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Genomes and Genes
| salivaSummarySummary: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin. Top Publications
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Publications
Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory researchSally S Dickerson
Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
Psychol Bull 130:355-91. 2004..These findings are consistent with the animal literature on the physiological effects of uncontrollable social threat and contradict the belief that cortisol is responsive to all types of stressors...
Exosomes from human saliva as a source of microRNA biomarkersA Michael
Sjögren s Syndrome Clinic, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
Oral Dis 16:34-8. 2010The aim of this study was to examine the presence of microRNAs (miRNAs) within exosomes isolated from human saliva and to optimize and test methods for successful downstream applications.
Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent changeJens C Pruessner
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
Psychoneuroendocrinology 28:916-31. 2003..It is shown that depending on which formula is used, different associations with other variables may emerge. Consequently, it is recommended to employ both formulas when analyzing data sets with repeated measures...
The role of saliva in tick feedingIvo M B Francischetti
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda MD, USA
Front Biosci 14:2051-88. 2009..This supplemental file is accessble fromhttp://exon.niaid.nih.gov/transcriptome/tick_review/Sup-Table-1.xls.gz...
Pyrosequencing analysis of the oral microflora of healthy adultsB J F Keijser
TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Zeist, The Netherlands
J Dent Res 87:1016-20. 2008..We hypothesized that the species richness of human oral microflora is underestimated. Saliva and supragingival plaque were sampled from 71 and 98 healthy adults, respectively...
Study of inter- and intra-individual variations in the salivary microbiotaVladimir Lazarevic
Genomic Research Laboratory, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
BMC Genomics 11:523. 2010..Culture-independent approaches provide the best means to assess the diversity of oral bacteria because most of them remain uncultivable...
Global diversity in the human salivary microbiomeIvan Nasidze
Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Genome Res 19:636-43. 2009..We analyzed 14,115 partial ( approximately 500 bp) 16S ribosomal RNA (rRNA) sequences from saliva samples from 120 healthy individuals (10 individuals from each of 12 worldwide locations)...
Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and salivaAngel Balmaseda
National Center for Diagnosis and Reference, Ministry of Health, Granada, Nicaragua
Clin Diagn Lab Immunol 10:317-22. 2003..dengue virus (DEN) infection, the detection of DEN-specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva specimens was assessed in 147 patients with symptoms of DEN infection seen at the Ministry of Health in Nicaragua...
Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector controlPapa M Drame
Institut de recherche pour le developpement IRD, UR024 Epidémiologie et Prévention Unit, Dakar, Senegal
Am J Trop Med Hyg 83:115-21. 2010..This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs)...
Characterization of the antibody response to the saliva of Phlebotomus papatasi in people living in endemic areas of cutaneous leishmaniasisSoumaya Marzouki
Department of Clinical Immunology, Institut Pasteur de Tunis, 13 Place Pasteur, Le Belvedere, Tunisia
Am J Trop Med Hyg 84:653-61. 2011Important data obtained in mice raise the possibility that immunization against the saliva of sand flies could protect from leishmaniasis...
Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivoH Koo
Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
Caries Res 44:116-26. 2010..mutans biofilm formation on saliva-coated hydroxyapatite surface, and on dental caries development in Sprague-Dawley rats...
Smoke-free homes in England: prevalence, trends and validation by cotinine in childrenM J Jarvis
Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK
Tob Control 18:491-5. 2009..Main outcome measures were cotinine measured in saliva, smoke-free homes defined by "no" response to "Does anyone smoke inside this house/flat on most ..
Measurement of recent exposure to Phlebotomus argentipes, the vector of Indian visceral Leishmaniasis, by using human antibody responses to sand fly salivaMeredith F Clements
London School of Hygiene and Tropical Medicine, London, United Kingdom
Am J Trop Med Hyg 82:801-7. 2010Antibody (IgG) responses to the saliva of Phlebotomus argentipes were investigated using serum samples from regions of India endemic and non-endemic for visceral leishmaniasis (VL)...
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly salivaTatiana R de Moura
Centro de Pesquisas Goncalo Moniz, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Brazil
PLoS Negl Trop Dis 1:e84. 2007Sand fly saliva has an array of pharmacological and immunomodulatory components, and immunity to saliva protects against Leishmania infection...
Detection of species-specific antibody response of humans and mice bitten by sand fliesI Rohousova
Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
Parasitology 130:493-9. 2005Sand fly saliva plays an important role in Leishmania transmission. We characterized the host antibody response to saliva from 3 sand fly species...
Evaluation of the antibody response to Anopheles salivary antigens as a potential marker of risk of malariaFranck Remoue
Institut de recherche pour le developpement IRD, UR24 Epidémiologie et Prévention Unit, Centre IRD de Hann, BP 1386, Dakar, Senegal
Trans R Soc Trop Med Hyg 100:363-70. 2006..The specific antibody (Ab) IgG response to saliva obtained from Anopheles gambiae mosquitoes was evaluated in young children from an area of seasonal malaria ..
The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune responseBradley S Schneider
Institut Pasteur, Departement de Parasitologie, Unités de Réponses Précoces aux Parasites et Immunopathologie, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Trans R Soc Trop Med Hyg 102:400-8. 2008..Arboviruses, including dengue and West Nile virus, are injected into vertebrates within mosquito saliva during mosquito feeding...
Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inflammatory bowel diseaseLi Zhang
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, Sydney, New South Wales 2052, Australia
J Clin Microbiol 48:2965-7. 2010The presence of Campylobacter concisus in the saliva of healthy individuals and patients with inflammatory bowel disease (IBD) was examined. C...
Stability of salivary steroids: the influences of storage, food and dental careM Groschl
Hospital for Children and Adolescents, Friedrich Alexander University, Erlangen Nurnberg, Germany
Steroids 66:737-41. 2001..b>Saliva samples of healthy adults (n = 15; m:8; f:7) were collected directly before and after dental care, and directly ..
Anti-Anopheles darlingi saliva antibodies as marker of Plasmodium vivax infection and clinical immunity in the Brazilian AmazonBruno Bezerril Andrade
Centro de Pesquisas Gonçalo Moniz FIOCRUZ, Bahia, Brazil
Malar J 8:121. 2009..Thus, innovative strategies are needed to reduce disease burden. The malaria vectors, through the injection of saliva into the host skin, play important role on disease transmission and may influence malaria morbidity...
Comparative analysis of human saliva microbiome diversity by barcoded pyrosequencing and cloning approachesIvan Nasidze
Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
Anal Biochem 391:64-8. 2009..with a barcoded pyrosequencing method to see whether the latter accurately describes microbiome diversity in human saliva. Our results indicate that despite the shorter read lengths, the pyrosequencing approach provides a description of ..
Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infectionXueqing Xu
Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
J Biol Chem 286:32383-93. 2011..longipalpis saliva. Additionally, splenocytes of exposed mice produce IFN-γ upon stimulation with LJM11, demonstrating the systemic ..
Detection of trypanosome-specific antibodies in saliva, towards non-invasive serological diagnosis of sleeping sicknessV Lejon
Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
Trop Med Int Health 11:620-7. 2006The detection of trypanosome-specific antibodies in saliva is technically feasible, and, if clinically validated, could become an attractive option for non-invasive diagnosis of sleeping sickness...
Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical AfricaEve Orlandi Pradines
Unité de recherche en biologie et en épidémiologie parasitaires, Institut de Medecine Tropicale du Service de Sante des Armees, Parc le Pharo, BP 46, 13998 Marseille Armees, France
Microbes Infect 9:1454-62. 2007..The IgM and IgG antibody responses of 88 French soldiers against the saliva of Anopheles gambiae and Aedes aegypti were evaluated before and after a 5-month journey in tropical Africa...
Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassayNicholas J Haley
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA
PLoS ONE 4:e4848. 2009..Here we report the presence of infectious prions in the urine and saliva of deer with chronic wasting disease (CWD)...
A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatiteErvin I Weiss
Department of Prosthodontics, Faculty of Dentistry, Hebrew University Hadassah, Jerusalem, Israel
FEMS Microbiol Lett 232:89-92. 2004..In vitro, the cranberry constituent inhibited the adhesion of Streptococcus sobrinus to saliva-coated hydroxyapatite...
Salivary transcriptomic biomarkers for detection of resectable pancreatic cancerLei Zhang
School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California 90095, USA
Gastroenterology 138:949-57.e1-7. 2010....
Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinomaAndre Lopes Carvalho
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0910, USA
Clin Cancer Res 14:97-107. 2008..To evaluate aberrant promoter hypermethylation of candidate tumor suppressor genes as a means to detect epigenetic alterations specific to solid tumors, including head and neck squamous cell carcinoma (HNSCC)...
Prenatal anxiety predicts individual differences in cortisol in pre-adolescent childrenThomas G O'Connor
Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA
Biol Psychiatry 58:211-7. 2005..This study examined the long-term association between prenatal anxiety and measures of diurnal cortisol at age 10 years...
Using recombinant proteins from Lutzomyia longipalpis saliva to estimate human vector exposure in visceral Leishmaniasis endemic areasAna Paula Souza
Centro de Pesquisas Goncalo Moniz, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Brazil
PLoS Negl Trop Dis 4:e649. 2010Leishmania is transmitted by female sand flies and deposited together with saliva, which contains a vast repertoire of pharmacologically active molecules that contribute to the establishment of the infection...
Nanostructural and transcriptomic analyses of human saliva derived exosomesVISWANATHAN PALANISAMY
Department of Craniofacial Biology, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
PLoS ONE 5:e8577. 2010..They are ubiquitous in most body fluids (breast milk, saliva, blood, urine, malignant ascites, amniotic, bronchoalveolar lavage, and synovial fluids)...
Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencingZongxin Ling
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
Microb Ecol 60:677-90. 2010..and PCR-denaturing gradient gel electrophoresis (DGGE) to examine bacterial diversity of oral microbiota in saliva and supragingival plaques from 60 children aged 3 to 6 years old with and without dental caries from China...
Salivary flow patterns and the health of hard and soft oral tissuesColin Dawes
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Manitoba, Canada
J Am Dent Assoc 139:18S-24S. 2008This nonsystematic review summarizes the effects of saliva on some of the diseases affecting the hard and soft oral tissues.
Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1Elizabeth A Shirtcliff
Department of Psychology, University of New Orleans, 2006 Geology Psychology Building, New Orleans, LA 70148, USA
Proc Natl Acad Sci U S A 106:2963-7. 2009....
Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and womenMark Hamer
Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
Eur Heart J 31:424-9. 2010..We examined the cross-sectional association between the cortisol response to laboratory-induced mental stress and a marker of sub-clinical coronary atherosclerosis...
Assessing salivary cortisol in large-scale, epidemiological researchEmma K Adam
School of Education and Social Policy and Institute for Policy Research, Northwestern University, United States
Psychoneuroendocrinology 34:1423-36. 2009....
Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortexShaozheng Qin
Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
Biol Psychiatry 66:25-32. 2009..However, it remains unknown whether acute stress has immediate effects on WM-related prefrontal activity...
Antibodies from dogs with canine visceral leishmaniasis recognise two proteins from the saliva of Lutzomyia longipalpisDiana Bahia
Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Parasitol Res 100:449-54. 2007The saliva of the sand fly Lutzomyia longipalpis, a major vector of Leishmania, exhibits pharmacological and immunomodulatory activities that may facilitate entry and establishment of parasites into the vertebrate host...
Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic menAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Alcohol Clin Exp Res 34:1246-56. 2010....
Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasiSami Ben Hadj Ahmed
Laboratory of Vector Ecology, Laboratory of Epidemiology and Ecology of Parasites, and Laboratory of Immuno Pathology, Vaccinology, and Molecular Genetics, Institut Pasteur de Tunis, Tunis, Tunisia
Am J Trop Med Hyg 83:512-4. 2010Immunity to saliva of Phlebotomus papatasi protects against Leishmania major infection as determined by co-inoculation of parasites with salivary gland homogenates (SGHs) of this vector...
Mosquito saliva causes enhancement of West Nile virus infection in miceLinda M Styer
New York State Department of Health, Wadsworth Center, Albany, New York 12201, USA
J Virol 85:1517-27. 2011..of mice with WNV mixed with salivary gland extract (SGE) led to higher viremia, demonstrating that mosquito saliva is the major cause of mosquito-induced enhancement...
Dynamics of the salivary gland hypertrophy virus in laboratory colonies of Glossina pallidipes (Diptera: Glossinidae)Adly M M Abd-Alla
Insect Pest Control Laboratory, Joint FAO IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria
Virus Res 150:103-10. 2010..The virus is excreted in the saliva and there is a strong correlation between the infection status (negative, slight or strong by PCR) and the numbers ..
Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensisTatiana R de Moura
Centro de Pesquisas Goncalo Moniz, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Brazil
PLoS Negl Trop Dis 4:e712. 2010During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been ..
Do salivary antibodies reliably reflect both mucosal and systemic immunity?Per Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Norway
Ann N Y Acad Sci 1098:288-311. 2007Two major antibody classes operate in saliva: secretory IgA (SIgA) and IgG. The former is synthesized as dimeric IgA by plasma cells (PCs) in salivary glands and is exported by the polymeric Ig receptor (pIgR)...
The relative importance of family socioeconomic status and school-based peer hierarchies for morning cortisol in youth: an exporatory studyPatrick West
MRC Social and Public Health Sciences Unit, 4, Lilybank Gardens, Glasgow G12 8RZ, UK
Soc Sci Med 70:1246-53. 2010..Overall, the results highlight the greater importance of school-based peer groups than family SES for young people's psychoneuroendocrine response...
Detection of dengue virus in saliva and urine by real time RT-PCRTelma R Poloni
Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Ribeirão Preto14040 903, Sao Paulo, Brasil
Virol J 7:22. 2010..The objective of this study was to analyze the usefulness of urine and saliva samples for early diagnosis of DENV infection by real time RT-PCR...
Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophagesCecilia Lässer
Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Box 424, 405 30 Gothenburg, Sweden
J Transl Med 9:9. 2011..Our aim was therefore to determine the presence of RNA in exosomes from human saliva, plasma and breast milk and whether these exosomes can be taken up by macrophages.
Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy womenErno J Hermans
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
Neuroimage 52:277-83. 2010..By showing a potential mechanism underlying central reinforcement of androgen use, the present findings may moreover have implications for our understanding of the pathophysiology of AAS dependency...
Lutzomyia longipalpis saliva or salivary protein LJM19 protects against Leishmania braziliensis and the saliva of its vector, Lutzomyia intermediaNatalia M Tavares
Centro de Pesquisa Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, Brazil
PLoS Negl Trop Dis 5:e1169. 2011Leishmania transmission occurs in the presence of insect saliva. Immunity to Phlebotomus papatasi or Lutzomyia longipalpis saliva or salivary components confers protection against an infection by Leishmania in the presence of the ..
A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigensElena Ambrosino
IRBA and UMR6236, Marseille, France
Malar J 9:317. 2010..Thus, the aim of this study was to develop a sensitive tool to assess the exposure to malaria or to bites from the vector Anopheles gambiae, despite anti-malarial prophylactic treatment...
Impact of stressors in a natural context on release of cortisol in healthy adult humans: a meta-analysisKathy Michaud
Department of Psychology, Carleton University, Ottawa, Ont, Canada
Stress 11:177-97. 2008..Nevertheless, there are ample data suggesting that stressful events, through their actions on cortisol levels and reactivity, may influence psychological and physical pathology...
Saliva specimen: a new laboratory tool for diagnostic and basic investigationSilvia Chiappin
Section of Clinical Biochemistry, Department of Medical Diagnostic Sciences and Spec Ther, University of Padua, c o ex Istituto di Semeiotica Medica, Via Ospedale 105 35128, Padova, Italy
Clin Chim Acta 383:30-40. 2007The assay of saliva is an increasing area of research with implications for basic and clinical purposes...
Tropheryma whipplei in patients with pneumoniaSabri Bousbia
CNRS IRD Faculte de Medecine, Marseille, France
Emerg Infect Dis 16:258-63. 2010..PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T...
Proteins in the saliva of the Ixodida (ticks): pharmacological features and biological significanceN A Steen
Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia
Toxicon 47:1-20. 2006The saliva of ticks (Suborder Ixodida) is critical to their survival as parasites...
Biofilm formation of Candida albicans is variably affected by saliva and dietary sugarsYe Jin
Faculty of Dentistry, The University of Hong Kong, Oral Biosciences, 5/F, Prince Philip Dental Hospital 34, Hong Kong, Hong Kong
Arch Oral Biol 49:789-98. 2004..Therefore we examined the effect of human whole saliva and dietary sugars, glucose and galactose on the adhesion and biofilm formation of Candida albicans. Biofilms of C...
The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cellsThomas E Grys
Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 1300 University Ave, Room 481 MSC, Madison, WI 53706, USA
Infect Immun 73:1295-303. 2005..two new substrates for StcE, mucin 7 and glycoprotein 340, and that purified StcE reduces the viscosity of human saliva. We tested the hypothesis that StcE contributes to intimate adherence of EHEC to host cells by cleavage of ..
Human glandular salivas: their separate collection and analysisE C Veerman
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam ACTA, Vrije Universiteit, The Netherlands
Eur J Oral Sci 104:346-52. 1996Human saliva is secreted by the three pairs of major salivary glands (parotid, submandibular, and sublingual), and numerous minor ones, e.g. labial, buccal and (glosso)palatine glands...
Exosome-like vesicles with dipeptidyl peptidase IV in human salivaYuko Ogawa
Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
Biol Pharm Bull 31:1059-62. 2008b>Saliva contains a large number of proteins that participate in the protection of oral tissue. We found, for the first time, small vesicles (30-130 nm in diameter) in human whole saliva...
Insight into the sialome of the castor bean tick, Ixodes ricinusJindrich Chmelar
Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic
BMC Genomics 9:233. 2008..Here, we focused on the sialome of the European vector of Lyme disease, Ixodes ricinus...
Aging and salivary cytokine concentrations as predictors of whole saliva flow rates among women: a preliminary studyCharles Streckfus
Department of Research, School of Dentistry, University of Mississippi Medical Center, Jackson, Miss 30216 4505, USA
Gerontology 48:282-8. 2002How aging influences the secretion of saliva is not entirely clear. Postmortem studies have demonstrated that, with age, the parenchyma of the salivary glands is gradually replaced by fat, connective tissue, and oncocytes...
Saliva-derived DNA performs well in large-scale, high-density single-nucleotide polymorphism microarray studiesMelanie Bahlo
The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
Cancer Epidemiol Biomarkers Prev 19:794-8. 2010..performed a multiple sclerosis (MS) GWAS where a substantial component of the cases (24%) had DNA derived from saliva. Genotyping was done on the Illumina genotyping platform using the Infinium Hap370CNV DUO microarray...
Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkersN Homann
Research Unit of Alcohol Diseases, Helsinki University Central Hospital, Helsinki, Finland
Oral Oncol 37:153-8. 2001..was conducted to evaluate the role of dental status on the microbial production of acetaldehyde from ethanol in saliva. The microbial acetaldehyde production from ethanol was related to the dental score in 132 volunteers...
Discovery of markers of exposure specific to bites of Lutzomyia longipalpis, the vector of Leishmania infantum chagasi in Latin AmericaClarissa Teixeira
Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
PLoS Negl Trop Dis 4:e638. 2010..Though some proteins are immunogenic and have potential as markers of vector exposure, their identity and vector specificity remain elusive...
The accuracy of self-reported smoking: a systematic review of the relationship between self-reported and cotinine-assessed smoking statusSarah Connor Gorber
Health Measures Analysis Section, Health Information and Research Division, Statistics Canada, 24th Floor R H Coats Building, 100 Tunney s Pasture Driveway, Ottawa, ON, Canada K1A 0T6
Nicotine Tob Res 11:12-24. 2009..Smoking is a leading cause of premature mortality and preventable morbidity. Surveillance is most often based on self-reported data, but studies have shown that self-reports tend to underestimate smoking status...
Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infectionMathieu Dubrulle
Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
PLoS ONE 4:e5895. 2009..albopictus. As Ae. albopictus tends to replace Ae. aegypti in many regions, one question remained: is Ae. albopictus as efficient as Ae. aegypti to transmit the variant E1-226V of CHIKV?..
Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatiteH Koo
Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, Brazil
Caries Res 34:418-26. 2000..different regions of Brazil on the activity of separate, purified Gtf enzymes in solution and on the surface of saliva-coated hydroxyapatite (sHA) beads were evaluated...
Male gamblers have significantly greater salivary cortisol before and after betting on a horse race, than do female gamblersC Franco
Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
Physiol Behav 99:225-9. 2010..Whether these gender differences in HPA activation contribute to gender-related differences in gambling behavior is the subject of ongoing investigation...
Salivary cortisol response in mother-infant dyads at high psychosocial riskE Morelius
Department of Molecular and Clinical Medicine Division of Paediatrics, Linkoping University Hospital, Linkoping, Sweden
Child Care Health Dev 33:128-36. 2007..The aim of the present study was to investigate the adrenocortical response to diaper change in mother-infant dyads with psychosocial risk factors...
Characteristics of biofilm formation by Streptococcus mutans in the presence of salivaSug Joon Ahn
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
Infect Immun 76:4259-68. 2008..carrying mutations affecting the localization or expression of P1, in the presence of fluid-phase or adsorbed saliva or salivary agglutinin preparations. Whole saliva- and salivary agglutinin-induced aggregation of S...
Diagnostic accuracy of NicAlert cotinine test strips in saliva for verifying smoking statusFiona Cooke
Market Economics Ltd, Auckland, New Zealand
Nicotine Tob Res 10:607-12. 2008..Unfortunately, information on the validity and reliability of some test strips in urine and saliva samples is not always available...
The salivary glands and saliva of Anopheles gambiae as an essential step in the Plasmodium life cycle: a global proteomic studyValérie Choumet
Unité de Biochimie et de Biologie Moléculaire des Insectes, Institut Pasteur, Paris Cedex 15, France
Proteomics 7:3384-94. 2007..To describe A. gambiae salivary gland and saliva contents, we combined several techniques: 1-DE, 2-DE and LC MS/MS...
Is the cortisol awakening rise a response to awakening?Ines Wilhelm
Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
Psychoneuroendocrinology 32:358-66. 2007..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
Body fat, energy balance and estradiol levels: a study based on hormonal profiles from complete menstrual cyclesA Ziomkiewicz
Institute of Anthropology, Polish Academy of Science, Wroclaw, Poland
Hum Reprod 23:2555-63. 2008..Female fecundity is regulated by nutritional status. Although widely cited, this hypothesis is not strongly supported by empirical data from non-obese, healthy women of reproductive age...
Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humansErno J Hermans
Helmholtz Institute, Utrecht University, The Netherlands
Biol Psychiatry 63:263-70. 2008..Disorders of impulsive aggression in humans have likewise been associated with high testosterone levels, but human evidence for the link between testosterone and aggression remains correlational and inconclusive...
Chronic maternal stress affects growth, behaviour and hypothalamo-pituitary-adrenal function in juvenile offspringJeff Emack
CIHR program in Maternal Adversity Vulnerability and Neurodevelopment MAVAN, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
Horm Behav 54:514-20. 2008..In conclusion, CMS leads to modification of growth trajectory, locomotor activity and adrenocortical responses to stress in juvenile offspring. Further, males appear considerably more vulnerable to these effects than females...
Trypanosoma cruzi infection is enhanced by vector saliva through immunosuppressant mechanisms mediated by lysophosphatidylcholineRafael D Mesquita
Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, UFRJ, 21940 590, Rio de Janeiro, RJ, Brazil
Infect Immun 76:5543-52. 2008..However, parasite infection occurs through the wound produced by insect mouthparts. Saliva of the Triatominae bug Rhodnius prolixus is a source of lysophosphatidylcholine (LPC)...
HPV detection rate in saliva may depend on the immune system efficiencyMaria Adamopoulou
Department of Maxillofacial Surgery, University of Athens Medical School, Athens, Greece
In Vivo 22:599-602. 2008..For example, saliva is an oral fluid that may play a role in HPV transmission, although the detection rates of the virus are lower ..
Variable cortisol circadian rhythms in children with autism and anticipatory stressBlythe A Corbett
Department of Psychiatry and Behavioral Sciences, The M I N D Institute, Sacramento, CA 95817, USA
J Psychiatry Neurosci 33:227-34. 2008....
Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]racloprideJens C Pruessner
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
J Neurosci 24:2825-31. 2004..These data suggest that aversive stressful events can be associated with mesolimbic dopamine release in humans, and that the method presented here may be useful to study the effects of early life events on neurobiological stress systems...
Medication adherence in the MTA: saliva methylphenidate samples versus parent report and mediating effect of concomitant behavioral treatmentElizabeth Pappadopulos
Columbia University, USA
J Am Acad Child Adolesc Psychiatry 48:501-10. 2009..Moreover, adherence measures often rely on parent report of medication use, and their validity and reliability are unknown...
Paper-based microfluidic devices for analysis of clinically relevant analytes present in urine and salivaScott A Klasner
Department of Chemistry, Kansas State University, 213 Chemistry Biochemistry Building, Manhattan, KS 66506, USA
Anal Bioanal Chem 397:1821-9. 2010..microfluidic chip for the quantification of acetoacetate in artificial urine, as well as nitrite in artificial saliva. Glucose assays were based on those previously demonstrated (Martinez et al...
Aggregatibacter actinomycetemcomitans builds mutualistic biofilm communities with Fusobacterium nucleatum and Veillonella species in salivaSaravanan Periasamy
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
Infect Immun 77:3542-51. 2009..essential for growth, and we investigated multispecies community interactions resulting in mutualistic growth on saliva as the sole nutritional source...
Moderate versus severe early life stress: associations with stress reactivity and regulation in 10-12-year-old childrenMegan R Gunnar
Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
Psychoneuroendocrinology 34:62-75. 2009..Lack of effects of severe ELS even for growth delayed children may reflect the restorative effects of adoption or the generally low responsiveness of this age group to the TSST-C...
Salivary sex hormones during the menstrual cyclePeter Celec
Department of Molecular Biology, Comenius University, Bratislava, Slovakia
Endocr J 56:521-3. 2009..This study shows that analysis of salivary levels of sex steroids are informative and can be used in neuroendocrine, chronobiological and other research areas, when repeated sampling is needed...
Detection of Plasmodium falciparum histidine-rich protein II in saliva of malaria patientsNana O Wilson
Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, Georgia 30310, USA
Am J Trop Med Hyg 78:733-5. 2008..Plasmodium falciparum histidine-rich protein II (PfHRP II) levels in plasma and saliva were compared in malaria-positive and -negative patients in Ghana...
Day-to-day differences in cortisol levels and molar cortisol-to-DHEA ratios among working individualsMin Soo Kim
Department of Statistics, Chonnam National University, Gwangju, Korea
Yonsei Med J 51:212-8. 2010..The present study was carried out to determine day-to-day differences in cortisol levels and the molar cortisol-to-dehydroepiandrosterone (DHEA) ratio (molar C/D ratio) in working subjects...
Increased waking salivary cortisol levels in young people at familial risk of depressionZola N Mannie
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
Am J Psychiatry 164:617-21. 2007..The present study sought to answer this question by measuring waking salivary cortisol levels in young people at familial risk of depression but with no personal history of mood disorder...
The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: evidence from a large chemical surveyDirk W Lachenmeier
Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D 76187 Karlsruhe, Germany
Food Chem Toxicol 46:2903-11. 2008..Assuming an equal distribution between the beverage and saliva, the residual acetaldehyde concentrations in the saliva after swallowing could be on average 195 microM for beer, ..
Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and womenWilliam R Lovallo
Veterans Affairs Medical Center, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Pharmacol Biochem Behav 83:441-7. 2006..00001). Caffeine may elevate cortisol by stimulating the central nervous system in men but may interact with peripheral metabolic mechanisms in women...
Total antioxidant levels of saliva in children related to caries, age, and genderO Tulunoglu
Department of Pedodontics, Faculty of Dentistry, University of Gazi, Ankara, Turkey
Int J Paediatr Dent 16:186-91. 2006The purpose of this study was to evaluate the relationship between the physicochemical properties of saliva such as flow rate, buffering capacity, pH, calcium level, total protein, total antioxidant status, and dental caries, age, and ..
Detection of anti-pertussis toxin IgG in oral fluids for use in diagnosis and surveillance of Bordetella pertussis infection in children and young adultsDavid J Litt
Respiratory and Systemic Infection Laboratory and Virus Reference Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
J Med Microbiol 55:1223-8. 2006..This oral fluid ELISA will greatly assist in the convenience of B. pertussis disease diagnosis and surveillance...
Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessmentGuy Caljon
Unit of Cellular and Molecular Immunology, Flanders Interuniversity Institute for Biotechnology VIB, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
Int J Parasitol 36:1025-35. 2006..Increasing attention is being paid to the effects of tsetse fly saliva deposited at the feeding site, which enables the blood-feeding process and putatively promotes parasite ..
Compliance with saliva sampling protocols: electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjectsBrigitte M Kudielka
Department of Experimental Psychology II, , Germany
Psychosom Med 65:313-9. 2003OBJECTIVE: Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations...
Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall II cohortSabine R Kunz-Ebrecht
University College London, Department of Epidemiology and Public Health, 1-19 Torrington Place, London WC1E 6BT, UK
Psychoneuroendocrinology 29:516-28. 2004..by excluding participants who reported a delay of more than 10 min between waking up and taking the first saliva sample...
Triatoma infestans apyrases belong to the 5'-nucleotidase familyEric Faudry
Chagas' Disease Multidisciplinary Research Laboratory, Department of Pathology, Faculty of Medicine, , Brazil 70.910-900
J Biol Chem 279:19607-13. 2004..6.1.5) present in a variety of organisms. The apyrase activity found in the saliva of hematophagous insects is correlated with the prevention of ADP-induced platelet aggregation of the host during ..
Exposure to postnatal depression predicts elevated cortisol in adolescent offspringSarah L Halligan
Winnicott Research Unit, School of Psychology, University of Reading, 3 Earley Gate, Whiteknights, Reading RG6 6AL, United Kingdom
Biol Psychiatry 55:376-81. 2004..Because maternal depression confers added risk for depression to children, these alterations might provide a link between early events and later psychopathology...
Alcohol consumption and cancer of the gastrointestinal tractMikko P Salaspuro
Research Unit of Substance Abuse Medicine, University Central Hospital of Helsinki, Biomedicum Helsinki, PL 700, 00029 HUS, Helsinki, Finland
Best Pract Res Clin Gastroenterol 17:679-94. 2003..This results in high local acetaldehyde concentrations in the saliva and contents of the large intestine...
Assessment of environmental tobacco smoke exposure in children with asthmatic symptoms by questionnaire and cotinine concentrations in plasma, saliva, and urineS Willers
Department of Occupational and Environmental Medicine, Lund University, Sweden
J Clin Epidemiol 53:715-21. 2000..There were strong correlations between urinary and saliva cotinine concentrations and also, though to a lesser extent, between these media and plasma...
Correlation between child caries incidence and S. mutans/lactobacilli in saliva after correction for confounding factorsA Sullivan
Department of Pedodontics, University of Lund, School of Dentistry, , Sweden
Community Dent Oral Epidemiol 17:240-4. 1989The correlation between caries incidence and Streptococcus mutans/lactobacilli in saliva was studied in two different age groups, followed from ages 5 to 7 and from 12 to 14...
Associations between stress reactivity and sexual and nonsexual risk taking in young adult human malesCarolyn Tucker Halpern
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
Horm Behav 42:387-98. 2002..Findings are discussed in terms of cross-situational consistency of stress responses, the utility of stress reactivity for understanding individual differences in risk taking, and the interpretive limitations imposed by study design...
Diurnal cortisol decline is related to coronary calcification: CARDIA studyKaren Matthews
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychosom Med 68:657-61. 2006....
Research Grants
- NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINSFrances Walker; Fiscal Year: 2009The saliva of the blood-sucking insect, Rhodnius prolixus, originally from the Amazon river basin, which carries the parasite Trypanasoma cruzi, the vector of Chagas' disease, contains a suite of heme proteins that we have named ..
- NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINSFrances Walker; Fiscal Year: 2009The saliva of the blood-sucking insect, Rhodnius prolixus, originally from the Amazon river basin, which carries the parasite Trypanasoma cruzi, the vector of Chagas' disease, contains a suite of heme proteins that we have named ..
- Influence of Genetics and Air Pollution Exposures on Birth OutcomesKathleen Mortimer; Fiscal Year: 2007..as low birth weight and premature birth, and (b) evaluate the feasibility of assembling a birth-cohort to provide saliva samples for the analysis of genetic susceptibility to the effects of air pollution on birth outcomes...
- The role of sand fly saliva in visceralization of Leishmania parasites.Gregory Lanzaro; Fiscal Year: 2007It is well known that substances in the saliva of Phlebotomine sand flies enhance pathogenesis of leishmanial parasites in their mammalian hosts and exacerbates the pathology these parasites produce...
- The role of sand fly saliva in visceralization of Leishmania parasitesGregory Lanzaro; Fiscal Year: 2009It is well known that substances in the saliva of Phlebotomine sand flies enhance pathogenesis of leishmanial parasites in their mammalian hosts and exacerbates the pathology these parasites produce...
- NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINSFrances Walker; Fiscal Year: 2006We have discovered a series of heme proteins in the saliva of the blood-sucking bug Rhodnius prolixus that act as vasodilators, anti-platelet aggregation and anti-histaminic agents when injected into the victim...
- NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINSFRANCES ANN WALKER; Fiscal Year: 2010The saliva of the blood-sucking insect, Rhodnius prolixus, originally from the Amazon river basin, which carries the parasite Trypanasoma cruzi, the vector of Chagas'disease, contains a suite of heme proteins that we have named ..
- SALIVARY IMMUNE RESPONSE TO COMMENSAL ORAL BACTERIAMichael Cole; Fiscal Year: 1993..Secretory immunoglobulin A (SigA) antibodies reactive with commensal bacteria are present in saliva but their impact ont he normal flora is not known...
- REGULATION OF IMMUNE RESPONSE IN THE ORAL CAVITYSuzanne Michalek; Fiscal Year: 2003..g., teeth. Secretory IgA antibodies in saliva are important in protection against oral diseases, including Streptococcus mutans-induced dental caries, and are ..
- DEFINING PRIMARY HHV-6 AND HHV7 INFECTIONS IN CHILDRENDanielle Zerr; Fiscal Year: 2003..Data from symptom diaries will be correlated with primary infection as defined by onset of the viruses in saliva. Documentation of seroconversion is the current gold standard for diagnosis of HHV-6 infection, but by definition, ..
- IN VIVO STUDIES OF SALIVA ANTIMICROBIAL PROTEINSJOEL RUDNEY; Fiscal Year: 2001..In vitro studies have identified saliva proteins involved in each process...
- [Ca2+]i and Secretory Dynamics in Parotid Acinar CellsDavid Yule; Fiscal Year: 2007b>Saliva is vital for oral health. It is essential for the hydration of the oral mucosa; it provides lubrication, begins nutrient digestion and imparts antimicrobial and mechanical protection for the mouth and upper gastrointestinal tract...
- Intra-Oral Biofilm FormationSigmund Socransky; Fiscal Year: 2004..Two important bulk fluids, saliva and GCF, bathe the biofilm surfaces and play and undetermined role in biofilm development...
- PMCA Detection of CWD Infection in Cervid and Non-Cervid SpeciesEDWARD ARTHUR HOOVER; Fiscal Year: 2010..We have found that infectious prions capable of transmitting CWD are present in the saliva, blood, and urine of CWD-infected deer, potentially explaining the lateral transmission of the disease...
- ORAL MUCOSA MICROBIOTA IN HEALTH, CANCER & MUCOSITISDonna Mager; Fiscal Year: 2004..To compare the microbial composition of samples from 8 different oral mucous membrane sites with that found in saliva, supra and sub-gingival plaque in subjects stratified according to periodontal status (health or disease) and ..
- Demographic Analysis of Healthy Longevity in ChinaYi Zeng; Fiscal Year: 2009..We plan to collect saliva DNA using Oragene tool kits from voluntary participants among 15,409 interviewees in the sample of about 937 ..
