Genomes and Genes
Summary: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Publications275 found, 100 shown here
- SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsMark J Kiel
Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Cell 121:1109-21. 2005..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum...
- Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAsFederica Collino
Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
PLoS ONE 5:e11803. 2010..MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling ..
- Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell nichesTatsuki Sugiyama
Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Immunity 25:977-88. 2006In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear...
- The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move inArmin Ehninger
Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
J Exp Med 208:421-8. 2011..In mammals, the best understood niche is that harboring bone marrow hematopoietic stem cells (HSCs)...
- Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targetsTeru Hideshima
Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Nat Rev Cancer 7:585-98. 2007..The bone marrow microenvironment promotes multiple myeloma cell growth and resistance to conventional therapies...
- Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1T Nagasawa
Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
Nature 382:635-8. 1996..and that although the numbers of B-cell progenitors in mutant embryos were severely reduced in fetal liver and bone marrow, myeloid progenitors were reduced only in the bone marrow but not in the fetal liver, indicating that PBSF/SDF-..
- How do stem cells find their way home?Tsvee Lapidot
Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
Blood 106:1901-10. 2005..hematopoietic stem cells through the blood, across the endothelial vasculature to different organs and to their bone marrow (BM) niches, requires active navigation, a process termed homing...
- Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulpSongtao Shi
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
J Bone Miner Res 18:696-704. 2003Mesenchymal stem cell populations have previously been identified in adult bone marrow and dental pulp that are capable of regenerating the bone marrow and dental pulp microenvironments, respectively...
- CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrowKyle J Eash
Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Clin Invest 120:2423-31. 2010..Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal ..
- Regulation of the HIF-1alpha level is essential for hematopoietic stem cellsKeiyo Takubo
Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
Cell Stem Cell 7:391-402. 2010..Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM)...
- Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker padNarihito Nagoshi
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Cell Stem Cell 2:392-403. 2008..Here we identified NCSCs in the bone marrow (BM), dorsal root ganglia, and whisker pad and prospectively isolated them from adult transgenic mice encoding ..
- Haematopoietic stem cell release is regulated by circadian oscillationsSimon Mendez-Ferrer
Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
Nature 452:442-7. 2008..HSCs and their progenitors fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment...
- Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetesThomas Thum
Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Diabetes 56:666-74. 2007..diabetes, circulating EPCs were reduced to 39 +/- 5% of controls and associated with uncoupled eNOS in bone marrow. Our results identify uncoupling of eNOS in diabetic bone marrow, glucose-treated EPCs, and EPCs from diabetic ..
- CXCL12 and CXCR4 in bone marrow physiologyNatalia M Moll
CRICM INSERM UPMC, UMRS 975 CNRS UMR 7225, Faculte de Medecine Pierre et Marie Curie, Hopital Pitie Salpetriere, 105 bd de l Hopital, 75634 Paris, France
Expert Rev Hematol 3:315-22. 2010This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation...
- Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrowKaren Bieback
Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
Stem Cells 27:2331-41. 2009..Contradictory results with bone marrow (BM)-derived MSCs have initiated a comprehensive comparison of HS, tPRP, and pooled human platelet lysate (pHPL)..
- Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescenceCoralie Martin
Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
Immunity 19:583-93. 2003..evidence that the SDF-1alpha/CXCR4 chemokine axis is involved in both the retention of neutrophils within the bone marrow and the homing of senescent neutrophils back to the bone marrow...
- HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapyChristine M Durand
Department of Medicine, The Sidney Kimmel CancerCenter, USA
J Infect Dis 205:1014-8. 2012..We obtained bone marrow aspirates from 11 patients on ART who had undetectable plasma HIV-1 RNA...
- Awakening dormant haematopoietic stem cellsAndreas Trumpp
Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
Nat Rev Immunol 10:201-9. 2010Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells...
- Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilizationMatthew J Christopher
Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Blood 114:1331-9. 2009..cell (HSPC) mobilization by granulocyte colony-stimulating factor (G-CSF) is mediated by induction of bone marrow proteases, attenuation of adhesion molecule function, and disruption of CXCL12/CXCR4 signaling in the bone ..
- CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapyAbdel Kareem Azab
Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Blood 113:4341-51. 2009The interaction of multiple myeloma (MM) cells with their microenvironment in the bone marrow (BM) provides a protective environment and resistance to therapeutic agents...
- Adult rat and human bone marrow stromal cells differentiate into neuronsD Woodbury
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Neurosci Res 61:364-70. 2000b>Bone marrow stromal cells exhibit multiple traits of a stem cell population. They can be greatly expanded in vitro and induced to differentiate into multiple mesenchymal cell types...
- Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphateRajita Pappu
Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
Science 316:295-8. 2007..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
- Dynamic visualization of thrombopoiesis within bone marrowTobias Junt
Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Science 317:1767-70. 2007Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood...
- Subsets, expansion and activation of myeloid-derived suppressor cellsEliana Ribechini
Institute of Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, Wurzburg, Germany
Med Microbiol Immunol 199:273-81. 2010..Several factors have been described to promote MDSC expansion and activation in bone marrow, spleen and tumor sites...
- Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligandsChao Shi
Immunology Program, Sloan Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 34:590-601. 2011..Monocytes originate from bone marrow and their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic ..
- Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cellsYong Wang
Department of Pathology, Medical University of South Carolina, Charleston, SC 29425, USA
Free Radic Biol Med 48:348-56. 2010..and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM) injury...
- Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathwayAndrea Augello
Laboratory of Regenerative Medicine, National Institute for Cancer Research, Genova, Italy
Eur J Immunol 35:1482-90. 2005b>Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation...
- Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 familyT J Fleming
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
J Immunol 151:2399-408. 1993..FACS analysis using 1A8 demonstrated that Ly-6G was expressed in bone marrow but not substantially on other lymphoid tissues, including activated T and B cells...
- Detection of functional haematopoietic stem cell niche using real-time imagingYucai Xie
Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
Nature 457:97-101. 2009..HSCs home to bone marrow through the vascular system...
- Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cellsAngela Colmone
Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 South Maryland Avenue MC 2115, Chicago, IL 60637, USA
Science 322:1861-5. 2008..imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments that sequester transplanted human CD34+ (HPC-enriched) cells...
- Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow nicheSatoshi Yamazaki
Japan Science and Technology Agency, ERATO, Chiyoda ku, Tokyo 102 0075, Japan
Cell 147:1146-58. 2011Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial...
- CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantationDjordje Atanackovic
Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
Haematologica 93:423-30. 2008..about the number and function of immunosuppressive CD4(+)CD25(+)FOXP3(+) T regulatory cells (Treg) in the human bone marrow and it is unclear whether bone marrow-residing Treg are capable of regenerating following allogeneic stem cell ..
- Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermisUna Riekstina
Faculty of Medicine, University of Latvia, Riga LV 1001, Latvia
Stem Cell Rev 5:378-86. 2009Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues, e.g., bone marrow, adipose tissue, dermis, hair follicles, heart, liver, spleen, dental pulp...
- Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrowSteven G DuBois
Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94143 0106, USA
Pediatr Blood Cancer 54:13-8. 2010..A new method for detecting circulating Ewing sarcoma cells using flow cytometry is described. This strategy exploits the nearly universal expression of CD99 and the lack of expression of CD45 by Ewing sarcoma cells...
- The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistanceMark B Meads
Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Clin Cancer Res 14:2519-26. 2008The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of hematopoietic cells...
- A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myelomaKimberly Noonan
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
Blood 116:3554-63. 2010..Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances ..
- Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applicationsKarina T Wright
Spinal Studies and Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
Stem Cells 29:169-78. 2011Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies...
- Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imagingYuqing Zhang
Boston University School of Medicine, Boston, Massachusetts 02118, USA
Arthritis Rheum 63:691-9. 2011..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
- The bone marrow: a site of neutrophil clearanceSara M Rankin
Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, Exhibition Rd, London, SW7 2AZ, UK
J Leukoc Biol 88:241-51. 2010..current dogma that neutrophils are cleared primarily in the liver and spleen, presenting the evidence that the bone marrow is also an important site of neutrophil clearance under homeostatic conditions...
- Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarctionEwa K Zuba-Surma
Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
J Cell Mol Med 15:1319-28. 2011Adult bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) exhibit a Sca-1(+)/Lin(-)/CD45(-) phenotype and can differentiate into various cell types, including cardiomyocytes and endothelial cells...
- Detection of minimal residual disease in blood and bone marrow in early stage breast cancerSavitri Krishnamurthy
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 116:3330-7. 2010The significance of circulating tumor cells (CTCs) in blood and of disseminated tumor cells (DTCs) in bone marrow (BM) in patients with early stage breast cancer is unclear...
- Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironmentBenedetto Sacchetti
Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
Cell 131:324-36. 2007The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long remained elusive...
- Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injuryJie Ma
Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Acaademy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
Haematologica 92:889-96. 2007..senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchymal stem cells (MSC)...
- Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrowKatia Mareschi
Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
J Cell Biochem 97:744-54. 2006..We isolated and expanded MSCs from bone marrow (BM) of pediatric and young adult donors, to analyze the growth kinetic, immunophenotype, telomere length, ..
- The bone marrow vascular niche: home of HSC differentiation and mobilizationHans Georg Kopp
Weill Medical College of Cornell University, New York, New York, USA
Physiology (Bethesda) 20:349-56. 2005The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells...
- Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysisWolfgang Janni
Frauenklinik der Heinrich Heine Universität, Dusseldorf, Germany
Clin Cancer Res 17:2967-76. 2011The prognostic significance of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a large pooled analysis...
- Microenvironmental niches in the bone marrow required for B-cell developmentTakashi Nagasawa
Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
Nat Rev Immunol 6:107-16. 2006..This article summarizes the recent advances in research on the earliest B-cell precursors, their requisite environmental factors and the cellular niches that supply these factors and maintain B cells during their development...
- Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to M Z Ratajczak
Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
Leukemia 24:976-85. 2010..which major chemoattractant present in peripheral blood (PB) is responsible for the egress of HSPCs from the bone marrow (BM)...
- Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool sizeSebastian Stier
Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Exp Med 201:1781-91. 2005..for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment...
- Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasiA B Reis
Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Departamento de Análises Clínicas Escola de Farmácia, Universidade Federal de Ouro Preto, Minas Gerais, Brazil
Clin Exp Immunol 146:303-11. 2006..Herein, we have assessed the correlation between the clinical status as well as the impact of bone marrow parasite density on the phenotypic profile of peripheral blood leucocytes in 40 Brazilian dogs naturally ..
- Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3I Vande Broek
Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Laarbeeklaan 101, Belgium
Br J Cancer 88:855-62. 2003The restricted bone marrow (BM) localisation of multiple myeloma (MM) cells most likely results from a specific homing influenced by chemotactic factors, combined with the proper signals for growth and survival provided by the BM ..
- Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow nicheLizzia Raffaghello
Laboratory of Oncology, G Gaslini Institute, Genova 15145, Italy
Stem Cells 26:151-62. 2008Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating neutrophils...
- Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal regionFumihiko Ishikawa
Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho Tsurumi ku, Yokohama 230 0045, Japan
Nat Biotechnol 25:1315-21. 2007..They home to and engraft within the osteoblast-rich area of the bone marrow, where AML cells are protected from chemotherapy-induced apoptosis...
- Bone marrow microenvironment and the identification of new targets for myeloma therapyK Podar
Department of Medical Oncology, LeBow Institute for Myeloma Therapeutics, Dana Farber Cancer Institute, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Boston, MA 02115, USA
Leukemia 23:10-24. 2009..both early and late genetic changes in the tumor cell as well as selective supportive conditions by the bone marrow (BM) microenvironment...
- An early haematopoietic defect in mice lacking the transcription factor GATA-2F Y Tsai
Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
Nature 371:221-6. 1994..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
- SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossificationTakako Hattori
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
Development 137:901-11. 2010..The transgenic offspring showed an almost complete lack of bone marrow in newborns, owing to strongly retarded vascular invasion into hypertrophic cartilage and impaired cartilage ..
- Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progressionDingcheng Gao
Department of Cardiothoracic Surgery, Lehman Brothers Lung Cancer Research Center, Cornell University Medical Center, New York, NY 10065, USA
Biochim Biophys Acta 1796:33-40. 2009Emerging evidence indicates that bone marrow (BM)-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated growth of certain tumors in mice and human...
- Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionF Kontgen
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Genes Dev 9:1965-77. 1995..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
- Live-animal tracking of individual haematopoietic stem/progenitor cells in their nicheCristina Lo Celso
Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Nature 457:92-6. 2009..confocal microscopy and two-photon video imaging of individual haematopoietic cells in the calvarium bone marrow of living mice over time, we examine the relationship of haematopoietic stem and progenitor cells to blood ..
- The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrowOwen M Siggs
Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
Nat Immunol 12:434-40. 2011B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not...
- Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligandBeate Heissig
Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
Cell 109:625-37. 2002Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals...
- Thymic and bone marrow output in patients with common variable immunodeficiencyFederico Serana
Department of Biomedical Science and Biotechnology, University of Brescia, Brescia, Italy
J Clin Immunol 31:540-9. 2011..The study aims to obtain more information about the immune deficit of common variable immunodeficiency (CVID) patients...
- Bone marrow-derived mesenchymal stem cells enhanced diabetic wound healing through recruitment of tissue regeneration in a rat model of streptozotocin-induced diabetesYur Ren Kuo
Department of Plastic and Reconstructive Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Plast Reconstr Surg 128:872-80. 2011This study investigated whether bone marrow-derived mesenchymal stem cell therapy has effectiveness in the enhancement of diabetic wound healing through tissue regeneration.
- Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesisScott T Avecilla
Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
Nat Med 10:64-71. 2004..Here we report that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow endothelial cells (BMECs) promote thrombopoietin (TPO)-independent platelet production...
- The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouseRebecca C Furze
Leukocyte Biology Section, Sir Alexander Fleming Building, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK SW7 2AZ
FASEB J 22:3111-9. 2008In humans, 10(11) neutrophils are released from the bone marrow per day, and these cells have a half-life in the blood of only approximately 6.5 h...
- Eosinophils are required for the maintenance of plasma cells in the bone marrowVan Trung Chu
Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
Nat Immunol 12:151-9. 2011..It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key ..
- A coordinated change in chemokine responsiveness guides plasma cell movementsD C Hargreaves
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
J Exp Med 194:45-56. 2001..plasma cells are nonrecirculatory and lodge in splenic red pulp, lymph node medullary cords, and bone marrow. The factors that regulate plasma cell localization are poorly defined...
- Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populationsShuei Liong Lin
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 183:6733-43. 2009..three distinct subpopulations defined by the marker Ly6C, all of which are derived from a single Ly6C(high) bone marrow monocyte population selectively recruited to the kidney...
- Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistanceNadine N Bewry
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33613, USA
Mol Cancer Ther 7:3169-75. 2008..The bone marrow is the predominant microenvironment of CML and is a rich source of both soluble factors and extracellular ..
- Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancerA Daskalaki
Department of Pathology, University General Hospital of Heraklion, Crete 71110, Greece
Br J Cancer 101:589-97. 2009..rates and evaluate the clinical relevance of cytokeratin-19 (CK-19) mRNA-positive cells in the peripheral blood (circulating tumour cells, CTCs) and bone marrow (disseminated tumour cells; DTCs) of patients with early breast cancer.
- Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)I Kotsianidis
Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
Leukemia 23:510-8. 2009..MDS), immune deregulation and autoimmunity in the early stages might lead to ineffective hematopoiesis and bone marrow (BM) failure, whereas late-stage disease is characterized by the immune escape of the malignant clone...
- The relationship between bone, hemopoietic stem cells, and vasculatureSarah L Ellis
Peter MacCallum Cancer Centre, Melbourne, Australia
Blood 118:1516-24. 2011....
- Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression patternKatharina E Effenberger
Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
Breast Cancer Res Treat 125:729-38. 2011..Using these antibodies bone marrow aspirates from 391 breast cancer patients (M(0), pT1-3, pN0-3) were screened for the presence of DTC...
- Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell functionBrahmananda R Chitteti
Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Blood 115:3239-48. 2010..These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs...
- Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluationJames F Griffith
Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, Hong Kong SAR, China
Radiology 241:831-8. 2006..To prospectively study the relationship among vertebral marrow fat content, marrow diffusion indexes, and marrow and erector spinae muscle perfusion indexes in female subjects with varying bone mineral density...
- Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissueLinyi Peng
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Stem Cells Dev 17:761-73. 2008Mesenchymal stem cells (MSCs) isolated from bone marrow (BM), cartilage, and adipose tissue (AT) possess the capacity for self-renewal and the potential for multilineage differentiation, and are therefore perceived as attractive sources ..
- Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivoClaire M Edwards
Department of Cancer Biology, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN 37232, USA
Blood 111:2833-42. 2008..In the present study, we determined whether increasing Wnt signaling within the bone marrow microenvironment in myeloma counteracts development of osteolytic bone disease...
- Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cellsTakafumi Yokota
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73190 3048, USA
Stem Cells 24:13-22. 2006..alpha-actin (alphaSMA) promoter-driven green fluorescent protein (GFP) transgenic mice (alphaSMA-GFP mice) for bone marrow transplantation to evaluate their potential to generate donor-type tissues in irradiation chimeras...
- Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout miceStéphane Potteaux
Institut National de la Sante et de la Recherche Medicale, INSERM U689, Centre de Recherché Cardiovasculaire Lariboisière, Paris, France
Arterioscler Thromb Vasc Biol 26:1858-63. 2006..We examined the role of bone marrow-derived CCR5 in the development of atherosclerotic lesions after 8, 12, or 35 weeks of high-fat diet.
- Review: Biological relevance of disseminated tumor cells in cancer patientsSabine Riethdorf
Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int J Cancer 123:1991-2006. 2008..assays enable the detection and characterization of disseminated tumor cells (DTC) at the single cell level in bone marrow (BM) as the common homing site of DTC and circulating tumor cells (CTC) in peripheral blood...
- Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repairAnne Wilson
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
Cell 135:1118-29. 2008b>Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells...
- Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cellsThomas Thum
Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
Cardiovasc Res 70:50-60. 2006..However, potential underlying mechanisms have not yet been investigated...
- Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patientsKjersti Flatmark
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Clin Cancer Res 8:444-9. 2002Detection of micrometastatic cells in bone marrow (BM) may potentially be of prognostic value in colorectal cancer (CRC)...
- Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablationN D Theise
Department of Pathology, New York University, School of Medicine, New York, NY 10016, USA
Hepatology 31:235-40. 2000Following a report of skeletal muscle regeneration from bone marrow cells, we investigated whether hepatocytes could also derive in vivo from bone marrow cells...
- A new technique for the isolation and surface immobilization of mesenchymal stem cells from whole bone marrow using high-specific DNA aptamersKe Tai Guo
Department of Thoracic, Cardiac, and Vascular Surgery, University Hospital of Tuebingen, Germany
Stem Cells 24:2220-31. 2006Adult mesenchymal stem cells (aMSCs) are a stem cell population present in bone marrow, which can be isolated and expanded in culture and characterized...
- G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrowCraig L Semerad
Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
Blood 106:3020-7. 2005..CXC motif, receptor 4), generates signals that regulate hematopoietic progenitor cell (HPC) trafficking in the bone marrow. During granulocyte colony-stimulating factor (G-CSF)-induced HPC mobilization, CXCL12 protein expression in ..
- Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cellsTanja Fehm
Department of Gynecology and Obstetrics, Calwer Strasse 7, University Hospital of Tuebingen, D 72076 Tuebingen, Germany
Breast Cancer Res 11:R59. 2009..of CTCs in blood, we evaluated the correlation between CTCs and disseminated tumor cells (DTCs) in the bone marrow (BM), and we characterized CTCs for the expression of HER2, the estrogen receptor (ER) and the progesterone ..
- Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularizationSang Mo Kwon
Stem Cell Translational Research Laboratory, RIKEN Center For Developmental Biology Institute of Biomedical Research and Innovation, Kobe, Japan
Circulation 118:157-65. 2008..Despite accumulating evidence that proves the pivotal role of endothelial progenitor cells (EPCs) in ischemic neovascularization, the key signaling cascade that regulates functional EPC kinetics remains unclear...
- MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathwayJ Li
State Key Laboratory of Oral Diseases, West China College of Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
Cell Prolif 43:333-43. 2010..study was carried out to reveal functions and mechanisms of MEK/ERK and p38 pathways in chondrogenesis of rat bone marrow mesenchymal stem cells (BMSCs), and to investigate further any interactions between the mitogen-activated ..
- On the adaptation of endosteal stem cell niche function in response to stressYi Jiang
University of Washington, Department of Medicine Hematology, Seattle, WA 98195, USA
Blood 114:3773-82. 2009..A similar phenotype was observed with cells rendered G(i)-protein signaling incompetent by pertussis toxin treatment, supporting an active stromal-derived factor 1 (SDF-1) gradient near endosteum after irradiation...
- Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapseOsamu Imataki
Division of Hematology, Faculty of Medicine, Kagawa University, Kagawa, Japan
Int J Clin Oncol 15:112-5. 2010..Although her bone marrow achieved remission after induction therapy, there was a small residual population of leukemic cells in the ..
- Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxideLee J Goldstein
Department of Surgery, University of Pennsylvania Medical Center, 4th Floor Silverstein Pavilion, 3400 Spruce Street, Philadelphia, Pennsylvania 19124, USA
Stem Cells 24:2309-18. 2006..to be regulated by hypoxic gradients and induced by vascular endothelial growth factor-mediated increases in bone marrow nitric oxide (NO)...
- Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1αYehuda Kamari
The Bert Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel
Biochem Biophys Res Commun 405:197-203. 2011..We assessed whether IL-1α and IL-1β from tissue resident vascular cells or emigrating bone marrow-derived cells promote the development of atherosclerosis in apoE-/- mice and determined the effect of selective ..
- Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitisMattias Fransson
Laboratory of Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Lund University, Malmo, Sweden
Respir Res 8:17. 2007Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood...
- The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patientsYanran Cao
Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Exp Hematol 38:860-7. 2010The interaction of multiple myeloma (MM) with its bone marrow (BM) microenvironment is important for the homing pattern, survival, and proliferation of malignant plasma cells...
- Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cellsRyo Suzuki
National Institutes of Health, Bethesda, MD 20892 1930, USA
J Leukoc Biol 88:863-75. 2010..This demonstrates that in addition to a role described previously for Orai1 in promoting MC degranulation, nonselective cation channels participate in promoting the exocytotic response...
- Nanobodies as tools for in vivo imaging of specific immune cell typesKurt De Groeve
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
J Nucl Med 51:782-9. 2010..In the present study, we have evaluated the use of Nanobodies as a generic method for imaging the in vivo biodistribution of specific immune cell types, using myeloid cells as an example...
- HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancerJulie E Lang
Department of Surgical Oncology, MD Anderson Cancer Center, Advanced Research Center for Microscopic Disease, The University of Texas, Houston, TX 77030, USA
Breast Cancer Res Treat 113:501-7. 2009..We hypothesized that primary tumor characteristics would predict the likelihood of identifying CTCs in patients with operable breast cancer...
- Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infectionsAlexander A Navarini
Institute for Experimental Immunology and Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 106:7107-12. 2009..These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils are ..
- CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cellsYu Tzu Tai
LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Blood 113:4309-18. 2009..CS1 overexpression promoted myeloma cell growth and survival by significantly increasing myeloma adhesion to bone marrow stromal cells (BMSCs) and enhancing myeloma colony formation in semisolid culture...
- Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrowPratibha Singh
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
Stem Cells 26:1009-16. 2008Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved in the immune response...
Research Grants141 found, 100 shown here
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow. The recipient's bone marrow can then produce new blood cells...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow. The recipient's bone marrow can then produce new blood cells...
- DCTD Human Toxicology and PharmacologyDavid Heimbrook; Fiscal Year: 2013..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
- Biochemistry and Molecular Biology CoreAsish Saha; Fiscal Year: 2009..3%) subpopulation of bone marrow cells that are positive for the transgene (1)...
- Molecular Mechanisms of Parvovirus Gene Expression and ReplicationJianming Qiu; Fiscal Year: 2013..B19V replication is highly restricted to human erythroid progenitor cells (EPCs) in the bone marrow and fetal liver...
- Molecular Mechanisms of Disease Progression in Myeloid MalignancyELIZABETH ANN EKLUND; Fiscal Year: 2013..We found a Gas2-dependent decrease in calpain activity and increase in bcatenin in Bcr-abl+ or Icsbp-/- murine bone marrow cells. Stat3, Stat5 and Xiap proteins are also increased in Icsbp-/- cells in a Gas2/calpain-dependent manner...
- Integrated signaling of eicosanoids in HSC formation and regenerationTrista E North; Fiscal Year: 2013..on PGE2-mediated HSC growth and proliferation will enable targeted therapeutic approaches for the treatment of bone marrow failure states, recovery from chemotherapy, or after HSC transplant...
- Identification of Proteins Important for Male OsteoporosisHong Wen Deng; Fiscal Year: 2013..b>Bone marrow mesenchymal stem cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone ..
- Arginine Availability and Metabolism in the Immune Evasion of H. pyloriKeith T Wilson; Fiscal Year: 2013..Arg2-/-iNOS-/- double knockout mice that will be compared to wild-type (WT), Arg2-/-, and iNOS-/- mice, and bone marrow chimeras will be used, to examine A) H...
- DCTD Human Toxicology and PharmacologyDavid Heimbrook; Fiscal Year: 2011..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
- DCTD Human Toxicology and PharmacologyLARRY ARTHUR; Fiscal Year: 2010..reporters of drug action in tumor, surrogate organ compartments (such as peripheral blood mononuclear cells or bone marrow or buccal keratinocytes) are useful for less invasive monitoring of drug effects than biopsies...
- DCTD Human Toxicology and PharmacologyLARRY ARTHUR; Fiscal Year: 2009
- DCTD Human Toxicology and PharmacologyDavid Heimbrook; Fiscal Year: 2012
- Pluripotent stem cell-derived HSCs: improvements and molecular mechanismsPatrick Cahan; Fiscal Year: 2013DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSC), largely residing in the bone marrow of adult mammals, are the progenitors of all blood cells, including all myeloid and lymphoid lineages...
- Modulation of immune senescence by androgen treatment in aged male macaquesHenryk F Urbanski; Fiscal Year: 2013..on the homeostasis of tissue resident lymphocytes by determining 1) T and B cell subset distribution in bone marrow, lymph nodes, bronchoalveolar lavage, and gut biopsies;and 2) the cytokine milieu of these tissues...
- Role of Sex Chromosome Complement in the CNS during Autoimmune DiseaseSienmi Du; Fiscal Year: 2013..Irradiation bone marrow chimera is a widely used tool in basic immunology to manipulate the immune system independently from other ..
- Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitisClaire Larmonier; Fiscal Year: 2013..A novel mouse model for conditional cell-type specific Parp1 targeting, Parp1/Rag1 double knockout mice, and bone marrow chimeras developed as part of this proposal will be used in the following specific aims: (1) we are planning to ..
- Testing the Therapeutic Potential of iPS Cells for Inherited Skin DiseasesJakub Tolar; Fiscal Year: 2013..Dr. Jakub Tolar was the first to perform clinical trials using systemically delivered allogeneic bone marrow (BM)-derived cells in the treatment of RDEB patients, and for that reason, he was recruited as a PI on this ..
- Regulation of myocardial growth and death by GSK-3Junichi Sadoshima; Fiscal Year: 2013..GSK-3 during pressure overload-induced cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on novel connections between GSK-3 isoforms and their ..
- Long-Acting G-CSF Analog for Treating ARSGEORGE NORBERT COX; Fiscal Year: 2013..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first ..
- Bone Marrow Transplantation for Hematologic Malignancies using Novel RadioimmunotJohn M Pagel; Fiscal Year: 2013..We therefore anticipate rapid translation of the optimized promising pretargeted RIT into our clinical RIT HCT program for AML and MDS. ..
- Anti-inflammatory effects of colitis-induced changes in commensal gut microbesJONATHAN JAMES HANSEN; Fiscal Year: 2013..coli GadAB in experimental IBD's, 3) increase understanding of how IBD's develop, and 4) lead to future studies of manipulating bacterial stress responses for therapeutic purposes. ..
- Dietary Scavenging of Reactive Species in Lung Injury: Role of MacrophagesTHEA NOREEN GOLDEN; Fiscal Year: 2013..Chimeric mice, created by adoptive transfer of green fluorescent protein positive bone marrow cells to wild type recipients, will serve to identif the recruited and resident cell populations...
- Over-Expression of microRNA-126 in Macrophages for Treatment of AtherosclerosisSuzette Laing; Fiscal Year: 2013..Since macrophages derived from bone marrow hematopoietic stem cells (HSC), are key to the initiation and progression of atherosclerosis, the therapeutic ..
- Periostin Regulation of Lung FibrosisBethany B Moore; Fiscal Year: 2013..Our published results using bone marrow chimeric mice indicate that both structural and hematopoietic sources of periostin are required for development ..
- Post-translational regulation of MLL in leukemogenesisANDREW GEORGE MUNTEAN; Fiscal Year: 2013..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound ..
- Post-translational regulation of MLL in leukemogenesisANDREW GEORGE MUNTEAN; Fiscal Year: 2012..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound ..
- Group X sPLA2: Regulator of lipolysis and glucose homeostasisNancy R Webb; Fiscal Year: 2013..To define the role of macrophage-expressed GX sPLA2 in adipose tissue. This will be achieved by performing a bone marrow transplant experiment in which wild-type and GX KO mice will be reconstituted with bone marrow cells derived ..
- Characterization of Genetic Abnormalities in MDS and Their Clinical ImpactRafael Bejar; Fiscal Year: 2012..The specific aims of this proposal are to: (1) study a clinically annotated cohort of 439 bone marrow samples from patients with MDS to determine if the mutations they carry are associated with common clinical ..
- Il-7 receptor signaling in lymphopoiesisMotonari Kondo; Fiscal Year: 2009..IL-7 plays a critical role in regulation of EBF expression at an early phase of B cell development in adult bone marrow. Dysfunction of IL-7 receptor subunits (either 11-7 receptor alpha or common gamma chains) causes profound ..
- Combined neuroprotection and metabolic correction to treat leukodystrophiesERNESTO ROQUE BONGARZONE; Fiscal Year: 2013..to provide the missing enzyme to myelinating glia via infiltrating macrophages after the transplantation of bone marrow cells (BMT) from healthy donors into affected patients...
- Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem CellsRUBIE ANN RAKIAN; Fiscal Year: 2013..The proposed research studies will address the capacity of bone marrow-derived mesenchymal stem cells (MSC) to regenerate the oral mucosa epithelium by mimicking an environment in ..
- Developing a New Therapeutic for the Treatment of Invasive AspergillosisMitchell W Mutz; Fiscal Year: 2013..capacity of calcineurin inhibition has been one of the greatest contributions to our current solid organ and bone marrow transplantation abilities. However, inhibition of HC causes severe immunosuppression and toxicity...
- ROS, Redox Regulation and Novel Targets for Cancer TherapyPeng Huang; Fiscal Year: 2013..We also found that that were highly dependent on the bone marrow stromal cells to alleviate the oxidative stress and promote their survival and drug resistance through ..
- Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasiaBENJAMIN BRAUN; Fiscal Year: 2013..Pathogenic bone marrow progenitors in KrasD12 mice demonstrate: (1) biased differentiation that favors the granulocyte/macrophage (GM) ..
- Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic likRussell S Taichman; Fiscal Year: 2013..analysis demonstrated osteogeneis, significant new bone formation, dense thickening of the trabeculae and bone marrow formation. Most importantly, new bone tissue was derived from the human VSELs...
- The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemiaKira Gritsman; Fiscal Year: 2013..The mainstay of treatment is multi-agent chemotherapy and bone marrow transplantation, both of which have many complications and high mortality...
- Phase 1 Study of Quercetin for the Treatment of Fanconi Anemia Parinda Mehta; Fiscal Year: 2013Project Summary/Abstract Current therapies for children with Fanconi anemia (FA) and bone marrow failure, i.e. androgens or bone marrow transplantation, are associated with significant morbidity and mortality...
- Study DNA repair in preventing MDS and AML after radiation and benzene exposureEDWARD PAUL HASTY; Fiscal Year: 2013..the role that DNA damage/repair plays in disease progression, the impact these genotoxins have on a variety of bone marrow cells including HSCs and vulnerable times of exposure (embryonic development vs. adult)...
- Validation and Development of WEE1 as a therapeutic target in AMLChristopher C Porter; Fiscal Year: 2013..to oncogenic stresses in myeloid progenitor cells and perform immunohistochemistry for Wee1 expression in AML bone marrow biopsy specimens...
- Chronic imaging of cellular dynamics after cortical microhemorrhageChris B Schaffer; Fiscal Year: 2013..These experiments use chimeric animals created through bone marrow transplants to achieve specific labeling of either microglia or macrophages...
- Use of Allogenicity to Stimulate Effector Responses Against Multiple MyelomaChristina N Johnson; Fiscal Year: 2013DESCRIPTION (provided by applicant): Multiple myeloma (MM) is a bone marrow plasma cell cancer with a mortality rate greater than 50%1...
- Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In VivoPaul S Frenette; Fiscal Year: 2013..We will evaluate gain- and loss-of function model systems that promote or reduce senescent PMN clearance in the bone marrow or survival in the circulation...
- Molecular Determinants of Tumor Progression in A Steatolic Liver MicroenvironmentHarold L Moses; Fiscal Year: 2013..In vivo techniques of bone marrow and liver transplantation are proposed to examine cellular mechanisms of action of these MMPs...
- Pro-inflammatory role of megakaryocytes in arthritisPeter A Nigrovic; Fiscal Year: 2013..Megakaryocytes are hematopoietic cells found principally in the bone marrow, where they release large membrane-encapsulated cytoplasmic fragments that mature into normal platelets...
- Innate immunity in Rett pathology and repairJonathan Kipnis; Fiscal Year: 2013..Transplantation of wild type bone marrow into irradiation-conditioned Mecp2-null hosts resulted in engraftment of brain parenchyma by bone marrow-..
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
- GENETIC ANALYSIS OF POLARITYRuth Steward; Fiscal Year: 2009..In the bone marrow and bloth delay in other tissues. Zfrp8 and its human ortholog, PDCD2, are >50% homologous...
- NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSISJohn W Christman; Fiscal Year: 2013..Using reciprocal bone marrow chimera p47phox-/- wt mice, we observed that p47phox-/- bone marrow in wt mice resulted in enhanced NF-[..
- RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem CellsLuis A Ortiz; Fiscal Year: 2013..team of researchers with expertise in the biology of IPF, lung vascular biology, heart failure, and bone marrow derived mesenchymal stem cell (MSC) biology at the University of Pittsburgh and established a collaboration ..
- Analysis of mDia formins in hematopoietic stem cell engraftment and migrationPeng Ji; Fiscal Year: 2013..HSC engraftment and migration are critical for successful bone marrow transplantation, which has become a routine clinical strategy for treating patients with many blood related ..
- Multifunctional nanoparticles to improve treatment of human glioblastomaMiqin Zhang; Fiscal Year: 2013..their poor pharmacokinetics such as poor permeability of the blood-brain barrier (BBB), a short half-life, and bone marrow producing deleterious side-effects...
- Global Genomic and Proteomic Profiling of African Children with Typhoid FeverStephen Obaro; Fiscal Year: 2013..Classifier proteins obtained from our new, custom whole-proteome typhoid fever microarrays will provide new insights of targeted proteins and antibodies for next-generation vaccine development. ..
- Molecular Mechanisms of Host Function Exploitation by Type IV effectors of LegionZhao Qing Luo; Fiscal Year: 2013..First, a sidJ deletion mutant was defective in intracellular growth in both mouse bone marrow-derived macrophages and the amoebae host Dictyostelium discoideum...
- Long-acting growth factors for treating the acute and long term effects of lethalChristie M Orschell; Fiscal Year: 2013..S. government due to the potential threat of a terrorist nuclear attack or nuclear accident. Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first ..
- Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor MicroenvironmeASISH KUMAR GHOSH; Fiscal Year: 2013..that CLL MV and CLL stromal cell interaction results in robust activation of the AKT signaling pathway in CLL-bone marrow stromal cells (BMSC), leading to enhanced production of vascular endothelial growth factor (VEGF), a ..
- Transfusion Induced BMT RejectionJames C Zimring; Fiscal Year: 2012When successful, bone marrow transplantation (BMT) is a cure for non-malignant hematological disorders, including: sickle cell disease, aplastic anemia, thalassemia major, Diamond-Blackfan Anemia and Fanconi Anemia...
- Role of GLIS2 in the Development of Cystic Kidney DiseaseMassimo Attanasio; Fiscal Year: 2013..and Myd88flox/flox;Glis2mut/mut;KspCre double mutants and establishing Tlr2-/-;Glis2mut/mut bone marrow chimeras...
- Beta-catenin is a molecular target of the Fanconi anemia core complexKim Hien T Dao; Fiscal Year: 2013..perturbations in Wnt/beta-catenin signaling in FA-deficient hematopoietic stem cells during development and bone marrow failure in an in vivo model of FA...
- Enhancement of Medullary Erythropoiesis during Anemia by Trib3David Kuhrt; Fiscal Year: 2013..steady state erythropoiesis is unperturbed, but during anemia or ESA administration stress erythropoiesis in bone marrow is compromised...
- Role of EGFR signaling in bone formation and the anabolic actions of PTHLing Qin; Fiscal Year: 2013..how PTH exerts its beneficial effects, but whether these effects include, or are mediated by, a stimulation of bone marrow mesenchymal progenitor activities, is not clear...
- Environmental PPAR Agonists Accelerate Aging of Bone and Impair LymphopoiesisAMELIA RACHEL HAAS BAKER; Fiscal Year: 2013..Our data indicate that TBT is a highly potent activator of PPAR( in bone marrow stromal cells...
- Suppression of established IgE-mediated diseaseFRED DOUGLASS FINKELMAN; Fiscal Year: 2013..First, we will test the hypothesis that effects of the cytokines IL-4 and IL-13 on non-bone marrow derived cells, such as vascular endothelial cells, smooth muscle cells, and intestinal epithelial cells, are ..
- Stem Cell Therapies for Primary Immune DeficiencyGay Crooks; Fiscal Year: 2009..is to delineate the role of the thymic vascular niche in the regulation of homing to the neonatal thymus after bone marrow transplantation (BMT)...
- Molecular Mechanism of Immune Therapy for Bone Marrow FailuresPearlie K Epling Burnette; Fiscal Year: 2009..Several syndromes of T cell-mediated bone marrow failure have similar pathology including aplastic anemia (AA), paroxysmal nocturnal hemaglobinuria (PNH), and a ..
- Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic RetinopathySTEPHEN BARTELMEZ; Fiscal Year: 2009..murine and human hematopoietic stem cells (HSC and EPCs ) accelerates key functions of these cells including 1) bone marrow engraftment, 2) reducing the number of HSC needed for long-term reconstitution, 3) increasing CXCR-4 expression ..
- DETECTION OF HYPOXIA IN SICKLE CELL ANEMIA BY SUSCEPTIBILITY EFFECTS IN MRINir Barzilai; Fiscal Year: 1999..The change in oxygen saturation in sickle cell patients in brain and bone marrow was investigated while the patient was breathing room air or high oxygen through a face mask and comparing the ..
- BONE MARROW TRANSPLANTION AND ATHEROSCLEROSISMacRae Linton; Fiscal Year: 1999..The goal of this project is to use murine bone marrow transplantation as a method to investigate the role of the macrophage in atherosclerosis and lipoprotein ..
- Stem cells in liver regeneration: fusion or plasticityBryon E Petersen; Fiscal Year: 2010..Several studies have shown that bone marrow cells can differentiate into hepatocytes, and we have also shown that bone marrow (BM) cells are able to ..
- Environmental PPAR Agonists Accelerate Aging of Bone and Impair LymphopoiesisAMELIA R HAAS; Fiscal Year: 2010..Our data indicate that TBT is a highly potent activator of PPAR( in bone marrow stromal cells...
- MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENSMary Galinski; Fiscal Year: 2000..b>Bone marrow hypoproliferation (ineffective hematopoiesis) is likely to be a main contributor to the etiology of these ..
- The Role of Interferon-gamma in the Regulation of Hematopoietic Stem CellsKATHERINE YUDEH KING; Fiscal Year: 2010..Cells of the host immune response are ultimately derived from hematopoietic stem cells (HSCs) in bone marrow. I have capitalized on the institutional strength of BCM in the field of stem cell biology to pursue ..
- Myxoma Virus (MV) Oncolysis for treating human cancerGrant McFadden; Fiscal Year: 2010..therapeutic strategy for which the virus is uniquely well-suited: ex vivo purging of cancer cells within human bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell ..
- Innate immunity in Rett pathology and repairJonathan Kipnis; Fiscal Year: 2012..Transplantation of wild type bone marrow into irradiation-conditioned Mecp2-null hosts resulted in engraftment of brain parenchyma by bone marrow-..
- Disease-Modifying Effects of Filgastrim in a Mouse Model of ADJuan Sanchez Ramos; Fiscal Year: 2009..responsible for the decrease in beta-amyloid (A-2) deposition will be tested in a chimeric tg AD mouse in which bone marrow derived cells express green fluorescent protein (GFP)...
- Immune response to Pneumocystis and bone marrow failureNicole Meissner; Fiscal Year: 2010..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
- Immune response to Pneumocystis and bone marrow failureNicole Meissner; Fiscal Year: 2009..in AIDS is the occurrence of progressive pancytopenia (reduction of all blood cells) due to regenerative bone marrow failure. Mechanisms of pancytopenia are poorly understood...
- CYCLIC ORAL ADMINISTRATION OF SCH66336 IN PATIENTS W/ ADVANCED CANCERA Adjei; Fiscal Year: 1999..when administered orally twice daily for 7 out of 21 days in patients with advanced cancer who have no known bone marrow involvement by cancer, 2) to characterize the single- and multiple-dose pharmacokinetics of SCH 66336 following ..
- Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environmHector L Aguila; Fiscal Year: 2010..b>Bone marrow and Hematopoietic Stem Cell (HSC) transplantation are the best proof of concept on the feasibility of ..
- GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLSROBERT BRESSLER; Fiscal Year: 1990..caused the growth of large numbers of histaminecontaining, toluidine blue positive, granulated cells (HCGC) in bone marrow cultures...
- Pathogenesis of Chronic Wasting Disease in Transgenic MiceDAVIS MARTIN SEELIG; Fiscal Year: 2010..murine model of chronic wasting disease (CWD) to addresses sequential prion pathogenesis and the role of bone marrow in prion trafficking and neuroinvasion...
- CELL AND GENE THERAPY IN A MOUSE MODEL OF HUMAN OSTEOGENChristopher Niyibizi; Fiscal Year: 2000..III that has defective synthesis of proalpha2(I) chains to evaluate the feasibility of reversing OI defects by bone marrow stromal cell transplantation or by use of bone marrow stromal cells to deliver therapeutic genes to bone...
- G-CSF RECEPTOR AND PROGENITOR MOBILIZATIONDaniel Link; Fiscal Year: 2001..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
- G-CSF RECEPTOR AND PROGENITOR MOBILIZATIONDaniel Link; Fiscal Year: 2002..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
- G-CSF RECEPTOR AND PROGENITOR MOBILIZATIONDaniel Link; Fiscal Year: 1999..Recently, mobilized peripheral blood HPC instead of bone marrow-derived HPC have been used because of their reduce engraftment times, relative ease of collection, and possibly ..
- G-CSF RECEPTOR AND PROGENITOR MOBILIZATIONDaniel Link; Fiscal Year: 2000
- G-CSF RECEPTOR AND PROGENITOR MOBILIZATIONDaniel Link; Fiscal Year: 2003
- GM-CSF analogs for treating acute radiation syndromeGEORGE NORBERT COX; Fiscal Year: 2010..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired bone marrow hematopoiesis is one of the ..
- GM-CSF analogs for treating acute radiation syndromeGeorge Cox; Fiscal Year: 2009..b>Bone marrow is one of the most sensitive tissues to radiation damage and impaired bone marrow hematopoiesis is one of the ..
- Novel therapies for Fanconi anemiaDAVID A contact WILLIAMS; Fiscal Year: 2010DESCRIPTION (provided by applicant): Fanconi anemia (FA) is a rare recessive syndrome characterized by bone marrow failure, congenital anomalies and a predisposition to malignancy...
- Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMDCatherine M Gordon; Fiscal Year: 2012..current investigators have a longtime interest in how hormonal alterations in this disease lead to changes in bone marrow composition and skeletal losses...
- Correction of neural abnormalities in Hurler syndromePankaj Gupta; Fiscal Year: 2002..neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
- Correction of neural abnormalities in Hurler syndromePankaj Gupta; Fiscal Year: 2003..neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
- PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESISELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2000Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
- PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESISELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2001Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
- PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESISELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 1999Sources of hematopoietic cells for bone marrow transplantation are limited by the supply of compatible donors, the possibility of viral infection, the painful bone marrow harvest procedure, autologous (patient) marrow that is depleted ..
- PO2 AND PH AS POTENT MODULATORS OF HEMATOPOIESISELEFTHERIOS PAPOUTSAKIS; Fiscal Year: 2002
- ESTABLISHMENT OF RHESUS BONE MARROW CHIMERASM Rosenzweig; Fiscal Year: 2000..of life, we have demonstrated persistent chimerism of human hematopoietic cells Chimerism is highest in the bone marrow (5-10% of CD34+ cells are of human phenotype) Chimerism in the peripheral blood varies between mononuclear ..