skin

Summary

Summary: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Top Publications

  1. pmc Topographical and temporal diversity of the human skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Science 324:1190-2. 2009
  2. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
  3. ncbi Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
  4. ncbi Pathogenesis and therapy of psoriasis
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA
    Nature 445:866-73. 2007
  5. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
  6. pmc Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
    Jun Ding
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Am J Hum Genet 87:779-89. 2010
  7. doi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
  8. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
  9. pmc Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin
    Rachel M Schowalter
    Tumor Virus Molecular Biology Section, Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Cell Host Microbe 7:509-15. 2010
  10. pmc The skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4442, USA
    Nat Rev Microbiol 9:244-53. 2011

Detail Information

Publications302 found, 100 shown here

  1. pmc Topographical and temporal diversity of the human skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Science 324:1190-2. 2009
    Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease...
  2. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
    The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages...
  3. ncbi Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
    ..It is well described at the histological level, but the genes that regulate skin repair have only partially been identified...
  4. ncbi Pathogenesis and therapy of psoriasis
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA
    Nature 445:866-73. 2007
    Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings...
  5. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
    ..Here we show that the persistence of Leishmania major in the skin after healing in resistant C57BL/6 mice is controlled by an endogenous population of CD4+CD25+ regulatory T cells...
  6. pmc Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
    Jun Ding
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Am J Hum Genet 87:779-89. 2010
    Psoriasis, an immune-mediated, inflammatory disease of the skin and joints, provides an ideal system for expression quantitative trait locus (eQTL) analysis, because it has a strong genetic basis and disease-relevant tissue (skin) is ..
  7. doi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation...
  8. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..Thus, our data suggest that BM-MSCs promote wound healing through differentiation and release of proangiogenic factors. Disclosure of potential conflicts of interest is found at the end of this article...
  9. pmc Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin
    Rachel M Schowalter
    Tumor Virus Molecular Biology Section, Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Cell Host Microbe 7:509-15. 2010
    ..polyomavirus (MCV), a circular double-stranded DNA virus, is a causal factor underlying a highly lethal form of skin cancer known as Merkel cell carcinoma...
  10. pmc The skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4442, USA
    Nat Rev Microbiol 9:244-53. 2011
    The skin is the human body's largest organ, colonized by a diverse milieu of microorganisms, most of which are harmless or even beneficial to their host...
  11. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008
    ..Our results suggest that factors released by BM-MSCs recruit macrophages and endothelial lineage cells into the wound thus enhancing wound healing...
  12. pmc Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model
    Adam D Kennedy
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Infect Dis 202:1050-8. 2010
    ..methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are predominantly those affecting skin and soft tissues...
  13. pmc Asymmetric cell divisions promote stratification and differentiation of mammalian skin
    Terry Lechler
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 437:275-80. 2005
    ..We further demonstrate that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3-LGN-Inscuteable complex and NuMA-dynactin to align the spindle...
  14. ncbi Controls of hair follicle cycling
    K S Stenn
    Beauty Genome Sciences Inc, Skillman, New Jersey, USA
    Physiol Rev 81:449-494. 2001
    ..For the immediate future, our challenge is to define the molecular basis for hair follicle growth control, to regenerate a mature hair follicle in vitro from defined populations, and to offer real solutions to our patients' problems...
  15. pmc IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and Maternal Fetal Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:4448-53. 2010
    ..is significantly increased in affected and unaffected (at least 15 cm away from the lesion) psoriatic skin, as compared with normal control skin...
  16. ncbi Isolation and characterization of multipotent skin-derived precursors from human skin
    Jean G Toma
    Department of Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Stem Cells 23:727-37. 2005
    We have previously isolated, expanded, and characterized a multipotent precursor cell from mammalian dermis (termed skin-derived precursors [SKPs]) that can differentiate into both neural and mesodermal progeny...
  17. ncbi Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
    ..TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation...
  18. ncbi Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Tissue Eng 13:1299-312. 2007
    ..A single bone marrow aspirate of 35-50 mL was obtained from patients with acute wounds (n = 5) from skin cancer surgery and from patients with chronic, long-standing, nonhealing lower extremity wounds (n = 8)...
  19. ncbi Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins...
  20. doi Macrophages in skin injury and repair
    Babak Mahdavian Delavary
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 216:753-62. 2011
    ..This review summarizes macrophage function in skin injury repair, thereby providing more insight in macrophage function in wound healing and possible interventions in ..
  21. pmc Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America
    L Berger
    School of Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4811, Australia
    Proc Natl Acad Sci U S A 95:9031-6. 1998
    ..Experimental data support the conclusion that cutaneous chytridiomycosis is a fatal disease of anurans, and we hypothesize that it is the proximate cause of these recent amphibian declines...
  22. pmc Skin microbiome: genomics-based insights into the diversity and role of skin microbes
    Heidi H Kong
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Drive, Bldg 10, Rm 12N238, Bethesda, MD 20892, USA
    Trends Mol Med 17:320-8. 2011
    Recent advances in DNA sequencing methodology have facilitated studies of human skin microbes that circumvent difficulties in isolating and characterizing fastidious microbes...
  23. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008
    Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs...
  24. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ..release IL-10 or interferon (IFN)-gamma, and were found to accumulate in chronic sites of infection, including the skin and draining lymph node. A high frequency of the dermal CD4+ T cells released both IL-10 and IFN-gamma...
  25. doi Atopic dermatitis
    Thomas Bieber
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    N Engl J Med 358:1483-94. 2008
  26. pmc Skin immune sentinels in health and disease
    Frank O Nestle
    St John s Institute of Dermatology, King s College London, UK
    Nat Rev Immunol 9:679-91. 2009
    Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome...
  27. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..Here we show in mice that localized vaccinia virus (VACV) skin infection generates long-lived non-recirculating CD8(+) skin T(RM) cells that reside within the entire skin...
  28. doi Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Thomas Gebhardt
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia
    Nat Immunol 10:524-30. 2009
    ..a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia...
  29. pmc Induced pluripotent stem cells from a spinal muscular atrophy patient
    Allison D Ebert
    The Waisman Center, The Stem Cell and Regenerative Medicine Center, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Nature 457:277-80. 2009
    ..Here we report the generation of induced pluripotent stem cells from skin fibroblast samples taken from a child with spinal muscular atrophy...
  30. pmc Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
    M Zasloff
    Proc Natl Acad Sci U S A 84:5449-53. 1987
    A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis...
  31. pmc Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling
    Eric Festa
    Department of Molecular Biology, Yale University, 219 Prospect St, New Haven, CT 06520, USA
    Cell 146:761-71. 2011
    In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration...
  32. pmc Epidermal homeostasis: a balancing act of stem cells in the skin
    Cedric Blanpain
    Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Nat Rev Mol Cell Biol 10:207-17. 2009
    The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis...
  33. doi Multilineage differentiation potential of human dermal skin-derived fibroblasts
    Katrin Lorenz
    Department of Cell Techniques and Applied Stem Cell Biology, Biotechnological Biomedical Center, University of Leipzig, Leipzig, Germany
    Exp Dermatol 17:925-32. 2008
    Dermal skin-derived fibroblasts from rodent and human have been found to exhibit mesenchymal surface antigen immunophenotype and differentiation potential along the three main mesenchymal-derived tissues: bone, cartilage and fat...
  34. pmc Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility
    K G Danielson
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 136:729-43. 1997
    ..We report that mice harboring a targeted disruption of the decorin gene are viable but have fragile skin with markedly reduced tensile strength...
  35. pmc RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
    Ben Jackson
    Biomedical Institute, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark
    Mol Biol Cell 22:593-605. 2011
    ..In skin, loss of RhoA was suggested to underlie pemphigus skin blistering...
  36. doi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
    b>Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens...
  37. pmc Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, and Bethesda, Maryland, USA
    J Infect Dis 204:937-41. 2011
    ..The role of PVL in the success of the epidemic CA-MRSA strain USA300 remains unknown. Here we developed a skin and soft tissue infection model in rabbits to test the hypothesis that PVL contributes to USA300 pathogenesis and ..
  38. ncbi Mechanisms of photoaging and chronological skin aging
    Gary J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Dermatol 138:1462-70. 2002
    Human skin, like all other organs, undergoes chronological aging. In addition, unlike other organs, skin is in direct contact with the environment and therefore undergoes aging as a consequence of environmental damage...
  39. ncbi Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
    We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle ..
  40. pmc p63 is the molecular switch for initiation of an epithelial stratification program
    Maranke I Koster
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 18:126-31. 2004
    ..Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis...
  41. ncbi Inflammation in wound repair: molecular and cellular mechanisms
    Sabine A Eming
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:514-25. 2007
    ..In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response...
  42. pmc Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons
    Liang Qiang
    Departments of Pathology, Cell Biology, and Neurology and Taub Institute, Columbia University, New York, NY 10032, USA
    Cell 146:359-71. 2011
    ..Here, we describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators ..
  43. pmc Compartmentalized control of skin immunity by resident commensals
    Shruti Naik
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 337:1115-9. 2012
    ..We found that in mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte ..
  44. pmc Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Immunity 37:60-73. 2012
    ..Cutaneous CD141(hi) DCs were closely related to blood CD141(+) DCs, and migratory counterparts were found among skin-draining lymph node DCs...
  45. pmc Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
    Heidi H Kong
    Dermatology Branch, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Genome Res 22:850-9. 2012
    Atopic dermatitis (AD) has long been associated with Staphylococcus aureus skin colonization or infection and is typically managed with regimens that include antimicrobial therapies...
  46. pmc The ability of the skin to absorb heat; the effect of repeated exposure and age
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA
    Med Sci Monit 17:CR1-8. 2011
    When heat is applied to the skin, it is dissipated due to conductive heat flow in the tissue and the blood...
  47. doi Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation
    Rieneke van de Ven
    Departments of Medical Oncology, VU University Medical Center Cancer Center Amsterdam, De Boelelaan, Amsterdam, The Netherlands
    Blood 118:2502-10. 2011
    ..In this study we identified and functionally tested 4 human conventional DC (cDC) subsets within skin-draining sentinel lymph nodes (SLNs) from early-stage melanoma patients...
  48. ncbi A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs
    Zhang Wenguang
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Nei Mongol Autonomous Region, Hohhot, PR China
    OMICS 11:385-96. 2007
    ..miRNAs that might function in hair growth, we characterized the expression of 159 miRNAs in adult body side skin and ear skin from goat and sheep using microarray analysis...
  49. pmc Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
    Cory L Simpson
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 12:565-80. 2011
    ..These architectural components are more than just rivets and scaffolds - they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation...
  50. pmc Hair follicle stem cells are specified and function in early skin morphogenesis
    Jonathan A Nowak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 3:33-43. 2008
    In adult skin, epithelial hair follicle stem cells (SCs) reside in a quiescent niche and are essential for cyclic bouts of hair growth. Niche architecture becomes pronounced postnatally at the start of the first hair cycle...
  51. ncbi Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis
    Kenneth R Feingold
    Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 48:2531-46. 2007
    ..Topical application of physiologic lipids can improve permeability barrier homeostasis and has been useful in the treatment of cutaneous disorders...
  52. ncbi Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin
    Igor Adameyko
    Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    Cell 139:366-79. 2009
    ..crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin. Here, we identify growing nerves projecting throughout the body as a stem/progenitor niche containing Schwann cell ..
  53. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    Atopic dermatitis is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and is often the first step in the atopic march that results in asthma and allergic rhinitis...
  54. ncbi Perp is a p63-regulated gene essential for epithelial integrity
    Rebecca A Ihrie
    Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell 120:843-56. 2005
    ..important for tissue integrity, and numerous structural defects in desmosomes are observed in Perp-deficient skin, suggesting a role for Perp in promoting the stable assembly of desmosomal adhesive complexes...
  55. ncbi Strain-dependent epithelial defects in mice lacking the EGF receptor
    M Sibilia
    Institute of Molecular Pathology IMP, Vienna, Austria
    Science 269:234-8. 1995
    ..These results indicate that the EGFR regulates epithelial proliferation and differentiation and that the genetic background influences the resulting phenotype...
  56. doi Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
    J M Jungersted
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
    Allergy 65:911-8. 2010
    Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic dermatitis (AD) has been documented, and changes in ceramide profile, altered skin pH and increased trans-epidermal water loss (TEWL) in ..
  57. ncbi Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type
    Mikako Sasaki
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7 Kita ku, Sapporo, Japan
    J Immunol 180:2581-7. 2008
    ..In this study, we assessed whether MSCs can differentiate into multiple skin cell types including keratinocytes and contribute to wound repair...
  58. pmc Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    Fadi Issa
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Transplantation 90:1321-7. 2010
    ..most complex defects, but its use is limited because of harmful immunosuppression and the high susceptibility of skin to rejection...
  59. pmc Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    Edmund Lee
    Laboratory for Investigative Dermatology, The Rockefeller University Hospital, P O Box 178, 1230 York Avenue, New York, NY 10021, USA
    J Exp Med 199:125-30. 2004
    ..a role in the recruitment of inflammatory cells in a T helper cell (Th)1-mediated disease, we examined psoriasis skin lesions for production of this newly described cytokine...
  60. ncbi Pathophysiology of acute wound healing
    Jie Li
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin Dermatol 25:9-18. 2007
    ..healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a ..
  61. pmc Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
    Demeng Chen
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1522-33. 2012
    Dermal fibroblasts are required for structural integrity of the skin and for hair follicle development...
  62. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    ..These observations suggest a potential therapeutic approach for healing wounds in diabetic patients...
  63. pmc Type I interferon: potential therapeutic target for psoriasis?
    Yihong Yao
    MedImmune, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 3:e2737. 2008
    ..To better understand the pathogenesis of this disease and identify potential mediators, we used whole genome array analysis to profile paired lesional and nonlesional psoriatic skin and skin from healthy donors.
  64. ncbi Molecular mechanisms regulating hair follicle development
    Sarah E Millar
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 118:216-25. 2002
    ..The importance of the hair follicle in skin biology, however, does not rest solely with its ability to produce hair...
  65. doi Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis
    M Nermes
    Department of Pediatrics, Turku University Central Hospital, Turku, Finland
    Clin Exp Allergy 41:370-7. 2011
    ..The maturational events in the gut parallel its step-wise colonization. Atopic dermatitis (AD) is associated with aberrant barrier functions of the skin epithelium and, in a subgroup of patients, of the gut mucosa.
  66. doi Ceramide biosynthesis in keratinocyte and its role in skin function
    Yukiko Mizutani
    Hokkaido University, Kita jo, Nishi choume, Kita ku, Sapporo, Japan
    Biochimie 91:784-90. 2009
    ..In addition, we provide experimental information, including our recent findings, as to how applying ceramide or ceramide-containing substances to skin, orally or directly, can benefit skin health.
  67. pmc Forensic identification using skin bacterial communities
    Noah Fierer
    Department of Ecology and Evolutionary Biology, Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 107:6477-81. 2010
    Recent work has demonstrated that the diversity of skin-associated bacterial communities is far higher than previously recognized, with a high degree of interindividual variability in the composition of bacterial communities...
  68. pmc Filaggrin in the frontline: role in skin barrier function and disease
    Aileen Sandilands
    Epithelial Genetics Group, Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry and Nursing, University of Dundee, Dundee DD1 5EH, UK
    J Cell Sci 122:1285-94. 2009
    ..in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (which is characterised by dry, scaly skin)...
  69. doi Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    Matthias Schmuth
    Department of Dermatology, University of California, San Francisco, CA, USA
    J Lipid Res 49:499-509. 2008
    ..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, ..
  70. pmc Aging and chronic sun exposure cause distinct epigenetic changes in human skin
    Elke Grönniger
    Research and Development, Beiersdorf AG, Hamburg, Germany
    PLoS Genet 6:e1000971. 2010
    ..We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation...
  71. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010
    ..Second, a severe skin permeability barrier defect uncovers an essential ATGL-independent role of CGI-58 in skin lipid metabolism...
  72. ncbi Lung/skin connections in occupational lung disease
    Carrie A Redlich
    Occupational and Environmental Medicine and Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Allergy Clin Immunol 8:115-9. 2008
    ..Research and prevention have focused primarily on the respiratory tract. Recent studies, however, suggest that the skin may also be an important route of exposure and site of sensitization...
  73. ncbi Delayed wound healing in immunodeficient TGF-beta 1 knockout mice
    M J Crowe
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Invest Dermatol 115:3-11. 2000
    ....
  74. pmc MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing
    Noriko Hattori
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    Am J Pathol 175:533-46. 2009
    ..These data suggest that MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in wound healing, while MMP-9 functions in keratinocyte migration...
  75. ncbi Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
    Y Zheng
    Johnson and Johnson Skin Biology TRC, Grandview Road, Skillman, New Jersey 08558, USA
    Genomics 71:182-91. 2001
    ..identification and characterization of a novel member of this family, Scd3, whose expression is restricted to mouse skin, specifically to the sebaceous gland. The Scd3 gene codes for a transcript of approximately 4...
  76. pmc Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 18:8220-8. 2010
    ..we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e...
  77. doi Transfer of bisphenol A from thermal printer paper to the skin
    Sandra Biedermann
    Official Food Control Authority of the Canton of Zurich, P O Box 1471, CH 8032, Zurich, Switzerland
    Anal Bioanal Chem 398:571-6. 2010
    ..2-6 microg) was transferred to the forefinger and the middle finger if the skin was rather dry and about ten times more if these fingers were wet or very greasy...
  78. ncbi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    M Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, 53706, USA
    J Nutr 131:2260-8. 2001
    ..To investigate the physiologic functions of SCD1, we generated SCD1 null (SCD1-/-) mice. The skin and eyelid of SCD1-/- mice are deficient in triglycerides and cholesterol esters, and the eyelid also is deficient ..
  79. ncbi Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders
    Magdalena Lebiedzinska
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Biochim Biophys Acta 1797:952-60. 2010
    ..This suggest that SOD2 is under control of the Ser36 phosphorylation status of p66Shc protein. As a consequence, an intracellular oxidative stress and accumulation of damages caused by oxygen free radicals are observed in the cells...
  80. doi ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
    William M Keyes
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell Stem Cell 8:164-76. 2011
    ..tumor-suppressive mechanism of cellular senescence, causing a striking absence of stratified epithelia such as the skin. Here we identify the predominant p63 isoform, ΔNp63α, as a protein that bypasses oncogene-induced senescence to ..
  81. doi CCN2 is required for bleomycin-induced skin fibrosis in mice
    Shangxi Liu
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 63:239-46. 2011
    ..The aim of this study was to assess whether adult mice bearing a smooth muscle cell/fibroblast-specific deletion of CCN2 are resistant to bleomycin-induced skin scleroderma.
  82. doi MicroRNAs: novel regulators in skin inflammation
    E Sonkoly
    Molecular Dermatology Research Group, Unit of Dermatology and Venereology, Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Clin Exp Dermatol 33:312-5. 2008
    ..in the pathogenesis of psoriasis and atopic eczema (AE), the two most common chronic inflammatory disorders in skin. In particular, miR-203, the first skin-specific miRNA, showing an intriguing expression profile being confined to ..
  83. pmc Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions
    L Farkas
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 159:237-43. 2001
    ..results showed that P-DCs were present in 14 out of 15 tissue specimens of cutaneous LE lesions, but not in normal skin. Importantly, the density of P-DCs in affected skin correlated well (r(s) = 0.79,P < 0...
  84. doi Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients
    Ignacio Blanco
    Department of Internal Medicine, Valle del Nalon Hospital, 33920 Langreo, Principado de Asturias, Spain
    Clin Rheumatol 29:1403-12. 2010
    Formalin-fixed, paraffin-embedded skin tissue sections were collected from a matched cohort of 63 fibromyalgia syndrome (FMS) patients and 49 volunteers from the general population with both alpha1-antitrypsin (AAT) normal and deficiency ..
  85. pmc TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation
    Xiping Cheng
    The Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, 3089 Natural Science Building Kraus, 830 North University, Ann Arbor, MI 48109, USA
    Cell 141:331-43. 2010
    ..of growth factors regulate keratinocyte proliferation and differentiation that control hair morphogenesis and skin barrier formation...
  86. doi Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 115:1958-68. 2010
    ..RA-producing DCs were primarily of the tissue-derived, migratory DC subtype and can be readily found in the skin and in the lungs as well as in their corresponding draining lymph nodes...
  87. pmc Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2
    Chunli Yan
    Department of Surgery, The Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Pathol 176:2247-58. 2010
    ..Whether and how EMT occurs in wound healing and fibrosis in human skin remains unknown...
  88. pmc Varicella-zoster virus T cell tropism and the pathogenesis of skin infection
    Ann M Arvin
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    Curr Top Microbiol Immunol 342:189-209. 2010
    ..to the pathogenesis of primary VZV infection, we have examined VZV infection of human T cell (thymus/liver) and skin xenografts...
  89. ncbi Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitis
    Georg Dimcevski
    Department of Medical Gastroenterology, Haukeland University Hospital, Bergen, Norway
    Pancreas 35:22-9. 2007
    ..We, therefore, aimed at exploring the pain mechanisms in chronic pancreatitis (CP) using a multimodal and multitissue stimulation approach...
  90. ncbi Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury
    Jeff Biernaskie
    Developmental and Stem Cell Biology Group, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7
    J Neurosci 27:9545-59. 2007
    ..Here, we asked whether skin-derived precursors (SKPs), a neural crest-like precursor that can be isolated and expanded from mammalian skin, ..
  91. doi Clinical administration of microneedles: skin puncture, pain and sensation
    M I Haq
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Biomed Microdevices 11:35-47. 2009
    ..facilitate drug delivery without significantly impacting on pain receptors or blood vessels that reside beneath the skin outer layers...
  92. doi A skin microRNA promotes differentiation by repressing 'stemness'
    Rui Yi
    Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10065, USA
    Nature 452:225-9. 2008
    ..Here, we show that microRNA-203 is induced in the skin concomitantly with stratification and differentiation...
  93. ncbi Attenuated skin blood flow response to nociceptive stimulation of latent myofascial trigger points
    Yang Zhang
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Arch Phys Med Rehabil 90:325-32. 2009
    To investigate the effect of painful stimulation of latent myofascial trigger points (MTrPs) on skin blood flow and to evaluate the relative sensitivity of laser Doppler flowmetry (LDF) and thermography in the measurement of skin blood ..
  94. ncbi Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner
    Masaru Tamura
    Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 0845, Japan
    Genomics 89:618-29. 2007
    Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants...
  95. doi Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
    Alfiya Akhmetshina
    Department of Internal Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 60:219-24. 2009
    ....
  96. doi Liposomes and skin: from drug delivery to model membranes
    G M El Maghraby
    College of Pharmacy, King Saud University, Riyadh 11451, P O Box 2457, Saudi Arabia
    Eur J Pharm Sci 34:203-22. 2008
    The early eighties saw the introduction of liposomes as skin drug delivery systems, initially promoted primarily for localised effects with minimal systemic delivery...
  97. ncbi The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells?
    Robin E Callard
    Immunobiology Unit, Institute of Child Health, University College London, London, UK, WC1N 1EH
    Trends Immunol 28:294-8. 2007
    The skin barrier (stratum corneum) is a major factor for determining the nature of immune response to antigens presented at the skin surface...
  98. doi Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis
    J H W Distler
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Germany
    Rheumatology (Oxford) 47:v10-1. 2008
    ..matrix protein in human dermal fibroblasts in vitro and prevented fibrosis in the mouse model of bleomycin-induced skin fibrosis...
  99. pmc Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    Peter M Elias
    Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco, 94121, USA
    Curr Opin Allergy Clin Immunol 9:437-46. 2009
    ..We will review here emerging evidence that the inflammation in atopic dermatitis results from inherited and acquired insults to the barrier and the therapeutic implications of this new paradigm...
  100. ncbi Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases
    Gillian Smith
    Biomedical Research Centre, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK
    Lancet 361:1336-43. 2003
    Treatment of common skin diseases such as psoriasis is complicated by differences between individuals in response to topical drug treatment and photochemotherapy...
  101. ncbi Immunization with DNA through the skin
    Kristina K Peachman
    Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 2A24, Silver Spring, MD 20910 7500, USA
    Methods 31:232-42. 2003
    The skin has evolved as a barrier to prevent external agents, including pathogens, from entering the body. It has a complex and efficient immune surveillance system, which includes Langerhans cells and dendritic cells...

Research Grants149 found, 100 shown here

  1. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASES
    Donald Leung; Fiscal Year: 1993
    Atopic dermatitis (AD) and psoriasis are common chronic inflammatory skin diseases associated with significant morbidity and occupational disability...
  2. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 1999
    Atopic dermatitis (AD) and psoriasis are common chronic inflammatory skin diseases associated with significant morbidity and occupational disability. Colonization and infection with S...
  3. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ..is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles ..
  4. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Adult participants may also provide a skin sample. - Tissue or fluid from eye collected as part of eye care or treatment may also be added to the database...
  5. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Adult participants may also provide a skin sample. - Tissue or fluid from eye collected as part of eye care or treatment may also be added to the database...
  6. Tissue Culture Laboratory
    Joseph Goldstein; Fiscal Year: 2009
    ..Since 1973, over 1000 different primary human fibroblast cell strains, derived from skin biopsies from normal subjects as well as from patients with metabolic disorders, have been initiated in our ..
  7. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..The LLNA was subsequently incorporated into national and international test guidelines for the assessment of skin sensitization. Accidental eye injury is a leading cause of visual impairment in the U.S...
  8. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..The LLNA was subsequently incorporated into national and international test guidelines for the assessment of skin sensitization. Accidental eye injury is a leading cause of visual impairment in the U.S...
  9. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2013
    ..on molecular target(s) in tumors;identification of normal tissue that is a surrogate for tumor, if possible (PBMCs, skin, saliva, buccal mucosa, etc);development and validation of clinically-transferable, SOP-driven procedures for ..
  10. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2009
    ..on molecular target(s) in tumors;identification of normal tissue that is a surrogate for tumor, if possible (PBMCs, skin, saliva, buccal mucosa, etc);development and validation of clinically-transferable, SOP-driven procedures for ..
  11. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2011
    ..on molecular target(s) in tumors;identification of normal tissue that is a surrogate for tumor, if possible (PBMCs, skin, saliva, buccal mucosa, etc);development and validation of clinically-transferable, SOP-driven procedures for ..
  12. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2010
    ..on molecular target(s) in tumors;identification of normal tissue that is a surrogate for tumor, if possible (PBMCs, skin, saliva, buccal mucosa, etc);development and validation of clinically-transferable, SOP-driven procedures for ..
  13. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2012
    ..on molecular target(s) in tumors;identification of normal tissue that is a surrogate for tumor, if possible (PBMCs, skin, saliva, buccal mucosa, etc);development and validation of clinically-transferable, SOP-driven procedures for ..
  14. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2009
    ..An association between clinical symptoms (diarrhea, weight loss, skin lesions, etc...
  15. Stilbene's Contribution in Hemorrhagic Stroke
    SYLVAIN DORE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The stilbene compound resveratrol is naturally present in grape skin and seeds and is found in particularly high concentrations in red wine...
  16. Stilbene's Contribution in Hemorrhagic Stroke
    SYLVAIN DORE; Fiscal Year: 2010
    The stilbene compound resveratrol is naturally present in grape skin and seeds and is found in particularly high concentrations in red wine...
  17. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..extensive studies of transgenic mice and human tissues, we have identified galectin-3 as a key molecule involved in skin inflammation. We have begun to characterize drugs targeting galectin-3 for treatment of eczema...
  18. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..b>Skin grafting between two genetically distinct mouse strains will be used to test the ability of the ex vivo IL-10 gene ..
  19. ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESIS
    ENRIQUE A contact MESRI; Fiscal Year: 2010
    ..The tumor is characterized by intense angiogenesis and the proliferation of spindle cells that can affect the skin, mucosa and viscera, causing significant morbidity...
  20. ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESIS
    Enrique A Mesri; Fiscal Year: 2013
    ..The tumor is characterized by intense angiogenesis and the proliferation of spindle cells that can affect the skin, mucosa and viscera, causing significant morbidity...
  21. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..Biomarkers that respond to CR and certain mADF regimens include global cell proliferation (mammary, prostate, skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin sensitivity, and vascular smooth muscle ..
  22. Cellular & Inflammatory Pathways in Ashtma & Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2010
    ..expression of CD88;discovering the activating form of FcyRII, CD32a, constitutively expressed on the surface of skin MCTC cells;and finding Syk-deficiency in basophils with the non-releaser phenotype and in mast cells after antigen ..
  23. Cellular & Inflammatory Pathways in Ashtma & Allergic Diseases: From IgE to Cells
    Lawrence Schwartz; Fiscal Year: 2009
    ..expression of CD88;discovering the activating form of FcyRII, CD32a, constitutively expressed on the surface of skin MCTC cells;and finding Syk-deficiency in basophils with the non-releaser phenotype and in mast cells after antigen ..
  24. NF Center: from animal models to therapeutics
    Luis F Parada; Fiscal Year: 2010
    ..2, we will expand on our recent development of a murine model for dermal neurofibromas and on the discovery that skin-derived precursors (SKPs) are the cell of origin for these tumors...
  25. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..While acne vulgaris is the most prevalent skin disorder in humans, the other diseases are also relatively common...
  26. Induced Pluripotent Stem Cells in Canine Muscular Dystrophy
    Martin K Childers; Fiscal Year: 2010
    ..that it is possible to generate induced pluripotent stem (iPS) cells from easily obtained cells such as skin fibroblasts or keratinocytes, by relatively simple reprogramming steps, constitutes a major scientific advance with ..
  27. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..pharyngitis, an infection state commonly referred to as 'strep throat', but it is also implicated in skin and soft tissue infections, as well as life threatening invasive disease and the post-streptococcal autoimmune ..
  28. Single Cell Genomics of Human Microbial Flora
    ROGER SENDER LASKEN; Fiscal Year: 2010
    ..Isolation from the characteristic Lyme disease rash in human skin is planned next and ultimately from human brain tissue where it is suspected of causing neurological symptoms...
  29. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..Dermal Toxicity Testing The evaluation and development of alternatives for dermal (skin) safety testing is also one of ICCVAM's four highest priorities because it is required by multiple agencies as ..
  30. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..with generation of INrf2 conditional knockout mice that do not express INrf2 protein in liver and epidermis of skin. The Cre-Lox system will be used to generate these mice...
  31. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..We will identify peripheral blood cell and skin gene expression patterns that can predict the course of ILD...
  32. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and
  33. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2012
    ..to DNA damage, defects in DNA repair and cell cycle checkpoints, as well as lead to the development of cataracts or skin cancer. Therefore, it is important to understand mechanisms that regulate RAD9 levels...
  34. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..who are not breastfed suffer increased health problems such as ear infections, lower respiratory tract infections, skin rashes similar to eczema, asthmatic episodes, type I and type II diabetes, episodes of infant diarrhea, and ..
  35. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..environmental carcinogen and that repeated exposures can lead to the development of melanoma and nonmelanoma skin cancers...
  36. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2011
    ..AIM 2: Determine the optimal physico-chemical properties of NPSs for skin penetration and LC activation, and the mechanisms underlying OVA-specific immune induction by NPS...
  37. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..AIM 2: Determine the optimal physico-chemical properties of NPSs for skin penetration and LC activation, and the mechanisms underlying OVA-specific immune induction by NPS...
  38. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..In preliminary studies, to develop human models of TS, I reprogrammed human skin cells from two TS patients to generate induced pluripotent stem cells (iPSCs) and differentiated these cells into ..
  39. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..In preliminary studies, to develop human models of TS, I reprogrammed human skin cells from two TS patients to generate induced pluripotent stem cells (iPSCs) and differentiated these cells into ..
  40. Varicella zoster virus: molecular controls of cell fusion-dependent pathogenesis
    Ann Arvin; Fiscal Year: 2012
    ..Varicella can be serious and is life-threatening in immunocompromised patients. VZV exhibits tropism for T cells, skin and neurons during infection of the human host and overcomes the usual constraint against fusion between fully ..
  41. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2010
    ..HIV through primary human genital epithelial cells;v) blocks infection of dendritic and Langerhans cells ex vivo (skin tissues);vi) prevents HIV transfer from dendritic and Langerhans cells to T cells ex vivo;vii) is extremely ..
  42. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..spices, condiments, liquids (water, wine, coffee beer, tea) and all materials placed on the subject/patient's skin such as: lotions, perfumes, cosmetics (lipstick, makeup), soaps, shampoos, deodorant, etc...
  43. Molecular Assays for epidemiology studies
    LARRY ARTHUR; Fiscal Year: 2009
    ..Myeloma Non-Hodgkin Lymphoma Pancreatic cancer Pharyngeal cancer Prostate cancer Oral cancer Ovarian cancer Skin cancer Stomach cancer Testicluar cancer Thyroid cancer Uterine cancer Urologic disorders Vaginal cancer
  44. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    SIBA RAYCHAUDHURI; Fiscal Year: 2009
    ..will investigate whether injection of NGF and NGF activated autologus T lymphocytes induce psoriasis in nonlesional skin transplant in the SCID mouse-human skin xenograft model...
  45. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..of this proposal is to gain insight into mechanisms of cutaneous host defense against the common bacterial skin pathogen Staphylococcus aureus. S...
  46. Host defense against Staphylococcus aureus skin infections
    Lloyd Miller; Fiscal Year: 2009
    ..of this proposal is to gain insight into mechanisms of cutaneous host defense against the common bacterial skin pathogen Staphylococcus aureus. S...
  47. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    The incidence of skin cancer has been on the rise in recent years and as in most cancers, early diagnosis and thorough treatment (i.e., complete resection) are the keys to gain a favorable prognosis...
  48. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2007
    There is a fundamental gap in our understanding of why skin diseases, such as chronic urticaria and psoriasis, are aggravated by stress. The long-term goal of this research is to define the role of mast cells in inflammatory diseases...
  49. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis C Theoharides; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is a fundamental gap in our understanding of why skin diseases, such as chronic urticaria and psoriasis, are aggravated by stress...
  50. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): There is a fundamental gap in our understanding of why skin diseases, such as chronic urticaria and psoriasis, are aggravated by stress...
  51. Delivery of biologically active nucleic acids to epidermal cells
    ROGER KASPAR; Fiscal Year: 2009
    ..Over 350 rare monogenic disorders cause disease in the skin, and common inflammatory diseases affecting several percent of the population, such as psoriasis, have well-..
  52. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..Over 350 rare monogenic disorders cause disease in the skin, and common inflammatory diseases affecting several percent of the population, such as psoriasis, have well-..
  53. ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASES
    Donald Leung; Fiscal Year: 1992
    Atopic dermatitis (AD) and psoriasis are common chronic inflammatory skin diseases associated with significant morbidity and occupational disability...
  54. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..OCA2 results in hypopigmentation of the skin, hair and eyes as well as visual deficits resulting from misrouting of the optic tract and maldevelopment of the ..
  55. A reconstructed skin model for development of treatments for albinism
    Seth Orlow; Fiscal Year: 2009
    ..OCA2 results in hypopigmentation of the skin, hair and eyes as well as visual deficits resulting from misrouting of the optic tract and maldevelopment of the ..
  56. Use of Substance P antagonists to regulate the skin immune function
    Adriana Larregina; Fiscal Year: 2009
    Recurrent inflammatory diseases are common skin disorders with high socioeconomic impact...
  57. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2010
    Recurrent inflammatory diseases are common skin disorders with high socioeconomic impact...
  58. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2004
    ..is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles ..
  59. UV-Induced Collagen Reduction--Treating Skin Scleroderma
    Sewon Kang; Fiscal Year: 2001
    ..is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles ..
  60. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2002
    ..is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles ..
  61. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2003
    ..is a progressive, potentially life-threatening disease of the connective tissue that can cause hardening of the skin, and damage to lungs, heart, kidney, and gastrointestinal tract, The disease may also affect blood vessels, muscles ..
  62. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Epidermolysis bullosa (EB) is a group of rare inherited skin blistering diseases that result in severe blistering and scaring...
  63. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fairness of skin correlates with diminished epidermal expression of eumelanin, the brown/black pigment responsible for dark complexion...
  64. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fairness of skin correlates with diminished epidermal expression of eumelanin, the brown/black pigment responsible for dark complexion...
  65. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    George Timothy Bowden; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Skin cancer is the most common malignancy in the world. One out of three new cancers is a skin cancer...
  66. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    George Timothy Bowden; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Skin cancer is the most common malignancy in the world. One out of three new cancers is a skin cancer...
  67. Hair Follicle Neogenesis in Response to Wounding
    George Cotsarelis; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Typically, skin heals with a scar without regenerating its previous normal structure that includes hair follicles and sweat glands. Scarring causes contractures and morbidity...
  68. Raising Literacy and Capacity for Incontinence and Skin Care in Dementia
    Donna Bliss; Fiscal Year: 2009
    ..e., incontinence) occurs as Alzheimer's disease or dementia (AD) progresses. Skin damage, in the form of perineal dermatitis and pressure ulcers, is the most frequent physical consequence of ..
  69. Regulation of TSLP-Mediated Skin Inflammation
    Steven Ziegler; Fiscal Year: 2009
    The skin is a barrier tissue with a large surface area in contact with the external environment and its own microbial flora...
  70. Automatic Detection of Critical Dermoscopy Features for Basal Cell Carcinoma
    William V Stoecker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): SkinScan digital dermoscopy skin cancer detection software, developed by Missouri's S&A, can now detect critical features of early melanoma...
  71. Plexin signalling in melanocyte biology and melanoma progression
    Glynis Scott; Fiscal Year: 2009
    Human melanocytes are neural crest derived cells that perform a unique function in the skin. While they are a minority of the population of the epidermis, they are responsible for the majority of photoprotection of the skin from ..
  72. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2010
    Human melanocytes are neural crest derived cells that perform a unique function in the skin. While they are a minority of the population of the epidermis, they are responsible for the majority of photoprotection of the skin from ..
  73. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE GALLUCCI; Fiscal Year: 2009
    ..While irritants may cause overt damage to the skin, both types of dermatitis produce very similar inflammatory responses...
  74. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2010
    ..While irritants may cause overt damage to the skin, both types of dermatitis produce very similar inflammatory responses...
  75. The Role of bacterial toxins in human skin disease.
    DONALD YM contact LEUNG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is a pruritic chronic inflammatory skin disease associated with significant morbidity and occupational disability affecting 17% of children and nearly 2% of adults in the U.S...
  76. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary J Fisher; Fiscal Year: 2010
    ..applicant): The long-term goal of the proposed research is to understand molecular basis and functional impact of skin connective tissue aging...
  77. Regulation of Extracellular Matrix Homeostatsis in Skin Aging
    Gary Fisher; Fiscal Year: 2009
    ..applicant): The long-term goal of the proposed research is to understand molecular basis and functional impact of skin connective tissue aging...
  78. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2007
    Transplantation of tissue-engineered skin grafts has delivered new medical benefits to patients with acute skin wounds arising from extensive, full-thickness burns, but applications of these devices to elective surgery (i.e...
  79. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Transplantation of tissue-engineered skin grafts has delivered new medical benefits to patients with acute skin wounds arising from extensive, full-thickness burns, but applications of these devices ..