lymphatic vessels

Summary

Summary: Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.

Top Publications

  1. doi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
  2. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
  3. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
  4. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
  5. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
  6. doi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
  7. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
  8. ncbi Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004
  9. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
  10. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007

Detail Information

Publications310 found, 100 shown here

  1. doi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
    The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a ..
  2. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes...
  3. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    b>Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema...
  4. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    ..known that both macrophages and blood vessels are critical to wound repair, the role of wound-associated lymphatic vessels has not been well investigated...
  5. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
    ..Whereas little or no HGF-R expression was detected by lymphatic vessels of normal tissues, HGF-R was strongly expressed by regenerating lymphatic endothelium during tissue repair ..
  6. doi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
    ..Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth...
  7. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    Lymphangiogenesis is associated with human and murine cancer metastasis, suggesting that lymphatic vessels are important for tumor dissemination...
  8. ncbi Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004
    ....
  9. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
    ....
  10. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
    Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates...
  11. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
    ..Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction...
  12. pmc Lymphatic vascular morphogenesis in development, physiology, and disease
    Stefan Schulte-Merker
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
    J Cell Biol 193:607-18. 2011
    ..Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation...
  13. doi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  14. ncbi Dendritic-cell trafficking to lymph nodes through lymphatic vessels
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, New York 10029, USA
    Nat Rev Immunol 5:617-28. 2005
    ..the presentation of these antigens requires that the dendritic cells migrate to draining lymph nodes through lymphatic vessels. In this article, we review important aspects of what is known about dendritic-cell trafficking into and ..
  15. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
    ....
  16. pmc Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    Eleni Bazigou
    Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 17:175-86. 2009
    ..Our findings reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects...
  17. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..the origins of the lymphatic system in the embryo, and the mechanisms that direct growth of the network of lymphatic vessels, remain unclear...
  18. doi The lymphatic vasculature in disease
    Kari Alitalo
    Molecular Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Nat Med 17:1371-80. 2011
    Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way conduit for tissue fluid and leukocytes...
  19. pmc Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature
    R Sathish Srinivasan
    Department of Genetics and Tumor Cell Biology, St Jude Children s Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 21:2422-32. 2007
    ..We conclude that the mammalian lymphatic system has a solely venous origin...
  20. doi Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
    ..The heterogeneity of expression of markers in both blood and lymphatic vessels reflects underlying differences in the phenotype of endothelial cells...
  21. pmc Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways
    Li Chin Yao
    Department of Anatomy, University of California, 513 Parnassus Ave, Room S1363, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:1525-41. 2010
    ..We suggest that lymphatic remodeling that persists after the initial inflammatory response has resolved may influence subsequent inflammatory episodes in clinical situations...
  22. pmc Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
    Holger Pflicke
    Max Planck Institute of Biochemistry, Hofschneider Group Leukocyte Migration, 82152 Martinsried, Germany
    J Exp Med 206:2925-35. 2009
    ..rates, leukocyte extravasation from the blood circulation is well investigated, whereas intravasation into lymphatic vessels has hardly been studied...
  23. doi Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution
    Raghu P Kataru
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Guseong Dong, Daejeon, Korea
    Blood 113:5650-9. 2009
    Using a bacterial pathogen-induced acute inflammation model in the skin, we defined the roles of local lymphatic vessels and draining lymph nodes (DLNs) in antigen clearance and inflammation resolution...
  24. doi Molecular control of lymphatic metastasis
    Marc G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Ann N Y Acad Sci 1131:225-34. 2008
    ..Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis...
  25. pmc Morphometric analysis of intralobular, interlobular and pleural lymphatics in normal human lung
    Francesca Sozio
    Department of Neuroscience, Molecular Medicine Section, University of Siena, Siena, Italy
    J Anat 220:396-404. 2012
    ..specific for lymphatic endothelium has led to the observation that, contrary to previous assumptions, human lymphatic vessels extend deep inside the pulmonary lobule in association with bronchioles, intralobular arterioles or small ..
  26. pmc Intralobular pulmonary lymphatic distribution in normal human lung using D2-40 antipodoplanin immunostaining
    Marianne Kambouchner
    Department of Pathology, Hopital Avicenne, Bobigny, France
    J Histochem Cytochem 57:643-8. 2009
    ..for limited areas close to respiratory bronchioles or their satellite arteries, there is no evidence of lymphatic vessels deep in the pulmonary lobule...
  27. pmc CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 171:1249-57. 2007
    ..was highly expressed on migrated cutaneous DCs and that its ligand, CXCL12, was detected in the LYVE-1(+) lymphatic vessels in the skin...
  28. doi Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patterns
    Takumi Yamamoto
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Plast Reconstr Surg 127:1979-86. 2011
    ..The purpose of this study was to describe, analyze, and classify characteristic indocyanine green lymphography findings to uniformly guide surgical management of lymphedema using this modality...
  29. doi Intratumoral as well as peritumoral lymphatic vessel invasion correlates with lymph node metastasis and unfavourable outcome in colorectal cancer
    Mei Lin
    Laboratory Medicine, Qingdao Municipal Hospital, Qingdao, China
    Clin Exp Metastasis 27:123-32. 2010
    ..The results of this study demonstrated that intratumoral as well as peritumoral LVI was associated with lymph node metastasis and adverse outcome in colorectal cancer...
  30. pmc Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications
    Hong Feng Gou
    Center of Medical Oncology, West China Hospital, Sichuan University, PR China
    J Exp Clin Cancer Res 30:14. 2011
    ..This study aims to test the expression of COX-2 and VEGF-C in human gastric cancer, and to analyze the correlation with lymphatic vessel density (LVD), clinicopathologic features and survival prognosis...
  31. pmc Mechanoinduction of lymph vessel expansion
    Lara Planas-Paz
    Institute of Metabolic Physiology, Heinrich Heine University, Dusseldorf, Germany
    EMBO J 31:788-804. 2012
    ..Thus, we propose a new and physiologically relevant mode of VEGFR3 activation, which is based on mechanotransduction and is essential for normal development and fluid homeostasis in a mammalian embryo...
  32. pmc Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span
    Riccardo E Nisato
    Department of Morphology, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Am J Pathol 165:11-24. 2004
    ..The production and characterization of hTERT-HDLEC will facilitate the study of the properties of lymphatic endothelium in vitro...
  33. doi Lymphatic vessels in osteoarthritic human knees
    D A Walsh
    Arthritis Research UK Pain Centre, Academic Rheumatology, University of Nottingham, City Hospital, Nottingham, UK
    Osteoarthritis Cartilage 20:405-12. 2012
    The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely...
  34. ncbi Accurate assessment of lymph vessel tumor emboli in invasive ductal carcinoma of the breast according to tumor areas, and their prognostic significance
    Chisako Yamauchi
    Pathology Division, National Cancer Center Research Institute East, Kashiwa, Chiba, 277 0882, Japan
    Hum Pathol 38:247-59. 2007
    ....
  35. pmc Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice
    Momina Mirza
    Department of Women s and Children s Health, Karolinska Institute and University Hospital, Stockholm, Sweden
    PLoS ONE 7:e37523. 2012
    ..CAR is not expressed in vascular endothelial cells but was recently detected in neonatal lymphatic vessels, suggesting that CAR could play a role in the development of the lymphatic system...
  36. pmc Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage
    Susan N Thomas
    Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology, Lausanne EPFL, 1015 Lausanne, Switzerland
    J Immunol 189:2181-90. 2012
    b>Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood...
  37. doi Peritumoral lymphatic microvessel density associated with tumor progression and poor prognosis in gastric carcinoma
    Ugur Coskun
    Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey
    J Surg Res 164:110-5. 2010
    ..The aim of the present study was to evaluate the clinical significance of lymphangiogenesis and its regulation in gastric carcinomas...
  38. doi Role of lymphatic vessels in tumor immunity: passive conduits or active participants?
    Amanda W Lund
    Institute of Bioengineering and Swiss Institute of Experimental Cancer Research, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Mammary Gland Biol Neoplasia 15:341-52. 2010
    ..This review presents emerging evidence that lymphatic vessels are active modulators of immunity, perhaps fine-tuning the response to adjust the balance between peripheral ..
  39. ncbi Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 19:392-8. 2006
    ..b>Lymphatic vessels were detected by immunohistochemical stain using an antibody specific for the lymphatic endothelial cells (..
  40. pmc Lymphovascular invasion in colorectal cancer: an interobserver variability study
    Elizabeth I Harris
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Surg Pathol 32:1816-21. 2008
    ..This study was undertaken to examine such interobserver variability, and we hypothesized that the use of immunohistochemical markers for vascular and lymphatic channels could improve interobserver agreement...
  41. doi MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vessels
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
    Microvasc Res 76:42-5. 2008
    To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels.
  42. pmc Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels
    Philipp Steven
    Department of Ophthalmology, University of Lubeck, Lubeck, Germany
    PLoS ONE 6:e26253. 2011
    The role of lymphatic vessels in tissue and organ transplantation as well as in tumor growth and metastasis has drawn great attention in recent years.
  43. doi Fibrosis is a key inhibitor of lymphatic regeneration
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 124:438-50. 2009
    ..The purpose of these experiments was therefore to evaluate lymphatic regeneration in the setting of variable soft-tissue fibrosis...
  44. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012
    ..Third, lymphatic vessels emerge by a combination of mechanisms including sprouting from the lymph sacs and direct delamination of ..
  45. pmc Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature
    Jan Kazenwadel
    Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, 5000 SA, Australia
    Blood 119:1283-91. 2012
    ..Primary lymphedema occurs as a result of aberrations in the development and/or function of lymphatic vessels, spurring us to investigate whether GATA2 plays a role in the lymphatic vasculature...
  46. pmc Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  47. pmc Induction of lymphatic endothelial cell differentiation in embryoid bodies
    Ruediger Liersch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Blood 107:1214-6. 2006
    ..Our results reveal, for the first time, that ES cells can differentiate into lymphatic endothelial cells, and they identify the EB assay as a powerful new tool to dissect the molecular mechanisms that control lymphatic vessel formation...
  48. pmc Combined blockade of VEGFR-2 and VEGFR-3 inhibits inflammatory lymphangiogenesis in early and middle stages
    Don Yuen
    Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 52:2593-7. 2011
    ..The purpose of this study was to investigate whether there is a time window for therapeutic intervention of corneal LG and whether a combined blockade of VEGFR-2 and VEGFR-3 effectively suppresses early-, middle-, or late-stage LG...
  49. ncbi Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome
    Susan L Dagenais
    Department of Human Genetics, University of Michigan, 4909 Buhl, Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Gene Expr Patterns 4:611-9. 2004
    ....
  50. ncbi Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
    Piotr Religa
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsvag 16, 171 77 Stockholm, Sweden
    Blood 106:4184-90. 2005
    ..green fluorescent protein (EGFP)-positive donor bone marrow cells, CEPCs are present in the newly formed lymphatic vessels. Depletion of bone marrow cells by irradiation remarkably suppressed lymphangiogenesis in corneas implanted ..
  51. doi Interaction of tumor cells and lymphatic vessels in cancer progression
    A Alitalo
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Oncogene 31:4499-508. 2012
    ..Growth of new lymphatic vessels, lymphangiogenesis, is activated in cancer and inflammation, but is largely inactive in normal physiology, ..
  52. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009
    ..We conclude that TNF-alpha is a strong candidate for a mediator that drives blood vessel remodeling and lymphangiogenesis in inflammation...
  53. pmc Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development
    Fei Zhou
    Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China
    Am J Pathol 177:2124-33. 2010
    ..There was an uncharacteristic enlargement of collecting lymphatic vessels, and further analysis showed that smooth muscle cell coverage of collecting lymphatic vessels became much ..
  54. ncbi Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread
    Martin Schneider
    Department of General Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 28:883-90. 2006
    Treatment options for ductal adenocarcinoma of the pancreas are limited by early lymphatic spread, but the lymphatic vessels in pancreatic carcinoma have not been studied to date...
  55. pmc First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours
    I Van der Auwera
    Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp University Hospital Antwerp, Edegem 2650, Belgium
    Br J Cancer 95:1611-25. 2006
    ..For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed...
  56. doi CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
    Frank L Bos
    Hubrecht Institute KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Circ Res 109:486-91. 2011
    ..Insight into the molecular role of CCBE1 is completely lacking, and mouse models for the disease do not exist...
  57. ncbi Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation
    Margaret Thompson
    Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Ann Surg Oncol 14:1890-5. 2007
    ..Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema...
  58. pmc Targeting lymphangiogenesis to prevent tumour metastasis
    M G Achen
    Ludwig Institute for Cancer Research, Post Office Box 2008 Royal Melbourne Hospital, Victoria 3050, Australia
    Br J Cancer 94:1355-60. 2006
    ..animal models of cancer and clinicopathological analyses of human tumours suggest that the growth of lymphatic vessels (lymphangiogenesis) in or nearby tumours is associated with the metastatic spread of cancer...
  59. pmc Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..EHC T-syn(-/-) mice exhibited embryonic and neonatal lethality associated with disorganized and blood-filled lymphatic vessels. Bone marrow transplantation and EC C1galt1 transgene rescue demonstrated that lymphangiogenesis ..
  60. pmc Netrin-4 induces lymphangiogenesis in vivo
    Frederic Larrieu-Lahargue
    Program in Molecular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Blood 115:5418-26. 2010
    ..Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation...
  61. ncbi Synchrony of high endothelial venules and lymphatic vessels revealed by immunization
    Shan Liao
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:3369-79. 2006
    ....
  62. doi Tumor metastasis and the lymphatic vasculature
    Jonathan P Sleeman
    Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Mannheim, Germany
    Int J Cancer 125:2747-56. 2009
    Tumor-associated lymphatic vessels act as a conduit by which disseminating tumor cells access regional lymph nodes and form metastases there...
  63. doi Hyaluronic acid-quantum dot conjugates for in vivo lymphatic vessel imaging
    Suk Ho Bhang
    Department of Bioengineering, Hanyang University, Seoul 133 791, Korea
    ACS Nano 3:1389-98. 2009
    ..The conjugates are also demonstrated for the fluorescence staining capability for lymphatic vessels in vitro and in vivo...
  64. doi Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 184:535-9. 2010
    The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation...
  65. pmc An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, and Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham Medical School, UK
    J Exp Med 203:2763-77. 2006
    ..How such an exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels are unknown...
  66. pmc The lymphatic system in health and disease
    Leah N Cueni
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Lymphat Res Biol 6:109-22. 2008
    ..The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of in vitro and in vivo models to study various ..
  67. ncbi Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia
    Rainer Kunstfeld
    Cutaneous Biology Research Center, Massachusetts General Hospital, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Blood 104:1048-57. 2004
    ..They also indicate that inhibition of VEGF-A bioactivity might be a new approach to anti-inflammatory therapy...
  68. doi VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium
    Tara Karnezis
    Tumour Angiogenesis Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Cancer Cell 21:181-95. 2012
    ..Collecting lymphatics therefore play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread...
  69. pmc Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse
    Inho Choi
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 117:362-5. 2011
    ..other Prox1-expressing organs, and enabled us to conveniently visualize detailed structure and morphology of lymphatic vessels and networks throughout development...
  70. pmc FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
    Camilla Norrmen
    Molecular Cancer Biology Program, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Cell Biol 185:439-57. 2009
    ..of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process...
  71. pmc Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Am J Pathol 171:361-72. 2007
    ..In contrast, the role of integrins in lymphangiogenesis, ie, the outgrowth of new from pre-existing lymphatic vessels, has so far been unclear...
  72. pmc Preclinical lymphatic imaging
    Fan Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:599-612. 2011
    Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of lymphangiogenesis and lymphatic spread of ..
  73. doi Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients
    Annika Algars
    Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland
    Int J Cancer 131:864-73. 2012
    ..Here, we elucidated the prognostic significance of lymphatic vessels, different types of macrophages and the balance between different macrophage types in colorectal cancer...
  74. ncbi Choose your fate: artery, vein or lymphatic vessel?
    Natasha L Harvey
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA
    Curr Opin Genet Dev 14:499-505. 2004
    ..Their combined actions are required for the specification and development of the arteries, veins and lymphatic vessels; vascular networks that are vital for embryonic and adult survival, and whose malfunction causes major ..
  75. pmc Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium
    Giorgia Jurisic
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Exp Cell Res 316:2982-92. 2010
    ..Thy1 was also strongly expressed by tumor-associated lymphatic vessels, as evaluated in a B16 melanoma footpad model in mice...
  76. doi Lymphatic vessel invasion is a significant prognostic indicator in stage IA lung adenocarcinoma
    Kazuhito Funai
    First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann Surg Oncol 18:2968-72. 2011
    ..The aim of this retrospective study was to evaluate the prognostic influence of lymphatic vessel invasion (LVI) in stage IA adenocarcinoma patients...
  77. pmc Blood flow reprograms lymphatic vessels to blood vessels
    Chiu Yu Chen
    Department of Medicine and Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:2006-17. 2012
    ..protein of 76 kDa (SLP76) resulted in a vascular malformation that directed blood flow through mesenteric lymphatic vessels after birth in mice...
  78. ncbi Development of the lymphatic vascular system: a mystery unravels
    Young Kwon Hong
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Dev Dyn 231:462-73. 2004
    ....
  79. ncbi VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma
    Hironao Yasuoka
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    Mod Pathol 18:1127-33. 2005
    ..In conclusion, our findings indicate that VEGF-D expression and increased lymph vessel density may have an important role for lymph node metastasis in papillary thyroid carcinoma...
  80. doi Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis
    Kaori Harada
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 122:3923-30. 2009
    ..cells (BECs) into lymphatic endothelial cells (LECs), and subsequently in the maturation and maintenance of lymphatic vessels. However, the molecular mechanisms by which Prox1 elicits these functions remain to be elucidated...
  81. doi Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas
    Yasser M El-Gohary
    Arkadi M Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Am J Clin Pathol 129:578-86. 2008
    ..D2-40 detected more LVI than H&E- and CD31-detectable vascular invasion (18/48, 5/48, 11/48, respectively). Increased D2-40 detected LVI, and high CD31 microvessel counts showed significant adverse effect on survival status...
  82. pmc Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule
    Tarik Attout
    USM 307, Parasitologie comparée et modèles expérimentaux, Museum national d histoire naturelle, Paris, France
    PLoS ONE 4:e8234. 2009
    ..of macrophages were found to be positive for Lyve-1 and some were integrated into the endothelium of the lymphatic vessels, revealing their plasticity in the nodular micro-environment...
  83. doi Dilated lymphatic vessels in tufted angioma: a potential source of diagnostic confusion
    Mona Sadeghpour
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Dermatopathol 34:400-3. 2012
    ..The presence of lymphatic vessels suggestive of lymphangioma can occasionally be the predominant finding and cause diagnostic confusion...
  84. doi Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective study
    David W Chang
    Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Plast Reconstr Surg 126:752-8. 2010
    ..The purpose of this prospective study was to provide a preliminary analysis of lymphaticovenular bypass for the treatment of upper limb lymphedema in breast cancer patients...
  85. doi Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
    Benjamin M Hogan
    Hubrecht Institute KNAW and University Medical Centre, Utrecht, The Netherlands
    Nat Genet 41:396-8. 2009
    b>Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of ..
  86. doi Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis
    Tuomas Tammela
    Molecular Cancer Biology Laboratory, Faculty of Medicine Research Programs, Haartman Institute, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, POB 63 Haartmaninkatu 8, University of Helsinki, 00014 Helsinki, Finland
    Sci Transl Med 3:69ra11. 2011
    ..Tumor-associated lymphatic vessels are a key conduit for metastatic tumor cells, which typically first colonize the lymph nodes...
  87. ncbi Lymphatic vessels in cancer metastasis: bridging the gaps
    Ramin Shayan
    Angiogenesis Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Carcinogenesis 27:1729-38. 2006
    ..aims to summarize these contributions, in terms of the history, identification, structure and function of lymphatic vessels in cancer and the role they play in tumour metastasis...
  88. doi A low frequency of lymph node metastasis in clear-cell renal cell carcinoma is related to low lymphangiogenic activity
    Marcella M Baldewijns
    Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    BJU Int 103:1626-31. 2009
    ..To assess ongoing lymphangiogenesis in renal cell carcinoma (RCC) by histomorphometry and by quantifying mRNA expression levels of lymphangiogenesis-related factors...
  89. ncbi Alcian blue staining method to visualize bonghan threads inside large caliber lymphatic vessels and x-ray microtomography to reveal their microchannels
    Changhoon Lee
    Biomedical Physics Laboratory, FPRD, School of Physics and Astronomy, Seoul National University, Seoul, Korea
    Lymphat Res Biol 4:181-90. 2006
    Novel threadlike structures, so-called Bonghan threads, inside large caliber lymphatic vessels were recently observed by using the Janus Green B staining in the case of rabbits, and by using fluorescent magnetic nanoparticles for rats...
  90. pmc Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow
    Jie Li
    University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 65:130-8. 2013
    ..The aim of this study was to examine whether the efficacy of B cell depletion therapy is associated with restoration of lymphatic drainage due to removal of obstructing nodal B cells...
  91. pmc Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California, USA
    Proc Am Thorac Soc 8:504-7. 2011
    Blood vessels and lymphatic vessels in the respiratory tract play key roles in inflammation...
  92. doi Lymphoedematous variants of Kaposi's sarcoma
    L Pantanowitz
    J Eur Acad Dermatol Venereol 22:118-20. 2008
  93. doi Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles
    Annelii Ny
    Vesalius Research Center, VIB KU Leuven, Leuven, Belgium
    Blood 112:1740-9. 2008
    ..These findings document a critical role of VEGFR-3 in embryonic lymphatic development and function, and reveal a previously unrecognized modifier role of VEGF-D in the regulation of embryonic lymphangiogenesis in frog embryos...
  94. ncbi Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, the Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Circ Res 100:1468-75. 2007
    ..However, both chimeras induced a distinctly different pattern of lymphatic vessels when compared with VEGF-C...
  95. pmc Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Physiol Cell Physiol 299:C589-605. 2010
    ..Radiation therapy decreases lymphatic reserve by causing depletion of lymphatic vessels and LECs as well as promoting soft tissue fibrosis...
  96. doi Anatomic and functional evaluation of the lymphatics and lymph nodes in diagnosis of lymphatic circulation disorders with contrast magnetic resonance lymphangiography
    Ning Fei Liu
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Vasc Surg 49:980-7. 2009
    ..This study evaluated the anatomic and functional images of contrast MR lymphangiography in the diagnosis of limb lymphatic circulation disorders...
  97. pmc Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity
    Evisa Gjini
    Hubrecht Institute KNAW and University Medical Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Dis Model Mech 4:57-66. 2011
    ..Our study introduces an additional vertebrate model to study in vivo the function of Tie-2 in development and disease...
  98. pmc Apelin attenuates UVB-induced edema and inflammation by promoting vessel function
    Mika Sawane
    Shiseido Innovative Science Research Center, Yokohama, Japan
    Am J Pathol 179:2691-7. 2011
    ..endothelial cells mediates APJ regulation of blood vessel caliber size; however, the function of apelin in lymphatic vessels is unclear...
  99. pmc Nitric oxide formation by lymphatic bulb and valves is a major regulatory component of lymphatic pumping
    H Glenn Bohlen
    Department of Cellular and Integrative Physiology, Indiana University Medical School, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 301:H1897-906. 2011
    ..In effect, NO generation by the bulb area and its valves limits the pumped flow of the total lymphatic by lowering frequency and stroke volume of individual contractions...
  100. doi Axillary reverse mapping: mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy
    Cristiano Boneti
    Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Winthrop P Rockefeller Cancer Institute, Little Rock, AR, USA
    J Am Coll Surg 206:1038-42; discussion 1042-4. 2008
    ..We hypothesized that this higher than expected rate of lymphedema may be secondary to disruption of arm lymphatics during an SLNB procedure...
  101. ncbi Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors
    Laura Rubbia-Brandt
    Services of Clinical Pathology, Gastroenterology and Hepatology, and Digestive Surgery, Geneva University Hospital, Geneva, Switzerland
    Clin Cancer Res 10:6919-28. 2004
    ..We found that both benign and malignant pancreatic endocrine tumors contain intratumoral lymphatic vessels. Lymphatic vessel density was related to the size of the tumor in benign tumors and to the presence of liver ..

Research Grants72

  1. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol homeostasis...
  2. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..Trafficking of tumor and dendritic cells from peripheral lymphatic vessels to regional lymph nodes will be examined in mice bearing gene defects in lymphatic glycosaminoglycan ..
  3. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    ..Our preliminary data indicate that fully allogeneic murine lung grafts exhibit a decrease in the density of lymphatic vessels with acute rejection...
  4. Cellular Mechanisms of Lymphatic Muscle Contractility
    MICHAEL JOHN DAVIS; Fiscal Year: 2012
    ..We propose to test the hypothesis that expression of SM-B MHC, cTn-C and ?- TMstr enable collecting lymphatic vessels to undergo the rapid, phasic contractions and relaxations required for normal lymphatic pump function...
  5. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    ..Accumulation of fluid in the placental-fetal unit also suggests lymphatic vessels in the decidua have diminished capacity to remove excess fluid...
  6. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2013
    ..function of VEGF-C is distinctly different from its known paracrine function of inducing the growth of new lymphatic vessels. We believe that by protecting the prostate cancer cells from stress-induced apoptosis, VEGF-C promotes ..
  7. The Role of Galectins in Corneal Hem- and Lymphangiogenesis
    Noorjahan Panjwani; Fiscal Year: 2013
    ..In addition to blood vessels (BV), lymphatic vessels (LV) also play a key role in graft rejection and other ocular disorders provoked by immune response...
  8. Molecular Imaging of Metastatic Potential in SCCHN by Targeting VLA-4 and CXCR4
    Carolyn J Anderson; Fiscal Year: 2013
    ..Tumor lymphangiogenesis is the growth of new lymphatic vessels within the periphery of the tumor, and this has been correlated to the formation of lymph node metastases...
  9. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2012
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  10. Corneal Lymphatics &Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2013
    ..More importantly, we have discovered the genesis of lymphatic vessels in the cornea proper in response to HSV-1 infection operates thru a unique pathway distinct from what has ..
  11. The role of lymphatic contraction in inflammation and cancer metastasis
    Shan Liao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Initial lymphatic vessels collect interstitial fluid to create lymph...
  12. Lymphotoxin: Regulation and Biologic Function
    NANCY RUDDLE; Fiscal Year: 2009
    ..In the next years, regulation of lymphatic vessels (LVs) will be studied...
  13. Transcriptional control of chemokine receptors and naive T cell trafficking
    Eric Sebzda; Fiscal Year: 2013
    ..T cell migration is limited to a series of peripheral secondary lymphoid organs interconnected via blood and lymphatic vessels whereas activated effector T cells can escape this circulatory loop and enter peripheral tissues...
  14. Mechanisms of the Age-related Alterations in Lymphatic Pumping
    Anatoliy A Gashev; Fiscal Year: 2012
    ..The specific aims are: 1) To determine the age-related changes in the sensitivity of lymphatic vessels to transmural pressure and to evaluate their adaptive contractile reserves, 2) To determine the age-related ..
  15. Intratumoral genetic therapy for lung cancer
    Steven M Dubinett; Fiscal Year: 2013
    ..and constitutively expressed by high endothelial venules in lymph nodes and Peyer's patches and by lymphatic vessels, stromal cells in the spleen and appendix...
  16. Characterization of lymphatic contraction during infection
    Timothy P Padera; Fiscal Year: 2013
    ..Initial lymphatic vessels take up interstitial fluid to create lymph that is transported through collecting lymphatic vessels and ..
  17. The role of BMX in Lymphangiogenesis
    Dennis Jones; Fiscal Year: 2011
    ..It has recently become appreciated that creation of new lymphatic vessels can provide an escape route for cancer cells en route to other parts of the body...
  18. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2013
    ..The model utilizes RFP-labeled human pancreatic cancer cells and monoclonal anti-LYVE1 antibody to label lymphatic vessels in order to image lymphatic trafficking of tumor cells...
  19. TNF family members for lymph angiogenesis and lymph node hypertrophy
    Yang Xin Fu; Fiscal Year: 2013
    Rapid development of lymphatic vessels (LV) and high endothelial venules (HEV) in peripheral tissues leads to hypertrophy of draining lymph nodes (LN) during inflammation/vaccination, but the molecular mechanism regulating LN ..
  20. Lymphatic Microenvironment: Altering Cell Traffic by Targeting Glycans
    Mark M Fuster; Fiscal Year: 2013
    ..lymphatic glycan biosynthesis will alter the ability of dendritic cells or tumor cells to migrate toward lymphatic vessels and traffic to lymph nodes in a chemokine-dependent manner...
  21. NF-kB mediated induction of VEGFR-3 and new lymphatic vessels in breast cancer
    Sophia Ran; Fiscal Year: 2013
    ..We propose to delineate the molecular events that associate tumor inflammation, the formation of new lymphatic vessels and lymphatic metastasis...
  22. Role of CCBE1 in lymphangiogenesis
    DAVID RICHARD ENIS; Fiscal Year: 2013
    ..In this simplified system, we will incubate ccbe1 protein with cells isolated from human skin lymphatic vessels. We will carefully measure changes in cell growth, survival, and internal signaling.
  23. Failure of metabolite clearance in a model of multi-lacunar infarcts
    Maiken Nedergaard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Unlike all other organs, the brain and spinal cord lack lymphatic vessels. Traditional thought has averred that the brain - despite having the highest basal metabolic rate of any organ - can function ..
  24. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2013
    ..small interference RNAs, neutralizing antibodies, and knockout mice;and 3) investigate the cell origins of lymphatic vessels using cell type-specific gene-manipulated mice and live imaging techniques...
  25. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2013
    Absence of blood and lymphatic vessels in the normal cornea is essential for optical clarity and optimal vision...
  26. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas E Vlahakis; Fiscal Year: 2010
    ..such as lymphedema are clearly associated with genetic abnormalities of the VEGF control system for the lymphatic vessels. By addressing the Specific Aims of this proposal the poorly understood and appreciated biology of pulmonary ..
  27. Laser-facilitated delivery of malarial sporozoites from the skin to liver
    Mei X Wu; Fiscal Year: 2013
    ..of the skin, permitting relatively free movement of SPZs and their entry into the capillaries and lymphatic vessels in the dermis...
  28. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2013
    ..their clearance is thought to be emigration from the inflammatory focus to the draining lymph node through lymphatic vessels. This model for the fate of monocyte-derived cells during acute inflammation is, however, based on limited ..
  29. LYMPHOTOXIN AND LYMPHOID NEOGENESIS
    Nancy H Ruddle; Fiscal Year: 2010
    ..Results with a novel bimodal dendrimer that visualizes lymphatic vessels by magnetic resonance imaging (MRI) and fluorescence suggest that mice deficient in LT have defective LVs...
  30. Role of Neuropilin receptors in lymphangiogenesis
    ANNE CHRISTINE EICHMANN; Fiscal Year: 2013
    ..The absence of lymphatic vessels is lethal, and impaired lymphatic vessel development causes fluid and protein accumulation in the ..
  31. Therapeutic Lymphatic Collecting Vessel Regeneration by Directed Fluid Flow
    Jeremy Goldman; Fiscal Year: 2012
    ..a biodegradable conduit may serve as a bridge for lymphatic fluid transport and promote lymphangiogenesis of lymphatic vessels and whether NO-release from the conduit may increase lymphatic endothelial cell (LEC) migration and ..
  32. Molecular Targeting of Lymphatic Endothelial Receptors for Ligand-directed Imagin
    RENATA contact PASQUALINI; Fiscal Year: 2010
    ..More recently, the important role of lymphatic vessels in disease states such as tumor dissemination and metastasis has been recognized with the correlation of the ..
  33. Fox Transcription Factors in Vascular Development
    Tsutomu Kume; Fiscal Year: 2012
    ..mechanisms of congenital cardiovascular anomalies, including arteriovenous malformations and abnormal lymphatic vessels. The proposed studies will significantly contribute to a better understanding of the causes of congenital ..
  34. Sphingosine-1-phosphate in breast cancer progression and lymphangiogenesis
    Kazuaki Takabe; Fiscal Year: 2013
    ..of cancer cells into lymph nodes is also mediated by lymphangiogenesis, a process that generates new lymphatic vessels from pre-existing ones...
  35. Targeting Neuropilin 2 with Semaphorin 3F during Pancreatic Carcinoma Progression
    Diane Renee Bielenberg; Fiscal Year: 2012
    ..the spread of malignant tumor cells from one site in the body to another, through blood vessels and lymphatic vessels. Pancreatic adeno-carcinoma is a devastating disease with only a 4% 5-year survival rate due to the lack of ..
  36. Protein-glycan Interactions in the Vascular System
    Lijun Xia; Fiscal Year: 2013
    ..Project 3 studies how the 0-glycoprotein podoplanin maintains separated blood and lymphatic vessels, how mixing of blood and lymphatic vessels contributes to disease, and how 0-glycosylation regulates the ..
  37. Regulation of Venous and Lymphatic Identity by Chromatin-Remodeling
    Courtney T Griffin; Fiscal Year: 2013
    ..and postnatal vascular pathologies, such as those that arise from misspecification of blood and lymphatic vessels. The objective of this proposal is to understand how the chromatin-remodeling enzymes BRG1 and CHD4 ..
  38. Doppler Optical Frequency Domain Imaging Instrument
    Dai Fukumura; Fiscal Year: 2010
    ..Furthermore, with Doppler OFDI we will be able to monitor changes in tumor associated lymphatic vessels and changes in tumor tissue viability...
  39. Integrated Multi-scale Adhesive Dynamics Modeling of T-lymphocyte Homing
    Daniel A Hammer; Fiscal Year: 2013
    ..It has been established that lymphocyte trafficking from the blood stream and the lymphatic vessels into tissues is controlled by molecular "zip-codes" that identify the location where lymphocytes need to ..
  40. RASA1-mediated control of lymphatic vessel growth and function
    Philip D King; Fiscal Year: 2012
    ..with the blood vascular system, the molecular mechanisms involved in the growth and development of lymphatic vessels in mammals remain poorly defined...
  41. Effects of Lymphangiogenesis Blockade on Skin Allograft Rejection
    GILLES A BENICHOU; Fiscal Year: 2013
    ..studies performed in the 1960's by Barker and Billingham have demonstrated the key role of afferent lymphatic vessels in the rejection of skin allografts...
  42. Engineered fibrillar matrices to study directed cell migration
    Brendon M Baker; Fiscal Year: 2013
    ..These cells then migrate through the stroma until they reach blood or lymphatic vessels and intravasate, thereby gaining access to other organ systems...
  43. Lymphatic endothelial cells as inducers of systemic peripheral tolerance
    Victor H Engelhard; Fiscal Year: 2013
    ..In Aim 3 we will define the mechanisms by which LEC that reside in LN, as opposed to those in tissue lymphatic vessels, are able to induce tolerance based on their expression of peripheral tissue Ags and a set of ..
  44. Evolving Microenvironments in Airway Inflammation
    George H Caughey; Fiscal Year: 2013
    ..Insights from the studies, including once unsuspected roles for lymphatic vessels, mast cells, lymphocytes and dendritic cells, suggest new paradigms for understanding evolution of ..
  45. Therapy for Secondary Lymphedema in Breast Cancer
    Annissa Furr; Fiscal Year: 2013
    ..to develop novel, slow-release delivery systems to treat lymphedema through regrowth of interrupted lymphatic vessels. This work will ultimately reduce post-treatment costs associated with breast cancer, and may be applied to ..
  46. Quantitative Analysis of Cancer Cell Motility using Microfluidic Devices
    Daniel Irimia; Fiscal Year: 2011
    ..the migration of the cancer cells in tissues is favored along preexisting paths in the form of blood or lymphatic vessels, collagen fibers, or white matter tracts...
  47. Engineering Functional Lymphatic Networks in Vitro
    JOE Y TIEN; Fiscal Year: 2010
    ..This work will study how to build lymphatic vessels - the vessels that drain organs of their excess fluids...
  48. Inhibition of VEGF receptor dimerization and signaling in corneal lymphangiogenes
    Jin Hong Chang; Fiscal Year: 2012
    ..Under normal physiological conditions, the cornea is alymphatic and surrounded by lymphatic vessels residing in the conjunctiva while corneal lymphangiogenic privilege is maintained...
  49. Impact of alcohol intoxication on lymphatic contractile mechanisms
    FLAVIA MOREIRA SOUZA; Fiscal Year: 2013
    ..Our preliminary data indicate that alcohol modulates phasic contractions of lymphatic vessels by decreasing the frequency yet increasing the magnitude of cyclic mobilizations of Ca2+ from internal ..
  50. Genetic investigation of Notch signaling in lymphatic endothelium
    Mark L Kahn; Fiscal Year: 2010
    ..presently no genetic means of investigating the function of this or other signaling pathways specifically in lymphatic vessels. The goal of this proposal is open genetic investigation of lymphangiogenesis by engineering transgenic mice ..
  51. A Nuclear Receptor COUP-TFII in Vascular Function: Angiogenesis and Tumoirgenesis
    Sophia Y Tsai; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Blood and lymphatic vessels constitute major circulatory networks, and dysfunctions in these networks often result in diseases and ..
  52. Impact of the Vascular System and CGM
    Don Kreutzer; Fiscal Year: 2013
    ..Currently there is no previous data or even conjecture in the literature on the role of lymphatic vessels (LV) or the combinations of BV &LV in enhancing sensor function in vivo...
  53. Causes and Consequences of Digestive Tract Lymphangiectasia
    Kathleen M Caron; Fiscal Year: 2013
    ..However, considering the essential role of lymphatic vessels in intestinal lipid absorption and the increased prevalence of inflammatory diseases of the intestine, it is ..
  54. 4D Microfluidic Platforms for Targeting Breast Cancer:Lymphatic Interactions
    Bonnie F Sloane; Fiscal Year: 2013
    ..microvascular endothelial cells can be used to identify druggable pathways associated with invasion into lymphatic vessels and lymphangiogenesis...
  55. Ocular Lymphangiogenesis
    DANIEL J CARR; Fiscal Year: 2010
    ..HSV-1-mediated lymphangiogenesis occurs thru VEGF-A expression by HSV-1-infected epithelial cells and the lymphatic vessels created are functional and contribute to the generation of the adaptive immune response to HSV- 1...
  56. Lymphatic Radiobiology
    Timothy P Padera; Fiscal Year: 2013
    ..While information on the radiosensitivity of many tissues Is available, the effects of radiation on lymphatic vessels have been largely unreported...
  57. Overcoming Drug Resistance to Nucleoside Analogs by Tumor-Targeted Active Nanofor
    Serguei V Vinogradov; Fiscal Year: 2013
    ..surface with multiple selected peptides having high affinity to overexpressed tumor EGF receptors or tumor lymphatic vessels. Nanogels degrade in tissues with the formation of non-toxic polymer conjugates...
  58. Mechanisms of VEGF-A regulated tumor lymphangiogenesis
    Sophia Ran; Fiscal Year: 2007
    ..The prerequisite for this process is generation of new lymphatic vessels accessible to tumor cells. The formation of new lymphatic vessels, i.e...
  59. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..Preliminary data indicates that Foxc2+/- mice have highly abnormal lymphatic vessels and lymph nodes analogous to those in patient's with LD...
  60. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..The goal of Aim #1 is to define the abnormalities of lymphatic vessels in chronic airway inflammation, identify the driving factors, and determine the consequences and ..
  61. Control of lymphatic vessel growth and development by platelets
    Mark L Kahn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Separation of blood and lymphatic vessels requires the hematopoietic signaling proteins SYK and SLP-76, but how blood cells perform this function is not known...
  62. Bone Morphogenic Protein Signaling in Lymphatic Endothelial Cells
    Suk Won Jin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lymphatic vessels are essential to maintain homeostasis of individuals...
  63. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The high pressure pushes fluid out of the capillaries faster that the lymphatic vessels can drain the fluid from the lungs...
  64. Endoscopic Detection of Fluorescein for Sentinel Lymph Node Biopsy
    James McGreevy; Fiscal Year: 2007
    ..The fluorescence endoscopy instrumentation will be used to define the lymphatic vessels and to find the sentinel lymph node with minimally-invasive surgical techniques...
  65. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  66. Physiological Basis of Vascular Contractility
    David Zawieja; Fiscal Year: 2006
    Hydrodynamic forces are important intrinsic regulators of contractile function for arterial, venous and lymphatic vessels. All 3 vessel types react to changes in transmural pressure and luminal shear stress, but their responses differ ..
  67. Short-term mesenteric lymphatic adaptation to trauma-related intestinal edema
    Emily Wilson; Fiscal Year: 2010
    ..When interstitial pressure exceeds central venous pressure, lymphatic vessels can act as conduit vessels, passively transporting lymph down a pressure gradient...
  68. MECHANISMS INVOLVED IN LYMPHATIC CONTRACTILE ACTIVITY
    David Zawieja; Fiscal Year: 2000
    ..Evaluation of membrane potential within the cells of the lymphatic vessels will be performed using the potentiometric fluorescent dye Di-8-ANEPPS...
  69. DISTRIBUTION OF LYMPHATICS IN THE DENTAL PULP
    Mark Bishop; Fiscal Year: 1990
    The existence of lymphatic vessels in the dental pulp has been surrounded by controversy. In the first study to use perfusion fixed specimens we have recently shown in cats that pulp lymphatic vessels are always present...
  70. Mechanisms That Mediate The Absence of Lymphatics in the Retina
    PATRICIA D AMORE; Fiscal Year: 2009
    ..All vascularized tissues, except the central nervous system (CNS), are invested with lymphatic vessels. Although significant progress has recently been made in understanding the molecules that regulate ..
  71. US with Submicron Bubbles for Sentinel Node Detection
    Erik Wisner; Fiscal Year: 2004
    ..Advantages are that nodes and associated afferent lymphatic vessels can be visualized directly and noninvasively in real-time, logistical and radiation safety issues associated ..
  72. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..endothelial cells now provides an entirely new dimension to identifying and understanding lymphatic flow and lymphatic vessels in cancer metastasis...