lymphatic vessels

Summary

Summary: Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.

Top Publications

  1. doi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
  2. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
  3. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
  4. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
  5. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
  6. doi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
  7. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
  8. doi The lymphatic vasculature in disease
    Kari Alitalo
    Molecular Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Nat Med 17:1371-80. 2011
  9. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
  10. ncbi Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004

Detail Information

Publications249 found, 100 shown here

  1. doi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
    The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a ..
  2. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes...
  3. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    b>Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema...
  4. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    ..known that both macrophages and blood vessels are critical to wound repair, the role of wound-associated lymphatic vessels has not been well investigated...
  5. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    Lymphangiogenesis is associated with human and murine cancer metastasis, suggesting that lymphatic vessels are important for tumor dissemination...
  6. doi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
    ..Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth...
  7. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
    ..Whereas little or no HGF-R expression was detected by lymphatic vessels of normal tissues, HGF-R was strongly expressed by regenerating lymphatic endothelium during tissue repair ..
  8. doi The lymphatic vasculature in disease
    Kari Alitalo
    Molecular Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Nat Med 17:1371-80. 2011
    Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way conduit for tissue fluid and leukocytes...
  9. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
    ....
  10. ncbi Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004
    ....
  11. doi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  12. pmc Lymphatic vascular morphogenesis in development, physiology, and disease
    Stefan Schulte-Merker
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
    J Cell Biol 193:607-18. 2011
    ..Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation...
  13. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
    ....
  14. pmc Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    Eleni Bazigou
    Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 17:175-86. 2009
    ..Our findings reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects...
  15. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..the origins of the lymphatic system in the embryo, and the mechanisms that direct growth of the network of lymphatic vessels, remain unclear...
  16. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
    ..We conclude that the mammalian lymphatic system has a solely venous origin...
  17. pmc Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways
    Li Chin Yao
    Department of Anatomy, University of California, 513 Parnassus Ave, Room S1363, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:1525-41. 2010
    ..We suggest that lymphatic remodeling that persists after the initial inflammatory response has resolved may influence subsequent inflammatory episodes in clinical situations...
  18. pmc Current views on the function of the lymphatic vasculature in health and disease
    Yingdi Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 24:2115-26. 2010
    ..In this review, we summarize the functional roles of the lymphatic vasculature in health and disease...
  19. pmc Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
    Holger Pflicke
    Max Planck Institute of Biochemistry, Hofschneider Group Leukocyte Migration, 82152 Martinsried, Germany
    J Exp Med 206:2925-35. 2009
    ..rates, leukocyte extravasation from the blood circulation is well investigated, whereas intravasation into lymphatic vessels has hardly been studied...
  20. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
    Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates...
  21. doi Molecular control of lymphatic metastasis
    Marc G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Ann N Y Acad Sci 1131:225-34. 2008
    ..Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis...
  22. doi Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution
    Raghu P Kataru
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Guseong Dong, Daejeon, Korea
    Blood 113:5650-9. 2009
    Using a bacterial pathogen-induced acute inflammation model in the skin, we defined the roles of local lymphatic vessels and draining lymph nodes (DLNs) in antigen clearance and inflammation resolution...
  23. pmc FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
    Camilla Norrmen
    Molecular Cancer Biology Program, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Cell Biol 185:439-57. 2009
    ..of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process...
  24. pmc Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
    Gudrun F Debes
    Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:889-94. 2005
    ..The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation...
  25. ncbi Lymphatic vessels in cancer metastasis: bridging the gaps
    Ramin Shayan
    Angiogenesis Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Carcinogenesis 27:1729-38. 2006
    ..aims to summarize these contributions, in terms of the history, identification, structure and function of lymphatic vessels in cancer and the role they play in tumour metastasis...
  26. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
    ..Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction...
  27. pmc Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels
    Philipp Steven
    Department of Ophthalmology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e26253. 2011
    The role of lymphatic vessels in tissue and organ transplantation as well as in tumor growth and metastasis has drawn great attention in recent years.
  28. pmc Netrin-4 activates endothelial integrin {alpha}6{beta}1
    Frederic Larrieu-Lahargue
    University of Utah, Eccles Institute of Human Genetics, Salt Lake City, UT 84112, USA
    Circ Res 109:770-4. 2011
    ..Netrin family members were shown to signal through a range of receptors, including integrins (such as α3β1, α6β1, and α6β4) in nonendothelial cells...
  29. doi CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
    Frank L Bos
    Hubrecht Institute KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Circ Res 109:486-91. 2011
    ..Insight into the molecular role of CCBE1 is completely lacking, and mouse models for the disease do not exist...
  30. doi Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients
    Annika Algars
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J Cancer 131:864-73. 2012
    ..Here, we elucidated the prognostic significance of lymphatic vessels, different types of macrophages and the balance between different macrophage types in colorectal cancer...
  31. pmc Lymphovascular invasion in colorectal cancer: an interobserver variability study
    Elizabeth I Harris
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Surg Pathol 32:1816-21. 2008
    ..This study was undertaken to examine such interobserver variability, and we hypothesized that the use of immunohistochemical markers for vascular and lymphatic channels could improve interobserver agreement...
  32. doi Role of lymphatic vessels in tumor immunity: passive conduits or active participants?
    Amanda W Lund
    Institute of Bioengineering and Swiss Institute of Experimental Cancer Research, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Mammary Gland Biol Neoplasia 15:341-52. 2010
    ..This review presents emerging evidence that lymphatic vessels are active modulators of immunity, perhaps fine-tuning the response to adjust the balance between peripheral ..
  33. ncbi Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation
    Margaret Thompson
    Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Ann Surg Oncol 14:1890-5. 2007
    ..Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema...
  34. ncbi Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 19:392-8. 2006
    ..b>Lymphatic vessels were detected by immunohistochemical stain using an antibody specific for the lymphatic endothelial cells (..
  35. doi MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vessels
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
    Microvasc Res 76:42-5. 2008
    To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels.
  36. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012
    ..Third, lymphatic vessels emerge by a combination of mechanisms including sprouting from the lymph sacs and direct delamination of ..
  37. pmc Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature
    Jan Kazenwadel
    Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, 5000 SA, Australia
    Blood 119:1283-91. 2012
    ..Primary lymphedema occurs as a result of aberrations in the development and/or function of lymphatic vessels, spurring us to investigate whether GATA2 plays a role in the lymphatic vasculature...
  38. doi Fibrosis is a key inhibitor of lymphatic regeneration
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 124:438-50. 2009
    ..The purpose of these experiments was therefore to evaluate lymphatic regeneration in the setting of variable soft-tissue fibrosis...
  39. pmc Induction of lymphatic endothelial cell differentiation in embryoid bodies
    Ruediger Liersch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Blood 107:1214-6. 2006
    ..Our results reveal, for the first time, that ES cells can differentiate into lymphatic endothelial cells, and they identify the EB assay as a powerful new tool to dissect the molecular mechanisms that control lymphatic vessel formation...
  40. pmc Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  41. pmc Combined blockade of VEGFR-2 and VEGFR-3 inhibits inflammatory lymphangiogenesis in early and middle stages
    Don Yuen
    Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 52:2593-7. 2011
    ..The purpose of this study was to investigate whether there is a time window for therapeutic intervention of corneal LG and whether a combined blockade of VEGFR-2 and VEGFR-3 effectively suppresses early-, middle-, or late-stage LG...
  42. ncbi Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome
    Susan L Dagenais
    Department of Human Genetics, University of Michigan, 4909 Buhl, Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Gene Expr Patterns 4:611-9. 2004
    ....
  43. pmc Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development
    Fei Zhou
    Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China
    Am J Pathol 177:2124-33. 2010
    ..There was an uncharacteristic enlargement of collecting lymphatic vessels, and further analysis showed that smooth muscle cell coverage of collecting lymphatic vessels became much ..
  44. doi Tumor metastasis and the lymphatic vasculature
    Jonathan P Sleeman
    Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany
    Int J Cancer 125:2747-56. 2009
    Tumor-associated lymphatic vessels act as a conduit by which disseminating tumor cells access regional lymph nodes and form metastases there...
  45. pmc Netrin-4 induces lymphangiogenesis in vivo
    Frederic Larrieu-Lahargue
    Program in Molecular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Blood 115:5418-26. 2010
    ..Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation...
  46. ncbi Synchrony of high endothelial venules and lymphatic vessels revealed by immunization
    Shan Liao
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:3369-79. 2006
    ....
  47. doi Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
    Benjamin M Hogan
    Hubrecht Institute KNAW and University Medical Centre, Utrecht, The Netherlands
    Nat Genet 41:396-8. 2009
    b>Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of ..
  48. doi Hyaluronic acid-quantum dot conjugates for in vivo lymphatic vessel imaging
    Suk Ho Bhang
    Department of Bioengineering, Hanyang University, Seoul 133 791, Korea
    ACS Nano 3:1389-98. 2009
    ..The conjugates are also demonstrated for the fluorescence staining capability for lymphatic vessels in vitro and in vivo...
  49. doi Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 184:535-9. 2010
    The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation...
  50. pmc An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, and Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham Medical School, UK
    J Exp Med 203:2763-77. 2006
    ..How such an exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels are unknown...
  51. ncbi Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia
    Rainer Kunstfeld
    Cutaneous Biology Research Center, Massachusetts General Hospital, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Blood 104:1048-57. 2004
    ..They also indicate that inhibition of VEGF-A bioactivity might be a new approach to anti-inflammatory therapy...
  52. pmc The lymphatic system in health and disease
    Leah N Cueni
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Lymphat Res Biol 6:109-22. 2008
    ..The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of in vitro and in vivo models to study various ..
  53. pmc Targeting lymphangiogenesis to prevent tumour metastasis
    M G Achen
    Ludwig Institute for Cancer Research, Post Office Box 2008 Royal Melbourne Hospital, Victoria 3050, Australia
    Br J Cancer 94:1355-60. 2006
    ..animal models of cancer and clinicopathological analyses of human tumours suggest that the growth of lymphatic vessels (lymphangiogenesis) in or nearby tumours is associated with the metastatic spread of cancer...
  54. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009
    ..We conclude that TNF-alpha is a strong candidate for a mediator that drives blood vessel remodeling and lymphangiogenesis in inflammation...
  55. doi Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
    ..The heterogeneity of expression of markers in both blood and lymphatic vessels reflects underlying differences in the phenotype of endothelial cells...
  56. ncbi Alcian blue staining method to visualize bonghan threads inside large caliber lymphatic vessels and x-ray microtomography to reveal their microchannels
    Changhoon Lee
    Biomedical Physics Laboratory, FPRD, School of Physics and Astronomy, Seoul National University, Seoul, Korea
    Lymphat Res Biol 4:181-90. 2006
    Novel threadlike structures, so-called Bonghan threads, inside large caliber lymphatic vessels were recently observed by using the Janus Green B staining in the case of rabbits, and by using fluorescent magnetic nanoparticles for rats...
  57. pmc Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Am J Pathol 171:361-72. 2007
    ..In contrast, the role of integrins in lymphangiogenesis, ie, the outgrowth of new from pre-existing lymphatic vessels, has so far been unclear...
  58. pmc Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity
    Evisa Gjini
    Hubrecht Institute KNAW and University Medical Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Dis Model Mech 4:57-66. 2011
    ..Our study introduces an additional vertebrate model to study in vivo the function of Tie-2 in development and disease...
  59. doi Intratumoral lymphatic vessel involvement is an invasive indicator of completely resected pathologic stage I non-small cell lung cancer
    Masahiko Harada
    Division of Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
    J Thorac Oncol 6:48-54. 2011
    ..Comprehensive patient selection for adjuvant chemotherapy should be based on proven risk factors...
  60. pmc Apelin attenuates UVB-induced edema and inflammation by promoting vessel function
    Mika Sawane
    Shiseido Innovative Science Research Center, Yokohama, Japan
    Am J Pathol 179:2691-7. 2011
    ..endothelial cells mediates APJ regulation of blood vessel caliber size; however, the function of apelin in lymphatic vessels is unclear...
  61. doi Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography
    Ning Fei Liu
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Vasc Surg 49:980-7. 2009
    ..This study evaluated the anatomic and functional images of contrast MR lymphangiography in the diagnosis of limb lymphatic circulation disorders...
  62. pmc Nitric oxide formation by lymphatic bulb and valves is a major regulatory component of lymphatic pumping
    H Glenn Bohlen
    Department of Cellular and Integrative Physiology, Indiana University Medical School, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 301:H1897-906. 2011
    ..In effect, NO generation by the bulb area and its valves limits the pumped flow of the total lymphatic by lowering frequency and stroke volume of individual contractions...
  63. doi Lymphoedematous variants of Kaposi's sarcoma
    L Pantanowitz
    J Eur Acad Dermatol Venereol 22:118-20. 2008
  64. ncbi Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, the Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Circ Res 100:1468-75. 2007
    ..However, both chimeras induced a distinctly different pattern of lymphatic vessels when compared with VEGF-C...
  65. pmc Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Physiol Cell Physiol 299:C589-605. 2010
    ..Radiation therapy decreases lymphatic reserve by causing depletion of lymphatic vessels and LECs as well as promoting soft tissue fibrosis...
  66. doi Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
    Annelii Ny
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    Blood 112:1740-9. 2008
    ..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
  67. doi Axillary reverse mapping: mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy
    Cristiano Boneti
    Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Winthrop P Rockefeller Cancer Institute, Little Rock, AR, USA
    J Am Coll Surg 206:1038-42; discussion 1042-4. 2008
    ..We hypothesized that this higher than expected rate of lymphedema may be secondary to disruption of arm lymphatics during an SLNB procedure...
  68. pmc Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
    Li Chen
    Program of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 189:417-24. 2010
    ..we show that Tbx1 is not required for lymphatic EC differentiation; rather, it is required for the growth and maintenance of lymphatic vessels. Our findings reveal a novel pathway for the development of the lymphatic vessel network.
  69. ncbi Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors
    Laura Rubbia-Brandt
    Services of Clinical Pathology, Gastroenterology and Hepatology, and Digestive Surgery, Geneva University Hospital, Geneva, Switzerland
    Clin Cancer Res 10:6919-28. 2004
    ..We found that both benign and malignant pancreatic endocrine tumors contain intratumoral lymphatic vessels. Lymphatic vessel density was related to the size of the tumor in benign tumors and to the presence of liver ..
  70. pmc Intralobular pulmonary lymphatic distribution in normal human lung using D2-40 antipodoplanin immunostaining
    Marianne Kambouchner
    Department of Pathology, Hopital Avicenne, Bobigny, France
    J Histochem Cytochem 57:643-8. 2009
    ..for limited areas close to respiratory bronchioles or their satellite arteries, there is no evidence of lymphatic vessels deep in the pulmonary lobule...
  71. pmc Clinicopathological correlation analysis of (lymph) angiogenesis and corneal graft rejection
    Yongxin Zheng
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:1694-700. 2011
    ..To investigate the relationship of (lymph) angiogenesis and survival time of human cornea grafts...
  72. pmc Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium
    Giorgia Jurisic
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Exp Cell Res 316:2982-92. 2010
    ..Thy1 was also strongly expressed by tumor-associated lymphatic vessels, as evaluated in a B16 melanoma footpad model in mice...
  73. pmc The use of LYVE-1 antibody for detecting lymphatic involvement in patients with malignant melanoma of known sentinel node status
    D Sahni
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas s Hospital, London SE1 7EH, UK
    J Clin Pathol 58:715-21. 2005
    ..The LYVE-1 lymphatic marker offers the possibility of studying lymphangiogenesis and tumour metastasis within the primary excision...
  74. doi Preliminary evidence of the presence of lymphatic vessels immunoreactive for D2-40 and Prox-1 in human pterygium
    Anca Maria Cimpean
    Department of Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Oncol Rep 26:1111-3. 2011
    ..No data are available concerning the presence of lymphatic vessels in this pathological condition...
  75. doi Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
    Anna Katharina Meinecke
    Institut fur Physiologie, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Blood 119:5931-42. 2012
    ..b>Lymphatic vessels have been implicated with the development of pulmonary fibrosis, but the role of the lymphatic vasculature ..
  76. pmc Lymphatic development
    Matthew G Butler
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 87:222-31. 2009
    ..This review focuses on the mechanisms regulating development of the lymphatic vasculature during embryogenesis...
  77. pmc Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration
    Hwee Ying Lim
    Department of Microbiology, Immunology Programme, Yoon Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore
    Am J Pathol 175:1328-37. 2009
    b>Lymphatic vessels are essential for lipid absorption and transport...
  78. ncbi Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  79. ncbi Genes tell lymphatics to sprout or not
    Judah Folkman
    Nat Immunol 5:11-2. 2004
  80. doi Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos
    Masanori Hirashima
    The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dev Biol 316:149-59. 2008
    ..into the embryonic forelimb showed defective lymphatic drainage function and obstruction in collecting lymphatic vessels of Aspp1(-/-) embryos...
  81. pmc Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
    Pipsa Saharinen
    Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN 00014, Finland
    Genes Dev 24:875-80. 2010
    ..Targeted disruption of Clp24 in mice led to enlarged lymphatic vessels having an abnormal smooth muscle cell coating...
  82. doi The location of lymphangiogenesis is an independent prognostic factor in rectal cancers with or without preoperative radiotherapy
    A Holmqvist
    Department of Medical Oncology, Institute of Clinical and Experimental Medicine, Linkoping University, Sweden
    Ann Oncol 21:512-7. 2010
    ....
  83. doi Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells
    Wei Zhuo
    National Engineering Laboratory for Anti Tumour Protein Therapeutics, Tsinghua University, Beijing, China
    J Pathol 222:249-60. 2010
    ....
  84. doi Lymphatic vessel density as prognostic marker in esophageal adenocarcinoma
    Reda S Saad
    Department of Pathology, Allegheny General Hospital
    Am J Clin Pathol 131:92-8. 2009
    ..Our study showed that angiogenesis and lymphangiogenesis have important roles in the progression of esophageal adenocarcinoma...
  85. ncbi The lymphatic vasculature: recent progress and paradigms
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Cell Dev Biol 21:457-83. 2005
    ..This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis...
  86. doi A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: development, characterization, and applications
    Carmen Bonvin
    Institute of Bioengineering, School of Life Sciences LMBM Station 15, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Biotechnol Bioeng 105:982-91. 2010
    ..Therefore, this device is useful for studies of capillary morphogenesis, cell migration, contractile cells like fibroblasts, and multicellular cultures, all under interstitial flow...
  87. doi Tumor lymphatics
    Jonathan Sleeman
    University of Heidelberg, Medical Faculty Mannheim, Ludolf Krehl Str 13 17, D 68167 Mannheim, Germany
    Semin Cancer Biol 19:285-97. 2009
    In this article we survey more than three centuries of observation and research into tumor-associated lymphatic vessels, and their role in the metastatic spread of cancer...
  88. pmc Regulation of lymphatic-blood vessel separation by endothelial Rac1
    Gabriela D'Amico
    Adhesion and Angiogenesis Laboratory, Institute of Cancer and Cancer Research UK, Bart s and the London Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Development 136:4043-53. 2009
    ..Our studies identify Rac1 as a crucial part of the migratory machinery required for endothelial cells to separate and form lymphatic vasculature...
  89. doi Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up
    Rabab A A Mohammed
    Department of Clinical Oncology, University of Nottingham, UK
    J Pathol 223:358-65. 2011
    ..VI status should be included routinely in breast cancer staging systems...
  90. pmc Differential distribution of blood and lymphatic vessels in the murine cornea
    Tatiana Ecoiffier
    Center for Eye Disease and Development, School of Optometry, University of California, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 51:2436-40. 2010
    ..The purpose of this study was to investigate this question and to examine whether and how the distribution patterns change during corneal inflammatory lymphangiogenesis (LG) and hemangiogenesis (HG)...
  91. doi Cellular-level characterization of lymph vessels in live, unlabeled corneas by in vivo confocal microscopy
    Beatrice Bourghardt Peebo
    Department of Ophthalmology, Linkoping University Hospital, Linkoping, Sweden
    Invest Ophthalmol Vis Sci 51:830-5. 2010
    ..To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas...
  92. doi Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro
    Benjamin Vigl
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    Exp Cell Res 315:336-47. 2009
    b>Lymphatic vessels play an important role in tissue fluid homeostasis, intestinal fat absorption and immunosurveillance. Furthermore, they are involved in pathologic conditions, such as tumor cell metastasis and chronic inflammation...
  93. pmc Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Development 137:363-72. 2010
    ....
  94. doi Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis
    Laura Carramolino
    Departamento de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain
    Circ Res 106:1197-201. 2010
    ..However, the basis for these defects has remained unknown because the mutations characterized affect more than one blood lineage...
  95. pmc Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Pathol 177:3202-14. 2010
    ..The use of these strategies may represent a novel means of preventing lymphedema after lymph node resection...
  96. pmc Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..EHC T-syn(-/-) mice exhibited embryonic and neonatal lethality associated with disorganized and blood-filled lymphatic vessels. Bone marrow transplantation and EC C1galt1 transgene rescue demonstrated that lymphangiogenesis ..
  97. pmc Emilin1 deficiency causes structural and functional defects of lymphatic vasculature
    Carla Danussi
    Division of Experimental Oncology 2, Department of Molecular Oncology and Translational Research, CRO IRCCS, Aviano, Pordenone, Italy
    Mol Cell Biol 28:4026-39. 2008
    ..an elastic microfibril-associated protein, is highly expressed by LECs in vitro and colocalizes with lymphatic vessels in several mouse tissues...
  98. doi Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer
    Bong Hyun Jeon
    National Research Laboratory of Vascular Biology and Biomedical Research Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Cancer Res 68:1100-9. 2008
    ..Here, we identified and characterized peritoneal lymphatic vessels in OVCA mice, a model generated by implantation of human OVCA cells into athymic nude mice...
  99. ncbi Role of lymphangiogenic factors in tumor metastasis
    Yulong He
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, POB 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Biochim Biophys Acta 1654:3-12. 2004
    Nearly four centuries after the discovery of lymphatic vessels, the molecular mechanisms underlying their development are beginning to be elucidated...
  100. ncbi Lymphatic vessel density, microvessel density and lymphangiogenic growth factor expression in colorectal cancer
    S E Duff
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Colorectal Dis 9:793-800. 2007
    ..The aim of this study was to quantify LVD and MVD in colorectal cancer, determine the relationship between LVD, MVD and clinicopathological variables and examine the relationship between LVD and tumour expression of VEGF-C and VEGF-D...
  101. doi Lymphangiogenesis: in vitro and in vivo models
    Françoise Bruyére
    Laboratory of Tumor and Developmental Biology, GIGA Cancer, University of Liege, Tour de Pathologie, CHU B23 Sart Tilman, Ave de l Hôpital 3, Liege, Belgium
    FASEB J 24:8-21. 2010
    Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft rejection...

Research Grants87

  1. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2010
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  2. Angiopoietins in airway vascular leak and angiogenesis
    Donald M McDonald; Fiscal Year: 2010
    This project will examine the diverse actions of angiopoietins on airway blood vessels and lymphatic vessels with the goal of understanding underlying mechanisms of airway inflammation and developing new treatment strategies...
  3. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
    ..their clearance is thought to be emigration from the inflammatory focus to the draining lymph node through lymphatic vessels. This model for the fate of monocyte-derived cells during acute inflammation is, however, based on limited ..
  4. Corneal Lymphatics & Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2011
    ..More importantly, we have discovered the genesis of lymphatic vessels in the cornea proper in response to HSV-1 infection operates thru a unique pathway distinct from what has ..
  5. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2010
    Absence of blood and lymphatic vessels in the normal cornea is essential for optical clarity and optimal vision...
  6. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..Preliminary data indicates that Foxc2+/- mice have highly abnormal lymphatic vessels and lymph nodes analogous to those in patient's with LD...
  7. Mechanisms of VEGF-A regulated tumor lymphangiogenesis
    Sophia Ran; Fiscal Year: 2007
    ..The prerequisite for this process is generation of new lymphatic vessels accessible to tumor cells. The formation of new lymphatic vessels, i.e...
  8. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2005
    ..Preliminary data indicates that Foxc2+/- mice have highly abnormal lymphatic vessels and lymph nodes analogous to those in patient's with LD...
  9. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
    ..Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol homeostasis...
  10. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2010
    ..function of VEGF-C is distinctly different from its known paracrine function of inducing the growth of new lymphatic vessels. We believe that by protecting the prostate cancer cells from stress-induced apoptosis, VEGF-C promotes ..
  11. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..The goal of Aim #1 is to define the abnormalities of lymphatic vessels in chronic airway inflammation, identify the driving factors, and determine the consequences and ..
  12. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The high pressure pushes fluid out of the capillaries faster that the lymphatic vessels can drain the fluid from the lungs...
  13. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Robert Drake; Fiscal Year: 2001
    ..The high pressure pushes fluid out of the capillaries faster that the lymphatic vessels can drain the fluid from the lungs...
  14. TNF family members for lymph angiogenesis and lymph node hypertrophy
    Yang Xin Fu; Fiscal Year: 2010
    Rapid development of lymphatic vessels (LV) and high endothelial venules (HEV) in peripheral tissues leads to hypertrophy of draining lymph nodes (LN) during inflammation/vaccination, but the molecular mechanism regulating LN ..
  15. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas Vlahakis; Fiscal Year: 2007
    ..such as lymphedema are clearly associated with genetic abnormalities of the VEGF control system for the lymphatic vessels. By addressing the Specific Aims of this proposal the poorly understood and appreciated biology of pulmonary ..
  16. VPF/VEGF IN NORMAL AND NEOPLASTIC SKIN ANGIOGENESIS
    Michael Detmar; Fiscal Year: 2003
    ..b>Lymphatic vessels are the predominant path for the metastatic spread of skin cancers, and we found that VEGF-C, although ..
  17. VPF/VEGF IN NORMAL AND NEOPLASTIC SKIN ANGIOGENESIS
    Michael Detmar; Fiscal Year: 2001
    ..b>Lymphatic vessels are the predominant path for the metastatic spread of skin cancers, and we found that VEGF-C, although ..
  18. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2009
    This project will examine the diverse actions of angiopoietins on airway blood vessels and lymphatic vessels with the goal of understanding underlying mechanisms of airway inflammation and developing new treatment strategies...
  19. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2007
    This project will examine the diverse actions of angiopoietins on airway blood vessels and lymphatic vessels with the goal of understanding underlying mechanisms of airway inflammation and developing new treatment strategies...
  20. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  21. Endoscopic Detection of Fluorescein for Sentinel Lymph Node Biopsy
    James McGreevy; Fiscal Year: 2007
    ..The fluorescence endoscopy instrumentation will be used to define the lymphatic vessels and to find the sentinel lymph node with minimally-invasive surgical techniques...
  22. Physiological Basis of Vascular Contractility
    David Zawieja; Fiscal Year: 2006
    Hydrodynamic forces are important intrinsic regulators of contractile function for arterial, venous and lymphatic vessels. All 3 vessel types react to changes in transmural pressure and luminal shear stress, but their responses differ ..
  23. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2011
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  24. Short-term mesenteric lymphatic adaptation to trauma-related intestinal edema
    Emily Wilson; Fiscal Year: 2010
    ..When interstitial pressure exceeds central venous pressure, lymphatic vessels can act as conduit vessels, passively transporting lymph down a pressure gradient...
  25. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2010
    ..The model utilizes RFP-labeled human pancreatic cancer cells and monoclonal anti-LYVE1 antibody to label lymphatic vessels in order to image lymphatic trafficking of tumor cells...
  26. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2010
    ..The model utilizes RFP-labeled human pancreatic cancer cells and monoclonal anti-LYVE1 antibody to label lymphatic vessels in order to image lymphatic trafficking of tumor cells...
  27. The Lymphatic System in the Primate corpus Luteum
    Fuhua Xu; Fiscal Year: 2007
    ..1 - To investigate the presence, localization, and dynamics of lymphatic vessels in the primate ovary, specifically in the CL throughout the luteal lifespan of the menstrual cycle...
  28. VPF/VEGF IN NORMAL AND NEOPLASTIC SKIN ANGIOGENESIS
    Michael Detmar; Fiscal Year: 2007
    ..is to characterize the molecular mechanisms that regulate the generation and function of blood vessels and lymphatic vessels in the skin...
  29. Fox Transcription Factors in Vascular Development
    Tsutomu Kume; Fiscal Year: 2009
    ..mechanisms of congenital cardiovascular anomalies, including arteriovenous malformations and abnormal lymphatic vessels. The proposed studies will significantly contribute to a better understanding of the causes of congenital ..
  30. NF-kB mediated induction of VEGFR-3 and new lymphatic vessels in breast cancer
    Sophia Ran; Fiscal Year: 2010
    ..We propose to delineate the molecular events that associate tumor inflammation, the formation of new lymphatic vessels and lymphatic metastasis...
  31. Control of lymphatic vessel growth and development by platelets
    Mark L Kahn; Fiscal Year: 2010
    Separation of blood and lymphatic vessels requires the hematopoietic signaling proteins SYK and SLP-76, but how blood cells perform this function is not known...
  32. US with Submicron Bubbles for Sentinel Node Detection
    Erik Wisner; Fiscal Year: 2004
    ..Advantages are that nodes and associated afferent lymphatic vessels can be visualized directly and noninvasively in real-time, logistical and radiation safety issues associated ..
  33. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..endothelial cells now provides an entirely new dimension to identifying and understanding lymphatic flow and lymphatic vessels in cancer metastasis...
  34. Influences of Lymph Flow on the Lymphatic Pump
    David Zawieja; Fiscal Year: 2007
    ..of the amplitude and frequency of contractions induced by a controlled increase in imposed flow in isolated lymphatic vessels. Others have shown increases in the contraction frequency, reductions in lymphatic diameters and decreases ..