bone marrow

Summary

Summary: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Top Publications

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  2. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
  3. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
  4. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
  5. ncbi Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    Teru Hideshima
    Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Nat Rev Cancer 7:585-98. 2007
  6. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
  7. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
  8. ncbi Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
  9. doi Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
  10. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010

Research Grants

  1. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
  2. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
  3. GENETIC ANALYSIS OF POLARITY
    Ruth Steward; Fiscal Year: 2009
  4. DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY SUSCEPTIBILITY EFFECTS IN MRI
    Nir Barzilai; Fiscal Year: 1999
  5. BONE MARROW TRANSPLANTION AND ATHEROSCLEROSIS
    MacRae Linton; Fiscal Year: 1999
  6. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2010
  7. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2010
  8. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2009
  9. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2010
  10. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2003

Detail Information

Publications273 found, 100 shown here

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum...
  2. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
    ..MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling ..
  3. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
    In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear...
  4. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
    ..In mammals, the best understood niche is that harboring bone marrow hematopoietic stem cells (HSCs)...
  5. ncbi Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    Teru Hideshima
    Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Nat Rev Cancer 7:585-98. 2007
    ..The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies...
  6. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..and that although the numbers of B-cell progenitors in mutant embryos were severely reduced in fetal liver and bone marrow, myeloid progenitors were reduced only in the bone marrow but not in the fetal liver, indicating that PBSF/SDF-..
  7. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
    ..hematopoietic stem cells through the blood, across the endothelial vasculature to different organs and to their bone marrow (BM) niches, requires active navigation, a process termed homing...
  8. ncbi Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
    Mesenchymal stem cell populations have previously been identified in adult bone marrow and dental pulp that are capable of regenerating the bone marrow and dental pulp microenvironments, respectively...
  9. doi Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
    ..Here we identified NCSCs in the bone marrow (BM), dorsal root ganglia, and whisker pad and prospectively isolated them from adult transgenic mice encoding ..
  10. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010
    ..Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal ..
  11. doi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..HSCs and their progenitors fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment...
  12. ncbi Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..diabetes, circulating EPCs were reduced to 39 +/- 5% of controls and associated with uncoupled eNOS in bone marrow. Our results identify uncoupling of eNOS in diabetic bone marrow, glucose-treated EPCs, and EPCs from diabetic ..
  13. doi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
    ..Contradictory results with bone marrow (BM)-derived MSCs have initiated a comprehensive comparison of HS, tPRP, and pooled human platelet lysate (pHPL)..
  14. doi CXCL12 and CXCR4 in bone marrow physiology
    Natalia M Moll
    CRICM INSERM UPMC, UMRS 975 CNRS UMR 7225, Faculte de Medecine Pierre et Marie Curie, Hopital Pitie Salpetriere, 105 bd de l Hopital, 75634 Paris, France
    Expert Rev Hematol 3:315-22. 2010
    This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation...
  15. pmc HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy
    Christine M Durand
    Department of Medicine, The Sidney Kimmel CancerCenter, USA
    J Infect Dis 205:1014-8. 2012
    ..We obtained bone marrow aspirates from 11 patients on ART who had undetectable plasma HIV-1 RNA...
  16. ncbi Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence
    Coralie Martin
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Immunity 19:583-93. 2003
    ..evidence that the SDF-1alpha/CXCR4 chemokine axis is involved in both the retention of neutrophils within the bone marrow and the homing of senescent neutrophils back to the bone marrow...
  17. doi Awakening dormant haematopoietic stem cells
    Andreas Trumpp
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
    Nat Rev Immunol 10:201-9. 2010
    Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells...
  18. pmc Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
    Matthew J Christopher
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 114:1331-9. 2009
    ..cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone ..
  19. ncbi Dynamic visualization of thrombopoiesis within bone marrow
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 317:1767-70. 2007
    Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood...
  20. pmc CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 113:4341-51. 2009
    The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents...
  21. ncbi Adult rat and human bone marrow stromal cells differentiate into neurons
    D Woodbury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 61:364-70. 2000
    b>Bone marrow stromal cells exhibit multiple traits of a stem cell population. They can be greatly expanded in vitro and induced to differentiate into multiple mesenchymal cell types...
  22. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  23. doi Subsets, expansion and activation of myeloid-derived suppressor cells
    Eliana Ribechini
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, Wurzburg, Germany
    Med Microbiol Immunol 199:273-81. 2010
    ..Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites...
  24. ncbi Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family
    T J Fleming
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    J Immunol 151:2399-408. 1993
    ..FACS analysis using 1A8 demonstrated that Ly-6G was expressed in bone marrow but not substantially on other lymphoid tissues, including activated T and B cells...
  25. pmc Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells
    Yong Wang
    Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA
    Free Radic Biol Med 48:348-56. 2010
    ..and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM) injury...
  26. pmc Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands
    Chao Shi
    Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:590-601. 2011
    ..Monocytes originate from bone marrow and their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic ..
  27. ncbi Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    Andrea Augello
    Laboratory of Regenerative Medicine, National Institute for Cancer Research, Genova, Italy
    Eur J Immunol 35:1482-90. 2005
    b>Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation...
  28. doi Detection of functional haematopoietic stem cell niche using real-time imaging
    Yucai Xie
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nature 457:97-101. 2009
    ..HSCs home to bone marrow through the vascular system...
  29. doi CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
    Haematologica 93:423-30. 2008
    ..about the number and function of immunosuppressive CD4(+)CD25(+)FOXP3(+) T regulatory cells (Treg) in the human bone marrow and it is unclear whether bone marrow-residing Treg are capable of regenerating following allogeneic stem cell ..
  30. pmc Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow
    Steven G DuBois
    Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94143 0106, USA
    Pediatr Blood Cancer 54:13-8. 2010
    ..A new method for detecting circulating Ewing sarcoma cells using flow cytometry is described. This strategy exploits the nearly universal expression of CD99 and the lack of expression of CD45 by Ewing sarcoma cells...
  31. doi Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis
    Una Riekstina
    Faculty of Medicine, University of Latvia, Riga LV 1001, Latvia
    Stem Cell Rev 5:378-86. 2009
    Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues, e.g., bone marrow, adipose tissue, dermis, hair follicles, heart, liver, spleen, dental pulp...
  32. doi Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells
    Angela Colmone
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA
    Science 322:1861-5. 2008
    ..imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments that sequester transplanted human CD34+ (HPC-enriched) cells...
  33. doi The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance
    Mark B Meads
    Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Clin Cancer Res 14:2519-26. 2008
    The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells...
  34. doi A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    Kimberly Noonan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Blood 116:3554-63. 2010
    ..Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances ..
  35. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive...
  36. doi Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
    Satoshi Yamazaki
    Japan Science and Technology Agency, ERATO, Chiyoda ku, Tokyo 102 0075, Japan
    Cell 147:1146-58. 2011
    Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial...
  37. pmc Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:691-9. 2011
    ..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
  38. pmc Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications
    Karina T Wright
    Spinal Studies and Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Stem Cells 29:169-78. 2011
    Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies...
  39. pmc Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction
    Ewa K Zuba-Surma
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    J Cell Mol Med 15:1319-28. 2011
    Adult bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) exhibit a Sca-1(+)/Lin(-)/CD45(-) phenotype and can differentiate into various cell types, including cardiomyocytes and endothelial cells...
  40. doi The bone marrow: a site of neutrophil clearance
    Sara M Rankin
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, Exhibition Rd, London, SW7 2AZ, UK
    J Leukoc Biol 88:241-51. 2010
    ..current dogma that neutrophils are cleared primarily in the liver and spleen, presenting the evidence that the bone marrow is also an important site of neutrophil clearance under homeostatic conditions...
  41. doi Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:3330-7. 2010
    The significance of circulating tumor cells (CTCs) in blood and of disseminated tumor cells (DTCs) in bone marrow (BM) in patients with early stage breast cancer is unclear...
  42. ncbi Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury
    Jie Ma
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Acaademy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Haematologica 92:889-96. 2007
    ..senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchymal stem cells (MSC)...
  43. ncbi Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova 15145, Italy
    Stem Cells 26:151-62. 2008
    Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating neutrophils...
  44. ncbi Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow
    Katia Mareschi
    Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
    J Cell Biochem 97:744-54. 2006
    ..We isolated and expanded MSCs from bone marrow (BM) of pediatric and young adult donors, to analyze the growth kinetic, immunophenotype, telomere length, ..
  45. ncbi The bone marrow vascular niche: home of HSC differentiation and mobilization
    Hans Georg Kopp
    Weill Medical College of Cornell University, New York, New York, USA
    Physiology (Bethesda) 20:349-56. 2005
    The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells...
  46. pmc Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
    Sebastian Stier
    Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 201:1781-91. 2005
    ..for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment...
  47. ncbi Microenvironmental niches in the bone marrow required for B-cell development
    Takashi Nagasawa
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Rev Immunol 6:107-16. 2006
    ..This article summarizes the recent advances in research on the earliest B-cell precursors, their requisite environmental factors and the cellular niches that supply these factors and maintain B cells during their development...
  48. doi Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis
    Wolfgang Janni
    Frauenklinik der Heinrich Heine Universität, Dusseldorf, Germany
    Clin Cancer Res 17:2967-76. 2011
    The prognostic significance of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a large pooled analysis...
  49. pmc Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to
    M Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 24:976-85. 2010
    ..which major chemoattractant present in peripheral blood (PB) is responsible for the egress of HSPCs from the bone marrow (BM)...
  50. pmc Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi
    A B Reis
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Departamento de Análises Clínicas Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil
    Clin Exp Immunol 146:303-11. 2006
    ..Herein, we have assessed the correlation between the clinical status as well as the impact of bone marrow parasite density on the phenotypic profile of peripheral blood leucocytes in 40 Brazilian dogs naturally ..
  51. pmc Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3
    I Vande Broek
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Laarbeeklaan 101, Belgium
    Br J Cancer 88:855-62. 2003
    The restricted bone marrow (BM) localisation of multiple myeloma (MM) cells most likely results from a specific homing influenced by chemotactic factors, combined with the proper signals for growth and survival provided by the BM ..
  52. pmc Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression
    Dingcheng Gao
    Department of Cardiothoracic Surgery, Lehman Brothers Lung Cancer Research Center, Cornell University Medical Center, New York, NY 10065, USA
    Biochim Biophys Acta 1796:33-40. 2009
    Emerging evidence indicates that bone marrow (BM)-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated growth of certain tumors in mice and human...
  53. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    ..The transgenic offspring showed an almost complete lack of bone marrow in newborns, owing to strongly retarded vascular invasion into hypertrophic cartilage and impaired cartilage ..
  54. ncbi An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
    ..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
  55. pmc Bone marrow microenvironment and the identification of new targets for myeloma therapy
    K Podar
    Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics, Dana Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Boston, MA 02115, USA
    Leukemia 23:10-24. 2009
    ..both early and late genetic changes in the tumor cell as well as selective supportive conditions by the bone marrow (BM) microenvironment...
  56. pmc Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
    Cristina Lo Celso
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 457:92-6. 2009
    ..confocal microscopy and two-photon video imaging of individual haematopoietic cells in the calvarium bone marrow of living mice over time, we examine the relationship of haematopoietic stem and progenitor cells to blood ..
  57. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  58. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..plasma cells are nonrecirculatory and lodge in splenic red pulp, lymph node medullary cords, and bone marrow. The factors that regulate plasma cell localization are poorly defined...
  59. pmc The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse
    Rebecca C Furze
    Leukocyte Biology Section, Sir Alexander Fleming Building, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK SW7 2AZ
    FASEB J 22:3111-9. 2008
    In humans, 10(11) neutrophils are released from the bone marrow per day, and these cells have a half-life in the blood of only approximately 6.5 h...
  60. doi Bone marrow-derived mesenchymal stem cells enhanced diabetic wound healing through recruitment of tissue regeneration in a rat model of streptozotocin-induced diabetes
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Plast Reconstr Surg 128:872-80. 2011
    This study investigated whether bone marrow-derived mesenchymal stem cell therapy has effectiveness in the enhancement of diabetic wound healing through tissue regeneration.
  61. ncbi Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    Scott T Avecilla
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 10:64-71. 2004
    ..Here we report that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production...
  62. doi Thymic and bone marrow output in patients with common variable immunodeficiency
    Federico Serana
    Department of Biomedical Science and Biotechnology, University of Brescia, Brescia, Italy
    J Clin Immunol 31:540-9. 2011
    ..The study aims to obtain more information about the immune deficit of common variable immunodeficiency (CVID) patients...
  63. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
    B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not...
  64. doi Eosinophils are required for the maintenance of plasma cells in the bone marrow
    Van Trung Chu
    Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
    Nat Immunol 12:151-9. 2011
    ..It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key ..
  65. doi Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations
    Shuei Liong Lin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:6733-43. 2009
    ..three distinct subpopulations defined by the marker Ly6C, all of which are derived from a single Ly6C(high) bone marrow monocyte population selectively recruited to the kidney...
  66. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals...
  67. doi Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern
    Katharina E Effenberger
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Breast Cancer Res Treat 125:729-38. 2011
    ..Using these antibodies bone marrow aspirates from 391 breast cancer patients (M(0), pT1-3, pN0-3) were screened for the presence of DTC...
  68. doi Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)
    I Kotsianidis
    Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
    Leukemia 23:510-8. 2009
    ..MDS), immune deregulation and autoimmunity in the early stages might lead to ineffective hematopoiesis and bone marrow (BM) failure, whereas late-stage disease is characterized by the immune escape of the malignant clone...
  69. doi The relationship between bone, hemopoietic stem cells, and vasculature
    Sarah L Ellis
    Peter MacCallum Cancer Centre, Melbourne, Australia
    Blood 118:1516-24. 2011
    ....
  70. pmc Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
    Brahmananda R Chitteti
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 115:3239-48. 2010
    ..These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs...
  71. pmc Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer
    A Daskalaki
    Department of Pathology, University General Hospital of Heraklion, Crete 71110, Greece
    Br J Cancer 101:589-97. 2009
    ..rates and evaluate the clinical relevance of cytokeratin-19 (CK-19) mRNA-positive cells in the peripheral blood (circulating tumour cells, CTCs) and bone marrow (disseminated tumour cells; DTCs) of patients with early breast cancer.
  72. pmc Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance
    Nadine N Bewry
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33613, USA
    Mol Cancer Ther 7:3169-75. 2008
    ..The bone marrow is the predominant microenvironment of CML and is a rich source of both soluble factors and extracellular ..
  73. ncbi Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation
    James F Griffith
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, Hong Kong SAR, China
    Radiology 241:831-8. 2006
    ..To prospectively study the relationship among vertebral marrow fat content, marrow diffusion indexes, and marrow and erector spinae muscle perfusion indexes in female subjects with varying bone mineral density...
  74. doi Review: Biological relevance of disseminated tumor cells in cancer patients
    Sabine Riethdorf
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:1991-2006. 2008
    ..assays enable the detection and characterization of disseminated tumor cells (DTC) at the single cell level in bone marrow (BM) as the common homing site of DTC and circulating tumor cells (CTC) in peripheral blood...
  75. doi Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue
    Linyi Peng
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Stem Cells Dev 17:761-73. 2008
    Mesenchymal stem cells (MSCs) isolated from bone marrow (BM), cartilage, and adipose tissue (AT) possess the capacity for self-renewal and the potential for multilineage differentiation, and are therefore perceived as attractive sources ..
  76. doi Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Cell 135:1118-29. 2008
    b>Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells...
  77. ncbi Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells
    Takafumi Yokota
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73190 3048, USA
    Stem Cells 24:13-22. 2006
    ..alpha-actin (alphaSMA) promoter-driven green fluorescent protein (GFP) transgenic mice (alphaSMA-GFP mice) for bone marrow transplantation to evaluate their potential to generate donor-type tissues in irradiation chimeras...
  78. pmc Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    Claire M Edwards
    Department of Cancer Biology, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN 37232, USA
    Blood 111:2833-42. 2008
    ..In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in myeloma counteracts development of osteolytic bone disease...
  79. ncbi Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 70:50-60. 2006
    ..However, potential underlying mechanisms have not yet been investigated...
  80. ncbi Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout mice
    Stéphane Potteaux
    Institut National de la Sante et de la Recherche Medicale, INSERM U689, Centre de Recherché Cardiovasculaire Lariboisière, Paris, France
    Arterioscler Thromb Vasc Biol 26:1858-63. 2006
    ..We examined the role of bone marrow-derived CCR5 in the development of atherosclerotic lesions after 8, 12, or 35 weeks of high-fat diet.
  81. ncbi Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients
    Kjersti Flatmark
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Clin Cancer Res 8:444-9. 2002
    Detection of micrometastatic cells in bone marrow (BM) may potentially be of prognostic value in colorectal cancer (CRC)...
  82. ncbi A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamers
    Ke Tai Guo
    Department of Thoracic, Cardiac, and Vascular Surgery, University Hospital of Tuebingen, Germany
    Stem Cells 24:2220-31. 2006
    Adult mesenchymal stem cells (aMSCs) are a stem cell population present in bone marrow, which can be isolated and expanded in culture and characterized...
  83. ncbi Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
    N D Theise
    Department of Pathology, New York University, School of Medicine, New York, NY 10016, USA
    Hepatology 31:235-40. 2000
    Following a report of skeletal muscle regeneration from bone marrow cells, we investigated whether hepatocytes could also derive in vivo from bone marrow cells...
  84. pmc G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Craig L Semerad
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
    Blood 106:3020-7. 2005
    ..CXC motif, receptor 4), generates signals that regulate hematopoietic progenitor cell (HPC) trafficking in the bone marrow. During granulocyte colony-stimulating factor (G-CSF)-induced HPC mobilization, CXCL12 protein expression in ..
  85. doi Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization
    Sang Mo Kwon
    Stem Cell Translational Research Laboratory, RIKEN Center For Developmental Biology Institute of Biomedical Research and Innovation, Kobe, Japan
    Circulation 118:157-65. 2008
    ..Despite accumulating evidence that proves the pivotal role of endothelial progenitor cells (EPCs) in ischemic neovascularization, the key signaling cascade that regulates functional EPC kinetics remains unclear...
  86. pmc Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cells
    Tanja Fehm
    Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
    Breast Cancer Res 11:R59. 2009
    ..of CTCs in blood, we evaluated the correlation between CTCs and disseminated tumor cells (DTCs) in the bone marrow (BM), and we characterized CTCs for the expression of HER2, the estrogen receptor (ER) and the progesterone ..
  87. pmc On the adaptation of endosteal stem cell niche function in response to stress
    Yi Jiang
    University of Washington, Department of Medicine Hematology, Seattle, WA 98195, USA
    Blood 114:3773-82. 2009
    ..A similar phenotype was observed with cells rendered G(i)-protein signaling incompetent by pertussis toxin treatment, supporting an active stromal-derived factor 1 (SDF-1) gradient near endosteum after irradiation...
  88. pmc CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
    Yu Tzu Tai
    LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 113:4309-18. 2009
    ..CS1 overexpression promoted myeloma cell growth and survival by significantly increasing myeloma adhesion to bone marrow stromal cells (BMSCs) and enhancing myeloma colony formation in semisolid culture...
  89. pmc Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis
    Mattias Fransson
    Laboratory of Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Respir Res 8:17. 2007
    Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood...
  90. doi Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse
    Osamu Imataki
    Division of Hematology, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Int J Clin Oncol 15:112-5. 2010
    ..Although her bone marrow achieved remission after induction therapy, there was a small residual population of leukemic cells in the ..
  91. doi Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α
    Yehuda Kamari
    The Bert Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel
    Biochem Biophys Res Commun 405:197-203. 2011
    ..We assessed whether IL-1α and IL-1β from tissue resident vascular cells or emigrating bone marrow-derived cells promote the development of atherosclerosis in apoE-/- mice and determined the effect of selective ..
  92. pmc Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells
    Ryo Suzuki
    National Institutes of Health, Bethesda, MD 20892 1930, USA
    J Leukoc Biol 88:863-75. 2010
    ..This demonstrates that in addition to a role described previously for Orai1 in promoting MC degranulation, nonselective cation channels participate in promoting the exocytotic response...
  93. doi The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients
    Yanran Cao
    Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 38:860-7. 2010
    The interaction of multiple myeloma (MM) with its bone marrow (BM) microenvironment is important for the homing pattern, survival, and proliferation of malignant plasma cells...
  94. doi Nanobodies as tools for in vivo imaging of specific immune cell types
    Kurt De Groeve
    Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    J Nucl Med 51:782-9. 2010
    ..In the present study, we have evaluated the use of Nanobodies as a generic method for imaging the in vivo biodistribution of specific immune cell types, using myeloid cells as an example...
  95. doi HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer
    Julie E Lang
    Department of Surgical Oncology, MD Anderson Cancer Center, Advanced Research Center for Microscopic Disease, The University of Texas, Houston, TX 77030, USA
    Breast Cancer Res Treat 113:501-7. 2009
    ..We hypothesized that primary tumor characteristics would predict the likelihood of identifying CTCs in patients with operable breast cancer...
  96. doi MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathway
    J Li
    State Key Laboratory of Oral Diseases, West China College of Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    Cell Prolif 43:333-43. 2010
    ..study was carried out to reveal functions and mechanisms of MEK/ERK and p38 pathways in chondrogenesis of rat bone marrow mesenchymal stem cells (BMSCs), and to investigate further any interactions between the mitogen-activated ..
  97. ncbi Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide
    Lee J Goldstein
    Department of Surgery, University of Pennsylvania Medical Center, 4th Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, Pennsylvania 19124, USA
    Stem Cells 24:2309-18. 2006
    ..to be regulated by hypoxic gradients and induced by vascular endothelial growth factor-mediated increases in bone marrow nitric oxide (NO)...
  98. pmc Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections
    Alexander A Navarini
    Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:7107-12. 2009
    ..These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils are ..
  99. pmc Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors
    Andrew C Dudley
    Department of Surgery, Harvard Medical School and Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 116:3367-71. 2010
    The hypothesis that bone marrow-derived, circulating endothelial cells incorporate into tumor blood vessels is unresolved...
  100. doi Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice
    Caroline Marty
    Inserm U1009, Institut Gustave Roussy, PR1, 114 rue Edouard Vaillant, 94805 Villejuif, France
    Blood 116:783-7. 2010
    ..In conclusion, constitutive heterozygous expression of JAK2(V617F) in mice is not embryo-lethal but results in severe PV-like disease with secondary myelofibrosis and not in ET-like disease as expected from patient study...
  101. pmc Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow
    Pratibha Singh
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Stem Cells 26:1009-16. 2008
    Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved in the immune response...

Research Grants87

  1. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..IL-7 plays a critical role in regulation of EBF expression at an early phase of B cell development in adult bone marrow. Dysfunction of IL-7 receptor subunits (either 11-7 receptor alpha or common gamma chains) causes profound ..
  2. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
  3. GENETIC ANALYSIS OF POLARITY
    Ruth Steward; Fiscal Year: 2009
    ..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
  4. DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY SUSCEPTIBILITY EFFECTS IN MRI
    Nir Barzilai; Fiscal Year: 1999
    ..The change in oxygen saturation in sickle cell patients in brain and bone marrow was investigated while the patient was breathing room air or high oxygen through a face mask and comparing the ..
  5. BONE MARROW TRANSPLANTION AND ATHEROSCLEROSIS
    MacRae Linton; Fiscal Year: 1999
    ..The goal of this project is to use murine bone marrow transplantation as a method to investigate the role of the macrophage in atherosclerosis and lipoprotein ..
  6. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2010
    ..Several studies have shown that bone marrow cells can differentiate into hepatocytes, and we have also shown that bone marrow (BM) cells are able to ..
  7. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2010
    ..therapeutic strategy for which the virus is uniquely well-suited: ex vivo purging of cancer cells within human bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell ..
  8. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2009
    ..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
  9. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2010
    ..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
  10. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2003
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  11. G-CSF RECEPTOR AND PROGENITOR MOBILIZATION
    Daniel Link; Fiscal Year: 2001
    ..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
  12. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  13. PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESIS
    ELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2002
    Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
  14. Stem Cell Transplantation for Hemoglobinopathies in Dogs
    JOHN HEARST; Fiscal Year: 2003
    b>Bone marrow transplantation has the potential of providing a complete cure of the disease symptoms of hemoglobinopathies...
  15. Cord Blood Stem Cell Transplantation, Hemoglobinopathies
    JOHN HEARST; Fiscal Year: 2003
    b>Bone marrow transplantation has the potential of providing a complete cure of the disease symptoms of hemoglobinopathies...
  16. Ribosome Biogenesis in Diamond Blackfan Anemia
    Monica Bessler; Fiscal Year: 2007
    Our laboratory has a longstanding interest in the molecular pathogenesis of bone marrow failure, a condition characterized by the inability of the bone marrow to produce sufficient blood cells...
  17. Bone Marrow Angioblasts for Myocardial Vasculogenesis
    Silviu Itescu; Fiscal Year: 2006
    ..We have recently shown that human adult bone marrow contains endothelial progenitors with phenotypic and functional characteristics of embryonic hemangioblasts, ..
  18. Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth Cancers
    JOHN MARTIN BROWN; Fiscal Year: 2010
    ..to cure these tumors despite high dose radiotherapy is the result of regrowth of the tumor vasculature from bone marrow derived cells (BMDCs) following the course of radiotherapy...
  19. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    Studies of bone marrow cells have shown that they can restore neurologic function when transplanted into animals with ischemic brain injury...
  20. IMPROVED CONDITIONS FOR HUMAN HEMATOPOIETIC CELL CULTURE
    ELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 1993
    Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
  21. THE THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2007
    ..Only 10-20 percent are cured by combination chemotherapy. Although allogeneic bone marrow transplantation is potentially curative, only 25 percent of AML patients are eligible for this therapy and only ..
  22. STUDIES ON THE REGULATION OF OSTEOCLAST PRECURSOR CELLS
    Joseph A Lorenzo; Fiscal Year: 2010
    ..Currently, it is unknown whether osteoclast precursor cells, which originate in bone marrow, 1) migrate directly from bone marrow to adjacent bone, where they mature and function as resorbing cells or if ..
  23. The Pathogenesis of Dyskeratosis Congenita
    Philip J Mason; Fiscal Year: 2010
    The long-term goal of this work is to understand the pathogenesis of the rare bone marrow failure syndrome dyskeratosis ongenital (DC) and the reasons for its predisposition to malignancy...