muscle fibers

Summary

Summary: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of skeletal muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.

Top Publications

  1. ncbi Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells
    Gary P Kobinger
    Gene Therapy Program, Division of Medical Genetics, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Hum Gene Ther 14:1441-9. 2003
  2. ncbi The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
  3. ncbi Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
  4. pmc Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan
    Günther A Rezniczek
    Max F Perutz Laboratories, Department of Molecular Cell Biology, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 176:965-77. 2007
  5. ncbi Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts
    Maurilio Sampaolesi
    Stem Cell Research Institute, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Science 301:487-92. 2003
  6. ncbi Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers
    Ashok Kumar
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:102-13. 2004
  7. ncbi Stretch-induced, steady-state force enhancement in single skeletal muscle fibers exceeds the isometric force at optimum fiber length
    Dilson E Rassier
    Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, 2500, University Dr N W Calgary, AB T2N 1N4, Calgary, Canada
    J Biomech 36:1309-16. 2003
  8. ncbi Homer proteins and InsP(3) receptors co-localise in the longitudinal sarcoplasmic reticulum of skeletal muscle fibres
    M Salanova
    Department of Neuroscience, University of Siena, Siena, Italy
    Cell Calcium 32:193-200. 2002
  9. pmc Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane
    Cosimo De Bari
    Laboratory for Skeletal Development and Joint Disorders, Dept of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Cell Biol 160:909-18. 2003
  10. ncbi A muscleblind knockout model for myotonic dystrophy
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, Gainesville, FL 32610, USA
    Science 302:1978-80. 2003

Detail Information

Publications308 found, 100 shown here

  1. ncbi Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells
    Gary P Kobinger
    Gene Therapy Program, Division of Medical Genetics, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Hum Gene Ther 14:1441-9. 2003
    ..this concept, we selected a mouse model of muscular dystrophy (mdx mice) that undergoes rapid turnover of muscle fibers. In vivo targeting of muscle progenitor cells, notably satellite cells, with a pseudotyped lentiviral vector ..
  2. ncbi The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
    ....
  3. ncbi Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle
    Richard I Sherwood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 119:543-54. 2004
    ..is thought to occur through the action of myogenic satellite cells located in close association with mature muscle fibers; however, these precursor cells have not been prospectively isolated, and recent studies have suggested that ..
  4. pmc Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan
    Günther A Rezniczek
    Max F Perutz Laboratories, Department of Molecular Cell Biology, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 176:965-77. 2007
    ..of plectin isoforms during myotube differentiation and their localization to different compartments of muscle fibers, identifying plectins 1 and 1f as sarcolemma-associated isoforms, whereas plectin 1d localizes exclusively to ..
  5. ncbi Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts
    Maurilio Sampaolesi
    Stem Cell Research Institute, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Science 301:487-92. 2003
    ..The success of this protocol was mainly due to widespread distribution of donor stem cells through the capillary network, a distinct advantage of this strategy over previous approaches...
  6. ncbi Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers
    Ashok Kumar
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:102-13. 2004
    Dystrophin is a cytoskeletal protein found at the inner surface of skeletal and cardiac muscle fibers. We hypothesize that deficiency of dystrophin increases muscle compliance and causes an aberrant mechanotransduction in muscle fibers...
  7. ncbi Stretch-induced, steady-state force enhancement in single skeletal muscle fibers exceeds the isometric force at optimum fiber length
    Dilson E Rassier
    Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, 2500, University Dr N W Calgary, AB T2N 1N4, Calgary, Canada
    J Biomech 36:1309-16. 2003
    ....
  8. ncbi Homer proteins and InsP(3) receptors co-localise in the longitudinal sarcoplasmic reticulum of skeletal muscle fibres
    M Salanova
    Department of Neuroscience, University of Siena, Siena, Italy
    Cell Calcium 32:193-200. 2002
    ..Thus, in skeletal muscle, Homer proteins may play a role in the organisation of a second Ca(2+) signalling compartment containing the InsP(3)R, but are apparently not involved in the organisation of RyRs at triads...
  9. pmc Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane
    Cosimo De Bari
    Laboratory for Skeletal Development and Joint Disorders, Dept of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Cell Biol 160:909-18. 2003
    ..When administered into dystrophic muscles of immunosuppressed mdx mice, hSM-MSCs restored sarcolemmal expression of dystrophin, reduced central nucleation, and rescued the expression of mouse mechano growth factor...
  10. ncbi A muscleblind knockout model for myotonic dystrophy
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, Gainesville, FL 32610, USA
    Science 302:1978-80. 2003
    ..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA...
  11. pmc Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoas
    Marco Linari
    Laboratorio di Fisiologia, Dipartimento di Biologia Animale e Genetica, Universita degli Studi di Firenze, Firenze, Italy
    Biophys J 92:2476-90. 2007
    ..The finding that the fraction of myosin heads attached to actin in an isometric contraction is 0.33 rules out the hypothesis of multiple mechanical cycles per ATP hydrolyzed...
  12. pmc Cholesterol and lipid microdomains stabilize the postsynapse at the neuromuscular junction
    Raffaella Willmann
    Department of Neurochemistry, Brain Research Institute, University of Zurich, Zurich, Switzerland
    EMBO J 25:4050-60. 2006
    ....
  13. ncbi Normal myoblast fusion requires myoferlin
    Katherine R Doherty
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 132:5565-75. 2005
    ..These data support a role for myoferlin in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes...
  14. ncbi The adaptive potential of skeletal muscle fibers
    Dirk Pette
    Department of Biology, University of Konstanz, Germany
    Can J Appl Physiol 27:423-48. 2002
    Mammalian skeletal muscle fibers display a great adaptive potential...
  15. ncbi Relationship between force and stiffness in muscle fibers after stretch
    Dilson E Rassier
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 Univ Dr, Calgary, AB, Canada T2N 1N4
    J Appl Physiol (1985) 99:1769-75. 2005
    ..Because BDM places cross bridges in a weakly bound, pre-powerstroke state, our results further suggest that force enhancement is partially associated with a recruitment of weakly bound cross bridges into a strongly bound state...
  16. ncbi Impaired regeneration of dystrophin-deficient muscle fibers is caused by exhaustion of myogenic cells
    M A M Luz
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil
    Braz J Med Biol Res 35:691-5. 2002
    Duchenne muscular dystrophy is one of the most devastating myopathies. Muscle fibers undergo necrosis and lose their ability to regenerate, and this may be related to increased interstitial fibrosis or the exhaustion of satellite cells...
  17. ncbi C-Met expression and mechanical activation of satellite cells on cultured muscle fibers
    Ashley C Wozniak
    Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada
    J Histochem Cytochem 51:1437-45. 2003
    ..These methods have a strong potential to further dissect the nature of stretch-induced activation and gene expression among characterized populations of individual quiescent and activated satellite cells...
  18. ncbi Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand
    Nina Raben
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Autophagy 3:546-52. 2007
    ..of the human disease, we have analyzed vesicles of the lysosomal-degradative pathway in isolated single muscle fibers from Pompe patients...
  19. ncbi Apoptosis in heart and skeletal muscle
    Andy J Primeau
    School of Kinesiology and Health Science, York University, Toronto, Ontario, M3J 1P3
    Can J Appl Physiol 27:349-95. 2002
    ..This review discusses the basic cellular mechanisms of apoptosis, as well as the current evidence of this process in cardiac and skeletal muscle. The need for more work in this area is highlighted, particularly in exercise and training...
  20. ncbi Development of the neuromuscular junction
    Veit Witzemann
    Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Cell Tissue Res 326:263-71. 2006
    ..Following the production of muscle fibers, clusters of acetylcholine receptors (AChRs) are concentrated in the central regions of the myofibers via a ..
  21. ncbi Cell lineage tracing during Xenopus tail regeneration
    Cesare Gargioli
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 131:2669-79. 2004
    ..This shows that metaplasia between differentiated cell types does not occur, and that the process of Xenopus tail regeneration is more akin to tissue renewal in mammals than to urodele tail regeneration...
  22. ncbi The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
    ....
  23. ncbi The role of nitric oxide in muscle fibers with oxidative phosphorylation defects
    Celia H Tengan
    Department of Neurology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Biochem Biophys Res Commun 359:771-7. 2007
    ..Our results indicate specific roles of NO in compensatory mechanisms of muscle fibers with mitochondrial deficiency and suggest the participation of nNOS in the signaling process of mitochondrial ..
  24. pmc Structural differentiation of skeletal muscle fibers in the absence of innervation in humans
    Simona Boncompagni
    Interuniversitary Institute of Miology, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
    Proc Natl Acad Sci U S A 104:19339-44. 2007
    ..Most importantly, the recovery occurs in the complete absence of motor and sensory innervation and of nerve-derived trophic factors, that is, solely under the influence of muscle activity induced by electrical stimulation...
  25. pmc Voltage-dependent dynamic FRET signals from the transverse tubules in mammalian skeletal muscle fibers
    Marino DiFranco
    Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Gen Physiol 130:581-600. 2007
    ..membrane potential changes in the transverse tubular system (TTS) and surface membranes of adult mice skeletal muscle fibers. Farnesylated EGFP or ECFP (EGFP-F and ECFP-F) were used as immobile FRET donors, and either non-fluorescent (..
  26. pmc Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-kappaB
    A S Whitehouse
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Cancer 89:1116-22. 2003
    ..The results further suggest that EPA may attenuate protein degradation induced by PIF, at least partly, by preventing NF-kappaB accumulation in the nucleus...
  27. ncbi Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy
    Thea Shavlakadze
    School of Anatomy and Human Biology, The University of Western Australia, 35, Stirling Highway, Crawley, Perth, WA 6009, Australia
    Neuromuscul Disord 15:139-46. 2005
    ..It is proposed that the protective effect of mIGF-1 on denervated myofibres might be due to reduced protein breakdown...
  28. ncbi IGF-1 induces human myotube hypertrophy by increasing cell recruitment
    V Jacquemin
    CNRS UMR 7000 Cytosquelette et Développement, Paris, France
    Exp Cell Res 299:148-58. 2004
    ..In addition, muscle hypertrophy can be triggered in the absence of proliferation by recruiting more mononucleated cells. We propose that IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle...
  29. ncbi Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy
    Ami Mankodi
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Box 673, 601 Elmwood Avenue, New York 14642, USA
    Mol Cell 10:35-44. 2002
    ..We propose that a transdominant effect of mutant RNA on RNA processing leads to chloride channelopathy and membrane hyperexcitability in DM...
  30. pmc Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19
    Michele R Stone
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 16:4280-93. 2005
    ..Studies in COS-7 cells and in vitro showed that Dys-ABD binds directly and specifically to K19. Expressed in muscle fibers in vivo, K19 accumulated in the myoplasm in structures that contained dystrophin and spectrin and disrupted ..
  31. pmc Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Clin Invest 117:889-901. 2007
    ..IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling is persistently elevated in immune cells and regenerative muscle fibers. Ablation of 1 allele of the p65 subunit of NF-kappaB was sufficient to improve pathology in mdx mice, a model ..
  32. pmc The regenerative plasticity of isolated urodele myofibers and its dependence on MSX1
    Anoop Kumar
    Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom
    PLoS Biol 2:E218. 2004
    The conversion of multinucleate postmitotic muscle fibers to dividing mononucleate progeny cells (cellularisation) occurs during limb regeneration in salamanders, but the cellular events and molecular regulation underlying this ..
  33. pmc Myostatin negatively regulates satellite cell activation and self-renewal
    Seumas McCroskery
    Animal Genomics, AgResearch, Hamilton 2015, New Zealand
    J Cell Biol 162:1135-47. 2003
    ..indicates that there is an increased number of satellite cells per unit length of freshly isolated Mstn-/- muscle fibers. Determination of proliferation rate suggests that this elevation in satellite cell number could be due to ..
  34. pmc Depletion "skraps" and dynamic buffering inside the cellular calcium store
    Bradley S Launikonis
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, 1750 West Harrison Street, Suite 1279JS, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:2982-7. 2006
    ..When store depletion becomes widespread, the polymers would collapse to increase store [Ca2+] and sustain the concentration gradient that drives release flux...
  35. ncbi Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
    Hai Wu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 296:349-52. 2002
    ..Thus, a calcium-regulated signaling pathway controls mitochondrial biogenesis in mammalian cells...
  36. ncbi Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers
    François Xavier Boittin
    Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
    J Cell Sci 119:3733-42. 2006
    ..The Ca2+-independent phospholipase A2 pathway therefore appears as an attractive target to reduce excessive Ca2+ influx and subsequent degeneration occurring in dystrophic fibers...
  37. pmc The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease
    Guillermo Avila
    Department of Biochemistry, Cinvestav I P N, Zacatenco 07360, Mexico City, Mexico
    J Gen Physiol 121:277-86. 2003
    ..These data demonstrate that CCD mutations in exon 102 disrupt release channel permeation to Ca2+ during EC coupling and that this region represents a primary molecular locus for EC uncoupling in CCD...
  38. ncbi Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regeneration
    Koichi Ojima
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 321:1050-61. 2004
    ..Taken together, our data suggest that neither HSCs nor mature inflammatory cells, but Mac-1(low) early myeloid cells in the BM-derived SP fraction, play an important role in regenerating skeletal muscles...
  39. ncbi Firing rates of motor units during strong dynamic contractions
    Alejandro Del Valle
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Florida 33136, USA
    Muscle Nerve 32:316-25. 2005
    ..Thus, protective mechanisms may limit motor unit firing rates during forceful lengthening contractions to minimize damage...
  40. ncbi When contractile proteins go bad: the sarcomere and skeletal muscle disease
    Nigel G Laing
    Centre for Medical Research, University of Western Australia, West Australian Institute for Medical Research, Nedlands, Western Australia, Australia
    Bioessays 27:809-22. 2005
    ..The affected patients and families hope for help sooner rather than later. The onus is on all scientists researching sarcomeric proteins to help develop treatments...
  41. ncbi Functional improvement of dystrophic muscle by myostatin blockade
    Sasha Bogdanovich
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Richards A 601, Philadelphia, Pennsylvania 19104 6085, USA
    Nature 420:418-21. 2002
    ....
  42. ncbi Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
    Lisa Anne Whittemore
    Musculoskeletal Sciences Department, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 300:965-71. 2003
    ..These data show for the first time that myostatin acts postnatally as a negative regulator of skeletal muscle growth and suggest that myostatin inhibitors could provide a therapeutic benefit in diseases for which muscle mass is limiting...
  43. ncbi Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration
    Anna Polesskaya
    Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
    Cell 113:841-52. 2003
    ..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
  44. ncbi Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers
    Ewa Prochniewicz
    Department of Biochemistry, University of Minnesota, Jackson Hall 6 155, 321 Church St, Minneapolis, MN 55455, USA
    Am J Physiol Cell Physiol 294:C613-26. 2008
    ..of muscle contractility, we have studied the effects of hydrogen peroxide on permeabilized rabbit psoas muscle fibers, focusing on changes in myosin purified from these fibers...
  45. ncbi Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy
    Ashok Kumar
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 17:386-96. 2003
    ..Our results show that mechanical stretch activates the classical NF-kappaB pathway and this pathway could be predominately active in DMD...
  46. ncbi Intracellular acidosis enhances the excitability of working muscle
    Thomas H Pedersen
    Department of Physiology, University of Aarhus, DK 8000, Denmark
    Science 305:1144-7. 2004
    ..These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue...
  47. ncbi Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice
    Marco A P Brotto
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell Res 14:373-8. 2004
    ..we investigated the properties of Ca2+-uptake and -release in toxin-skinned Extensor Digitorium Longus (EDL) muscle fibers from control and mg29 knockout mice...
  48. ncbi Induction of cachexia in mice by systemically administered myostatin
    Teresa A Zimmers
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 296:1486-8. 2002
    ..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...
  49. ncbi Relationship between utrophin and regenerating muscle fibers in duchenne muscular dystrophy
    Jeong Yun Shim
    Department of Pathology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 44:15-23. 2003
    ..These results show that utrophin up-regulation is regeneration-associated, and that it is proportional to the quantity of regenerating myofibers, but is not specific for DMD...
  50. pmc Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers
    Entela Bua
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Am J Hum Genet 79:469-80. 2006
    ..The number of VL muscle fibers exhibiting mitochondrial electron-transport-system (ETS) abnormalities increased from an estimated 6% at age ..
  51. ncbi Effects of submaximal exercise on adenine nucleotide concentrations in skeletal muscle fibers of horses with polysaccharide storage myopathy
    Erin J Annandale
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    Am J Vet Res 66:839-45. 2005
    ....
  52. ncbi Differential expression of calcineurin and SR Ca2+ handling proteins in equine muscle fibers during early postnatal growth
    Karin Eizema
    Department of Pathobiology, Division of Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 158, NL 3508 TD, Utrecht, The Netherlands
    J Histochem Cytochem 55:247-54. 2007
    ..Although equine muscle is already functional at birth, expression patterns of the monitored proteins still show adaptation, depending on the MyHC fiber type...
  53. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
    ..We suggest that aberrant splicing of RyR1 and SERCA1 mRNAs might contribute to impaired Ca2+ homeostasis in DM1 muscle...
  54. ncbi Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers
    Martin Fluck
    M E Müller Institute for Biomechanics, Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
    Am J Physiol Regul Integr Comp Physiol 284:R792-801. 2003
    ..accumulation of tenascin-C and an increase of fibronectin in the endomysium of a proportion (8 and 15%) of muscle fibers. Large increases of tenascin-C (40-fold) and fibronectin (7-fold) mRNA within 1 day of reloading indicates the ..
  55. ncbi Calcium signaling in isolated skeletal muscle fibers investigated under "Silicone Voltage-Clamp" conditions
    Claude Collet
    Laboratoire de Physiologie des Elements Excitables, Universite Claude Bernard Lyon 1, UMR CNRS 5123, F69622 Villeurbanne, France
    Cell Biochem Biophys 40:225-36. 2004
    ..properties of the plasma membrane and intracellular signals measured with this methodology in mouse skeletal muscle fibers. Focus is given to the potency of this approach to investigate both fundamental aspects of excitation-..
  56. ncbi Endurance training induces muscle-specific changes in mitochondrial function in skinned muscle fibers
    Yan Burelle
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Appl Physiol (1985) 92:2429-38. 2002
    ....
  57. ncbi Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injury
    Kambiz Mousavi
    Department of Cellular and Molecular Medicine, University of Ottawa, Ontario K1H 8M5, Canada
    Am J Physiol Cell Physiol 283:C950-9. 2002
    ..NT treatments prevented the axotomy-induced loss of muscle mass in both EDL and SOL and of total number of muscle fibers in EDL but not in SOL...
  58. ncbi Effect of injecting primary myoblasts versus putative muscle-derived stem cells on mass and force generation in mdx mice
    Gunhild M Mueller
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hum Gene Ther 13:1081-90. 2002
    ..This may, in part, explain the failure of cellular therapy to alter the contractile properties of murine dystrophic muscle...
  59. pmc ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation
    Peggy Lafuste
    Institut National de la Santé et de la Recherche Médicale EMI 0011, Faculty of Medicine, Paris XII University, Creteil 94010, France
    Mol Biol Cell 16:861-70. 2005
    ..We conclude that both ADAM12 and alpha9beta1 integrin are expressed during postnatal human myogenic differentiation and that their interaction is mainly operative in nascent myotube growth...
  60. ncbi Nitric oxide-dependence of satellite stem cell activation and quiescence on normal skeletal muscle fibers
    Ashley C Wozniak
    Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Dev Dyn 236:240-50. 2007
    ..Results have important implications for designing new therapies that target the role of exercise in health, aging, and disease...
  61. ncbi Changes in muscle fiber conduction velocity indicate recruitment of distinct motor unit populations
    C J Houtman
    Department of Clinical Neurophysiology, Institute of Neurology, University Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Appl Physiol 95:1045-54. 2003
    ..It is most likely that the MFCV pattern can be ascribed to the fatiguing of already recruited predominantly type I motor units, followed by the recruitment of fresh, predominantly type II, motor units...
  62. ncbi Inositol-1,4,5-triphosphate receptors mediate activity-induced synaptic Ca2+ signals in muscle fibers and Ca2+ overload in slow-channel syndrome
    Roberto Zayas
    Department of Neuroscience and Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Cell Calcium 41:343-52. 2007
    ..NMJ and discovered that Ca2+ accumulates significantly faster around the NMJ of SCS transgenic dissociated muscle fibers. Additionally, we determined that this process is dependant on the activation, altered kinetics, and movement ..
  63. ncbi In vivo plasmid DNA electroporation resulted in transfection of satellite cells and lasting transgene expression in regenerated muscle fibers
    Baowei Peng
    School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, PR China
    Biochem Biophys Res Commun 338:1490-8. 2005
    ..We found that cells with longer gene expression durations were mostly regenerated muscle fibers. In contrast, expression in pre-existing muscle fibers was rather transient...
  64. ncbi Calcium sensitivity of human single muscle fibers following plyometric training
    Laurent Malisoux
    Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain la Neuve, Belgium
    Med Sci Sports Exerc 38:1901-8. 2006
    To study the effect of plyometric training on Ca2+ sensitivity and the influence of troponin T (TnT) isoforms on Ca2+ -activation properties in skinned human muscle fibers.
  65. ncbi Assessment of average muscle fiber conduction velocity from surface EMG signals during fatiguing dynamic contractions
    Dario Farina
    Center of Bioengineering, Department of Electronics, Politecnico di Torino, Torino, Italy
    IEEE Trans Biomed Eng 51:1383-93. 2004
    ..Ten subjects were investigated during a 4-min cycling task. The method provided reliable assessment of muscle fatigue for these subjects during dynamic contractions...
  66. ncbi Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers
    Thomas J Hawke
    School of Kinesiology and Health Science, York Univ, 4700 Keele St, Toronto ON Canada
    Am J Physiol Cell Physiol 293:C1636-44. 2007
    ..Taken together, the present findings support the hypothesis that Xin is expressed within muscle satellite cells during skeletal muscle regeneration and is involved in the regulation of myoblast function...
  67. ncbi Cross-bridge blocker BTS permits direct measurement of SR Ca2+ pump ATP utilization in toadfish swimbladder muscle fibers
    Iain S Young
    Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 285:C781-7. 2003
    ..Furthermore, we found that BTS also effectively eliminates force generation in bundles of intact swimbladder muscle, suggesting that it will be an important tool for studying integrated SR function during normal motor behavior...
  68. ncbi Effects of shortening on stretch-induced force enhancement in single skeletal muscle fibers
    Dilson E Rassier
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Drive, N W Calgary AB, T2N 1N4, Canada
    J Biomech 37:1305-12. 2004
    ..of this study was to evaluate the effects of shortening on the stretch-induced force enhancement in single muscle fibers, and indirectly test the hypothesis that force enhancement may be associated with the engagement of a passive ..
  69. ncbi Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin
    Simona Iezzi
    Muscle Gene Expression Group, Laboratory of Muscle Biology, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 6:673-84. 2004
    ....
  70. ncbi Non-cross-bridge calcium-dependent stiffness in frog muscle fibers
    M A Bagni
    Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, 50134 Florence, Italy
    Am J Physiol Cell Physiol 286:C1353-7. 2004
    ..This stiffness increase may help in maintaining the sarcomere length uniformity under conditions of instability...
  71. ncbi Stretch-shortening cycle exercises: an effective training paradigm to enhance power output of human single muscle fibers
    Laurent Malisoux
    Département d Education Physique et de Réadaptation, Faculte de Medecine, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    J Appl Physiol 100:771-9. 2006
    Functional performance of lower limb muscles and contractile properties of chemically skinned single muscle fibers were evaluated before and after 8 wk of maximal effort stretch-shortening cycle (SSC) exercise training...
  72. pmc Effects of tetracaine on voltage-activated calcium sparks in frog intact skeletal muscle fibers
    Stephen Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Gen Physiol 127:291-307. 2006
    The properties of Ca(2+) sparks in frog intact skeletal muscle fibers depolarized with 13 mM [K(+)] Ringer's are well described by a computational model with a Ca(2+) source flux of amplitude 2.5 pA (units of current) and duration 4...
  73. ncbi Hypertrophic muscle fibers with fissures in power-lifters; fiber splitting or defect regeneration?
    Anders Eriksson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87, Umea, Sweden
    Histochem Cell Biol 126:409-17. 2006
    Power-lifters have hypertrophic muscle fibers with fissures seen in cross-sections, called as fiber splitting. Whether this phenomenon is due to real splitting or defective regeneration has not been settled...
  74. ncbi Molecular mechanisms and therapeutics of the deficit in specific force in ageing skeletal muscle
    Osvaldo Delbono
    Department of Physiology and Pharmacology, Department of Internal Medicine, Gerontology and Neuroscience Program, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biogerontology 3:265-70. 2002
    ..The molecular, functional and structural factors supporting this theory and counteracting measures such as insulin-like growth factor 1 transgenic overexpression are discussed...
  75. ncbi Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury
    Mark A Labarge
    Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Department of Molecular Pharmacology, Stanford University School of Medicine, CCSR 4215, Stanford, CA 94305, USA
    Cell 111:589-601. 2002
    ..signals first induce BMDC to occupy the muscle stem cell niche and then to help regenerate mature muscle fibers. The stress-induced progression of BMDC to muscle satellite cell to muscle fiber results in a contribution to ..
  76. ncbi Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression
    Kwok On Lai
    Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, People s Republic of China
    J Biol Chem 279:13383-92. 2004
    ..In addition, the present study provides the first demonstration of a potential function of Eph receptors and Jak/Stat proteins at the NMJ...
  77. ncbi Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline
    Jean François Rolland
    Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
    Neurobiol Dis 24:466-74. 2006
    ..The possibility to pharmacologically counteract abnormal channel activity discloses important therapeutic application...
  78. pmc Role of protein kinase C and NF-kappaB in proteolysis-inducing factor-induced proteasome expression in C(2)C(12) myotubes
    H J Smith
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    Br J Cancer 90:1850-7. 2004
    ..This suggests that PKC may be involved in the phosphorylation and degradation of I-kappaBalpha, induced by PIF, necessary for the release of NF-kappaB from its inactive cytosolic complex...
  79. ncbi Ultrastructure of mouse striated muscle fibers following pravastatin administration
    Michael Bergman
    Department of Medicine C, Rabin Medical Center, Golda Campus, 7, Keren Kayemet St, Petah Tiqva, Israel
    J Muscle Res Cell Motil 24:417-20. 2003
    ..While the ultrastructure of the heart and liver of the treated animals appeared normal, the muscle fibers showed a marked alterations of the mitochondria, which were increased in size compared to those of the ..
  80. ncbi Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys
    Nolan G Gokey
    University of Wisconsin, Department of Animal Health and Biomedical Sciences, Madison, WI 53706, USA
    Aging Cell 3:319-26. 2004
    ..deletion mutations co-localize with electron transport system (ETS) abnormalities in rhesus monkey skeletal muscle fibers. Using laser capture microdissection in conjunction with PCR and DNA sequence analysis, mitochondrial genomes ..
  81. ncbi Intracellular PO2 kinetics at different contraction frequencies in Xenopus single skeletal muscle fibers
    Richard A Howlett
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol 102:1456-61. 2007
    Increasing contraction frequency in single skeletal muscle fibers has been shown to increase the magnitude of the fall in intracellular Po(2) (Pi(O(2))), reflecting a greater metabolic rate...
  82. ncbi Junctional and extrajunctional acetylcholinesterase in skeletal muscle fibers
    Neva Crne-Finderle
    Medical Faculty, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 157:23-7. 2005
    ..Calcineurin signalling pathway seems to be involved...
  83. ncbi BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury
    Kambiz Mousavi
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Cell Physiol 287:C22-9. 2004
    ..known to result in an extensive loss of lumbar motor neurons as well as the disappearance of their respective muscle fibers in the hindlimb musculature...
  84. ncbi Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization
    Stephane Dedieu
    Laboratoire Biosciences de l Aliment, Universite Bordeaux I, ISTAB USC INRA 429, 33405 Talence Cedex, France
    Exp Cell Res 292:187-200. 2004
    ....
  85. ncbi What controls the position, number, size, and distribution of neuromuscular junctions on rat muscle fibers?
    Terje Lømo
    Department of Physiology, University of Oslo, Norway
    J Neurocytol 32:835-48. 2003
    ..that determine the position, number, size, and distribution of neuromuscular junctions (NMJs) on skeletal muscle fibers. Most of the data reviewed derive from studies of ectopic NMJ formation on soleus (SOL) muscle fibers in adult ..
  86. ncbi Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory module
    Eun Hui Lee
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 286:C179-89. 2004
    ..Although we were unable to define the negative module using RyR1-RyR2 chimeras, they further demonstrated that the RyR is very sensitive to long-range allosterism...
  87. ncbi Regulated sarcolemmal localization of the muscle-specific ClC-1 chloride channel
    H Papponen
    Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FIN 90014, Finland
    Exp Neurol 191:163-73. 2005
    ..These data indicate that sarcolemmal targeting of the ClC-1 requires specific signals that are provided by the physiological environment...
  88. ncbi Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling
    Patrick Steigemann
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Goettingen, Germany
    Curr Biol 14:225-30. 2004
    ..The results suggest that Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells...
  89. ncbi Muscle satellite cells
    Jennifer E Morgan
    Muscle Cell Biology Group, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Int J Biochem Cell Biol 35:1151-6. 2003
    ..e. approximately 1 x 10(10) to 2 x 10(10) satellite cells per person. (2) Main functions: repair and maintenance of skeletal muscle. (3) Turnover rate: close to zero in non-traumatic conditions-high in disease or severe trauma...
  90. pmc Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse
    Ella W Yeung
    School of Medical Sciences and Institute for Biomedical Research, University of Sydney F13, NSW 2006, Australia
    J Physiol 562:367-80. 2005
    ..This result suggests that blockers of stretch-activated channels may protect against muscle damage in the intact mdx mouse...
  91. ncbi The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
    Philipp Christoph Janiesch
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 9:379-90. 2007
    ....
  92. ncbi Effects of endurance training on satellite cell frequency in skeletal muscle of old men
    Nadia Charifi
    Laboratoire de Physiologie, Groupement d Intérêt Public Exercice Sport Santé, Université Saint Etienne, Saint Etienne, France
    Muscle Nerve 28:87-92. 2003
    ..The enhancement of satellite cell frequency and fiber area indicate that endurance training is an efficient strategy to improve muscle function in the elderly...
  93. ncbi Histochemical and immunohistochemical study on muscle fibers in human extraocular muscle spindles
    Waltraut Wicke
    Medical University of Vienna, Center of Anatomy and Cell Biology, Integrative Morphology Group, Waehringer Stasse 13, 1090 Vienna, and Institute of Pathology and Bacteriology, Kaiserin Elisabeth Hospital, Austria
    Exp Eye Res 84:670-9. 2007
    ..Aim of this study was to establish a classification of intrafusal muscle fibers of human extraocular muscles based on their histochemical and immunohistochemical properties and to determine ..
  94. pmc Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers
    Pietro Fratta
    Department of Neurology, USC Neuromuscular Center, Good Samaritan Hospital, Los Angeles, CA 90017 1912, USA
    Am J Pathol 167:517-26. 2005
    ..ubiquitinated multiprotein-aggregates are characteristic of sporadic inclusion-body myositis (s-IBM) muscle fibers. Two major types of aggregates exist, containing either amyloid-beta (Abeta) or phosphorylated tau (p-tau)...
  95. ncbi Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice
    J C Bruusgaard
    Department of Molecular Biosciences, University of Oslo, PO Box 1041, Blindern NO 0316, Oslo, Norway
    J Appl Physiol 100:2024-30. 2006
    We have recently published a new technique for visualizing nuclei in living muscle fibers of intact animals, based on microinjection of labeled DNA into single myofibers, excluding satellite cells (Bruusgaard JC, Liestol K, Ekmark M, ..
  96. ncbi Design and function of superfast muscles: new insights into the physiology of skeletal muscle
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 68:193-221. 2006
    ..Hence the locomotory and sound-producing muscles have mutually exclusive designs...
  97. ncbi Effects of running exercise during recovery from hindlimb unloading on soleus muscle fibers and their spinal motoneurons in rats
    Akihiko Ishihara
    Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 48:119-27. 2004
    ..unloading and recovery with or without running exercise on morphological and metabolic properties of soleus muscle fibers and their spinal motoneurons in rats were investigated...
  98. ncbi Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes
    Mads K Holten
    Department of Medical Physiology, The Panum Institute, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 53:294-305. 2004
    ..The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade...
  99. ncbi Therapeutic clenbuterol treatment does not alter Ca2+ sensitivity of permeabilized fast muscle fibres from exercise trained or untrained horses
    David R Plant
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Muscle Res Cell Motil 24:471-6. 2003
    ..The results indicate that a therapeutic dose of clenbuterol to Standardbred horses does not affect the Ca(2+)-activated contractile characteristics of isolated muscle fibres...
  100. pmc Regulation of muscle fiber type and running endurance by PPARdelta
    Yong Xu Wang
    Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
    PLoS Biol 2:e294. 2004
    ..receptor delta (PPARdelta) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers. Treatment of wild-type mice with PPARdelta agonist elicits a similar type I fiber gene expression profile in ..
  101. pmc Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation
    Michael S Huh
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, K1H 8L6
    J Cell Biol 166:865-76. 2004
    ..Therefore, Rb plays a crucial role in the switch from proliferation to differentiation rather than maintenance of the terminally differentiated state...

Research Grants78

  1. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2004
    ..multiple nerves, each of which supplies a distinct region within the muscle, and that it contains specialized muscle fibers. One of these, slow tonic muscle fibers (STMF) has a unique physiology...
  2. The Anatomical Basis of Human Tongue Biomechanics
    Ira Sanders; Fiscal Year: 2003
    ..by staining to show details of muscle structure and insertion into connective tissue; 4) micro dissection of muscle fibers followed by silver and acetylcholinesterase staining to study details of muscle fiber size and shape, motor ..
  3. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2010
    ..This functional characterization will be achieved in muscle fibers from various animal models of human muscular dystrophies...
  4. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna Cordary; Fiscal Year: 2010
    ..We will examine this hypothesis at the single molecule level in papillary muscle fibers from transgenic mouse hearts which carry disease-causing mutations in the regulatory and/or essential light ..
  5. Synaptic target selection in Drosophila
    KAI G ZINN; Fiscal Year: 2010
    ..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...
  6. MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZE
    Paul J May; Fiscal Year: 2010
    ..motor neurons that control the lens and pupil, and the motor neurons that control the multiply innervated muscle fibers (MIFs) in the extraocular muscles. MIFs are highly fatigue resistant and tonically active...
  7. Role of Type I Interferons in a Self-Sustaining Murine Model of Myositis
    Thomas Griffin; Fiscal Year: 2007
    ..excessive expression of MHC class I molecules and an associated unfolded protein response (UPR) in affected muscle fibers in each of these conditions suggests a common mechanism for chronic muscle fiber injury...
  8. Role of Troponin T Isoforms in Amish Nemaline Myopathy
    Jian Ping Jin; Fiscal Year: 2007
    ..are neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers Recent studies have identified a recessively inherited form of nemaline myopathy, the Amish nemaline myopathy (..
  9. ALPHA 7 BETA1 INTEGRIN AND MUSCLE INTEGRITY
    Stephen Kaufman; Fiscal Year: 2000
    DESCRIPTION (adapted from investigator's abstract): The proper association of muscle fibers with their extracellular matrix is essential to the normal functioning of skeletal muscle...
  10. Role of actin domains in force generation in myocardium
    Masataka Kawai; Fiscal Year: 2010
    ..Our research involves selectively removing the thin filament from cardiac muscle fibers (myocardium) by gelsolin treatment, and sequentially reconstituting the thin filament with G-actin and the ..
  11. Role of actin domains in force generation in myocardium
    Masataka Kawai; Fiscal Year: 2009
    ..Our research involves selectively removing the thin filament from cardiac muscle fibers (myocardium) by gelsolin treatment, and sequentially reconstituting the thin filament with G-actin and the ..
  12. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2007
    ..Another important finding was that the adult pharyngeal muscles contained muscle fibers expressing unusual myosin heavy chain (MHC) isoforms (slow-tonic and alpha-cardiac) which were concentrated ..
  13. Impact of Exercise on Sarcopenia
    Judd Aiken; Fiscal Year: 2009
    ..We have shown that age-dependent mtDNA deletion mutations clonally accumulate to high levels in aged skeletal muscle fibers. Concomitant with this increase in aberrant genomes is a loss of complex IV (cytochrome c oxidase; COX-) ..
  14. Impact of Exercise on Sarcopenia
    Judd M Aiken; Fiscal Year: 2010
    ..We have shown that age-dependent mtDNA deletion mutations clonally accumulate to high levels in aged skeletal muscle fibers. Concomitant with this increase in aberrant genomes is a loss of complex IV (cytochrome c oxidase;COX-) ..
  15. Spectroscopy of myosin light chain domain dynamics
    Osha Roopnarine; Fiscal Year: 2007
    ..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
  16. Spectroscopy of myosin light chain domain dynamics
    Osha Roopnarine; Fiscal Year: 2010
    ..Most of these experiments will be performed on skinned muscle fibers, so that structural dynamics and function can be measured simultaneously on the same sample...
  17. SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTOR
    STEVEN BURDEN; Fiscal Year: 2002
    ..Abstract) Neuromuscular synapses form as a result of inductive interactions between motor neurons and muscle fibers. Following contact with the growth cone of a developing motor neuron, developing muscle fibers undergo a ..
  18. Respiratory Muscle Weakness in Chronic Inflammation
    Michael B Reid; Fiscal Year: 2010
    ..TNF depresses contractile function of diaphragm and stimulates oxidant production by diaphragm muscle fibers. The oxidants appear to cause weakness since interventions that limit oxidant activity prevent loss of force...
  19. Synaptic target selection in Drosophila
    KAI G ZINN; Fiscal Year: 2010
    ..that regulate axon guidance in this system have been identified, we know very little about how individual muscle fibers are recognized as targets by motor axons...