nails

Summary

Summary: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.

Top Publications

  1. ncbi Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
    A Barel
    Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium
    Arch Dermatol Res 297:147-53. 2005
  2. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
  3. ncbi Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water
    Angeline S Andrew
    Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 104:263-8. 2003
  4. pmc A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Environ Health Perspect 113:1669-74. 2005
  5. pmc Associations of toenail selenium levels with inflammatory biomarkers of fibrinogen, high-sensitivity c-reactive protein, and interleukin-6: The CARDIA Trace Element Study
    Pengcheng Xun
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Epidemiol 171:793-800. 2010
  6. ncbi Toenail selenium as biomarker: reproducibility over a one-year period and factors influencing reproducibility
    Vittorio Krogh
    Unita di Epidemiologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    J Trace Elem Med Biol 17:31-6. 2003
  7. pmc Longitudinal association between toenail selenium levels and measures of subclinical atherosclerosis: the CARDIA trace element study
    Pengcheng Xun
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Atherosclerosis 210:662-7. 2010
  8. pmc Selenium level and cognitive function in rural elderly Chinese
    Sujuan Gao
    Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA
    Am J Epidemiol 165:955-65. 2007
  9. pmc Trace elements in nails as biomarkers in clinical research
    Ka He
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Eur J Clin Invest 41:98-102. 2011
  10. ncbi Comparison of hair, nails and urine for biological monitoring of low level inorganic mercury exposure in dental workers
    J Morton
    Health and Safety Laboratory Sheffield, UK
    Biomarkers 9:47-55. 2004

Research Grants

Detail Information

Publications304 found, 100 shown here

  1. ncbi Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
    A Barel
    Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium
    Arch Dermatol Res 297:147-53. 2005
    ..The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study...
  2. pmc Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire
    Katie M Applebaum
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Environ Health Perspect 115:1231-6. 2007
    ..Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC)...
  3. ncbi Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water
    Angeline S Andrew
    Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 104:263-8. 2003
    ..Although our findings need verification in a larger study group, they are consistent with the hypothesis that inhibition of DNA repair capacity is a potential mechanism for the co-carcinogenic activity of arsenic...
  4. pmc A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Environ Health Perspect 113:1669-74. 2005
    ..both external and endogenous Pb exposure, past or recent exposure, as well as the significance of Pb determinations in human specimens including hair, nails, saliva, bone, blood (plasma, whole blood), urine, feces, and exfoliated teeth.
  5. pmc Associations of toenail selenium levels with inflammatory biomarkers of fibrinogen, high-sensitivity c-reactive protein, and interleukin-6: The CARDIA Trace Element Study
    Pengcheng Xun
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Epidemiol 171:793-800. 2010
    ..Gender, race/ethnicity, smoking status, and selenium supplementation did not appreciably modify these results. This study found no associations between toenail selenium and inflammation as measured by fibrinogen, hs-CRP, and IL-6...
  6. ncbi Toenail selenium as biomarker: reproducibility over a one-year period and factors influencing reproducibility
    Vittorio Krogh
    Unita di Epidemiologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    J Trace Elem Med Biol 17:31-6. 2003
    ..However age, smoking status and acetone treatment are possible causes of misclassification...
  7. pmc Longitudinal association between toenail selenium levels and measures of subclinical atherosclerosis: the CARDIA trace element study
    Pengcheng Xun
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Atherosclerosis 210:662-7. 2010
    ..To examine the longitudinal association between toenail selenium levels and subclinical atherosclerosis over an 18-year period...
  8. pmc Selenium level and cognitive function in rural elderly Chinese
    Sujuan Gao
    Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA
    Am J Epidemiol 165:955-65. 2007
    ..Results in this geographically stable cohort support the hypothesis that a lifelong low selenium level is associated with lower cognitive function...
  9. pmc Trace elements in nails as biomarkers in clinical research
    Ka He
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Eur J Clin Invest 41:98-102. 2011
    ..The importance of trace elements in relation to human health has been increasingly recognized. Accurate and adequate quantification of trace elements are crucial in clinical research...
  10. ncbi Comparison of hair, nails and urine for biological monitoring of low level inorganic mercury exposure in dental workers
    J Morton
    Health and Safety Laboratory Sheffield, UK
    Biomarkers 9:47-55. 2004
    ..finger contact with amalgam or contaminated surfaces rather than systemic incorporation of mercury into growing nails. Good correlation between head hair and pubic hair mercury levels in all subjects was obtained (r=0...
  11. ncbi Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance
    Renate T de Jongh
    Department of Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 109:2529-35. 2004
    ..We hypothesized that obesity is a primary cause of microvascular dysfunction, which may contribute to the development of these obesity-related disorders...
  12. ncbi Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Prostate 52:288-96. 2002
    ..We evaluated the association between prediagnostic toenail cadmium and zinc concentrations and risk of prostate cancer in a cohort in which the primary route of exposure to cadmium and zinc is the diet...
  13. ncbi Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part II. A study of the inhabitants of northern Sweden
    I Rodushkin
    SGAB Analytica, Lulea University of Technology, Sweden
    Sci Total Environ 262:21-36. 2000
    ..Samples (n = 114 for hair and n = 96 for nails) were taken from subjects without known occupational exposure to metals...
  14. ncbi Case-control study of toenail cadmium and prostate cancer risk in Italy
    Marco Vinceti
    Department of Public Health Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Sci Total Environ 373:77-81. 2007
    ..004). Despite the limited statistical stability of the point estimates, these findings appear to support the hypothesis that cadmium exposure increases prostate cancer risk...
  15. ncbi Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part I. Analytical methodology
    I Rodushkin
    SGAB Analytica, Lulea University of Technology, Sweden
    Sci Total Environ 250:83-100. 2000
    ..field inductively coupled plasma mass spectrometry (ICP-SMS) for the determination of 71 elements in hair and nails were studied...
  16. pmc Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study
    P Xun
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, North Carolina, Chapel Hill, NC 27599, USA
    J Intern Med 270:175-86. 2011
    ..The cardioprotective effect of LCω3PUFA intake has been recognized; however, the hypothesis that this benefit may be greatest with high Se and low Hg levels has not been investigated...
  17. ncbi The relationship between amalgam restorations and mercury levels in male dentists and nondental health professionals
    Anil Joshi
    Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Public Health Dent 63:52-60. 2003
    ....
  18. ncbi Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community
    Joel B Wickre
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA
    Arch Environ Health 59:400-9. 2004
    ..Fingernail analysis helped to identify differential exposure pathways in children and adults. Mercury and arsenic uptake via soil exposure in children warrants further consideration...
  19. pmc Yellow nail syndrome: dystrophic nails, peripheral lymphedema and chronic cough
    Christian Dornia
    Department of Radiology, University Medical Center, Regensburg, Germany
    Can Respir J 18:e68-9. 2011
    ..YNS is a rare disorder characterized by yellow, dystrophic nails, peripheral lymphedema and bronchiectasis with recurrent lower respiratory tract infections...
  20. ncbi Acute selenium poisoning by paradise nuts (Lecythis ollaria)
    Dieter Muller
    GIZ Nord Poisons Centre, Universitatsmedizin Gottingen, Georg August Universitat, Gottingen, Germany
    Hum Exp Toxicol 29:431-4. 2010
    ..In retrospect, a relation to the ingestion of paradise nuts could be established...
  21. ncbi Development and evolution of the mammalian limb: adaptive diversification of nails, hooves, and claws
    M W Hamrick
    Department of Anthropology and School of Biomedical Sciences, Kent State University, OH 44242, USA
    Evol Dev 3:355-63. 2001
    ..Likewise, neontological data show that morphological variation in distal limb integumentary appendages (e.g., nails, hooves, and claws) can be observed not only among distantly related mammalian taxa but also among closely related ..
  22. ncbi Testing ethylglucuronide in maternal hair and nails for the assessment of fetal exposure to alcohol: comparison with meconium testing
    Luca Morini
    Department of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy
    Ther Drug Monit 35:402-7. 2013
    ..of ethylglucuronide (EtG) in alternative biological matrices, including neonatal and maternal hair, neonatal meconium, and maternal nails, is receiving increasing interest for the accurate evaluation of the in utero exposure to alcohol.
  23. pmc Associations between toenail arsenic concentration and dietary factors in a New Hampshire population
    Joann F Gruber
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Nutr J 11:45. 2012
    ..However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown...
  24. pmc Fiber diffraction of skin and nails provides an accurate diagnosis of malignancies
    Veronica J James
    Research School of Chemistry, Australian National University, Canberra ACT, Australia
    Int J Cancer 125:133-8. 2009
    ....
  25. ncbi Nail disorders and systemic disease: what the nails tell us
    Stamatis Gregoriou
    University of Athens Medical School, Dermatology Department, Nail Clinic, Athens, Greece
    J Fam Pract 57:509-14. 2008
  26. ncbi Toenail and plasma levels as biomarkers of selenium exposure
    Jessie A Satia
    Department of Nutrition, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Ann Epidemiol 16:53-8. 2006
    ..Little is known about the relationship of these biomarkers with each other or about whether there are differences in the relationships of these biomarkers with diet, supplement use, or participant characteristics...
  27. ncbi [Occurrence of dermatophyte, in nails, feet and hands of university students]
    Emersom Roberto Siqueira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe S N, 14040 903 Ribeirao Preto, SP
    Rev Soc Bras Med Trop 39:269-71. 2006
    The objective of this paper was to evaluate the occurrence of dermatophytes, specifically in the nails, feet and hands of university students with and without lesions. Two hundred and eighty samples were collected; 31 (11...
  28. ncbi Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study
    Jessie Steevens
    GROW School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Gastroenterology 138:1704-13. 2010
    ..Only in very few studies have the associations with ESCC and GCA been investigated, and no epidemiologic studies exist on EAC...
  29. ncbi Background values for essential and toxic elements in children's nails and correlation with hair levels
    Maria Fernanda Hornos Carneiro
    Laboratorio de Toxicologia e Essencialidade de Metais, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe s n, Monte Alegre, 14040 903, Ribeirao Preto, Sao Paulo, Brazil
    Biol Trace Elem Res 144:339-50. 2011
    Human nails are an attractive matrix for assessing environmental exposures to toxic elements as well as the deficiency of essential elements since it is noninvasively collected and can be stored at room temperature...
  30. ncbi Pigmented nails and Strongyloides stercoralis infestation causing clinical worsening in a patient treated for immunoproliferative small intestinal disease: two unusual observations
    U C Ghoshal
    Department of Gastroenterology, Institute of Postgraduate Medical Education and Research, Calcutta, India
    J Diarrhoeal Dis Res 17:43-5. 1999
    ..The patient developed alternate brown black and white lines in the finger nails after combination chemotherapy, which has not been reported earlier in this disease; the nail changes disappeared ..
  31. ncbi No Association between toenail selenium levels and bladder cancer risk
    Dominique S Michaud
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 11:1505-6. 2002
  32. ncbi Reconstruction of finger tip amputations with advancement flap and free nail bed graft
    S Raja Sabapathy
    Department of Plastic, Hand and Reconstructive Microsurgery, Ganja Hospital, Ramnagar, Coimbatore, India
    J Hand Surg Br 27:134-8. 2002
    ..This technique results in an average gain of 5 mm of extra length to the nail. This is a useful technique when replantation of a distal fingertip amputation is not possible...
  33. ncbi Characterization of soluble protein extracts from keratinized tissues: identification of ubiquitin universally distributed in hair, nail, and stratum corneum
    T Inoue
    Basic Research Laboratory, Kanebo Ltd, Odawara, Japan
    Biosci Biotechnol Biochem 65:895-900. 2001
    ..The partial extraction is useful for investigation of soluble proteins retained in the keratinized tissues...
  34. ncbi [Fingertip injuries in children: 81 cases with at least one year follow-up]
    B Salazard
    Service de Chirurgie Plastique, Hôpital Timone Enfants, 264, rue Saint Pierre, 13385 Marseille 05
    Rev Chir Orthop Reparatrice Appar Mot 90:621-7. 2004
    ..Rigorous care is required to avoid esthetic and functional sequelae, but treatment is often difficult. We report our experience focusing on simple therapeutic principles useful for everyday practice in the emergency room...
  35. ncbi Reversible cutaneous hyperpigmentation and nails with white hair due to vitamin B12 deficiency
    Shiro Niiyama
    Department of Dermatology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan
    Eur J Dermatol 17:551-2. 2007
  36. ncbi [Extraction and analysis of nuclear DNA from free margin of nail material]
    Sheng Jie Nie
    School of Forensic Medicine, Kunming Medical College, Kunming 650031, China
    Yi Chuan 29:1373-7. 2007
    ..The traditional organic extraction method works reasonably well for free margin nail DNA isolation, and combination of organic extraction and the Chelex-100 method works best...
  37. ncbi The comparison of nail and serum trace elements in patients with epilepsy and healthy subjects
    Atilla Ilhan
    Department of Neurology, Inonu University Medical School, 44069, Malatya, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 28:99-104. 2004
    ..009). Our results demonstrate that some trace element levels may vary in epileptic patients, and because of the more stable status, the analysis of these element levels in some tissues such as nail might be superior to serum analysis...
  38. ncbi Arsenic and other elements in hair, nails, and skin-scales of arsenic victims in West Bengal, India
    Gautam Samanta
    Department of Civil and Environmental Engineering, University of Houston, N 107 Engineering Bldg 1, Houston, TX 77204 4003, USA
    Sci Total Environ 326:33-47. 2004
    For the first time, biological tissues (hair, nails, and skin-scales) of arsenic victims from an arsenic affected area of West Bengal (WB), India were analyzed for trace elements...
  39. ncbi Efficient DNA extraction from nail clippings using the protease solution from Cucumis melo
    Shumi Yoshida-Yamamoto
    Department of Food Science and Nutrition, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Mol Biotechnol 46:41-8. 2010
    ..In conclusion, we have developed an efficient extraction method for using nail clippings as a genome source and a research tool in molecular epidemiology, medical diagnostics, and forensic science...
  40. ncbi The fingernails of Mary Sullivan: developing reliable methods for selectively isolating endogenous and exogenous DNA from evidence
    Rachel E Cline
    Department of Forensic Sciences, The George Washington University, 2036 H St NW, Washington, DC 20052, USA
    J Forensic Sci 48:328-33. 2003
    ..The nails were extremely friable necessitating the development of new techniques for isolating and purifying DNA...
  41. ncbi Effects of human hair and nail proteins and their films on rat mast cells
    Toshihiro Fujii
    Department of Kansei Engineering, Faculty of Textile Science and Technology, Shinshu University, Tokida 3 15 1, Ueda, 386 8567, Japan
    J Mater Sci Mater Med 19:2335-42. 2008
    ..These results suggest that the human hair and nail proteins and their films will be useful materials for antiallergic actions...
  42. ncbi Identification of N-acetyltransferase 2 and CYP2C19 genotypes for hair, buccal cell swabs, or fingernails compared with blood
    Y Tanigawara
    Department of Hospital Pharmacy, School of Medicine, Kobe University, Kobe, Japan
    Ther Drug Monit 23:341-6. 2001
    ..Both genotypes from these specimens completely matched the genotypes from the blood of the same subject. These nonblood specimens can be convenient, accessible, and economical alternatives to blood as a source of DNA for genotyping...
  43. ncbi Speciation of arsenic in human nail and hair from arsenic-affected area by HPLC-inductively coupled argon plasma mass spectrometry
    Badal Kumar Mandal
    Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Toxicol Appl Pharmacol 189:73-83. 2003
    ..DMA(III) content in fingernails and DMA(V) contents in both fingernails and hair could be the biomarker to As exposure...
  44. ncbi Modified Emmet's operation for ingrown nails using the Er:YAG laser
    U Wollina
    Department of Dermatology, Hospital Dresden Friedrichstadt, Academic Teaching Hospital of the University of Dresden, Dresden, Germany
    J Cosmet Laser Ther 6:38-40. 2004
    Ingrowing nails are a common problem...
  45. ncbi Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasma mass spectrometry (ICP-MS) after tetramethylammonium hydroxide solubilization at room temperature: comparison with ETAAS
    Bruno L Batista
    Laboratorio de Toxicologia e Essencialidade de Metais, Depto de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Avenida do Cafe s n, Monte Alegre 14040 903, Ribeirao Preto SP, Brazil
    Talanta 76:575-9. 2008
    A simple method is described for the determination of Cd, Cu, Mn, Ni, Pb and Zn in nails by using inductively coupled plasma mass spectrometry (ICP-MS) or electrothermal atomic absorption spectrometry (ETAAS)...
  46. pmc Distribution of toenail selenium levels in young adult Caucasians and African Americans in the United States: the CARDIA Trace Element Study
    Pengcheng Xun
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, 2221 McGavran Greenberg, Campus Box 7461, Chapel Hill, NC 27599, USA
    Environ Res 111:514-9. 2011
    ..Data on selenium (Se) levels in American young adults, especially in African Americans, are lacking...
  47. ncbi Long-term follow-up of toenail onychomycosis caused by dermatophytes after successful treatment with systemic antifungal agents
    Bianca Maria Piraccini
    Department of Internal Medicine, Geriatrics and Nephrology, Division of Dermatology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy
    J Am Acad Dermatol 62:411-4. 2010
    ..Recurrences (relapse or reinfection) of onychomycosis are not uncommon, with percentages reported in various studies ranging from 10% to 53%...
  48. ncbi Non-dermatophyte moulds as pathogens of onychomycosis
    Umme Farwa
    Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi
    J Coll Physicians Surg Pak 21:597-600. 2011
    ..To determine the role and pattern of non-dermatophyte moulds as causative agents of onychomycosis...
  49. doi Trichophyton rubrum autoinoculation from infected nails is not such a rare phenomenon
    Jacek C Szepietowski
    Mycoses 51:345-6. 2008
    ..Probably the infection, in the presented case, spread from diseased fingernails. We do postulate that physicians should consider autoinoculation as a not so rare way of fungal infection transmission...
  50. ncbi Nails of newborns in monitoring drug exposure during pregnancy
    Francesco Mari
    Department of Anatomy, Histology, and Legal Medicine, University of Florence, Viale Morgagni 85, I 50134 Firenze, Italy
    Forensic Sci Int 179:176-80. 2008
    This project was developed to investigate the usefulness of newborn nails for monitoring in utero drug exposure...
  51. ncbi The Mozena Classification System and treatment algorithm for ingrown hallux nails
    John D Mozena
    American Board of Podiatric Surgery
    J Am Podiatr Med Assoc 92:131-5. 2002
    ....
  52. pmc Selenium and risk of bladder cancer: a population-based case-control study
    Kristin Wallace
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Prev Res (Phila) 2:70-3. 2009
    ..g., p53 positive) or within certain subsets of a population (e.g., women or moderate smokers)...
  53. ncbi A simple sterile polypropylene fingernail substitute
    P Tos
    UOD Reconstructive Microsurgery, Department of Orthopaedics and Traumatology, ASO CTO Maria Adelaide, Turin, Italy
    Chir Main 28:143-5. 2009
    ..The substitute used in our clinical series protected the nail bed during healing until the growth of the new fingernail and respected our functional expectations...
  54. ncbi Successful treatment of psoriatic nails with low-dose cyclosporine administration
    Tomoko Syuto
    Eur J Dermatol 17:248-9. 2007
  55. ncbi International multicenter psoriasis and psoriatic arthritis reliability trial for the assessment of skin, joints, nails, and dactylitis
    Vinod Chandran
    Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 61:1235-42. 2009
    ..This study aimed to determine whether assessment of the skin and joints in patients with PsA by rheumatologists and dermatologists is reproducible...
  56. ncbi Selenium toxicity: a case of selenosis caused by a nutritional supplement
    Mark E Sutter
    Ann Intern Med 148:970-1. 2008
  57. ncbi Review of antifungal therapy, part II: treatment rationale, including specific patient populations
    Robert Baran
    Nail Disease Centre, Cannes, France
    J Dermatolog Treat 19:168-75. 2008
    ..Combined therapies are shown to increase cure rates. Mechanical interventions are essential in reducing fungal burdens to allow other modalities to penetrate, especially in dermatophytomas and onycholysis...
  58. ncbi Arsenic, cadmium and lead levels in hair and toenail samples in pakistan
    Muhammad Anwar
    Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Environ Sci 12:71-86. 2005
    ....
  59. pmc Evaluation of exposure to arsenic in residential soil
    Joyce S Tsuji
    Exponent, Bellevue, Washington 98007, USA
    Environ Health Perspect 113:1735-40. 2005
    ..Similarly, questionnaire responses indicating soil exposure were not associated with increased urinary arsenic levels. Relatively low soil arsenic exposure likely precluded quantification of arsenic exposure above background...
  60. pmc Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh
    Nurshad Ali
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh
    Environ Health 9:36. 2010
    ..Therefore, in this study, we evaluated the PChE activity in individuals exposed to arsenic via drinking water in Bangladesh...
  61. ncbi Screening for contact allergy to artificial nails
    L Constandt
    Department of Dermatology, University of Ghent, Ghent, Belgium
    Contact Dermatitis 52:73-7. 2005
    27 patients (26 women and 1 man), all in contact with artificial nails, were tested for acrylic compounds, known to be present in nail cosmetics...
  62. ncbi Occupational asthma caused by sculptured nails containing methacrylates
    Riitta Sauni
    Team of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Am J Ind Med 51:968-74. 2008
    In recent decades, the use of artificial nails including methacrylates (MAs) has increased. This study presents the first two clinical cases of occupational asthma (OA) caused by sculptured nails containing MAs.
  63. ncbi Pincer nails: definition and surgical treatment
    R Baran
    Nail Disease Center, 42 rue des Serbes, 06400 Cannes, France
    Dermatol Surg 27:261-6. 2001
    ..There are four main types of ingrown nail. These are distal nail embedding, juvenile (subcutaneous) ingrown nail, hypertrophy of the lateral nail fold (lip), and pincer nail...
  64. ncbi Mercury, fish oils, and the risk of myocardial infarction
    Eliseo Guallar
    Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    N Engl J Med 347:1747-54. 2002
    ..Because fish intake is a major source of exposure to mercury, the mercury content of fish may counteract the beneficial effects of its n-3 fatty acids...
  65. ncbi Mercury and the risk of coronary heart disease in men
    Kazuko Yoshizawa
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 347:1755-60. 2002
    ..A high dietary intake of mercury from consumption of fish has been hypothesized to increase the risk of coronary heart disease...
  66. pmc Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Environ Health Perspect 114:1193-8. 2006
    ....
  67. ncbi The nail as a musculoskeletal appendage--implications for an improved understanding of the link between psoriasis and arthritis
    Dennis McGonagle
    Academic Unit of Musculoskeletal Disease, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Dermatology 218:97-102. 2009
    ..This virtual continuum of connective tissue structures merges with a thick periosteum on the distal phalanx and with the numerous cutaneous ligaments that anchor the fatty pads of the finger pulp to the skin...
  68. ncbi Toenail selenium and cardiovascular disease in men with diabetes
    Swapnil Rajpathak
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Am Coll Nutr 24:250-6. 2005
    ..The aim of this study is to evaluate the association between toenail selenium and CVD among men with diabetes...
  69. ncbi Relative element levels in the paired samples of scalp hair and fingernails of patients from New Delhi
    A Sukumar
    School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Sci Total Environ 372:474-9. 2007
    Specific elements are bioconcentrated in human hair and nails, which have unique advantages of application in population monitoring studies thereby, recognized as biological tools for disease diagnosis and prevention...
  70. doi Precision of high-throughput single-nucleotide polymorphism genotyping with fingernail DNA: comparison with blood DNA
    Mitsuko Nakashima
    Clin Chem 54:1746-8. 2008
  71. ncbi The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all?
    Dennis McGonagle
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Leeds, UK
    Curr Opin Rheumatol 21:340-7. 2009
    ....
  72. ncbi Total arsenic concentrations in toenails quantified by two techniques provide a useful biomarker of chronic arsenic exposure in drinking water
    Blakely M Adair
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, North Carolina 27711, USA
    Environ Res 101:213-20. 2006
    ..These results suggest that toenails are a better biomarker of chronic As exposure than urine in the current study, because the sequestration of As in toenails provides an integration of exposure over time that does not occur in urine...
  73. ncbi Toenail mercury and dietary fish consumption
    Judy R Rees
    Dartmouth College Center for Environmental Health Sciences, Department of Community and Family Medicine Biostatistics and Epidemiology and Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    J Expo Sci Environ Epidemiol 17:25-30. 2007
    ..48, P=0.012). Multivariate models confirmed that toenail total mercury concentration was best predicted by total finfish and shellfish consumption...
  74. ncbi Influence of growth rate and length on fluoride detection in human nails
    M A R Buzalaf
    Department of Biological Sciences, Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Caries Res 40:231-8. 2006
    This study aimed to determine the lag time between increased fluoride (F) intake and F detection in human nails, as well as the influence of nails growth rate and length on this. Ten 20- to 35-year-old volunteers received 1...
  75. ncbi Toenails as a biomarker of inorganic arsenic intake from drinking water and foods
    Melissa J Slotnick
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    J Toxicol Environ Health A 70:148-58. 2007
    ....
  76. ncbi Stable (2)H isotope analysis of modern-day human hair and nails can aid forensic human identification
    Isla Fraser
    Environmental Forensics and Human Health Lab, Environmental Engineering Research Centre, Queen s University Belfast, Belfast BT9 5AG, UK
    Rapid Commun Mass Spectrom 21:3279-85. 2007
    ..86), while the corresponding correlation for nails was not as strong (r(2) = 0.6)...
  77. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
    ..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality...
  78. ncbi Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among residents in Mansoura city, Nile delta, Egypt
    Wael I Mortada
    Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
    Environ Res 90:104-10. 2002
    ..in Mansoura city, Egypt, was examined for concentrations of cadmium, lead, and mercury in blood, urine, hair, and nails. The effect of gender and smoking on such levels was studied...
  79. ncbi Isolated finger injuries in children--incidence and aetiology
    N V Doraiswamy
    Department of Accident and Emergency Medicine, Royal Hospital for Sick Children, Glasgow, Scotland, G3 8SJ, UK
    Injury 31:571-3. 2000
    ..Both children and adults should be educated about causation, reiterating that damage to fingers can be prevented or reduced by observing safety measures...
  80. ncbi Human toenails as a biomarker of exposure to elevated environmental arsenic
    Mark Button
    British Geological Survey, Keyworth, Nottingham, NG12 5GG, UK
    J Environ Monit 11:610-7. 2009
    ..Toenails are presented as a viable biomarker of exposure at sites with elevated environmental As, such as the former mining sites found throughout Devon and Cornwall, UK...
  81. ncbi Management of difficult to treat locations of psoriasis. Scalp, face, flexures, palm/soles and nails
    Knud Kragballe
    Department of Dermatology, Arhus University Hospital, Arhus, Denmark
    Curr Probl Dermatol 38:160-71. 2009
    Psoriasis located on the scalp, face, skin folds, palms/soles and nails may require special consideration due to physical disability and discomfort, and because the treatment efficacy and safety may be different...
  82. ncbi Nail antioxidant trace elements are inversely associated with inflammatory markers in healthy young adults
    Blanca Puchau
    Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Calle Irunlarrea 1, 31008, Pamplona, Spain
    Biol Trace Elem Res 133:304-12. 2010
    ....
  83. pmc Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men
    Anna L Choi
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:367-72. 2009
    ..Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality...
  84. ncbi Interaction between chronic arsenic exposure via drinking water and plasma lactate dehydrogenase activity
    Md Rezaul Karim
    Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, Bangladesh
    Sci Total Environ 409:278-83. 2010
    ..Arsenic content in drinking water, hair and nails were estimated by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) and LDH activity was assayed by a ..
  85. ncbi The role of stable isotopes in human identification: a longitudinal study into the variability of isotopic signals in human hair and nails
    I Fraser
    Environmental Forensics and Human Health, Environmental Engineering Research Centre, Queen s University Belfast, Belfast BT9 5AG, UK
    Rapid Commun Mass Spectrom 20:1109-16. 2006
    ..A hypothesis explaining this trend is put forward based on the faster rate of formation of hair than of nails. This means that there is less time for the compounds forming hair to be affected by biochemical processes that ..
  86. ncbi Morphologic study of normal, ingrown, and pincer nails
    Masaaki Kosaka
    Department of Plastic and Reconstructive Surgery, Kinki University School of Medicine, Osakasayama City, Osaka, Japan
    Dermatol Surg 36:31-8. 2010
    ..Pincer nail has been confused with ingrown nail for decades...
  87. ncbi Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road Section1, Taipei 10018, Taiwan, ROC
    Toxicol Appl Pharmacol 206:198-206. 2005
    ..Gene-gene and gene-environment interactions are involved in arsenic-induced health hazards through toxicological mechanisms including genomic instability and oxidative stress...
  88. ncbi Collection of fungi samples from nails: comparative study of curettage and drilling techniques
    A Shemer
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    J Eur Acad Dermatol Venereol 22:182-5. 2008
    ..Obtaining a positive laboratory test before treatment is important in clinical practice because the treatment of onychomycosis requires expensive oral antifungal therapy with potentially serious side-effects...
  89. ncbi Profiles of trace elements in toenails of Arab-Americans in the Detroit area, Michigan
    Melissa J Slotnick
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Biol Trace Elem Res 107:113-26. 2005
    ..These investigations provide insight into exposures and factors influencing exposures in this population while adding to the growing fund of knowledge surrounding use of toenails as a marker of exposure...
  90. ncbi Laser Doppler perfusion imaging is useful in the study of Raynaud's phenomenon and improves the capillaroscopic diagnosis
    Edoardo Rosato
    Department of Clinical Medicine, Clinical Immunology Unit Scleroderma Center, Sapienza University of Rome, Rome, Italy
    J Rheumatol 36:2257-63. 2009
    ....
  91. ncbi Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    Am J Epidemiol 152:84-90. 2000
    ..08 (p = 0.31) among those with concentrations below 1 microg/liter (overall r = 0.46, p < 0.001). Our data suggest that toenail samples provide a useful biologic marker for quantifying low-level arsenic exposure...
  92. ncbi Use of human nails as bio-indicators of heavy metals environmental exposure among school age children in Kenya
    Faridah Hussein Were
    Department of Chemistry in the School of Pure and Applied Sciences at Kenyatta University, Nairobi, Kenya
    Sci Total Environ 393:376-84. 2008
    ..241). The association of toxic metals in the nails of children with environmental exposure, and nutritional status implies that policies and actions to reduce heavy ..
  93. ncbi Arsenic in hair and nails of individuals exposed to arsenic-rich groundwaters in Kandal province, Cambodia
    Andrew G Gault
    University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom
    Sci Total Environ 393:168-76. 2008
    ....
  94. ncbi Prediagnostic toenail selenium and risk of bladder cancer
    Maurice P A Zeegers
    Department of Epidemiology, Maastricht University, The Netherlands
    Cancer Epidemiol Biomarkers Prev 11:1292-7. 2002
    ..We conclude that the evidence is in favor of an inverse association between selenium and bladder cancer risk...
  95. ncbi Noninvasive imaging techniques in the assessment of scleroderma spectrum disorders
    Andrea K Murray
    School of Translational Medicine, University of Manchester, Salford Royal NHS Foundation Trust, Salford, UK
    Arthritis Rheum 61:1103-11. 2009
    ....
  96. pmc Chronic arsenic exposure and oxidative stress: OGG1 expression and arsenic exposure, nail selenium, and skin hyperkeratosis in Inner Mongolia
    Jinyao Mo
    National Research Council, Washington, DC, USA
    Environ Health Perspect 114:835-41. 2006
    ..OGG1 expression levels were linked to As concentrations in drinking water and nails, selenium concentrations in nails, and skin hyperkeratosis...
  97. ncbi Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study
    M R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Epidemiol 153:559-65. 2001
    ....
  98. ncbi Human nails as a biomarker of arsenic exposure from well water in Inner Mongolia: comparing atomic fluorescence spectrometry and neutron activation analysis
    M T Schmitt
    US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biomarkers 10:95-104. 2005
    ..instrumental neutron activation analysis (INAA) and atomic fluorescence spectrometry (AFS), and to verify nails as an exposure biomarker in this population. In 1999, nail and water samples were collected in a pilot study...
  99. ncbi Validity of human nails as a biomarker of arsenic and selenium exposure: A review
    Melissa J Slotnick
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA
    Environ Res 102:125-39. 2006
    ..In this review, the use of human nails to measure exposure to arsenic and selenium is discussed in the context of the biomarker validation framework...
  100. ncbi Ultrasound imaging of nails
    Ximena Wortsman
    Imaging Department, Hospital del Professor, Alameda 4860, Santiago, Chile
    Dermatol Clin 24:323-8. 2006
    ..Characteristic ultrasound pictures can be seen in psoriasis, cysts, vascular abnormalities,and other nail diseases. Ultrasound examination can visualize and quantify morphologic and functional aspects of nail biology...
  101. ncbi Outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails
    Archana Gupta
    Department of Pediatrics, Columbia University, New York Presbyterian Hospital, New York, New York 10032, USA
    Infect Control Hosp Epidemiol 25:210-5. 2004
    ..From April to June 2001, an outbreak of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae infections was investigated in our neonatal intensive care unit...

Research Grants62

  1. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..by their limited lifespan in vitro, and by anatomic deficiencies, including absence of hair, glands and nails. The investigators have demonstrated stable wound closure in burns, chronic wounds and giant nevi with autologous ..
  2. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..been followed to age 2 years, involving the collection of extensive Pb, Mn, and As biomarker data (blood, hair, nails), providing a record of lifetime (including prenatal) exposures to these metals...
  3. Studying a Human Stem Cell Disease Using iPS Technology
    Steven E Artandi; Fiscal Year: 2010
    ..Aplastic anemia in patients with DC is accompanied by defects in other tissues, including oral mucosa, nails and lung, among other tissues...
  4. The role of IFT80 in bone formation
    Shuying Yang; Fiscal Year: 2013
    ..in mice results in a variety of skeletal and craniofacial abnormalities as well as alterations in the teeth and nails. Mice with targeted deletion of IFT/cilia have a wide variety of bone phenotypes that provide interesting insights ..
  5. Center for Biophysical Assessment and Risk Management Following Irradiation
    Paul Okunieff; Fiscal Year: 2009
    ..a technology that uses the spin traps in the carbonate of tooth enamel (or bone) and in sulfate of hair and nails, much in the same way as film dosimetry uses silver nitrate...
  6. International Conference for Ectodermal Dysplasias Classification
    Carlos F Salinas; Fiscal Year: 2012
    ..He based his classification on the observed clinical phenotype affecting mainly the hair, teeth, sweat pores and nails. According to this classification there are over 170 conditions that could be considered an ectodermal dysplasias...
  7. Mouse nude locus and skin development
    Janice L Brissette; Fiscal Year: 2013
    ..the nude phenotype, which is characterized by the abnormal morphogenesis of the skin, thymus, mammary gland, and nails. Based on our work to date, we have developed the following model of Foxn1 function...
  8. Cancer Epidemiology Cohort in Male Health Professionals
    Walter C Willett; Fiscal Year: 2013
    ..The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers...
  9. Nutrition and the Genetics of Prematurity
    Hyagriv N Simhan; Fiscal Year: 2010
    ..Nutritional status is represented by dietary intake, nutritional biomarkers in maternal blood and nails, pre-pregnancy body mass index, and weight gain...
  10. Neurologic function in children exposed to ambient manganese
    Donald R Smith; Fiscal Year: 2013
    ..cognitive, behavioral, motor, and sensory assessments, along with exposure biomarker measures (blood, urine, hair, nails) and Mn in shed deciduous teeth to assess early life and cumulative lifetime exposures...
  11. Molecular, immunological, and clinical dissection of STAT1 hypermorphic mutations
    Steven M Holland; Fiscal Year: 2013
    ..by applicant): Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent disease of the nails, skin, oral and genital mucosae...
  12. Role of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and Function
    Johann Eli Gudjonsson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriasis is a common chronic debilitating disease of the skin, nails and joints with a major impact on the quality of life to levels comparable to those seen in cancer, diabetes and heart disease...
  13. Physically-Based Biodosimetry for Triage After a Large Radiation Incident
    Harold M Swartz; Fiscal Year: 2013
    ..focused on the development of field deployable physical biodosimetry utilizing EPR measurements of teeth and nails through three synergistic projects and highly integrated cores based on prior progress...
  14. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    ..that commonly grows in the respiratory tract, and dermatophytes of the genus Trichophyton that grow on the skin or nails. The important allergens will be purified, characterized, and cloned to derive the amino acid or nucleotide ..
  15. The glyoxylate cycle as a new target for antifungals
    Claude Selitrennikoff; Fiscal Year: 2003
    ..of the skin and mucous membranes such as athlete's foot, vaginal yeast infections, and infections of keratinized nails. However, an ominously increasing number of fungi cause systemic disease with the involvement of internal organs...
  16. Antifungal drugs: Beta(1,6)-glucan synthesis inhibitors
    Claude Selitrennikoff; Fiscal Year: 2003
    ..of the skin and mucous membranes such as athlete's foot, vaginal yeast infections, and infections of keratinized nails. However, an ominously increasing number of fungi cause systemic disease with the involvement of internal organs...
  17. A molecular toolbox for hypothesis testing in the dermatophytes
    Theodore C White; Fiscal Year: 2010
    ..These molds cause infections within the skin and nails, including athlete's foot, the most common fungal infection worldwide...
  18. Selenium against arsenic toxicity and skin lesions
    JULIAN SPALLHOLZ; Fiscal Year: 2005
    ..Tertiary/Exploratory: Se content of hair and nails, measured alongside As by HG-AFS and NAA...
  19. REGULATION OF EPIDERMAL DIFFERENTATION BY PTHRP
    John Foley; Fiscal Year: 2004
    ..The dermis also signals the epidermis to produce hair, sweat glands, and nails in their proper places...
  20. Electropulsation mediated drug therapy for Onychomycosis
    SATHYANARAYANA MURTHY; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Currently the fungal infection of nails (onychomycosis) is treated with oral and topical antifungal drugs...
  21. MOLECULAR AND GENETIC ANALYSIS OF THE EEC SYNDROME
    Bernard Weissman; Fiscal Year: 2000
    ..consist of diseases with developmental abnormalities of ectodermal tissue primarily the hair, skin, teeth, and nails. Many forms of this disease present with other types of developmental disorders suggesting a common genomic ..
  22. SPRINT- Randomized Trial of Tibial Fracture Fixation
    Marc Swiontkowski; Fiscal Year: 2006
    ..Surgeons agree that intramedullary nails are the implant of choice when surgery is indicated...
  23. BLOOD AND DATA BANK FOR CANCER RISK FACTOR STUDIES
    George Comstock; Fiscal Year: 1992
    ..Dietary histories and information from plasma, white blood cells, and toe nails will be analyzed for limited nested case-control studies of specific cancers as these develop among participants ..
  24. MOLECULAR GENETICS OF NAIL PATELLA SYNDROME
    Iain McIntosh; Fiscal Year: 2004
    ..The syndrome is characterized by dysplasia of the nails, patellae and elbows, as well as open angle glaucoma and potentially lethal nephropathy...
  25. Actuator for Bone Lengthening/Transport System:Phase II
    Thomas Walter; Fiscal Year: 2003
    ..and remotely controlled - will be developed, tested and combined with a largely existing suite of intramedullary nails and associated implant hardware...
  26. Development of a New Topical Antifungal Agent
    Sheldon Pinnell; Fiscal Year: 2002
    ..It may be useful as a topical treatment for fungal infections of skin and nails. We will test its effectiveness against a battery of fungi, explore the antifungal capabilities of similar ..
  27. INTERLOCKING NAIL PLACEMENT WITHOUT FLUOROSCOPY
    GREGORY MERCURI; Fiscal Year: 2000
    ..plans to manufacture and market an IM targeting device and guide system for screw placement in interlocking nails. The system will work with cannulated, interlocking nails currently on the market or with an interlocking nail of ..
  28. Conference--Dermatologic Disease in Skin of Color
    Susan Taylor; Fiscal Year: 2002
    ..Each topic will include several presentations pertaining to African American, Latino, and Asian skin, hair and nails and will conclude with a discussion panel...
  29. TARGETING DEVICE FOR INTRAMEDULLARY NAIL LOCKING SCREWS
    RUBEN ZAMORANO; Fiscal Year: 1999
    ..related to the targeting and drilling of holes in bone corresponding to the distal screw holes in intramedullary nails (IM), thereby reducing the duration and cost of current IM nailing methods...
  30. GORDON CONFERENCE--EPITHELIAL DIFFERENTIATION AND KERATI
    Elaine Fuchs; Fiscal Year: 1999
    ..Transcriptional regulators in epithelia 2. Lessons from Drosophila 3. Internal epithelia 4. The cornified envelope 5. Hair, nails and teeth 6. Control of epithelial growth and differentiation
  31. Magnetic Targeting for Insertion of Distal Screws into Intramedullary Nails
    Patrick Lichter; Fiscal Year: 2008
    ..design and prototype a magnetic targeting system used to insert screws into the distal holes of intramedullary nails. The proposed system will allow an orthopedic surgeon to easily and quickly locate the distal holes, align the ..
  32. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..The information obtained in this study will be relevant to millions of children in the US and abroad who are chronically exposed to lead, cadmium, and arsenic in the environment. ..
  33. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  34. Effectiveness of patient lift equipment
    Hester Lipscomb; Fiscal Year: 2008
    ..The proposed work addresses several NIOSH priority areas including health care workers, back injuries, and intervention effectiveness research. ..
  35. Mercury, Arsenic, and Carotid Atherosclerosis
    Eliseo Guallar; Fiscal Year: 2007
    ..Relevance: Confirmation of the role of mercury or arsenic on atherogenesis could impact current environmental and dietary public health recommendations. [unreadable] [unreadable]..
  36. A prospective study of diet and adult gliomas
    Dominique Michaud; Fiscal Year: 2005
    ..This study should contribute substantially to our understanding of the relation between diet and the risk of adult gliomas, and might provide opportunities for prevention of this deadly disease. ..
  37. Heavy Metals, Obesity and Cardiovascular Risk
    Eliseo Guallar; Fiscal Year: 2005
    ....
  38. WORK AND HEALTH DISPARITIES AMONG RURAL WOMEN
    Hester Lipscomb; Fiscal Year: 2004
    ..Education will also be targeted to medical providers in this geographic area on work exposures and conditions, exposure response, prevention, basic epidemiology, and ergonomics. ..
  39. Back Disorders in Union Carpenters
    Hester Lipscomb; Fiscal Year: 2006
    ..The project addresses a number of areas of expressed interest to NIOSH including construction workers, back disorders, surveillance methods and health services research. [unreadable] [unreadable]..
  40. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
  41. STATISTICAL METHODS IN LONGITUDINAL STUDIES OF DEMENTIA
    Sujuan Gao; Fiscal Year: 2003
    ..The applicant states that the methods developed in this proposal are widely applicable to other epidemiological studies using longitudinal two-phase sampling designs. ..
  42. PRENATAL STRESS AND IMMUNE RESPONSIVENESS
    Christopher Coe; Fiscal Year: 2004
    ....
  43. HOXA13 AMINO-TERMINAL FUNCTIONAL DOMAINS
    JEFFREY INNIS; Fiscal Year: 2004
    ..We will inject these modified ES cells into blastocysts to create chimeric mice, obtain germline transmission of the mutant alleles, and characterize the limb phenotypes associated with these mutations. ..
  44. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2004
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..
  45. INFRASTRUCTURE FOR RESEARCH ON MENTAL DISABILITIES
    Roger Stevenson; Fiscal Year: 2003
    ....
  46. Obstacles to Answering Physicians' Patient-Care Question
    John Ely; Fiscal Year: 2003
    ..Benefit: By identifying areas where knowledge resources fail to meet the needs of physicians, we will provide recommendations to help knowledge base developers better meet those needs. ..
  47. Organ Culture of Basal Cell Carcinoma
    James Elder; Fiscal Year: 2002
    ....
  48. MOUSE MODELS OF DNA REPAIR - DEFECTIVE HUMAN DISEASES
    Errol Friedberg; Fiscal Year: 2011
    ..abstract_text> ..
  49. Plant Foods and Endometrial Cancer Epidemiology
    PAMELA HORN ROSS; Fiscal Year: 2005
    ..A priori definitions and factor analysis will be used to identify dietary patterns. The results of the proposed analyses will provide further understanding of the etiology of endometrial cancer. ..
  50. Nutrition and Thyroid Cancer Risk in the CTS Cohort
    PAMELA HORN ROSS; Fiscal Year: 2007
    ..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. [unreadable] [unreadable] [unreadable]..
  51. Trace Elements and Cardiovascular Disease (CVD) Risks Factors Among Young Adults
    Ka He; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  53. Studies of Nailfold Plexus Visibility in Schizophrenia
    JOHN VUCHETICH; Fiscal Year: 2008
    ..Furthermore, progress in understanding the genetic causes of schizophrenia should ultimately improve prevention, diagnosis and treatment of this common and devastating disorder. [unreadable] [unreadable] [unreadable]..
  54. Expandable Shape-Memory Polymers for Suture Anchors
    CHRISTOPHER YAKACKI; Fiscal Year: 2008
    ..This project will provide a means to restore function to their shoulders with less occurrence of surgical failure and increase their quality of life. [unreadable] [unreadable] [unreadable]..
  55. Genetic Mechanisms of Vertebrate Caudal Limb Field Specification
    JEFFREY INNIS; Fiscal Year: 2007
    ..Public Health: This work will have broad significance to our understanding of embryonic development as well as the basis for very common human birth defects involving caudal structures and limbs. [unreadable] [unreadable] [unreadable]..
  56. Annual Mentoring Program in PsychoNeuroImmunology (PNI) Research
    Christopher Coe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  58. Phase Ib trial of TD101 siRNA for pachyonychia congenita (IND 77,504, 12-03-07)
    Sancy Leachman; Fiscal Year: 2009
    ....
  59. Genetic analysis of congenital diaphragmatic hernia
    Anne Slavotinek; Fiscal Year: 2006
    ..abstract_text> ..
  60. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
  61. DNA REPAIR AND CANCER PRONE HEREDITARY HUMAN DISEASE
    Errol Friedberg; Fiscal Year: 2002
    ....