gastric acid

Summary

Summary: Hydrochloric acid present in GASTRIC JUICE.

Top Publications

  1. ncbi Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis
    Thomas Wultsch
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pain 134:245-53. 2008
  2. ncbi Control of gastric acid secretion in health and disease
    Mitchell L Schubert
    Department of Medicine, Division of Gastroenterology, Virginia Commonwealth University s Medical College of Virginia, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 134:1842-60. 2008
  3. pmc Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion
    T Koike
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    Gut 49:330-4. 2001
  4. ncbi Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotypes
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 77:302-11. 2005
  5. pmc Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects
    G Lux
    Department of Medicine A, University of Erlangen Nuremberg, Germany
    Gut 35:1026-9. 1994
  6. ncbi No potassium, no acid: K+ channels and gastric acid secretion
    Dirk Heitzmann
    Institute of Physiology, Regensburg, Germany
    Physiology (Bethesda) 22:335-41. 2007
  7. ncbi Different dosage regimens of rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotype status
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Pharmacol Ther 76:290-301. 2004
  8. ncbi In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents
    Sonia Mesia-Vela
    Natural Products Section, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, 04044 020 Rua 03 de Maio 100, Sao Paulo, SP, Brazil
    J Ethnopharmacol 111:403-8. 2007
  9. ncbi Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice
    Laura Piqueras
    Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain
    Peptides 25:1287-95. 2004
  10. ncbi Considerations for long-term use of proton-pump inhibitors
    W R Garnett
    School of Pharmacy, Virginia Commonwealth University, Medical College of Virginia, Richmond 23298 0533, USA
    Am J Health Syst Pharm 55:2268-79. 1998

Detail Information

Publications341 found, 100 shown here

  1. ncbi Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis
    Thomas Wultsch
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pain 134:245-53. 2008
    b>Gastric acid challenge of the rat and mouse stomach is signalled to the brainstem as revealed by expression of c-Fos. The molecular sensors relevant to the detection of gastric mucosal acidosis are not known...
  2. ncbi Control of gastric acid secretion in health and disease
    Mitchell L Schubert
    Department of Medicine, Division of Gastroenterology, Virginia Commonwealth University s Medical College of Virginia, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 134:1842-60. 2008
    Recent milestones in the understanding of gastric acid secretion and treatment of acid-peptic disorders include the (1) discovery of histamine H(2)-receptors and development of histamine H(2)-receptor antagonists, (2) identification of H(+..
  3. pmc Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion
    T Koike
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    Gut 49:330-4. 2001
    ..Helicobacter pylori infection is less prevalent and atrophic gastritis is less extensive in patients with reflux oesophagitis than those without it, but few studies have examined this relationship directly...
  4. ncbi Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotypes
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 77:302-11. 2005
    ..We compared the effectiveness of an increased dosage regimen of rabeprazole with that of a concomitant dosage regimen of rabeprazole with famotidine, relative to cytochrome P450 (CYP) 2C19 genotype status, on nocturnal acid inhibition...
  5. pmc Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects
    G Lux
    Department of Medicine A, University of Erlangen Nuremberg, Germany
    Gut 35:1026-9. 1994
    In a prospective randomised study, the effect of acupuncture on sham feeding stimulated gastric acid secretion was investigated. In eight healthy volunteers (five men, three women, mean (SEM) age 26.3 (4...
  6. ncbi No potassium, no acid: K+ channels and gastric acid secretion
    Dirk Heitzmann
    Institute of Physiology, Regensburg, Germany
    Physiology (Bethesda) 22:335-41. 2007
    ..Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
  7. ncbi Different dosage regimens of rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotype status
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Pharmacol Ther 76:290-301. 2004
    ..0 for no more than 4 hours a day (<16.7%). We aimed to develop optimal dosage regimens for rabeprazole to control nocturnal acidity in relation to cytochrome P450 (CYP) 2C19 genotypes...
  8. ncbi In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents
    Sonia Mesia-Vela
    Natural Products Section, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, 04044 020 Rua 03 de Maio 100, Sao Paulo, SP, Brazil
    J Ethnopharmacol 111:403-8. 2007
    ..the hydrolysis of ATP by H(+),K(+)-ATPase with an IC(50) of 500 microg/ml, indicating that the inhibition of gastric acid secretion of Scoparia dulcis is related to the inhibition of the proton pump...
  9. ncbi Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice
    Laura Piqueras
    Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain
    Peptides 25:1287-95. 2004
    The role of somatostatin in galanin-induced inhibition of gastric acid secretion in urethane-anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 (SSTR2) knockout ..
  10. ncbi Considerations for long-term use of proton-pump inhibitors
    W R Garnett
    School of Pharmacy, Virginia Commonwealth University, Medical College of Virginia, Richmond 23298 0533, USA
    Am J Health Syst Pharm 55:2268-79. 1998
    ..PPIs are being used with increasing frequency to inhibit secretion of gastric acid in order to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcer disease...
  11. pmc Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens
    Sharon M Tennant
    Department of Microbiology and Immunology, The University of Melbourne, and Murdoch Children s Research Institute, Royal Children s Hospital, Victoria 3010, Australia
    Infect Immun 76:639-45. 2008
    Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there are almost no experimental data to support this hypothesis...
  12. ncbi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
    ..Also, the association of gastric mucosal protective function against HCl-challenge was compared between HSP72-induced and -reduced group...
  13. ncbi Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH
    Julia Kirchheiner
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Helmholtzstr 20, 89081 Ulm, Germany
    Eur J Clin Pharmacol 65:19-31. 2009
    ..Here we derived PPI dose equivalents based on a comprehensive assessment of dose-dependent effects on intragastric pH...
  14. pmc Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion
    Anders Smith
    Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Endocrinology 149:4554-66. 2008
    ..Gender-associated differences in basal, acid- and E2-stimulated DMBS may have offered a reasonable explanation for the clinically observed lower incidence of duodenal ulcer in premenopausal women than age-matched men...
  15. ncbi Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy
    Christina Reimer
    Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
    Gastroenterology 137:80-7, 87.e1. 2009
    ..Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI). If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications...
  16. ncbi The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH
    Yasunobu Abe
    The Third Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Gastroenterol 39:21-5. 2004
    ..The aim of our study was to investigate the inhibitory effects on gastric acid secretion after single intravenous administrations of omeprazole 20mg and famotidine 20 mg.
  17. pmc Pharmacology of proton pump inhibitors
    Jai Moo Shin
    Membrane Biology, David Geffen School of Medicine, University of California at Los Angeles, Room 324, Building 113, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 10:528-34. 2008
    ..PPIs with longer half-life promise to improve acid suppression. All PPIs give excellent healing of peptic ulcers and produce good results in reflux esophagitis. PPIs combined with antibiotics eradicate Helicobacter pylori...
  18. ncbi Comparison of lansoprazole and famotidine for gastric acid inhibition during the daytime and night-time in different CYP2C19 genotype groups
    N Shirai
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 16:837-46. 2002
    ..The acid inhibitory effect of lansoprazole depends on the S-mephenytoin 4'-hydroxylase (CYP2C19) genotype status. The effect of famotidine is independent of this genotype...
  19. ncbi IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin
    Meenakshi Chakravorty
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S C Mullick Road, Kolkata, India
    Int J Biochem Cell Biol 41:1502-10. 2009
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression...
  20. ncbi Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3
    Anand Rotte
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    J Gastroenterol 45:1022-32. 2010
    According to previous observations, basal gastric acid secretion is downregulated by phosphoinositol-3-(PI3)-kinase, phosphoinositide-dependent kinase (PDK1), and protein kinase B (PKBβ/Akt2) signaling...
  21. pmc Quantitative relation between gastric acid secretion and changes in urinary acid excretion
    C D Johnson
    Department of Surgery, Charing Cross and Westminster Medical School, St Stephen s Hospital, London
    Gut 31:862-6. 1990
    This study was designed to investigate the relations between gastric acid secretion and alkalinisation of the urine...
  22. pmc Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion
    Mohamad El-Zaatari
    Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 139:2061-2071.e2. 2010
    ....
  23. ncbi Influence of five neutralizing products on intra-oral pH after rinsing with simulated gastric acid
    Birgitta Lindquist
    Department of Cariology, Institute of Odontology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur J Oral Sci 119:301-4. 2011
    ..of various neutralizing products to raise the low intra-oral pH after an erosive exposure, in this case to gastric acid, which was simulated using hydrochloric acid (HCl). Eleven adults participated...
  24. ncbi Impact of esophageal bile exposure on the genesis of reflux esophagitis in the absence of gastric acid after total gastrectomy
    Takeyoshi Yumiba
    Department of Surgery, Osaka University Graduate School of Medicine, Japan
    Am J Gastroenterol 97:1647-52. 2002
    ..We aimed to assess the impact of esophageal bile exposure on the genesis of RE in reference to esophageal pH changes in the absence of gastric acid after total gastrectomy.
  25. ncbi Inhibitory effect of the cannabinoid receptor agonist WIN 55,212-2 on pentagastrin-induced gastric acid secretion in the anaesthetized rat
    G Coruzzi
    Institute of Pharmacology, Medical Faculty, University of Parma, Italy
    Naunyn Schmiedebergs Arch Pharmacol 360:715-8. 1999
    The effect of the cannabinoid (CB) receptor agonist WIN 55,212-2 on gastric acid secretion was studied in the anaesthetized rat after stimulation with pentagastrin. WIN 55,212-2 (0.5-2 mg/kg, i.v...
  26. ncbi Duodenal carbonic anhydrase: mucosal protection, luminal chemosensing, and gastric acid disposal
    Jonathan D Kaunitz
    Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA
    Keio J Med 55:96-106. 2006
    ..In this review, we will describe how luminal CO2/H+ traverses the duodenal epithelial cell brush border membrane, acidifies the cytoplasm, and is sensed in the subepithelium...
  27. ncbi A model for the study of Helicobacter pylori interaction with human gastric acid secretion
    Ian M Joseph
    Department of Microbiology and Immunology, The University of Michigan Medical School, 6730 Medical Science Building II, Ann Arbor, MI 48109 0620, USA
    J Theor Biol 228:55-80. 2004
    We present a comprehensive mathematical model describing Helicobacter pylori interaction with the human gastric acid secretion system...
  28. ncbi Gastric acid secretion in streptozotocin-diabetic female rats
    C Y Lin
    Department of Physiology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China
    Chin J Physiol 34:179-86. 1991
    The secretion of gastric acid in normal and streptozotocin-induced diabetic rats was studied. Female rats were injected with streptozotocin (64 mg/kg BW, iv) or vehicle...
  29. ncbi Inhibition of atazanavir oral absorption by lansoprazole gastric acid suppression in healthy volunteers
    Desiree L Tomilo
    School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, USA
    Pharmacotherapy 26:341-6. 2006
    ..To determine whether the pharmacokinetics of atazanavir, a protease inhibitor used to treat human immunodeficiency virus (HIV) infection, are altered by its coadministration with lansoprazole, a proton pump inhibitor...
  30. ncbi Influence of age and gender on gastric acid secretion as estimated by integrated acidity in patients referred for 24-hour ambulatory pH monitoring
    Grace L Shih
    Division of Gastroenterology, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:1713-8. 2003
    Earlier studies have suggested that gastric acid secretion declines with age...
  31. ncbi Intravenous and oral lansoprazole are equivalent in suppressing stimulated acid output in patient volunteers with erosive oesophagitis
    T O G Kovacs
    VA Greater Los Angeles Healthcare System, CURE Clinic, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 20:883-9. 2004
    ..Some patients requiring acid suppression may be unable to take oral medications...
  32. ncbi Evaluation of the effects of anti-secretory drugs on intragastric acidity: is combined therapy with a proton pump inhibitor and an H2 receptor antagonist effective as initial treatment?
    Masahiko Inamori
    J Gastroenterol 40:213-4. 2005
  33. ncbi Intravenous esomeprazole 40 mg vs. intravenous lansoprazole 30 mg for controlling intragastric acidity in healthy adults
    J R Pisegna
    David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 27:483-90. 2008
    ..Intravenous (IV) formulations of proton pump inhibitors are effective for patients in whom oral therapy is not appropriate...
  34. ncbi Somatostatin inhibits gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: a prospective, randomized, placebo-controlled trial
    Alec Avgerinos
    Second Department of Gastroenterology, Evangelismos Hospital, Athens, Greece
    Scand J Gastroenterol 40:515-22. 2005
    b>Gastric acid inhibition is beneficial in the management of peptic ulcer bleeding (PUB)...
  35. ncbi Endogenous neuropeptide Y depresses the afferent signaling of gastric acid challenge to the mouse brainstem via neuropeptide Y type Y2 and Y4 receptors
    T Wultsch
    Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Neuroscience 136:1097-107. 2005
    Vagal afferents signal gastric acid challenge to the nucleus tractus solitarii of the rat brainstem...
  36. ncbi Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat
    V Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Milano, Milan, Italy
    J Neuroendocrinol 18:122-8. 2006
    Ghrelin, the endogenous ligand of the GH secretagogue receptor (GHS-R) has been previously shown to inhibit gastric acid secretion in pylorus-ligated rats. Two isoforms of GHS-R have been identified: GHS-R(1a) and GHS-R(1b)...
  37. ncbi Central and peripheral regulation of gastric acid secretion by peptide YY
    Hong Yang
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, and Digestive Diseases Division, Department of Medicine and Brain Research Institute, University of California, Los Angeles, California 90073, USA
    Peptides 23:349-58. 2002
    ..released postprandially from the ileum and colon displays a potent inhibition of cephalic and gastric phases of gastric acid secretion through both central and peripheral mechanisms...
  38. ncbi Gastric acid reduction leads to an alteration in lower intestinal microflora
    Takayuki Kanno
    Department of Gastroenterology, Wakayama Medical University, Japan
    Biochem Biophys Res Commun 381:666-70. 2009
    To clarify the alterations in lower intestinal microflora induced by gastric acid reduction, the dynamics of 12 major genera or groups of bacteria comprising the microflora in feces and colonic contents were examined by quantitative real-..
  39. ncbi Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analog: gastric acid secretion, gastric mucosal damage and protection
    G Mozsik
    First Department of Medicine, Medical Faculty, University of Pecs, Hungary
    J Gastroenterol Hepatol 16:1093-7. 2001
    ..The possible roles of four stages of capsaicin-sensitive primary afferents can be evaluated in relation to gastric acid secretion, and to the details of the defensive side of gastric mucosa against different chemicals, physical ..
  40. ncbi A comparison of simplified lansoprazole suspension administered nasogastrically and pantoprazole administered intravenously: effects on 24-h intragastric pH
    J J Täubel
    Charterhouse Clinical Research Unit, London, UK
    Aliment Pharmacol Ther 15:1807-17. 2001
    ..To compare the 24-h intragastric pH effects of simplified lansoprazole suspension, 30 mg, administered nasogastrically, with pantoprazole, 40 mg, administered intravenously...
  41. ncbi Effects of a single dose of rabeprazole 20 mg and pantoprazole 40 mg on 24-h intragastric acidity and oesophageal acid exposure: a randomized study in gastro-oesophageal reflux disease patients with a history of nocturnal heartburn
    P Miner
    Oklahoma Foundation for Digestive Research, Oklahoma City, OK, USA
    Aliment Pharmacol Ther 31:991-1000. 2010
    ..Nocturnal heartburn is common in patients with gastro-oesophageal reflux disease (GERD)...
  42. pmc Early effects of oral administration of lafutidine with mosapride compared with lafutidine alone on intragastric pH values
    Hiroshi Iida
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    BMC Gastroenterol 9:52. 2009
    ..The aim of our study was to investigate the inhibitory effects on gastric acid secretion after a single oral administrations of lafutidine, is a newly synthesized H2-receptor antagonist, ..
  43. ncbi Pioglitazone induced gastric acid secretion
    Anand Rotte
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 24:193-200. 2009
    ..They enhance transcription of the serum and glucocorticoid inducible kinase SGK1, which could in turn enhance gastric acid secretion by stimulating KCNQ1 K+ channels...
  44. ncbi Control of 24-hour intragastric acidity with morning dosing of immediate-release and delayed-release proton pump inhibitors in patients with GERD
    Colin W Howden
    Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL60611, USA
    J Clin Gastroenterol 43:323-6. 2009
    ..To compare the effects of immediate-release omeprazole and 2 different delayed-release proton pump inhibitors on 24-hour intragastric acidity in gastroesophageal reflux disease patients...
  45. pmc Novel approaches to inhibition of gastric acid secretion
    George Sachs
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 12:437-47. 2010
    ..pylori eradication...
  46. ncbi Cisapride inhibits meal-stimulated gastric acid secretion and post-prandial gastric acidity in subjects with gastro-oesophageal reflux disease
    J D Gardner
    Science for Organizations, Inc, Chatham, NJ 07928, USA
    Aliment Pharmacol Ther 16:1819-29. 2002
    KCNQ1 potassium channels in human gastric parietal cells are thought to be involved in gastric acid secretion...
  47. ncbi Preoperative gastric acid secretion and the risk to develop Barrett's esophagus after esophagectomy for chagasic achalasia
    Julio Rafael Mariano da Rocha
    Digestive Surgery Division, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Gastrointest Surg 13:1893-8; discussion 1898-9. 2009
    ..The aim of this study was to determine the contribution of preoperative gastric secretory and hormonal response, to the appearance of Barrett's esophagus in the esophageal stump following subtotal esophagectomy...
  48. ncbi AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion
    Shafik Sidani
    Department of Surgery, Yale University, 310 Cedar Street, New Haven, CT 06511, USA
    Pflugers Arch 459:39-46. 2009
    ..We therefore propose the AMPK as a cellular metabolic off switch for gastric acid secretion.
  49. pmc Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial
    Matthew J Wright
    Department of Allied Health Sciences, University of Connecticut, Storrs, CT, USA
    J Bone Miner Res 25:2205-11. 2010
    Proton pump inhibitors (PPIs) are the most potent gastric acid suppressing drugs available, and their use is widespread...
  50. ncbi Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice
    W Goering
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Cytogenet Genome Res 121:88-95. 2008
    ..Although the parietal cell development is not affected in the absence of Foxq1, there is a lack of gastric acid secretion in response to various secretagogue stimuli...
  51. pmc Gastric acid hypersecretory states: recent insights and advances
    Nauramy Osefo
    Digestive Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9C 103, Bethesda, MD 20892, USA
    Curr Gastroenterol Rep 11:433-41. 2009
    b>Gastric acid hypersecretory states are characterized by basal hypersecretion of gastric acid and historically include disorders associated with hypergastrinemia, hyperhistaminemia, and those of unknown etiology...
  52. ncbi Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells
    Hirofumi Matsui
    The Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Gastroenterol 46:1167-76. 2011
    ..We hypothesized that gastric acid may disrupt mitochondrial transmembrane potential and induce the production of superoxide in mitochondria, ..
  53. ncbi Solanum paniculatum L. (Jurubeba): potent inhibitor of gastric acid secretion in mice
    S Mesia-Vela
    Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil
    Phytomedicine 9:508-14. 2002
    ..the plant (flowers, fruits, leaves, stems and roots) were tested to determine their antiulcer and antisecretory gastric acid activities using mice...
  54. ncbi Low gastric acid and high plasma gastrin in high-anxiety Wistar Kyoto rats
    Malin Florentzson
    AstraZeneca R and D, Molndal, Sweden
    Scand J Gastroenterol 44:401-7. 2009
    ..We have already demonstrated that gastrin cells are more active and ghrelin cells less active in WKY rats than in SPD rats. The purpose of this study was to compare endocrine cell activity and gastric acid output in WKY and SPD rats.
  55. ncbi Multi-parametric approach to identify coffee components that regulate mechanisms of gastric acid secretion
    Malte Rubach
    German Research Center for Food Chemistry, Freising, Germany
    Mol Nutr Food Res 56:325-35. 2012
    ..CAFF), pyrogallol (PYR), catechol (CAT), (β)N-alkanoyl-hydroxytryptamides (C5HT) and N-methylpyridinium (N-MP) were evaluated for their influence on mechanisms of gastric acid secretion as single compounds and in biomimetic mixtures.
  56. ncbi Measurement of meal-stimulated gastric acid secretion by in vivo gastric autotitration
    Jerry D Gardner
    Science for Organizations, Inc, Chatham, New Jersey 07928, USA
    J Appl Physiol (1985) 92:427-34. 2002
    Measurement of meal- stimulated gastric acid secretion using manual intragastric titration is demanding in terms of personnel and specialized equipment...
  57. ncbi Pentagastrin-induced gastric acid secretion in the diabetic rats: role of insulin
    Full Young Chang
    Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Chin J Physiol 47:175-81. 2004
    ..This effect appears to be responsible for the excessive acid output of diabetic rats undergoing pentagastrin stimulation...
  58. ncbi Omeprazole: its influence on gastric acid secretion, gastrin and ECL cells
    H Larsson
    Department of Biology, AB Hässle, Molndal, Sweden
    Toxicol Pathol 16:267-72. 1988
    ..The hypothesis may be outlined as follows: 1) Inhibition of gastric acid secretion leads to elevated antral pH and, secondarily, to release of gastrin from the antral gastrin cells ..
  59. pmc Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine
    Martin E Edelsbrunner
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    BMC Gastroenterol 9:40. 2009
    ..The present study investigated whether intragastric administration of lafutidine (10 and 30 mg/kg) modifies vagal afferent signalling, mucosal injury, intragastric acidity and gastric emptying after gastric acid challenge.
  60. pmc Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness
    Stephen Brett
    Department of Anaesthetics and Intensive Care, Hammersmith Hospital, London, UK
    Crit Care 9:45-50. 2005
    ..This review seeks to present the pharmacological evidence that may inform decision-making about the prescription of drugs for prophylaxis of SRMD...
  61. ncbi Acid suppression in healthy subjects following lansoprazole or pantoprazole
    J Q Huang
    McMaster University, Hamilton, Ont, Canada
    Aliment Pharmacol Ther 16:425-33. 2002
    To compare the effect of lansoprazole, 30 mg once daily, with that of pantoprazole, 40 mg once daily, for the inhibition of gastric acid secretion.
  62. pmc Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats
    Ze Feng Xia
    Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Physiol Gastrointest Liver Physiol 303:G570-7. 2012
    ..The effects of nesfatin-1 on gastrointestinal secretory function, including gastric acid production, have not been evaluated...
  63. ncbi Gastric acid is the key modulator in the pathogenesis of non-steroidal anti-inflammatory drug-induced ulceration in rats
    J Michael Zinkievich
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Exp Pharmacol Physiol 37:654-61. 2010
    1. In the present study, we investigated the role of gastric acid (GA) secretion on non-steroidal anti-inflammatory drug (NSAID)-induced ulcerogenesis in vivo...
  64. ncbi The acetone soluble fraction from bark extract of Stryphnodendron adstringens (Mart.) coville inhibits gastric acid secretion and experimental gastric ulceration in rats
    D T O Martins
    Departamento de Ciëncias Básicas em Saúde FCM, Universidade Federal de Mato Grosso, 78060 900 Cuiabá MT, Brazil
    Phytother Res 16:427-31. 2002
    ..and chronic (acetic acid) models of gastric ulceration and on basal and bethanechol-stimulated gastric acid secretion in rats...
  65. ncbi Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system
    T Okumura
    Third Department of Internal Medicine, Asahikawa Medical College, Japan
    Endocrinology 141:2854-60. 2000
    ..Food consumption, gastric acid secretion, and gastric emptying were measured after injection of CART into the cerebrospinal fluid in 24-h ..
  66. pmc Somatostatin receptor type 2 mediates bombesin-induced inhibition of gastric acid secretion in mice
    Laura Piqueras
    Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain
    J Physiol 549:889-901. 2003
    ..We characterized the effects of exogenous bombesin on gastric acid secretion in mice and determined the involvement of somatostatin and somatostatin receptor type 2 (SSTR2) by ..
  67. ncbi Low-dose intravenous pantoprazole for optimal inhibition of gastric acid in Korean patients
    Jung Hwan Oh
    Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Gastroenterol Hepatol 22:1429-34. 2007
    ..The aim of this study was to evaluate the efficacy of various doses of pantoprazole on intragastric acidity in Korean patients...
  68. ncbi Functional role of protein kinase B/Akt in gastric acid secretion
    A Todisco
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 276:46436-44. 2001
    Epidermal growth factor (EGF) stimulates gastric acid secretion and H(+)/K(+)-ATPase alpha-subunit gene expression. Because EGF activates the serine-threonine protein kinase Akt, we explored the role of Akt in gastric acid secretion...
  69. ncbi Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain
    Sachie Minowa
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Brain Res 1039:75-83. 2005
    The activation of transient receptor potential vanilloid receptor 1 (TRPV1) by capsaicin in rat brain stimulates gastric acid secretion via tachykinin NK2 receptors and the vagus cholinergic nerve, but the involvement of other receptor ..
  70. ncbi Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain
    T Michl
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010, Graz, Austria
    Pain 92:19-27. 2001
    Although gastric acid is a factor in upper abdominal pain, the signaling and processing of a gastric mucosal acid insult within the brain are not known...
  71. pmc Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole
    Hatsushi Yamagishi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 9808574, Japan
    World J Gastroenterol 14:2406-10. 2008
    ..To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg...
  72. ncbi Secretagogue-specific effects of interleukin-1 on gastric acid secretion
    J L Wallace
    Gastrointestinal Research Group, University of Calgary, Alberta, Canada
    Am J Physiol 261:G559-64. 1991
    ..Also, the effects of IL-1 beta on gastric acid secretion stimulated by bethanechol or histamine were assessed...
  73. ncbi Impaired gastric acid secretion in gastrin-deficient mice
    L Friis-Hansen
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 274:G561-8. 1998
    ..However, gastric function was severely affected by the loss of gastrin. Basal gastric acid secretion was abolished and could not be induced by histamine, carbachol, or gastrin...
  74. ncbi Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms?
    P G Farup
    Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway
    J Clin Gastroenterol 33:206-9. 2001
    ..Rebound acid hypersecretion might occur after treatment with proton pump inhibitors. This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole...
  75. ncbi Function of GABAergic and glutamatergic neurons in the stomach
    Li Hsueh Tsai
    Department of Physiology, School of Medicine, Taipei Medical University, Taipei, 11014, Taiwan
    J Biomed Sci 12:255-66. 2005
    ..GABA and L-Glu may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors and glutamate receptors presents potential new target sites for drug development...
  76. ncbi Heterogeneity of acid secretion induced by carbachol and histamine along the gastric gland axis and its relationship to [Ca2+]i
    Jose Francisco Perez-Zoghbi
    Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Am J Physiol Gastrointest Liver Physiol 295:G671-81. 2008
    ..2, both triggered by Ca(2+) release. Maintenance of acid secretion depends on Ca(2+) entry and perhaps membrane fusion...
  77. ncbi Insights into the future of gastric acid suppression
    Kenneth R DeVault
    Department of Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32233, USA
    Nat Rev Gastroenterol Hepatol 6:524-32. 2009
    ..Although these agents could potentially achieve complete gastric acid suppression, risks may be associated with this level of suppression, including enteric infections and ..
  78. ncbi Esomeprazole therapy for gastric acid hypersecretion in children with cystinosis
    Ranjan Dohil
    UCSD Medical Center, San Diego, CA 92103 8450, USA
    Pediatr Nephrol 20:1786-93. 2005
    ..disease progression in children with cystinosis, but it may cause severe gastrointestinal (GI) symptoms through gastric acid-hypersecretion...
  79. ncbi An open-label, parallel, multiple-dose study comparing the pharmacokinetics and gastric acid suppression of rabeprazole extended-release with esomeprazole 40 mg and rabeprazole delayed-release 20 mg in healthy volunteers
    G Morelli
    St Mary s Hospital, McGill University, Westmount, Montreal, QC, Canada
    Aliment Pharmacol Ther 33:845-54. 2011
    Novel rabeprazole extended-release (ER) formulations were developed to provide prolonged gastric acid suppression and potentially improved clinical outcomes in GERD patients.
  80. ncbi Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint
    Helge L Waldum
    Department of Gastroenterology and Liver Diseases, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Scand J Gastroenterol 45:389-94. 2010
    ..The aim of this paper is to review current knowledge of the regulation of gastric acid secretion, including maximal acid secretion, and to improve understanding of the pathogenesis of acid-related ..
  81. pmc Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7006, Trondheim, Norway
    Endocrinology 149:498-505. 2008
    ..ECL) cell-parietal cell axis is known to play an important role in the regulation of gastric acid secretion...
  82. pmc Gastric acid secretion in aquaporin-4 knockout mice
    K S Wang
    Department of Surgery, Stanford University, CA 94305 5655, USA
    Am J Physiol Gastrointest Liver Physiol 279:G448-53. 2000
    The aquaporin-4 (AQP4) water channel has been proposed to play a role in gastric acid secretion...
  83. ncbi Effect of age and Helicobacter pylori infection on gastric acid secretion
    K Haruma
    First Department of Internal Medicine, Hiroshima University School of Medicine, Kasumi, Japan
    J Gastroenterol Hepatol 15:277-83. 2000
    Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori, the association of this bacterium with gastric acid secretion has also been discussed...
  84. ncbi Increased gastric acid secretion after Helicobacter pylori eradication may be a factor for developing reflux oesophagitis
    T Koike
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Aliment Pharmacol Ther 15:813-20. 2001
    ..The role of acid secretion in reflux oesophagitis which may develop after H. pylori eradication is not well known...
  85. ncbi Rabeprazole is superior to omeprazole for the inhibition of peptone meal-stimulated gastric acid secretion in Helicobacter pylori-negative subjects
    G V Ohning
    Research and Medical Services, Department of Veteran Affairs, VA GLAHS West Los Angeles Healthcare Center, and the Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 17:1109-14. 2003
    Peptone meal-stimulated gastric acid output is considered to be a reliable means to evaluate drug-mediated inhibition of stimulated gastric acid output, an important measure of the efficacy of the agents--such as proton pump inhibitors--..
  86. ncbi Gastric acid inhibition for fat malabsorption or gastroesophageal reflux disease in cystic fibrosis: longitudinal effect on bacterial colonization and pulmonary function
    Hubert P J van der Doef
    Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Pediatr 155:629-33. 2009
    To investigate bacterial colonization and pulmonary function longitudinally in patients with cystic fibrosis (CF) receiving drugs for gastric acid (GA) inhibition for fat malabsorption or for gastroesophageal reflux disease (GERD).
  87. pmc Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion
    Guanglin Cui
    Laboratory of Gastroenterology, Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, Tromsø N 9037, Norway
    World J Gastroenterol 13:493-6. 2007
    b>Gastric acid plays an important role in digesting food (especially protein), iron absorption, and destroying swallowed micro-organisms...
  88. ncbi Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication
    Katsunori Iijima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Gastroenterol 44:819-25. 2009
    The measurement of serum pepsinogens is clinically useful to represent gastric acid secretion. Since both serum pepsinogens and gastric acid secretion are considerably altered by H...
  89. pmc Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice
    Laura Piqueras
    Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain
    Br J Pharmacol 142:67-78. 2004
    1. Studies in rats suggest that PACAP modulates gastric acid secretion through the release of both histamine and somatostatin. 2...
  90. ncbi Systematic review: Rebound acid hypersecretion after therapy with proton pump inhibitors
    N G M Hunfeld
    Central Hospital Pharmacy, The Hague, The Netherlands
    Aliment Pharmacol Ther 25:39-46. 2007
    ..The occurrence and the clinical relevance of rebound acid hypersecretion after discontinuation of proton pump inhibitors is unclear...
  91. ncbi Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion
    Nils W G Lambrecht
    Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Physiol Genomics 21:81-91. 2005
    ..KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.
  92. ncbi Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells
    Andrea Gerbino
    Department of Surgery, Brigham and Women s Hospital, VA Boston Health Care System, Boston, MA 02115, USA
    Gastroenterology 126:182-95. 2004
    ..Background &..
  93. pmc Histamine dependence of pentagastrin-stimulated gastric acid secretion in rats
    N P Shankley
    James Black Foundation, London, United Kingdom
    Yale J Biol Med 65:613-9. 1992
    Does gastrin stimulate gastric acid secretion by direct action on oxyntic cells, by releasing histamine, or by being potentiated by histamine? Previous studies in the mouse pointed to gastrin-regulated histamine release...
  94. ncbi Bedtime H2 blockers improve nocturnal gastric acid control in GERD patients on proton pump inhibitors
    S Xue
    The Graduate Hospital, Philadelphia, PA 19146, USA
    Aliment Pharmacol Ther 15:1351-6. 2001
    ..d. AC) effectively controls daytime gastric pH; however, nocturnal gastric acid breakthrough (NAB) occurs in more than 75% of patients...
  95. ncbi PACAP stimulates gastric acid secretion in the rat by inducing histamine release
    A K Sandvik
    Department of Physiology and Biomedical Engineering, University Hospital of Trondheim, Faculty of Medicine, The Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Am J Physiol Gastrointest Liver Physiol 281:G997-G1003. 2001
    ..PACAP) stimulates enterochromaffin-like (ECL) cell histamine release, but its role in the regulation of gastric acid secretion is disputed...
  96. ncbi The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
    Gastroenterology 134:696-705. 2008
    ..We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD...
  97. ncbi Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study
    Philip Miner
    Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, 711 Stanton L Young Boulevard, Suite 619, Oklahoma City, OK 73104, USA
    Am J Gastroenterol 98:2616-20. 2003
    Proton pump inhibitors owe their clinical efficacy to their ability to suppress gastric acid production...
  98. ncbi L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
    Stephanie M Busque
    Dept of Surgery, Yale University, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 289:G664-9. 2005
    ..These data support the conclusion that amino acids, in conjunction with a physiological Ca(o)(2+) concentration, can induce acid secretion independent of hormonal stimulation via allosteric activation of the stomach CaSR...
  99. ncbi The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands
    Matthias M Dufner
    Institute of Physiology, University of Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 289:G1084-90. 2005
    b>Gastric acid secretion is activated by two distinct pathways: a neuronal pathway via the vagus nerve and release of acetylcholine and an endocrine pathway involving gastrin and histamine...
  100. ncbi Association between gastric acid and mucin secretion in dyspeptic patients
    Y Niv
    Department of Gastroenterology, Beilinson Campus, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel
    Digestion 65:141-8. 2002
    ..The maintenance of an intact gastric mucosa implies a balance between aggressive, such as acid, and protective factors such as mucin. We examined gastric aspirates to determine a possible correlation between gastric acid and mucin contents.
  101. ncbi Comparison of morning and evening administration of rabeprazole for gastro-oesophageal reflux and nocturnal gastric acid breakthrough in patients with reflux disease: a double-blind, cross-over study
    N D Pehlivanov
    Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    Aliment Pharmacol Ther 18:883-90. 2003
    To assess the effect of timing of rebeprazole (RB) 20 mg/d administration on oesophageal acid exposure and nocturnal gastric acid breakthrough (NGAB) in patients with GERD.

Research Grants62

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..breath pH, the studies will focus on distinguishing between patients with primary airway acidification and gastric acid aspiration...
  2. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA J SILVA BENITEZ; Fiscal Year: 2010
    ..The bacterium is transmitted person-to-person by the fecal oral route. Infecting Vibrios that overcome the gastric acid barrier swim toward and adhere to the intestinal mucosa and express major virulence factors such as the toxin ..
  3. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: H. pylori is a gastric carcinogen that facilitates gastric colonization by inhibiting gastric acid secretion. This proposal addresses the molecular basis of acid inhibition by H. pylori...
  4. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..Local airway trauma secondary to accidental aspiration of gastric acid is a frequent cause of acute lung injury and acute respiratory distress syndrome with neutrophil (PMN) - ..
  5. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2012
    ..and mutant mouse models lacking NHE3, NHE2, or the gastric H+/K+-ATPase will permit us to evaluate the roles of gastric acid and the intestinal brush-border acidic microclimate in providing the H+ to drive DMT1-mediated Fe2+ transport...
  6. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..Sour taste receptors detect a decrease in intracellular pH, but in the case of strong acids such as gastric acid (HCI) the mechanism by which protons enter taste cells remains unknown...
  7. Role of Acid in the Development of Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2013
    ..Modern medical therapy of GERD is directed almost exclusively at decreasing gastric acid production with medications such as proton pump inhibitors (PPIs)...
  8. Calcium Sensing Receptor Signaling in the Gastrointestinal Tract
    Osvaldo Rey; Fiscal Year: 2009
    ..the CaR is a signal transducer of great biological importance implicated in the control of Ca2+ homeostasis, gastric acid secretion, intestinal transport, homing of embryonic cells and in the progression and spread of colorectal, ..
  9. The Role of IL-6/STAT3 in the Pathogenesis and Progression of Barrett's Esophagus
    Ronnie Fass; Fiscal Year: 2012
    ..Bile and gastric acid in the refluxate are two of the major factors involved in the pathogenesis of BE...
  10. Genetic Models for Disorders of Acid-Base Transport
    GARY EDWARD SHULL; Fiscal Year: 2013
    ..In coupled systems, they mediate gastric acid secretion;maintain fluidity and pH of lumenal contents in intestine;recover ions and water in colon;and control ..
  11. Evaluating Clostridium difficile Infection in Hospitalized Patients
    AMY LYNN PAKYZ; Fiscal Year: 2013
    ..difficile. Antibiotic and gastric acid suppressant therapy and infection control polices are regarded as the main risk factors for C...
  12. Toll-like Receptor Signaling in the Esophageal Epithelium
    Mei Lun Wang; Fiscal Year: 2013
    ..It is known that prolonged exposure to gastric acid leads to esophageal injury, resulting in cell necrosis in the stratum spinosum of the esophageal epithelium...
  13. RESULT Trial-REflux SUrgery in Lung Transplantation
    Scott M Palmer; Fiscal Year: 2011
    ..reflux disease (GERD) who will be randomized to either receive medical management focusing on preventing gastric acid production or to undergo surgical fundoplication focusing on preventing GERD related aspiration environmental ..
  14. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2013
    ..However, there is no consistent abnormality of gastric acid secretion in GERD and this management strategy has led to the substantial and costly overuse of these ..
  15. Duodenal Mucosal Defense Mechanisms
    Jonathan D Kaunitz; Fiscal Year: 2013
    ..Although the 'gastric acid barrier'effectively reduces bacterial counts in the stomach, many bacterial species can escape this ..
  16. AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTION
    Aryeh Hurwitz; Fiscal Year: 1993
    ..b>Gastric acid displaces the quinine, which is then absorbed and excreted in the urine...
  17. Sphingolipid and Mechanism of Cyst Formation by Giardia
    Siddhartha Das; Fiscal Year: 2013
    ..Exposures of cysts to gastric acid during passage through the human stomach trigger excystation, while factors in the small intestine, where ..
  18. GASTRIC ACID SECRETION AND BUFFER CONTENT AFTER EATING
    Mark Feldman; Fiscal Year: 1991
    ..The specific goals of the research described in this application are to study mechanisms of gastric acid secretion and release of hormones that regulate acid secretion in humans with, or without, peptic ulcer disease;..
  19. Adaptive immune mechanism in acute H. pylori infection
    John Kao; Fiscal Year: 2009
    Helicobacter pylori is a highly adaptive pathogen that escapes host bacterial defenses (i.e., gastric acid and humoral immunity) leading to chronic infection...
  20. The function of ezrin in stimulus-coupled acid secretion
    Xuebiao Yao; Fiscal Year: 2012
    ..However, little is known regarding the molecular mechanism(s) by which ezrin operates in gastric acid secretion...
  21. NON-GASTRIN SECRETAGOGUE PEPTIDE IN ISLET CELL TUMORS
    William Chey; Fiscal Year: 1999
    ..This peptide was found during investigation of 44 patients with islet cell tumor with gastric acid hypersecretion and peptic ulceration...
  22. Study of Acid Reflux Therapy for Children with Asthma
    Janet T Holbrook; Fiscal Year: 2010
    ..Children with asthma are often treated for GER with drugs to suppress gastric acid production. However, this treatment is expensive, and with unproven benefit...
  23. STRUCTURE AND ROLE(S) OF GASTRIC AND THYMIC PEPTIDES
    Robert Carraway; Fiscal Year: 1980
    ..to potently affect the intestinal vascular bed of the conscious dog and also to inhibit pentagastrin-induced gastric acid secretion in dogs with Pavlov pouches...
  24. NON-GASTRIN ACID SECRETAGOGUE IN ISLET CELL TUMORS
    William Chey; Fiscal Year: 1990
    In a group of patients with pancreatic islet cell neoplasms, marked gastric acid hypersecretion and peptic ulceration and/or diarrhea, normal plasma concentrations of gastrin were found...
  25. GASTRIC H+ ION TRANSPORT--CELLULAR CONTROL MECHANISMS
    CATHERINE CHEW; Fiscal Year: 1999
    ..Peptic ulcer disease is a widespread clinical problem that results from or is exacerbated by gastric acid secretion...
  26. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2004
    ..important physiologic actions of GRP in the gastrointestinal tract, such as pancreatic enzyme secretion and gastric acid secretion, the hGRP-R also mediates signals of proliferation and differentiation in human intestinal and ..
  27. CHEMISTRY AND BIOLOGY OF GUT PANCREASTATIN
    JOHN DELVALLE; Fiscal Year: 1992
    ..Thus pancreastatin may have physiological importance in regulating gastric acid secretion through unique mechanisms...
  28. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    ..To colonize the intestinal tract, C. jejuni must successfully transit through the gastric acid barrier of the stomach to the more alkaline environment of the intestine...
  29. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ..Experiments will be performed in conscious or anesthetized rats to monitor gastric acid secretion, motility and mucosal blood flow and/or resistance of the mucosa to gastric injury...
  30. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
    ..cells in gastric mucosa are controlled by neuropeptides and participate in the regulatory mechanism of gastric acid secretion; 4) The release of CCK from pancreatic islets is neurally regulated and participates in regulation of ..
  31. METALLOPROTEINASES IN VENTILATOR-INDUCED LUNG INJURY
    Hussein Foda; Fiscal Year: 2003
    Acute, diffuse lung injury often complicates sepsis, gastric acid aspiration, extensive trauma, drug overdose, and other conditions...
  32. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2004
    ..GRP-R) and elicits important physiologic actions in the gastrointestinal tract, such as pancreatic enzyme and gastric acid secretion...
  33. FORMATION, STORAGE, AND RELEASE OF GASTRIC ACID
    E Ekblad; Fiscal Year: 1990
    The hypothesis is that gastric acid secretion may involve two separate steps, viz. formation of "acid" (protons, buffered protons or an enzyme) that is stored in an intracellular compartment and translocation (i.e...
  34. GASTRIC ACID SECRETION: CATION BINDING IN H,K-ATPASE
    EDWIN RABON; Fiscal Year: 2000
    ..This proposal focuses on the identification of charged residues within the transmembrane domain that are necessary for cation binding and the elucidation of the contribution of the beta-subunit to cation binding. ..
  35. IMMUNOLOGY OF CAMPYLOBACTOR PYLORI IN GASTRIC DISEASE
    Steven Czinn; Fiscal Year: 1992
    ..Therapy directed at inhibiting gastric acid secretion allows for short term resolution of symptoms and healing of ulcers; however, the relapse rate remains ..
  36. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007
    ..Poorly controlled asthmatics are often treated for GERD with drugs that suppress gastric acid, but this treatment is expensive and the benefit of such treatment is not established...
  37. REGULATION OF CARBONIC ANHYDRASE II GENE EXPRESSION
    LUCYNDIA MARINO; Fiscal Year: 1993
    The production of gastric acid is dependent of the function of an enzyme, H+ K+ ATPase, that is capable of pumping protons into a secretory canaliculus against a 6-log concentration gradient...
  38. MOLECULAR MECHANISM OF ACTION OF SOMATOSTATIN
    Andrea Todisco; Fiscal Year: 1999
    ..of somatostatin is paralleled precisely by the ability of the hormone to inhibit both cell proliferation and gastric acid secretion...
  39. CHLORIDE CHANNELS AND GASTRIC ACID SECRETION
    John Cuppoletti; Fiscal Year: 2003
    ..These studies strive to address the fundamental questions regarding the molecules and mechanisms involved in regulated HCl secretion. ..
  40. IRON & VITAMIN A DEFICIENCY IN CHILDREN DUE TO H. PYLORI
    MOHAMMAD KHALED; Fiscal Year: 2000
    ..pylori) infection induces hypochlorohydria/achlorohydria in the stomach. Gastric acid is considered as an important luminal factor in the absorption of food/non-heme iron and many other micro-..
  41. MECHANISMS AND CONTROL OF ACID RESISTANCE IN E COLI
    John Foster; Fiscal Year: 2004
    DESCRIPTION (Adapted from applicant's abstract): The gastric acid barrier presents a major obstacle to enteric pathogens and, as a result, is considered a key has strategy for preventing gastrointestinal infections...
  42. NOVEL SECRETIN RECEPTOR INTERACTING PROTEINS
    Michael Shetzline; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Secretin modulates gastric acid release, intestinal motility and pancreatic water and bicarbonate secretion leading to neutralization of acidic chyme...
  43. EGF GENE REGULATION IN KIDNEY AND SUBMANDIBULAR GLAND
    RUTH GUBITS; Fiscal Year: 1990
    ..of premature eyelid opening and incisor eruption, the maturation of the lung and trachya, and the inhibition of gastric acid secretion. These potent biological activities are also produced by urogastrone, the human analog of mouse EGF...
  44. ISOLATION OF THE INTESTINAL PHASE HORMONE
    MARSHALL ORLOFF; Fiscal Year: 1980
    The existence of a stimulatory intestinal phase of gastric acid secretion has been suspected, although largely ignored, for many years...
  45. VACCINE DELIVERY SYSTEM FOR LIVE ROTAVIRUS VACCINES
    Miroslav Novak; Fiscal Year: 1992
    ..In order to avoid the inactivation of virus by gastric acid, different buffers are being given before vaccination in current vaccine trials...
  46. SYNTHESIS AND BIOLOGY OF ANALOGS OF SOMATOSTATIN
    David Coy; Fiscal Year: 1990
    ..somatostatin analogs with increased activities and selectivity for inhibition of glucagon, growth hormone, and gastric acid secretion...
  47. CHRONOBIOLOGY AND GASTROINTESTINAL ENDOCRINOLOGY
    PHILIP RAYFORD; Fiscal Year: 1993
    ..will be conducted with isolated parietal cells to study circadian effects of specific agonist and antagonist on gastric acid secretion...
  48. Novel Method for Mucosal Delivery of Protein Drugs
    Keith Mostov; Fiscal Year: 2004
    ..It was formerly believed that the principal problem was due to denaturation of the proteins by gastric acid and digestion by gastrointestinal proteases...
  49. PHYSIOLOGICAL REGULATION OF GASTRIN GENE EXPRESSION
    Stephen Brand; Fiscal Year: 1992
    Gastrin secreted from antral G cells is the major hormonal regulator of gastric acid secretion...
  50. REGULATION OF VESICULAR NEUROTRANSMITTER TRANSPORT IN D*
    David Krantz; Fiscal Year: 2002
    Monoamine neurotransmitters including histamine regulate multiple physiological processes, including gastric acid secretion in humans. In Drosophila, histamine mediates photoreceptor synaptic transmission...
  51. GASTRIC ACID SECRETION
    George Sachs; Fiscal Year: 1992
    ..With these methods, a model will be derived that integrates the electrophysiology, morphology, and biochemical of the membrane processes involved in the transition from rest to secretion...
  52. Hydrogen/Potassium Atpase and Gastric Acid Secretion
    Danielle Smith; Fiscal Year: 2005
    DESCRIPTION (provided by applicant) Gastric acid secretion contributes to ulcer formation and its control is one of the primary targets of pharmacologic agents employed to promote ulcer healing...
  53. MOLECULAR BASIS OF SECRETIN RECEPTOR REGULATION
    Michael Shetzline; Fiscal Year: 2002
    Secretin modulates gastric acid release, intestinal motility and pancreatic water and bicarbonate secretion leading to neutraliza-tion of acidic chyme...
  54. THIRD CONFERENCE ON GASTRIN
    Juanita Merchant; Fiscal Year: 1999
    Gastrin is a regulatory peptide expressed in adult antrum. Hypergastrinemic states correlate with gastric acid hypersecretion that result in duodenal ulcerations...
  55. AIRWAY PROTECTION AGAINST ASPIRATION OF GASTRIC CONTENT
    Reza Shaker; Fiscal Year: 2002
    ..by the pulmonary structures, the defense mechanisms of the alveolar and bronchial linings against aspirated gastric acid remains unclear...
  56. HORMONAL REGULATION OF ISOLATED GASTRIC MUCOSAL CELLS
    Gary Rosenfeld; Fiscal Year: 1980
    The main objective of this research is to understand how gastric acid secretagogues and secretory inhibitors regulate the secretion of hydrogen ions in the stomach...
  57. A Breath Test to Detect Bacterial Overgrowth in Elderly
    David Wagner; Fiscal Year: 2003
    ..The underlying cause is reduced gastric acid secretion associated with aging...
  58. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Inhibition of gastric acid secretion is a major focus for therapy of acid-related diseases such as GERD, PUD and in combination with antibiotics, eradication of H. pylori...
  59. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The gastric H+, K+ ATPase catalyzes the final step of gastric acid secretion thereby generating a proton gradient across the canalicular membrane of greater than a million fold...
  60. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    b>Gastric acid secretion is a major factor in causation of GERD and peptic ulcer disease. H. pylori modifies secretion of gastrin and somatostatin and is also a major contributor to ulcerogenesis...
  61. A MICROSURGICAL INVESTIGATION OF GASTRIC ACID SECRETION
    John Geibel; Fiscal Year: 2004
    ..abstract_text> ..