Genomes and Genes
Summary: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of skeletal muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.
Publications308 found, 100 shown here
- Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cellsGary P Kobinger
Gene Therapy Program, Division of Medical Genetics, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Hum Gene Ther 14:1441-9. 2003..this concept, we selected a mouse model of muscular dystrophy (mdx mice) that undergoes rapid turnover of muscle fibers. In vivo targeting of muscle progenitor cells, notably satellite cells, with a pseudotyped lentiviral vector ..
- The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factorsTrevor N Stitt
Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Mol Cell 14:395-403. 2004....
- Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscleRichard I Sherwood
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 119:543-54. 2004..is thought to occur through the action of myogenic satellite cells located in close association with mature muscle fibers; however, these precursor cells have not been prospectively isolated, and recent studies have suggested that ..
- Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycanGünther A Rezniczek
Max F Perutz Laboratories, Department of Molecular Cell Biology, University of Vienna, A 1030 Vienna, Austria
J Cell Biol 176:965-77. 2007..of plectin isoforms during myotube differentiation and their localization to different compartments of muscle fibers, identifying plectins 1 and 1f as sarcolemma-associated isoforms, whereas plectin 1d localizes exclusively to ..
- Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblastsMaurilio Sampaolesi
Stem Cell Research Institute, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
Science 301:487-92. 2003..The success of this protocol was mainly due to widespread distribution of donor stem cells through the capillary network, a distinct advantage of this strategy over previous approaches...
- Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibersAshok Kumar
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
FASEB J 18:102-13. 2004Dystrophin is a cytoskeletal protein found at the inner surface of skeletal and cardiac muscle fibers. We hypothesize that deficiency of dystrophin increases muscle compliance and causes an aberrant mechanotransduction in muscle fibers...
- Stretch-induced, steady-state force enhancement in single skeletal muscle fibers exceeds the isometric force at optimum fiber lengthDilson E Rassier
Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, 2500, University Dr N W Calgary, AB T2N 1N4, Calgary, Canada
J Biomech 36:1309-16. 2003....
- Homer proteins and InsP(3) receptors co-localise in the longitudinal sarcoplasmic reticulum of skeletal muscle fibresM Salanova
Department of Neuroscience, University of Siena, Siena, Italy
Cell Calcium 32:193-200. 2002..Thus, in skeletal muscle, Homer proteins may play a role in the organisation of a second Ca(2+) signalling compartment containing the InsP(3)R, but are apparently not involved in the organisation of RyRs at triads...
- Skeletal muscle repair by adult human mesenchymal stem cells from synovial membraneCosimo De Bari
Laboratory for Skeletal Development and Joint Disorders, Dept of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
J Cell Biol 160:909-18. 2003..When administered into dystrophic muscles of immunosuppressed mdx mice, hSM-MSCs restored sarcolemmal expression of dystrophin, reduced central nucleation, and rescued the expression of mouse mechano growth factor...
- A muscleblind knockout model for myotonic dystrophyRahul N Kanadia
Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, Gainesville, FL 32610, USA
Science 302:1978-80. 2003..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA...
- Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoasMarco Linari
Laboratorio di Fisiologia, Dipartimento di Biologia Animale e Genetica, Universita degli Studi di Firenze, Firenze, Italy
Biophys J 92:2476-90. 2007..The finding that the fraction of myosin heads attached to actin in an isometric contraction is 0.33 rules out the hypothesis of multiple mechanical cycles per ATP hydrolyzed...
- Cholesterol and lipid microdomains stabilize the postsynapse at the neuromuscular junctionRaffaella Willmann
Department of Neurochemistry, Brain Research Institute, University of Zurich, Zurich, Switzerland
EMBO J 25:4050-60. 2006....
- Normal myoblast fusion requires myoferlinKatherine R Doherty
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
Development 132:5565-75. 2005..These data support a role for myoferlin in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes...
- The adaptive potential of skeletal muscle fibersDirk Pette
Department of Biology, University of Konstanz, Germany
Can J Appl Physiol 27:423-48. 2002Mammalian skeletal muscle fibers display a great adaptive potential...
- Relationship between force and stiffness in muscle fibers after stretchDilson E Rassier
Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 Univ Dr, Calgary, AB, Canada T2N 1N4
J Appl Physiol (1985) 99:1769-75. 2005..Because BDM places cross bridges in a weakly bound, pre-powerstroke state, our results further suggest that force enhancement is partially associated with a recruitment of weakly bound cross bridges into a strongly bound state...
- Impaired regeneration of dystrophin-deficient muscle fibers is caused by exhaustion of myogenic cellsM A M Luz
Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil
Braz J Med Biol Res 35:691-5. 2002Duchenne muscular dystrophy is one of the most devastating myopathies. Muscle fibers undergo necrosis and lose their ability to regenerate, and this may be related to increased interstitial fibrosis or the exhaustion of satellite cells...
- C-Met expression and mechanical activation of satellite cells on cultured muscle fibersAshley C Wozniak
Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada
J Histochem Cytochem 51:1437-45. 2003..These methods have a strong potential to further dissect the nature of stretch-induced activation and gene expression among characterized populations of individual quiescent and activated satellite cells...
- Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sandNina Raben
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
Autophagy 3:546-52. 2007..of the human disease, we have analyzed vesicles of the lysosomal-degradative pathway in isolated single muscle fibers from Pompe patients...
- Apoptosis in heart and skeletal muscleAndy J Primeau
School of Kinesiology and Health Science, York University, Toronto, Ontario, M3J 1P3
Can J Appl Physiol 27:349-95. 2002..This review discusses the basic cellular mechanisms of apoptosis, as well as the current evidence of this process in cardiac and skeletal muscle. The need for more work in this area is highlighted, particularly in exercise and training...
- Development of the neuromuscular junctionVeit Witzemann
Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
Cell Tissue Res 326:263-71. 2006..Following the production of muscle fibers, clusters of acetylcholine receptors (AChRs) are concentrated in the central regions of the myofibers via a ..
- Cell lineage tracing during Xenopus tail regenerationCesare Gargioli
Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
Development 131:2669-79. 2004..This shows that metaplasia between differentiated cell types does not occur, and that the process of Xenopus tail regeneration is more akin to tissue renewal in mammals than to urodele tail regeneration...
- The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesisIrina M Conboy
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 3:397-409. 2002....
- The role of nitric oxide in muscle fibers with oxidative phosphorylation defectsCelia H Tengan
Department of Neurology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Biochem Biophys Res Commun 359:771-7. 2007..Our results indicate specific roles of NO in compensatory mechanisms of muscle fibers with mitochondrial deficiency and suggest the participation of nNOS in the signaling process of mitochondrial ..
- Structural differentiation of skeletal muscle fibers in the absence of innervation in humansSimona Boncompagni
Interuniversitary Institute of Miology, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
Proc Natl Acad Sci U S A 104:19339-44. 2007..Most importantly, the recovery occurs in the complete absence of motor and sensory innervation and of nerve-derived trophic factors, that is, solely under the influence of muscle activity induced by electrical stimulation...
- Voltage-dependent dynamic FRET signals from the transverse tubules in mammalian skeletal muscle fibersMarino DiFranco
Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Gen Physiol 130:581-600. 2007..membrane potential changes in the transverse tubular system (TTS) and surface membranes of adult mice skeletal muscle fibers. Farnesylated EGFP or ECFP (EGFP-F and ECFP-F) were used as immobile FRET donors, and either non-fluorescent (..
- Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-kappaBA S Whitehouse
Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
Br J Cancer 89:1116-22. 2003..The results further suggest that EPA may attenuate protein degradation induced by PIF, at least partly, by preventing NF-kappaB accumulation in the nucleus...
- Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophyThea Shavlakadze
School of Anatomy and Human Biology, The University of Western Australia, 35, Stirling Highway, Crawley, Perth, WA 6009, Australia
Neuromuscul Disord 15:139-46. 2005..It is proposed that the protective effect of mIGF-1 on denervated myofibres might be due to reduced protein breakdown...
- IGF-1 induces human myotube hypertrophy by increasing cell recruitmentV Jacquemin
CNRS UMR 7000 Cytosquelette et Développement, Paris, France
Exp Cell Res 299:148-58. 2004..In addition, muscle hypertrophy can be triggered in the absence of proliferation by recruiting more mononucleated cells. We propose that IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle...
- Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophyAmi Mankodi
Department of Neurology, School of Medicine and Dentistry, University of Rochester, Box 673, 601 Elmwood Avenue, New York 14642, USA
Mol Cell 10:35-44. 2002..We propose that a transdominant effect of mutant RNA on RNA processing leads to chloride channelopathy and membrane hyperexcitability in DM...
- Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19Michele R Stone
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 16:4280-93. 2005..Studies in COS-7 cells and in vitro showed that Dys-ABD binds directly and specifically to K19. Expressed in muscle fibers in vivo, K19 accumulated in the myoplasm in structures that contained dystrophin and spectrin and disrupted ..
- Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophySwarnali Acharyya
Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
J Clin Invest 117:889-901. 2007..IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers. Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model ..
- The regenerative plasticity of isolated urodele myofibers and its dependence on MSX1Anoop Kumar
Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
PLoS Biol 2:E218. 2004The conversion of multinucleate postmitotic muscle fibers to dividing mononucleate progeny cells (cellularisation) occurs during limb regeneration in salamanders, but the cellular events and molecular regulation underlying this ..
- Myostatin negatively regulates satellite cell activation and self-renewalSeumas McCroskery
Animal Genomics, AgResearch, Hamilton 2015, New Zealand
J Cell Biol 162:1135-47. 2003..indicates that there is an increased number of satellite cells per unit length of freshly isolated Mstn-/- muscle fibers. Determination of proliferation rate suggests that this elevation in satellite cell number could be due to ..
- Depletion "skraps" and dynamic buffering inside the cellular calcium storeBradley S Launikonis
Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, 1750 West Harrison Street, Suite 1279JS, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 103:2982-7. 2006..When store depletion becomes widespread, the polymers would collapse to increase store [Ca2+] and sustain the concentration gradient that drives release flux...
- Regulation of mitochondrial biogenesis in skeletal muscle by CaMKHai Wu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 296:349-52. 2002..Thus, a calcium-regulated signaling pathway controls mitochondrial biogenesis in mammalian cells...
- Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibersFrançois Xavier Boittin
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
J Cell Sci 119:3733-42. 2006..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
- The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core diseaseGuillermo Avila
Department of Biochemistry, Cinvestav I P N, Zacatenco 07360, Mexico City, Mexico
J Gen Physiol 121:277-86. 2003..These data demonstrate that CCD mutations in exon 102 disrupt release channel permeation to Ca2+ during EC coupling and that this region represents a primary molecular locus for EC uncoupling in CCD...
- Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regenerationKoichi Ojima
Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
Biochem Biophys Res Commun 321:1050-61. 2004..Taken together, our data suggest that neither HSCs nor mature inflammatory cells, but Mac-1(low) early myeloid cells in the BM-derived SP fraction, play an important role in regenerating skeletal muscles...
- Firing rates of motor units during strong dynamic contractionsAlejandro Del Valle
The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Florida 33136, USA
Muscle Nerve 32:316-25. 2005..Thus, protective mechanisms may limit motor unit firing rates during forceful lengthening contractions to minimize damage...
- When contractile proteins go bad: the sarcomere and skeletal muscle diseaseNigel G Laing
Centre for Medical Research, University of Western Australia, West Australian Institute for Medical Research, Nedlands, Western Australia, Australia
Bioessays 27:809-22. 2005..The affected patients and families hope for help sooner rather than later. The onus is on all scientists researching sarcomeric proteins to help develop treatments...
- Functional improvement of dystrophic muscle by myostatin blockadeSasha Bogdanovich
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Richards A 601, Philadelphia, Pennsylvania 19104 6085, USA
Nature 420:418-21. 2002....
- Inhibition of myostatin in adult mice increases skeletal muscle mass and strengthLisa Anne Whittemore
Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Biochem Biophys Res Commun 300:965-71. 2003..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
- Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regenerationAnna Polesskaya
Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
Cell 113:841-52. 2003..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
- Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibersEwa Prochniewicz
Department of Biochemistry, University of Minnesota, Jackson Hall 6 155, 321 Church St, Minneapolis, MN 55455, USA
Am J Physiol Cell Physiol 294:C613-26. 2008..of muscle contractility, we have studied the effects of hydrogen peroxide on permeabilized rabbit psoas muscle fibers, focusing on changes in myosin purified from these fibers...
- Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophyAshok Kumar
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
FASEB J 17:386-96. 2003..Our results show that mechanical stretch activates the classical NF-kappaB pathway and this pathway could be predominately active in DMD...
- Intracellular acidosis enhances the excitability of working muscleThomas H Pedersen
Department of Physiology, University of Aarhus, DK 8000, Denmark
Science 305:1144-7. 2004..These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue...
- Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null miceMarco A P Brotto
Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Cell Res 14:373-8. 2004..we investigated the properties of Ca2+-uptake and -release in toxin-skinned Extensor Digitorium Longus (EDL) muscle fibers from control and mg29 knockout mice...
- Induction of cachexia in mice by systemically administered myostatinTeresa A Zimmers
Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Science 296:1486-8. 2002..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...
- Relationship between utrophin and regenerating muscle fibers in duchenne muscular dystrophyJeong Yun Shim
Department of Pathology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
Yonsei Med J 44:15-23. 2003..These results show that utrophin up-regulation is regeneration-associated, and that it is proportional to the quantity of regenerating myofibers, but is not specific for DMD...
- Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibersEntela Bua
Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
Am J Hum Genet 79:469-80. 2006..The number of VL muscle fibers exhibiting mitochondrial electron-transport-system (ETS) abnormalities increased from an estimated 6% at age ..
- Effects of submaximal exercise on adenine nucleotide concentrations in skeletal muscle fibers of horses with polysaccharide storage myopathyErin J Annandale
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
Am J Vet Res 66:839-45. 2005....
- Differential expression of calcineurin and SR Ca2+ handling proteins in equine muscle fibers during early postnatal growthKarin Eizema
Department of Pathobiology, Division of Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 158, NL 3508 TD, Utrecht, The Netherlands
J Histochem Cytochem 55:247-54. 2007..Although equine muscle is already functional at birth, expression patterns of the monitored proteins still show adaptation, depending on the MyHC fiber type...
- Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1Takashi Kimura
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
Hum Mol Genet 14:2189-200. 2005..We suggest that aberrant splicing of RyR1 and SERCA1 mRNAs might contribute to impaired Ca2+ homeostasis in DM1 muscle...
- Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibersMartin Fluck
M E Müller Institute for Biomechanics, Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
Am J Physiol Regul Integr Comp Physiol 284:R792-801. 2003..accumulation of tenascin-C and an increase of fibronectin in the endomysium of a proportion (8 and 15%) of muscle fibers. Large increases of tenascin-C (40-fold) and fibronectin (7-fold) mRNA within 1 day of reloading indicates the ..
- Calcium signaling in isolated skeletal muscle fibers investigated under "Silicone Voltage-Clamp" conditionsClaude Collet
Laboratoire de Physiologie des Elements Excitables, Universite Claude Bernard Lyon 1, UMR CNRS 5123, F69622 Villeurbanne, France
Cell Biochem Biophys 40:225-36. 2004..properties of the plasma membrane and intracellular signals measured with this methodology in mouse skeletal muscle fibers. Focus is given to the potency of this approach to investigate both fundamental aspects of excitation-..
- Endurance training induces muscle-specific changes in mitochondrial function in skinned muscle fibersYan Burelle
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Appl Physiol (1985) 92:2429-38. 2002....
- Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injuryKambiz Mousavi
Department of Cellular and Molecular Medicine, University of Ottawa, Ontario K1H 8M5, Canada
Am J Physiol Cell Physiol 283:C950-9. 2002..NT treatments prevented the axotomy-induced loss of muscle mass in both EDL and SOL and of total number of muscle fibers in EDL but not in SOL...
- Effect of injecting primary myoblasts versus putative muscle-derived stem cells on mass and force generation in mdx miceGunhild M Mueller
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Hum Gene Ther 13:1081-90. 2002..This may, in part, explain the failure of cellular therapy to alter the contractile properties of murine dystrophic muscle...
- ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiationPeggy Lafuste
Institut National de la Santé et de la Recherche Médicale EMI 0011, Faculty of Medicine, Paris XII University, Creteil 94010, France
Mol Biol Cell 16:861-70. 2005..We conclude that both ADAM12 and alpha9beta1 integrin are expressed during postnatal human myogenic differentiation and that their interaction is mainly operative in nascent myotube growth...
- Nitric oxide-dependence of satellite stem cell activation and quiescence on normal skeletal muscle fibersAshley C Wozniak
Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Dev Dyn 236:240-50. 2007..Results have important implications for designing new therapies that target the role of exercise in health, aging, and disease...
- Changes in muscle fiber conduction velocity indicate recruitment of distinct motor unit populationsC J Houtman
Department of Clinical Neurophysiology, Institute of Neurology, University Medical Centre, 6500 HB Nijmegen, The Netherlands
J Appl Physiol 95:1045-54. 2003..It is most likely that the MFCV pattern can be ascribed to the fatiguing of already recruited predominantly type I motor units, followed by the recruitment of fresh, predominantly type II, motor units...
- Inositol-1,4,5-triphosphate receptors mediate activity-induced synaptic Ca2+ signals in muscle fibers and Ca2+ overload in slow-channel syndromeRoberto Zayas
Department of Neuroscience and Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Cell Calcium 41:343-52. 2007..NMJ and discovered that Ca2+ accumulates significantly faster around the NMJ of SCS transgenic dissociated muscle fibers. Additionally, we determined that this process is dependant on the activation, altered kinetics, and movement ..
- In vivo plasmid DNA electroporation resulted in transfection of satellite cells and lasting transgene expression in regenerated muscle fibersBaowei Peng
School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, PR China
Biochem Biophys Res Commun 338:1490-8. 2005..We found that cells with longer gene expression durations were mostly regenerated muscle fibers. In contrast, expression in pre-existing muscle fibers was rather transient...
- Calcium sensitivity of human single muscle fibers following plyometric trainingLaurent Malisoux
Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain la Neuve, Belgium
Med Sci Sports Exerc 38:1901-8. 2006To study the effect of plyometric training on Ca2+ sensitivity and the influence of troponin T (TnT) isoforms on Ca2+ -activation properties in skinned human muscle fibers.
- Assessment of average muscle fiber conduction velocity from surface EMG signals during fatiguing dynamic contractionsDario Farina
Center of Bioengineering, Department of Electronics, Politecnico di Torino, Torino, Italy
IEEE Trans Biomed Eng 51:1383-93. 2004..Ten subjects were investigated during a 4-min cycling task. The method provided reliable assessment of muscle fatigue for these subjects during dynamic contractions...
- Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibersThomas J Hawke
School of Kinesiology and Health Science, York Univ, 4700 Keele St, Toronto ON Canada
Am J Physiol Cell Physiol 293:C1636-44. 2007..Taken together, the present findings support the hypothesis that Xin is expressed within muscle satellite cells during skeletal muscle regeneration and is involved in the regulation of myoblast function...
- Cross-bridge blocker BTS permits direct measurement of SR Ca2+ pump ATP utilization in toadfish swimbladder muscle fibersIain S Young
Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Physiol Cell Physiol 285:C781-7. 2003..Furthermore, we found that BTS also effectively eliminates force generation in bundles of intact swimbladder muscle, suggesting that it will be an important tool for studying integrated SR function during normal motor behavior...
- Effects of shortening on stretch-induced force enhancement in single skeletal muscle fibersDilson E Rassier
Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Drive, N W Calgary AB, T2N 1N4, Canada
J Biomech 37:1305-12. 2004..of this study was to evaluate the effects of shortening on the stretch-induced force enhancement in single muscle fibers, and indirectly test the hypothesis that force enhancement may be associated with the engagement of a passive ..
- Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatinSimona Iezzi
Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 6:673-84. 2004....
- Non-cross-bridge calcium-dependent stiffness in frog muscle fibersM A Bagni
Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, 50134 Florence, Italy
Am J Physiol Cell Physiol 286:C1353-7. 2004..This stiffness increase may help in maintaining the sarcomere length uniformity under conditions of instability...
- Stretch-shortening cycle exercises: an effective training paradigm to enhance power output of human single muscle fibersLaurent Malisoux
Département d Education Physique et de Réadaptation, Faculte de Medecine, Universite Catholique de Louvain, Louvain la Neuve, Belgium
J Appl Physiol 100:771-9. 2006Functional performance of lower limb muscles and contractile properties of chemically skinned single muscle fibers were evaluated before and after 8 wk of maximal effort stretch-shortening cycle (SSC) exercise training...
- Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibersStephen Hollingworth
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Gen Physiol 127:291-307. 2006The properties of Ca(2+) sparks in frog intact skeletal muscle fibers depolarized with 13 mM [K(+)] Ringer's are well described by a computational model with a Ca(2+) source flux of amplitude 2.5 pA (units of current) and duration 4...
- Hypertrophic muscle fibers with fissures in power-lifters; fiber splitting or defect regeneration?Anders Eriksson
Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87, Umea, Sweden
Histochem Cell Biol 126:409-17. 2006Power-lifters have hypertrophic muscle fibers with fissures seen in cross-sections, called as fiber splitting. Whether this phenomenon is due to real splitting or defective regeneration has not been settled...
- Molecular mechanisms and therapeutics of the deficit in specific force in ageing skeletal muscleOsvaldo Delbono
Department of Physiology and Pharmacology, Department of Internal Medicine, Gerontology and Neuroscience Program, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Biogerontology 3:265-70. 2002..The molecular, functional and structural factors supporting this theory and counteracting measures such as insulin-like growth factor 1 transgenic overexpression are discussed...
- Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injuryMark A Labarge
Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Department of Molecular Pharmacology, Stanford University School of Medicine, CCSR 4215, Stanford, CA 94305, USA
Cell 111:589-601. 2002..signals first induce BMDC to occupy the muscle stem cell niche and then to help regenerate mature muscle fibers. The stress-induced progression of BMDC to muscle satellite cell to muscle fiber results in a contribution to ..
- Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expressionKwok On Lai
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, People s Republic of China
J Biol Chem 279:13383-92. 2004..In addition, the present study provides the first demonstration of a potential function of Eph receptors and Jak/Stat proteins at the NMJ...
- Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifyllineJean François Rolland
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
Neurobiol Dis 24:466-74. 2006..The possibility to pharmacologically counteract abnormal channel activity discloses important therapeutic application...
- Role of protein kinase C and NF-kappaB in proteolysis-inducing factor-induced proteasome expression in C(2)C(12) myotubesH J Smith
Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
Br J Cancer 90:1850-7. 2004..This suggests that PKC may be involved in the phosphorylation and degradation of I-kappaBalpha, induced by PIF, necessary for the release of NF-kappaB from its inactive cytosolic complex...
- Ultrastructure of mouse striated muscle fibers following pravastatin administrationMichael Bergman
Department of Medicine C, Rabin Medical Center, Golda Campus, 7, Keren Kayemet St, Petah Tiqva, Israel
J Muscle Res Cell Motil 24:417-20. 2003..While the ultrastructure of the heart and liver of the treated animals appeared normal, the muscle fibers showed a marked alterations of the mitochondria, which were increased in size compared to those of the ..
- Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeysNolan G Gokey
University of Wisconsin, Department of Animal Health and Biomedical Sciences, Madison, WI 53706, USA
Aging Cell 3:319-26. 2004..deletion mutations co-localize with electron transport system (ETS) abnormalities in rhesus monkey skeletal muscle fibers. Using laser capture microdissection in conjunction with PCR and DNA sequence analysis, mitochondrial genomes ..
- Intracellular PO2 kinetics at different contraction frequencies in Xenopus single skeletal muscle fibersRichard A Howlett
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
J Appl Physiol 102:1456-61. 2007Increasing contraction frequency in single skeletal muscle fibers has been shown to increase the magnitude of the fall in intracellular Po(2) (Pi(O(2))), reflecting a greater metabolic rate...
- Junctional and extrajunctional acetylcholinesterase in skeletal muscle fibersNeva Crne-Finderle
Medical Faculty, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 157:23-7. 2005..Calcineurin signalling pathway seems to be involved...
- BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injuryKambiz Mousavi
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Am J Physiol Cell Physiol 287:C22-9. 2004..known to result in an extensive loss of lumbar motor neurons as well as the disappearance of their respective muscle fibers in the hindlimb musculature...
- Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organizationStephane Dedieu
Laboratoire Biosciences de l Aliment, Universite Bordeaux I, ISTAB USC INRA 429, 33405 Talence Cedex, France
Exp Cell Res 292:187-200. 2004....
- What controls the position, number, size, and distribution of neuromuscular junctions on rat muscle fibers?Terje Lømo
Department of Physiology, University of Oslo, Norway
J Neurocytol 32:835-48. 2003..that determine the position, number, size, and distribution of neuromuscular junctions (NMJs) on skeletal muscle fibers. Most of the data reviewed derive from studies of ectopic NMJ formation on soleus (SOL) muscle fibers in adult ..
- Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory moduleEun Hui Lee
Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Cell Physiol 286:C179-89. 2004..Although we were unable to define the negative module using RyR1-RyR2 chimeras, they further demonstrated that the RyR is very sensitive to long-range allosterism...
- Regulated sarcolemmal localization of the muscle-specific ClC-1 chloride channelH Papponen
Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FIN 90014, Finland
Exp Neurol 191:163-73. 2005..These data indicate that sarcolemmal targeting of the ClC-1 requires specific signals that are provided by the physiological environment...
- Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signalingPatrick Steigemann
Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Goettingen, Germany
Curr Biol 14:225-30. 2004..The results suggest that Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells...
- Muscle satellite cellsJennifer E Morgan
Muscle Cell Biology Group, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Int J Biochem Cell Biol 35:1151-6. 2003..e. approximately 1 x 10(10) to 2 x 10(10) satellite cells per person. (2) Main functions: repair and maintenance of skeletal muscle. (3) Turnover rate: close to zero in non-traumatic conditions-high in disease or severe trauma...
- Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouseElla W Yeung
School of Medical Sciences and Institute for Biomedical Research, University of Sydney F13, NSW 2006, Australia
J Physiol 562:367-80. 2005..This result suggests that blockers of stretch-activated channels may protect against muscle damage in the intact mdx mouse...
- The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathyPhilipp Christoph Janiesch
Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
Nat Cell Biol 9:379-90. 2007....
- Effects of endurance training on satellite cell frequency in skeletal muscle of old menNadia Charifi
Laboratoire de Physiologie, Groupement d Intérêt Public Exercice Sport Santé, Université Saint Etienne, Saint Etienne, France
Muscle Nerve 28:87-92. 2003..The enhancement of satellite cell frequency and fiber area indicate that endurance training is an efficient strategy to improve muscle function in the elderly...
- Histochemical and immunohistochemical study on muscle fibers in human extraocular muscle spindlesWaltraut Wicke
Medical University of Vienna, Center of Anatomy and Cell Biology, Integrative Morphology Group, Waehringer Stasse 13, 1090 Vienna, and Institute of Pathology and Bacteriology, Kaiserin Elisabeth Hospital, Austria
Exp Eye Res 84:670-9. 2007..Aim of this study was to establish a classification of intrafusal muscle fibers of human extraocular muscles based on their histochemical and immunohistochemical properties and to determine ..
- Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibersPietro Fratta
Department of Neurology, USC Neuromuscular Center, Good Samaritan Hospital, Los Angeles, CA 90017 1912, USA
Am J Pathol 167:517-26. 2005..ubiquitinated multiprotein-aggregates are characteristic of sporadic inclusion-body myositis (s-IBM) muscle fibers. Two major types of aggregates exist, containing either amyloid-beta (Abeta) or phosphorylated tau (p-tau)...
- Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old miceJ C Bruusgaard
Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindern NO 0316, Oslo, Norway
J Appl Physiol 100:2024-30. 2006We have recently published a new technique for visualizing nuclei in living muscle fibers of intact animals, based on microinjection of labeled DNA into single myofibers, excluding satellite cells (Bruusgaard JC, Liestol K, Ekmark M, ..
- Design and function of superfast muscles: new insights into the physiology of skeletal muscleLawrence C Rome
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Annu Rev Physiol 68:193-221. 2006..Hence the locomotory and sound-producing muscles have mutually exclusive designs...
- Effects of running exercise during recovery from hindlimb unloading on soleus muscle fibers and their spinal motoneurons in ratsAkihiko Ishihara
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Neurosci Res 48:119-27. 2004..unloading and recovery with or without running exercise on morphological and metabolic properties of soleus muscle fibers and their spinal motoneurons in rats were investigated...
- Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetesMads K Holten
Department of Medical Physiology, The Panum Institute, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Diabetes 53:294-305. 2004..The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade...
- Therapeutic clenbuterol treatment does not alter Ca2+ sensitivity of permeabilized fast muscle fibres from exercise trained or untrained horsesDavid R Plant
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
J Muscle Res Cell Motil 24:471-6. 2003..The results indicate that a therapeutic dose of clenbuterol to Standardbred horses does not affect the Ca(2+)-activated contractile characteristics of isolated muscle fibres...
- Regulation of muscle fiber type and running endurance by PPARdeltaYong Xu Wang
Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
PLoS Biol 2:e294. 2004..receptor delta (PPARdelta) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers. Treatment of wild-type mice with PPARdelta agonist elicits a similar type I fiber gene expression profile in ..
- Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiationMichael S Huh
Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, K1H 8L6
J Cell Biol 166:865-76. 2004..Therefore, Rb plays a crucial role in the switch from proliferation to differentiation rather than maintenance of the terminally differentiated state...
- Bioengineering Core for Cellular and Tissue ModelsAndrew McCulloch; Fiscal Year: 2009..between titin epitopes and the z-disk were determined using FFT analysis as we reported earlier for skeletal muscle fibers (Shah et al., 2004). 219 Knowlton, Kirk U. C3.3. Isolated Perfused Whole Mouse Heart Preparations C3.3.a...
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2003..multiple nerves, each of which supplies a distinct region within the muscle, and that it contains specialized muscle fibers. One of these, slow tonic muscle fibers (STMF) has a unique physiology...
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2002..multiple nerves, each of which supplies a distinct region within the muscle, and that it contains specialized muscle fibers. One of these, slow tonic muscle fibers (STMF) has a unique physiology...
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2004..multiple nerves, each of which supplies a distinct region within the muscle, and that it contains specialized muscle fibers. One of these, slow tonic muscle fibers (STMF) has a unique physiology...
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2003..by staining to show details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor ..
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2001..by staining to show details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor ..
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2002..by staining to show details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor ..
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2003
- The Anatomical Basis of Human Tongue BiomechanicsIra Sanders; Fiscal Year: 2001
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2001
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2003
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJulio L Vergara; Fiscal Year: 2010..This functional characterization will be achieved in muscle fibers from various animal models of human muscular dystrophies...
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJULIO VERGARA; Fiscal Year: 2009..This functional characterization will be achieved in muscle fibers from various animal models of human muscular dystrophies...
- Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC MutationsJulian Borejdo; Fiscal Year: 2009..We will examine this hypothesis at the single molecule level in papillary muscle fibers from transgenic mouse hearts which carry disease-causing mutations in the regulatory and/or essential light ..
- Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC MutationsDanuta Szczesna Cordary; Fiscal Year: 2010..We will examine this hypothesis at the single molecule level in papillary muscle fibers from transgenic mouse hearts which carry disease-causing mutations in the regulatory and/or essential light ..
- MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZEPaul May; Fiscal Year: 2009..motor neurons that control the lens and pupil, and the motor neurons that control the multiply innervated muscle fibers (MIFs) in the extraocular muscles. MIFs are highly fatigue resistant and tonically active...
- Synaptic target selection in DrosophilaKai Zinn; Fiscal Year: 2009..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...
- MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZEPaul J May; Fiscal Year: 2010..motor neurons that control the lens and pupil, and the motor neurons that control the multiply innervated muscle fibers (MIFs) in the extraocular muscles. MIFs are highly fatigue resistant and tonically active...
- Role of Type I Interferons in a Self-Sustaining Murine Model of MyositisThomas Griffin; Fiscal Year: 2007..excessive expression of MHC class I molecules and an associated unfolded protein response (UPR) in affected muscle fibers in each of these conditions suggests a common mechanism for chronic muscle fiber injury...
- Pbx Homeodomain Proteins in Skeletal Muscle DifferentiationLISA A MAVES; Fiscal Year: 2010PROJECT SUMMARY The differentiation of muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular ..
- Pbx Homeodomain Proteins in Skeletal Muscle DifferentiationLisa Maves; Fiscal Year: 2009PROJECT SUMMARY The differentiation of muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular ..
- MICROMECHANICS OF RESPIRATORY MUSCLESALADIN BORIEK; Fiscal Year: 1999..hypothesize that the costal diaphragm has an in-series fiber architecture, and tension is transmitted between muscle fibers along their lateral surfaces through the connective tissue...
- EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCEMichael Lewis; Fiscal Year: 1992..disease (COPD) resulting in altered diaphragmatic strength and endurance, due to atrophy of fast- twitch muscle fibers corticosteroids, which are often used in COPD, also causes as well as a decrease in the oxidative capacity of ..
- EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCEMichael Lewis; Fiscal Year: 1990..disease (COPD) resulting in altered diaphragmatic strength and endurance, due to atrophy of fast- twitch muscle fibers corticosteroids, which are often used in COPD, also causes as well as a decrease in the oxidative capacity of ..
- Role of Troponin T Isoforms in Amish Nemaline MyopathyJian Ping Jin; Fiscal Year: 2007..are neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers Recent studies have identified a recessively inherited form of nemaline myopathy, the Amish nemaline myopathy (..
- DIAPHRAGM FATIGUEGary Sieck; Fiscal Year: 1990..b>Muscle fibers will be classified as Type I, IIA or IIB based on differences in staining for myosin ATPase at different ..
- DIAPHRAGM FATIGUEGary Sieck; Fiscal Year: 1991..b>Muscle fibers will be classified as Type I, IIA or IIB based on differences in staining for myosin ATPase at different ..
- FROM CARDIAC MUSCLE TO VENTRICLEWilliam Hunter; Fiscal Year: 1990..This project continues the theme of relating the behavior of the whole left ventricle to its constituent cardiac muscle fibers. Two distinct topics have been targeted...
- MECHANISMS OF MYOGENIC INDUCTION AND PATTERN IN SOMITESFrank Stockdale; Fiscal Year: 1999..induce myogenesis in explanted unspecified somites (somites which when cultured alone do not form muscle fibers)...
- ALPHA 7 BETA1 INTEGRIN AND MUSCLE INTEGRITYStephen Kaufman; Fiscal Year: 2000DESCRIPTION (adapted from investigator's abstract): The proper association of muscle fibers with their extracellular matrix is essential to the normal functioning of skeletal muscle...
- ALPHA 7 BETA1 INTEGRIN AND MUSCLE INTEGRITYStephen Kaufman; Fiscal Year: 1999DESCRIPTION (adapted from investigator's abstract): The proper association of muscle fibers with their extracellular matrix is essential to the normal functioning of skeletal muscle...
- FAILURE OF THE CONTRACTILE PROCESS IN FATIGUEThomas Nosek; Fiscal Year: 1993Fast, glycolytic muscle fibers are typically subjected to stimulation of short duration and high intensity. In response, force reversibly declines; i.e. the fibers fatigue...
- Role of ERK1/2 in Neuromuscular Synapses and Myofiber Development in vivoMendell Rimer; Fiscal Year: 2012..However, no gene targeting investigations on the role of ERK1/2 in developing muscle fibers in vivo have been reported to date...
- Role of actin domains in force generation in myocardiumMasataka Kawai; Fiscal Year: 2010..Our research involves selectively removing the thin filament from cardiac muscle fibers (myocardium) by gelsolin treatment, and sequentially reconstituting the thin filament with G-actin and the ..
- Role of actin domains in force generation in myocardiumMasataka Kawai; Fiscal Year: 2009..Our research involves selectively removing the thin filament from cardiac muscle fibers (myocardium) by gelsolin treatment, and sequentially reconstituting the thin filament with G-actin and the ..
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2006..Another important finding was that the adult pharyngeal muscles contained muscle fibers expressing unusual myosin heavy chain (MHC) isoforms (slow-tonic and alpha-cardiac) which were concentrated ..
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2007..Another important finding was that the adult pharyngeal muscles contained muscle fibers expressing unusual myosin heavy chain (MHC) isoforms (slow-tonic and alpha-cardiac) which were concentrated ..
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2005..Another important finding was that the adult pharyngeal muscles contained muscle fibers expressing unusual myosin heavy chain (MHC) isoforms (slow-tonic and alpha-cardiac) which were concentrated ..
- Impact of Exercise on SarcopeniaJudd Aiken; Fiscal Year: 2009..We have shown that age-dependent mtDNA deletion mutations clonally accumulate to high levels in aged skeletal muscle fibers. Concomitant with this increase in aberrant genomes is a loss of complex IV (cytochrome c oxidase;COX-) ..
- Impact of Exercise on SarcopeniaJudd M Aiken; Fiscal Year: 2010..We have shown that age-dependent mtDNA deletion mutations clonally accumulate to high levels in aged skeletal muscle fibers. Concomitant with this increase in aberrant genomes is a loss of complex IV (cytochrome c oxidase;COX-) ..
- MYOBLAST GROWTH AND DIFFERENTIATION DURING MUSCLE AGINGCharlotte Peterson; Fiscal Year: 1999..myoblasts that proliferate and differentiate in response to muscle degeneration thereby regenerating damaged muscle fibers. Muscle regeneration is impaired in aged individuals...
- MYOBLAST GROWTH AND DIFFERENTIATION DURING MUSCLE AGINGCharlotte Peterson; Fiscal Year: 2000..myoblasts that proliferate and differentiate in response to muscle degeneration thereby regenerating damaged muscle fibers. Muscle regeneration is impaired in aged individuals...
- DEVELOPMENTAL AGE AND CHANGES IN MYOSIN ISOZYMESFrank Stockdale; Fiscal Year: 1990..Myosin heavy chain is both a structural and a functional (enzyme) protein within the sarcomeres of developing muscle fibers. Expression of multiple isoforms of the myosin heavy chain family within developing muscle fibers is regulated ..
- MECHANISM OF CARDIAC MUSCLE REGULATION BY TROPONINJames Potter; Fiscal Year: 1990..being addressed deal with determining the state of the single Ca2+ regulatory site on cardiac TnC in skinned muscle fibers and how it is modulated by various physiological and pathological states of the heart...
- Spectroscopy of myosin light chain domain dynamicsOsha Roopnarine; Fiscal Year: 2007..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
- Spectroscopy of myosin light chain domain dynamicsOsha Roopnarine; Fiscal Year: 2006..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
- Spectroscopy of myosin light chain domain dynamicsOsha Roopnarine; Fiscal Year: 2010..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
- SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTORSTEVEN BURDEN; Fiscal Year: 1999..Abstract) Neuromuscular synapses form as a result of inductive interactions between motor neurons and muscle fibers. Following contact with the growth cone of a developing motor neuron, developing muscle fibers undergo a ..
- SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTORSTEVEN BURDEN; Fiscal Year: 2000..Abstract) Neuromuscular synapses form as a result of inductive interactions between motor neurons and muscle fibers. Following contact with the growth cone of a developing motor neuron, developing muscle fibers undergo a ..
- SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTORSTEVEN BURDEN; Fiscal Year: 2001..Abstract) Neuromuscular synapses form as a result of inductive interactions between motor neurons and muscle fibers. Following contact with the growth cone of a developing motor neuron, developing muscle fibers undergo a ..
- Spectroscopy of myosin light chain domain dynamicsOsha Roopnarine; Fiscal Year: 2009
- SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTORSTEVEN BURDEN; Fiscal Year: 2002
- ELECTRICAL AND CONTRACTILE PROPERTIES OF MUSCLEWilliam Chandler; Fiscal Year: 1999In vertebrate twitch muscle fibers, contraction is normally activated by a depolarization of the membranes of the transverse tubular system...
- Preclinical Trials of NFkappaB Inhibition in the Treatment of Muscular DystrophyC Carlson; Fiscal Year: 2009..nuclear factor-kappaB (NFkB) have distinct beneficial effects in substantially reducing the loss of striated muscle fibers and restoring the resting membrane potential in severely dystrophic (mdx) muscle fibers ...
- Protein Therapeutics for Muscular DystrophyNorio Takizawa; Fiscal Year: 2010..data to show that intra-muscular delivery of recombinant MG53 can ameliorate cardiotoxin-induced damage to the muscle fibers. This project will comprise an effort by TRIM-edicine that will leverage our expertise to pursue the proof-of-..
- Respiratory Muscle Weakness in Chronic InflammationMichael B Reid; Fiscal Year: 2010..TNF depresses contractile function of diaphragm and stimulates oxidant production by diaphragm muscle fibers. The oxidants appear to cause weakness since interventions that limit oxidant activity prevent loss of force...
- Respiratory Muscle Weakness in Chronic InflammationMichael Reid; Fiscal Year: 2009..TNF depresses contractile function of diaphragm and stimulates oxidant production by diaphragm muscle fibers. The oxidants appear to cause weakness since interventions that limit oxidant activity prevent loss of force...
- POSTEMBRYONIC DEVELOPMENT OF LEG MOTOR CIRCUITSRichard Levine; Fiscal Year: 2000..Motoneurons regulate the differentiation of muscle fibers and retrograde signals from the muscle fibers may be essential for the presynaptic specialization of motor ..
- POSTEMBRYONIC DEVELOPMENT OF LEG MOTOR CIRCUITSRichard Levine; Fiscal Year: 1999..Motoneurons regulate the differentiation of muscle fibers and retrograde signals from the muscle fibers may be essential for the presynaptic specialization of motor ..
- Synaptic target selection in DrosophilaKAI G ZINN; Fiscal Year: 2010..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...
- SKELETAL MUSCLE MICROVASCULAR PERFUSION IN HYPERTENSIONSarah Gray; Fiscal Year: 1999DESCRIPTION: Restoration of muscle function after injury requires the coordinate restoration of muscle fibers and microcirculation, as well as muscle and vascular innervation...
- CA2+ REGULATION OF MUSCLE CONTRACTIONJames Potter; Fiscal Year: 1992..These include reconstituted thin filaments, TnC depleted reconstituted skinned fibers and intact muscle fibers. These systems combined with the techniques of fluorescence spectroscopy, flash photolysis of caged compounds, ..
- FUNCTIONAL AND MOLECULAR STUDY OF HUMAN MASSETER FIBERSJames Sciote; Fiscal Year: 1999DESCRIPTION (Adapted from the Applicant's Abstract): Mammalian skeletal muscle fibers have been traditionally classified into specific types by characterization of their myofibrillar ATPase and metabolic histochemistry and more recently ..
- CELL LINEAGE COMMITMENT IN MAMMALIAN MYOGENESISJeffrey Miller; Fiscal Year: 1990..Cells first become committed to myogenesis and form muscle fibers in the somites...
- FUNCTIONAL AND MOLECULAR STUDY OF HUMAN MASSETER FIBERSJames Sciote; Fiscal Year: 2000DESCRIPTION (Adapted from the Applicant's Abstract): Mammalian skeletal muscle fibers have been traditionally classified into specific types by characterization of their myofibrillar ATPase and metabolic histochemistry and more recently ..
- Role of RyRs, DHPRs and Ca2+ Entry in the Inclusion Body MyositisAlexander Shtifman; Fiscal Year: 2009..He has also demonstrated that chronically elevated levels of 2- amyloid in the muscle fibers from the transgenic mouse models of IBM also exhibit a substantially elevated myoplasmic [Ca2+]i...
- LONG MUSCLES WITH SERIES FIBERS--ULTASTRUCTUREJohn Trotter; Fiscal Year: 1990..with parallel architecture such as the hamstrings, sartorius, adductors and abdominal muscles, the individual muscle fibers are shorter than the muscle, and terminate within the muscle by tapering to fine endings...