aqueous humor

Summary

Summary: The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)

Top Publications

  1. ncbi 5 alpha-dihydrocortisol in human aqueous humor and metabolism of cortisol by human lenses in vitro
    B I Weinstein
    Department of Ophthalmology, New York Medical College, Valhalla 10595
    Invest Ophthalmol Vis Sci 32:2130-5. 1991
  2. ncbi Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract
    Yasuyuki Takai
    Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan
    Invest Ophthalmol Vis Sci 53:241-7. 2012
  3. ncbi Changes in aqueous humor dynamics with age and glaucoma
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4 340 CSC, 600 Highland Avenue, Madison, WI 53792 3220, USA
    Prog Retin Eye Res 24:612-37. 2005
  4. ncbi Oxidative stress in primary open-angle glaucoma
    Vicente Zanon-Moreno
    Ophthalmologic Research Unit Santiago Grisolia, Dr Peset Universitary Hospital, Valencia, Spain
    J Glaucoma 17:263-8. 2008
  5. pmc Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy
    Raffaele Mancino
    Ophthalmology Unit, Department of Biopathology, Tor Vergata University of Rome, Rome, Italy
    Mol Vis 17:1298-304. 2011
  6. pmc IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma
    Nathalie Cassoux
    Department of Ophthalmology, Hopital Pitie Salpetriere, Paris, France
    Invest Ophthalmol Vis Sci 48:3253-9. 2007
  7. ncbi Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor
    Stephanie C Joachim
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Curr Eye Res 32:501-9. 2007
  8. pmc Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy
    Chui Ming Gemmy Cheung
    Ocular Inflammation and Immunology Services, Singapore National Eye Centre, Singapore
    Mol Vis 18:830-7. 2012
  9. ncbi Tumor necrosis factor-alpha concentrations in the aqueous humor of patients with glaucoma
    Hideko Sawada
    Department of Ophthalmology, Niigata University School of Medicine, Asahimachi, Niigata, Japan
    Invest Ophthalmol Vis Sci 51:903-6. 2010
  10. pmc Extracellular matrix in the trabecular meshwork
    Ted S Acott
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger, Portland, OR 97239 4197, USA
    Exp Eye Res 86:543-61. 2008

Detail Information

Publications289 found, 100 shown here

  1. ncbi 5 alpha-dihydrocortisol in human aqueous humor and metabolism of cortisol by human lenses in vitro
    B I Weinstein
    Department of Ophthalmology, New York Medical College, Valhalla 10595
    Invest Ophthalmol Vis Sci 32:2130-5. 1991
    ..Cortisol metabolites have biologic activity and may affect aqueous humor dynamics...
  2. ncbi Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract
    Yasuyuki Takai
    Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan
    Invest Ophthalmol Vis Sci 53:241-7. 2012
    To measure levels of various inflammatory cytokines in the aqueous humor of patients with primary open-angle glaucoma (POAG), exfoliation glaucoma (EXG), and senile cataract.
  3. ncbi Changes in aqueous humor dynamics with age and glaucoma
    B Ann True Gabelt
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, F4 340 CSC, 600 Highland Avenue, Madison, WI 53792 3220, USA
    Prog Retin Eye Res 24:612-37. 2005
    Changes in aqueous humor dynamics with age and in glaucoma have been studied for several decades...
  4. ncbi Oxidative stress in primary open-angle glaucoma
    Vicente Zanon-Moreno
    Ophthalmologic Research Unit Santiago Grisolia, Dr Peset Universitary Hospital, Valencia, Spain
    J Glaucoma 17:263-8. 2008
    ..To analyze oxidative stress in primary open-angle glaucoma (POAG)...
  5. pmc Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy
    Raffaele Mancino
    Ophthalmology Unit, Department of Biopathology, Tor Vergata University of Rome, Rome, Italy
    Mol Vis 17:1298-304. 2011
    To evaluate levels of malondialdehyde and the total antioxidant capacity (TAC) in the blood, aqueous humor, and vitreous bodies of diabetic and nondiabetic patients. We also measured the blood energy charge potential (ECP).
  6. pmc IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma
    Nathalie Cassoux
    Department of Ophthalmology, Hopital Pitie Salpetriere, Paris, France
    Invest Ophthalmol Vis Sci 48:3253-9. 2007
    To determine the value of IL-10 measurement in aqueous humor (AH) for screening in primary intraocular lymphoma (PIOL).
  7. ncbi Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor
    Stephanie C Joachim
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Curr Eye Res 32:501-9. 2007
    To show the existence of IgG antibodies against retinal antigens in aqueous humor of normal tension glaucoma patients.
  8. pmc Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy
    Chui Ming Gemmy Cheung
    Ocular Inflammation and Immunology Services, Singapore National Eye Centre, Singapore
    Mol Vis 18:830-7. 2012
    To compare the aqueous humor levels of proinflammatory and angiogenic factors of diabetic patients with and without retinopathy.
  9. ncbi Tumor necrosis factor-alpha concentrations in the aqueous humor of patients with glaucoma
    Hideko Sawada
    Department of Ophthalmology, Niigata University School of Medicine, Asahimachi, Niigata, Japan
    Invest Ophthalmol Vis Sci 51:903-6. 2010
    To investigate the concentration of tumor necrosis factor (TNF)-alpha in the aqueous humor of patients with glaucoma, including correlations with glaucoma subtypes and intraocular pressure.
  10. pmc Extracellular matrix in the trabecular meshwork
    Ted S Acott
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger, Portland, OR 97239 4197, USA
    Exp Eye Res 86:543-61. 2008
    ..IOP is regulated primarily by a fluid resistance to aqueous humor outflow...
  11. ncbi Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632
    P V Rao
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina7710, USA
    Invest Ophthalmol Vis Sci 42:1029-37. 2001
    The goal of this study was to investigate the role of Rho kinase in the modulation of aqueous humor outflow facility...
  12. pmc Surgical denervation of ocular sympathetic afferents decreases local transforming growth factor-beta and abolishes immune privilege
    Jose L Vega
    Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA
    Am J Pathol 175:1218-25. 2009
    ..immune privilege is accompanied by a decrease in the concentration of transforming growth factor-beta in the aqueous humor. These results suggest that immune privilege is lost in the absence of a functional sympathetic innervation of ..
  13. pmc Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes
    Jocelyn Chua
    Singapore National Eye Centre, Singapore
    Mol Vis 18:431-8. 2012
    To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes.
  14. ncbi Rho GTPase-mediated cytoskeletal organization in Schlemm's canal cells play a critical role in the regulation of aqueous humor outflow facility
    Janardan Kumar
    Department of Natural Sciences, Becker College, Worcester, Massachusetts 01609, USA
    J Cell Biochem 112:600-6. 2011
    The increased intraocular pressure (IOP) has been considered to be an increased resistance of the aqueous humor outflow through the inner wall of Schlemm's canal (SC) and/or the juxtacanalicular tissue (JCT)...
  15. ncbi Modeling passive mechanical interaction between aqueous humor and iris
    J J Heys
    Department of Chemical Engineering, University of Colorado, Boulder 80309-0424, USA
    J Biomech Eng 123:540-7. 2001
    ..We present here a mathematical model of the coupled aqueous humor-iris system that accountsfor the contribution of aqueous humor flow and passive iris deformability to the iris ..
  16. ncbi Angiogenic and inflammatory markers in the intraocular fluid of eyes with diabetic macular edema and influence of therapy with bevacizumab
    Marion Funk
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Retina 30:1412-9. 2010
    ....
  17. ncbi Corneal endotheliitis associated with evidence of cytomegalovirus infection
    Soon Phaik Chee
    Singapore National Eye Centre, Singapore
    Ophthalmology 114:798-803. 2007
    ..To describe the clinical presentation of cytomegalovirus (CMV) corneal endotheliitis in human immunodeficiency virus (HIV)-negative patients...
  18. ncbi Concentrations of mitomycin C in rabbit corneal tissue and aqueous humor after topical administration
    Jong Suk Song
    Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea
    Cornea 25:S20-3. 2006
    ....
  19. pmc Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization
    Heng Miao
    Department of Ophthalmology, People s Hospital, Peking University, Beijing, China
    Mol Vis 18:574-80. 2012
    ....
  20. ncbi Changes in aqueous concentrations of various cytokines after intravitreal triamcinolone versus bevacizumab for diabetic macular edema
    Hee Jin Sohn
    Department of Ophthalmology, Hongik Hospital, Seoul, Korea
    Am J Ophthalmol 152:686-94. 2011
    ..To investigate the changes in aqueous inflammatory and angiogenic cytokine levels after intravitreal injection of triamcinolone or bevacizumab for reducing foveal thickness in diabetic macular edema (DME)...
  21. pmc Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 50:2276-82. 2009
    ..To study the amelioration of ocular inflammation in endotoxin-induced uveitis (EIU) in rats by benfotiamine, a lipid-soluble analogue of thiamine...
  22. ncbi Usefulness of aqueous humor analysis for the diagnosis of posterior uveitis
    Aniki Rothova
    Department of Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands
    Ophthalmology 115:306-11. 2008
    ..To assess the clinical usefulness of aqueous fluid analysis for the diagnosis and treatment of patients suspected of having infectious posterior uveitis (PU)...
  23. pmc Proteome analysis of human aqueous humor
    Uttio Roy Chowdhury
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Invest Ophthalmol Vis Sci 51:4921-31. 2010
    Human aqueous humor (hAH) provides nutrition and immunity within the anterior chamber of the eye...
  24. ncbi Oxidative stress markers in aqueous humor of glaucoma patients
    Sandra M Ferreira
    Departamento de Química Analítica y Fisicoquímica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Instituto de Quimica y Fisicoquimica Biologica, CONICET, Buenos Aires, Argentina
    Am J Ophthalmol 137:62-9. 2004
    ..The aim of this study was to establish the antioxidant status of aqueous humor of patients with primary open-angle glaucoma...
  25. ncbi What increases outflow resistance in primary open-angle glaucoma?
    Ernst R Tamm
    Institute of Human Anatomy and Embryology, University of Regensburg, Germany
    Surv Ophthalmol 52:S101-4. 2007
    ..open-angle glaucoma is generated in the trabecular meshwork outflow pathways, which provide resistance to aqueous humor outflow...
  26. ncbi Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis
    Peter C Ruokonen
    Augenklinik Charité Universitätsmedizin Berlin CVK Germany, Augustenburger Platz 1, 13353 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 248:565-71. 2010
    ..Fuchs' heterochromic cyclitis (FHC) is a common intraocular disease of uncertain etiology that has recently been related to rubella virus (RV) infection...
  27. ncbi Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 146:508-12. 2008
    ..To investigate intraocular concentrations and pharmacokinetics of bevacizumab after a single intravitreal injection in humans...
  28. ncbi Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion
    Shelley R Boyd
    Moorfields Eye Hospital, City Road, London EC1V 2PD, England
    Arch Ophthalmol 120:1644-50. 2002
    ..To establish a role for vascular endothelial growth factor (VEGF) during the onset and clinical course of neovascularization of the iris (NVI) in ischemic central retinal vein occlusion...
  29. ncbi Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion
    Javier Ruiz-Ederra
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    Exp Eye Res 82:879-84. 2006
    ....
  30. ncbi Aqueous and serum interferon gamma, interleukin (IL) 2, IL-4, and IL-10 in patients with uveitis
    M S Lacomba
    Department of Ophthalmology, Reina Sofia University Clinic, Cordoba, Spain
    Arch Ophthalmol 118:768-72. 2000
    To determine the cytokine profile in aqueous humor and peripheral blood from patients with uveitis.
  31. pmc Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture
    Kate E Keller
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 49:2495-505. 2008
    Glycosaminoglycans (GAGs) have been implicated in the regulation of outflow resistance of aqueous humor flow through the trabecular meshwork (TM)...
  32. pmc Aqueous cytokine and chemokine analysis in uveitis associated with tuberculosis
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Mol Vis 18:565-73. 2012
    ..The aim of this study was to study the aqueous cytokine and chemokine composition in patients with uveitis associated with tuberculosis (TAU)...
  33. ncbi Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa
    Noriko Yoshida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ophthalmology 120:100-5. 2013
    ..To study the nature of inflammatory reaction in eyes of patients with retinitis pigmentosa (RP) and its possible role in the pathogenesis of RP...
  34. ncbi Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator
    Peter A Campochiaro
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Mol Ther 16:791-9. 2008
    ....
  35. ncbi Preclinical pharmacokinetics of Ranibizumab (rhuFabV2) after a single intravitreal administration
    Jacques Gaudreault
    Department of Pharmacokinetic, Genentech Inc, South San Francisco, CA 94080, USA
    Invest Ophthalmol Vis Sci 46:726-33. 2005
    ..This study evaluated the pharmacokinetic (PK) and serum bioavailability of ranibizumab after a single intravitreal (ITV) or intravenous (IV) dose in cynomolgus monkeys...
  36. ncbi Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Germany
    Retina 31:1877-84. 2011
    ..To compare the concentration of unbound bevacizumab in the anterior chamber of patients with macular edema, who received a single intravitreal injection of two different dosages...
  37. ncbi Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma
    Yochai Z Shoshani
    Department of Ophthalmology, Indiana School of Medicine, Indianapolis, Indiana 46202, USA
    Curr Eye Res 37:1-11. 2012
    ....
  38. pmc The Ahmed Baerveldt Comparison Study methodology, baseline patient characteristics, and intraoperative complications
    Keith Barton
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 118:435-42. 2011
    ....
  39. ncbi Sustained mechanical release of dexamethasone sodium phosphate from a foldable capsular vitreous body
    Yaqin Liu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, School of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 51:1636-42. 2010
    ..Since 300-nm-mili apertures were present in the capsule of the foldable capsular vitreous body (FCVB), the authors tested whether the FCVB could mechanically release dexamethasone sodium phosphate (DexP) from its capsule...
  40. ncbi Pars plana anterior vitrectomy, hyaloido-zonulectomy, and iridectomy for aqueous humor misdirection
    Elena Bitrian
    Jules Stein Eye Institute, University of California Los Angeles, USA
    Am J Ophthalmol 150:82-87.e1. 2010
    ..To report a surgical technique for aqueous misdirection refractory to medical treatment consisting of combined pars plana vitrectomy, hyaloido-zonulectomy, and peripheral iridectomy...
  41. pmc Multiplex cytokine analysis reveals elevated concentration of interleukin-8 in glaucomatous aqueous humor
    John Kuchtey
    Vanderbilt Eye Institute, Vanderbilt University, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 51:6441-7. 2010
    ..the hypothesis that immune activation occurs in glaucoma by comparing concentrations of multiple cytokines in aqueous humor (AH) from patients with primary open angle glaucoma (POAG) and from cataract patients without glaucoma as ..
  42. pmc Proteomic analysis of aqueous humor from patients with primary open angle glaucoma
    Xiaoming Duan
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 16:2839-46. 2010
    ..It is known, however, that the expression profile for some proteins in the aqueous humor (AH) changes in some diseases, and that AH changes play important roles in elevated IOP...
  43. ncbi Penetration of topically applied tacrolimus into the aqueous humor in Behçet's disease
    F Nilüfer Yalçindağ
    Ophthalmology Department, Ankara University Faculty of Medicine, Esat Caddes i 74 3 Küçükesat, Ankara, 06660, Turkey
    Ann Ophthalmol (Skokie) 39:15-7. 2007
    We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behçet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0...
  44. ncbi Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis
    Jun Suzuki
    Department of Ophthalmology, Tokyo Medical University Hospital, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Graefes Arch Clin Exp Ophthalmol 248:1487-91. 2010
    ..To determine whether rubella virus is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI)...
  45. ncbi Cytomegalovirus endotheliitis in Descemet's stripping endothelial keratoplasty
    Arundhati Anshu
    Singapore National Eye Center, Singapore
    Ophthalmology 116:624-30. 2009
    ..To report 4 cases of undiagnosed cytomegalovirus (CMV) endotheliitis in patients who underwent Descemet's stripping automated endothelial keratoplasty (DSAEK)...
  46. ncbi Effects of TGF-beta2 in perfused human eyes
    Johannes Gottanka
    Department of Anatomy 2, University of Erlangen Nuremburg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 45:153-8. 2004
    TGF-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open-angle glaucoma (POAG)...
  47. pmc Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor
    Kyle G Howell
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    J Glaucoma 19:569-75. 2010
    To determine the concentration of myocilin in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG) aqueous humor.
  48. ncbi Interleukin-10 and interleukin-6 in aqueous humor during treatment of vitreoretinal lymphoma with intravitreally injected methotrexate
    Hajime Kawamura
    Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Japan
    Ophthalmic Res 42:172-4. 2009
    ..To evaluate the effectiveness of measuring anterior chamber interleukin (IL)-10 and IL-6 concentrations during treatment of vitreoretinal lymphoma with intravitreally injected methotrexate...
  49. ncbi Evaluation of 5-fluorouracil released from a foldable capsular vitreous body in vitro and in vivo
    Haihua Zheng
    the Second Affiliated Hospital of Wenzhou Medical College, 109 West Xueyuan Road, Wenzhou, 325000, China
    Graefes Arch Clin Exp Ophthalmol 250:751-9. 2012
    ..Here, we evaluated the characteristics of the release of 5-fluorouracil (5-Fu) from FCVB in vitro and in vivo...
  50. pmc Effects of sildenafil and tadalafil on intraocular pressure in sheep: implications for aqueous humor dynamics
    Rosana Gerometta
    Departamento de Oftalmologia, Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes, Argentina
    Invest Ophthalmol Vis Sci 51:3139-44. 2010
    To determine the effects of vasodilators on intraocular pressure (IOP) and the protein content of sheep aqueous humor (AH), because the vasodilators may increase fluid leakage from the fenestrated capillaries of the ciliary body to the ..
  51. ncbi Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients
    Danna Mao
    Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China
    Curr Eye Res 37:803-8. 2012
    To study whether aqueous humor (AH) and plasma adiponectin (APN) levels were altered in proliferative diabetic retinopathy (PDR).
  52. ncbi Polymerase chain reaction and Goldmann-Witmer coefficient analysis are complimentary for the diagnosis of infectious uveitis
    Jolanda D F de Groot-Mijnes
    Department of Virology, Eijkman Winkler Center, and F C Donders Institute of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Ophthalmol 141:313-8. 2006
    To determine the relative contribution of the analysis of intraocular antibody production and the polymerase chain reaction (PCR) in aqueous humor (AH) to the diagnosis of infectious uveitis.
  53. ncbi Shunts to divert aqueous humor to distant epithelialized cavities after keratoprosthesis surgery
    Claes H Dohlman
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 19:111-5. 2010
    ..In this retroactive study of such shunts, the risk of postoperative infection (especially endophthalmitis) has been assessed...
  54. pmc Influence of race and age on aqueous humor levels of transforming growth factor-beta 2 in glaucomatous and nonglaucomatous eyes
    Rupal H Trivedi
    Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Ocul Pharmacol Ther 27:477-80. 2011
    To evaluate the influence of race and age on aqueous humor levels of transforming growth factor-beta 2 (TGF-β2).
  55. pmc Proteomic analysis of human aqueous humor using multidimensional protein identification technology
    Matthew R Richardson
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Mol Vis 15:2740-50. 2009
    b>Aqueous humor (AH) supports avascular tissues in the anterior segment of the eye, maintains intraocular pressure, and potentially influences the pathogenesis of ocular diseases...
  56. ncbi Identification of differentially expressed proteins in the aqueous humor of primary congenital glaucoma
    Rachida A Bouhenni
    Department of Ophthalmology Summa Health System, Akron, OH 44304, USA
    Exp Eye Res 92:67-75. 2011
    ..Tryptic digests of the complex mixtures of proteins in aqueous humor were analyzed using Liquid Chromatography/Mass Spectrometry (LC-MS/MS)...
  57. ncbi Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeys
    Fred Y Chien
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Ophthalmol 121:87-90. 2003
    To evaluate the effects of WIN 55212-2, a cannabinoid receptor agonist, on intraocular pressure and aqueous humor dynamics in normal monkeys and monkeys with glaucoma.
  58. ncbi Proteome alterations in primary open angle glaucoma aqueous humor
    A Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, and Department of Head Neck Pathologies, St Martino Hospital, Ophthalmology Unit, Genoa, Italy
    J Proteome Res 9:4831-8. 2010
    ..only nourishment and scavenging source for most of the anterior and posterior chamber tissues in the eye, the aqueous humor represents one of the target for glaucoma...
  59. ncbi Aqueous humor nitric oxide levels in patients with Behçet disease
    Gursel Yilmaz
    Department of Ophthalmology, Baskent University Faculty of Medicine, Turkey
    Retina 22:330-5. 2002
    The purpose of this study was to quantify aqueous humor nitric oxide levels in patients with Behçet uveitis and age-matched controls to assess how nitric oxide is involved in this ocular condition.
  60. ncbi Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion
    H Noma
    Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Eye (Lond) 22:42-8. 2008
    ....
  61. ncbi Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery
    Zhongqiu Li
    Laboratory of Ophthalmology, Catholic University Leuven, Leuven, Belgium
    Invest Ophthalmol Vis Sci 50:5217-25. 2009
    ....
  62. ncbi Glaucoma drainage implants: a critical comparison of types
    Kenneth S Schwartz
    Georgetown University Hospital, Washington Hospital Center, Washington, District of Columbia, USA
    Curr Opin Ophthalmol 17:181-9. 2006
    ..The purpose of this review is to critically compare the various glaucoma drainage implants in popular use...
  63. ncbi Aqueous humor dynamics in mice
    Makoto Aihara
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
    Invest Ophthalmol Vis Sci 44:5168-73. 2003
    To assess aqueous humor dynamics in mouse eyes.
  64. ncbi Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients
    Soon Phaik Chee
    Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 145:834-40. 2008
    ..To describe the clinical presentation of cytomegalovirus (CMV) anterior uveitis in human immunodeficiency virus (HIV)-negative patients...
  65. ncbi Somatostatin is an immunosuppressive factor in aqueous humor
    Andrew W Taylor
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:2644-9. 2003
    To detect the presence of somatostatin (SOM) in normal aqueous humor and to characterize its immunosuppressive activity.
  66. ncbi Aqueous humor and plasma vascular endothelial growth factor in uveitis-associated cystoid macular edema
    H F Fine
    Harvard Medical School, Boston, Massachusetts, USA
    Am J Ophthalmol 132:794-6. 2001
    To determine the association between cystoid macular edema and vascular endothelial growth factor concentration in the aqueous humor and plasma of uveitis patients.
  67. ncbi Inflammatory and angiogenic factors in the aqueous humor and the relationship to diabetic retinopathy
    In Kyung Oh
    Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea
    Curr Eye Res 35:1116-27. 2010
    ..To determine the relationship between the aqueous concentrations of inflammatory and angiogenic factors and the severity of diabetic retinopathy and diabetic macular edema...
  68. ncbi Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy
    Osamu Sawada
    Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan
    Arch Ophthalmol 125:1363-6. 2007
    To study the concentration of vascular endothelial growth factor in the aqueous humor before and after intravitreal injection of bevacizumab in eyes with proliferative diabetic retinopathy.
  69. ncbi Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility
    Priyatham Sai Mettu
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 45:2263-71. 2004
    To investigate the role of lysophospholipid growth factors in the regulation of aqueous humor outflow in the trabecular meshwork (TM).
  70. ncbi Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma
    Vasantha P Rao
    Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA
    BioDrugs 21:167-77. 2007
    ..Several lines of experimental evidence indicate that modulating ROCK activity within the aqueous humor outflow pathway using selective inhibitors could achieve very significant benefits for the treatment of ..
  71. ncbi Cytokine profiles in toxoplasmic and viral uveitis
    Ibtissem Lahmar
    Institut de Parasitologie et de Pathologie Tropicale, Universite de Strasbourg, Strasbourg, France
    J Infect Dis 199:1239-49. 2009
    Uveitis is a major cause of visual impairment throughout the world. Analysis of cytokine profiles in aqueous humor specimens may provide insight into the physiopathological processes that underly retinal damage in this context.
  72. ncbi Concentration of vascular endothelial growth factor in aqueous humor of eyes with advanced retinopathy of prematurity before and after intravitreal injection of bevacizumab
    Norie Ito Nonobe
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
    Retina 29:579-85. 2009
    To determine whether an intravitreal injection of bevacizumab alters the concentration of vascular endothelial growth factor (VEGF) in the aqueous humor of eyes with retinopathy of prematurity.
  73. ncbi Acute effects of insulin on aqueous humor flow in patients with type 1 diabetes
    J T Lane
    Department of Internal Medicine, University of Nebraska Medical Center and Nebraska Health System, Omaha, NE 68198, USA
    Am J Ophthalmol 132:321-7. 2001
    Previous studies reported reduced aqueous humor flow through the anterior segment of the eye in patients with type 1 diabetes...
  74. pmc Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes
    W Daniel Stamer
    Department of Ophthalmology and Vision Science, The University of Arizona, 655 North Alvernon Way, Suite 108, Tucson, AZ 85711, USA
    Exp Eye Res 89:980-8. 2009
    ..Regardless, S1P receptor antagonists represent novel therapeutic prospects for ocular hypertension in humans...
  75. ncbi Hepatocyte growth factor is increased in the aqueous humor of glaucomatous eyes
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York 10003, USA
    J Glaucoma 10:152-7. 2001
    To assess the concentrations of hepatocyte growth factor (HGF) in the aqueous humor of eyes with glaucoma compared with control eyes with cataract only.
  76. pmc Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression
    Walter Paper
    Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany
    Exp Eye Res 87:257-67. 2008
    ..To assess the effects of elevated amounts of myocilin on aqueous humor outflow dynamics in an in vivo system, transgenic betaB1-crystallin-MYOC mice have been developed that ..
  77. pmc Multiplex immunoassay analysis of biomarkers in clinically accessible quantities of human aqueous humor
    Rajesh K Sharma
    Department of Ophthalmology, University of Florida, College of Medicine, Jacksonville, FL 32209, USA
    Mol Vis 15:60-9. 2009
    b>Aqueous humor is intimately related to the cells of the anterior and posterior chambers, which affect its composition. Aqueous analysis provides useful information regarding physiological and pathophysiological processes in the eye...
  78. ncbi Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes
    M Inatani
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Graefes Arch Clin Exp Ophthalmol 239:109-13. 2001
    ..characteristics are correlated with increased levels of transforming growth factor-beta 2 (TGF-beta 2) in aqueous humor in glaucomatous eyes. METHODS: Aqueous humor samples were collected from 91 glaucomatous eyes...
  79. pmc Alterations in the intraocular cytokine milieu after intravitreal bevacizumab
    Farzin Forooghian
    Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1204, USA
    Invest Ophthalmol Vis Sci 51:2388-92. 2010
    ..The etiology of these complications remains unclear. The purpose of this study was to characterize changes in the intraocular levels of inflammatory cytokines after IVB as a possible explanation for these complications...
  80. ncbi Inflammatory mediators of uveitis: cytokines and chemokines
    S John Curnow
    Institute of Biomedical Research, Division of Immunity and Infection, Medical School, The University of Birmingham, UK
    Curr Opin Ophthalmol 17:532-7. 2006
    ..Recent developments in cytokine and chemokine detection have overcome many of these problems. This review presents a summary of the technologic advances in this area...
  81. ncbi Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema
    Bram van Kooij
    F C Donders Institute of Ophthalmology, Utrecht, The Netherlands
    Am J Ophthalmol 142:192-4. 2006
    To investigate the global cytokine and chemokine expression pattern in the aqueous humor of uveitis patients and relate them to clinical features.
  82. ncbi Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens
    Keiryn L Bennett
    Center for Molecular Medicine of the Austrian Academy of Sciences CeMM, Vienna, Austria
    J Proteomics 74:151-66. 2011
    ..Complementary to molecular function, the predominant biological processes for the proteins in aqueous humour are assigned to inflammatory and immune responses, and transport...
  83. ncbi Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor
    J Ortego
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Invest Ophthalmol Vis Sci 37:2759-67. 1996
    ..To study the expression of the neurotrophic pigment epithelium-derived factor (PEDF), a protein with neurotrophic and neuronal-survival activities, by the human ocular ciliary epithelium...
  84. ncbi Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients
    C B Toris
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198 5540, USA
    Am J Ophthalmol 128:8-14. 1999
    To report the acute vs chronic effects of brimonidine, a selective alpha2-adrenergic receptor agonist, on aqueous humor dynamics in ocular hypertensive patients.
  85. ncbi Proteomics of the aqueous humor in healthy New Zealand rabbits
    Miroslava Stastna
    Department of Medicine, Johns Hopkins Bayview Proteomics Center, Johns Hopkins University, Baltimore, MD 21224, USA
    Proteomics 7:4358-75. 2007
    There are several physiological roles postulated for aqueous humor, a liquid located in the anterior and posterior chamber of the eye, such as maintenance of the intraocular pressure, provision of nutrients, and removal of metabolic ..
  86. ncbi Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development
    G Picht
    Department of Ophthalmology, , Josef Schneider Strasse 11, , Germany
    Graefes Arch Clin Exp Ophthalmol 239:199-207. 2001
    ..To investigate the transforming growth factor beta 2 (TGF-beta 2) levels and total protein levels in the aqueous humor of eyes with different types of glaucoma [primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PSX),..
  87. ncbi Increased vascular endothelial growth factor levels in aqueous humor and serum of patients with quiescent uveitis
    M P Paroli
    Uveitis Center, Department of Ophthalmology, Policlinico Umberto I University Hospital, Roma, Italy
    Eur J Ophthalmol 17:938-42. 2007
    ..Both substances have been suggested to play a key role in uveitis pathogenesis. The authors analyzed VEGF and IL-8 levels in the aqueous humor and serum of patients with different types of uveitis during a quiet phase of the disease.
  88. ncbi Intraocular cytokine environment in active Behçet uveitis
    Jae Kyoun Ahn
    Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea
    Am J Ophthalmol 142:429-34. 2006
    To determine cytokine profiles in aqueous humor and peripheral blood from patients with Behçet uveitis.
  89. ncbi Giant vacuole survival time and implications for aqueous humor outflow
    H S Brilakis
    Department of Ophthalmology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    J Glaucoma 10:277-83. 2001
    ..This suggests that they can respond rapidly to intraocular pressure changes and thus can serve as markers of aqueous pressure differences across the inner and outer walls of Schlemm's canal...
  90. ncbi New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland
    Miguel Coca-Prados
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA
    Prog Retin Eye Res 26:239-62. 2007
    ..glutamate-metabolizing enzymes, and anti-angiogenic factors requires a reevaluation of its function on aqueous humor secretion, intraocular pressure and its role in glaucoma...
  91. ncbi Membrane Fas ligand activates innate immunity and terminates ocular immune privilege
    Meredith S Gregory
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 169:2727-35. 2002
    ..The higher threshold is due to the suppressive microenvironment found within aqueous humor that blocks membrane FasL activation of neutrophils...
  92. ncbi Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion
    Hidetaka Noma
    Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women s Medical University, Chiba, Japan
    Eur J Ophthalmol 20:402-9. 2010
    ..We investigated whether aqueous and vitreous levels of these molecules were correlated in CRVO patients...
  93. ncbi Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork
    Dorette Z Ellis
    Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32610, USA
    Invest Ophthalmol Vis Sci 50:1808-13. 2009
    Nitric oxide (NO) increases the rate at which aqueous humor exits the eye; however, the involvement of soluble guanylate cyclase (sGC) is unknown...
  94. ncbi Effect of intravitreal bevacizumab injection on aqueous humor cytokine levels in clinically significant macular edema
    Mi In Roh
    The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    Ophthalmology 116:80-6. 2009
    To determine the effect of intravitreal bevacizumab (Avastin, Genentech, Inc., San Francisco, CA) injection on aqueous humor cytokine levels in clinically significant macular edema (CSME).
  95. ncbi Specific antibody levels in the aqueous humor and serum of two distinct populations of patients with ocular toxoplasmosis
    Justus G Garweg
    Department of Ophthalmology, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Int J Med Microbiol 295:287-95. 2005
    ..Paired samples of aqueous humor and serum were withdrawn from 27 Brazilian and 50 Swiss patients presenting consecutively with active ocular ..
  96. ncbi Primary trabecular meshwork cells incubated in human aqueous humor differ from cells incubated in serum supplements
    Michael P Fautsch
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 46:2848-56. 2005
    To determine whether aqueous humor, the in vivo source of nutrients for trabecular meshwork cells, alters cellular and molecular characteristics in primary trabecular monolayer cell cultures when compared with standard culture conditions.
  97. ncbi Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis
    Ahmed M Abu El-Asrar
    Department of Ophthalmology, King Abdulaziz University Hospital, College of Medicine, King Saud University, Old Airport Road, PO Box 245, Riyadh 11411, Saudi Arabia
    Clin Immunol 139:177-84. 2011
    We assayed aqueous humor (AH) samples from patients with Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-γ and ..
  98. ncbi [Aqueous humor and serum interleukin-6 in patients with uveitis]
    M Santos Lacomba
    Departamento de Oftalmologia, Hospital Universitario Reina Sofía de Córdoba, Espana
    Arch Soc Esp Oftalmol 76:345-50. 2001
    ..A study on local and systemic behavior of interleukin-6 in patients with active uveitis...
  99. pmc Aqueous humor outflow: what do we know? Where will it lead us?
    Michael P Fautsch
    Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 47:4181-7. 2006
  100. ncbi Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility
    P Vasantha Rao
    Department of Ophthalmology, Duke University Medical Center, Box 3802, Durham, NC 27710, USA
    Exp Eye Res 80:197-206. 2005
    ....
  101. ncbi Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt-Koyanagi-Harada disease
    Shuhong Jiang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, People s Republic of China
    Br J Ophthalmol 94:1078-82. 2010
    ..This study was designed to investigate the role of IL-17-producing T helper (Th17) cell-related pro-inflammatory cytokines on postoperative inflammation in VKH patients...

Research Grants65

  1. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..For successful IOP reduction, maintaining filtering blebs, which consist of the subconjunctival space where aqueous humor is drained into after GFS, is a key...
  2. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..Both POAG and NTG patients show elevation of endothelin-1 (ET-1), a potent vasoactive peptide, in their aqueous humor and circulation respectively...
  3. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..with lens epithelial cells;cultured in HCEC- conditioned medium or co-cultured with HCEC;and then cultured in aqueous humor. The effect of these culture conditions on MSCs will be followed by identifying changes in characteristics ..
  4. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    ..An increase in rigidity of the HTM cells might lead to increased resistance to aqueous humor outflow...
  5. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..fluids and tissue homogenates including retina/choroid, lens, iris-ciliary body, sclera, vitreous humor and aqueous humor (3) to determine enzymatic stability of steroids, their peptide prodrugs and bevacizumab (i) alone, (ii) ..
  6. Role of trabecular meshwork contractility in modulating outflow resistance
    CHEE HIAN TAN; Fiscal Year: 2013
    ..His postdoctoral research was in trabecular meshwork and aqueous humor cell biology and physiology with respect to glaucoma...
  7. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..We will map pO2 levels and measure aqueous humor antioxidants and outflow facility at each stage...
  8. BIOLOGY OF TRABECULAR RESPONSE TO LASER TRABECULOPLASTY
    Ted S Acott; Fiscal Year: 2012
    ..our recent results with this system, our focus now is to identify the molecular component(s) that comprise the aqueous humor outflow resistance and regulate IOP...
  9. Development Of An Eye Drop To Treat Presbyopia
    William H Garner; Fiscal Year: 2012
    ..a topical ocular formulation of our co-drug to achieve therapeutic levels of active agent in the rabbit aqueous humor without adversely affecting cornea health and lens metabolism...
  10. Characterization of purified myocilin: glaucoma as a protein misfolding disease
    Raquel L Lieberman; Fiscal Year: 2013
    ..Pressure is controlled in the anterior region of the eye, within the anatomical pathway for outflow of aqueous humor, called the trabecular extracellular meshwork (TEM)...
  11. Autophagic Lysosomal Pathway and Glaucoma
    PALOMA LITON; Fiscal Year: 2013
    ..from several laboratories, including ours, support a key role of reactive oxygen species, both present in the aqueous humor as well as generated during the normal aging process within the outflow pathway, in the pathogenesis of ..
  12. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    ..intraocular pressure (IOP) due to failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow...
  13. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2012
    ..In primary open-angle glaucoma (POAG), elevated intraocular pressure (IOP) is often attributed to diminished aqueous humor (AH) outflow facility caused by accumulation of extracellular matrix material (ECM) in the juxtacanicular ..
  14. Cellular Physiology of the Aqueous Outflow Pathway
    Haiyan Gong; Fiscal Year: 2013
    ..of primary open-angle glaucoma (POAG) is elevation of the intraocular pressure (IOP), resulting from a rise in aqueous humor outflow resistance. To date, the cause of this elevated resistance in POAG remains unknown...
  15. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..of coupling light in and out of the eye and measure the in vivo equilibration time delay between blood and aqueous humor glucose levels...
  16. External Glaucoma Drainage Device
    Bruce Klitzman; Fiscal Year: 2012
    ..To circumvent many of the problems with existing procedures, we propose a novel GDD that drains aqueous humor externally;and thereby, avoids fibrous capsule formation over the outlet end of the device...
  17. MicroRNA-directed modulation of intraocular pressure
    Benjamin R tenOever; Fiscal Year: 2013
    ..medical treatments are usually inadequate and do not target the conventional outflow pathway;the main route of aqueous humor egress and the site of extra resistance in POAG patients with elevated IOP...
  18. Determining Molecular and Cellular Mechanisms of Glaucoma
    KAYARAT SAIDAS NAIR; Fiscal Year: 2013
    ..This results in inefficient aqueous humor exits, thereby causing high intraocular pressure (IOP) and glaucoma...
  19. Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance
    Sayoko E Moroi; Fiscal Year: 2013
    ..Our central hypothesis is that individual aqueous humor dynamic components predict IOP response to medications...
  20. Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow
    P Vasantha Rao; Fiscal Year: 2013
    ..and is commonly associated with elevation of intraocular pressure (IOP) resulting from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork (TM) and Schlemm's canal (SC)...
  21. Long-Acting Mucus-Penetrating Steroid Particles for Treatment of Eye Inflammation
    Hongming Chen; Fiscal Year: 2011
    ..Aim 2, we will demonstrate that a single instillation of PA MPP will maintain drug concentration in rabbit aqueous humor for 12 h above that of PRED MILD(R) at 6 h (based on PRED MILD(R) at 4W/day)...
  22. Oxidative Stress and Lysosomal Function in the Outflow Pathway
    PALOMA LITON; Fiscal Year: 2009
    ..pressure (IOP) that results from the failure of the conventional outflow pathway to maintain normal levels of aqueous humor (AH) outflow resistance...
  23. Control of Trabecular Meshwork Cytoskeleton
    Donna M Peters; Fiscal Year: 2011
    ..They are commonly associated with elevated levels of intraocular pressure (IOP) due to a reduction in aqueous humor outflow from the trabecular meshwork (TM)...
  24. Retinal Laser Burn Abolishes Ocular Immunity Privilege
    Kenyatta G Lucas; Fiscal Year: 2010
    ..We will use knowledge from previous studies that detail components (Aqueous humor, F4/80+ Antigen presenting cells and T-regulatory cells) of the immune system important for ocular immune ..
  25. PRESSURE REGULATION OF HUMAN TRABECULAR MESHWORK GENES
    TERESA BORRAS; Fiscal Year: 2012
    ..In humans, 90% of the aqueous humor exits the eye through the trabecular meshwork (TM)...
  26. Glucocorticoids, ocular hypertension, and glaucoma
    Thomas Yorio; Fiscal Year: 2013
    ..similar to POAG, and GC effects on the trabecular meshwork (TM), the tissue responsible for regulating aqueous humor outflow (and therefore IOP), mimic many of the molecular and biochemical changes that occur in POAG...
  27. METABOLISM OF THE TRABECULAR MESHWORK
    David L Epstein; Fiscal Year: 2011
    ..acts to negatively modulate the stress-induced induction of TGF-beta1 and IL-6, thereby causing an increase in aqueous humor outflow resistance...
  28. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cause of the elevated aqueous humor outflow resistance associated with primary open angle glaucoma (POAG) is unknown...
  29. Study of Aqueous Humor Dynamics in a Pediatric Population
    Vikas Gulati; Fiscal Year: 2013
    ..development award to obtain training in the techniques involved in the assessment of human and vertebrate aqueous humor dynamics...
  30. sGCa1-deficient mice: a novel murine model of elevated IOP and glaucoma
    Bruce R Ksander; Fiscal Year: 2012
    ..Elevated intraocular pressure (IOP), determined by the balance between aqueous humor secretion and aqueous humor outflow, is considered an important risk factor for glaucoma...
  31. Hypothalamic Control of IOP, ICP, and the Translaminar Pressure Gradient
    BRIAN CHRISTOPHER SAMUELS; Fiscal Year: 2013
    ..Specific Aim #1 will include training in fluorophotometric analysis of aqueous humor production and in vivo recording of outflow facility immediately following chemical stimulation of the DMH/PeF ..
  32. Real time imaging of the aqueous outflow pathway by two-photon endoscopy
    Hiroshi Nakamura; Fiscal Year: 2009
    ..intraocular pressure of primary open angle glaucoma is related to an increased resistance to the outflow of aqueous humor. The precise location of the resistance and the mechanisms by which aqueous humor outflow is impaired, however,..
  33. CORE GRANT FOR VISION RESEARCH
    Oscar A Candia; Fiscal Year: 2011
    ..Areas of active research include glaucoma;cataracts;corneal diseases;comeal repair and immunology;aqueous humor dynamics;fluid and electrolyte transport in cornea, lens and ciliary epithelium;role of membrane receptors in ..
  34. Restoration of Trabecular Meshwork by hMSC and Induced Pluripotent Stem Cells
    MARY JANE KELLEY; Fiscal Year: 2013
    ..By culturing with aqueous humor, ECM components, different media preparations, and/or other agents, we will alter the local milieu of the stem ..
  35. Mechanisms of Aqueous Humor Homeostasis -- Role of Monocytes
    Jorge A Alvarado; Fiscal Year: 2013
    ..interact with SCE cells in a paracrine manner, thus forming a cellular module that regulates the outflow of aqueous humor. The specific aims are to test particular predictions of this hypothesis about the roles of monocytes by: [1] ..
  36. Extracellular Matrix and Outflow Resistance
    Kate E Keller; Fiscal Year: 2013
    ..Elevated IOP is caused by increased resistance to aqueous humor outflow through the trabecular meshwork (TM)...
  37. A Fluorescence-based Optomechanical Sensor for Intraocular Pressure Monitoring
    NIKOLAOS CHRONIS; Fiscal Year: 2013
    ..range, precision error, etc) will be established in vitro by immersing the NIFO sensor into a bath filled with aqueous humor. 2) Construction of the Optical Readout System (ORS)...
  38. Identifying a Disease Gene Causing Primary Open Angle Glaucoma
    Rachel W Kuchtey; Fiscal Year: 2012
    ..Based on our preliminary results, we project that the gene will be novel and involved in aqueous humor outflow regulation.
  39. VERTEBRATE EYE: STUDIES OF AQUEOUS OUTFLOW
    Ted S Acott; Fiscal Year: 2012
    ..An obstruction to aqueous humor outflow, primarily through the trabecular meshwork (TM), produces elevated intraocular pressure (IOP), which ..
  40. Novel emulsion-based formulation of the anti-glaucoma MSH-1001 for improved topic
    Ronald A Wassel; Fiscal Year: 2011
    ..project is to demonstrate that an emulsion based eye drop can deliver therapeutic levels of MSH-100, to the aqueous humor with the long term goal (Phase 2) of reducing intraocular pressure in an appropriate animal model of ocular ..
  41. The Retroject Device: A Novel Approach to Glaucoma Drug Delivery
    Molly McCarthy Walsh; Fiscal Year: 2013
    ..IOP and aqueous humor outflow facility will be evaluated to determine the effect of the injection on these parameters...
  42. Aqueous Humor Outflow Control and Intraocular Pressure
    MORTIMER MORDECAI CIVAN; Fiscal Year: 2013
    ..IOP depends directly on inflow rate and resistance to outflow of aqueous humor, and available data suggest that A3 and A1 receptors likely modulate inflow and outflow, respectively...
  43. Crystallin-Derived Mini-Chaperones as Protein Aggregation Inhibitors
    Krishna K Sharma; Fiscal Year: 2011
    ..the protein myocilin misfolds and aggregates in the trabecular meshwork, interfering with the outflow of aqueous humor and causing elevated intraocular pressure...
  44. SOLUTE TRANSPORT MECHANISMS IN THE CILIARY BODY
    Nicholas A Delamere; Fiscal Year: 2013
    ..established by Na, K-ATPase in the nonpigmented ciliary epithelium (NPE) are vital to the secretion of aqueous humor. We seek to understand the mechanisms that control Na,K-ATPase activity...
  45. HYDROGEN SULFIDE-RELEASING COMPOUNDS AND IOP REGULATION
    Ya Fatou Njie-Mbye; Fiscal Year: 2012
    ..In this proposed study, we hypothesize that H2S-releasing compounds can regulate IOP and aqueous humor dynamics by an effect that is mediated via conventional and/ uveoscleral pathways...
  46. Targeting the Anterior Segment with Homing Peptides from Phage Display
    Donna M Peters; Fiscal Year: 2013
    ..They are commonly associated with elevated levels of intraocular pressure (IOP) due to a reduction in aqueous humor outflow from the TM...
  47. Proteomic Biomarkers for AMD
    John W Crabb; Fiscal Year: 2013
    ..In aim 2, we will test the hypothesis that the aqueous humor (AH) proteome offers new insights to AMD mechanisms and biomarkers...
  48. Integrin Signaling in the Trabecular Meshwork
    Donna M Peters; Fiscal Year: 2012
    ..They are commonly associated with elevated levels of intraocular pressure (IOP) due to a reduction in aqueous humor outflow from the trabecular meshwork (TM)...
  49. Mechanical Interaction between Aqueous Humor and Iris
    Victor Barocas; Fiscal Year: 2009
    ..The computational studies will involve extension of our previous models of the aqueous humor- iris system to include the following: dynamic active tension of the iris sphincter (already included in ..
  50. Cannabinoid Receptors and Novel Antiglaucoma Drugs
    Zhao Hui Song; Fiscal Year: 2010
    ..cannabinoid receptors are expressed on the trabecular meshwork (TM) cells, and cannabinoid agonists enhance aqueous humor outflow through both CB1 and CB2 receptors...
  51. GPR119: A novel means to lower intraocular pressure?
    ALEXANDER J STRAIKER; Fiscal Year: 2012
    ..Notably, GPR119 is expressed prominently in the trabecular meshwork, responsible for outflow of aqueous humor. Preliminary functional experiments show that OEA reduces intraocular pressure (IOP) by 30% in the mouse...
  52. IN VIVO INHIBITORS OF OCULAR PROSTAGLANDIN SYNTHESIS
    STEVEN PODOS; Fiscal Year: 1980
    ..Arachidonic acid, a precursor of PGE2, elevates intraocular pressure and aqueous humor protein when applied topically...
  53. Protection of Ocular Tissues During Inflammation
    MELVIN MEDOF; Fiscal Year: 2006
    ..grant cycle, we showed that functionally active soluble forms of the molecules are present in tears and aqueous humor, and obtained evidence that changes in the cell-associated regulators are clinically relevant in ocular ..
  54. HYDROGEN PEROXIDE IN AQUEOUS HUMOR
    SIXTO GARCIA CASTINEIRAS; Fiscal Year: 1990
    Hydrogen peroxide has been found in the aqueous humor of several animal species including man, at the low uM level (5 to 90 uM)...
  55. EXTRACELLULAR MATRIX IN GLAUCOMA
    PAUL KNEPPER; Fiscal Year: 2002
    ..A key question in POAG is to identify cell factors that would adversely affect 1) normal aqueous humor outflow, 2) optic nerve function, and 3) glaucoma surgery...
  56. ADRENERGIC & CHOLINERGIC MECHANISMS IN GLAUCOMA THERAPY
    JON POLANSKY; Fiscal Year: 1993
    ..it has not been possible to study drug effects directly on the target cells involved in the regulation of aqueous humor inflow and outflow...
  57. Redefining the Model of the Blood-Aqueous Barrier
    Thomas Freddo; Fiscal Year: 2005
    In the existing model of the blood-aqueous barrier (BAB), elevations in the very low levels of protein in the aqueous humor are attributed to increased permeability of the tight junctions in the iris vasculature and ciliary epithelium...
  58. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    ..They occur in the ciliary epithelium that produces the ocular fluid (aqueous humor) and in cells of the aqueous humor drainage (outflow) pathway...
  59. OCULAR ACTIONS OF ENDOTHELINS
    Thomas Yorio; Fiscal Year: 2005
    ..Recently, it has been shown that patients with primary open angle glaucoma (POAG) have an elevation in their aqueous humor endothelin (ET) concentrations...
  60. ANTERIOR CHAMBER FLUID ACETYLCHOLINE CONCENTRATION
    Jonathan Wirtschafter; Fiscal Year: 1980
    The origin(s), fate, and physiologic actions of endogenous acetylcholine (ACh) in the aqueous humor are little understood but may be important, particularly since cholinergic drugs are used to reduce intraocular pressure in glaucoma...
  61. REGULATION OF TRABECULAR CELL GLYCOPROTEINS
    John Samples; Fiscal Year: 1991
    ..glaucoma is a common, insidious ophthalmic disorder characterized by an increased resistance to outflow of aqueous humor. Extracellular matrix (ECM) has been implicated as a major component of the barrier outflow...
  62. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    ..To demonstrate the activity of the neuropeptides with TGF-beta in the eye, the effects of normal aqueous humor. which contains the immunoregulatory cytokines produced in the eye, on effector T-cell activities will be ..
  63. DRUG METABOLISM IN THE EYE
    Hitoshi Shichi; Fiscal Year: 2001
    ..higher susceptibility of anterior tissues to drug toxicity than posterior tissues is not well understood but aqueous humor production and drug metabolizing activities associated with ciliary body appear to be important factors...
  64. ION AND WATER TRANSPORT IN CILIARY EPITHELIUM
    NASSER FARAHBAKHSH; Fiscal Year: 2001
    DESCRIPTION: The eye relies on the aqueous humor for nutrition of the cornea, lens, vitreous and trabecular meshwork, as well as the removal of the waste products of metabolism from these tissues...
  65. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 2009
    DESCRIPTION: The trabecular meshwork (TM) is a major site for regulation of the aqueous humor outflow. Cells in the TM are essential for maintenance of the normal aqueous outflow...