bone marrow

Summary

Summary: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Top Publications

  1. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
  2. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
  3. doi Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Cell 135:1118-29. 2008
  4. ncbi Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    Teru Hideshima
    Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Nat Rev Cancer 7:585-98. 2007
  5. pmc The bone marrow niche for haematopoietic stem cells
    Sean J Morrison
    Howard Hughes Medical Institute, Children s Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 505:327-34. 2014
  6. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
  7. doi Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells
    Marius Strioga
    Department of Immunology, Center of Oncosurgery, Institute of Oncology, Vilnius University, Vilnius, Lithuania
    Stem Cells Dev 21:2724-52. 2012
  8. pmc CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    Adam Greenbaum
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 495:227-30. 2013
  9. pmc Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 457:92-6. 2009
  10. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002

Detail Information

Publications345 found, 100 shown here

  1. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals...
  2. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
    ..MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling ..
  3. doi Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Cell 135:1118-29. 2008
    b>Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells...
  4. ncbi Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    Teru Hideshima
    Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Nat Rev Cancer 7:585-98. 2007
    ..The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies...
  5. pmc The bone marrow niche for haematopoietic stem cells
    Sean J Morrison
    Howard Hughes Medical Institute, Children s Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 505:327-34. 2014
    ..Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but ..
  6. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
    ..hematopoietic stem cells through the blood, across the endothelial vasculature to different organs and to their bone marrow (BM) niches, requires active navigation, a process termed homing...
  7. doi Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells
    Marius Strioga
    Department of Immunology, Center of Oncosurgery, Institute of Oncology, Vilnius University, Vilnius, Lithuania
    Stem Cells Dev 21:2724-52. 2012
    ..MSCs are found in virtually all organs of the body. Bone marrow-derived MSCs (BM-MSCs) were discovered first, and the bone marrow was considered the main source of MSCs for ..
  8. pmc CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    Adam Greenbaum
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 495:227-30. 2013
    Haematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation and trafficking...
  9. pmc Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 457:92-6. 2009
    ..confocal microscopy and two-photon video imaging of individual haematopoietic cells in the calvarium bone marrow of living mice over time, we examine the relationship of haematopoietic stem and progenitor cells to blood ..
  10. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..a reduction of the chemokine stromal cell derived factor 1 (SDF-1) and an increase in its receptor CXCR4 in the bone marrow (BM), whereas their protein expression in the blood was less affected...
  11. doi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..HSCs and their progenitors fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment...
  12. ncbi Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    Andrea Augello
    Laboratory of Regenerative Medicine, National Institute for Cancer Research, Genova, Italy
    Eur J Immunol 35:1482-90. 2005
    b>Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation...
  13. ncbi Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
    Mesenchymal stem cell populations have previously been identified in adult bone marrow and dental pulp that are capable of regenerating the bone marrow and dental pulp microenvironments, respectively...
  14. pmc Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
    Lei Ding
    Howard Hughes Medical Institute, Children s Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nature 495:231-5. 2013
    ..Different stem and progenitor cells thus reside in distinct cellular niches in bone marrow: HSCs occupy a perivascular niche and early lymphoid progenitors occupy an endosteal niche.
  15. pmc Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment
    César Nombela-Arrieta
    Division of Transfusion Medicine, Department of Laboratory Medicine, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA corrected
    Nat Cell Biol 15:533-43. 2013
    ..on the notion that haematopoietic stem and progenitor cells (HSPCs) are strategically positioned in unique bone marrow microenvironments with defined anatomical and functional features...
  16. doi Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 7:391-402. 2010
    ..Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM)...
  17. pmc Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment
    Zhihong Zeng
    Departments of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 120:2679-89. 2012
    The interactions between the bone marrow (BM) microenvironment and acute myeloid leukemia (AML) is known to promote survival of AML cells...
  18. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010
    ..Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal ..
  19. pmc Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    R R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Exp Med 173:1213-25. 1991
    We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1 (heat stable antigen)...
  20. pmc Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells
    Andrea T Hooper
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Stem Cell 4:263-74. 2009
    Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how regeneration of bone marrow vessels contributes to engraftment of transplanted hematopoietic stem and progenitor cells (HSPCs) and restoration of ..
  21. doi Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
    ..Here we identified NCSCs in the bone marrow (BM), dorsal root ganglia, and whisker pad and prospectively isolated them from adult transgenic mice encoding ..
  22. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum...
  23. pmc Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche
    Koen Schepers
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Division of Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 13:285-99. 2013
    Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance...
  24. ncbi Targeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: an alternative to standard total body irradiation
    Jeffrey Y C Wong
    Division of Radiation Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
    Biol Blood Marrow Transplant 12:306-15. 2006
    Total body irradiation (TBI) is an important part of bone marrow transplantation conditioning regimens. In TBI, dose escalation is difficult, because of associated normal organ toxicities...
  25. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..and that although the numbers of B-cell progenitors in mutant embryos were severely reduced in fetal liver and bone marrow, myeloid progenitors were reduced only in the bone marrow but not in the fetal liver, indicating that PBSF/SDF-..
  26. pmc Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
    Craig D Jude
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, 725 Remsen, HB7400, Hanover, NH 03755, USA
    Cell Stem Cell 1:324-37. 2007
    ..model, we demonstrate that Mll is essential for the maintenance of adult HSCs and progenitors, with fatal bone marrow failure occurring within 3 weeks of Mll deletion...
  27. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
    ..In mammals, the best understood niche is that harboring bone marrow hematopoietic stem cells (HSCs)...
  28. ncbi Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice
    Matthias Schilling
    Dept of Neurology, Universitatsklinikum Munster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Exp Neurol 196:290-7. 2005
    ..In this study, we used green fluorescent protein (GFP) transgenic bone marrow chimeric mice and semithin serial sections after methyl methacrylate embedding of the brains to dissect in ..
  29. pmc CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 113:4341-51. 2009
    The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents...
  30. ncbi Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..diabetes, circulating EPCs were reduced to 39 +/- 5% of controls and associated with uncoupled eNOS in bone marrow. Our results identify uncoupling of eNOS in diabetic bone marrow, glucose-treated EPCs, and EPCs from diabetic ..
  31. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ..evidence that the SDF-1alpha/CXCR4 chemokine axis is involved in both the retention of neutrophils within the bone marrow and the homing of senescent neutrophils back to the bone marrow...
  32. pmc HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy
    Christine M Durand
    Department of Medicine, The Sidney Kimmel CancerCenter, USA
    J Infect Dis 205:1014-8. 2012
    ..We obtained bone marrow aspirates from 11 patients on ART who had undetectable plasma HIV-1 RNA...
  33. pmc Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
    Matthew J Christopher
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 114:1331-9. 2009
    ..cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone ..
  34. ncbi A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow
    Robert F Wynn
    Stem Cell Research Group and Willink Biochemical Genetics Unit, Royal Manchester Children s Hospital, Manchester, United Kingdom
    Blood 104:2643-5. 2004
    Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency...
  35. ncbi Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice
    O Kollet
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Blood 97:3283-91. 2001
    ..combined immunodeficient (SCID) repopulating cells home and accumulate rapidly, within a few hours, in the bone marrow and spleen of immunodeficient mice previously conditioned with total body irradiation...
  36. ncbi Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
    Fumihiko Ishikawa
    Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho Tsurumi ku, Yokohama 230 0045, Japan
    Nat Biotechnol 25:1315-21. 2007
    ..They home to and engraft within the osteoblast-rich area of the bone marrow, where AML cells are protected from chemotherapy-induced apoptosis...
  37. ncbi Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Daniel J Ceradini
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Nat Med 10:858-64. 2004
    ..The chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12) mediates homing of stem cells to bone marrow by binding to CXCR4 on circulating cells...
  38. doi Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
    Satoshi Yamazaki
    Japan Science and Technology Agency, ERATO, Chiyoda ku, Tokyo 102 0075, Japan
    Cell 147:1146-58. 2011
    Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial...
  39. pmc Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
    Sebastian Stier
    Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 201:1781-91. 2005
    ..for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment...
  40. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..plasma cells are nonrecirculatory and lodge in splenic red pulp, lymph node medullary cords, and bone marrow. The factors that regulate plasma cell localization are poorly defined...
  41. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  42. doi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
    ..Contradictory results with bone marrow (BM)-derived MSCs have initiated a comprehensive comparison of HS, tPRP, and pooled human platelet lysate (pHPL)..
  43. ncbi Dynamic visualization of thrombopoiesis within bone marrow
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 317:1767-70. 2007
    Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood...
  44. doi Subsets, expansion and activation of myeloid-derived suppressor cells
    Eliana Ribechini
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, Wurzburg, Germany
    Med Microbiol Immunol 199:273-81. 2010
    ..Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites...
  45. pmc Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:590-601. 2011
    ..Monocytes originate from bone marrow and their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic ..
  46. ncbi Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family
    T J Fleming
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    J Immunol 151:2399-408. 1993
    ..FACS analysis using 1A8 demonstrated that Ly-6G was expressed in bone marrow but not substantially on other lymphoid tissues, including activated T and B cells...
  47. doi Detection of functional haematopoietic stem cell niche using real-time imaging
    Yucai Xie
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nature 457:97-101. 2009
    ..HSCs home to bone marrow through the vascular system...
  48. pmc Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    Marc H G P Raaijmakers
    Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School CPZN, USA
    Nature 464:852-7. 2010
    ..deletion showed reduced expression of Sbds, the gene mutated in Schwachman-Bodian-Diamond syndrome-a human bone marrow failure and leukaemia pre-disposition condition...
  49. pmc Redox regulation of stem/progenitor cells and bone marrow niche
    Norifumi Urao
    Department of Pharmacology, Center for Lung and Vascular Biology, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL 60612, USA
    Free Radic Biol Med 54:26-39. 2013
    b>Bone marrow (BM)-derived stem and progenitor cell functions including self-renewal, differentiation, survival, migration, proliferation, and mobilization are regulated by unique cell-intrinsic and -extrinsic signals provided by their ..
  50. pmc Arteriolar niches maintain haematopoietic stem cell quiescence
    Yuya Kunisaki
    1 Ruth L and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA 2 Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 502:637-43. 2013
    ..stromal cells have been identified as potential HSC niches, the spatial localization of quiescent HSCs in the bone marrow remains unclear...
  51. ncbi Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells
    G J Spangrude
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840
    Blood 82:3327-32. 1993
    ..Therefore, strain-specific variation in Ly-6A/E expression by bone marrow (BM) cells was investigated...
  52. pmc Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation
    Chen S Tan
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 199:881-8. 2009
    We sought to determine the prevalence of JC virus (JCV) in bone marrow samples from human immunodeficiency virus (HIV)-positive and HIV-negative patients and to determine whether bone marrow is a site of latency and neurotropic ..
  53. pmc Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction
    Zhuzhi Wen
    The Sun Yat sen Memorial Hospital of Sun Yat sen University, Guangzhou, China
    J Cell Mol Med 15:1032-43. 2011
    ..b>Bone marrow-derived mesenchymal stem cells (MSCs) hold promise for cardiac repair following MI, due to their multilineage, ..
  54. ncbi Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1
    P J Simmons
    Department of Medical Oncology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Blood 78:55-62. 1991
    Murine IgM monoclonal antibody STRO-1 identifies a cell surface antigen expressed by stromal elements in human bone marrow (BM)...
  55. pmc Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression
    Hongliang Li
    Institute of Radiation Medicine, Department of Biochemistry and Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    Free Radic Biol Med 51:30-7. 2011
    Our recent studies showed that total body irradiation (TBI) induces long-term bone marrow (BM) suppression in part by induction of hematopoietic stem cell (HSC) senescence through reactive oxygen species (ROS)...
  56. pmc The bone marrow at the crossroads of blood and immunity
    Francois E Mercier
    Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 12:49-60. 2012
    Progenitor cells that are the basis for all blood cell production share the bone marrow with more mature elements of the adaptive immune system...
  57. doi Awakening dormant haematopoietic stem cells
    Andreas Trumpp
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
    Nat Rev Immunol 10:201-9. 2010
    Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells...
  58. doi Thymic and bone marrow output in patients with common variable immunodeficiency
    Federico Serana
    Department of Biomedical Science and Biotechnology, University of Brescia, Brescia, Italy
    J Clin Immunol 31:540-9. 2011
    ..The study aims to obtain more information about the immune deficit of common variable immunodeficiency (CVID) patients...
  59. doi Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells
    Angela Colmone
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA
    Science 322:1861-5. 2008
    ..imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments that sequester transplanted human CD34+ (HPC-enriched) cells...
  60. pmc Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction
    Ewa K Zuba-Surma
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    J Cell Mol Med 15:1319-28. 2011
    Adult bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) exhibit a Sca-1(+)/Lin(-)/CD45(-) phenotype and can differentiate into various cell types, including cardiomyocytes and endothelial cells...
  61. doi Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis
    Una Riekstina
    Faculty of Medicine, University of Latvia, Riga LV 1001, Latvia
    Stem Cell Rev 5:378-86. 2009
    Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues, e.g., bone marrow, adipose tissue, dermis, hair follicles, heart, liver, spleen, dental pulp...
  62. doi CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
    Haematologica 93:423-30. 2008
    ..about the number and function of immunosuppressive CD4(+)CD25(+)FOXP3(+) T regulatory cells (Treg) in the human bone marrow and it is unclear whether bone marrow-residing Treg are capable of regenerating following allogeneic stem cell ..
  63. doi The bone marrow: a site of neutrophil clearance
    Sara M Rankin
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, Exhibition Rd, London, SW7 2AZ, UK
    J Leukoc Biol 88:241-51. 2010
    ..current dogma that neutrophils are cleared primarily in the liver and spleen, presenting the evidence that the bone marrow is also an important site of neutrophil clearance under homeostatic conditions...
  64. pmc Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow
    Steven G DuBois
    Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94143 0106, USA
    Pediatr Blood Cancer 54:13-8. 2010
    ..A new method for detecting circulating Ewing sarcoma cells using flow cytometry is described. This strategy exploits the nearly universal expression of CD99 and the lack of expression of CD45 by Ewing sarcoma cells...
  65. doi Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:3330-7. 2010
    The significance of circulating tumor cells (CTCs) in blood and of disseminated tumor cells (DTCs) in bone marrow (BM) in patients with early stage breast cancer is unclear...
  66. pmc A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    Kimberly Noonan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Blood 116:3554-63. 2010
    ..Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances ..
  67. ncbi Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova 15145, Italy
    Stem Cells 26:151-62. 2008
    Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating neutrophils...
  68. doi CXCL12 and CXCR4 in bone marrow physiology
    Natalia M Moll
    CRICM INSERM UPMC, UMRS 975 CNRS UMR 7225, Faculte de Medecine Pierre et Marie Curie, Hopital Pitie Salpetriere, 105 bd de l Hopital, 75634 Paris, France
    Expert Rev Hematol 3:315-22. 2010
    This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation...
  69. doi Neutrophils, from marrow to microbes
    Niels Borregaard
    The Granulocyte Research Laboratory, Department of Hematology, National University Hospital Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Immunity 33:657-70. 2010
    Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules...
  70. pmc Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:691-9. 2011
    ..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
  71. ncbi Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury
    Jie Ma
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Acaademy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Haematologica 92:889-96. 2007
    ..senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchymal stem cells (MSC)...
  72. pmc Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to
    M Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 24:976-85. 2010
    ..which major chemoattractant present in peripheral blood (PB) is responsible for the egress of HSPCs from the bone marrow (BM)...
  73. ncbi Microenvironmental niches in the bone marrow required for B-cell development
    Takashi Nagasawa
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Rev Immunol 6:107-16. 2006
    ..This article summarizes the recent advances in research on the earliest B-cell precursors, their requisite environmental factors and the cellular niches that supply these factors and maintain B cells during their development...
  74. ncbi Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow
    Katia Mareschi
    Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
    J Cell Biochem 97:744-54. 2006
    ..We isolated and expanded MSCs from bone marrow (BM) of pediatric and young adult donors, to analyze the growth kinetic, immunophenotype, telomere length, ..
  75. doi Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis
    Wolfgang Janni
    Frauenklinik der Heinrich Heine Universität, Dusseldorf, Germany
    Clin Cancer Res 17:2967-76. 2011
    The prognostic significance of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a large pooled analysis...
  76. ncbi The bone marrow vascular niche: home of HSC differentiation and mobilization
    Hans Georg Kopp
    Weill Medical College of Cornell University, New York, New York, USA
    Physiology (Bethesda) 20:349-56. 2005
    The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells...
  77. pmc Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi
    A B Reis
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Departamento de Análises Clínicas Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil
    Clin Exp Immunol 146:303-11. 2006
    ..Herein, we have assessed the correlation between the clinical status as well as the impact of bone marrow parasite density on the phenotypic profile of peripheral blood leucocytes in 40 Brazilian dogs naturally ..
  78. pmc Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3
    I Vande Broek
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Laarbeeklaan 101, Belgium
    Br J Cancer 88:855-62. 2003
    The restricted bone marrow (BM) localisation of multiple myeloma (MM) cells most likely results from a specific homing influenced by chemotactic factors, combined with the proper signals for growth and survival provided by the BM ..
  79. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive...
  80. doi The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance
    Mark B Meads
    Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Clin Cancer Res 14:2519-26. 2008
    The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells...
  81. ncbi Adult rat and human bone marrow stromal cells differentiate into neurons
    D Woodbury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 61:364-70. 2000
    b>Bone marrow stromal cells exhibit multiple traits of a stem cell population. They can be greatly expanded in vitro and induced to differentiate into multiple mesenchymal cell types...
  82. ncbi Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture
    W J C Rombouts
    Department of Haematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Leukemia 17:160-70. 2003
    Recent studies describe beneficial effects of bone marrow-derived mesenchymal stem cell infusion in animal models as well as in patients. However, data on the homing abilities of primary and culture-expanded MSC are lacking...
  83. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    ..The transgenic offspring showed an almost complete lack of bone marrow in newborns, owing to strongly retarded vascular invasion into hypertrophic cartilage and impaired cartilage ..
  84. ncbi An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
    ..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
  85. pmc Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression
    Dingcheng Gao
    Department of Cardiothoracic Surgery, Lehman Brothers Lung Cancer Research Center, Cornell University Medical Center, New York, NY 10065, USA
    Biochim Biophys Acta 1796:33-40. 2009
    Emerging evidence indicates that bone marrow (BM)-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated growth of certain tumors in mice and human...
  86. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  87. doi Tumor microenvironment: bone marrow-mesenchymal stem cells as key players
    Pedro Barcellos-de-Souza
    Department of Experimental and Clinical Biomedical Sciences, University of Florence, Tuscany Tumor Institute and Center for Research, Transfer and High Education DENOthe, Florence, Italy CAPES Foundation, Ministry of Education of Brazil, Brasilia, DF, Brazil Electronic address
    Biochim Biophys Acta 1836:321-35. 2013
    ..Among several cell types that constitute the tumor stroma, the discovery that bone marrow-derived mesenchymal stem cells (BM-MSC) have a strong tropism for tumors has achieved notoriety in recent years...
  88. pmc Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells
    Yong Wang
    Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA
    Free Radic Biol Med 48:348-56. 2010
    ..and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM) injury...
  89. pmc The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs)
    Magda Kucia
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Age (Dordr) 35:315-30. 2013
    ..demonstrate that a population of murine pluripotent very small embryonic-like stem cells (VSELs) that reside in bone marrow (BM) is protected from premature depletion during aging by intrinsic parental gene imprinting mechanisms and ..
  90. ncbi A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation
    Tanja Fehm
    Department of Obstetrics and Gynecology, University of Tubingen, Tubingen, Germany
    Cancer 107:885-92. 2006
    ..and a large pooled analysis have demonstrated that the presence of disseminated tumor cells (DTCs) in the bone marrow (BM) from patients with primary, nonmetastatic breast cancer (Stages I-III) is associated with impaired ..
  91. pmc Bone marrow microenvironment and the identification of new targets for myeloma therapy
    K Podar
    Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics, Dana Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Boston, MA 02115, USA
    Leukemia 23:10-24. 2009
    ..both early and late genetic changes in the tumor cell as well as selective supportive conditions by the bone marrow (BM) microenvironment...
  92. pmc Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
    C Berlin-Rufenach
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
    J Exp Med 189:1467-78. 1999
    ..interacting with ligand VCAM-1, and also LFA-1 participate in substantial lymphocyte recirculation through bone marrow. These observations suggest that organ-specific adhesion receptor usage in mature lymphocyte recirculation is ..
  93. pmc Bone marrow-derived myofibroblasts are the providers of pro-invasive matrix metalloproteinase 13 in primary tumor
    Julie Lecomte
    Laboratory of Tumor and Development Biology, GIGA Cancer, University of Liege, Liege, Belgium
    Neoplasia 14:943-51. 2012
    ..In the present report, we have explored the contribution of bone marrow (BM)-derived cells to generate different fibroblast subsets that putatively produce the matrix ..
  94. pmc Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications
    Karina T Wright
    Spinal Studies and Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Stem Cells 29:169-78. 2011
    Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies...
  95. doi Bone marrow-derived mesenchymal stem cells enhanced diabetic wound healing through recruitment of tissue regeneration in a rat model of streptozotocin-induced diabetes
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Plast Reconstr Surg 128:872-80. 2011
    This study investigated whether bone marrow-derived mesenchymal stem cell therapy has effectiveness in the enhancement of diabetic wound healing through tissue regeneration.
  96. pmc The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse
    Rebecca C Furze
    Leukocyte Biology Section, Sir Alexander Fleming Building, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK SW7 2AZ
    FASEB J 22:3111-9. 2008
    In humans, 10(11) neutrophils are released from the bone marrow per day, and these cells have a half-life in the blood of only approximately 6.5 h...
  97. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
    B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not...
  98. ncbi Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    Scott T Avecilla
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 10:64-71. 2004
    ..Here we report that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production...
  99. doi Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations
    Shuei Liong Lin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:6733-43. 2009
    ..three distinct subpopulations defined by the marker Ly6C, all of which are derived from a single Ly6C(high) bone marrow monocyte population selectively recruited to the kidney...
  100. doi Eosinophils are required for the maintenance of plasma cells in the bone marrow
    Van Trung Chu
    Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
    Nat Immunol 12:151-9. 2011
    ..It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key ..
  101. pmc Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer
    A Daskalaki
    Department of Pathology, University General Hospital of Heraklion, Crete 71110, Greece
    Br J Cancer 101:589-97. 2009
    ..rates and evaluate the clinical relevance of cytokeratin-19 (CK-19) mRNA-positive cells in the peripheral blood (circulating tumour cells, CTCs) and bone marrow (disseminated tumour cells; DTCs) of patients with early breast cancer.

Research Grants119 found, 100 shown here

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow. The recipient's bone marrow can then produce new blood cells...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow. The recipient's bone marrow can then produce new blood cells...
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..basophils, and fibrocytes;and that those cells in turn influence sinus associated lymphatic tissue, bone marrow, and the lungs...
  4. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..the bone deficits in HSCT survivors stems from the inverse relation between bone and fat formation within the bone marrow cavity, where hormones and transcription factors regulate mesenchyme stem cell (MSC) differentiation into ..
  5. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..investigation for treatment of numerous autoimmune and inflammatory diseases, and as anti-rejection agents in bone marrow and solid organ transplantation...
  6. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..will also examine the effector function of memory B cells in peripheral blood, broncho-alveolar lavage (BAL), bone marrow (BM), small intestine and lymph node tissues from SIV infected macaques...
  7. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..The alternatives are recipient MSC, which would require bone marrow aspiration and MSC expansion/banking while the recipient is on the waiting list, or MSC from a third party...
  8. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..A slight shortening of red cell survival creates a demand for a small increase in red cell production by the bone marrow. The marrow cannot respond adequately to this demand due to impaired erythropoiesis and impaired mobilization ..
  9. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..To test this, 1) bone marrow transplants, co-cultures and cytokine analyses will confirm the altered marrow environment and identify the COJ ..
  10. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
  11. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure...
  12. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..effect on protection and healing of small intestine in irradiated mice with particular attention on the role of bone marrow-derived cells...
  13. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..b>Bone marrow or stem cell transplantation can be a life-saving procedure for individuals with certain types of blood cancers...
  14. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..Aim2. To develop a pig hosting a human immune system. Aim 2a. We will utilize human/or swine bone marrow hematopoietic stem cells (HSC) to repopulate the immune system by injecting into a developing fetus prior to ..
  15. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..The bone marrow - a red, spongy material found within the cavities of many of large bones - makes hemoglobin...
  16. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    ..B19V replication is highly restricted to human erythroid progenitor cells (EPCs) in the bone marrow and fetal liver...
  17. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..GSK-3 during pressure overload-induced cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on novel connections between GSK-3 isoforms and their ..
  18. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..First, ICSBP-expression is decreased in bone marrow samples from subjects with myelodysplastic syndrome (MDS) and chronic myeloid leukemia (CML)...
  19. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..cells, or both is required for release of soluble factors from the tumor which recruit additional MDSC from the bone marrow and drive their infiltration into the tumor...
  20. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..VIVO Protection of antisera or affinity pure anti-C(2-3L from different species will be tested on human Fc(RI(+ bone marrow-derived mast cells from tg mice, and human mast cells in vitro...
  21. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..Anemia Research Fund Scientific Symposium Fanconi anemia (FA) is a rare hereditary disease characterized by bone marrow failure, developmental anomalies, a high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML)..
  22. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a rare hereditary disease characterized by bone marrow failure, developmental anomalies, high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid ..
  23. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..cells recovered by the RIA are more abundant and more osteogenic than marrow cells recovered by traditional bone marrow aspiration...
  24. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..e., trigeminal ganglion) or cornea, both resident and bone marrow-derived cells with a functional type I IFN pathway are required to maximize resistance to infection...
  25. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..In this grant I wil study the function of a genetic variant associated with multiple autoimmune diseases, the PTPN22 1858T variant, to examine its role in immune responses and disease pathogenesis. ..
  26. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..Because transplant recipients are "rescued" from the bone marrow suppressing effects of the pre-transplant conditioning regimen by the subsequent infusion of healthy stem cells,..
  27. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..Over 20 cancer types express CXCR4 and metastasize to tissues that secrete SDF1, including bone marrow, lung, liver and lymph nodes...
  28. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..This general system is stimulation of unfractionated bone marrow aspirates with cytokines and measuring the fine kinetics of modified epitopes on signaling proteins by ..
  29. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..We found a Gas2-dependent decrease in calpain activity and increase in bcatenin in Bcr-abl+ or Icsbp-/- murine bone marrow cells. Stat3, Stat5 and Xiap proteins are also increased in Icsbp-/- cells in a Gas2/calpain-dependent manner...
  30. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..In Aim 1 we will determine the location from which the recruited cells arise, specifically the bone marrow and brain contribution...
  31. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ....
  32. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..b>Bone marrow mesenchymal stem cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone ..
  33. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..on PGE2-mediated HSC growth and proliferation will enable targeted therapeutic approaches for the treatment of bone marrow failure states, recovery from chemotherapy, or after HSC transplant...
  34. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Changes in blood and bone marrow cell compositions as well as phagocyte infiltration into lung, spleen and liver will be tested following sepsis ..
  35. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..Arg2-/-iNOS-/- double knockout mice that will be compared to wild-type (WT), Arg2-/-, and iNOS-/- mice, and bone marrow chimeras will be used, to examine A) H...
  36. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ..In Aim 3, we will delineate the cardiac and bone marrow (BM)-related effects by which GTSP modulates neovascularization in the failing heart...
  37. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
    ..the School of Medicine, participation in national conferences including DDW, FASEB, and AAI, and instruction in bone marrow transfer, flow cytometry, and laser capture microdissection...
  38. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..Bone-forming osteoblasts originate from mesenchymal stromal cells (MSCs) in the bone marrow (BM)...
  39. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses. ..
  40. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..Several syndromes of T cell-mediated bone marrow failure have similar pathology including aplastic anemia (AA), paroxysmal nocturnal hemaglobinuria (PNH), and a ..
  41. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..mice was accompanied by increased serum markers of bone resorption and increased osteoclast numbers in ex-vivo bone marrow cultures...
  42. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..I have preliminary data demonstrating metabolic changes, including adipose redistribution to liver and bone marrow, accompanied by reduced trabecular bone mineral density in mice treated with risperidone, one of the most ..
  43. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ....
  44. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..Using our new Blastomyces-specific TCR Tg mouse, we have established an in vitro screen with bone marrow derived dendritic cells from knockout mice and an in vivo adoptive transfer system to delineate the signaling ..
  45. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..a method to knock down individual genes in CD4+ and CD8+ cells in humanized mice transplanted with human bone marrow, fetal liver and thymus (BLT mice) and use it to manipulate human immunity in vivo...
  46. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..Additionally it is hypothesized that a potential source of this telomerase expressing fibroblast is the bone marrow from where it is recruited by signals from the injured lung...
  47. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSC), largely residing in the bone marrow of adult mammals, are the progenitors of all blood cells, including all myeloid and lymphoid lineages...
  48. The Role of Adipocyte-Induced Inflammation in Prostate Tumor Progression
    AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012
    ..Our previous studies have shown that adipocyte maturation is severely impaired in bone marrow of CTSK deficient mice...
  49. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..current investigators have a longtime interest in how hormonal alterations in this disease lead to changes in bone marrow composition and skeletal losses...
  50. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: We are developing a new regenerative therapy for the treatment of myocardial infarction (heart attacks). A new drug will stimulate the heart to repair itself. ..
  51. PRE- AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGY
    J Evan Sadler; Fiscal Year: 2013
    ..metabolism and cell signaling pathways;mechanisms of hematopoiesis;telomerase and ribosomal protein defects in bone marrow failure syndromes;molecular basis for protein trafficking in mammalian cells;role of platelets and angiogenesis ..
  52. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..on the homeostasis of tissue resident lymphocytes by determining 1) T and B cell subset distribution in bone marrow, lymph nodes, bronchoalveolar lavage, and gut biopsies;and 2) the cytokine milieu of these tissues...
  53. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..We have demonstrated that bone marrow origin macrophages migrate to the mouse lung at the time of up regulation of endothelial cell VCAM-1 and ICAM-1 ..
  54. Role of Sex Chromosome Complement in the CNS during Autoimmune Disease
    Sienmi Du; Fiscal Year: 2013
    ..Irradiation bone marrow chimera is a widely used tool in basic immunology to manipulate the immune system independently from other ..
  55. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2013
    ..Cells of the host immune response are ultimately derived from hematopoietic stem cells (HSCs) in bone marrow. I have capitalized on the institutional strength of BCM in the field of stem cell biology to pursue ..
  56. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Preclinical studies have demonstrated that bone marrow contains cells that can engraft and become competent osteoblasts after transplantation...
  57. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..group of disorders that include primary or de novo MDS, and "secondary MDS" following congenital or acquired bone marrow failure (BMF) syndromes or cytotoxic therapy...
  58. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..A novel mouse model for conditional cell-type specific Parp1 targeting, Parp1/Rag1 double knockout mice, and bone marrow chimeras developed as part of this proposal will be used in the following specific aims: (1) we are planning to ..
  59. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..A similar defect appears to exist in humans where transplanted bone marrow (BM) stem cells from older adult human donors often fail to give rise to B cells...
  60. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..Moreover, data from bone marrow transplant experiments suggest that parenchymal expression of HO-1 is critical for the prevention of organ ..
  61. Molecular Pathogenesis of MDS and CMML
    Jaroslaw P Maciejewski; Fiscal Year: 2013
    ..In SA1 we will analyze paired samples (bone marrow and sorted CD3+ cells as a clonal control) from patients with MDS using the Affymetrix 6.0 SNP array...
  62. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..Although blood platelet numbers are therefore regulated precisely, we know little about the process by which bone marrow megakaryocytes produce and release platelets...
  63. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    ..as a transcriptional regulator by studying DlaT's expression under different conditions in vitro, in mouse bone marrow macrophages and in mice, by identifying proteins associating with DlaT under those conditions, by producing ..
  64. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..Dr. Jakub Tolar was the first to perform clinical trials using systemically delivered allogeneic bone marrow (BM)-derived cells in the treatment of RDEB patients, and for that reason, he was recruited as a PI on this ..
  65. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first ..
  66. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2013
    ..We therefore anticipate rapid translation of the optimized promising pretargeted RIT into our clinical RIT HCT program for AML and MDS. ..
  67. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
  68. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..Chimeric mice, created by adoptive transfer of green fluorescent protein positive bone marrow cells to wild type recipients, will serve to identif the recruited and resident cell populations...
  69. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..Since macrophages derived from bone marrow hematopoietic stem cells (HSC), are key to the initiation and progression of atherosclerosis, the therapeutic ..
  70. Periostin Regulation of Lung Fibrosis
    Bethany B Moore; Fiscal Year: 2013
    ..Our published results using bone marrow chimeric mice indicate that both structural and hematopoietic sources of periostin are required for development ..
  71. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..To define the role of macrophage-expressed GX sPLA2 in adipose tissue. This will be achieved by performing a bone marrow transplant experiment in which wild-type and GX KO mice will be reconstituted with bone marrow cells derived ..
  72. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2013
    ..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound ..
  73. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2013
    ..to provide the missing enzyme to myelinating glia via infiltrating macrophages after the transplantation of bone marrow cells (BMT) from healthy donors into affected patients...
  74. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..The proposed research studies will address the capacity of bone marrow-derived mesenchymal stem cells (MSC) to regenerate the oral mucosa epithelium by mimicking an environment in ..
  75. ROS, Redox Regulation and Novel Targets for Cancer Therapy
    Peng Huang; Fiscal Year: 2013
    ..We also found that that were highly dependent on the bone marrow stromal cells to alleviate the oxidative stress and promote their survival and drug resistance through ..
  76. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    ..capacity of calcineurin inhibition has been one of the greatest contributions to our current solid organ and bone marrow transplantation abilities. However, inhibition of HC causes severe immunosuppression and toxicity...
  77. Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    BENJAMIN BRAUN; Fiscal Year: 2013
    ..Pathogenic bone marrow progenitors in KrasD12 mice demonstrate: (1) biased differentiation that favors the granulocyte/macrophage (GM) ..
  78. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..analysis demonstrated osteogeneis, significant new bone formation, dense thickening of the trabeculae and bone marrow formation. Most importantly, new bone tissue was derived from the human VSELs...
  79. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..The mainstay of treatment is multi-agent chemotherapy and bone marrow transplantation, both of which have many complications and high mortality...
  80. Phase 1 Study of Quercetin for the Treatment of Fanconi Anemia
    Parinda Mehta; Fiscal Year: 2013
    Project Summary/Abstract Current therapies for children with Fanconi anemia (FA) and bone marrow failure, i.e. androgens or bone marrow transplantation, are associated with significant morbidity and mortality...
  81. Study DNA repair in preventing MDS and AML after radiation and benzene exposure
    EDWARD PAUL HASTY; Fiscal Year: 2013
    ..the role that DNA damage/repair plays in disease progression, the impact these genotoxins have on a variety of bone marrow cells including HSCs and vulnerable times of exposure (embryonic development vs. adult)...
  82. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple myeloma (MM) is a bone marrow plasma cell cancer with a mortality rate greater than 50%1...
  83. Chronic imaging of cellular dynamics after cortical microhemorrhage
    Chris B Schaffer; Fiscal Year: 2013
    ..These experiments use chimeric animals created through bone marrow transplants to achieve specific labeling of either microglia or macrophages...
  84. Validation and Development of WEE1 as a therapeutic target in AML
    Christopher C Porter; Fiscal Year: 2013
    ..to oncogenic stresses in myeloid progenitor cells and perform immunohistochemistry for Wee1 expression in AML bone marrow biopsy specimens...
  85. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..We will evaluate gain- and loss-of function model systems that promote or reduce senescent PMN clearance in the bone marrow or survival in the circulation...
  86. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..In vivo techniques of bone marrow and liver transplantation are proposed to examine cellular mechanisms of action of these MMPs...
  87. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..Megakaryocytes are hematopoietic cells found principally in the bone marrow, where they release large membrane-encapsulated cytoplasmic fragments that mature into normal platelets...
  88. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2013
    ..Transplantation of wild type bone marrow into irradiation-conditioned Mecp2-null hosts resulted in engraftment of brain parenchyma by bone marrow-..
  89. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..Using reciprocal bone marrow chimera p47phox-/- wt mice, we observed that p47phox-/- bone marrow in wt mice resulted in enhanced NF-[..
  90. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    ..team of researchers with expertise in the biology of IPF, lung vascular biology, heart failure, and bone marrow derived mesenchymal stem cell (MSC) biology at the University of Pittsburgh and established a collaboration ..
  91. Analysis of mDia formins in hematopoietic stem cell engraftment and migration
    Peng Ji; Fiscal Year: 2013
    ..HSC engraftment and migration are critical for successful bone marrow transplantation, which has become a routine clinical strategy for treating patients with many blood related ..
  92. Multifunctional nanoparticles to improve treatment of human glioblastoma
    Miqin Zhang; Fiscal Year: 2013
    ..their poor pharmacokinetics such as poor permeability of the blood-brain barrier (BBB), a short half-life, and bone marrow producing deleterious side-effects...
  93. Global Genomic and Proteomic Profiling of African Children with Typhoid Fever
    Stephen Obaro; Fiscal Year: 2013
    ..Classifier proteins obtained from our new, custom whole-proteome typhoid fever microarrays will provide new insights of targeted proteins and antibodies for next-generation vaccine development. ..
  94. Molecular Mechanisms of Host Function Exploitation by Type IV effectors of Legion
    Zhao Qing Luo; Fiscal Year: 2013
    ..First, a sidJ deletion mutant was defective in intracellular growth in both mouse bone marrow-derived macrophages and the amoebae host Dictyostelium discoideum...
  95. Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor Microenvironme
    ASISH KUMAR GHOSH; Fiscal Year: 2013
    ..that CLL MV and CLL stromal cell interaction results in robust activation of the AKT signaling pathway in CLL-bone marrow stromal cells (BMSC), leading to enhanced production of vascular endothelial growth factor (VEGF), a ..
  96. Long-acting growth factors for treating the acute and long term effects of lethal
    Christie M Orschell; Fiscal Year: 2013
    ..S. government due to the potential threat of a terrorist nuclear attack or nuclear accident. Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first ..
  97. Role of GLIS2 in the Development of Cystic Kidney Disease
    Massimo Attanasio; Fiscal Year: 2013
    ..and Myd88flox/flox;Glis2mut/mut;KspCre double mutants and establishing Tlr2-/-;Glis2mut/mut bone marrow chimeras...
  98. Beta-catenin is a molecular target of the Fanconi anemia core complex
    Kim Hien T Dao; Fiscal Year: 2013
    ..perturbations in Wnt/beta-catenin signaling in FA-deficient hematopoietic stem cells during development and bone marrow failure in an in vivo model of FA...
  99. Enhancement of Medullary Erythropoiesis during Anemia by Trib3
    David Kuhrt; Fiscal Year: 2013
    ..steady state erythropoiesis is unperturbed, but during anemia or ESA administration stress erythropoiesis in bone marrow is compromised...
  100. Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
    AMELIA RACHEL HAAS BAKER; Fiscal Year: 2013
    ..Our data indicate that TBT is a highly potent activator of PPAR( in bone marrow stromal cells...
  101. Role of EGFR signaling in bone formation and the anabolic actions of PTH
    Ling Qin; Fiscal Year: 2013
    ..how PTH exerts its beneficial effects, but whether these effects include, or are mediated by, a stimulation of bone marrow mesenchymal progenitor activities, is not clear...