nasal lavage fluid

Summary

Summary: Fluid obtained by irrigation or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.

Top Publications

  1. ncbi Nerve growth factor expression and release in allergic inflammatory disease of the upper airways
    A M Sanico
    Department of Medicine, Division of Clinical Immunology, and Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 161:1631-5. 2000
  2. ncbi Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study
    Giorgio Ciprandi
    Allergologia U O ORL, Dipartimento Regionale Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, 16132, Genoa, Italy
    Int Immunopharmacol 5:1800-8. 2005
  3. doi Nasal challenge with LPS stimulates the release of macrophage inflammatory protein 1alpha
    Anna Karin Ekman
    Division of ENT Diseases Huddinge, Karolinska Institute, Stockholm, Sweden
    Int Arch Allergy Immunol 149:154-60. 2009
  4. ncbi Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life
    D James Nokes
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    J Infect Dis 190:1828-32. 2004
  5. ncbi Nasal polyps in cystic fibrosis: clinical endoscopic study with nasal lavage fluid analysis
    Gert Henriksson
    Department of Otolaryngology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Chest 121:40-7. 2002
  6. ncbi Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus
    M L Herlocher
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Infect Dis 184:542-6. 2001
  7. doi Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients
    A Fuentes-Beltrán
    Department of Immunogenetics and Allergy, Instituto Nacional de Enfermedades Respiratorias, Calzada Tlalpan, Mexico
    Clin Exp Allergy 39:491-9. 2009
  8. pmc Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis
    David D Tieu
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill 60607, USA
    J Allergy Clin Immunol 125:667-75. 2010
  9. ncbi Pituitary adenylate cyclase-activating polypeptide, effects in the human nose
    J Kinhult
    Laboratory for Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Clin Exp Allergy 33:942-9. 2003
  10. doi Effect of histamine H4 receptor antagonist on allergic rhinitis in mice
    Yuji Takahashi
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima naka 1 1 1, Okayama 700 8530, Japan
    Int Immunopharmacol 9:734-8. 2009

Research Grants

  1. INDIVIDUAL FACTORS IN NASAL IRRITANT SENSITIVITY
    Dennis Shusterman; Fiscal Year: 2002
  2. ENDOTOXIN AND BRONCHIAL INFLAMMATION IN ASTHMA
    David Peden; Fiscal Year: 2001
  3. PROTEOMICS CORE
    Joseph Loo; Fiscal Year: 2006
  4. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
  5. Social and psychological risk for infectious illness
    Sheldon Cohen; Fiscal Year: 2007
  6. Social and psychological risk for infectious illness
    Sheldon A Cohen; Fiscal Year: 2010
  7. Social and psychological risk for infectious illness
    Sheldon Cohen; Fiscal Year: 2009
  8. Epidemiology of Dental Caries and Immunity in Children
    Noel Childers; Fiscal Year: 2007
  9. Epidemiology of Dental Caries and Immunity in Children
    Noel Childers; Fiscal Year: 2009
  10. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2007

Detail Information

Publications210 found, 100 shown here

  1. ncbi Nerve growth factor expression and release in allergic inflammatory disease of the upper airways
    A M Sanico
    Department of Medicine, Division of Clinical Immunology, and Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 161:1631-5. 2000
    ....
  2. ncbi Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study
    Giorgio Ciprandi
    Allergologia U O ORL, Dipartimento Regionale Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, 16132, Genoa, Italy
    Int Immunopharmacol 5:1800-8. 2005
    ..Nasal obstruction is the main symptom in patients with perennial allergic rhinitis. Some new antihistamines have been demonstrated to be capable of improving this symptom...
  3. doi Nasal challenge with LPS stimulates the release of macrophage inflammatory protein 1alpha
    Anna Karin Ekman
    Division of ENT Diseases Huddinge, Karolinska Institute, Stockholm, Sweden
    Int Arch Allergy Immunol 149:154-60. 2009
    ..Macrophage inflammatory protein 1alpha (MIP-1alpha) is a chemokine released during the inflammatory process. The present study investigated the potential role and regulation of MIP-1alpha in LPS-induced nasal inflammation...
  4. ncbi Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life
    D James Nokes
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    J Infect Dis 190:1828-32. 2004
    ..RSV contributed significantly to total LRTI disease in this vaccine-target group...
  5. ncbi Nasal polyps in cystic fibrosis: clinical endoscopic study with nasal lavage fluid analysis
    Gert Henriksson
    Department of Otolaryngology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Chest 121:40-7. 2002
    ..The aims of this study were to focus on what problems (symptoms, endoscopic findings, and laboratory correlates) nasal polyps cause the CF patient, and how these correlate to the total health situation of this patient group...
  6. ncbi Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus
    M L Herlocher
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Infect Dis 184:542-6. 2001
    ..The results show the value of the ferret model. A/LA resembled the transmission of influenza in humans when under antibody pressure...
  7. doi Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients
    A Fuentes-Beltrán
    Department of Immunogenetics and Allergy, Instituto Nacional de Enfermedades Respiratorias, Calzada Tlalpan, Mexico
    Clin Exp Allergy 39:491-9. 2009
    ..Airway eosinophilia is a hallmark of aspirin-sensitive asthma/rhinitis...
  8. pmc Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis
    David D Tieu
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill 60607, USA
    J Allergy Clin Immunol 125:667-75. 2010
    ..Decreased epithelial expression of mRNA for S100A7 (psoriasin) and S100A8/A9 (calprotectin) has been reported in patients with chronic rhinosinusitis (CRS)...
  9. ncbi Pituitary adenylate cyclase-activating polypeptide, effects in the human nose
    J Kinhult
    Laboratory for Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Clin Exp Allergy 33:942-9. 2003
    ....
  10. doi Effect of histamine H4 receptor antagonist on allergic rhinitis in mice
    Yuji Takahashi
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima naka 1 1 1, Okayama 700 8530, Japan
    Int Immunopharmacol 9:734-8. 2009
    ..We measured allergic symptoms (sneezing and nasal rubbing), serum total IgE and the levels of cytokines in nasal lavage fluid. Histamine H(4) receptor antagonist, JNJ7777120, caused the dose-dependent inhibition of nasal symptoms by ..
  11. ncbi Nasal lavage fluid and proteomics as means to identify the effects of the irritating epoxy chemical dimethylbenzylamine
    Mats Lindahl
    Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Biomarkers 9:56-70. 2004
    The aims of this study were to describe the changes in the nasal lavage fluid (NLF) protein pattern after exposure to the irritating epoxy chemical dimethylbenzylamine (DMBA) and to identify the affected proteins using a proteomic ..
  12. pmc Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study
    G Rohde
    University Hospital Bergmannsheil, Department of Internal Medicine, Division of Pneumology, Allergology and Sleep Medicine, D 44789 Bochum, Germany
    Thorax 58:37-42. 2003
    ..Many exacerbations are believed to be due to upper and/or lower respiratory tract viral infections, but the incidence of these infections in patients with COPD is still undetermined...
  13. ncbi Relationships among bacteria, upper airway, lower airway, and systemic inflammation in COPD
    John R Hurst
    Academic Unit of Respiratory Medicine, Dominion House, St Bartholomew s Hospital, London, EC1A 7BE, UK
    Chest 127:1219-26. 2005
    ....
  14. ncbi Demonstration of different forms of the anti-inflammatory proteins lipocortin-1 and Clara cell protein-16 in human nasal and bronchoalveolar lavage fluids
    M Lindahl
    Department of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
    Electrophoresis 20:881-90. 1999
    ..Furthermore, the identification of different forms of the two proteins makes possible more detailed studies on the role of these proteins in inflammatory disease processes and anti-inflammatory therapies...
  15. ncbi Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge
    E M Erin
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Clin Exp Allergy 35:1608-14. 2005
    ..Cytokines and chemokines produced by allergen-reactive T-helper type 2 (Th2) cells may be pivotal to the pathophysiology of allergic disorders...
  16. ncbi Repeatability and validity of cell and fluid-phase measurements in nasal fluid: a comparison of two methods of nasal lavage
    J Belda
    Asthma Research Group, Department of Medicine, St Joseph's Hospital and McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Clin Exp Allergy 31:1111-5. 2001
    ..In subjects with rhinitis, although the repeatability of eosinophil counts is similar by both methods, the modified Greiff/Grunberg method gives more reproducible ECP measurements, compared with the Naclerio method...
  17. doi Nasal CpG oligodeoxynucleotide administration induces a local inflammatory response in nonallergic individuals
    A Mansson
    Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Sweden
    Allergy 64:1292-300. 2009
    ..CpG is known to skew the immune system towards a T helper 1 (Th1) profile, thereby suppressing Th2-driven allergic responses. This study was designed to examine the effects of CpG administration in the human nose...
  18. pmc Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren
    Albino Barraza-Villarreal
    Instituto Nacional de Salud Publica, Cuernavaca, Mexico
    Environ Health Perspect 116:832-8. 2008
    ..The biological mechanisms involved in inflammatory response to air pollution are not clearly understood...
  19. ncbi Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigs
    K Miyake
    Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Sizuoka, Japan
    Jpn J Pharmacol 85:453-6. 2001
    ..of allergic rhinitis, we determined its effects on the increase of chemical mediator concentrations in nasal lavage fluid following the intranasal antigen challenge in guinea pigs actively sensitized with DNP-Ascaris...
  20. ncbi Traffic-related air pollution affects peak expiratory flow, exhaled nitric oxide, and inflammatory nasal markers
    P A Steerenberg
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Arch Environ Health 56:167-74. 2001
    ..In summary, urban children had increased levels of inflammatory nasal markers, and their responses were more pronounced than were the suburban children's responses to the same increments of air pollution...
  21. ncbi Steroid-sensitive indices of airway inflammation in children with seasonal allergic rhinitis
    Peter Meyer
    Department of Pediatrics, University Hospital, Lund, Sweden
    Pediatr Allergy Immunol 14:60-5. 2003
    ..i.d) were determined in children with seasonal allergic rhinitis. Nasal lavage fluid levels of eotaxin, eosinophil cationic protein (ECP), and alpha2-macroglobulin, indicating plasma exudation, ..
  22. ncbi Occupational asthma and rhinitis due to glutaraldehyde: changes in nasal lavage fluid after specific inhalatory challenge test
    C Pałczyński
    Department of Occupational Diseases, Centre of Occupational and Environmental Allergy, Nofer Institute of Occupational Medicine, 8 Sw Teresy Street, 90 950 Łódź, Poland
    Allergy 56:1186-91. 2001
    ..Specific changes in nasal lavage fluid (NLF) induced by high-molecular-weight allergen provocation in sensitized subjects were described previously...
  23. ncbi Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease
    John R Hurst
    F R C P, Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Royal Free Hospital London NW3 2PF UK
    Am J Respir Crit Care Med 173:71-8. 2006
    ..Although exacerbations of COPD are associated with increased pulmonary and systemic inflammation, determinants of the systemic response remain obscure, and nor is it known whether there is nasal involvement...
  24. doi Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnel
    Britt Marie Larsson
    Department of Public Health Sciences, Division of Occupational and Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Med 104:1912-8. 2010
    ..Our findings may further emphasize asthmatics as a vulnerable group to common air pollutants...
  25. pmc Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids
    Violetta M Piotrowska
    Department of Pediatric Otolaryngology, Medical University of Lodz, Poland
    Int J Chron Obstruct Pulmon Dis 5:107-17. 2010
    ..We provide evidence of upper airways disease in COPD, which appears to be related more to patients who currently smoke than to disease severity...
  26. ncbi Nasal and ocular symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-dampness and building design in hospitals
    G Wieslander
    Department of Medical Sciences, Department of Occupational and Environmental Medicine, University Hospital, Uppsala University, S 751 85, Uppsala, Sweden
    Int Arch Occup Environ Health 72:451-61. 1999
    ..To study the relationships between dampness in concrete floors and building design on the one hand, and symptoms and medical signs of the eyes and nose in hospital workers, on the other...
  27. doi A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis
    H Wang
    The Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden
    Allergy 66:132-40. 2011
    ..In this study, we aimed to identify (i) pathways affected by local GC treatment and (ii) examine if those pathways could be used to find novel markers of local GC treatment in nasal fluids from patients with IAR...
  28. ncbi Expression of ICAM-1 in nasal epithelium and levels of soluble ICAM-1 in nasal lavage fluid during human experimental rhinovirus infection
    Birgit Winther
    University of Virginia Health System, Department of Internal Medicine, Box 800473, Charlottesville, VA 22908, USA
    Arch Otolaryngol Head Neck Surg 128:131-6. 2002
    ..examined with immunohistochemical staining of nasal scrape biopsy specimens, and levels of soluble ICAM-1 in nasal lavage fluid were measured by sandwich enzyme-linked immunosorbent assay technique...
  29. ncbi Aspergillus fumigatus challenge increases cytokine levels in nasal lavage fluid
    H Stark
    Department of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland
    Inhal Toxicol 18:1033-9. 2006
    ..levels (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, IL-4, IL-6, interferon [IFN]-gamma) in nasal lavage fluid (NAL) compared with that evoked by placebo challenge...
  30. doi [Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]
    Radosław Gawlik
    Katedra i Klinika Chorob Wewnetrznych, Alergologii i Immunologii Klinicznej Slaskiego Uniwersytetu Medycznego w Katowicach
    Otolaryngol Pol 61:567-71. 2007
    ..Increase in concentration of endothelin-1 in nasal lavage fluid from allergic patients were significantly higher than in control group respectively from 18.33 +/- 5...
  31. ncbi PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid
    B Ghafouri
    Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Biochem Soc Trans 31:810-4. 2003
    ..We have identified two forms of the PLUNC protein in human nasal lavage fluid (NLF) using two-dimensional gel electrophoresis (2-DE) and MS...
  32. ncbi PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide
    Bijar Ghafouri
    Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Biochim Biophys Acta 1699:57-63. 2004
    Here, we demonstrate the presence of multiple isoforms of palate lung nasal epithelial clone (PLUNC) in human nasal lavage fluid (NLF)...
  33. ncbi Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study
    Monika Raulf-Heimsoth
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Institut der Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Arch Toxicol 81:35-44. 2007
    ..Humoral and cellular parameters were measured in nasal lavage fluid (NALF) and induced sputum...
  34. pmc Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometry
    Malin Bryborn
    Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Respir Res 6:118. 2005
    ..DNA microarrays have recently made it possible to compare mRNA profiles of lavage fluids from healthy and diseased patients, whereas information on the protein level is still lacking...
  35. pmc Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients
    Linda M Benson
    Mayo Proteomics Research Center, Mayo Clinic, Rochester, MN, USA
    J Sep Sci 32:44-56. 2009
    ..To enhance the detection of lower abundance proteins, intact nasal lavage fluid (NLF) proteins from nonpolypoid AR and from asthmatic CRS patients were extensively fractionated prior to LC/..
  36. ncbi Effects of TNFalpha on the human nasal mucosa in vivo
    Henrik Widegren
    Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
    Respir Med 101:1982-7. 2007
    ..Increased nasal mucosal output of TNFalpha has been demonstrated in allergic rhinitis, but the effect of TNFalpha on the human nasal mucosa has not been examined in vivo...
  37. ncbi The kinetics of allergen-induced eotaxin level in nasal lavage fluid: its key role in eosinophil recruitment in nasal mucosa
    N Terada
    Department of Otorhinolaryngology, Chiba University School of Medicine, Chiba, Japan
    Am J Respir Crit Care Med 164:575-9. 2001
    ..challenge led to parallel increases in eosinophil counts, levels of EPX, and eotaxin concentrations in nasal lavage fluid. The levels of eotaxin in lavage samples showed strong correlation with lavage levels of eosinophil counts ..
  38. ncbi Measuring plasma exudation in nasal lavage fluid and in induced sputum as a tool for studying respiratory tract inflammation
    D A van Zuijlen
    Department of Otorhinolaryngology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    J Immunol Methods 256:1-10. 2001
    ..Determination of plasma exudation together with RCE in NAL and induced sputum is a good, non-invasive way to quantify inflammation of airway mucosa...
  39. ncbi Changes of symptoms, tear film stability and eosinophilic cationic protein in nasal lavage fluid after re-exposure to a damp office building with a history of flooding
    G Wieslander
    Department of Medical Sciences, Uppsala University and University Hospital, Uppsala, Sweden
    Indoor Air 17:19-27. 2007
    ..In conclusion, subjects previously exposed to building dampness had an increase of symptoms, reduced tear film stability, and signs of eosinophilic inflammation in the nasal mucosa after 2 days of re-exposure...
  40. ncbi Nasal lavage fluid examination and rhinomanometry in the diagnostics of occupational airway allergy to laboratory animals
    Anna Krakowiak
    Department of Occupational Diseases, Nofer Institute of Occupational Medicine, Lodz, Poland
    Int J Occup Med Environ Health 16:125-32. 2003
    The purpose of this studywas to compare the cellular and biochemical findings in the nasal lavage fluid (NALF) and nasal resistance changes due to a challenge with laboratory animal allergens in 25 patients with occupational asthma and ..
  41. ncbi Comparative proteomics of nasal fluid in seasonal allergic rhinitis
    B Ghafouri
    Division of Occupational and Environmental Medicine, Department of Molecular and Clinical Medicine, Linkoping University, Sweden
    J Proteome Res 5:330-8. 2006
    A comparative proteomic approach was applied to examine nasal lavage fluid (NLF) from patients with seasonal allergic rhinitis (SAR, n = 6) and healthy subjects (controls, n = 5)...
  42. ncbi TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis
    P Bradding
    Immunopharmacology Group, Southampton University, UK
    Clin Exp Allergy 25:406-15. 1995
    ..05). This difference was also apparent when studying the area under the curve both at 30 and 60 min post-challenge t-test (P = 0.015 and 0.02 respectively).(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi Gene profiling reveals decreased expression of uteroglobin and other anti-inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis
    M Benson
    Laboratory for Clinical and Experimental Allergy Research, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
    Clin Exp Allergy 35:473-8. 2005
    ..Little is known about anti-inflammatory mediators in IAR. DNA microarrays allow simultaneous analysis of the whole transcriptome in a sample...
  44. ncbi Circulating neutrophil CD14 expression and the inverse association of ambient particulate matter on lung function in asthmatic children
    Erik R Svendsen
    Office of Research and Development, EPA, Research Triangle Park, North Carolina 29208, USA
    Ann Allergy Asthma Immunol 99:244-53. 2007
    ....
  45. ncbi Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry
    Begona Casado
    Division of Rheumatology, Georgetown University, Washington, DC, USA
    Electrophoresis 25:1386-93. 2004
    ..The proteomic approach presented here allowed us to identify, in the high complexity of acute sinusitis nasal secretions, the proteins that respond to a pharmacological treatment and that could be suitable as markers of this pathology...
  46. ncbi Eosinophilia and cell activation mediators in nasal secretions
    Clotilde Besançon-Watelet
    Laboratoire d Immunologie du CHU, Faculte de Medecine, 54505, Vandoeuvre les Nancy Cedex, France
    Laryngoscope 112:43-6. 2002
    ..We assayed the levels of these three molecules in nasal secretions in correlation with cytologic findings and especially the degree of eosinophilia...
  47. ncbi Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin
    You Sook Cho
    Division of Allergy and Rheumatology, Department of Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    J Allergy Clin Immunol 112:695-701. 2003
    ..The exact mechanism of a chronic nonproductive cough is sometimes unclear when patients who are without symptoms or signs indicating the major causes of chronic cough remain undiagnosed...
  48. ncbi Nitric oxide and proinflammatory cytokines in nasal lavage fluid associated with symptoms and exposure to moldy building microbes
    M R Hirvonen
    Division of Environmental Health, National Public Health Institute, Kuopio, Finland
    Am J Respir Crit Care Med 160:1943-6. 1999
    ..concentrations of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and nitric oxide (NO) in nasal lavage fluid were significantly higher in the exposed than in the control subjects at the end of the first exposure ..
  49. ncbi Protein patterns of human nasal and bronchoalveolar lavage fluids analyzed with two-dimensional gel electrophoresis
    M Lindahl
    Department of Health and Environment, Faculty of Health Sciences, University of Linkoping, Sweden
    Electrophoresis 19:3222-9. 1998
    We have previously described the protein patterns of human nasal lavage fluid (NLF) and bronchoalveolar lavage fluid (BALF) after two-dimensional gel electrophoresis (2-DE)...
  50. ncbi Interleukin-5 and interleukin-8 in relation to eosinophils and neutrophils in nasal fluids from school children with seasonal allergic rhinitis
    M Benson
    Department of Pediatrics, Sahlgrenska University Hospital, Goteborg, Sweden
    Pediatr Allergy Immunol 10:178-85. 1999
    ..IL-5 levels and relative eosinophil counts in nasal lavage fluid increased significantly in patients with allergic rhinitis during the pollen season, compared with values ..
  51. ncbi Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis
    Ji Hun Mo
    Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
    Am J Rhinol 20:212-8. 2006
    ..Der f is the most common allergen-inducing allergic rhinitis in Korea...
  52. ncbi Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis
    Yu Zhao
    Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Ann Allergy Asthma Immunol 96:844-50. 2006
    ..Jia Wei Cang Er Zi San, a traditional Chinese herbal formula, has been used to treat allergic rhinitis (AR) for several centuries. However, its effect on experimental animal models and its therapeutic mechanism remain unclear...
  53. ncbi Time-dependent observations of secretion marker levels in nasal secretion after histamine and methacholine provocations
    Małgorzata Pupek
    Department of Chemistry and Immunochemistry, Wrocław Medical University, Bujwida 44a, 50 345 Wrocław, Poland
    Arch Immunol Ther Exp (Warsz) 51:259-65. 2003
    ..These observations suggest a time- and dose-dependent, non-specific dysfunction of local immunity response after nasal provocations...
  54. ncbi Evaluation of nasal barrier dysfunction at acute- and late-phase reactions in a guinea pig model of allergic rhinitis
    Sofia Elovsson
    Department of Clinical Study Management, AstraZeneca R and D Lund, Sweden
    Vascul Pharmacol 43:267-76. 2005
    ..We suggest that this model of guinea pig allergic rhinitis with the early and late responses may be useful for high-throughout screening of new drugs...
  55. ncbi Epithelial shedding is associated with nasal reactions to cold, dry air
    Alvaro A Cruz
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 117:1351-8. 2006
    ..One hypothesis is that the respiratory mucosa of individuals with CDA sensitivity cannot compensate for the loss of water that occurs on exposure to the stimulus, leading to epithelial damage...
  56. ncbi Elevations of local leukotriene C4 levels during viral upper respiratory tract infections
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:270-4. 2003
    ..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
  57. ncbi Collection of nasal secretions for immunological analysis
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Eur Arch Otorhinolaryngol 261:242-6. 2004
    ..The method is non-invasive, well standardized and reproducible and therefore may serve as a valid tool for future investigations...
  58. ncbi Characteristics of eosinophils migrating around fungal hyphae in nasal discharge
    Kensuke Watanabe
    Department of Otorhinolaryngology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Ann Otol Rhinol Laryngol 113:200-4. 2004
    ..This structure detected in eosinophils has not been reported previously, and is considered to be an interesting finding from the viewpoint of the function of eosinophils...
  59. ncbi Effects of intranasal fluticasone and salmeterol on allergen-induced nasal responses
    K Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, and Department of Medicine, McMaster University, Hamilton, Canada
    Allergy 61:731-6. 2006
    ..Combination of inhaled steroid and long-acting beta-agonists has synergistic effects in asthma...
  60. ncbi Bet v 1-specific IgA increases during the pollen season but not after a single allergen challenge in children with birch pollen-induced intermittent allergic rhinitis
    Christina Keen
    Department of Pediatrics, Goteborg University, Queen Silvia Children s Hospital, Goteborg, Sweden
    Pediatr Allergy Immunol 16:209-16. 2005
    ..These findings are compatible with the hypothesis that allergen-specific IgA plays a role in the allergic inflammation and further studies are needed to clarify the functional role of these allergen-specific antibodies...
  61. ncbi Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis
    Anna Wedbäck
    Lung and Allergy Clinic, County Hospital, Halmstad, Sweden
    Rhinology 43:86-92. 2005
    ..SNAR seems to be different from SAR and PNAR regarding immunological mechanism and symptom period. We conclude that the cause of SNAR is unknown...
  62. ncbi Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge
    E M Erin
    National Heart and Lung Institute NHLI Clinical Studies Unit, Imperial College, London, UK
    Allergy 60:1524-9. 2005
    ..Objective: To determine the effects of a single dose of topical steroid on eosinophils and levels of chemokines and cytokines in nasal lavage fluid following NAC in patients with allergic rhinitis.
  63. ncbi Changes in airway inflammation following nasal allergic challenge in patients with seasonal rhinitis
    M Bonay
    Unité 700 INSERM, Faculte Xavier Bichat, Paris Cedex, France
    Allergy 61:111-8. 2006
    ..The aim of this study was to analyse the changes induced by allergic nasal challenge outside the pollen season in airway responsiveness and bronchial inflammation of patients with seasonal allergic rhinitis...
  64. ncbi Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure
    C A Ahlstrom-Emanuelsson
    Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, 221 84 Lund, Sweden
    Eur Respir J 24:750-7. 2004
    ..Furthermore, nasal lavage fluid levels of eosinophil cationic protein (ECP) and alpha2-macroglobulin were assessed as indices of eosinophil ..
  65. ncbi Stronger nasal responsiveness to cold air in individuals with rhinitis and asthma, compared with rhinitis alone
    L S Hanes
    Department of Pediatrics, Children s Hospital of New York Presbyterian, Columbia University, NewYork, NY, USA
    Clin Exp Allergy 36:26-31. 2006
    ..Objective To test the hypothesis that, a previously well-studied natural nasal stimulus, cold, dry air (CDA), produces a stronger response in subjects with allergic rhinitis (AR) and asthma compared with subjects with AR alone...
  66. ncbi Neuropathology in rhinosinusitis
    James N Baraniuk
    Division of Rheumatology, Immunology and Allergy, Georgetown University, 3800 Reservoir Road, N W, Washington, DC 20007 2197, USA
    Am J Respir Crit Care Med 171:5-11. 2005
    ..CFS had neural hypersensitivity (pain) but reduced serous cell secretion. HTS nasal provocations identified significant, unique patterns of neural and mucosal dysregulation in each rhinosinusitis syndrome...
  67. ncbi Does nitrogen dioxide affect inflammatory markers after nasal allergen challenge?
    Charlotte Barck
    Division of Respiratory Medicine and Allergology, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Rhinol 19:560-6. 2005
    ..Exposure to high ambient levels of nitrogen dioxide (NO2) enhances the bronchial inflammatory reaction to allergen in humans. We tested whether this NO2 effect occurs also in the upper airways...
  68. ncbi Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis
    G Ciprandi
    Allergy and ENT Division, Head Neck Dpt, San Martino Hospital, Genoa
    Eur Ann Allergy Clin Immunol 36:237-40. 2004
    ..007). This study shows the cetirizine effectiveness in exerting anti-inflammatory activity by modulating cytokine pattern and by reducing inflammatory infiltration in children with perennial allergic rhinitis...
  69. ncbi A role for neutrophils in intermittent allergic rhinitis
    Mattias Fransson
    Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Acta Otolaryngol 124:616-20. 2004
    ..The aim of this study was to examine the correlation between inflammatory cells in the nasal lavage fluid and clinical parameters following pollen challenge.
  70. ncbi Airway function and nasal inflammation in seasonal allergic rhinitis and asthma
    G Ciprandi
    Ospedale San Martino, Genoa, Italy
    Clin Exp Allergy 34:891-6. 2004
    ..Allergic rhinitis (AR) and asthma are frequently associated and characterized by a Th2-dependent inflammation. Nasal and bronchial obstruction may be objectively measured...
  71. ncbi Composition of nasal airway surface liquid in cystic fibrosis and other airway diseases determined by X-ray microanalysis
    V Vanthanouvong
    Department of Medical Cell Biology, University of Uppsala, and Cystic Fibrosis Center, Uppsala University Hospital, Uppsala, Sweden
    Microsc Res Tech 69:271-6. 2006
    ....
  72. ncbi Inflammatory profile in nasal secretions of infants hospitalized with acute lower airway tract infections
    Paulo M C Pitrez
    Division of Clinical Sciences, Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia
    Respirology 10:365-70. 2005
    ..The aim of this study was to determine whether the regulatory immune response (interleukin (IL)-10 response) differed between children hospitalized with acute respiratory infections and wheezing...
  73. ncbi [Myeloperoxidase (MPO) as a marker of neutrophil influx into nasal mucosa after recombinant IL-8 challenge]
    Maciej Kupczyk
    Klinika Pneumonologii i Alergologii IMW AM w Łodzi
    Pneumonol Alergol Pol 70:544-9. 2002
    ..258, p = 0.42). Due to the lack of statistically confirmed relationship between MPO level and the number of neutrophils, MPO seems to be of little value as a marker of neutrophil influx into nasal mucosa...
  74. ncbi The effect of recombinant interleukin-8 on eosinophils' and neutrophils' migration in vivo and in vitro
    M Bocheńska-Marciniak
    Department of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland
    Allergy 58:795-801. 2003
    ..The objective of this study was to investigate the effect of nasal instillation of IL-8 on the influx of inflammatory cells...
  75. ncbi Swine dust exposure is a model for rapid induction of non-allergic neutrophil inflammation in the nasal mucosa of healthy volunteers, and the symptoms as well as the microcirculation are modified by nasal lavage
    Anders Ehnhage
    Department of Clinic Sience, Intervention an Technology, Division of Otorhinolaryngology, Karolinska Institutet, Huddinge, Stockholm, Sweden
    Rhinology 45:292-8. 2007
    ..In this study the aim was to investigate the effects of swine dust exposure on nasal symptoms as well as the microcirculation. Furthermore, the effect on nasal lavage was investigated...
  76. ncbi No involvement of interleukin-5 or eosinophils in experimental allergic rhinitis in guinea pigs
    Masashi Yamasaki
    Department of Pharmacology, Kyoto Pharmaceutical University, 5 Nakauchi, Misasagi, Yamashina, 607 8414, Kyoto, Japan
    Eur J Pharmacol 439:159-69. 2002
    ....
  77. ncbi Statistical evaluation and parameters of phlogosis in patients sensitized to cypress
    M T Ventura
    Department of Internal Medicine, Immunology and Infectious Disease MIDIM, University of Bari, Italy
    J Biol Regul Homeost Agents 21:41-8. 2007
    ..In addition, other allergo-immunologic parameters are evaluated in order to better evaluate this allergic phlogosis...
  78. ncbi Nasal and otologic effects of experimental respiratory syncytial virus infection in adults
    Craig A Buchman
    Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Am J Otolaryngol 23:70-5. 2002
    ..This study was conducted to more clearly define the extent and frequency of nasal and otologic effects of respiratory syncytial virus infection in healthy adult volunteers...
  79. pmc Effects of intranasal TNFalpha on granulocyte recruitment and activity in healthy subjects and patients with allergic rhinitis
    Henrik Widegren
    Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden
    Respir Res 9:15. 2008
    ..The objective of the present study was to examine indices of granulocyte presence and activity in response to intranasal TNFalpha challenge...
  80. ncbi Hot, humid air increases cellular influx during the late-phase response to nasal challenge with antigen
    P Assanasen
    The Section of Otolaryngology-Head and Neck Surgery, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Clin Exp Allergy 31:1913-22. 2001
    ..Increasing eosinophil number had no effects on the hyper-responsiveness to histamine. We speculate that the physical conditions of air differentially impact the stages of allergic inflammation...
  81. doi Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitis
    Jeong Hoon Oh
    Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Allergy Asthma Proc 29:152-60. 2008
    ..The aim of this study was to evaluate the role of locally produced allergen-specific antibodies in the nasal lavage fluid during the recruitment of inflammatory cells in AR...
  82. ncbi Superiority of an intranasal corticosteroid compared with an oral antihistamine in the as-needed treatment of seasonal allergic rhinitis
    S M Kaszuba
    Section of Otolaryngology-Head and Neck Surgery, University of Chicago, 5841 S Maryland Ave, Mail Code 1035, Chicago, IL 60637, USA
    Arch Intern Med 161:2581-7. 2001
    ..70, P<.01). CONCLUSION: As-needed intranasal corticosteroids reduce allergic inflammation and are more effective than as-needed H(1) receptor antagonists in the treatment of seasonal allergic rhinitis...
  83. doi Vascular endothelial growth factor produced in nasal glands of perennial allergic rhinitis
    Shoji Matsune
    Department of Otolaryngology, Head and Neck Surgery, Field of Sensory Organology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Am J Rhinol 22:365-70. 2008
    ..This study was designed to investigate and discuss the pathophysiological significance of VEGF in nasal secretions from perennial allergic rhinitis sufferers...
  84. ncbi Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper-reactivity in sensitized mice exposed to aerosolized allergen
    P W Hellings
    Laboratory of Experimental Immunology, Department of Internal Medicine, University Hospitals, Faculty of Medicine, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Clin Exp Allergy 31:782-90. 2001
    ..These findings support the viewpoint that upper and lower airway disease represent a continuum of inflammation involving one common airway and provide evidence for the concept of global airway inflammation after inhalation of allergen...
  85. ncbi Nasal provocation testing: a review
    L I Litvyakova
    International Center of Interdisciplinary Studies of Immunology, Georgetown University, Washington, DC, USA
    Ann Allergy Asthma Immunol 86:355-64; quiz 364-5, 386. 2001
    ..Standardized nasal provocation testing has the potential to become a more frequently used clinical test in the diagnosis of allergic and occupational rhinitis and for determination of the appropriate and focused therapy...
  86. ncbi Hypertonic saline nasal provocation and acoustic rhinometry
    J N Baraniuk
    Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC 20007, USA
    Clin Exp Allergy 32:543-50. 2002
    ..Hypertonic saline (HTS) acts as an airway irritant in human nasal mucosa by stimulating nociceptive nerves and glandular secretion. HTS does not change vascular permeability. In asthma, HTS causes airflow obstruction...
  87. ncbi DNA microarray analysis of transforming growth factor-beta and related transcripts in nasal biopsies from patients with allergic rhinitis
    Mikael Benson
    Allergy Laboratory, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
    Cytokine 18:20-5. 2002
    ..Low expression of TGF-beta-inducible transcripts may indicate decreased TGF-beta activity in allergic rhinitis. DNA microarray analysis may be a way to study cytokine effects in vivo...
  88. ncbi Effects of experimental changes in nasal airway pressure on mucosal output of plasma
    Søren Berg
    Department of Otorhinolaryngology, University Hospital, Lund, Sweden
    Clin Physiol Funct Imaging 23:155-8. 2003
    ..We conclude that extravasated plasma may be moved across the epithelium by a hydrostatic pressure-operated epithelial mechanism...
  89. ncbi Nasal neutrophil activity and mucinous secretory responsiveness in COPD
    Ulf Nihlen
    Departments of Respiratory Medicine and Allergology, University Hospital, Lund, Sweden
    Clin Physiol Funct Imaging 23:138-42. 2003
    ..Furthermore, when associated with nasal symptoms, COPD may be associated with an increased nasal secretory responsiveness...
  90. ncbi Allergen-reactive antibodies are found in nasal fluids from patients with birch pollen-induced intermittent allergic rhinitis, but not in healthy controls
    M Benson
    Allergy Laboratory, Department of Oto Rhino Laryngology, Malmo University Hospital, Malmo, Sweden
    Allergy 58:386-92. 2003
    ..The aims of this study were to make a detailed characterization of nasal fluid Igs in birch pollen-induced IAR...
  91. ncbi Preliminary study on Japanese cedar pollinosis in an artificial exposure chamber (OHIO Chamber)
    Kazuhiro Hashiguchi
    Department of Otolaryngology, Kitasato Institute Hospital, Minatoku, Tokyo, Japan
    Allergol Int 56:125-30. 2007
    ..Since satisfactory outcomes were obtained from the controlled pollen exposure at the chamber, we conducted preliminary studies in volunteers with SAR...
  92. ncbi Neural expression and increased lavage fluid levels of secretoneurin in seasonal allergic rhinitis
    Magnus Korsgren
    Department of Clinical Pharmacology, University Hospital, SE 221 85 Lund, Sweden
    Am J Respir Crit Care Med 167:1504-8. 2003
    ..widespread occurrence in nasal mucosal nerves of patients with seasonal allergic rhinitis and that increased nasal lavage fluid levels of secretoneurin may characterize ongoing allergen exposure...
  93. ncbi Cytolysis of eosinophils in nasal secretions
    Kensuke Watanabe
    Department of Otolaryngology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Ann Otol Rhinol Laryngol 112:169-73. 2003
    ....
  94. ncbi Effects of corticosteroids on expression of interleukin-18 in the airway mucosa of a mouse model of allergic rhinitis
    Si Whan Kim
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Seoul National University, Seoul, Korea
    Ann Otol Rhinol Laryngol 116:76-80. 2007
    ..In this study, we aimed to investigate the release and response of interleukin (IL)-18 to steroid treatment in a mouse model of allergic rhinitis...
  95. ncbi Desloratadine reduces allergen challenge-induced mucinous secretion and plasma exudation in allergic rhinitis
    Lennart Greiff
    Department of Otorhinolaryngology, University Hospital, Lund, Sweden
    Ann Allergy Asthma Immunol 89:413-8. 2002
    ..The nasal output of fluid in allergic rhinitis is associated with luminal appearance of bioactive molecules emanating from the microcirculation as well as the secretory apparatus...
  96. ncbi Nasal challenges with recombinant derivatives of the major birch pollen allergen Bet v 1 induce fewer symptoms and lower mediator release than rBet v 1 wild-type in patients with allergic rhinitis
    M van Hage-Hamsten
    Department of Medicine, Division of Clinical Immunology, Karolinska Institute and Hospital, Stockholm, Sweden
    Clin Exp Allergy 32:1448-53. 2002
    ..Genetic engineering of the major birch pollen allergen (Bet v 1) has led to the generation of recombinant Bet v 1 derivatives with markedly reduced IgE-binding capacity, but with retained T cell activating ability...
  97. ncbi Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigen
    Marc A Riedl
    Hart and Louis Lyon Laboratory, Division of Clinical Immunology and Allergy, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    J Immunol 174:7440-5. 2005
    ..Whether this immune response represents durable allergic tolerance is not yet known. Studies investigating the molecular mechanisms of this non-IgE response may be useful in developing therapy to prevent allergic sensitization...
  98. ncbi Nasal responses in asthmatic and nonasthmatic subjects following exposure to diesel exhaust particles
    Johny Kongerud
    Lungeavdelingen, Rikshospitalet, University of Oslo, Oslo, Norway
    Inhal Toxicol 18:589-94. 2006
    ..Nasal cell populations and soluble mediators in the nasal lavage fluid were characterized...
  99. ncbi Targeting adenosine receptors in the treatment of allergic rhinitis: a randomized, double-blind, placebo-controlled study
    J Rimmer
    Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    Clin Exp Allergy 37:8-14. 2007
    ..There is evidence that adenosine plays a role in the pathogenesis of asthma and rhinitis; however, it is currently unclear whether adenosine receptors are useful therapeutic targets in the treatment of allergic airway diseases...
  100. ncbi Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis
    G Di Lorenzo
    Istituto di Medicina Interna e Geriatria, Dipartimento di Biopatologia e Metodologie Biomediche, Universita degli Studi di Palermo, Palermo, Italia
    Int Arch Allergy Immunol 125:164-75. 2001
    ..Polyp histology typically shows chronic, eosinophilic inflammation. The inflammatory cell infiltrate generally includes eosinophils, lymphocytes, plasma cells and mast cells...
  101. ncbi Effects of the inhalation of diesel exhaust, Kanto loam dust, or diesel exhaust without particles on immune responses in mice exposed to Japanese cedar (Cryptomeria japonica) pollen
    K Maejima
    Energy and Environment Research Division, Japan Automobile Research Institute, 2530 Karima, Tsukuba shi, Ibaraki 305 0822, Japan
    Inhal Toxicol 13:1047-63. 2001
    ..Remarkable decrease of interferon-gamma and significant increase of interleukin-4 in the nasal lavage fluid were apparent after DE or DEG exposure, but not in the KLD group...

Research Grants82

  1. INDIVIDUAL FACTORS IN NASAL IRRITANT SENSITIVITY
    Dennis Shusterman; Fiscal Year: 2002
    ..of mast cell degranulation (tryphase) and neuro-immune modulation (nerve growth factor) will be assayed in nasal lavage fluid pre- and post chemical provocation in a subset of subjects...
  2. ENDOTOXIN AND BRONCHIAL INFLAMMATION IN ASTHMA
    David Peden; Fiscal Year: 2001
    ..airway responses of asthmatics who are responsive and non-responsive will be compared to baseline sputum and nasal lavage fluid IL-8 and ECP to determine if either in vitro monocyte responses or IL-8 and ECP in readily obtained airway ..
  3. PROTEOMICS CORE
    Joseph Loo; Fiscal Year: 2006
    ..responses and the role of phase II enzymes in allergic inflammation, (ii) characterize the proteome of human nasal lavage fluid to measure PM-induced oxidative stress responses in human subjects with high and low responses to DEP and to ..
  4. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  5. Social and psychological risk for infectious illness
    Sheldon Cohen; Fiscal Year: 2007
    ..abstract_text> ..
  6. Social and psychological risk for infectious illness
    Sheldon A Cohen; Fiscal Year: 2010
    ..abstract_text> ..
  7. Social and psychological risk for infectious illness
    Sheldon Cohen; Fiscal Year: 2009
    ..abstract_text> ..
  8. Epidemiology of Dental Caries and Immunity in Children
    Noel Childers; Fiscal Year: 2007
    ....
  9. Epidemiology of Dental Caries and Immunity in Children
    Noel Childers; Fiscal Year: 2009
    ....
  10. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2007
    ..abstract_text> ..
  11. Liposomal Recombinant Vaccine and Caries Immunity
    Noel Childers; Fiscal Year: 2007
    ....
  12. Epidemiology of Dental Caries and Immunity in Children
    Noel K Childers; Fiscal Year: 2010
    ....
  13. Epidemiology of Dental Caries and Immunity in Children
    Noel Childers; Fiscal Year: 2009
    ....
  14. Wisconsin Allergy & Immunology Research Training Program
    James Gern; Fiscal Year: 2007
    ..Given these opportunities, the WISCART program can continue to provide trainees with a comprehensive mentored research training experience that will prepare them for successful research careers in Allergy and Immunology. ..
  15. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2007
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  16. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2007
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. ..
  17. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  18. LIPOSOMAL S MUTANS DELIVERY SYSTEM FOR CARIES IMMUNITY
    Noel Childers; Fiscal Year: 2001
    ....
  19. MECHANISMS OF RHINITIS IN CFS
    James Baraniuk; Fiscal Year: 1999
    ..e. nasal provocation) as the means to evaluate future treatments of CFS. ..
  20. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  21. Routes of prion neuroinvasion following oral infection
    RICHARD BESSEN; Fiscal Year: 2006
    ....
  22. PROTECTIVE IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A
    David Briles; Fiscal Year: 1993
    ....
  23. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..pneumoniae is important because of the high complexity and cost of the polysaccharide-protein conjugate vaccine and the rapid evolution of pneumococci to evade the capsule-type-specific protection elicited by the conjugate vaccine. ..
  24. Lifecourse SES and Cardiovascular Disease Risk
    DENISE DEVERTS; Fiscal Year: 2009
    ....
  25. IMMUNITY TO PNEUMOCOCCAL SURFACE PROTEIN A AND C
    David Briles; Fiscal Year: 2002
    ..The data obtained will assist with the development of correlates of protective immunity for PspA and PspC that can be applied to vaccine development. ..
  26. Human Metapneumovirus Infections in Children
    John Williams; Fiscal Year: 2004
    ..The specific aims of this study are to define the prevalence of hMPV infection in children, describe fully the spectrum of clinical illness and identify serologic markers of seroconversion and correlates of immunity. ..
  27. Environmental Determinants of Pulmonary Disease: A new approach to an old problem
    Erik Svendsen; Fiscal Year: 2007
    ..Objective: Increase public and professional preparedness for chemical/radiological disasters). ..
  28. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2007
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  29. Regulation of ENaC by Serine Proteases in Airways
    Scott Donaldson; Fiscal Year: 2006
    ..The PI's long term goals are to provide important new insights into the basic elements of airway defense, CF lung disease, and to bring these findings to the development of novel therapies for CF lung disease. ..