serum

Summary

Summary: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins.

Top Publications

  1. doi Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)
    Evan M Kroh
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods 50:298-301. 2010
  2. ncbi Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
  3. pmc A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer
    Fabrizio Bianchi
    IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM IEO Campus, Milan, Italy
    EMBO Mol Med 3:495-503. 2011
  4. pmc The human serum metabolome
    Nikolaos Psychogios
    Department of Computing Science, University of Alberta, Edmonton, Canada
    PLoS ONE 6:e16957. 2011
  5. pmc Genome-wide association study identifies multiple loci influencing human serum metabolite levels
    Johannes Kettunen
    Institute for Molecular Medicine Finland, University of Helsinki, Finland
    Nat Genet 44:269-76. 2012
  6. doi Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods
    J van der Valk
    Fac Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
    Toxicol In Vitro 24:1053-63. 2010
  7. doi Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma
    Chunni Zhang
    Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
    Clin Chem 56:1871-9. 2010
  8. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
  9. doi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
  10. ncbi Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program
    Gary L Myers
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Clin Chem 52:5-18. 2006

Detail Information

Publications316 found, 100 shown here

  1. doi Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)
    Evan M Kroh
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods 50:298-301. 2010
    ..circulate in a stable, cell-free form in the bloodstream and that the abundance of specific miRNAs in plasma or serum can serve as biomarkers of cancer and other diseases...
  2. ncbi Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
    We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods.
  3. pmc A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer
    Fabrizio Bianchi
    IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM IEO Campus, Milan, Italy
    EMBO Mol Med 3:495-503. 2011
    ..We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of ..
  4. pmc The human serum metabolome
    Nikolaos Psychogios
    Department of Computing Science, University of Alberta, Edmonton, Canada
    PLoS ONE 6:e16957. 2011
    ..the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome...
  5. pmc Genome-wide association study identifies multiple loci influencing human serum metabolite levels
    Johannes Kettunen
    Institute for Molecular Medicine Finland, University of Helsinki, Finland
    Nat Genet 44:269-76. 2012
    ..7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2...
  6. doi Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods
    J van der Valk
    Fac Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
    Toxicol In Vitro 24:1053-63. 2010
    ..This will decrease the dependence on animal serum, a supplement with an undefined and variable composition...
  7. doi Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma
    Chunni Zhang
    Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
    Clin Chem 56:1871-9. 2010
    ..The discovery of serum microRNAs (miRNAs) and their unique concentration profiles in patients with various diseases makes them attractive,..
  8. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
    Human plasma and serum are widely used matrices in clinical and biological studies. However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices...
  9. doi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
    ..For clinical scale manufacturing, human factors from serum or platelets have been suggested as alternatives to fetal bovine serum (FBS)...
  10. ncbi Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program
    Gary L Myers
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Clin Chem 52:5-18. 2006
    Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment of chronic kidney disease (CKD)...
  11. doi Quantitative assessment of human serum high-abundance protein depletion
    Rene Stempfer
    Molecular Diagnostics, Life Sciences, Austrian Research Centers GmbH ARC, Seibersdorf, Austria
    Electrophoresis 29:4316-23. 2008
    The aim of this study is to quantify the effectivity of the depletion of human high-abundance serum and plasma proteins for improved protein identification and disease marker candidate discovery and to assess the risk of concomitant ..
  12. ncbi Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    Jeongwu Lee
    Neuro Oncology Branch, National Cancer Institute, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:391-403. 2006
    ..These findings suggest that TSCs may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors...
  13. doi High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
    Pasi Soininen
    NMR Metabonomics Laboratory, Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio, Finland
    Analyst 134:1781-5. 2009
    ..two molecular windows that contain the majority of the metabolic information available by 1H NMR from native serum, e.g. serum lipids, lipoprotein subclasses as well as various low-molecular-weight metabolites...
  14. ncbi High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture
    Chia Chyi Liu
    Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    Vaccine 25:19-24. 2007
    ..We have previously reported that large-scale preparation of a low immunogenic EV71 strain can be achieved using serum free microcarrier Vero cell culture in a 2-l bioreactor [Wu SC, Liu CC, Lian WC...
  15. doi Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
    Warwick B Dunn
    Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    Nat Protoc 6:1060-83. 2011
    ..Protocols for serum- and plasma-based metabolic profiling applying gas chromatography-MS (GC-MS) and ultraperformance liquid ..
  16. pmc Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis
    Reem Al-Mubarak
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS Negl Trop Dis 5:e1303. 2011
    ..Various studies have examined lipid metabolism in leprosy, but there has been limited work using whole metabolite profiles to distinguish the clinical forms of leprosy...
  17. ncbi Standardized approach to proteome profiling of human serum based on magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Sven Baumann
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany
    Clin Chem 51:973-80. 2005
    ..The aims of our study were to establish a proteome fractionation technique and to validate a standardized blood sampling, processing, and storage procedure for proteomic pattern analysis...
  18. pmc Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:18889-94. 2008
    ..We performed antigen microarray analysis to characterize patterns of antibody reactivity in MS serum against a panel of CNS protein and lipid autoantigens and heat shock proteins...
  19. pmc Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes
    Ilaria Barchetta
    Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy
    BMC Med 9:85. 2011
    ..Aim of our study was to test the hypothesis of a direct association between hypovitaminosis D and the presence of NAFLD in subjects with various degree of insulin-resistance and related metabolic disorders...
  20. doi Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels
    L Temmerman
    European Molecular Biology Laboratory Mouse Biology Unit, Via Ramarini 32, I 00015 Monterotondo Scalo, Roma, Italy
    Growth Horm IGF Res 20:255-63. 2010
    ..not necessary for systemic circulation of IGF-1, revealing an internal compensation system for maintaining IGF-1 serum concentrations...
  21. doi Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells
    Patrick Horn
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Cytotherapy 12:888-98. 2010
    Culture medium for mesenchymal stromal cells (MSC) is frequently supplemented with fetal calf serum (FCS)...
  22. pmc Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes
    Catherine A Lazaro
    Department of Pathology, University of Washington School of Medicine, K078 Health Sciences Building, Box 357705, Seattle, WA 98195 7705, USA
    Am J Pathol 170:478-89. 2007
    ..This culture system may be used to study the responses of nontransformed human hepatocytes to HCV infection, to analyze serum infectivity, and to clone novel HCVs from infected patients.
  23. ncbi Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue
    Asli Kocaoemer
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Stem Cells 25:1270-8. 2007
    ..However, most isolation and expansion protocols for clinical-scale production of MSCs use fetal calf serum (FCS) as a supplement, which poses a potential risk for infections as well as immunological reactions...
  24. doi Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease
    Jing Ping Lin
    Office of Biostatistics Research, Division of Cardiovascular Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Clin Chem 56:1535-43. 2010
    b>Serum bilirubin has been consistently shown to be inversely related to cardiovascular disease (CVD)...
  25. pmc Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37
    K L Seib
    Molecular Genetics Unit, Novartis Vaccines, Via Fiorentina, 1, 53100 Siena, Italy
    Infect Immun 77:292-9. 2009
    ..All fHBP null mutant strains analyzed were sensitive to killing in ex vivo human whole blood and serum models of meningococcal bacteremia with respect to the isogenic wild-type strains...
  26. pmc miRNAs as serum biomarkers for Duchenne muscular dystrophy
    Davide Cacchiarelli
    Department of Biology and Biotechnology, Institute Pasteur Cenci Bolognetti and IBPM, Sapienza University of Rome, Italy
    EMBO Mol Med 3:258-65. 2011
    ..Despite many different DMD therapeutic approaches are now entering clinical trials, a unifying method for assessing the benefit of different treatments is still lacking...
  27. pmc Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
    Qing Ge
    SomaGenics, Inc, Santa Cruz, California 95060, USA
    RNA 16:118-30. 2010
    ..In this study, the effects of chemical modifications on the potency, serum stability, and innate immune response of sshRNAs were investigated...
  28. doi Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation
    Shu Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS 226001, People s Republic of China
    Cell Mol Neurobiol 28:1067-78. 2008
    The hypoglycemia and serum limitation-induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders...
  29. ncbi LC-MS/MS quantification of Zn-alpha2 glycoprotein: a potential serum biomarker for prostate cancer
    Olga P Bondar
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Clin Chem 53:673-8. 2007
    ..We present a high-flow liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring serum ZAG concentrations by proteolytic cleavage of the protein and quantification of a unique peptide.
  30. doi Association of increased serum IL-33 levels with clinical and laboratory characteristics of systemic lupus erythematosus in Chinese population
    Zaixing Yang
    Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Clin Exp Med 11:75-80. 2011
    ..The aim of this study was to examine whether the serum IL-33 level is associated with SLE. A total of 70 patients with SLE were recruited...
  31. doi High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans
    Andrew M Goetze
    Department of Process and Product Development, Amgen Inc, Thousand Oaks, CA 91320, USA
    Glycobiology 21:949-59. 2011
    ..The therapeutic IgGs were affinity purified from serum samples from human pharmacokinetic studies, and changes to the glycan profile over time were determined by peptide ..
  32. doi Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects
    Daniela Drescher
    BAM Federal Institute for Materials Research and Testing, Richard Willstätter Str 11, 12489 Berlin, Germany
    Anal Bioanal Chem 400:1367-73. 2011
    ..on XTT viability assay, cytotoxicity is shown to be a function of (1) particle concentration and (2) of fetal calf serum (FCS) content in the cell culture medium...
  33. doi Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection
    O Waidmann
    Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Goethe Universität, Frankfurt Main, Germany
    J Viral Hepat 19:e58-65. 2012
    miR-122 is a liver-specific microRNA, which also circulates in the blood. The levels of miR-122 in serum and plasma correlate with hepatic necroinflammation in patients with hepatitis B virus (HBV) infection...
  34. pmc A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI
    Sid E O'Bryant
    Department of Neurology, F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
    PLoS ONE 6:e28092. 2011
    ..There is no rapid and cost effective tool that can be implemented as a front-line screening tool for Alzheimer's disease (AD) at the population level...
  35. doi Differential effect of platelet-rich plasma and fetal calf serum on bone marrow-derived human mesenchymal stromal cells expanded in vitro
    Anja Goedecke
    University Hospital Carl Gustav Carus, Department of Haematology, Dresden, Germany
    J Tissue Eng Regen Med 5:648-54. 2011
    ..Human platelet-rich plasma has been introduced as an alternative serum source but functional differences have so far not been described...
  36. ncbi Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia
    Angel Estella
    Intensive Care Unit, Hospital de Jerez, Spain
    J Infect Dev Ctries 5:540-3. 2011
    ..In this study, we assess the inflammatory response mediated by cytokines at the local and systemic levels in three cases of severe pneumonia caused by Influenza A (H1N1) virus...
  37. doi Serum-induced iron-acquisition systems and TonB contribute to virulence in Klebsiella pneumoniae causing primary pyogenic liver abscess
    Pei Fang Hsieh
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Infect Dis 197:1717-27. 2008
    ..Klebsiella pneumoniae has become the predominant pathogen causing primary pyogenic liver abscess (PLA)...
  38. doi Free thyroid hormones in serum by direct equilibrium dialysis and online solid-phase extraction--liquid chromatography/tandem mass spectrometry
    Bingfang Yue
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108 1221, USA
    Clin Chem 54:642-51. 2008
    ..We describe a direct equilibrium dialysis (ED)-liquid chromatography (LC)/tandem mass spectrometry (MS/MS) method for FT4 and FT3...
  39. pmc Microfluidic isolation and transcriptome analysis of serum microvesicles
    Chihchen Chen
    BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lab Chip 10:505-11. 2010
    ..present an easy and rapid microfluidic immunoaffinity method to isolate microvesicles from small volumes of both serum from blood samples and conditioned medium from cells in culture...
  40. ncbi Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay
    Christine M Pfeiffer
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Clin Chem 50:423-32. 2004
    ..tandem mass spectrometric method coupled to liquid chromatography (LC/MS/MS) as a candidate reference method for 5-methyltetrahydrofolic acid (5MeTHF), 5-formyltetrahydrofolic acid (5FoTHF), and folic acid (FA) in human serum.
  41. ncbi Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute
    M E Bernardo
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    J Cell Physiol 211:121-30. 2007
    ..MSCs are currently expanded in vitro in the presence of fetal calf serum (FCS); however, FCS raises concerns when used in clinical grade preparations...
  42. ncbi Serum and plasma proteomics
    Haleem J Issaq
    Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    Chem Rev 107:3601-20. 2007
  43. doi Development of a high-throughput assay for measuring serum neutralizing antibody against enterovirus 71
    Mei Liang Huang
    Vaccine Research and Development Center, National Health Research Institutes, Taiwan
    J Virol Methods 165:42-5. 2010
    ..The serum neutralizing antibody response is the major indicator of EV71 infection and protective immunity...
  44. pmc Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    Dong Feng Wu
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China
    Lipids Health Dis 9:139. 2010
    The association of rs1044925 polymorphism in the acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene and serum lipid profiles is not well known in different ethnic groups. Bai Ku Yao is a special subgroup of the Yao minority in China...
  45. doi High-abundance proteins depletion for serum proteomic analysis: concomitant removal of non-targeted proteins
    Elisa Bellei
    Department of Laboratory Medicine, Medical Faculty, University Hospital of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy
    Amino Acids 40:145-56. 2011
    In clinical and pharmaceutical proteomics, serum and plasma are frequently used for detection of early diagnostic biomarkers for therapeutic targets...
  46. doi Enrichment of peptides in serum by C(8)-functionalized magnetic nanoparticles for direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis
    Ning Yao
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Chromatogr A 1185:93-101. 2008
    Human serum contains a complex array of proteolytically derived peptides (serum peptidome), which contain biomarkers of preclinical screening and disease diagnosis...
  47. ncbi Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 41:997-1004. 2007
    ..Reports have also shown that serum BDNF is altered in schizophrenic patients treated with antipsychotics...
  48. ncbi Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2'-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury
    Chunying Chen
    Key Laboratory of Nuclear Analytical Techniques and Laboratory for Nanoscale Materials and Related Bio Environmental Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, Peoples Republic of China
    Clin Chem 51:759-67. 2005
    ..In this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative DNA damage, and serum redox status in chronically mercury-exposed ..
  49. pmc Serum proteome and cytokine analysis in a longitudinal cohort of adults with primary dengue infection reveals predictive markers of DHF
    Yadunanda Kumar
    Interdisciplinary Research Group in Infectious Diseases, Singapore MIT Alliance for Research and Technology, Singapore, Singapore
    PLoS Negl Trop Dis 6:e1887. 2012
    ..Consequently, there are no reliable methods currently available for early triage of DHF patients resulting in significant over-hospitalization...
  50. doi Elevated serum levels of high mobility group box 1 (HMGB1) protein in dengue-infected patients are associated with disease symptoms and secondary infection
    Diego Allonso
    Laboratory of Structural Genomics, Biophysics Institute Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil
    J Clin Virol 55:214-9. 2012
    ..Recently, it was observed that both DENV-infected epithelial cells undergoing necrosis and dendritic cells (DCs) are able to release a non-classical pro-inflammatory cytokine called high mobility group box 1 (HMGB1)...
  51. doi Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway
    Chengrong Lu
    The Aviation Medicine Research Lab, General Hospital of Air Force, Fucheng Road 30, Beijing 100036, China
    FEBS Lett 582:2703-8. 2008
    ..Here we show that serum starvation induces H2AX phosphorylation and apoptosis independent of the JNK pathway...
  52. pmc Comparing the MicroRNA spectrum between serum and plasma
    Kai Wang
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 7:e41561. 2012
    ..In this study we focused on different sample types' effects on the spectrum of circulating miRNA in blood. Using serum and corresponding plasma samples from the same individuals, we observed higher miRNA concentrations in serum ..
  53. ncbi Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use
    Norbert Stute
    Bone Marrow Transplant Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 32:1212-25. 2004
    ..One major obstacle for their clinical use is the biosafety of fetal calf serum (FCS), which is a crucial part of all media currently used for the culture of MSC.
  54. doi The effects of serum on the toxicity of manufactured nanoparticles
    Martin J D Clift
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Merchiston Campus, 10 Colinton Road, Edinburgh EH10 5DT, United Kingdom
    Toxicol Lett 198:358-65. 2010
    The aim of the present study was to assess the effects of the presence and absence of serum in NP suspension media in relation to their cytotoxicity, as well as their potential to cause oxidative stress and stimulate pro-inflammatory ..
  55. pmc Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children
    Ravinder Kaur
    Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA
    Pediatr Infect Dis J 30:645-50. 2011
    ..Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children...
  56. ncbi Characterization of a uricase from Bacillus fastidious A.T.C.C. 26904 and its application to serum uric acid assay by a patented kinetic uricase method
    Yunsheng Zhao
    Laboratory of Bioinformatics and Molecular Engineering, Chongqing University of Medical Sciences, Chongqing 400016, People s Republic of China
    Biotechnol Appl Biochem 45:75-80. 2006
    An intracellular uricase from Bacillus fastidious A.T.C.C. 26904 was characterized and evaluated for serum uric acid assay by a patented kinetic uricase method. The active uricase was 151 kDa by gel filtration through Sephadex G-200...
  57. ncbi Growth stimulation leads to cellular senescence when the cell cycle is blocked
    Zoya N Demidenko
    Oncotarget, Albany, New York, USA
    Cell Cycle 7:3355-61. 2008
    ..In the presence of serum, induction of p21 caused senescence, characterized by beta-Galactosidase staining, cell hypertrophy, increased ..
  58. doi Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering
    Islam Hamad
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, U K
    ACS Nano 4:6629-38. 2010
    ....
  59. pmc Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1
    Paul Capewell
    College of Medical, Veterinary and Biological Sciences, Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
    PLoS Negl Trop Dis 5:e1287. 2011
    ..b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T. b. gambiense are able to resist lysis by TLF. There are two distinct sub-groups of T. b...
  60. pmc Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
    D Perna
    Department of Experimental Oncology, European Institute of Oncology, IFOM IEO Campus, Milan, Italy
    Oncogene 31:1695-709. 2012
    The transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts...
  61. doi Serum concentrations of ribavirin and pegylated interferon and viral responses in patients infected with HIV and HCV
    Florence Nicot
    INSERM, U 563, Toulouse, France
    J Med Virol 80:1523-9. 2008
    ..This study investigated the relationship between the serum pegylated interferon and ribavirin concentrations 3 and 6 months after treatment initiation, and treatment outcome ..
  62. doi Aberrant expression of serum miRNAs in schizophrenia
    Wenting Shi
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    J Psychiatr Res 46:198-204. 2012
    ..from the literature, Schizophrenia Gene database, NCBI database, the quantification of the nine miRNAs in the serum samples of 115 patients suffering from schizophrenia and 40 healthy individuals using qRT-PCR and semi-nested qRT-..
  63. doi Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Arch Virol 153:1703-13. 2008
    ..The anti-ORF3 MAbs could capture HEV particles in culture medium and serum at variable efficiency of up to 61 and 49%, respectively, but not those in feces...
  64. doi The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model
    Nuria Maicas
    Department of Pharmacology, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjasot, Valencia, Spain
    Eur J Pharmacol 634:184-91. 2010
    ..Arthritis was induced in C57Black-6 mice by an intraperitoneal injection of serum from arthritic K/BxN mice...
  65. doi A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease
    Taru Tukiainen
    Computational Medicine Research Group, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, P O Box 9203, FI 02015 HUT, Finland
    Biochem Biophys Res Commun 375:356-61. 2008
    A three-molecular-window approach for (1)H NMR spectroscopy of serum is presented to obtain specific molecular data on lipoproteins, various low-molecular-weight metabolites, and individual lipid molecules together with their degree of (..
  66. doi A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells
    Steven Sauerzweig
    Leibniz Institute for Neurobiology IfN, Projectgroup Neuropharmacology, Brenneckestr 6, 39118 Magdeburg, Germany
    Exp Cell Res 315:50-66. 2009
    ..The complete removal of serum might offer a simple way to specifically enrich this fraction of pluripotent embryonic like stem cells in BMSC ..
  67. ncbi Inhibition of vascular smooth muscle cell proliferation by serum from rats treated orally with Gastrodia and Uncaria decoction, a traditional Chinese formulation
    Shijun Wang
    Department of Cardiovascular Disease, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China
    J Ethnopharmacol 114:458-62. 2007
    This study was to investigate the effect of serum from rats treated orally with GUD on vascular smooth muscle cells (VSMCs) proliferation in vitro.
  68. ncbi Higher amount of free circulating DNA in serum than in plasma is not mainly caused by contaminated extraneous DNA during separation
    Naoyuki Umetani
    Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Ann N Y Acad Sci 1075:299-307. 2006
    Circulating DNA isolated from serum and plasma has been shown to be a useful biomarker in various diseases including cancer. Serum reportedly contains a higher amount of free circulating DNA than it does in plasma...
  69. ncbi Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC: potential feasibility for clinical applications
    K Tateishi
    Department of Orthopedics, National Hospital Organization Kure Medical Center, Hiroshima, Japan
    Cell Transplant 17:549-57. 2008
    The aim of this study was to evaluate the effect of human serum (HS) on growth and differentiation capacity of human synovium-derived mesenchymal stem cells (MSC) in comparison to cells grown in fetal bovine serum (FBS)...
  70. doi A highly sensitive method for the detection and genotyping of West Nile virus by real-time PCR
    Dewald Zaayman
    Department of Medical Virology, University of Pretoria, South Africa
    J Virol Methods 157:155-60. 2009
    ..WNV could be identified and typed in serum and brain specimens from a human and horse with neurological disease...
  71. ncbi Circulating cell-free DNA in plasma/serum of lung cancer patients as a potential screening and prognostic tool
    Ashutosh K Pathak
    Department of Thoracic Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77039, USA
    Clin Chem 52:1833-42. 2006
    Evaluation of tumor-specific circulating DNA in plasma/serum is a promising noninvasive diagnostic and prognostic tool requiring only a blood sample, which circumvents the logistic difficulties associated with the use of invasive ..
  72. doi Development of an improved genotyping assay for the detection of hepatitis C virus genotypes and subtypes in Pakistan
    Muhammad Idrees
    Division of Molecular Virology and Molecular Diagnostics, National Centre of Excellence in Molecular Biology, University of the Punjab, 87 West Canal Bank Road, Thokar Niaz Baig, Lahore, Pakistan
    J Virol Methods 150:50-6. 2008
    ..Genotype-specific primers were designed on the basis of 114 HCV isolates. Serum samples with known genotypes were used as positive controls to validate the assay developed and to generate PCR ..
  73. ncbi Lung fibroblast proteoglycan production induced by serum is inhibited by budesonide and formoterol
    Lizbet Todorova
    Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    Am J Respir Cell Mol Biol 34:92-100. 2006
    ..the effects of budesonide, a glucocorticoid, and formoterol, a long-acting beta2-adrenergic agonist, on serum-induced proteoglycan production by human lung fibroblasts...
  74. doi Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development
    Shunsuke Takei
    Department of Histology and Embryology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Am J Physiol Heart Circ Physiol 296:H1793-803. 2009
    ..We studied the effect of bone morphogenetic protein (BMP)-4 in the presence of fetal bovine serum (FBS) on cardiac induction from human H1 ES cells during embryoid body (EB) development...
  75. pmc Peroxisome proliferator-activated receptor delta +294T > C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    Lin Miao
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
    Lipids Health Dis 9:145. 2010
    The association of peroxisome proliferator-activated receptor delta (PPARD) +294T > C polymorphism and serum lipid levels is inconsistent in several previous studies. Bai Ku Yao is an isolated subgroup of the Yao minority in China...
  76. pmc Activation and repression of cellular immediate early genes by serum response factor cofactors
    Seung Min Lee
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 285:22036-49. 2010
    The induction of expression of many cellular immediate early genes (IEG) involves the transcription factor serum response factor (SRF)...
  77. pmc Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors
    Reza Ardehali
    Department of Internal Medicine, Division of Cardiovascular Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:3282-7. 2011
    ..that overexpression of the prosurvival gene BCL2 in mouse embryonic stem cells overrode the requirement of serum factors and feeder cells to maintain mESCs in culture...
  78. pmc Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype
    Alexander W Tarr
    School of Molecular Medical Sciences, The University of Nottingham, A Floor West Block, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Virol 85:4246-57. 2011
    ..In contrast, the neutralization serotype did not correlate with genotype. Instead, serum-derived antibodies displayed a range of neutralization breadth and potency, while different E1E2 glycoproteins ..
  79. pmc Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial
    Jose A Perez-Simon
    Servicio de Hematologia, Instituto de Biomedicina de Sevilla IBIS Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Avenida Manuel Siurot s n 41013 Sevilla, Spain
    Haematologica 96:1072-6. 2011
    This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for the treatment of refractory acute or chronic graft-versus-host disease. Twenty-eight expansions were started...
  80. ncbi Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis
    Jinghai Chen
    Research Center for Cardiovascular Regenerative Medicine, The Ministry of Health of China, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Stem Cells 26:135-45. 2008
    ..Our previous studies have documented that hypoxia and serum deprivation (hypoxia/SD), induced MSCs apoptosis through the mitochondrial apoptotic pathway...
  81. pmc Up-converting phosphor technology-based lateral flow assay for detection of Schistosoma circulating anodic antigen in serum
    Paul L A M Corstjens
    Leiden University Medical Center, Department of Molecular Cell Biology, Bldg 2, S 01 030, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Microbiol 46:171-6. 2008
    Schistosoma sp. circular anodic antigen (CAA) serum concentrations reflect actual worm burden in a patient and are a valuable tool for population screening and epidemiological research...
  82. pmc Detection of dengue virus in saliva and urine by real time RT-PCR
    Telma R Poloni
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Ribeirão Preto14040 903, Sao Paulo, Brasil
    Virol J 7:22. 2010
    ..b>Serum, urine and saliva samples collected from both patients were subjected to real time RT-PCR for DENV detection and ..
  83. ncbi Factors influencing the generation of murine dendritic cells from bone marrow: the special role of fetal calf serum
    Manfred B Lutz
    Institute for Virology and Immunobiology, University of Wuerzburg, 97078, Wuerzburg, Germany
    Immunobiology 212:855-62. 2007
    ..The critical role of FCS in BM-DC cultures and alternative methods using murine sera or serum-free media are discussed.
  84. ncbi Autologous serum application in the treatment of neurotrophic keratopathy
    Yukihiro Matsumoto
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmology 111:1115-20. 2004
    To evaluate the effect of autologous serum application for epithelial disorders in neurotrophic keratopathy (NK).
  85. ncbi Efficient and specific removal of albumin from human serum samples
    Laura F Steel
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Jefferson Center for Biomedical Research, Doylestown, Pennsylvania 18901, USA
    Mol Cell Proteomics 2:262-70. 2003
    Patient serum or plasma is frequently monitored for biochemical markers of disease or physiological status...
  86. pmc Detection of novel sequences related to african Swine Fever virus in human serum and sewage
    Joy Loh
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    J Virol 83:13019-25. 2009
    ..We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV...
  87. doi A well-characterised peak identification list of MALDI MS profile peaks for human blood serum
    Ali Tiss
    The BioCentre and Department of Chemistry, University of Reading, Reading, UK
    Proteomics 10:3388-92. 2010
    MALDI MS profiling, using easily available body fluids such as blood serum, has attracted considerable interest for its potential in clinical applications...
  88. ncbi Factors involved in the germination and inactivation of Bacillus anthracis spores in murine primary macrophages
    Haijing Hu
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    FEMS Microbiol Lett 272:245-50. 2007
    ..Spores were efficiently taken up by primary mouse bone marrow-derived macrophages even in the absence of serum but a minimal amount was required for spore germination and subsequent inactivation...
  89. ncbi Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma
    Lynn A Echan
    The Wistar Institute, Philadelphia, PA 19104, USA
    Proteomics 5:3292-303. 2005
    ..Hence, depletion of major proteins is one potential strategy for enhancing detection sensitivity in serum or plasma...
  90. ncbi A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data
    Michael H Abraham
    Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK
    J Pharm Sci 95:2091-100. 2006
    Literature values of the in vivo distribution (BB) of drugs from blood, plasma, or serum to rat brain have been assembled for 207 compounds (233 data points)...
  91. pmc Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum
    Lisa A Lewis
    Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts, USA
    Infect Immun 77:1112-20. 2009
    ..cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N...
  92. doi Stability of gadolinium-based magnetic resonance imaging contrast agents in human serum at 37 degrees C
    Thomas Frenzel
    Bayer Schering Pharma, Berlin, Germany
    Invest Radiol 43:817-28. 2008
    Assessment of the complex stability and Gd3+ dissociation rate of all marketed gadolinium-based MRI contrast agents (GBCA) in human serum at pH 7.4 and 37 degrees C.
  93. doi Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses
    D D Frisbie
    Orthopaedic Research Center, Colorado State University, 300 West Drake, Fort Collins, CO 80523, United States
    Osteoarthritis Cartilage 16:1196-204. 2008
    ..To discriminate between changes in biomarkers with exercise compared to changes in biomarkers with osteoarthritis (OA) in exercising horses...
  94. pmc Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO(2)
    Oscar Zaragoza
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:6155-64. 2003
    ..In this study, we report that serum can induce capsule growth, and we describe the conditions that induce this effect, not only by serum but also by ..
  95. ncbi Proteomic analysis of human blood serum using peptide library beads
    Lau Sennels
    the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, I 20139 Milan, Italy
    J Proteome Res 6:4055-62. 2007
    Human serum is thought to contain key information for diagnostics of human disease. However, no single technology is currently nor might ever be available to cope with the complexity and dynamic range of the serum proteome...
  96. pmc Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B
    Andrey P Anisimov
    State Research Center for Applied Microbiology, Obolensk, Moscow Region 142279, Russia
    Infect Immun 73:7324-31. 2005
    ..bactericidal action of cationic peptides, such as polymyxin B (PMB), and sensitivity to killing by normal human serum (NHS)...
  97. pmc Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation
    Kiyoshi Tamura
    Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    EMBO J 24:2590-601. 2005
    ..Here, we report that the serum response of the ATF3 gene expression depends on c-myc gene and that the c-Myc complex at ATF/CREB site of the gene ..
  98. doi Pattern of serum autoantibodies allows accurate distinction between a tumor and pathologies of the same organ
    Nicole Ludwig
    Department of Human Genetics, Medical School, Saarland University, Homburg Saar, Germany
    Clin Cancer Res 14:4767-74. 2008
    ..One of the major challenges toward this goal is to prove that seroreactivity profiles do not only allow for identifying a tumor but also allow for distinguishing tumors from other pathologies of the same organ...
  99. ncbi CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Prostate 68:42-9. 2008
    ..Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients.
  100. doi Cancer-specific MALDI-TOF profiles of blood serum and plasma: biological meaning and perspectives
    M A Karpova
    Institute of Biomedical Chemistry, 10 Pogodinskaya Str, Moscow, 119121, Russia
    J Proteomics 73:537-51. 2010
    ..this technology have made it attractive for biomarker discovery and validation across various platforms in blood serum/plasma...
  101. doi Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements
    Karen Bieback
    Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Heidelberg University, Mannheim, Germany
    Tissue Eng Part A 16:3467-84. 2010
    ..For clinical scale manufacturing regulatory agencies recommend to replace fetal bovine serum (FBS) commonly used in MSC expansion media as soon as equivalent alternative supplements are available...

Research Grants93

  1. Pancreas Cancer Specialized Program of Research Excelle*
    Anton Wellstein; Fiscal Year: 2006
    ..the infrastructure and resources to acquire tissues and bodily fluids from patients (Pancreatic Tumor Bank and Serum Detection & Molecular Identification Cores) with an expected 120 curative resections a year...
  2. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..Current enzymatic assays of serum ALT or LDH are either non-specific or not sensitive enough to detect early stages of liver damage, assess ..
  3. Specialized Program of Translational Research In Acute Stroke at the Partners
    Karen Furie; Fiscal Year: 2007
    ..team at Partners have investigated both the activation of matrix metalloproteinases (MMPs) in animals, and the serum markers of oxidative stress in acute stroke patients...
  4. Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
    Pirooz Eghtesady; Fiscal Year: 2010
    ..a strong association between HLHS and prior maternal strep infection, but also elevated anti-human cardiac myosin serum titers in mothers of HLHS babies (as found in patients with rheumatic fever), compared with three control groups...
  5. Urine and Serum Biomarkers for Screening and Diagnosis of Ovarian Cancer
    Anna E Lokshin; Fiscal Year: 2010
    ..We also hypothesize that measuring biomarkers in urine instead of serum could substaitally improve classification power of screening and diagnostic assays...
  6. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    Akira Sekikawa; Fiscal Year: 2010
    ..or higher levels of subclinical atherosclerosis as compared to Whites, (3) the Japanese in Japan had levels of serum marine n-3 fatty acids (marine n-3) higher by >100% than US populations, and (4) serum marine n-3 had a ..
  7. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2010
    ..response to vascular amyloid deposits) are reduced by HUCBC infusion in vivo, with attendant: (a) increased serum levels of A1-40, 42, suggesting efflux from the CNS (b) decreased soluble CD40L serum levels, (c) decreased ..
  8. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2009
    ..response to vascular amyloid deposits) are reduced by HUCBC infusion in vivo, with attendant: (a) increased serum levels of A1-40, 42, suggesting efflux from the CNS (b) decreased soluble CD40L serum levels, (c) decreased ..
  9. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    ..A secondary goal of the proposed study is to explore the potential relationship between APOE 4 allele presence, serum apolipoprotein E protein levels, serum cytokine levels (IL-1, IL-6, IL-8 and IL-10) and development and duration ..
  10. H. influenzae: Role of Sialic Acid in Virulence
    Michael A Apicella; Fiscal Year: 2010
    ..The serum resistant phenotype appears to be a prerequisite for NTHi to initiate systemic infection (acute bronchitis, otitis ..
  11. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Marc Gunter; Fiscal Year: 2009
    ..IGF-I shares sequence homology with insulin and is mitogenic. However, uterine and serum IGF-I levels are regulated by different mechanisms, and it is not known whether they are at all correlated...
  12. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    MARC JAMES GUNTER; Fiscal Year: 2010
    ..IGF-I shares sequence homology with insulin and is mitogenic. However, uterine and serum IGF-I levels are regulated by different mechanisms, and it is not known whether they are at all correlated...
  13. Supplemental Vitamin D and Functional Outcomes in Early Adolescence
    Richard D Lewis; Fiscal Year: 2010
    ..that a significant number of children, particularly those with darker skin pigmentation, have inadequate levels of serum 25-hydroxyvitamin D [25(OH)D]...
  14. Supplemental Vitamin D and Functional Outcomes in Early Adolescence
    Richard Lewis; Fiscal Year: 2009
    ..that a significant number of children, particularly those with darker skin pigmentation, have inadequate levels of serum 25-hydroxyvitamin D [25(OH)D]...
  15. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..This reduces IGF-I activity, but also increases its half-life in blood. In observational studies, high serum IGF-I, low serum IGFBP-3, or a high molar ratio of IGF-I relative to IGFBP-3 are associated with increased risk of ..
  16. Fatty Acid Synthase Inhibitors: Ovarian Cancer Therapy
    ALBERT OWENS; Fiscal Year: 2007
    ..enroll women with recurrent disease that have failed initial therapy and overexpresses FAS, as detected by the serum FAS assay. Serum CA-125 and serum FAS will be added to the usual disease monitors and measures of progression...
  17. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 1993
    ..which have been passed in vitro, to be killed or to resist killing by antibody and complement in normal human serum (NHS)...
  18. PROTEOMICS AND HEPATITIS C: FIBROSIS AND PROGNOSIS
    Glenn Gourley; Fiscal Year: 2005
    ..central hypothesis of this proposal is that proteomic techniques can be used to establish a relationship between serum proteins and hepatic fibrosis that will allow determination of hepatic fibrosis without a liver biopsy in patients ..
  19. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
    ..Prostate-specific antigen (PSA) is widely used for diagnosing and monitoring CaP. However, serum PSA level does not increase significantly until tumor volume exceeds 1cc, and it is inversely related to a tumor's ..
  20. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ..We have found increased serum L-Arg levels in severe colitis vs. moderate colitis or normal controls...
  21. Gene Delivery of P53 in a Tumor-bearing Mouse Model
    ARCHIBALD MIXSON; Fiscal Year: 2007
    ..polymers that in combination with liposomes significantly increased transfection in the presence or absence of serum. To test the overall hypothesis that further understanding of HK enhancement of transfection will facilitate the ..
  22. Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
    Ralph Rabkin; Fiscal Year: 2007
    ..In 2/3 of males with advanced CKD, serum testosterone (TT) levels are reduced and likely contribute to the wasting...