skin

Summary

Summary: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Top Publications

  1. pmc Bacterial community variation in human body habitats across space and time
    Elizabeth K Costello
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
    Science 326:1694-7. 2009
  2. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
  3. ncbi Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
  4. ncbi Telocytes in human skin--are they involved in skin regeneration?
    Laura Ceafalan
    Molecular Medicine Laboratory, V Babeş National Institute of Pathology, Bucharest, Romania
    J Cell Mol Med 16:1405-20. 2012
  5. pmc Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
    Alexej Abyzov
    Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA
    Nature 492:438-42. 2012
  6. pmc Topographical and temporal diversity of the human skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Science 324:1190-2. 2009
  7. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
  8. pmc The skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4442, USA
    Nat Rev Microbiol 9:244-53. 2011
  9. pmc Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
    Jun Ding
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Am J Hum Genet 87:779-89. 2010
  10. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008

Detail Information

Publications336 found, 100 shown here

  1. pmc Bacterial community variation in human body habitats across space and time
    Elizabeth K Costello
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
    Science 326:1694-7. 2009
    ..Several skin locations harbored more diverse communities than the gut and mouth, and skin locations differed in their community ..
  2. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
    The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages...
  3. ncbi Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
    ..It is well described at the histological level, but the genes that regulate skin repair have only partially been identified...
  4. ncbi Telocytes in human skin--are they involved in skin regeneration?
    Laura Ceafalan
    Molecular Medicine Laboratory, V Babeş National Institute of Pathology, Bucharest, Romania
    J Cell Mol Med 16:1405-20. 2012
    ..Given the frequency of allergic skin pathologies, we would like to emphasize the finding that close, planar junctions were frequently observed between ..
  5. pmc Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
    Alexej Abyzov
    Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA
    Nature 492:438-42. 2012
    ..issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generation sequencing...
  6. pmc Topographical and temporal diversity of the human skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Science 324:1190-2. 2009
    Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease...
  7. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
    ..Here we show that the persistence of Leishmania major in the skin after healing in resistant C57BL/6 mice is controlled by an endogenous population of CD4+CD25+ regulatory T cells...
  8. pmc The skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4442, USA
    Nat Rev Microbiol 9:244-53. 2011
    The skin is the human body's largest organ, colonized by a diverse milieu of microorganisms, most of which are harmless or even beneficial to their host...
  9. pmc Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
    Jun Ding
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Am J Hum Genet 87:779-89. 2010
    Psoriasis, an immune-mediated, inflammatory disease of the skin and joints, provides an ideal system for expression quantitative trait locus (eQTL) analysis, because it has a strong genetic basis and disease-relevant tissue (skin) is ..
  10. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008
    ..Our results suggest that factors released by BM-MSCs recruit macrophages and endothelial lineage cells into the wound thus enhancing wound healing...
  11. ncbi Inflammation in wound repair: molecular and cellular mechanisms
    Sabine A Eming
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:514-25. 2007
    ..In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response...
  12. pmc Epithelial antimicrobial defence of the skin and intestine
    Richard L Gallo
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California 92093, USA
    Nat Rev Immunol 12:503-16. 2012
    Surface tissues of the body such as the skin and intestinal tract are in direct contact with the external environment and are thus continuously exposed to large numbers of microorganisms...
  13. ncbi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation...
  14. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Upon activation, mature skin dendritic cells fail to migrate into the draining lymph nodes...
  15. pmc Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin
    Rachel M Schowalter
    Tumor Virus Molecular Biology Section, Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Cell Host Microbe 7:509-15. 2010
    ..polyomavirus (MCV), a circular double-stranded DNA virus, is a causal factor underlying a highly lethal form of skin cancer known as Merkel cell carcinoma...
  16. pmc Epidermal homeostasis: a balancing act of stem cells in the skin
    Cedric Blanpain
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Nat Rev Mol Cell Biol 10:207-17. 2009
    The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis...
  17. pmc Human skin microbiota: high diversity of DNA viruses identified on the human skin by high throughput sequencing
    Vincent Foulongne
    Institut National de la Santé et de la Recherche Médicale U1058 University of Montpellier I Montpellier University Hospital, Department of Biology and Pathology, Montpellier, France
    PLoS ONE 7:e38499. 2012
    The human skin is a complex ecosystem that hosts a heterogeneous flora...
  18. pmc Compartmentalized control of skin immunity by resident commensals
    Shruti Naik
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 337:1115-9. 2012
    ..We found that in mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte ..
  19. ncbi A skin microRNA promotes differentiation by repressing 'stemness'
    Rui Yi
    Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10065, USA
    Nature 452:225-9. 2008
    ..Here, we show that microRNA-203 is induced in the skin concomitantly with stratification and differentiation...
  20. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..Thus, our data suggest that BM-MSCs promote wound healing through differentiation and release of proangiogenic factors. Disclosure of potential conflicts of interest is found at the end of this article...
  21. ncbi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
    ..Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell...
  22. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
    ..For the immediate future, our challenge is to define the molecular basis for hair follicle growth control, to regenerate a mature hair follicle in vitro from defined populations, and to offer real solutions to our patients' problems...
  23. ncbi Pathogenesis and therapy of psoriasis
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA
    Nature 445:866-73. 2007
    Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings...
  24. pmc Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
    Keisuke Nagao
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Nat Immunol 13:744-52. 2012
    ..Pre-LCs failed to enter hairless skin in mice or humans, which establishes hair follicles as portals for LCs.
  25. pmc Diversity of the human skin microbiome early in life
    Kimberly A Capone
    Department of Microbiology, Johnson and Johnson Consumer Companies, Skillman, New Jersey, USA
    J Invest Dermatol 131:2026-32. 2011
    Within days after birth, rapid surface colonization of infant skin coincides with significant functional changes. Gradual maturation of skin function, structure, and composition continues throughout the first years of life...
  26. pmc Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, and Bethesda, Maryland, USA
    J Infect Dis 204:937-41. 2011
    ..The role of PVL in the success of the epidemic CA-MRSA strain USA300 remains unknown. Here we developed a skin and soft tissue infection model in rabbits to test the hypothesis that PVL contributes to USA300 pathogenesis and ..
  27. pmc Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
    Cory L Simpson
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 12:565-80. 2011
    ..These architectural components are more than just rivets and scaffolds - they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation...
  28. pmc Asymmetric cell divisions promote stratification and differentiation of mammalian skin
    Terry Lechler
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 437:275-80. 2005
    ..We further demonstrate that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3-LGN-Inscuteable complex and NuMA-dynactin to align the spindle...
  29. pmc Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 202:1050-8. 2010
    ..methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are predominantly those affecting skin and soft tissues...
  30. ncbi Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006
    ..We cloned more than 100 miRNAs from skin and show that epidermis and hair follicles differentially express discrete miRNA families...
  31. pmc Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America
    L Berger
    School of Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4811, Australia
    Proc Natl Acad Sci U S A 95:9031-6. 1998
    ..Experimental data support the conclusion that cutaneous chytridiomycosis is a fatal disease of anurans, and we hypothesize that it is the proximate cause of these recent amphibian declines...
  32. pmc IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and Maternal Fetal Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:4448-53. 2010
    ..is significantly increased in affected and unaffected (at least 15 cm away from the lesion) psoriatic skin, as compared with normal control skin...
  33. pmc Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling
    Eric Festa
    Department of Molecular Biology, Yale University, 219 Prospect St, New Haven, CT 06520, USA
    Cell 146:761-71. 2011
    In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration...
  34. pmc Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
    M Zasloff
    Proc Natl Acad Sci U S A 84:5449-53. 1987
    A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis...
  35. ncbi Differential roles of macrophages in diverse phases of skin repair
    Tina Lucas
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 184:3964-77. 2010
    ..We tested the hypothesis that macrophages recruited during the diverse phases of skin repair after mechanical injury exert specific functions to restore tissue integrity...
  36. ncbi De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    U Gat
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Cell 95:605-14. 1998
    ..Our findings suggest that transient beta-catenin stabilization may be a key player in the long-sought epidermal signal leading to hair development and implicate aberrant beta-catenin activation in hair tumors...
  37. pmc p63 is the molecular switch for initiation of an epithelial stratification program
    Maranke I Koster
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 18:126-31. 2004
    ..Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis...
  38. ncbi Neuroendocrinology of the skin
    A Slominski
    Department of Pathology, University of Tennessee, Memphis 38163, USA
    Endocr Rev 21:457-87. 2000
    The classical observations of the skin as a target for melanotropins have been complemented by the discovery of their actual production at the local level...
  39. ncbi Isolation and characterization of multipotent skin-derived precursors from human skin
    Jean G Toma
    Department of Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Stem Cells 23:727-37. 2005
    We have previously isolated, expanded, and characterized a multipotent precursor cell from mammalian dermis (termed skin-derived precursors [SKPs]) that can differentiate into both neural and mesodermal progeny...
  40. ncbi Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
    ..TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation...
  41. pmc Co-habiting amphibian species harbor unique skin bacterial communities in wild populations
    Valerie J McKenzie
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309 0334, USA
    ISME J 6:588-96. 2012
    ..We compared the diversity and composition of the bacterial communities on the skin of the collected individuals via barcoded pyrosequencing of the 16S rRNA gene...
  42. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  43. pmc MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R
    Galya Lerman
    Laboratory of Molecular Cell Biology, Center for Cancer Research and Department of Internal Medicine C, Sheba Medical Center, Tel Hashomer, Israel
    PLoS ONE 6:e20916. 2011
    Psoriasis is a complex disease at the cellular, genomic and genetic levels. The role of microRNAs in skin development was shown in a keratinocyte-specific Dicer knockout mouse model...
  44. ncbi Characterization of skin ulceration syndrome associated microRNAs in sea cucumber Apostichopus japonicus by deep sequencing
    Chenghua Li
    School of Marine Science, Ningbo University, Ningbo, Zhejiang Province, PR China
    Fish Shellfish Immunol 33:436-41. 2012
    ..two haemocytes miRNA libraries were constructed with deep sequenced by illumina Hiseq2000 from healthy (L1) and skin ulceration syndrome Apostichopus japonicus (L2)...
  45. pmc DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
    Christoph Bock
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Mol Cell 47:633-47. 2012
    ..maps of adult stem cell differentiation in mouse, focusing on 19 purified cell populations of the blood and skin lineages. DNA methylation changes were locus specific and relatively modest in magnitude...
  46. pmc Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells
    Julien Seneschal
    Department of Dermatology Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 36:873-84. 2012
    Recent studies have demonstrated that the skin of a normal adult human contains 10-20 billion resident memory T cells, including various helper, cytotoxic, and regulatory T cell subsets, that are poised to respond to environmental ..
  47. ncbi Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Tissue Eng 13:1299-312. 2007
    ..A single bone marrow aspirate of 35-50 mL was obtained from patients with acute wounds (n = 5) from skin cancer surgery and from patients with chronic, long-standing, nonhealing lower extremity wounds (n = 8)...
  48. ncbi Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins...
  49. ncbi Mechanisms of photoaging and chronological skin aging
    Gary J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Dermatol 138:1462-70. 2002
    Human skin, like all other organs, undergoes chronological aging. In addition, unlike other organs, skin is in direct contact with the environment and therefore undergoes aging as a consequence of environmental damage...
  50. pmc Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    Xiao ding Peng
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 17:1352-65. 2003
    ..These mice display impaired skin development because of a proliferation defect, severe skeletal muscle atrophy because of a marked decrease in ..
  51. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008
    Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs...
  52. pmc Skin microbiome: genomics-based insights into the diversity and role of skin microbes
    Heidi H Kong
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Drive, Bldg 10, Rm 12N238, Bethesda, MD 20892, USA
    Trends Mol Med 17:320-8. 2011
    Recent advances in DNA sequencing methodology have facilitated studies of human skin microbes that circumvent difficulties in isolating and characterizing fastidious microbes...
  53. ncbi Bat white-nose syndrome: an emerging fungal pathogen?
    David S Blehert
    National Wildlife Health Center, U S Geological Survey USGS, 6006 Schroeder Road, Madison, WI 53711, USA
    Science 323:227. 2009
    ..Direct microscopy and culture analyses demonstrated that the skin of WNS-affected bats is colonized by a psychrophilic fungus that is phylogenetically related to Geomyces spp...
  54. ncbi R-spondin1 is essential in sex determination, skin differentiation and malignancy
    Pietro Parma
    Dipartimento di Patologia Umana ed Ereditaria, Sezione di Biologia Generale e Genetica Medica, Universita di Pavia, Via Forlanini 14, 27100 Pavia, Italy
    Nat Genet 38:1304-9. 2006
    ..characterized by XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Our data show, for the first time, that disruption of a single gene can lead to complete female-to-male sex ..
  55. ncbi Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..In parabiotic mice with separate organs, but a shared blood circulation, there was no mixing of LCs. However, in skin exposed to ultraviolet light, LCs rapidly disappeared and were replaced by circulating LC precursors within 2 weeks...
  56. ncbi Macrophages in skin injury and repair
    Babak Mahdavian Delavary
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 216:753-62. 2011
    ..This review summarizes macrophage function in skin injury repair, thereby providing more insight in macrophage function in wound healing and possible interventions in ..
  57. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ..release IL-10 or interferon (IFN)-gamma, and were found to accumulate in chronic sites of infection, including the skin and draining lymph node. A high frequency of the dermal CD4+ T cells released both IL-10 and IFN-gamma...
  58. pmc Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis
    Mayte Suárez-Fariñas
    Laboratory of Investigative Dermatology, Rockefeller University, New York, New York, USA
    J Invest Dermatol 132:2552-64. 2012
    ..known genes) as being differentially expressed in psoriasis lesions compared with matched biopsies of non-lesional skin when the following criteria were applied: >2-fold change and false discovery rate <0.05...
  59. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and is often the first step in the atopic march that results in asthma and allergic rhinitis...
  60. pmc Skin barrier disruption: a requirement for allergen sensitization?
    Anna De Benedetto
    Department of Dermatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Invest Dermatol 132:949-63. 2012
    For at least half a century, noninvasive techniques have been available to quantify skin barrier function, and these have shown that a number of human skin conditions and disorders are associated with defects in skin permeability...
  61. pmc Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome
    Cailin E Joyce
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 20:4025-40. 2011
    Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying dramatically altered mRNA expression profiles. However, much less is known about the expression of small RNAs...
  62. pmc The role of connexins in ear and skin physiology - functional insights from disease-associated mutations
    Ji Xu
    Department of Physiology, University of California, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1828:167-78. 2013
    ..Other mutations in Cx26 or Cx30 have also been associated with various skin phenotypes linked to deafness (palmoplanta keratoderma, Bart-Pumphrey syndrome, Vohwinkel syndrome, keratitis-..
  63. pmc Hair follicle stem cells are specified and function in early skin morphogenesis
    Jonathan A Nowak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 3:33-43. 2008
    In adult skin, epithelial hair follicle stem cells (SCs) reside in a quiescent niche and are essential for cyclic bouts of hair growth. Niche architecture becomes pronounced postnatally at the start of the first hair cycle...
  64. pmc Scratching the surface of skin development
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nature 445:834-42. 2007
    ..Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-..
  65. pmc Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential
    May Al-Nbaheen
    Stem Cell Unit, Department of Anatomy 28, College of Medicine, King Saud University, P O Box 2925, Riyadh, 11461, Kingdom of Saudi Arabia
    Stem Cell Rev 9:32-43. 2013
    ..Here, we compared the MSC-like cell populations, obtained from alternative sources for MSC: adipose tissue and skin, with the standard phenotype of human bone marrow MSC (BM-MSCs)...
  66. pmc DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling
    Orna Tal
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 208:2141-53. 2011
    Dendritic cells (DCs) must travel through lymphatics to carry skin antigens into lymph nodes. The processes controlling their mobilization and migration have not been completely delineated...
  67. ncbi Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor
    Fanghua Qi
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Int Immunopharmacol 11:342-9. 2011
    The skin of the toad Bufo bufo gargarizans Cantor is known to be rich in bufadienolides, peptides and alkaloids. It has been found to be a source of some extracts and biologically active compounds with antitumor activity...
  68. ncbi Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice
    Zi Qing Lin
    Faculty of Forensic Medicine, China Criminal Police College, Shenyang, China
    J Leukoc Biol 73:713-21. 2003
    To clarify interleukin (IL)-6 roles in wound healing, we prepared skin excisions in wild-type (WT) and IL-6-deficient BALB/c [knockout (KO)] mice. In WT mice, the wound area was reduced to 50% of original size at 6 days after injury...
  69. ncbi Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4
    Mayumi Egawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo 113 8519, Japan
    Immunity 38:570-80. 2013
    ..Here we show that inflammatory monocytes recruited to allergic skin acquired an M2-like phenotype in response to basophil-derived interleukin-4 (IL-4) and exerted an anti-inflammatory ..
  70. ncbi Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 115:1958-68. 2010
    ..RA-producing DCs were primarily of the tissue-derived, migratory DC subtype and can be readily found in the skin and in the lungs as well as in their corresponding draining lymph nodes...
  71. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..Here we show in mice that localized vaccinia virus (VACV) skin infection generates long-lived non-recirculating CD8(+) skin T(RM) cells that reside within the entire skin...
  72. ncbi Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Thomas Gebhardt
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia
    Nat Immunol 10:524-30. 2009
    ..a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia...
  73. pmc Induced pluripotent stem cells from a spinal muscular atrophy patient
    Allison D Ebert
    The Waisman Center, The Stem Cell and Regenerative Medicine Center, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Nature 457:277-80. 2009
    ..Here we report the generation of induced pluripotent stem cells from skin fibroblast samples taken from a child with spinal muscular atrophy...
  74. pmc Skin immune sentinels in health and disease
    Frank O Nestle
    St John s Institute of Dermatology, King s College London, UK
    Nat Rev Immunol 9:679-91. 2009
    Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome...
  75. ncbi Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
    C Campagnoli
    Department of Maternal and Fetal Medicine, Institute of Reproductive and Developmental Biology, Imperial College School of Medicine, London, United Kingdom
    Blood 98:2396-402. 2001
    ..MSCs similar to those derived from adult bone marrow, fetal liver, and fetal bone marrow circulate in first-trimester human blood and may provide novel targets for in utero cellular and gene therapy...
  76. pmc Selective and specific macrophage ablation is detrimental to wound healing in mice
    Rita Mirza
    Department of Kinesiology and Nutrition, Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Pathol 175:2454-62. 2009
    ..The purpose of this study was to test the hypothesis that specific depletion of macrophages after excisional skin wounding would detrimentally affect healing by reducing the production of growth factors important in the repair ..
  77. ncbi Multilineage differentiation potential of human dermal skin-derived fibroblasts
    Katrin Lorenz
    Department of Cell Techniques and Applied Stem Cell Biology, Biotechnological Biomedical Center, University of Leipzig, Leipzig, Germany
    Exp Dermatol 17:925-32. 2008
    Dermal skin-derived fibroblasts from rodent and human have been found to exhibit mesenchymal surface antigen immunophenotype and differentiation potential along the three main mesenchymal-derived tissues: bone, cartilage and fat...
  78. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
    ..We report that mice harboring a targeted disruption of the decorin gene are viable but have fragile skin with markedly reduced tensile strength...
  79. pmc RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
    Ben Jackson
    Biomedical Institute, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark
    Mol Biol Cell 22:593-605. 2011
    ..In skin, loss of RhoA was suggested to underlie pemphigus skin blistering...
  80. ncbi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
    b>Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens...
  81. ncbi Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
    We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle ..
  82. pmc Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons
    Liang Qiang
    Departments of Pathology, Cell Biology, and Neurology and Taub Institute, Columbia University, New York, NY 10032, USA
    Cell 146:359-71. 2011
    ..Here, we describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators ..
  83. pmc Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Immunity 37:60-73. 2012
    ..Cutaneous CD141(hi) DCs were closely related to blood CD141(+) DCs, and migratory counterparts were found among skin-draining lymph node DCs...
  84. pmc Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
    Heidi H Kong
    Dermatology Branch, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Genome Res 22:850-9. 2012
    Atopic dermatitis (AD) has long been associated with Staphylococcus aureus skin colonization or infection and is typically managed with regimens that include antimicrobial therapies...
  85. pmc The ability of the skin to absorb heat; the effect of repeated exposure and age
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 17:CR1-8. 2011
    When heat is applied to the skin, it is dissipated due to conductive heat flow in the tissue and the blood...
  86. ncbi A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs
    Zhang Wenguang
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Nei Mongol Autonomous Region, Hohhot, PR China
    OMICS 11:385-96. 2007
    ..miRNAs that might function in hair growth, we characterized the expression of 159 miRNAs in adult body side skin and ear skin from goat and sheep using microarray analysis...
  87. ncbi Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation
    Rieneke van de Ven
    Departments of Medical Oncology, VU University Medical Center Cancer Center Amsterdam, De Boelelaan, Amsterdam, The Netherlands
    Blood 118:2502-10. 2011
    ..In this study we identified and functionally tested 4 human conventional DC (cDC) subsets within skin-draining sentinel lymph nodes (SLNs) from early-stage melanoma patients...
  88. ncbi Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis
    Kenneth R Feingold
    Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 48:2531-46. 2007
    ..Topical application of physiologic lipids can improve permeability barrier homeostasis and has been useful in the treatment of cutaneous disorders...
  89. ncbi Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin
    Igor Adameyko
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    Cell 139:366-79. 2009
    ..crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin. Here, we identify growing nerves projecting throughout the body as a stem/progenitor niche containing Schwann cell ..
  90. ncbi Perp is a p63-regulated gene essential for epithelial integrity
    Rebecca A Ihrie
    Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell 120:843-56. 2005
    ..important for tissue integrity, and numerous structural defects in desmosomes are observed in Perp-deficient skin, suggesting a role for Perp in promoting the stable assembly of desmosomal adhesive complexes...
  91. ncbi Strain-dependent epithelial defects in mice lacking the EGF receptor
    M Sibilia
    Institute of Molecular Pathology IMP, Vienna, Austria
    Science 269:234-8. 1995
    ..These results indicate that the EGFR regulates epithelial proliferation and differentiation and that the genetic background influences the resulting phenotype...
  92. ncbi Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
    J M Jungersted
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
    Allergy 65:911-8. 2010
    Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in ..
  93. ncbi Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type
    Mikako Sasaki
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7 Kita ku, Sapporo, Japan
    J Immunol 180:2581-7. 2008
    ..In this study, we assessed whether MSCs can differentiate into multiple skin cell types including keratinocytes and contribute to wound repair...
  94. pmc Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    Fadi Issa
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 90:1321-7. 2010
    ..most complex defects, but its use is limited because of harmful immunosuppression and the high susceptibility of skin to rejection...
  95. pmc Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    Edmund Lee
    Laboratory for Investigative Dermatology, The Rockefeller University Hospital, P O Box 178, 1230 York Avenue, New York, NY 10021, USA
    J Exp Med 199:125-30. 2004
    ..a role in the recruitment of inflammatory cells in a T helper cell (Th)1-mediated disease, we examined psoriasis skin lesions for production of this newly described cytokine...
  96. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    ..These observations suggest a potential therapeutic approach for healing wounds in diabetic patients...
  97. ncbi Pathophysiology of acute wound healing
    Jie Li
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin Dermatol 25:9-18. 2007
    ..healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a ..
  98. pmc Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
    Demeng Chen
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1522-33. 2012
    Dermal fibroblasts are required for structural integrity of the skin and for hair follicle development...
  99. pmc Type I interferon: potential therapeutic target for psoriasis?
    Yihong Yao
    MedImmune, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 3:e2737. 2008
    ..To better understand the pathogenesis of this disease and identify potential mediators, we used whole genome array analysis to profile paired lesional and nonlesional psoriatic skin and skin from healthy donors.
  100. ncbi Molecular mechanisms regulating hair follicle development
    Sarah E Millar
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 118:216-25. 2002
    ..The importance of the hair follicle in skin biology, however, does not rest solely with its ability to produce hair...
  101. ncbi Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis
    M Nermes
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 41:370-7. 2011
    ..The maturational events in the gut parallel its step-wise colonization. Atopic dermatitis (AD) is associated with aberrant barrier functions of the skin epithelium and, in a subgroup of patients, of the gut mucosa.

Research Grants80

  1. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ..is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Adult participants may also provide a skin sample. - Tissue or fluid from eye collected as part of eye care or treatment may also be added to the database...
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Adult participants may also provide a skin sample. - Tissue or fluid from eye collected as part of eye care or treatment may also be added to the database...
  4. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..The LLNA was subsequently incorporated into national and international test guidelines for the assessment of skin sensitization. Accidental eye injury is a leading cause of visual impairment in the U.S...
  5. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..The LLNA was subsequently incorporated into national and international test guidelines for the assessment of skin sensitization. Accidental eye injury is a leading cause of visual impairment in the U.S...
  6. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..shown that Brn3a and Islet1 are required for pain receptor neurons to correctly connect to their targets in the skin, muscles and spinal cord...
  7. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..will investigate whether injection of NGF and NGF activated autologus T lymphocytes induce psoriasis in nonlesional skin transplant in the SCID mouse-human skin xenograft model...
  8. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The primary function of the skin is to serve as a protective barrier against the environment...
  9. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..extensive studies of transgenic mice and human tissues, we have identified galectin-3 as a key molecule involved in skin inflammation. We have begun to characterize drugs targeting galectin-3 for treatment of eczema...
  10. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..cause associated with early transient inflammation and vascular injury followed by progressive fibrosis affecting skin and internal organs;most frequently esophagus, kidneys, heart, and lungs (I)...
  11. ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESIS
    Enrique A Mesri; Fiscal Year: 2013
    ..The tumor is characterized by intense angiogenesis and the proliferation of spindle cells that can affect the skin, mucosa and viscera, causing significant morbidity...
  12. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..b>Skin grafting between two genetically distinct mouse strains will be used to test the ability of the ex vivo IL-10 gene ..
  13. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..Biomarkers that respond to CR and certain mADF regimens include global cell proliferation (mammary, prostate, skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin sensitivity, and vascular smooth muscle ..
  14. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..expression of CD88;discovering the activating form of FcyRII, CD32a, constitutively expressed on the surface of skin MCTC cells;and finding Syk-deficiency in basophils with the non-releaser phenotype and in mast cells after antigen ..
  15. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..While acne vulgaris is the most prevalent skin disorder in humans, the other diseases are also relatively common...
  16. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..pharyngitis, an infection state commonly referred to as 'strep throat', but it is also implicated in skin and soft tissue infections, as well as life threatening invasive disease and the post-streptococcal autoimmune ..
  17. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..Dermal Toxicity Testing The evaluation and development of alternatives for dermal (skin) safety testing is also one of ICCVAM's four highest priorities because it is required by multiple agencies as ..
  18. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..with generation of INrf2 conditional knockout mice that do not express INrf2 protein in liver and epidermis of skin. The Cre-Lox system will be used to generate these mice...
  19. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..We will identify peripheral blood cell and skin gene expression patterns that can predict the course of ILD...
  20. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and
  21. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..who are not breastfed suffer increased health problems such as ear infections, lower respiratory tract infections, skin rashes similar to eczema, asthmatic episodes, type I and type II diabetes, episodes of infant diarrhea, and ..
  22. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..environmental carcinogen and that repeated exposures can lead to the development of melanoma and nonmelanoma skin cancers...
  23. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..AIM 2: Determine the optimal physico-chemical properties of NPSs for skin penetration and LC activation, and the mechanisms underlying OVA-specific immune induction by NPS...
  24. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..In preliminary studies, to develop human models of TS, I reprogrammed human skin cells from two TS patients to generate induced pluripotent stem cells (iPSCs) and differentiated these cells into ..
  25. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..In preliminary studies, to develop human models of TS, I reprogrammed human skin cells from two TS patients to generate induced pluripotent stem cells (iPSCs) and differentiated these cells into ..
  26. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..spices, condiments, liquids (water, wine, coffee beer, tea) and all materials placed on the subject/patient's skin such as: lotions, perfumes, cosmetics (lipstick, makeup), soaps, shampoos, deodorant, etc...
  27. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..broad Challenge Area (11): Regenerative Medicine, and specific Challenge Topic 11-AR-101 Musculoskeletal and Skin Regeneration Every year, over a million Americans are hospitalized for bone fractures at a cumulative cost of over $..
  28. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..We implant the pump under the skin of the back and run a catheter under the skin and under the fascia of the muscle carrying the luciferase-expressing ..
  29. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..This process is referred to as graft-versus-host disease (GVHD), and can result in a severe skin rash, profound diarrhea, or liver injury...
  30. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..HIV through primary human genital epithelial cells;v) blocks infection of dendritic and Langerhans cells ex vivo (skin tissues);vi) prevents HIV transfer from dendritic and Langerhans cells to T cells ex vivo;vii) is extremely ..
  31. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..the AA amyloid protein in different organs throughout the body including heart, kidney, liver, spleen, lungs, skin and gastrointestinal tract, whereby such amyloid fibril accumulation leads to pronounced organ dysfunction...
  32. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..may act individually or in concert to monitor and report on a variety of baby vital signs, including ECG, pulse-ox, skin temperature, motion detection, EPG, and blood pressure...
  33. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2013
    ..to DNA damage, defects in DNA repair and cell cycle checkpoints, as well as lead to the development of cataracts or skin cancer. Therefore, it is important to understand mechanisms that regulate RAD9 levels...
  34. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..juvenile idiopathic arthritis (SJIA)] that afflict adults and children, as well as organ systems including joints, skin, blood elements, and blood vessels, and will both test efficacy of therapy and develop tests to characterize the ..
  35. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    More than 1 million cases of nonmelanoma skin cancer and 59,600 cases of melanoma are diagnosed yearly in the United States, resulting in about 10,600 deaths (about 7,800 due to melanoma) in 2005...
  36. CPG METHYLATION AND MUTATION
    Gerd P Pfeifer; Fiscal Year: 2013
    ..DNA methylation changes will be analyzed in a mouse skin carcinogenesis model in order to determine if epigenetic changes arise during the initiation or promotion of stages ..
  37. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..The environmental factors are mostly the factors that have direct interaction with our skin and mucosal systems...
  38. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..These conditional SHP-1 mutant animals develop a spectrum of diseases, including severe skin inflammation, autoimmunity or lethal pulmonary inflammation...
  39. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..Progerin is elevated in skin fibroblasts of healthy older individuals due to sporadic use of the cryptic splice site in exon 11...
  40. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..taking her research in a new direction to study the therapeutic potential of p53-induced repigmentation in vitiligo skin. For this, she chose her mentoring committee among the best in the skin research field: Dr...
  41. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..They are responsible for clinically important infections that cause a wide variety of maladies including pneumonia, skin and wound infections, bacteremia and meningitis. In addition, A...
  42. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  43. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..We hypothesize: 1) Decreased quality of life in chronic JDM is related less to weakness than to the chronic skin involvement, associated with long untreated disease, and, 2) identification of epigenetic regulatory mechanisms and ..
  44. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..singly and in combination to deliver antimicrobial PS (and iodide) into ex vivo pigskin and into hairless mouse skin. Aim 3 responds to the reviewers'criticisms by exploring the combination of PDT with traditional systemic ..
  45. P38 MAP KINASE SIGNALING IN SKIN
    Tatiana Efimova; Fiscal Year: 2013
    ..Using mice with germline deletion of p384 gene, we recently discovered that p384 is required for de-novo skin tumor development during two-stage chemical carcinogenesis...
  46. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Our collaborators at Wyeth found that Th17 cells mediated extensive skin disease in a transplantation model for psoriasis and that blocking the function of IL-22 produced by Th17 cells ..
  47. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..Toll-like receptor agonists that enhance immune responses against infectious agents when simply applied to the skin. In this proposal we will amplify these proof-of-concept studies and expand them to rodent models of cutaneous ..
  48. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..the relationships of frequency, acceleration, amplitude and duration to structural damage of the innervation of skin, artery and skeletal muscle and the functional deficits related to loss of feeling and muscle weakness (nerve ..
  49. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..Our lab studies skin signaling which mediates UV induced pigmentation...
  50. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..We have also tested quinacrine and a compound derived from initial SAR in a skin U87-MG xenograft in mice and found a significant reduction of tumor growth in a two week single agent ..
  51. Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's Disease
    Bruce A Yankner; Fiscal Year: 2010
    ..disease by exploring the physiology and epigenetics of iPS cells and iPS cell-derived neurons generated from skin fibroblasts of individuals at different ages and with AD...
  52. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..Accounting for an estimated ~70,000 new diagnoses and ~8,800 deaths in 2011, malignant melanoma is the most lethal skin cancer, representing ~8% of total cancers cases in the United States...
  53. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..We desire to detect important biomarkers associated with the onset of skin cancers, with a particular emphasis on melanoma...
  54. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..Therefore, diabetics must rely on either finger pricking (approximately five times per day) or microprobe, skin-penetrating devices that need to be replaced every 3-7 days due to their open-wound nature and associated negative ..
  55. Durable Visible Light-activated Antivral Coatings for Fabrics Used for Personal P
    JOSEF STEPHAN SCHNEIDER; Fiscal Year: 2011
    ..wear personal protective equipment (PPE) such as a respirator masks to minimize contact transmission onto facial skin or airborne inhalation of pathogenic organisms...
  56. Moffitt Skin Cancer SPORE
    Jeffrey S Weber; Fiscal Year: 2013
    ..47 SPECIAL EMPHASIS PANEL ROSTER DESCRIPTION (provided by applicant): The long-range goal of the Moffitt Skin SPORE is to promote progress in the prevention and treatment of cutaneous malignancies based on developments in our ..
  57. Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select Agen
    Arnold Louie; Fiscal Year: 2013
    ..These include a murine model of Gram-negative pneumonia and mouse thigh infection as a surrogate for skin/skin structure infection. This latter model will be run in both neutropenic and normal conditions...
  58. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..of both platelet derived growth factor (PDGF) and its receptors (PDGFR1 and PDGFR2) have been demonstrated in skin of scleroderma patients...
  59. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2011
    ..As is a class I carcinogen known to cause cancers of the skin, bladder, and lung, as well as ischemic heart disease and neurologic impairments...
  60. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..The disease is most commonly restricted to the skin but can also involve the musculoskeletal system and rarely the gastrointestinal tract and the eyes...
  61. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriasis is a chronic inflammatory disease of the skin that affects between 2-3% of Americans...
  62. Improving Patient Safety: Context and Nurses'Work Processes for Pressure Ulcers
    Lynn M Soban; Fiscal Year: 2013
    ..Weaknesses: * In response to the VANOD data VANOD currently collects data about skin assessment and pressure ulcers, and these data are available through VSSC reports...
  63. The Mucolipin TRP Ion Channels
    Haoxing Xu; Fiscal Year: 2013
    ..iron staining methods, we will determine whether iron release from endo-lysosomes is impaired in TRPML1-deficient skin fibroblasts...
  64. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Epidermolysis bullosa (EB) is a group of rare inherited skin blistering diseases that result in severe blistering and scaring...
  65. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..of this proposal is to gain insight into mechanisms of cutaneous host defense against the common bacterial skin pathogen Staphylococcus aureus. S...
  66. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    The incidence of skin cancer has been on the rise in recent years and as in most cancers, early diagnosis and thorough treatment (i.e., complete resection) are the keys to gain a favorable prognosis...
  67. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..Over 350 rare monogenic disorders cause disease in the skin, and common inflammatory diseases affecting several percent of the population, such as psoriasis, have well-..
  68. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..OCA2 results in hypopigmentation of the skin, hair and eyes as well as visual deficits resulting from misrouting of the optic tract and maldevelopment of the ..
  69. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fairness of skin correlates with diminished epidermal expression of eumelanin, the brown/black pigment responsible for dark complexion...
  70. Raising Literacy and Capacity for Incontinence and Skin Care in Dementia
    Donna Bliss; Fiscal Year: 2009
    ..e., incontinence) occurs as Alzheimer's disease or dementia (AD) progresses. Skin damage, in the form of perineal dermatitis and pressure ulcers, is the most frequent physical consequence of ..
  71. Automatic Detection of Critical Dermoscopy Features for Basal Cell Carcinoma
    William V Stoecker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): SkinScan digital dermoscopy skin cancer detection software, developed by Missouri's S&A, can now detect critical features of early melanoma...
  72. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2010
    ..While irritants may cause overt damage to the skin, both types of dermatitis produce very similar inflammatory responses...
  73. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Transplantation of tissue-engineered skin grafts has delivered new medical benefits to patients with acute skin wounds arising from extensive, full-thickness burns, but applications of these devices ..
  74. Venous Ulcers: Testing Effects of Compression & Position
    Deidre Wipke Tevis; Fiscal Year: 2005
    Chronic venous insufficiency causes changes in the skin microcirculation that result in hypoxia, impaired blood flow, edema, and painful venous ulcers. Nursing management of these ulcers is an ongoing challenge...
  75. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    The skin is both target and source for proopiomelanocortin (POMC)-derived neuropeptides...
  76. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    Loss of skin barrier function can dramatically increase morbidity and mortality from radiation exposure in a nuclear accident, attack, or terrorist incident...
  77. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human skin, like all other organs, undergoes alterations as a consequence of aging...
  78. Protein Kinase D and Epidermal Structure and Function
    Wendy B Bollag; Fiscal Year: 2010
    The non-melanoma skin cancers (NMSCs), basal and squamous cell carcinoma are the most common cancers, with approximately 1 million new cases diagnosed per year...
  79. CELLULAR & MOLECULAR BASIS FOR BASAL CELL NEVUS SYNDROME
    HONNAVARA ANANTHASWAMY; Fiscal Year: 1992
    ..objective of this proposal is to investigate the cellular and molecular basis for the genetic predisposition to skin cancer of individuals with BCNS...
  80. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Our goal is to develop an in vitro experimental model to study skin tissue changes that lead to impaired healing and pressure ulcers in elderly...