Genomes and Genes
Summary: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Publications236 found, 100 shown here
- Smad5 is dispensable for adult murine hematopoiesisSofie Singbrant
Lund University, BMC A12, 221 84 Lund, Sweden
Blood 108:3707-12. 2006..of induced animals revealed unperturbed cell numbers and lineage distribution in peripheral blood (PB), bone marrow (BM), and the spleen...
- CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cellsLinhua Jin
Department of Clinical Pathology, Juntendo University School of Medicine, Tokyo, Japan
Mol Cancer Ther 7:48-58. 2008..driven by constitutively activated Bcr-Abl tyrosine kinase, which causes the defective adhesion of CML cells to bone marrow stroma...
- SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsMark J Kiel
Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Cell 121:1109-21. 2005..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum...
- Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell nichesTatsuki Sugiyama
Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Immunity 25:977-88. 2006In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear...
- Adult rat and human bone marrow stromal cells differentiate into neuronsD Woodbury
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci Res 61:364-70. 2000b>Bone marrow stromal cells exhibit multiple traits of a stem cell population. They can be greatly expanded in vitro and induced to differentiate into multiple mesenchymal cell types...
- Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironmentBenedetto Sacchetti
Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
Cell 131:324-36. 2007The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive...
- Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1T Nagasawa
Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
Nature 382:635-8. 1996..and that although the numbers of B-cell progenitors in mutant embryos were severely reduced in fetal liver and bone marrow, myeloid progenitors were reduced only in the bone marrow but not in the fetal liver, indicating that PBSF/SDF-..
- CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrowKyle J Eash
Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Clin Invest 120:2423-31. 2010..Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal ..
- Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilizationMatthew J Christopher
Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Blood 114:1331-9. 2009..cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone ..
- Awakening dormant haematopoietic stem cellsAndreas Trumpp
Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
Nat Rev Immunol 10:201-9. 2010Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells...
- Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker padNarihito Nagoshi
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Cell Stem Cell 2:392-403. 2008..Here we identified NCSCs in the bone marrow (BM), dorsal root ganglia, and whisker pad and prospectively isolated them from adult transgenic mice encoding ..
- Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphateRajita Pappu
Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
Science 316:295-8. 2007..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
- Detection of functional haematopoietic stem cell niche using real-time imagingYucai Xie
Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
Nature 457:97-101. 2009..HSCs home to bone marrow through the vascular system...
- Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrowKaren Bieback
Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
Stem Cells 27:2331-41. 2009..Contradictory results with bone marrow (BM)-derived MSCs have initiated a comprehensive comparison of HS, tPRP, and pooled human platelet lysate (pHPL)..
- Detection of minimal residual disease in blood and bone marrow in early stage breast cancerSavitri Krishnamurthy
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 116:3330-7. 2010The significance of circulating tumor cells (CTCs) in blood and of disseminated tumor cells (DTCs) in bone marrow (BM) in patients with early stage breast cancer is unclear...
- Haematopoietic stem cell release is regulated by circadian oscillationsSimon Mendez-Ferrer
Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
Nature 452:442-7. 2008..HSCs and their progenitors fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment...
- Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAsFederica Collino
Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
PLoS ONE 5:e11803. 2010..MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling ..
- Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasiA B Reis
Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Departamento de Análises Clínicas Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil
Clin Exp Immunol 146:303-11. 2006..Herein, we have assessed the correlation between the clinical status as well as the impact of bone marrow parasite density on the phenotypic profile of peripheral blood leucocytes in 40 Brazilian dogs naturally ..
- Bone marrow microenvironment and the identification of new targets for myeloma therapyK Podar
Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics, Dana Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Boston, MA 02115, USA
Leukemia 23:10-24. 2009..both early and late genetic changes in the tumor cell as well as selective supportive conditions by the bone marrow (BM) microenvironment...
- Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targetsTeru Hideshima
Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Nat Rev Cancer 7:585-98. 2007..The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies...
- Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3I Vande Broek
Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Laarbeeklaan 101, Belgium
Br J Cancer 88:855-62. 2003The restricted bone marrow (BM) localisation of multiple myeloma (MM) cells most likely results from a specific homing influenced by chemotactic factors, combined with the proper signals for growth and survival provided by the BM ..
- Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesisScott T Avecilla
Department of Medicine, Division of Hematology-Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
Nat Med 10:64-71. 2004..Here we report that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production...
- Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool sizeSebastian Stier
Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Exp Med 201:1781-91. 2005..for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment...
- Live-animal tracking of individual haematopoietic stem/progenitor cells in their nicheCristina Lo Celso
Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Nature 457:92-6. 2009..confocal microscopy and two-photon video imaging of individual haematopoietic cells in the calvarium bone marrow of living mice over time, we examine the relationship of haematopoietic stem and progenitor cells to blood ..
- Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionF Kontgen
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Genes Dev 9:1965-77. 1995..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
- Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermisUna Riekstina
Faculty of Medicine, University of Latvia, Riga LV 1001, Latvia
Stem Cell Rev 5:378-86. 2009Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues, e.g., bone marrow, adipose tissue, dermis, hair follicles, heart, liver, spleen, dental pulp...
- The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistanceMark B Meads
Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Clin Cancer Res 14:2519-26. 2008The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells...
- Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)I Kotsianidis
Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
Leukemia 23:510-8. 2009..MDS), immune deregulation and autoimmunity in the early stages might lead to ineffective hematopoiesis and bone marrow (BM) failure, whereas late-stage disease is characterized by the immune escape of the malignant clone...
- Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression patternKatharina E Effenberger
Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Breast Cancer Res Treat 125:729-38. 2011..Using these antibodies bone marrow aspirates from 391 breast cancer patients (M(0), pT1-3, pN0-3) were screened for the presence of DTC...
- Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cellsAngela Colmone
Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA
Science 322:1861-5. 2008..imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments that sequester transplanted human CD34+ (HPC-enriched) cells...
- Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell functionBrahmananda R Chitteti
Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Blood 115:3239-48. 2010..These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs...
- Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injuryJie Ma
Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Acaademy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
Haematologica 92:889-96. 2007..senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchymal stem cells (MSC)...
- Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancerA Daskalaki
Department of Pathology, University General Hospital of Heraklion, Crete 71110, Greece
Br J Cancer 101:589-97. 2009..rates and evaluate the clinical relevance of cytokeratin-19 (CK-19) mRNA-positive cells in the peripheral blood (circulating tumour cells, CTCs) and bone marrow (disseminated tumour cells; DTCs) of patients with early breast cancer.
- The relationship between bone, hemopoietic stem cells, and vasculatureSarah L Ellis
Peter MacCallum Cancer Centre, Melbourne, Australia
Blood 118:1516-24. 2011....
- Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistanceNadine N Bewry
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33613, USA
Mol Cancer Ther 7:3169-75. 2008..The bone marrow is the predominant microenvironment of CML and is a rich source of both soluble factors and extracellular ..
- Microenvironmental niches in the bone marrow required for B-cell developmentTakashi Nagasawa
Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Nat Rev Immunol 6:107-16. 2006..This article summarizes the recent advances in research on the earliest B-cell precursors, their requisite environmental factors and the cellular niches that supply these factors and maintain B cells during their development...
- Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patientsKjersti Flatmark
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Clin Cancer Res 8:444-9. 2002Detection of micrometastatic cells in bone marrow (BM) may potentially be of prognostic value in colorectal cancer (CRC)...
- Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularizationSang Mo Kwon
Stem Cell Translational Research Laboratory, RIKEN Center For Developmental Biology Institute of Biomedical Research and Innovation, Kobe, Japan
Circulation 118:157-65. 2008..Despite accumulating evidence that proves the pivotal role of endothelial progenitor cells (EPCs) in ischemic neovascularization, the key signaling cascade that regulates functional EPC kinetics remains unclear...
- SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossificationTakako Hattori
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
Development 137:901-11. 2010..The transgenic offspring showed an almost complete lack of bone marrow in newborns, owing to strongly retarded vascular invasion into hypertrophic cartilage and impaired cartilage ..
- Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cellsTanja Fehm
Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
Breast Cancer Res 11:R59. 2009..of CTCs in blood, we evaluated the correlation between CTCs and disseminated tumor cells (DTCs) in the bone marrow (BM), and we characterized CTCs for the expression of HER2, the estrogen receptor (ER) and the progesterone ..
- Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligandBeate Heissig
Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
Cell 109:625-37. 2002Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals...
- The bone marrow vascular niche: home of HSC differentiation and mobilizationHans-Georg Kopp
Weill Medical College of Cornell University, New York, New York, USA
Physiology (Bethesda) 20:349-56. 2005The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells...
- G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrowCraig L Semerad
Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
Blood 106:3020-7. 2005..CXC motif, receptor 4), generates signals that regulate hematopoietic progenitor cell (HPC) trafficking in the bone marrow. During granulocyte colony-stimulating factor (G-CSF)-induced HPC mobilization, CXCL12 protein expression in ..
- Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarctionEwa K Zuba-Surma
Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
J Cell Mol Med 15:1319-28. 2011Adult bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) exhibit a Sca-1(+)/Lin(-)/CD45(-) phenotype and can differentiate into various cell types, including cardiomyocytes and endothelial cells...
- Nanobodies as tools for in vivo imaging of specific immune cell typesKurt De Groeve
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
J Nucl Med 51:782-9. 2010..In the present study, we have evaluated the use of Nanobodies as a generic method for imaging the in vivo biodistribution of specific immune cell types, using myeloid cells as an example...
- Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applicationsKarina T Wright
Spinal Studies and Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
Stem Cells 29:169-78. 2011Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies...
- MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathwayJ Li
State Key Laboratory of Oral Diseases, West China College of Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
Cell Prolif 43:333-43. 2010..study was carried out to reveal functions and mechanisms of MEK/ERK and p38 pathways in chondrogenesis of rat bone marrow mesenchymal stem cells (BMSCs), and to investigate further any interactions between the mitogen-activated ..
- The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move inArmin Ehninger
Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
J Exp Med 208:421-8. 2011..In mammals, the best understood niche is that harboring bone marrow hematopoietic stem cells (HSCs)...
- Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapseOsamu Imataki
Division of Hematology, Faculty of Medicine, Kagawa University, Kagawa, Japan
Int J Clin Oncol 15:112-5. 2010..Although her bone marrow achieved remission after induction therapy, there was a small residual population of leukemic cells in the ..
- On the adaptation of endosteal stem cell niche function in response to stressYi Jiang
University of Washington, Department of Medicine Hematology, Seattle, WA 98195, USA
Blood 114:3773-82. 2009..A similar phenotype was observed with cells rendered G(i)-protein signaling incompetent by pertussis toxin treatment, supporting an active stromal-derived factor 1 (SDF-1) gradient near endosteum after irradiation...
- CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cellsYu Tzu Tai
LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Blood 113:4309-18. 2009..CS1 overexpression promoted myeloma cell growth and survival by significantly increasing myeloma adhesion to bone marrow stromal cells (BMSCs) and enhancing myeloma colony formation in semisolid culture...
- Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1αYehuda Kamari
The Bert Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel
Biochem Biophys Res Commun 405:197-203. 2011..We assessed whether IL-1α and IL-1β from tissue resident vascular cells or emigrating bone marrow-derived cells promote the development of atherosclerosis in apoE-/- mice and determined the effect of selective ..
- Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to M Z Ratajczak
Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
Leukemia 24:976-85. 2010..which major chemoattractant present in peripheral blood (PB) is responsible for the egress of HSPCs from the bone marrow (BM)...
- Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infectionsAlexander A Navarini
Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 106:7107-12. 2009..These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils are ..
- Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repairAnne Wilson
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
Cell 135:1118-29. 2008b>Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells...
- Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cellsRyo Suzuki
National Institutes of Health, Bethesda, MD 20892 1930, USA
J Leukoc Biol 88:863-75. 2010..This demonstrates that in addition to a role described previously for Orai1 in promoting MC degranulation, nonselective cation channels participate in promoting the exocytotic response...
- The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patientsYanran Cao
Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Exp Hematol 38:860-7. 2010The interaction of multiple myeloma (MM) with its bone marrow (BM) microenvironment is important for the homing pattern, survival, and proliferation of malignant plasma cells...
- Dynamic visualization of thrombopoiesis within bone marrowTobias Junt
Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Science 317:1767-70. 2007Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood...
- HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancerJulie E Lang
Department of Surgical Oncology, MD Anderson Cancer Center, Advanced Research Center for Microscopic Disease, The University of Texas, Houston, TX 77030, USA
Breast Cancer Res Treat 113:501-7. 2009..We hypothesized that primary tumor characteristics would predict the likelihood of identifying CTCs in patients with operable breast cancer...
- Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitisMattias Fransson
Laboratory of Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Lund University, Malmo, Sweden
Respir Res 8:17. 2007Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood...
- Eosinophils are required for the maintenance of plasma cells in the bone marrowVan Trung Chu
Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
Nat Immunol 12:151-9. 2011..It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key ..
- Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxideLee J Goldstein
Department of Surgery, University of Pennsylvania Medical Center, 4th Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, Pennsylvania 19124, USA
Stem Cells 24:2309-18. 2006..to be regulated by hypoxic gradients and induced by vascular endothelial growth factor-mediated increases in bone marrow nitric oxide (NO)...
- Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumorsAndrew C Dudley
Department of Surgery, Harvard Medical School and Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Blood 116:3367-71. 2010The hypothesis that bone marrow-derived, circulating endothelial cells incorporate into tumor blood vessels is unresolved...
- Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in miceCaroline Marty
Inserm U1009, Institut Gustave Roussy, PR1, 114 rue Edouard Vaillant, 94805 Villejuif, France
Blood 116:783-7. 2010..In conclusion, constitutive heterozygous expression of JAK2(V617F) in mice is not embryo-lethal but results in severe PV-like disease with secondary myelofibrosis and not in ET-like disease as expected from patient study...
- Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrowPratibha Singh
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
Stem Cells 26:1009-16. 2008Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved in the immune response...
- Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serologyL Solano-Gallego
Departament de Farmacologia i Terapeutica, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
J Clin Microbiol 39:560-3. 2001..of anti-Leishmania antibodies, and investigated the presence of Leishmania DNA by PCR in skin, conjunctiva, and bone marrow samples of each dog. The prevalence of the disease and the seroprevalence were 13 and 26%, respectively...
- Bone progenitor dysfunction induces myelodysplasia and secondary leukaemiaMarc H G P Raaijmakers
Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School CPZN, USA
Nature 464:852-7. 2010..deletion showed reduced expression of Sbds, the gene mutated in Schwachman-Bodian-Diamond syndrome-a human bone marrow failure and leukaemia pre-disposition condition...
- FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testisB Agerberth
Department of Microbiology, Stockholm University, Sweden
Proc Natl Acad Sci U S A 92:195-9. 1995..peptide antibiotic, has been purified from pig intestine and later shown to originate in the bone marrow. Intending to isolate a clone for a human counterpart to PR-39, we synthesized a PCR probe derived from the PR-..
- SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injectionJianfeng Wang
Department of Hygiene, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyoku, Kyoto, Japan
Blood 101:2924-31. 2003..SCID)- repopulating cells (SRCs) with extensive lymphoid and myeloid repopulating ability using the intra-bone marrow injection (IBMI) technique...
- Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cellsJung Park
Department of Oro-Maxillo-Facial Surgery, University of Erlangen-Nuernberg, Germany
J Gene Med 8:112-25. 2006..METHODS: Mesenchymal cells were isolated from perichondrium/periosteum, bone marrow or fat of adult rats and found to be positive for the stem-cell-related antigens Sca-1, c-Kit, CD10, CD13 and ..
- Analysis of fatty acid composition in human bone marrow aspiratesRyota Deshimaru
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
Keio J Med 54:150-5. 2005In the present study, the fatty acid composition of bone marrow aspirates and serum phospholipids in nine patients with hematologic diseases was investigated, and the effect of fatty acids on osteoblast differentiation in ST2 cells was ..
- Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatmentM J Slade
1Department of Oncology, Imperial College, MRC Cyclotron Building, London W12 0NN, UK
Br J Cancer 100:160-6. 2009..evidence of circulating tumour cells (CTCs) during follow-up as an alternative to monitoring disseminated bone marrow tumour cells (DTCs) by immunocytochemistry and reverse transcriptase (RT)-PCR for the detection of ..
- Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineageMouldy Sioud
Department of Immunology, Radiumhospitalet University Hospital, Oslo, Montebello N 0310, Norway
J Mol Biol 364:945-54. 2006..TLR expression and signaling have been investigated in blood cells, it is currently unknown whether their bone marrow ancestors express TLRs and respond to their ligands. Here we found that TLRs (e.g...
- Pathological changes in the bone marrow of dogs with leishmaniosisV Foglia Manzillo
Dipartimento di Scienze Cliniche Veterinarie, Sezione Clinica Medica, Facolta di Medicina Veterinarie, Via F. Delpino 1, 80137 Naples, Italy
Vet Rec 158:690-4. 2006b>Bone marrow aspiration smears from 15 dogs naturally infected with leishmania were evaluated. Three of the dogs showed no clinical signs, six had up to three clinical signs and six had more than three...
- The genotoxic and cytotoxic effects of nicotine in the mouse bone marrowSabry M Attia
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
Mutat Res 632:29-36. 2007..was to investigate the potential of nicotine to induce micronucleated polychromatic erythrocytes (MNPCE) in bone marrow of male and female mice. Cyclophosphamide at 40mg/kg was used as positive control clastogen...
- Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaBLara F Costa
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Blood 107:285-92. 2006Most bone marrow (BM) malignancies develop in association with an angiogenic phenotype and increased numbers of endothelial cells...
- Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritisEsther Jimenez Boj
Medical University of Vienna, Vienna, Austria
Arthritis Rheum 56:1118-24. 2007To investigate the pathologic nature of features termed "bone erosion" and "bone marrow edema" (also called "osteitis) on magnetic resonance imaging (MRI) scans of joints affected by rheumatoid arthritis (RA).
- Bone marrow edemaGeorg Schett
Department of Internal Medicine 3, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
Ann N Y Acad Sci 1154:35-40. 2009A bone marrow edema pattern on MRI has a similar signal quality as an inflamed synovium and may, in fact, reflect true inflammatory infiltrates rather than a pure accumulation of extracellular fluid...
- Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathologyInes Antunes
Divisions of Immunoregulation, The MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Immunity 29:782-94. 2008Chronic viral infections of the hematopoietic system are associated with bone marrow dysfunction, to which both virus-mediated and immune-mediated effects may contribute...
- Characteristic features of disseminated carcinomatosis of the bone marrow due to gastric cancer: the pathogenesis of bone destructionHiroki Kusumoto
Division of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
Oncol Rep 16:735-40. 2006Disseminated carcinimatosis of the bone marrow is accompanied by solid tumors, and gastric cancer accounts for the majority...
- Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused nichesIngrid G Winkler
Biotherapy Program, Mater Medical Research Institute, South Brisbane, Australia
Blood 116:375-85. 2010Hematopoietic stem cell (HSC) niches have been reported at the endosteum or adjacent to bone marrow (BM) vasculature...
- Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin's lymphoma: a reflection of disease infiltration or just inflammation?Pierre Y Salaun
Nuclear Medicine Department, University Hospital of Brest, Brest, France
Eur J Nucl Med Mol Imaging 36:1813-21. 2009..However, (18)F-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU) are frequently observed at the initial imaging and remain difficult to ..
- Mediastinal follicular dendritic cell sarcoma involving bone marrow: a case report and review of the literatureLiuyan Jiang
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Ann Diagn Pathol 10:357-62. 2006We report a rare case of mediastinal follicular dendritic cell (FDC) sarcoma involving the bone marrow. The patient, a 46-year-old woman, had a clinically aggressive tumor in the anterior mediastinum that was initially diagnosed as a ..
- cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitorsPolina Goichberg
Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
Blood 107:870-9. 2006..of the effects of cAMP-elevating agents revealed an increased ability of human CD34+ cells to transmigrate the bone marrow (BM) endothelial layer and adhere to BM stroma in vitro, and it augmented the homing potential to the BM and ..
- Volumetric and semiquantitative assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis: a comparison of contrast-enhanced and non-enhanced imagingF W Roemer
Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
Osteoarthritis Cartilage 18:1062-6. 2010Aim was to compare volumetric and semi-quantitative (SQ) measurements of subchondral bone marrow lesions (BMLs) on non-fat-suppressed (FS) T1-weighted (w), T1-w FS contrast enhanced (CE) and proton density (PD)-w FS images in order to ..
- Rotary powered device for bone marrow aspiration and biopsy yields excellent specimens quickly and efficientlyRonan T Swords
University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
J Clin Pathol 63:562-5. 2010Recently, a new FDA-cleared battery powered bone marrow biopsy system was developed to allow operators access to the bone marrow space quickly and efficiently...
- Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 monthsShigeyuki Wakitani
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Japan
J Tissue Eng Regen Med 5:146-50. 2011Among autologous somatic stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) are the most widely used worldwide to repair not only mesenchymal tissues (bone, cartilage) but also many other kinds of tissues, including heart, ..
- Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal modelsYusuke Suzuki
Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
Semin Nephrol 28:66-77. 2008Impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role in the pathogenesis of IgA nephropathy. Animal models have allowed us to study such changes in detail...
- Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposureBenjamin C Moeller
Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7431, United States
Chem Res Toxicol 24:162-4. 2011The presence of endogenous and exogenous N(2)-hydroxymethyl-dG adducts in DNA from the nasal mucosa and bone marrow of cynomolgus macaques exposed to 1.9 and 6...
- Anti-leukemic effect of graft-versus-host disease on bone marrow and extramedullary relapses in acute leukemiaJe Hwan Lee
Department of Internal Medicine, Asan Medical Center, 388 1 Poongnap 2 dong, Songpa Gu, Seoul 138 736, Korea
Haematologica 90:1380-8. 2005..that the graft-versus-leukemia effect at extramedullary (EM) sites might be less prominent than that in the bone marrow (BM)...
- Factors released from cholestatic rat livers possibly involved in inducing bone marrow hepatic stem cell primingJun Xu
Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Stem Cells Dev 17:143-55. 2008Previous studies have shown that bone marrow beta 2m(-)/Thy-1+ hepatic stem cells (BMHSCs) were able to engraft in vivo and differentiate into functioning hepatocytes in vitro...
- Gene expression analysis of major lineage-defining factors in human bone marrow cells: effect of aging, gender, and age-related disordersYing Jiang
Nanotechnology Research Institute NRI, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
J Orthop Res 26:910-7. 2008Adult bone marrow cells (BMCs) include two populations:;mesenchymal stem cells (MSCs), which can differentiate into bone, cartilage, and fat; and hematopoietic stem cells (HSCs), which produce all mature blood lineage...
- Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cellsAtsuko Masumi
Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan
FEBS Lett 583:3493-500. 2009..investigate the role of interferon regulatory factors (IRFs) in inflammation-associated megakaryopoiesis, mouse bone marrow hematopoietic stem cells (HSCs) were analyzed...
- Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cellsYong Wang
Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA
Free Radic Biol Med 48:348-56. 2010..and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM) injury...
- Clinical outcome of gastric cancer patients with bone marrow metastasesHyo Song Kim
Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Oncology 73:192-7. 2007Gastric cancer with bone marrow metastases is known to pursue a rapidly deteriorating clinical course...
- The acutely ACL injured knee assessed by MRI: changes in joint fluid, bone marrow lesions, and cartilage during the first yearR B Frobell
Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Osteoarthritis Cartilage 17:161-7. 2009..the first year after acute rupture of the anterior cruciate ligament (ACL) of volumes of joint fluid (JF), bone marrow lesions (BMLs), and cartilage volume (VC), and cartilage thickness (ThCcAB) and cartilage surface area (AC)...
- Intra-bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr miceT Kushida
First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan
Blood 97:3292-9. 2001Intractable autoimmune diseases in chimeric resistant MRL/lpr mice were treated by a new bone marrow transplantation (BMT) method consisting of fractionated irradiation, 5...
- Rescue of lethally irradiated mice from hematopoietic death by pre-exposure to 0.5 Gy X rays without recovery from peripheral blood cell depletion and its modification by OK432M Nose
Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, 263-8555, Japan
Radiat Res 156:195-204. 2001..These results suggest that radioresistance induced by pre-exposure to 0.5 Gy X rays is not stable, but rather varies with the physiological conditions, and can be modulated by factors such as OK432...
- Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapyCynthia A Presley
Hoxworth Blood Center, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
Cell Commun Adhes 12:307-17. 2005Contact between bone marrow (BM) hematopoietic stem cells (HSC) and osteoblast/stromal (OS) cells has been shown to be crucial in the regulation of hematopoiesis...
- Production of human B cells from CD34+CD38- T- B- progenitors in organ culture by sequential cytokine stimulationDominick Deluca
Department of Microbiology and Immunology, Life Sciences North Room 648, Tucson, AZ 84724 5049, USA
Dev Comp Immunol 30:1084-98. 2006..on human hematopoietic stem cell (HSC) differentiation in murine fetal liver (FL), fetal spleen (FS) and bone marrow (BM) organ cultures (OC)...
- Gamma 2b provides only some of the signals normally given via mu in B cell developmentB S Kurtz
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA
Int Immunol 9:415-26. 1997..Comparison of conventional gamma 2b transgenics with the C line and mu transgenics reveals the multiple signals required throughout B cell development...
- Il-7 receptor signaling in lymphopoiesisMotonari Kondo; Fiscal Year: 2009..IL-7 plays a critical role in regulation of EBF expression at an early phase of B cell development in adult bone marrow. Dysfunction of IL-7 receptor subunits (either 11-7 receptor alpha or common gamma chains) causes profound ..
- GENETIC ANALYSIS OF POLARITYRuth Steward; Fiscal Year: 2009..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
- DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY SUSCEPTIBILITY EFFECTS IN MRINir Barzilai; Fiscal Year: 1999..The change in oxygen saturation in sickle cell patients in brain and bone marrow was investigated while the patient was breathing room air or high oxygen through a face mask and comparing the ..
- BONE MARROW TRANSPLANTION AND ATHEROSCLEROSISMacRae Linton; Fiscal Year: 1999..The goal of this project is to use murine bone marrow transplantation as a method to investigate the role of the macrophage in atherosclerosis and lipoprotein ..
- Stem cells in liver regeneration: fusion or plasticityBryon E Petersen; Fiscal Year: 2010..Several studies have shown that bone marrow cells can differentiate into hepatocytes, and we have also shown that bone marrow (BM) cells are able to ..
- Myxoma Virus (MV) Oncolysis for treating human cancerGrant McFadden; Fiscal Year: 2010..therapeutic strategy for which the virus is uniquely well-suited: ex vivo purging of cancer cells within human bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell ..
- Immune response to Pneumocystis and bone marrow failureNicole Meissner; Fiscal Year: 2010..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
- Immune response to Pneumocystis and bone marrow failureNicole Meissner; Fiscal Year: 2009..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
- G-CSF RECEPTOR AND PROGENITOR MOBILIZATIONDaniel Link; Fiscal Year: 2003..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
- Correction of neural abnormalities in Hurler syndromePankaj Gupta; Fiscal Year: 2003..neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
- PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESISELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2002Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
- Stem Cell Transplantation for Hemoglobinopathies in DogsJOHN HEARST; Fiscal Year: 2003b>Bone marrow transplantation has the potential of providing a complete cure of the disease symptoms of hemoglobinopathies...
- Cord Blood Stem Cell Transplantation, HemoglobinopathiesJOHN HEARST; Fiscal Year: 2003b>Bone marrow transplantation has the potential of providing a complete cure of the disease symptoms of hemoglobinopathies...
- Ribosome Biogenesis in Diamond Blackfan AnemiaMonica Bessler; Fiscal Year: 2007Our laboratory has a longstanding interest in the molecular pathogenesis of bone marrow failure, a condition characterized by the inability of the bone marrow to produce sufficient blood cells...
- Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth CancersJOHN MARTIN BROWN; Fiscal Year: 2010..to cure these tumors despite high dose radiotherapy is the result of regrowth of the tumor vasculature from bone marrow derived cells (BMDCs) following the course of radiotherapy...
- Stem Cells and Ischemic Brain InjuryWalter Low; Fiscal Year: 2003Studies of bone marrow cells have shown that they can restore neurologic function when transplanted into animals with ischemic brain injury...
- Bone Marrow Angioblasts for Myocardial VasculogenesisSilviu Itescu; Fiscal Year: 2006..We have recently shown that human adult bone marrow contains endothelial progenitors with phenotypic and functional characteristics of embryonic hemangioblasts, ..
- IMPROVED CONDITIONS FOR HUMAN HEMATOPOIETIC CELL CULTUREELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 1993Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
- THE THERAPY OF AMLMichael Andreeff; Fiscal Year: 2007..Only 10-20 percent are cured by combination chemotherapy. Although allogeneic bone marrow transplantation is potentially curative, only 25 percent of AML patients are eligible for this therapy and only ..
- The Pathogenesis of Dyskeratosis CongenitaPhilip J Mason; Fiscal Year: 2010The long-term goal of this work is to understand the pathogenesis of the rare bone marrow failure syndrome dyskeratosis ongenital (DC) and the reasons for its predisposition to malignancy...
- STUDIES ON THE REGULATION OF OSTEOCLAST PRECURSOR CELLSJoseph A Lorenzo; Fiscal Year: 2010..Currently, it is unknown whether osteoclast precursor cells, which originate in bone marrow, 1) migrate directly from bone marrow to adjacent bone, where they mature and function as resorbing cells or if ..