bone marrow

Summary

Summary: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Top Publications

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  2. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
  3. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
  4. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
  5. ncbi Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    Teru Hideshima
    Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Nat Rev Cancer 7:585-98. 2007
  6. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
  7. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
  8. ncbi Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
  9. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010
  10. ncbi Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 7:391-402. 2010

Detail Information

Publications275 found, 100 shown here

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum...
  2. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
    ..MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling ..
  3. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
    In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear...
  4. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
    ..In mammals, the best understood niche is that harboring bone marrow hematopoietic stem cells (HSCs)...
  5. ncbi Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    Teru Hideshima
    Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Nat Rev Cancer 7:585-98. 2007
    ..The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies...
  6. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..and that although the numbers of B-cell progenitors in mutant embryos were severely reduced in fetal liver and bone marrow, myeloid progenitors were reduced only in the bone marrow but not in the fetal liver, indicating that PBSF/SDF-..
  7. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
    ..hematopoietic stem cells through the blood, across the endothelial vasculature to different organs and to their bone marrow (BM) niches, requires active navigation, a process termed homing...
  8. ncbi Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
    Mesenchymal stem cell populations have previously been identified in adult bone marrow and dental pulp that are capable of regenerating the bone marrow and dental pulp microenvironments, respectively...
  9. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010
    ..Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal ..
  10. ncbi Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 7:391-402. 2010
    ..Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM)...
  11. doi Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
    ..Here we identified NCSCs in the bone marrow (BM), dorsal root ganglia, and whisker pad and prospectively isolated them from adult transgenic mice encoding ..
  12. doi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..HSCs and their progenitors fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment...
  13. ncbi Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..diabetes, circulating EPCs were reduced to 39 +/- 5% of controls and associated with uncoupled eNOS in bone marrow. Our results identify uncoupling of eNOS in diabetic bone marrow, glucose-treated EPCs, and EPCs from diabetic ..
  14. ncbi CXCL12 and CXCR4 in bone marrow physiology
    Natalia M Moll
    CRICM INSERM UPMC, UMRS 975 CNRS UMR 7225, Faculte de Medecine Pierre et Marie Curie, Hopital Pitie Salpetriere, 105 bd de l Hopital, 75634 Paris, France
    Expert Rev Hematol 3:315-22. 2010
    This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation...
  15. doi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
    ..Contradictory results with bone marrow (BM)-derived MSCs have initiated a comprehensive comparison of HS, tPRP, and pooled human platelet lysate (pHPL)..
  16. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ..evidence that the SDF-1alpha/CXCR4 chemokine axis is involved in both the retention of neutrophils within the bone marrow and the homing of senescent neutrophils back to the bone marrow...
  17. pmc HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy
    Christine M Durand
    Department of Medicine, The Sidney Kimmel CancerCenter, USA
    J Infect Dis 205:1014-8. 2012
    ..We obtained bone marrow aspirates from 11 patients on ART who had undetectable plasma HIV-1 RNA...
  18. doi Awakening dormant haematopoietic stem cells
    Andreas Trumpp
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
    Nat Rev Immunol 10:201-9. 2010
    Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells...
  19. pmc Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
    Matthew J Christopher
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 114:1331-9. 2009
    ..cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone ..
  20. pmc CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 113:4341-51. 2009
    The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents...
  21. ncbi Adult rat and human bone marrow stromal cells differentiate into neurons
    D Woodbury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 61:364-70. 2000
    b>Bone marrow stromal cells exhibit multiple traits of a stem cell population. They can be greatly expanded in vitro and induced to differentiate into multiple mesenchymal cell types...
  22. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  23. ncbi Dynamic visualization of thrombopoiesis within bone marrow
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 317:1767-70. 2007
    Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood...
  24. doi Subsets, expansion and activation of myeloid-derived suppressor cells
    Eliana Ribechini
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, Wurzburg, Germany
    Med Microbiol Immunol 199:273-81. 2010
    ..Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites...
  25. pmc Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:590-601. 2011
    ..Monocytes originate from bone marrow and their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic ..
  26. pmc Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells
    Yong Wang
    Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA
    Free Radic Biol Med 48:348-56. 2010
    ..and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM) injury...
  27. ncbi Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    Andrea Augello
    Laboratory of Regenerative Medicine, National Institute for Cancer Research, Genova, Italy
    Eur J Immunol 35:1482-90. 2005
    b>Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation...
  28. ncbi Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family
    T J Fleming
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    J Immunol 151:2399-408. 1993
    ..FACS analysis using 1A8 demonstrated that Ly-6G was expressed in bone marrow but not substantially on other lymphoid tissues, including activated T and B cells...
  29. doi Detection of functional haematopoietic stem cell niche using real-time imaging
    Yucai Xie
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nature 457:97-101. 2009
    ..HSCs home to bone marrow through the vascular system...
  30. doi Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells
    Angela Colmone
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA
    Science 322:1861-5. 2008
    ..imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments that sequester transplanted human CD34+ (HPC-enriched) cells...
  31. doi Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
    Satoshi Yamazaki
    Japan Science and Technology Agency, ERATO, Chiyoda ku, Tokyo 102 0075, Japan
    Cell 147:1146-58. 2011
    Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial...
  32. ncbi CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
    Haematologica 93:423-30. 2008
    ..about the number and function of immunosuppressive CD4(+)CD25(+)FOXP3(+) T regulatory cells (Treg) in the human bone marrow and it is unclear whether bone marrow-residing Treg are capable of regenerating following allogeneic stem cell ..
  33. doi Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis
    Una Riekstina
    Faculty of Medicine, University of Latvia, Riga LV 1001, Latvia
    Stem Cell Rev 5:378-86. 2009
    Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues, e.g., bone marrow, adipose tissue, dermis, hair follicles, heart, liver, spleen, dental pulp...
  34. pmc Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow
    Steven G DuBois
    Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94143 0106, USA
    Pediatr Blood Cancer 54:13-8. 2010
    ..A new method for detecting circulating Ewing sarcoma cells using flow cytometry is described. This strategy exploits the nearly universal expression of CD99 and the lack of expression of CD45 by Ewing sarcoma cells...
  35. ncbi The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance
    Mark B Meads
    Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Clin Cancer Res 14:2519-26. 2008
    The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells...
  36. pmc A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    Kimberly Noonan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Blood 116:3554-63. 2010
    ..Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances ..
  37. pmc Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications
    Karina T Wright
    Spinal Studies and Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Stem Cells 29:169-78. 2011
    Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies...
  38. pmc Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:691-9. 2011
    ..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
  39. doi The bone marrow: a site of neutrophil clearance
    Sara M Rankin
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, Exhibition Rd, London, SW7 2AZ, UK
    J Leukoc Biol 88:241-51. 2010
    ..current dogma that neutrophils are cleared primarily in the liver and spleen, presenting the evidence that the bone marrow is also an important site of neutrophil clearance under homeostatic conditions...
  40. pmc Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction
    Ewa K Zuba-Surma
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    J Cell Mol Med 15:1319-28. 2011
    Adult bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) exhibit a Sca-1(+)/Lin(-)/CD45(-) phenotype and can differentiate into various cell types, including cardiomyocytes and endothelial cells...
  41. doi Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:3330-7. 2010
    The significance of circulating tumor cells (CTCs) in blood and of disseminated tumor cells (DTCs) in bone marrow (BM) in patients with early stage breast cancer is unclear...
  42. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive...
  43. ncbi Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury
    Jie Ma
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Acaademy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Haematologica 92:889-96. 2007
    ..senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchymal stem cells (MSC)...
  44. ncbi Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow
    Katia Mareschi
    Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
    J Cell Biochem 97:744-54. 2006
    ..We isolated and expanded MSCs from bone marrow (BM) of pediatric and young adult donors, to analyze the growth kinetic, immunophenotype, telomere length, ..
  45. ncbi The bone marrow vascular niche: home of HSC differentiation and mobilization
    Hans Georg Kopp
    Weill Medical College of Cornell University, New York, New York, USA
    Physiology (Bethesda) 20:349-56. 2005
    The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells...
  46. doi Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis
    Wolfgang Janni
    Frauenklinik der Heinrich Heine Universität, Dusseldorf, Germany
    Clin Cancer Res 17:2967-76. 2011
    The prognostic significance of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a large pooled analysis...
  47. ncbi Microenvironmental niches in the bone marrow required for B-cell development
    Takashi Nagasawa
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Rev Immunol 6:107-16. 2006
    ..This article summarizes the recent advances in research on the earliest B-cell precursors, their requisite environmental factors and the cellular niches that supply these factors and maintain B cells during their development...
  48. pmc Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to
    M Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 24:976-85. 2010
    ..which major chemoattractant present in peripheral blood (PB) is responsible for the egress of HSPCs from the bone marrow (BM)...
  49. pmc Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
    Sebastian Stier
    Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 201:1781-91. 2005
    ..for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment...
  50. pmc Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi
    A B Reis
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Departamento de Análises Clínicas Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil
    Clin Exp Immunol 146:303-11. 2006
    ..Herein, we have assessed the correlation between the clinical status as well as the impact of bone marrow parasite density on the phenotypic profile of peripheral blood leucocytes in 40 Brazilian dogs naturally ..
  51. pmc Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3
    I Vande Broek
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Laarbeeklaan 101, Belgium
    Br J Cancer 88:855-62. 2003
    The restricted bone marrow (BM) localisation of multiple myeloma (MM) cells most likely results from a specific homing influenced by chemotactic factors, combined with the proper signals for growth and survival provided by the BM ..
  52. ncbi Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova 15145, Italy
    Stem Cells 26:151-62. 2008
    Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating neutrophils...
  53. ncbi Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
    Fumihiko Ishikawa
    Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho Tsurumi ku, Yokohama 230 0045, Japan
    Nat Biotechnol 25:1315-21. 2007
    ..They home to and engraft within the osteoblast-rich area of the bone marrow, where AML cells are protected from chemotherapy-induced apoptosis...
  54. pmc Bone marrow microenvironment and the identification of new targets for myeloma therapy
    K Podar
    Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics, Dana Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Boston, MA 02115, USA
    Leukemia 23:10-24. 2009
    ..both early and late genetic changes in the tumor cell as well as selective supportive conditions by the bone marrow (BM) microenvironment...
  55. ncbi An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
    ..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
  56. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    ..The transgenic offspring showed an almost complete lack of bone marrow in newborns, owing to strongly retarded vascular invasion into hypertrophic cartilage and impaired cartilage ..
  57. pmc Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression
    Dingcheng Gao
    Department of Cardiothoracic Surgery, Lehman Brothers Lung Cancer Research Center, Cornell University Medical Center, New York, NY 10065, USA
    Biochim Biophys Acta 1796:33-40. 2009
    Emerging evidence indicates that bone marrow (BM)-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated growth of certain tumors in mice and human...
  58. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  59. pmc Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 457:92-6. 2009
    ..confocal microscopy and two-photon video imaging of individual haematopoietic cells in the calvarium bone marrow of living mice over time, we examine the relationship of haematopoietic stem and progenitor cells to blood ..
  60. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
    B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not...
  61. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals...
  62. ncbi Thymic and bone marrow output in patients with common variable immunodeficiency
    Federico Serana
    Department of Biomedical Science and Biotechnology, University of Brescia, Brescia, Italy
    J Clin Immunol 31:540-9. 2011
    ..The study aims to obtain more information about the immune deficit of common variable immunodeficiency (CVID) patients...
  63. doi Bone marrow-derived mesenchymal stem cells enhanced diabetic wound healing through recruitment of tissue regeneration in a rat model of streptozotocin-induced diabetes
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Plast Reconstr Surg 128:872-80. 2011
    This study investigated whether bone marrow-derived mesenchymal stem cell therapy has effectiveness in the enhancement of diabetic wound healing through tissue regeneration.
  64. ncbi Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    Scott T Avecilla
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 10:64-71. 2004
    ..Here we report that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production...
  65. pmc The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse
    Rebecca C Furze
    Leukocyte Biology Section, Sir Alexander Fleming Building, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK SW7 2AZ
    FASEB J 22:3111-9. 2008
    In humans, 10(11) neutrophils are released from the bone marrow per day, and these cells have a half-life in the blood of only approximately 6.5 h...
  66. doi Eosinophils are required for the maintenance of plasma cells in the bone marrow
    Van Trung Chu
    Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
    Nat Immunol 12:151-9. 2011
    ..It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key ..
  67. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..plasma cells are nonrecirculatory and lodge in splenic red pulp, lymph node medullary cords, and bone marrow. The factors that regulate plasma cell localization are poorly defined...
  68. ncbi Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations
    Shuei Liong Lin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:6733-43. 2009
    ..three distinct subpopulations defined by the marker Ly6C, all of which are derived from a single Ly6C(high) bone marrow monocyte population selectively recruited to the kidney...
  69. pmc Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
    Nadine N Bewry
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33613, USA
    Mol Cancer Ther 7:3169-75. 2008
    ..The bone marrow is the predominant microenvironment of CML and is a rich source of both soluble factors and extracellular ..
  70. pmc Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer
    A Daskalaki
    Department of Pathology, University General Hospital of Heraklion, Crete 71110, Greece
    Br J Cancer 101:589-97. 2009
    ..rates and evaluate the clinical relevance of cytokeratin-19 (CK-19) mRNA-positive cells in the peripheral blood (circulating tumour cells, CTCs) and bone marrow (disseminated tumour cells; DTCs) of patients with early breast cancer.
  71. doi Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)
    I Kotsianidis
    Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Leukemia 23:510-8. 2009
    ..MDS), immune deregulation and autoimmunity in the early stages might lead to ineffective hematopoiesis and bone marrow (BM) failure, whereas late-stage disease is characterized by the immune escape of the malignant clone...
  72. ncbi The relationship between bone, hemopoietic stem cells, and vasculature
    Sarah L Ellis
    Peter MacCallum Cancer Centre, Melbourne, Australia
    Blood 118:1516-24. 2011
    ....
  73. doi Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern
    Katharina E Effenberger
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Breast Cancer Res Treat 125:729-38. 2011
    ..Using these antibodies bone marrow aspirates from 391 breast cancer patients (M(0), pT1-3, pN0-3) were screened for the presence of DTC...
  74. pmc Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
    Brahmananda R Chitteti
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 115:3239-48. 2010
    ..These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs...
  75. ncbi Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation
    James F Griffith
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, Hong Kong SAR, China
    Radiology 241:831-8. 2006
    ..To prospectively study the relationship among vertebral marrow fat content, marrow diffusion indexes, and marrow and erector spinae muscle perfusion indexes in female subjects with varying bone mineral density...
  76. doi Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue
    Linyi Peng
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Stem Cells Dev 17:761-73. 2008
    Mesenchymal stem cells (MSCs) isolated from bone marrow (BM), cartilage, and adipose tissue (AT) possess the capacity for self-renewal and the potential for multilineage differentiation, and are therefore perceived as attractive sources ..
  77. pmc Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    Claire M Edwards
    Department of Cancer Biology, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN 37232, USA
    Blood 111:2833-42. 2008
    ..In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in myeloma counteracts development of osteolytic bone disease...
  78. ncbi Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells
    Takafumi Yokota
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73190 3048, USA
    Stem Cells 24:13-22. 2006
    ..alpha-actin (alphaSMA) promoter-driven green fluorescent protein (GFP) transgenic mice (alphaSMA-GFP mice) for bone marrow transplantation to evaluate their potential to generate donor-type tissues in irradiation chimeras...
  79. ncbi Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout mice
    Stéphane Potteaux
    Institut National de la Sante et de la Recherche Medicale, INSERM U689, Centre de Recherché Cardiovasculaire Lariboisière, Paris, France
    Arterioscler Thromb Vasc Biol 26:1858-63. 2006
    ..We examined the role of bone marrow-derived CCR5 in the development of atherosclerotic lesions after 8, 12, or 35 weeks of high-fat diet.
  80. ncbi Review: Biological relevance of disseminated tumor cells in cancer patients
    Sabine Riethdorf
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:1991-2006. 2008
    ..assays enable the detection and characterization of disseminated tumor cells (DTC) at the single cell level in bone marrow (BM) as the common homing site of DTC and circulating tumor cells (CTC) in peripheral blood...
  81. ncbi Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Cell 135:1118-29. 2008
    b>Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells...
  82. ncbi Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 70:50-60. 2006
    ..However, potential underlying mechanisms have not yet been investigated...
  83. ncbi Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients
    Kjersti Flatmark
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Clin Cancer Res 8:444-9. 2002
    Detection of micrometastatic cells in bone marrow (BM) may potentially be of prognostic value in colorectal cancer (CRC)...
  84. ncbi Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
    N D Theise
    Department of Pathology, New York University, School of Medicine, New York, NY 10016, USA
    Hepatology 31:235-40. 2000
    Following a report of skeletal muscle regeneration from bone marrow cells, we investigated whether hepatocytes could also derive in vivo from bone marrow cells...
  85. ncbi A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamers
    Ke Tai Guo
    Department of Thoracic, Cardiac, and Vascular Surgery, University Hospital of Tuebingen, Germany
    Stem Cells 24:2220-31. 2006
    Adult mesenchymal stem cells (aMSCs) are a stem cell population present in bone marrow, which can be isolated and expanded in culture and characterized...
  86. pmc G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Craig L Semerad
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
    Blood 106:3020-7. 2005
    ..CXC motif, receptor 4), generates signals that regulate hematopoietic progenitor cell (HPC) trafficking in the bone marrow. During granulocyte colony-stimulating factor (G-CSF)-induced HPC mobilization, CXCL12 protein expression in ..
  87. pmc Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    Tanja Fehm
    Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
    Breast Cancer Res 11:R59. 2009
    ..of CTCs in blood, we evaluated the correlation between CTCs and disseminated tumor cells (DTCs) in the bone marrow (BM), and we characterized CTCs for the expression of HER2, the estrogen receptor (ER) and the progesterone ..
  88. doi Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization
    Sang Mo Kwon
    Stem Cell Translational Research Laboratory, RIKEN Center For Developmental Biology Institute of Biomedical Research and Innovation, Kobe, Japan
    Circulation 118:157-65. 2008
    ..Despite accumulating evidence that proves the pivotal role of endothelial progenitor cells (EPCs) in ischemic neovascularization, the key signaling cascade that regulates functional EPC kinetics remains unclear...
  89. doi MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathway
    J Li
    State Key Laboratory of Oral Diseases, West China College of Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    Cell Prolif 43:333-43. 2010
    ..study was carried out to reveal functions and mechanisms of MEK/ERK and p38 pathways in chondrogenesis of rat bone marrow mesenchymal stem cells (BMSCs), and to investigate further any interactions between the mitogen-activated ..
  90. pmc On the adaptation of endosteal stem cell niche function in response to stress
    Yi Jiang
    University of Washington, Department of Medicine Hematology, Seattle, WA 98195, USA
    Blood 114:3773-82. 2009
    ..A similar phenotype was observed with cells rendered G(i)-protein signaling incompetent by pertussis toxin treatment, supporting an active stromal-derived factor 1 (SDF-1) gradient near endosteum after irradiation...
  91. doi Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse
    Osamu Imataki
    Division of Hematology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Int J Clin Oncol 15:112-5. 2010
    ..Although her bone marrow achieved remission after induction therapy, there was a small residual population of leukemic cells in the ..
  92. ncbi Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide
    Lee J Goldstein
    Department of Surgery, University of Pennsylvania Medical Center, 4th Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, Pennsylvania 19124, USA
    Stem Cells 24:2309-18. 2006
    ..to be regulated by hypoxic gradients and induced by vascular endothelial growth factor-mediated increases in bone marrow nitric oxide (NO)...
  93. doi Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α
    Yehuda Kamari
    The Bert Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel
    Biochem Biophys Res Commun 405:197-203. 2011
    ..We assessed whether IL-1α and IL-1β from tissue resident vascular cells or emigrating bone marrow-derived cells promote the development of atherosclerosis in apoE-/- mice and determined the effect of selective ..
  94. pmc Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis
    Mattias Fransson
    Laboratory of Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Respir Res 8:17. 2007
    Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood...
  95. doi The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients
    Yanran Cao
    Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 38:860-7. 2010
    The interaction of multiple myeloma (MM) with its bone marrow (BM) microenvironment is important for the homing pattern, survival, and proliferation of malignant plasma cells...
  96. pmc Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells
    Ryo Suzuki
    National Institutes of Health, Bethesda, MD 20892 1930, USA
    J Leukoc Biol 88:863-75. 2010
    ..This demonstrates that in addition to a role described previously for Orai1 in promoting MC degranulation, nonselective cation channels participate in promoting the exocytotic response...
  97. doi Nanobodies as tools for in vivo imaging of specific immune cell types
    Kurt De Groeve
    Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    J Nucl Med 51:782-9. 2010
    ..In the present study, we have evaluated the use of Nanobodies as a generic method for imaging the in vivo biodistribution of specific immune cell types, using myeloid cells as an example...
  98. doi HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer
    Julie E Lang
    Department of Surgical Oncology, MD Anderson Cancer Center, Advanced Research Center for Microscopic Disease, The University of Texas, Houston, TX 77030, USA
    Breast Cancer Res Treat 113:501-7. 2009
    ..We hypothesized that primary tumor characteristics would predict the likelihood of identifying CTCs in patients with operable breast cancer...
  99. pmc Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections
    Alexander A Navarini
    Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:7107-12. 2009
    ..These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils are ..
  100. pmc CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
    Yu Tzu Tai
    LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 113:4309-18. 2009
    ..CS1 overexpression promoted myeloma cell growth and survival by significantly increasing myeloma adhesion to bone marrow stromal cells (BMSCs) and enhancing myeloma colony formation in semisolid culture...
  101. pmc Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow
    Pratibha Singh
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Stem Cells 26:1009-16. 2008
    Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved in the immune response...

Research Grants141 found, 100 shown here

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow. The recipient's bone marrow can then produce new blood cells...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow. The recipient's bone marrow can then produce new blood cells...
  3. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2013
    ..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
  4. Biochemistry and Molecular Biology Core
    Asish Saha; Fiscal Year: 2009
    ..3%) subpopulation of bone marrow cells that are positive for the transgene (1)...
  5. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    ..B19V replication is highly restricted to human erythroid progenitor cells (EPCs) in the bone marrow and fetal liver...
  6. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..We found a Gas2-dependent decrease in calpain activity and increase in bcatenin in Bcr-abl+ or Icsbp-/- murine bone marrow cells. Stat3, Stat5 and Xiap proteins are also increased in Icsbp-/- cells in a Gas2/calpain-dependent manner...
  7. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..on PGE2-mediated HSC growth and proliferation will enable targeted therapeutic approaches for the treatment of bone marrow failure states, recovery from chemotherapy, or after HSC transplant...
  8. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..b>Bone marrow mesenchymal stem cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone ..
  9. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..Arg2-/-iNOS-/- double knockout mice that will be compared to wild-type (WT), Arg2-/-, and iNOS-/- mice, and bone marrow chimeras will be used, to examine A) H...
  10. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2011
    ..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
  11. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2010
    ..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
  12. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2009
    ..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
  13. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2012
    ..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
  14. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSC), largely residing in the bone marrow of adult mammals, are the progenitors of all blood cells, including all myeloid and lymphoid lineages...
  15. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..on the homeostasis of tissue resident lymphocytes by determining 1) T and B cell subset distribution in bone marrow, lymph nodes, bronchoalveolar lavage, and gut biopsies;and 2) the cytokine milieu of these tissues...
  16. Role of Sex Chromosome Complement in the CNS during Autoimmune Disease
    Sienmi Du; Fiscal Year: 2013
    ..Irradiation bone marrow chimera is a widely used tool in basic immunology to manipulate the immune system independently from other ..
  17. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..A novel mouse model for conditional cell-type specific Parp1 targeting, Parp1/Rag1 double knockout mice, and bone marrow chimeras developed as part of this proposal will be used in the following specific aims: (1) we are planning to ..
  18. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..Dr. Jakub Tolar was the first to perform clinical trials using systemically delivered allogeneic bone marrow (BM)-derived cells in the treatment of RDEB patients, and for that reason, he was recruited as a PI on this ..
  19. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..GSK-3 during pressure overload-induced cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on novel connections between GSK-3 isoforms and their ..
  20. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first ..
  21. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2013
    ..We therefore anticipate rapid translation of the optimized promising pretargeted RIT into our clinical RIT HCT program for AML and MDS. ..
  22. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
  23. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..Chimeric mice, created by adoptive transfer of green fluorescent protein positive bone marrow cells to wild type recipients, will serve to identif the recruited and resident cell populations...
  24. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..Since macrophages derived from bone marrow hematopoietic stem cells (HSC), are key to the initiation and progression of atherosclerosis, the therapeutic ..
  25. Periostin Regulation of Lung Fibrosis
    Bethany B Moore; Fiscal Year: 2013
    ..Our published results using bone marrow chimeric mice indicate that both structural and hematopoietic sources of periostin are required for development ..
  26. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2013
    ..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound ..
  27. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
    ..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound ..
  28. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..To define the role of macrophage-expressed GX sPLA2 in adipose tissue. This will be achieved by performing a bone marrow transplant experiment in which wild-type and GX KO mice will be reconstituted with bone marrow cells derived ..
  29. Characterization of Genetic Abnormalities in MDS and Their Clinical Impact
    Rafael Bejar; Fiscal Year: 2012
    ..The specific aims of this proposal are to: (1) study a clinically annotated cohort of 439 bone marrow samples from patients with MDS to determine if the mutations they carry are associated with common clinical ..
  30. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..IL-7 plays a critical role in regulation of EBF expression at an early phase of B cell development in adult bone marrow. Dysfunction of IL-7 receptor subunits (either 11-7 receptor alpha or common gamma chains) causes profound ..
  31. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2013
    ..to provide the missing enzyme to myelinating glia via infiltrating macrophages after the transplantation of bone marrow cells (BMT) from healthy donors into affected patients...
  32. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..The proposed research studies will address the capacity of bone marrow-derived mesenchymal stem cells (MSC) to regenerate the oral mucosa epithelium by mimicking an environment in ..
  33. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    ..capacity of calcineurin inhibition has been one of the greatest contributions to our current solid organ and bone marrow transplantation abilities. However, inhibition of HC causes severe immunosuppression and toxicity...
  34. ROS, Redox Regulation and Novel Targets for Cancer Therapy
    Peng Huang; Fiscal Year: 2013
    ..We also found that that were highly dependent on the bone marrow stromal cells to alleviate the oxidative stress and promote their survival and drug resistance through ..
  35. Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    BENJAMIN BRAUN; Fiscal Year: 2013
    ..Pathogenic bone marrow progenitors in KrasD12 mice demonstrate: (1) biased differentiation that favors the granulocyte/macrophage (GM) ..
  36. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..analysis demonstrated osteogeneis, significant new bone formation, dense thickening of the trabeculae and bone marrow formation. Most importantly, new bone tissue was derived from the human VSELs...
  37. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..The mainstay of treatment is multi-agent chemotherapy and bone marrow transplantation, both of which have many complications and high mortality...
  38. Phase 1 Study of Quercetin for the Treatment of Fanconi Anemia
    Parinda Mehta; Fiscal Year: 2013
    Project Summary/Abstract Current therapies for children with Fanconi anemia (FA) and bone marrow failure, i.e. androgens or bone marrow transplantation, are associated with significant morbidity and mortality...
  39. Study DNA repair in preventing MDS and AML after radiation and benzene exposure
    EDWARD PAUL HASTY; Fiscal Year: 2013
    ..the role that DNA damage/repair plays in disease progression, the impact these genotoxins have on a variety of bone marrow cells including HSCs and vulnerable times of exposure (embryonic development vs. adult)...
  40. Validation and Development of WEE1 as a therapeutic target in AML
    Christopher C Porter; Fiscal Year: 2013
    ..to oncogenic stresses in myeloid progenitor cells and perform immunohistochemistry for Wee1 expression in AML bone marrow biopsy specimens...
  41. Chronic imaging of cellular dynamics after cortical microhemorrhage
    Chris B Schaffer; Fiscal Year: 2013
    ..These experiments use chimeric animals created through bone marrow transplants to achieve specific labeling of either microglia or macrophages...
  42. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple myeloma (MM) is a bone marrow plasma cell cancer with a mortality rate greater than 50%1...
  43. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..We will evaluate gain- and loss-of function model systems that promote or reduce senescent PMN clearance in the bone marrow or survival in the circulation...
  44. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..In vivo techniques of bone marrow and liver transplantation are proposed to examine cellular mechanisms of action of these MMPs...
  45. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..Megakaryocytes are hematopoietic cells found principally in the bone marrow, where they release large membrane-encapsulated cytoplasmic fragments that mature into normal platelets...
  46. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2013
    ..Transplantation of wild type bone marrow into irradiation-conditioned Mecp2-null hosts resulted in engraftment of brain parenchyma by bone marrow-..
  47. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
  48. GENETIC ANALYSIS OF POLARITY
    Ruth Steward; Fiscal Year: 2009
    ..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
  49. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..Using reciprocal bone marrow chimera p47phox-/- wt mice, we observed that p47phox-/- bone marrow in wt mice resulted in enhanced NF-[..
  50. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    ..team of researchers with expertise in the biology of IPF, lung vascular biology, heart failure, and bone marrow derived mesenchymal stem cell (MSC) biology at the University of Pittsburgh and established a collaboration ..
  51. Analysis of mDia formins in hematopoietic stem cell engraftment and migration
    Peng Ji; Fiscal Year: 2013
    ..HSC engraftment and migration are critical for successful bone marrow transplantation, which has become a routine clinical strategy for treating patients with many blood related ..
  52. Multifunctional nanoparticles to improve treatment of human glioblastoma
    Miqin Zhang; Fiscal Year: 2013
    ..their poor pharmacokinetics such as poor permeability of the blood-brain barrier (BBB), a short half-life, and bone marrow producing deleterious side-effects...
  53. Global Genomic and Proteomic Profiling of African Children with Typhoid Fever
    Stephen Obaro; Fiscal Year: 2013
    ..Classifier proteins obtained from our new, custom whole-proteome typhoid fever microarrays will provide new insights of targeted proteins and antibodies for next-generation vaccine development. ..
  54. Molecular Mechanisms of Host Function Exploitation by Type IV effectors of Legion
    Zhao Qing Luo; Fiscal Year: 2013
    ..First, a sidJ deletion mutant was defective in intracellular growth in both mouse bone marrow-derived macrophages and the amoebae host Dictyostelium discoideum...
  55. Long-acting growth factors for treating the acute and long term effects of lethal
    Christie M Orschell; Fiscal Year: 2013
    ..S. government due to the potential threat of a terrorist nuclear attack or nuclear accident. Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first ..
  56. Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor Microenvironme
    ASISH KUMAR GHOSH; Fiscal Year: 2013
    ..that CLL MV and CLL stromal cell interaction results in robust activation of the AKT signaling pathway in CLL-bone marrow stromal cells (BMSC), leading to enhanced production of vascular endothelial growth factor (VEGF), a ..
  57. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2012
    When successful, bone marrow transplantation (BMT) is a cure for non-malignant hematological disorders, including: sickle cell disease, aplastic anemia, thalassemia major, Diamond-Blackfan Anemia and Fanconi Anemia...
  58. Role of GLIS2 in the Development of Cystic Kidney Disease
    Massimo Attanasio; Fiscal Year: 2013
    ..and Myd88flox/flox;Glis2mut/mut;KspCre double mutants and establishing Tlr2-/-;Glis2mut/mut bone marrow chimeras...
  59. Beta-catenin is a molecular target of the Fanconi anemia core complex
    Kim Hien T Dao; Fiscal Year: 2013
    ..perturbations in Wnt/beta-catenin signaling in FA-deficient hematopoietic stem cells during development and bone marrow failure in an in vivo model of FA...
  60. Enhancement of Medullary Erythropoiesis during Anemia by Trib3
    David Kuhrt; Fiscal Year: 2013
    ..steady state erythropoiesis is unperturbed, but during anemia or ESA administration stress erythropoiesis in bone marrow is compromised...
  61. Role of EGFR signaling in bone formation and the anabolic actions of PTH
    Ling Qin; Fiscal Year: 2013
    ..how PTH exerts its beneficial effects, but whether these effects include, or are mediated by, a stimulation of bone marrow mesenchymal progenitor activities, is not clear...
  62. Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
    AMELIA RACHEL HAAS BAKER; Fiscal Year: 2013
    ..Our data indicate that TBT is a highly potent activator of PPAR( in bone marrow stromal cells...
  63. Suppression of established IgE-mediated disease
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2013
    ..First, we will test the hypothesis that effects of the cytokines IL-4 and IL-13 on non-bone marrow derived cells, such as vascular endothelial cells, smooth muscle cells, and intestinal epithelial cells, are ..
  64. Stem Cell Therapies for Primary Immune Deficiency
    Gay Crooks; Fiscal Year: 2009
    ..is to delineate the role of the thymic vascular niche in the regulation of homing to the neonatal thymus after bone marrow transplantation (BMT)...
  65. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling Burnette; Fiscal Year: 2009
    ..Several syndromes of T cell-mediated bone marrow failure have similar pathology including aplastic anemia (AA), paroxysmal nocturnal hemaglobinuria (PNH), and a ..
  66. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..murine and human hematopoietic stem cells (HSC and EPCs ) accelerates key functions of these cells including 1) bone marrow engraftment, 2) reducing the number of HSC needed for long-term reconstitution, 3) increasing CXCR-4 expression ..
  67. DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY SUSCEPTIBILITY EFFECTS IN MRI
    Nir Barzilai; Fiscal Year: 1999
    ..The change in oxygen saturation in sickle cell patients in brain and bone marrow was investigated while the patient was breathing room air or high oxygen through a face mask and comparing the ..
  68. BONE MARROW TRANSPLANTION AND ATHEROSCLEROSIS
    MacRae Linton; Fiscal Year: 1999
    ..The goal of this project is to use murine bone marrow transplantation as a method to investigate the role of the macrophage in atherosclerosis and lipoprotein ..
  69. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2010
    ..Several studies have shown that bone marrow cells can differentiate into hepatocytes, and we have also shown that bone marrow (BM) cells are able to ..
  70. Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
    AMELIA R HAAS; Fiscal Year: 2010
    ..Our data indicate that TBT is a highly potent activator of PPAR( in bone marrow stromal cells...
  71. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2000
    ..b>Bone marrow hypoproliferation (ineffective hematopoiesis) is likely to be a main contributor to the etiology of these ..
  72. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2010
    ..Cells of the host immune response are ultimately derived from hematopoietic stem cells (HSCs) in bone marrow. I have capitalized on the institutional strength of BCM in the field of stem cell biology to pursue ..
  73. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2010
    ..therapeutic strategy for which the virus is uniquely well-suited: ex vivo purging of cancer cells within human bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell ..
  74. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2012
    ..Transplantation of wild type bone marrow into irradiation-conditioned Mecp2-null hosts resulted in engraftment of brain parenchyma by bone marrow-..
  75. Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
    Juan Sanchez Ramos; Fiscal Year: 2009
    ..responsible for the decrease in beta-amyloid (A-2) deposition will be tested in a chimeric tg AD mouse in which bone marrow derived cells express green fluorescent protein (GFP)...
  76. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2010
    ..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
  77. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2009
    ..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
  78. CYCLIC ORAL ADMINISTRATION OF SCH66336 IN PATIENTS W/ ADVANCED CANCER
    A Adjei; Fiscal Year: 1999
    ..when administered orally twice daily for 7 out of 21 days in patients with advanced cancer who have no known bone marrow involvement by cancer, 2) to characterize the single- and multiple-dose pharmacokinetics of SCH 66336 following ..
  79. Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environm
    Hector L Aguila; Fiscal Year: 2010
    ..b>Bone marrow and Hematopoietic Stem Cell (HSC) transplantation are the best proof of concept on the feasibility of ..
  80. GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLS
    ROBERT BRESSLER; Fiscal Year: 1990
    ..caused the growth of large numbers of histaminecontaining, toluidine blue positive, granulated cells (HCGC) in bone marrow cultures...
  81. Pathogenesis of Chronic Wasting Disease in Transgenic Mice
    DAVIS MARTIN SEELIG; Fiscal Year: 2010
    ..murine model of chronic wasting disease (CWD) to addresses sequential prion pathogenesis and the role of bone marrow in prion trafficking and neuroinvasion...
  82. CELL AND GENE THERAPY IN A MOUSE MODEL OF HUMAN OSTEOGEN
    Christopher Niyibizi; Fiscal Year: 2000
    ..III that has defective synthesis of proalpha2(I) chains to evaluate the feasibility of reversing OI defects by bone marrow stromal cell transplantation or by use of bone marrow stromal cells to deliver therapeutic genes to bone...
  83. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2001
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  84. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2002
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  85. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 1999
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  86. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2000
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  87. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2003
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  88. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired bone marrow hematopoiesis is one of the ..
  89. GM-CSF analogs for treating acute radiation syndrome
    George Cox; Fiscal Year: 2009
    ..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired bone marrow hematopoiesis is one of the ..
  90. Novel therapies for Fanconi anemia
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a rare recessive syndrome characterized by bone marrow failure, congenital anomalies and a predisposition to malignancy...
  91. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2012
    ..current investigators have a longtime interest in how hormonal alterations in this disease lead to changes in bone marrow composition and skeletal losses...
  92. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2002
    ..neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  93. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  94. PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESIS
    ELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2000
    Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
  95. PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESIS
    ELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2001
    Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
  96. PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESIS
    ELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 1999
    Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
  97. PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESIS
    ELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2002
    Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
  98. ESTABLISHMENT OF RHESUS BONE MARROW CHIMERAS
    M Rosenzweig; Fiscal Year: 2000
    ..of life, we have demonstrated persistent chimerism of human hematopoietic cells Chimerism is highest in the bone marrow (5-10% of CD34+ cells are of human phenotype) Chimerism in the peripheral blood varies between mononuclear ..