lymphatic vessels

Summary

Summary: Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.

Top Publications

  1. ncbi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
  2. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
  3. ncbi Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei-Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004
  4. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
  5. ncbi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
  6. ncbi Lymphatic vascular morphogenesis in development, physiology, and disease
    Stefan Schulte-Merker
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
    J Cell Biol 193:607-18. 2011
  7. ncbi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
  8. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young-Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
  9. ncbi Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
    Holger Pflicke
    Max Planck Institute of Biochemistry, Hofschneider Group Leukocyte Migration, 82152 Martinsried, Germany
    J Exp Med 206:2925-35. 2009
  10. ncbi Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
    Benjamin M Hogan
    Hubrecht Institute KNAW and University Medical Centre, Utrecht, The Netherlands
    Nat Genet 41:396-8. 2009

Research Grants

  1. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2010
  2. Angiopoietins in airway vascular leak and angiogenesis
    Donald M McDonald; Fiscal Year: 2010
  3. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
  4. Corneal Lymphatics & Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2011
  5. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2010
  6. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
  7. Mechanisms of VEGF-A regulated tumor lymphangiogenesis
    Sophia Ran; Fiscal Year: 2007
  8. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2005
  9. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
  10. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2010

Detail Information

Publications209 found, 100 shown here

  1. ncbi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
    The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a ..
  2. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    b>Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema...
  3. ncbi Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
    Hsei-Wei Wang
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Cruciform Building, Gower Street, University College London, London WC1E 6BT, UK
    Nat Genet 36:687-93. 2004
    ....
  4. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
    ....
  5. ncbi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  6. ncbi Lymphatic vascular morphogenesis in development, physiology, and disease
    Stefan Schulte-Merker
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
    J Cell Biol 193:607-18. 2011
    ..Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation...
  7. ncbi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..the origins of the lymphatic system in the embryo, and the mechanisms that direct growth of the network of lymphatic vessels, remain unclear...
  8. ncbi Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
    Young-Kwon Hong
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Genet 36:683-5. 2004
    ....
  9. ncbi Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
    Holger Pflicke
    Max Planck Institute of Biochemistry, Hofschneider Group Leukocyte Migration, 82152 Martinsried, Germany
    J Exp Med 206:2925-35. 2009
    ..rates, leukocyte extravasation from the blood circulation is well investigated, whereas intravasation into lymphatic vessels has hardly been studied...
  10. ncbi Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
    Benjamin M Hogan
    Hubrecht Institute KNAW and University Medical Centre, Utrecht, The Netherlands
    Nat Genet 41:396-8. 2009
    b>Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of ..
  11. ncbi Molecular regulation of angiogenesis and lymphangiogenesis
    Ralf H Adams
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 8:464-78. 2007
    Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates...
  12. ncbi Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
    Li Chen
    Program of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 189:417-24. 2010
    ..we show that Tbx1 is not required for lymphatic EC differentiation; rather, it is required for the growth and maintenance of lymphatic vessels. Our findings reveal a novel pathway for the development of the lymphatic vessel network.
  13. ncbi Combined blockade of VEGFR-2 and VEGFR-3 inhibits inflammatory lymphangiogenesis in early and middle stages
    Don Yuen
    Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 52:2593-7. 2011
    ..The purpose of this study was to investigate whether there is a time window for therapeutic intervention of corneal LG and whether a combined blockade of VEGFR-2 and VEGFR-3 effectively suppresses early-, middle-, or late-stage LG...
  14. ncbi Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity
    Evisa Gjini
    Hubrecht Institute KNAW and University Medical Centre, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Dis Model Mech 4:57-66. 2011
    ..Our study introduces an additional vertebrate model to study in vivo the function of Tie-2 in development and disease...
  15. ncbi Synchrony of high endothelial venules and lymphatic vessels revealed by immunization
    Shan Liao
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:3369-79. 2006
    ....
  16. ncbi Induction of lymphatic endothelial cell differentiation in embryoid bodies
    Ruediger Liersch
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Blood 107:1214-6. 2006
    ..Our results reveal, for the first time, that ES cells can differentiate into lymphatic endothelial cells, and they identify the EB assay as a powerful new tool to dissect the molecular mechanisms that control lymphatic vessel formation...
  17. ncbi Role of synectin in lymphatic development in zebrafish and frogs
    Karlien Hermans
    Vesalius Research Center, Vlaams Iustituut voor Biotechnologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Blood 116:3356-66. 2010
    ..These findings reveal a novel role for synectin in lymphatic development...
  18. ncbi Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development
    Fei Zhou
    Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China
    Am J Pathol 177:2124-33. 2010
    ..There was an uncharacteristic enlargement of collecting lymphatic vessels, and further analysis showed that smooth muscle cell coverage of collecting lymphatic vessels became much ..
  19. ncbi Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
    Eleni Bazigou
    Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 17:175-86. 2009
    ..Our findings reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects...
  20. ncbi Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome
    Susan L Dagenais
    Department of Human Genetics, University of Michigan, 4909 Buhl, Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Gene Expr Patterns 4:611-9. 2004
    ....
  21. ncbi FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
    Camilla Norrmen
    Molecular Cancer Biology Program, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Cell Biol 185:439-57. 2009
    ..of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process...
  22. ncbi Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 184:535-9. 2010
    The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation...
  23. ncbi Molecular control of lymphatic metastasis
    Marc G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Ann N Y Acad Sci 1131:225-34. 2008
    ..Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis...
  24. ncbi An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
    Louise A Johnson
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, and Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham Medical School, UK
    J Exp Med 203:2763-77. 2006
    ..How such an exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels are unknown...
  25. ncbi Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia
    Rainer Kunstfeld
    Cutaneous Biology Research Center, Massachusetts General Hospital, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Blood 104:1048-57. 2004
    ..They also indicate that inhibition of VEGF-A bioactivity might be a new approach to anti-inflammatory therapy...
  26. ncbi The lymphatic system in health and disease
    Leah N Cueni
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Lymphat Res Biol 6:109-22. 2008
    ..The discovery of various molecular markers allowing the distinction of blood and lymphatic vessels, together with the availability of a increasing number of in vitro and in vivo models to study various ..
  27. ncbi Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution
    Raghu P Kataru
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Guseong Dong, Daejeon, Korea
    Blood 113:5650-9. 2009
    Using a bacterial pathogen-induced acute inflammation model in the skin, we defined the roles of local lymphatic vessels and draining lymph nodes (DLNs) in antigen clearance and inflammation resolution...
  28. ncbi Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade
    Tina Dietrich
    Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, Erlangen, Germany
    Am J Pathol 171:361-72. 2007
    ..In contrast, the role of integrins in lymphangiogenesis, ie, the outgrowth of new from pre-existing lymphatic vessels, has so far been unclear...
  29. ncbi Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro
    Benjamin Vigl
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    Exp Cell Res 315:336-47. 2009
    b>Lymphatic vessels play an important role in tissue fluid homeostasis, intestinal fat absorption and immunosurveillance. Furthermore, they are involved in pathologic conditions, such as tumor cell metastasis and chronic inflammation...
  30. ncbi Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation
    Claus Cursiefen
    Department of Ophthalmology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cornea 25:443-7. 2006
    ..To study the time course of angiogenesis and lymphangiogenesis in the cornea after a short inflammatory insult. This might be helpful for the timing of corneal transplantation in high-risk eyes...
  31. ncbi The lymphatic vasculature: recent progress and paradigms
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Annu Rev Cell Dev Biol 21:457-83. 2005
    ..This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis...
  32. ncbi Lymphatic vessel density as prognostic marker in esophageal adenocarcinoma
    Reda S Saad
    Department of Pathology, Allegheny General Hospital
    Am J Clin Pathol 131:92-8. 2009
    ..Our study showed that angiogenesis and lymphangiogenesis have important roles in the progression of esophageal adenocarcinoma...
  33. ncbi Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos
    Masanori Hirashima
    The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dev Biol 316:149-59. 2008
    ..into the embryonic forelimb showed defective lymphatic drainage function and obstruction in collecting lymphatic vessels of Aspp1(-/-) embryos...
  34. ncbi Tumor lymphatics
    Jonathan Sleeman
    University of Heidelberg, Medical Faculty Mannheim, Ludolf Krehl Str 13 17, D 68167 Mannheim, Germany
    Semin Cancer Biol 19:285-97. 2009
    In this article we survey more than three centuries of observation and research into tumor-associated lymphatic vessels, and their role in the metastatic spread of cancer...
  35. ncbi Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration
    Hwee Ying Lim
    Department of Microbiology, Immunology Programme, Yoon Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore
    Am J Pathol 175:1328-37. 2009
    b>Lymphatic vessels are essential for lipid absorption and transport...
  36. ncbi Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development
    Pipsa Saharinen
    Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki FIN 00014, Finland
    Genes Dev 24:875-80. 2010
    ..Targeted disruption of Clp24 in mice led to enlarged lymphatic vessels having an abnormal smooth muscle cell coating...
  37. ncbi Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells
    Wei Zhuo
    National Engineering Laboratory for Anti Tumour Protein Therapeutics, Tsinghua University, Beijing, China
    J Pathol 222:249-60. 2010
    ....
  38. ncbi Role of lymphatic vessels in tumor immunity: passive conduits or active participants?
    Amanda W Lund
    Institute of Bioengineering and Swiss Institute of Experimental Cancer Research, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Mammary Gland Biol Neoplasia 15:341-52. 2010
    ..This review presents emerging evidence that lymphatic vessels are active modulators of immunity, perhaps fine-tuning the response to adjust the balance between peripheral ..
  39. ncbi Current views on the function of the lymphatic vasculature in health and disease
    Yingdi Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 24:2115-26. 2010
    ..In this review, we summarize the functional roles of the lymphatic vasculature in health and disease...
  40. ncbi Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell
    Guillermo Oliver
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Development 137:363-72. 2010
    ....
  41. ncbi Differential distribution of blood and lymphatic vessels in the murine cornea
    Tatiana Ecoiffier
    Center for Eye Disease and Development, School of Optometry, University of California, Berkeley, CA 94720, USA
    Invest Ophthalmol Vis Sci 51:2436-40. 2010
    ..The purpose of this study was to investigate this question and to examine whether and how the distribution patterns change during corneal inflammatory lymphangiogenesis (LG) and hemangiogenesis (HG)...
  42. ncbi A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: development, characterization, and applications
    Carmen Bonvin
    Institute of Bioengineering, School of Life Sciences LMBM Station 15, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Biotechnol Bioeng 105:982-91. 2010
    ..Therefore, this device is useful for studies of capillary morphogenesis, cell migration, contractile cells like fibroblasts, and multicellular cultures, all under interstitial flow...
  43. ncbi Regulation of lymphatic-blood vessel separation by endothelial Rac1
    Gabriela D'Amico
    Adhesion and Angiogenesis Laboratory, Institute of Cancer and Cancer Research UK, Bart s and the London Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK
    Development 136:4043-53. 2009
    ..Our studies identify Rac1 as a crucial part of the migratory machinery required for endothelial cells to separate and form lymphatic vasculature...
  44. ncbi The location of lymphangiogenesis is an independent prognostic factor in rectal cancers with or without preoperative radiotherapy
    A Holmqvist
    Department of Medical Oncology, Institute of Clinical and Experimental Medicine, Linkoping University, Sweden
    Ann Oncol 21:512-7. 2010
    ....
  45. ncbi Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up
    Rabab A A Mohammed
    Department of Clinical Oncology, University of Nottingham, UK
    J Pathol 223:358-65. 2011
    ..VI status should be included routinely in breast cancer staging systems...
  46. ncbi Cellular-level characterization of lymph vessels in live, unlabeled corneas by in vivo confocal microscopy
    Beatrice Bourghardt Peebo
    Department of Ophthalmology, Linkoping University Hospital, Linkoping, Sweden
    Invest Ophthalmol Vis Sci 51:830-5. 2010
    ..To determine whether in vivo confocal microscopy (IVCM) of the cornea can be used for the label-free detection and monitoring of lymph vessels in live corneas...
  47. ncbi Lymphatic development
    Matthew G Butler
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 87:222-31. 2009
    ..This review focuses on the mechanisms regulating development of the lymphatic vasculature during embryogenesis...
  48. ncbi Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 19:392-8. 2006
    ..b>Lymphatic vessels were detected by immunohistochemical stain using an antibody specific for the lymphatic endothelial cells (..
  49. ncbi Genes tell lymphatics to sprout or not
    Judah Folkman
    Nat Immunol 5:11-2. 2004
  50. ncbi Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Pathol 177:3202-14. 2010
    ..The use of these strategies may represent a novel means of preventing lymphedema after lymph node resection...
  51. ncbi Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis
    Laura Carramolino
    Departamento de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain
    Circ Res 106:1197-201. 2010
    ..However, the basis for these defects has remained unknown because the mutations characterized affect more than one blood lineage...
  52. ncbi Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice
    Jianxin Fu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Clin Invest 118:3725-37. 2008
    ..EHC T-syn(-/-) mice exhibited embryonic and neonatal lethality associated with disorganized and blood-filled lymphatic vessels. Bone marrow transplantation and EC C1galt1 transgene rescue demonstrated that lymphangiogenesis ..
  53. ncbi Emilin1 deficiency causes structural and functional defects of lymphatic vasculature
    Carla Danussi
    Division of Experimental Oncology 2, Department of Molecular Oncology and Translational Research, CRO IRCCS, Aviano, Pordenone, Italy
    Mol Cell Biol 28:4026-39. 2008
    ..an elastic microfibril-associated protein, is highly expressed by LECs in vitro and colocalizes with lymphatic vessels in several mouse tissues...
  54. ncbi Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer
    Bong Hyun Jeon
    National Research Laboratory of Vascular Biology and Biomedical Research Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Cancer Res 68:1100-9. 2008
    ..Here, we identified and characterized peritoneal lymphatic vessels in OVCA mice, a model generated by implantation of human OVCA cells into athymic nude mice...
  55. ncbi Role of lymphangiogenic factors in tumor metastasis
    Yulong He
    Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, POB 63 (Haartmaninkatu 8, 00014 Helsinki, Finland
    Biochim Biophys Acta 1654:3-12. 2004
    Nearly four centuries after the discovery of lymphatic vessels, the molecular mechanisms underlying their development are beginning to be elucidated...
  56. ncbi Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo
    Claudius Conrad
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 119:281-9. 2009
    ..We evaluated the potential of human and murine mesenchymal stem cells (MSCs) to acquire a lymphatic phenotype in vitro and to enhance lymphatic regeneration in vivo...
  57. ncbi Developmental and pathological lymphangiogenesis: from models to human disease
    Hélène Maby-El Hajjami
    Division of Experimental Oncology, Centre Pluridisciplinaire d Oncologie, CHUV and University of Lausanne, Epalinges, Switzerland
    Histochem Cell Biol 130:1063-78. 2008
    ..approaches have been instrumental in understanding the major steps controlling growth and remodeling of lymphatic vessels. This review highlights the recent insights and developments in the field of lymphatic vascular biology.
  58. ncbi Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3
    Yunling Xu
    Institut National de la Sante et de la Recherche Medicale, Unité 833, 75005 Paris, France
    J Cell Biol 188:115-30. 2010
    ..Thus, interaction between Nrp2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C...
  59. ncbi Lymphangiogenesis: in vitro and in vivo models
    Françoise Bruyére
    Laboratory of Tumor and Developmental Biology, GIGA Cancer, University of Liege, Tour de Pathologie, CHU B23 Sart Tilman, Ave de l Hôpital 3, Liege, Belgium
    FASEB J 24:8-21. 2010
    Lymphangiogenesis, the formation of new lymphatic vessels from preexisting ones, is an important biological process associated with diverse pathologies, such as metastatic dissemination and graft rejection...
  60. ncbi Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory, Haartman Institute and Ludwig Institute for Cancer Research, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Nat Med 13:1458-66. 2007
    ..Here we show, using a newly established mouse model, that collecting lymphatic vessels can be regenerated and fused to lymph node transplants after lymph node removal...
  61. ncbi Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design
    Melody A Swartz
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Semin Immunol 20:147-56. 2008
    ....
  62. ncbi D2-40 expression by breast myoepithelium: potential pitfalls in distinguishing intralymphatic carcinoma from in situ carcinoma
    Joseph T Rabban
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Pathol 39:175-83. 2008
    ..We recommend that myoepithelial markers be used in conjunction with D2-40 to distinguish solid intralymphatic tumor emboli from solid pattern in situ carcinoma...
  63. ncbi Lymphatic vessel density, microvessel density and lymphangiogenic growth factor expression in colorectal cancer
    S E Duff
    Department of Surgery, Christie Hospital NHS Trust, Manchester, UK
    Colorectal Dis 9:793-800. 2007
    ..The aim of this study was to quantify LVD and MVD in colorectal cancer, determine the relationship between LVD, MVD and clinicopathological variables and examine the relationship between LVD and tumour expression of VEGF-C and VEGF-D...
  64. ncbi Lymphangiogenesis in development and human disease
    Kari Alitalo
    Molecular Cancer Biology Laboratory, Ludwig Institute for Cancer, Research, P O B 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Nature 438:946-53. 2005
    ..b>Lymphatic vessels are also an essential part of the body's immune defence...
  65. ncbi Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
    Natasha L Harvey
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Nat Genet 37:1072-81. 2005
    ..allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
  66. ncbi TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair
    Nicholas W Clavin
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Physiol Heart Circ Physiol 295:H2113-27. 2008
    ..These findings imply that the clinical interventions that diminish TGF-beta1 expression may be useful in promoting more rapid lymphatic regeneration...
  67. ncbi Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha
    Carla Mouta-Bellum
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA
    Dev Dyn 238:2670-9. 2009
    ..Our data suggest that Pik3r1 isoforms are required for distinct steps of embryonic lymphangiogenesis in different organ microenvironments, whereas they are largely dispensable for hemangiogenesis...
  68. ncbi Intratumoural lymphatics in benign and malignant soft tissue tumours
    G Mahendra
    Department of Pathology, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK
    Virchows Arch 453:457-64. 2008
    Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known...
  69. ncbi Clinical and experimental research of corneal lymphangiogenesis after keratoplasty
    Shiqi Ling
    Department of Ophthalmology, Guangzhou Children s Hospital, Guangzhou, PR China
    Ophthalmologica 222:308-16. 2008
    ..Blood and lymphatic vessels in human transplanted corneas were identified by LYVE-1 and CD(31) immunohistochemistry, then the ..
  70. ncbi Impact of lymphatic vessels on the heart
    Y Cui
    Case Cardiovascular Research Institute and Harrington McLaughlin Heart and Vascular Institute, Case Western Reserve University, Cleveland, OH 44106, USA
    Thorac Cardiovasc Surg 58:1-7. 2010
    This review updates the knowledge in the research field of cardiac lymphatic vessels by collecting both scientific evidence and hypotheses, including cardiac lymphatic vessel anatomy and lymph flow, the mechanism of cardiac lymphatic ..
  71. ncbi The role of the lymphatic circulation in the natural history and expression of cardiovascular disease
    Kenta Nakamura
    Chief of Consultative Cardiology, Director, Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Int J Cardiol 129:309-17. 2008
    ..Intensive exploration of lymphatic mechanisms of cardiovascular disease is likely to lead to enhanced insights and novel therapeutic approaches...
  72. ncbi Contractile activity of lymphatic vessels is altered in the TNBS model of guinea pig ileitis
    Theresa F Wu
    Dept. of Physiology and Biophysics, Univ. of Calgary, 3330 Hospital Drive N.W, Calgary, Alberta, Canada, USA
    Am J Physiol Gastrointest Liver Physiol 291:G566-74. 2006
    ..The present results demonstrate that lymphatic contractile function is altered in TNBS-induced ileitis and suggest a role for prostanoids in the lymphatic dysfunction...
  73. ncbi CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia
    Sonia Berrih-Aknin
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, Institut Paris Sud Cytokines, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Ann Neurol 66:521-31. 2009
    ..Our thymic transcriptome study demonstrated increased expression of CCL21, a recruiter of immune cells. Accordingly, we are investigating its implication in MG pathogenesis...
  74. ncbi Lymphatic vessels assessment in feline mammary tumours
    Giuseppe Sarli
    Department of Veterinary Public Health and Animal Pathology, Bologna, Italy
    BMC Cancer 7:7. 2007
    The lymphatic vessels play a crucial role in a variety of human cancers since tumour cell lymphatic invasion significantly influences prognosis...
  75. ncbi Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds
    Anne Saaristo
    Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    FASEB J 18:1707-9. 2004
    ..Our results show that VEGF-C gene expression results in the formation of anastomoses between the lymphatic vessels of the skin flap and the surrounding lymphatic vasculature...
  76. ncbi Spontaneous lymphatic vessel formation and regression in the murine cornea
    Hui Zhang
    Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California 94720, USA
    Invest Ophthalmol Vis Sci 52:334-8. 2011
    ..The differential behaviors between the lymphatic and blood vessels under normal development and inflammation conditions are also compared...
  77. ncbi Prediction of lymphatic invasion by peritumoral lymphatic vessel density in prostate biopsy cores
    Kenji Kuroda
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Prostate 68:1057-63. 2008
    ..This study was designed to examine whether lymphangiogenesis in prostate biopsy could predict lymphatic spread in radical prostatectomy specimens...
  78. ncbi Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans
    Audrey C Au
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 87:436-44. 2010
    ..These results suggest a unique and conserved role for PTPN14 in the regulation of lymphatic development in mammals and a nonconserved role in choanal development in humans...
  79. ncbi Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer
    Y Nakamura
    Department of Pathology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama, 641 8509, Japan
    J Clin Pathol 59:77-82. 2006
    Metastasis to regional lymph nodes (LNs) through lymphatic vessels is common in cancer progression and is an important prognostic factor in many cancers. Recent evidence suggests that tumour lymphangiogenesis promotes lymphatic metastasis.
  80. ncbi Different significance between intratumoral and peritumoral lymphatic vessel density in gastric cancer: a retrospective study of 123 cases
    Xiao lei Wang
    Department of Gastroenternology, Institute of Digestive Disease, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, PR China
    BMC Cancer 10:299. 2010
    ..The purpose of current study is to investigate the significant difference between intratumoral and peritumoral lymphatic vessel density (LVD) in gastric cancer and their correlations with lymphangiogenetic growth factors...
  81. ncbi Free muscle flap transfer as a lymphatic bridge for upper extremity lymphedema
    Dale A Classen
    Department of Surgery, Division of Plastic Surgery, University of Saskatchewan and Royal University Hospital, Saskatoon, Saskatchewan, Canada
    J Reconstr Microsurg 21:93-9. 2005
    ..Lymphatic drainage is demonstrated across the free flap by lymphoscintigraphy postoperatively. This is the first case report using a free muscle flap to reestablish lymphatic flow across an area of obstructive limb lymphedema...
  82. ncbi Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation
    Emma J Gordon
    Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, 5000, Australia
    Development 137:3899-910. 2010
    ..via the ability to transdifferentiate into lymphatic endothelial cells and be incorporated into growing lymphatic vessels; and (2) providing a crucial source of pro-lymphangiogenic growth factors and proteases...
  83. ncbi Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse
    Inho Choi
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 117:362-5. 2011
    ..other Prox1-expressing organs, and enabled us to conveniently visualize detailed structure and morphology of lymphatic vessels and networks throughout development...
  84. ncbi Imaging of lymphatic vessels in breast cancer-related lymphedema: intradermal versus subcutaneous injection of 99mTc-immunoglobulin
    Chandra K Solanki
    Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge, UK
    AJR Am J Roentgenol 186:1349-55. 2006
    ..RESULTS: Imaging after intradermal injection clearly showed discrete lymphatic vessels in five of six patients, in contrast to imaging after subcutaneous injection, which did not show any ..
  85. ncbi Novel expression and characterization of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1) by conjunctival cells
    Lu Chen
    Laboratory of Immunology, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 46:4536-40. 2005
    ..RESULTS: The data demonstrate, for the first time, that in addition to its expression on lymphatic vessels, LYVE-1 was expressed on CD45+, CD11b+, and CD31- conjunctival cells, indicating a bone-marrow-derived ..
  86. ncbi Lymphangiogenesis in myocardial remodelling after infarction
    Y Ishikawa
    Department of Pathology, Toho University School of Medicine, Tokyo, Japan
    Histopathology 51:345-53. 2007
    ..The aim was to investigate by D2-40 immunohistochemistry the sequential changes in lymphatic distribution in the process of myocardial remodelling after myocardial infarction (MI)...
  87. ncbi Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation
    Javier Mora
    Departamento de Parasitologia, Universidad de Costa Rica, San Jose, Costa Rica
    PLoS Negl Trop Dis 2:e318. 2008
    ..Since lymph flow plays a role in the maintenance of tissue fluid balance, the effect of B. asper venom on collecting lymphatic vessels was studied.
  88. ncbi Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
    Meit A Björndahl
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Cancer Res 65:9261-8. 2005
    ..in vivo and that overexpression of VEGF-A in murine T241 fibrosarcomas induced the growth of peritumoral lymphatic vessels, which occasionally penetrated into the tumor tissue...
  89. ncbi [Molecular mechanisms of lymphatic development]
    Hajime Kubo
    Molecular and Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan
    Seikagaku 76:1210-6. 2004
  90. ncbi [Advances in lymphangiogenesis and metastasis of tumor]
    Xiao-Chu Yan
    Zhonghua Bing Li Xue Za Zhi 34:370-2. 2005
  91. ncbi [Tumor lymphangiogenesis in cervical squamous cell carcinoma and its clinical significance]
    Jian-Ping Zhang
    Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
    Zhonghua Yi Xue Za Zhi 85:1551-4. 2005
    ..Computer-assisted morphometric analysis was used to quantitatively analyze the lymphatic vessels in intratumor and peritumor areas. The association with clinicopathologic data was analyzed...
  92. ncbi VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
    Andrew V Benest
    Microvascular Research Laboratories, Department of Physiology, University of Bristol, BS2 8EJ Bristol, UK
    Cardiovasc Res 78:315-23. 2008
    ....
  93. ncbi Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer
    Yi Tao Jia
    Department of Oncology, the People s Hospital of Hebei Province, Shijiazhuang 050051, Hebei Province, China
    World J Gastroenterol 10:3261-3. 2004
    ..To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and the relationship between VEGF-C and lymphangiogenesis, lymph node metastasis in colorectal cancer...
  94. ncbi Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis
    Toshio Kumasaka
    Department of Pathology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 13 8421, Japan
    Am J Surg Pathol 28:1007-16. 2004
    ..Our study is likely to provide a novel point of view on the pathophysiologic significance of lymphangiogenesis in LAM...
  95. ncbi Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation
    Pipsa Saharinen
    Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, P.O.B. 63 (Haartmaninkatu 8, 00014 Helsinki, Finland
    Trends Immunol 25:387-95. 2004
  96. ncbi Tumor-derived lymphangiogenic factors and lymphatic metastasis
    Yihai Cao
    Laboratory of Angiogenesis Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Biomed Pharmacother 61:534-9. 2007
    ..Lymphangiogenesis, a complex process of sprouting of new lymphatic vessels, is regulated by multiple direct and indirect growth factors...
  97. ncbi Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Cancer 101:973-8. 2004
    ..In the current study, the authors investigated whether tumor lymphangiogenesis may be related to the risk of lymph node metastasis and to clinical outcome in patients with HNSCC...
  98. ncbi Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis
    Ivana Crnic
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland
    Cancer Res 64:8630-8. 2004
    ..These results also establish Rip1Tag2;NCAM-deficient mice as a unique model for stochastic, endogenous tumor lymphangiogenesis and lymph node metastasis in immunocompetent mice...
  99. ncbi Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
    ..Our primary hypotheses were that using immunohistochemical markers of lymphatic vessels and of tumor cells would improve detection of lymphatic invasion and that lymphatic invasion would correlate ..
  100. ncbi High lymphatic vessel density correlates with overexpression of VEGF-C in gastric cancer
    Takashi Hachisuka
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara 634 8522, Japan
    Oncol Rep 13:733-7. 2005
    ..Furthermore, high LVD exhibited a significant correlation with VEGF-C expression. Our findings suggest that VEGF-C plays a pivotal role for lymphangiogenesis and tumor growth in gastric cancer...
  101. ncbi Molecular lymphangiogenesis: new players
    Tuomas Tammela
    Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Helsinki University Central Hospital, POB 63 (Haartmaninkatu 8, 00014 University of Helsinki, Helsinki, Finland
    Trends Cell Biol 15:434-41. 2005
    ..has been known for over a century, but the molecular players involved in lymphangiogenesis--the formation of lymphatic vessels--have remained unknown until recently...

Research Grants85

  1. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2010
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  2. Angiopoietins in airway vascular leak and angiogenesis
    Donald M McDonald; Fiscal Year: 2010
    This project will examine the diverse actions of angiopoietins on airway blood vessels and lymphatic vessels with the goal of understanding underlying mechanisms of airway inflammation and developing new treatment strategies...
  3. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
    ..their clearance is thought to be emigration from the inflammatory focus to the draining lymph node through lymphatic vessels. This model for the fate of monocyte-derived cells during acute inflammation is, however, based on limited ..
  4. Corneal Lymphatics & Adaptive Immunity
    DANIEL J CARR; Fiscal Year: 2011
    ..More importantly, we have discovered the genesis of lymphatic vessels in the cornea proper in response to HSV-1 infection operates thru a unique pathway distinct from what has ..
  5. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2010
    Absence of blood and lymphatic vessels in the normal cornea is essential for optical clarity and optimal vision...
  6. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..Preliminary data indicates that Foxc2+/- mice have highly abnormal lymphatic vessels and lymph nodes analogous to those in patient's with LD...
  7. Mechanisms of VEGF-A regulated tumor lymphangiogenesis
    Sophia Ran; Fiscal Year: 2007
    ..The prerequisite for this process is generation of new lymphatic vessels accessible to tumor cells. The formation of new lymphatic vessels, i.e...
  8. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2005
    ..Preliminary data indicates that Foxc2+/- mice have highly abnormal lymphatic vessels and lymph nodes analogous to those in patient's with LD...
  9. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2010
    ..Thus, though it is rarely considered, lymphatic vessels are likely to be key participants in cholesterol homeostasis...
  10. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2010
    ..function of VEGF-C is distinctly different from its known paracrine function of inducing the growth of new lymphatic vessels. We believe that by protecting the prostate cancer cells from stress-induced apoptosis, VEGF-C promotes ..
  11. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..The goal of Aim #1 is to define the abnormalities of lymphatic vessels in chronic airway inflammation, identify the driving factors, and determine the consequences and ..
  12. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The high pressure pushes fluid out of the capillaries faster that the lymphatic vessels can drain the fluid from the lungs...
  13. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Robert Drake; Fiscal Year: 2001
    ..The high pressure pushes fluid out of the capillaries faster that the lymphatic vessels can drain the fluid from the lungs...
  14. TNF family members for lymph angiogenesis and lymph node hypertrophy
    Yang Xin Fu; Fiscal Year: 2010
    Rapid development of lymphatic vessels (LV) and high endothelial venules (HEV) in peripheral tissues leads to hypertrophy of draining lymph nodes (LN) during inflammation/vaccination, but the molecular mechanism regulating LN ..
  15. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas Vlahakis; Fiscal Year: 2007
    ..such as lymphedema are clearly associated with genetic abnormalities of the VEGF control system for the lymphatic vessels. By addressing the Specific Aims of this proposal the poorly understood and appreciated biology of pulmonary ..
  16. VPF/VEGF IN NORMAL AND NEOPLASTIC SKIN ANGIOGENESIS
    Michael Detmar; Fiscal Year: 2003
    ..b>Lymphatic vessels are the predominant path for the metastatic spread of skin cancers, and we found that VEGF-C, although ..
  17. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2007
    This project will examine the diverse actions of angiopoietins on airway blood vessels and lymphatic vessels with the goal of understanding underlying mechanisms of airway inflammation and developing new treatment strategies...
  18. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2009
    This project will examine the diverse actions of angiopoietins on airway blood vessels and lymphatic vessels with the goal of understanding underlying mechanisms of airway inflammation and developing new treatment strategies...
  19. Endoscopic Detection of Fluorescein for Sentinel Lymph Node Biopsy
    James McGreevy; Fiscal Year: 2007
    ..The fluorescence endoscopy instrumentation will be used to define the lymphatic vessels and to find the sentinel lymph node with minimally-invasive surgical techniques...
  20. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  21. Physiological Basis of Vascular Contractility
    David Zawieja; Fiscal Year: 2006
    Hydrodynamic forces are important intrinsic regulators of contractile function for arterial, venous and lymphatic vessels. All 3 vessel types react to changes in transmural pressure and luminal shear stress, but their responses differ ..
  22. Bronchial Vascular Proliferation and Function
    Elizabeth Wagner; Fiscal Year: 2011
    ..We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries...
  23. Short-term mesenteric lymphatic adaptation to trauma-related intestinal edema
    Emily Wilson; Fiscal Year: 2010
    ..When interstitial pressure exceeds central venous pressure, lymphatic vessels can act as conduit vessels, passively transporting lymph down a pressure gradient...
  24. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2010
    ..The model utilizes RFP-labeled human pancreatic cancer cells and monoclonal anti-LYVE1 antibody to label lymphatic vessels in order to image lymphatic trafficking of tumor cells...
  25. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2010
    ..The model utilizes RFP-labeled human pancreatic cancer cells and monoclonal anti-LYVE1 antibody to label lymphatic vessels in order to image lymphatic trafficking of tumor cells...
  26. The Lymphatic System in the Primate corpus Luteum
    Fuhua Xu; Fiscal Year: 2007
    ..1 - To investigate the presence, localization, and dynamics of lymphatic vessels in the primate ovary, specifically in the CL throughout the luteal lifespan of the menstrual cycle...
  27. VPF/VEGF IN NORMAL AND NEOPLASTIC SKIN ANGIOGENESIS
    Michael Detmar; Fiscal Year: 2007
    ..is to characterize the molecular mechanisms that regulate the generation and function of blood vessels and lymphatic vessels in the skin...
  28. Fox Transcription Factors in Vascular Development
    Tsutomu Kume; Fiscal Year: 2009
    ..mechanisms of congenital cardiovascular anomalies, including arteriovenous malformations and abnormal lymphatic vessels. The proposed studies will significantly contribute to a better understanding of the causes of congenital ..
  29. NF-kB mediated induction of VEGFR-3 and new lymphatic vessels in breast cancer
    Sophia Ran; Fiscal Year: 2010
    ..We propose to delineate the molecular events that associate tumor inflammation, the formation of new lymphatic vessels and lymphatic metastasis...
  30. Control of lymphatic vessel growth and development by platelets
    Mark L Kahn; Fiscal Year: 2010
    Separation of blood and lymphatic vessels requires the hematopoietic signaling proteins SYK and SLP-76, but how blood cells perform this function is not known...
  31. US with Submicron Bubbles for Sentinel Node Detection
    Erik Wisner; Fiscal Year: 2004
    ..Advantages are that nodes and associated afferent lymphatic vessels can be visualized directly and noninvasively in real-time, logistical and radiation safety issues associated ..
  32. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..endothelial cells now provides an entirely new dimension to identifying and understanding lymphatic flow and lymphatic vessels in cancer metastasis...
  33. Influences of Lymph Flow on the Lymphatic Pump
    David Zawieja; Fiscal Year: 2007
    ..of the amplitude and frequency of contractions induced by a controlled increase in imposed flow in isolated lymphatic vessels. Others have shown increases in the contraction frequency, reductions in lymphatic diameters and decreases ..