Genomes and Genes
nasal lavage fluid
Summary: Fluid obtained by irrigation or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.
Publications201 found, 100 shown here
- A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitisH Wang
The Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden
Allergy 66:132-40. 2011..In this study, we aimed to identify (i) pathways affected by local GC treatment and (ii) examine if those pathways could be used to find novel markers of local GC treatment in nasal fluids from patients with IAR...
- Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoidsVioletta M Piotrowska
Department of Pediatric Otolaryngology, Medical University of Lodz, Poland
Int J Chron Obstruct Pulmon Dis 5:107-17. 2010..We provide evidence of upper airways disease in COPD, which appears to be related more to patients who currently smoke than to disease severity...
- Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnelBritt Marie Larsson
Department of Public Health Sciences, Division of Occupational and Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Respir Med 104:1912-8. 2010..Our findings may further emphasize asthmatics as a vulnerable group to common air pollutants...
- Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigsK Miyake
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Sizuoka, Japan
Jpn J Pharmacol 85:453-6. 2001..of allergic rhinitis, we determined its effects on the increase of chemical mediator concentrations in nasal lavage fluid following the intranasal antigen challenge in guinea pigs actively sensitized with DNP-Ascaris...
- Nerve growth factor expression and release in allergic inflammatory disease of the upper airwaysA M Sanico
Department of Medicine, Division of Clinical Immunology, and Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
Am J Respir Crit Care Med 161:1631-5. 2000....
- Steroid-sensitive indices of airway inflammation in children with seasonal allergic rhinitisPeter Meyer
Department of Pediatrics, University Hospital, Lund, Sweden
Pediatr Allergy Immunol 14:60-5. 2003..i.d) were determined in children with seasonal allergic rhinitis. Nasal lavage fluid levels of eotaxin, eosinophil cationic protein (ECP), and alpha2-macroglobulin, indicating plasma exudation, ..
- Demonstration of different forms of the anti-inflammatory proteins lipocortin-1 and Clara cell protein-16 in human nasal and bronchoalveolar lavage fluidsM Lindahl
Department of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
Electrophoresis 20:881-90. 1999..Furthermore, the identification of different forms of the two proteins makes possible more detailed studies on the role of these proteins in inflammatory disease processes and anti-inflammatory therapies...
- Changes of symptoms, tear film stability and eosinophilic cationic protein in nasal lavage fluid after re-exposure to a damp office building with a history of floodingG Wieslander
Department of Medical Sciences, Uppsala University and University Hospital, Uppsala, Sweden
Indoor Air 17:19-27. 2007..This illustrates the limitations of air measurements of microbial exposures in damp buildings...
- Expression of ICAM-1 in nasal epithelium and levels of soluble ICAM-1 in nasal lavage fluid during human experimental rhinovirus infectionBirgit Winther
University of Virginia Health System, Department of Internal Medicine, Box 800473, Charlottesville, VA 22908, USA
Arch Otolaryngol Head Neck Surg 128:131-6. 2002..examined with immunohistochemical staining of nasal scrape biopsy specimens, and levels of soluble ICAM-1 in nasal lavage fluid were measured by sandwich enzyme-linked immunosorbent assay technique...
- Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift studyMonika Raulf-Heimsoth
Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Institut der Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
Arch Toxicol 81:35-44. 2007..Humoral and cellular parameters were measured in nasal lavage fluid (NALF) and induced sputum...
- Aspergillus fumigatus challenge increases cytokine levels in nasal lavage fluidH Stark
Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
Inhal Toxicol 18:1033-9. 2006..levels (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, IL-4, IL-6, interferon [IFN]-gamma) in nasal lavage fluid (NAL) compared with that evoked by placebo challenge...
- PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluidB Ghafouri
Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, , , Sweden
Biochem Soc Trans 31:810-4. 2003..We have identified two forms of the PLUNC protein in human nasal lavage fluid (NLF) using two-dimensional gel electrophoresis (2-DE) and MS...
- Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patientsLinda M Benson
Mayo Proteomics Research Center, Mayo Clinic, Rochester, MN, USA
J Sep Sci 32:44-56. 2009..To enhance the detection of lower abundance proteins, intact nasal lavage fluid (NLF) proteins from nonpolypoid AR and from asthmatic CRS patients were extensively fractionated prior to LC/..
- The kinetics of allergen-induced eotaxin level in nasal lavage fluid: its key role in eosinophil recruitment in nasal mucosaN Terada
Department of Otorhinolaryngology, Chiba University School of Medicine, Chiba, Japan
Am J Respir Crit Care Med 164:575-9. 2001..challenge led to parallel increases in eosinophil counts, levels of EPX, and eotaxin concentrations in nasal lavage fluid. The levels of eotaxin in lavage samples showed strong correlation with lavage levels of eosinophil counts ..
- Gene profiling reveals decreased expression of uteroglobin and other anti-inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitisM Benson
Laboratory for Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
Clin Exp Allergy 35:473-8. 2005..Little is known about anti-inflammatory mediators in IAR. DNA microarrays allow simultaneous analysis of the whole transcriptome in a sample...
- [Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]Radosław Gawlik
Katedra i Klinika Chorob Wewnetrznych, Alergologii i Immunologii Klinicznej Slaskiego Uniwersytetu Medycznego w Katowicach
Otolaryngol Pol 61:567-71. 2007..Increase in concentration of endothelin-1 in nasal lavage fluid from allergic patients were significantly higher than in control group respectively from 18.33 +/- 5...
- Measuring plasma exudation in nasal lavage fluid and in induced sputum as a tool for studying respiratory tract inflammationD A van Zuijlen
Department of Otorhinolaryngology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
J Immunol Methods 256:1-10. 2001..Determination of plasma exudation together with RCE in NAL and induced sputum is a good, non-invasive way to quantify inflammation of airway mucosa...
- PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharideBijar Ghafouri
Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
Biochim Biophys Acta 1699:57-63. 2004Here, we demonstrate the presence of multiple isoforms of palate lung nasal epithelial clone (PLUNC) in human nasal lavage fluid (NLF)...
- Effects of TNFalpha on the human nasal mucosa in vivoHenrik Widegren
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Respir Med 101:1982-7. 2007..Increased nasal mucosal output of TNFalpha has been demonstrated in allergic rhinitis, but the effect of TNFalpha on the human nasal mucosa has not been examined in vivo...
- Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometryMalin Bryborn
Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
Respir Res 6:118. 2005..DNA microarrays have recently made it possible to compare mRNA profiles of lavage fluids from healthy and diseased patients, whereas information on the protein level is still lacking...
- Nasal lavage fluid examination and rhinomanometry in the diagnostics of occupational airway allergy to laboratory animalsAnna Krakowiak
Department of Occupational Diseases, Nofer Institute of Occupational Medicine, , Poland
Int J Occup Med Environ Health 16:125-32. 2003OBJECTIVES: The purpose of this studywas to compare the cellular and biochemical findings in the nasal lavage fluid (NALF) and nasal resistance changes due to a challenge with laboratory animal allergens in 25 patients with occupational ..
- Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control studyG Rohde
University Hospital Bergmannsheil, Department of Internal Medicine, Division of Pneumology, Allergology and Sleep Medicine, D 44789 Bochum, Germany
Thorax 58:37-42. 2003..Many exacerbations are believed to be due to upper and/or lower respiratory tract viral infections, but the incidence of these infections in patients with COPD is still undetermined...
- Relationships among bacteria, upper airway, lower airway, and systemic inflammation in COPDJohn R Hurst
Academic Unit of Respiratory Medicine, Dominion House, St. Bartholomew's Hospital, London, EC1A 7BE, UK
Chest 127:1219-26. 2005..This study is the first to report a correlation between the degree of upper and lower airway inflammation in COPD...
- Circulating neutrophil CD14 expression and the inverse association of ambient particulate matter on lung function in asthmatic childrenErik R Svendsen
Office of Research and Development, EPA, Research Triangle Park, North Carolina 29208, USA
Ann Allergy Asthma Immunol 99:244-53. 2007....
- Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of lifeD James Nokes
Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
J Infect Dis 190:1828-32. 2004..RSV contributed significantly to total LRTI disease in this vaccine-target group...
- Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometryBegona Casado
Division of Rheumatology, Georgetown University, Washington, DC, USA
Electrophoresis 25:1386-93. 2004..The proteomic approach presented here allowed us to identify, in the high complexity of acute sinusitis nasal secretions, the proteins that respond to a pharmacological treatment and that could be suitable as markers of this pathology...
- Eosinophilia and cell activation mediators in nasal secretionsClotilde Besançon-Watelet
Laboratoire d Immunologie du CHU, Faculte de Medecine, 54505, Vandoeuvre les Nancy Cedex, France
Laryngoscope 112:43-6. 2002..We assayed the levels of these three molecules in nasal secretions in correlation with cytologic findings and especially the degree of eosinophilia...
- Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicinYou Sook Cho
Division of Allergy and Rheumatology, Department of Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
J Allergy Clin Immunol 112:695-701. 2003..The exact mechanism of a chronic nonproductive cough is sometimes unclear when patients who are without symptoms or signs indicating the major causes of chronic cough remain undiagnosed...
- Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildrenAlbino Barraza-Villarreal
Instituto Nacional de Salud Publica, Cuernavaca, Mexico
Environ Health Perspect 116:832-8. 2008..The biological mechanisms involved in inflammatory response to air pollution are not clearly understood...
- Nasal and ocular symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-dampness and building design in hospitalsG Wieslander
Department of Medical Sciences, Department of Occupational and Environmental Medicine, University Hospital, Uppsala University, S 751 85, Uppsala, Sweden
Int Arch Occup Environ Health 72:451-61. 1999..To study the relationships between dampness in concrete floors and building design on the one hand, and symptoms and medical signs of the eyes and nose in hospital workers, on the other...
- Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary diseaseJohn R Hurst
F.R.C.P, Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital London NW3 2PF UK
Am J Respir Crit Care Med 173:71-8. 2006..CONCLUSIONS: Exacerbation of COPD is associated with pan-airway inflammation; the systemic inflammatory response is proportional to that occurring in the lower airway and greater in the presence of a bacterial pathogen...
- Protein patterns of human nasal and bronchoalveolar lavage fluids analyzed with two-dimensional gel electrophoresisM Lindahl
Department of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
Electrophoresis 19:3222-9. 1998We have previously described the protein patterns of human nasal lavage fluid (NLF) and bronchoalveolar lavage fluid (BALF) after two-dimensional gel electrophoresis (2-DE)...
- Nitric oxide and proinflammatory cytokines in nasal lavage fluid associated with symptoms and exposure to moldy building microbesM R Hirvonen
Division of Environmental Health, National Public Health Institute, Kuopio, Finland
Am J Respir Crit Care Med 160:1943-6. 1999..concentrations of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and nitric oxide (NO) in nasal lavage fluid were significantly higher in the exposed than in the control subjects at the end of the first exposure ..
- Traffic-related air pollution affects peak expiratory flow, exhaled nitric oxide, and inflammatory nasal markersP A Steerenberg
Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Arch Environ Health 56:167-74. 2001..In summary, urban children had increased levels of inflammatory nasal markers, and their responses were more pronounced than were the suburban children's responses to the same increments of air pollution...
- Interleukin-5 and interleukin-8 in relation to eosinophils and neutrophils in nasal fluids from school children with seasonal allergic rhinitisM Benson
Department of Pediatrics, Sahlgrenska University Hospital, Goteborg, Sweden
Pediatr Allergy Immunol 10:178-85. 1999..IL-5 levels and relative eosinophil counts in nasal lavage fluid increased significantly in patients with allergic rhinitis during the pollen season, compared with values ..
- Time-dependent observations of secretion marker levels in nasal secretion after histamine and methacholine provocationsMałgorzata Pupek
Department of Chemistry and Immunochemistry, Wrocław Medical University, Bujwida 44a, 50 345 Wrocław, Poland
Arch Immunol Ther Exp (Warsz) 51:259-65. 2003..These observations suggest a time- and dose-dependent, non-specific dysfunction of local immunity response after nasal provocations...
- [Myeloperoxidase (MPO) as a marker of neutrophil influx into nasal mucosa after recombinant IL-8 challenge]Maciej Kupczyk
Pneumonol Alergol Pol 70:544-9. 2002..258, p = 0.42). Due to the lack of statistically confirmed relationship between MPO level and the number of neutrophils, MPO seems to be of little value as a marker of neutrophil influx into nasal mucosa...
- Effects of corticosteroids on expression of interleukin-18 in the airway mucosa of a mouse model of allergic rhinitisSi Whan Kim
Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Seoul National University, Seoul, Korea
Ann Otol Rhinol Laryngol 116:76-80. 2007..In this study, we aimed to investigate the release and response of interleukin (IL)-18 to steroid treatment in a mouse model of allergic rhinitis...
- Preliminary study on Japanese cedar pollinosis in an artificial exposure chamber (OHIO Chamber)Kazuhiro Hashiguchi
Department of Otolaryngology, Kitasato Institute Hospital, Minatoku, Tokyo, Japan
Allergol Int 56:125-30. 2007..Since satisfactory outcomes were obtained from the controlled pollen exposure at the chamber, we conducted preliminary studies in volunteers with SAR...
- Characteristics of eosinophils migrating around fungal hyphae in nasal dischargeKensuke Watanabe
Department of Otorhinolaryngology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
Ann Otol Rhinol Laryngol 113:200-4. 2004..This structure detected in eosinophils has not been reported previously, and is considered to be an interesting finding from the viewpoint of the function of eosinophils...
- Does nitrogen dioxide affect inflammatory markers after nasal allergen challenge?Charlotte Barck
Division of Respiratory Medicine and Allergology, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
Am J Rhinol 19:560-6. 2005..Exposure to high ambient levels of nitrogen dioxide (NO2) enhances the bronchial inflammatory reaction to allergen in humans. We tested whether this NO2 effect occurs also in the upper airways...
- Collection of nasal secretions for immunological analysisJean Baptiste Watelet
Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
Eur Arch Otorhinolaryngol 261:242-6. 2004..The method is non-invasive, well standardized and reproducible and therefore may serve as a valid tool for future investigations...
- Swine dust exposure is a model for rapid induction of non-allergic neutrophil inflammation in the nasal mucosa of healthy volunteers, and the symptoms as well as the microcirculation are modified by nasal lavageAnders Ehnhage
Department of Clinic Sience, Intervention an Technology, Division of Otorhinolaryngology, Karolinska Institutet, Huddinge, Stockholm, Sweden
Rhinology 45:292-8. 2007..In this study the aim was to investigate the effects of swine dust exposure on nasal symptoms as well as the microcirculation. Furthermore, the effect on nasal lavage was investigated...
- Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot studyGiorgio Ciprandi
Allergologia U O ORL, Dipartimento Regionale Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, 16132, Genoa, Italy
Int Immunopharmacol 5:1800-8. 2005..Nasal obstruction is the main symptom in patients with perennial allergic rhinitis. Some new antihistamines have been demonstrated to be capable of improving this symptom...
- Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challengeE M Erin
National Heart and Lung Institute (NHLI) Clinical Studies Unit, Imperial College, London, UK
Clin Exp Allergy 35:1608-14. 2005..CONCLUSION: Fluticasone propionate has selective inhibitory effects on Th2 cytokine synthesis following nasal challenge, while also decreasing release of chemokines, but not affecting levels of Th1 cytokines...
- Vascular endothelial growth factor produced in nasal glands of perennial allergic rhinitisShoji Matsune
Department of Otolaryngology, Head and Neck Surgery, Field of Sensory Organology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Am J Rhinol 22:365-70. 2008..This study was designed to investigate and discuss the pathophysiological significance of VEGF in nasal secretions from perennial allergic rhinitis sufferers...
- Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challengeE M Erin
National Heart and Lung Institute (NHLI) Clinical Studies Unit, Imperial College, London, UK
Allergy 60:1524-9. 2005..the effects of a single dose of topical steroid on eosinophils and levels of chemokines and cytokines in nasal lavage fluid following NAC in patients with allergic rhinitis...
- Stronger nasal responsiveness to cold air in individuals with rhinitis and asthma, compared with rhinitis aloneL S Hanes
Department of Pediatrics, Children's Hospital of New York-Presbyterian, Columbia University, NewYork, NY, USA
Clin Exp Allergy 36:26-31. 2006..This observation is consistent with the notion that compared with rhinitis alone, the presence of asthma and rhinitis signifies a higher degree of functional abnormality of the entire airway...
- Bet v 1-specific IgA increases during the pollen season but not after a single allergen challenge in children with birch pollen-induced intermittent allergic rhinitisChristina Keen
Department of Pediatrics, Goteborg University, Queen Silvia Children s Hospital, Goteborg, Sweden
Pediatr Allergy Immunol 16:209-16. 2005..These findings are compatible with the hypothesis that allergen-specific IgA plays a role in the allergic inflammation and further studies are needed to clarify the functional role of these allergen-specific antibodies...
- Composition of nasal airway surface liquid in cystic fibrosis and other airway diseases determined by X-ray microanalysisV Vanthanouvong
Department of Medical Cell Biology, University of Uppsala, and Cystic Fibrosis Center, Uppsala University Hospital, Uppsala, Sweden
Microsc Res Tech 69:271-6. 2006....
- Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitisYu Zhao
Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Ann Allergy Asthma Immunol 96:844-50. 2006..The thromboxane B2 level in nasal lavage fluid was significantly deceased in the Shu-Bi-Lin-treated group; however, the reduction in histamine and peptide ..
- Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigenMarc A Riedl
Hart and Louis Lyon Laboratory, Division of Clinical Immunology and Allergy, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
J Immunol 174:7440-5. 2005..Whether this immune response represents durable allergic tolerance is not yet known. Studies investigating the molecular mechanisms of this non-IgE response may be useful in developing therapy to prevent allergic sensitization...
- Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposureC A Ahlstrom-Emanuelsson
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, 221 84 Lund, Sweden
Eur Respir J 24:750-7. 2004..Furthermore, nasal lavage fluid levels of eosinophil cationic protein (ECP) and alpha2-macroglobulin were assessed as indices of eosinophil ..
- Inflammatory profile in nasal secretions of infants hospitalized with acute lower airway tract infectionsPaulo M C Pitrez
Division of Clinical Sciences, Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia
Respirology 10:365-70. 2005..05). Neutrophils were the predominant cells in the cytological analysis in all subjects. CONCLUSION: These data argue that host-response factors are important in determining the clinical phenotype, independent of the causative virus...
- Nasal responses in asthmatic and nonasthmatic subjects following exposure to diesel exhaust particlesJohny Kongerud
Lungeavdelingen, Rikshospitalet, University of Oslo, Oslo, Norway
Inhal Toxicol 18:589-94. 2006..Nasal cell populations and soluble mediators in the nasal lavage fluid were characterized...
- Neuropathology in rhinosinusitisJames N Baraniuk
Division of Rheumatology, Immunology and Allergy, Georgetown University, 3800 Reservoir Road, N W, Washington, DC 20007 2197, USA
Am J Respir Crit Care Med 171:5-11. 2005..CFS had neural hypersensitivity (pain) but reduced serous cell secretion. HTS nasal provocations identified significant, unique patterns of neural and mucosal dysregulation in each rhinosinusitis syndrome...
- Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitisAnna Wedbäck
Lung and Allergy Clinic, County Hospital, Halmstad, Sweden
Rhinology 43:86-92. 2005..SNAR seems to be different from SAR and PNAR regarding immunological mechanism and symptom period. We conclude that the cause of SNAR is unknown...
- Targeting adenosine receptors in the treatment of allergic rhinitis: a randomized, double-blind, placebo-controlled studyJ Rimmer
Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
Clin Exp Allergy 37:8-14. 2007..There is evidence that adenosine plays a role in the pathogenesis of asthma and rhinitis; however, it is currently unclear whether adenosine receptors are useful therapeutic targets in the treatment of allergic airway diseases...
- Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitisG Ciprandi
Allergy and ENT Division, Head Neck Dpt, San Martino Hospital, Genoa
Allerg Immunol (Paris) 36:237-40. 2004..007). This study shows the cetirizine effectiveness in exerting anti-inflammatory activity by modulating cytokine pattern and by reducing inflammatory infiltration in children with perennial allergic rhinitis...
- Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitisJi-Hun Mo
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
Am J Rhinol 20:212-8. 2006..Interleukin-5 level was decreased and interferon gamma level was increased in nasal lavage fluid by injection of ISS-ODN/Der f conjugate...
- Epithelial shedding is associated with nasal reactions to cold, dry airAlvaro A Cruz
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224-6801, USA
J Allergy Clin Immunol 117:1351-8. 2006..CLINICAL IMPLICATIONS: A defect in mucosal water homeostasis may need to be considered in individuals who get excessive nasal symptoms when exposed to cold and dry, windy environment...
- A role for neutrophils in intermittent allergic rhinitisMattias Fransson
Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
Acta Otolaryngol 124:616-20. 2004..The aim of this study was to examine the correlation between inflammatory cells in the nasal lavage fluid and clinical parameters following pollen challenge.
- Effects of intranasal fluticasone and salmeterol on allergen-induced nasal responsesK Parameswaran
Firestone Institute for Respiratory Health, St Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Canada
Allergy 61:731-6. 2006..bid), their combination, and placebo, on nasal symptoms, eosinophil differential cell count and albumin in nasal lavage fluid (measures of inflammation and leakage respectively) and nasal electrical potential difference (measure of ..
- Nasal lavage fluid and proteomics as means to identify the effects of the irritating epoxy chemical dimethylbenzylamineMats Lindahl
Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
Biomarkers 9:56-70. 2004The aims of this study were to describe the changes in the nasal lavage fluid (NLF) protein pattern after exposure to the irritating epoxy chemical dimethylbenzylamine (DMBA) and to identify the affected proteins using a proteomic ..
- Evaluation of nasal barrier dysfunction at acute- and late-phase reactions in a guinea pig model of allergic rhinitisSofia Elovsson
Department of Clinical Study Management, AstraZeneca R and D Lund, Sweden
Vascul Pharmacol 43:267-76. 2005..We suggest that this model of guinea pig allergic rhinitis with the early and late responses may be useful for high-throughout screening of new drugs...
- Airway function and nasal inflammation in seasonal allergic rhinitis and asthmaG Ciprandi
Ospedale San Martino, Genoa, Italy
Clin Exp Allergy 34:891-6. 2004..Allergic rhinitis (AR) and asthma are frequently associated and characterized by a Th2-dependent inflammation. Nasal and bronchial obstruction may be objectively measured...
- The effect of recombinant interleukin-8 on eosinophils' and neutrophils' migration in vivo and in vitroM Bocheńska-Marciniak
Department of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland
Allergy 58:795-801. 2003..The objective of this study was to investigate the effect of nasal instillation of IL-8 on the influx of inflammatory cells...
- Pituitary adenylate cyclase-activating polypeptide, effects in the human noseJ Kinhult
Laboratory for Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, , Malm, Sweden
Clin Exp Allergy 33:942-9. 2003....
- Changes in airway inflammation following nasal allergic challenge in patients with seasonal rhinitisM Bonay
, , Paris Cedex, France
Allergy 61:111-8. 2006....
- DNA microarray analysis of transforming growth factor-beta and related transcripts in nasal biopsies from patients with allergic rhinitisMikael Benson
Allergy Laboratory, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
Cytokine 18:20-5. 2002..Low expression of TGF-beta-inducible transcripts may indicate decreased TGF-beta activity in allergic rhinitis. DNA microarray analysis may be a way to study cytokine effects in vivo...
- Hypertonic saline nasal provocation and acoustic rhinometryJ N Baraniuk
Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC 20007, USA
Clin Exp Allergy 32:543-50. 2002..Hypertonic saline (HTS) acts as an airway irritant in human nasal mucosa by stimulating nociceptive nerves and glandular secretion. HTS does not change vascular permeability. In asthma, HTS causes airflow obstruction...
- No involvement of interleukin-5 or eosinophils in experimental allergic rhinitis in guinea pigsMasashi Yamasaki
Department of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, 607 8414, Kyoto, Japan
Eur J Pharmacol 439:159-69. 2002....
- Nasal and otologic effects of experimental respiratory syncytial virus infection in adultsCraig A Buchman
Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
Am J Otolaryngol 23:70-5. 2002..These findings provide further support for the relationship between viral upper respiratory tract infections and otitis media...
- Hot, humid air increases cellular influx during the late-phase response to nasal challenge with antigenP Assanasen
The Section of Otolaryngology-Head and Neck Surgery, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Clin Exp Allergy 31:1913-22. 2001..Increasing eosinophil number had no effects on the hyper-responsiveness to histamine. We speculate that the physical conditions of air differentially impact the stages of allergic inflammation...
- Superiority of an intranasal corticosteroid compared with an oral antihistamine in the as-needed treatment of seasonal allergic rhinitisS M Kaszuba
Section of Otolaryngology-Head and Neck Surgery, University of Chicago, 5841 S Maryland Ave, Mail Code 1035, Chicago, IL 60637, USA
Arch Intern Med 161:2581-7. 2001..70, P<.01). CONCLUSION: As-needed intranasal corticosteroids reduce allergic inflammation and are more effective than as-needed H(1) receptor antagonists in the treatment of seasonal allergic rhinitis...
- Elevations of local leukotriene C4 levels during viral upper respiratory tract infectionsDeborah A Gentile
Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Ann Allergy Asthma Immunol 91:270-4. 2003..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
- Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergenP W Hellings
Laboratory of Experimental Immunology, Department of Internal Medicine, University Hospitals, Faculty of Medicine, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
Clin Exp Allergy 31:782-90. 2001..These findings support the viewpoint that upper and lower airway disease represent a continuum of inflammation involving one common airway and provide evidence for the concept of global airway inflammation after inhalation of allergen...
- Nasal provocation testing: a reviewL I Litvyakova
International Center of Interdisciplinary Studies of Immunology, Georgetown University, Washington, DC, USA
Ann Allergy Asthma Immunol 86:355-64; quiz 364-5, 386. 2001..Standardized nasal provocation testing has the potential to become a more frequently used clinical test in the diagnosis of allergic and occupational rhinitis and for determination of the appropriate and focused therapy...
- Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitisJeong Hoon Oh
Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
Allergy Asthma Proc 29:152-60. 2008..The aim of this study was to evaluate the role of locally produced allergen-specific antibodies in the nasal lavage fluid during the recruitment of inflammatory cells in AR...
- Nasal challenges with recombinant derivatives of the major birch pollen allergen Bet v 1 induce fewer symptoms and lower mediator release than rBet v 1 wild-type in patients with allergic rhinitisM van Hage-Hamsten
Department of Medicine, Division of Clinical Immunology, Karolinska Institute and Hospital, Stockholm, Sweden
Clin Exp Allergy 32:1448-53. 2002..Genetic engineering of the major birch pollen allergen (Bet v 1) has led to the generation of recombinant Bet v 1 derivatives with markedly reduced IgE-binding capacity, but with retained T cell activating ability...
- Statistical evaluation and parameters of phlogosis in patients sensitized to cypressM T Ventura
Department of Internal Medicine, Immunology and Infectious Disease MIDIM, University of Bari, Italy
J Biol Regul Homeost Agents 21:41-8. 2007..In addition, other allergo-immunologic parameters are evaluated in order to better evaluate this allergic phlogosis...
- Allergen-reactive antibodies are found in nasal fluids from patients with birch pollen-induced intermittent allergic rhinitis, but not in healthy controlsM Benson
Allergy Laboratory, Department of Oto-Rhino-Laryngology, , Malm, Sweden
Allergy 58:386-92. 2003..However, no significant differences were found between patients during and after the birch pollen season...
- Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitisMagnus Korsgren
Department of Clinical Pharmacology, University Hospital, SE 221 85 Lund, Sweden
Am J Respir Crit Care Med 167:1504-8. 2003..widespread occurrence in nasal mucosal nerves of patients with seasonal allergic rhinitis and that increased nasal lavage fluid levels of secretoneurin may characterize ongoing allergen exposure...
- Nasal neutrophil activity and mucinous secretory responsiveness in COPDUlf Nihlen
Departments of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 23:138-42. 2003..Furthermore, when associated with nasal symptoms, COPD may be associated with an increased nasal secretory responsiveness...
- Cytolysis of eosinophils in nasal secretionsKensuke Watanabe
Department of Otolaryngology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
Ann Otol Rhinol Laryngol 112:169-73. 2003....
- Effects of experimental changes in nasal airway pressure on mucosal output of plasmaSøren Berg
Department of Otorhinolaryngology, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 23:155-8. 2003..We conclude that extravasated plasma may be moved across the epithelium by a hydrostatic pressure-operated epithelial mechanism...
- Effects of intranasal TNFalpha on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitisHenrik Widegren
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
Respir Res 9:15. 2008..The objective of the present study was to examine indices of granulocyte presence and activity in response to intranasal TNFalpha challenge...
- Desloratadine reduces allergen challenge-induced mucinous secretion and plasma exudation in allergic rhinitisLennart Greiff
Department of Otorhinolaryngology, University Hospital, Lund, Sweden
Ann Allergy Asthma Immunol 89:413-8. 2002..The nasal output of fluid in allergic rhinitis is associated with luminal appearance of bioactive molecules emanating from the microcirculation as well as the secretory apparatus...
- Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposisG Di Lorenzo
Istituto di Medicina Interna e Geriatria, Dipartimento di Biopatologia e Metodologie Biomediche, Universita degli Studi di Palermo, Palermo, Italia
Int Arch Allergy Immunol 125:164-75. 2001..Polyp histology typically shows chronic, eosinophilic inflammation. The inflammatory cell infiltrate generally includes eosinophils, lymphocytes, plasma cells and mast cells...
- Effects of the inhalation of diesel exhaust, Kanto loam dust, or diesel exhaust without particles on immune responses in mice exposed to Japanese cedar (Cryptomeria japonica) pollenK Maejima
Energy and Environment Research Division, Japan Automobile Research Institute, 2530 Karima, Tsukuba shi, Ibaraki 305 0822, Japan
Inhal Toxicol 13:1047-63. 2001..Remarkable decrease of interferon-gamma and significant increase of interleukin-4 in the nasal lavage fluid were apparent after DE or DEG exposure, but not in the KLD group...
- Down-regulation of endogenous hydrogen sulphide pathway in nasal mucosa of allergic rhinitis in guinea pigsY Shaoqing
Department of Otolaryngology, Jinan General Hospital of PLA, Shandong, China
Allergol Immunopathol (Madr) 37:180-7. 2009..The present study was designed to explore the possible changes in endogenous hydrogen sulphide (H(2)S), a novel gasotransmitter, on the pathogenesis of allergic rhinitis (AR)...
- Differential responses to various classes of drugs in a model of allergic rhinitis in guinea pigsYousuf M Al Suleimani
Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Oman
Pulm Pharmacol Ther 21:340-8. 2008..anaesthetized animals, nasal airway pressure, pulmonary inflation pressure and cellular infiltration into nasal lavage fluid were measured...
- Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprintingBijar Ghafouri
Division of Occupational and Environmental Medicine, Linkoping University, Linkoping, Sweden
Proteomics 2:112-20. 2002..Changed levels of these proteins may therefore be of importance to the airway inflammation caused by smoking. The results also support the notion that PLUNC is involved in inflammatory responses in the upper airways...
- Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polypsAnju T Peters
Division of Allergy Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Allergy Clin Immunol 125:397-403.e10. 2010..Both the IL-6 receptor (IL-6R) and gp130 can be found in soluble forms that regulate the pathway...
- Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptionsMasum Shahriar
Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
J Immunol 183:2133-41. 2009..Provocation with TDI increased nasal symptoms, HDC activity, the histamine content of nasal lavage fluid, and the expression of H1R, HDC, and IL-4 mRNAs in TDI-sensitized rats...
- Exposure and nasal inflammation in workers heating polyurethaneMargareta Littorin
Department of Occupational and Environmental Medicine, University Hospital, 221 85 Lund, Sweden
Int Arch Occup Environ Health 75:468-74. 2002..To test the hypothesis that exposure to thermal-degradation products of polyurethane (PUR), particularly isocyanates, induced nasal inflammation...
- Controlled ethyl tert-butyl ether (ETBE) exposure of male volunteers. II. Acute effectsA Nihlen
Department of Occupational Medicine, National Institute for Working Life, Solna, Sweden
Toxicol Sci 46:143-50. 1998..and blinking frequency), nasal (acoustic rhinometry and analysis of inflammatory markers and cells in nasal lavage fluid), and pulmonary (peak expiratory flow, forced expiratory volume in 1 s, forced vital capacity, vital ..
- A comparison of biomarkers of ozone exposure in human plasma, nasal lavage, and sputumL Liu
Environmental Health Directorate, Health Canada, Ottawa, ON, Canada
Inhal Toxicol 11:657-74. 1999..and lower airway inflammatory responses and the concentrations of hydroxylated salicylate metabolites using nasal lavage fluid and induced sputum, in order to identify noninvasive and sensitive biomarkers for ozone exposure and effects...
- Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosaHideaki Shirasaki
Department of Otolaryngology, Sapporo Medical University, School of Medicine, Sapporo, Japan
Ann Allergy Asthma Immunol 102:110-5. 2009..been thought to be a potent mediator involved in allergic rhinitis because PGD2 has been recovered from the nasal lavage fluid of patients with allergic rhinitis after allergen provocation and because PGD2 receptor antagonists relieved ..
- Changes in the ocular and nasal signs and symptoms of aircrews in relation to the ban on smoking on intercontinental flightsG Wieslander
Department of Medical Sciences and Asthma Research Centre, Uppsala University, University Hospital, Sweden
Scand J Work Environ Health 26:514-22. 2000This study determined the influence of exposure to environmental tobacco smoke (ETS) in aircraft on measured and perceived cabin air quality (CAQ), symptoms, tear-film stability, nasal patency, and biomarkers in nasal lavage fluid.
- Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flightM Lindahl
Department of Health and Environment, Faculty of Health Sciences, Linkoping University, Sweden
Electrophoresis 22:1795-800. 2001We have analyzed protein patterns of human nasal lavage fluid (NLF) with two-dimensional gel electrophoresis (2-DE) and identified several proteins (such as transthyretin, Clara Cell protein 16, lipocalin-1, cystatin S, cystatin SN, ..
- INDIVIDUAL FACTORS IN NASAL IRRITANT SENSITIVITYDennis Shusterman; Fiscal Year: 2002..of mast cell degranulation (tryphase) and neuro-immune modulation (nerve growth factor) will be assayed in nasal lavage fluid pre- and post chemical provocation in a subset of subjects...
- PROTEOMICS COREJoseph Loo; Fiscal Year: 2006..responses and the role of phase II enzymes in allergic inflammation, (ii) characterize the proteome of human nasal lavage fluid to measure PM-induced oxidative stress responses in human subjects with high and low responses to DEP and to ..
- ENDOTOXIN AND BRONCHIAL INFLAMMATION IN ASTHMADavid Peden; Fiscal Year: 2001..airway responses of asthmatics who are responsive and non-responsive will be compared to baseline sputum and nasal lavage fluid IL-8 and ECP to determine if either in vitro monocyte responses or IL-8 and ECP in readily obtained airway ..
- Epidemiology of Dental Caries and Immunity in ChildrenNoel K Childers; Fiscal Year: 2010....
- Epidemiology of Dental Caries and Immunity in ChildrenNoel Childers; Fiscal Year: 2007....
- T Regulatory Cells and Childhood AsthmaJames Gern; Fiscal Year: 2007..abstract_text> ..
- Liposomal Recombinant Vaccine and Caries ImmunityNoel Childers; Fiscal Year: 2007....
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2007..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- Wisconsin Allergy & Immunology Research Training ProgramJames Gern; Fiscal Year: 2007..Given these opportunities, the WISCART program can continue to provide trainees with a comprehensive mentored research training experience that will prepare them for successful research careers in Allergy and Immunology. ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- Epidemiology of Dental Caries and Immunity in ChildrenNoel Childers; Fiscal Year: 2009....
- Reconstitution of Protective CMV Immunity and Immune Regulation After HAARTAdriana Weinberg; Fiscal Year: 2007..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. ..
- Epidemiology of Dental Caries and Immunity in ChildrenNoel Childers; Fiscal Year: 2009....
- AADRC -- Mechanisms of Virus-Induced AsthmaJames Gern; Fiscal Year: 2005..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
- RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITISFuad Baroody; Fiscal Year: 2003..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
- MECHANISMS OF RHINITIS IN CFSJames Baraniuk; Fiscal Year: 1999..e. nasal provocation) as the means to evaluate future treatments of CFS. ..
- LIPOSOMAL S MUTANS DELIVERY SYSTEM FOR CARIES IMMUNITYNoel Childers; Fiscal Year: 2001....
- PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN ADavid Briles; Fiscal Year: 1993....
- Routes of prion neuroinvasion following oral infectionRICHARD BESSEN; Fiscal Year: 2006....
- PspA: A Potential Pneumococcal Vaccine ComponentDavid Briles; Fiscal Year: 2009..pneumoniae is important because of the high complexity and cost of the polysaccharide-protein conjugate vaccine and the rapid evolution of pneumococci to evade the capsule-type-specific protection elicited by the conjugate vaccine. ..
- Regulation of ENaC by Serine Proteases in AirwaysScott Donaldson; Fiscal Year: 2006..The PI's long term goals are to provide important new insights into the basic elements of airway defense, CF lung disease, and to bring these findings to the development of novel therapies for CF lung disease. ..
- Lifecourse SES and Cardiovascular Disease RiskDENISE DEVERTS; Fiscal Year: 2009....
- Social and psychological risk for infectious illnessSheldon Cohen; Fiscal Year: 2009..abstract_text> ..
- Human Metapneumovirus Infections in ChildrenJohn Williams; Fiscal Year: 2004..The specific aims of this study are to define the prevalence of hMPV infection in children, describe fully the spectrum of clinical illness and identify serologic markers of seroconversion and correlates of immunity. ..
- IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A AND CDavid Briles; Fiscal Year: 2002..The data obtained will assist with the development of correlates of protective immunity for PspA and PspC that can be applied to vaccine development. ..
- Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in AfricaJeffrey Martin; Fiscal Year: 2007..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
- Environmental Determinants of Pulmonary Disease: A new approach to an old problemErik Svendsen; Fiscal Year: 2007..Objective: Increase public and professional preparedness for chemical/radiological disasters). ..