit oxidant activity prevent loss of force...