gastric acid

Summary

Summary: Hydrochloric acid present in GASTRIC JUICE.

Top Publications

  1. ncbi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
  2. ncbi Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens
    Sharon M Tennant
    Department of Microbiology and Immunology, The University of Melbourne, and Murdoch Children s Research Institute, Royal Children s Hospital, Victoria 3010, Australia
    Infect Immun 76:639-45. 2008
  3. ncbi IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin
    Meenakshi Chakravorty
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S C Mullick Road, Kolkata, India
    Int J Biochem Cell Biol 41:1502-10. 2009
  4. ncbi Impaired gastric acid secretion in gastrin-deficient mice
    L Friis-Hansen
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 274:G561-8. 1998
  5. ncbi Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms?
    P G Farup
    Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway
    J Clin Gastroenterol 33:206-9. 2001
  6. ncbi Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole
    Hatsushi Yamagishi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 9808574, Japan
    World J Gastroenterol 14:2406-10. 2008
  7. ncbi Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain
    T Michl
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010, Graz, Austria
    Pain 92:19-27. 2001
  8. ncbi Function of GABAergic and glutamatergic neurons in the stomach
    Li Hsueh Tsai
    Department of Physiology, School of Medicine, Taipei Medical University, Taipei, 11014, Taiwan
    J Biomed Sci 12:255-66. 2005
  9. ncbi Secretagogue-specific effects of interleukin-1 on gastric acid secretion
    J L Wallace
    Gastrointestinal Research Group, University of Calgary, Alberta, Canada
    Am J Physiol 261:G559-64. 1991
  10. ncbi Bedtime H2 blockers improve nocturnal gastric acid control in GERD patients on proton pump inhibitors
    S Xue
    The Graduate Hospital, Philadelphia, PA 19146, USA
    Aliment Pharmacol Ther 15:1351-6. 2001

Research Grants

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
  2. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2010
  3. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2009
  4. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2009
  5. Toll-like Receptor Signaling in the Esophageal Epithelium
    Mei Lun Wang; Fiscal Year: 2010
  6. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 2007
  7. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
  8. SENSING PH AT THE GASTRIC SURFACE
    Marshall Montrose; Fiscal Year: 2003
  9. SECRETIN & GASTRIC MOTILITY IN HEALTH & DUODENAL ULCERS
    Chung Owyang; Fiscal Year: 1993
  10. CELL BIOLOGY OF ION PUMPS SORTING AND FUNCTION
    Michael Caplan; Fiscal Year: 2000

Detail Information

Publications283 found, 100 shown here

  1. ncbi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection
    Isao Wada
    Department of Internal Medicine and Gastroenterology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 349:611-8. 2006
    ..Also, the association of gastric mucosal protective function against HCl-challenge was compared between HSP72-induced and -reduced group...
  2. ncbi Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens
    Sharon M Tennant
    Department of Microbiology and Immunology, The University of Melbourne, and Murdoch Children s Research Institute, Royal Children s Hospital, Victoria 3010, Australia
    Infect Immun 76:639-45. 2008
    Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there are almost no experimental data to support this hypothesis...
  3. ncbi IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin
    Meenakshi Chakravorty
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S C Mullick Road, Kolkata, India
    Int J Biochem Cell Biol 41:1502-10. 2009
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression...
  4. ncbi Impaired gastric acid secretion in gastrin-deficient mice
    L Friis-Hansen
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 274:G561-8. 1998
    ..However, gastric function was severely affected by the loss of gastrin. Basal gastric acid secretion was abolished and could not be induced by histamine, carbachol, or gastrin...
  5. ncbi Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms?
    P G Farup
    Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway
    J Clin Gastroenterol 33:206-9. 2001
    ..Rebound acid hypersecretion might occur after treatment with proton pump inhibitors. This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole...
  6. ncbi Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole
    Hatsushi Yamagishi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryou Machi, Aobaku, Sendai 9808574, Japan
    World J Gastroenterol 14:2406-10. 2008
    ..To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg...
  7. ncbi Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain
    T Michl
    Department of Experimental and Clinical Pharmacology, University of Graz, , A-8010, Graz, Austria
    Pain 92:19-27. 2001
    Although gastric acid is a factor in upper abdominal pain, the signaling and processing of a gastric mucosal acid insult within the brain are not known...
  8. ncbi Function of GABAergic and glutamatergic neurons in the stomach
    Li Hsueh Tsai
    Department of Physiology, School of Medicine, Taipei Medical University, Taipei, 11014, Taiwan
    J Biomed Sci 12:255-66. 2005
    ..GABA and L-Glu may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors and glutamate receptors presents potential new target sites for drug development...
  9. ncbi Secretagogue-specific effects of interleukin-1 on gastric acid secretion
    J L Wallace
    Gastrointestinal Research Group, University of Calgary, Alberta, Canada
    Am J Physiol 261:G559-64. 1991
    ..Also, the effects of IL-1 beta on gastric acid secretion stimulated by bethanechol or histamine were assessed...
  10. ncbi Bedtime H2 blockers improve nocturnal gastric acid control in GERD patients on proton pump inhibitors
    S Xue
    The Graduate Hospital, Philadelphia, PA 19146, USA
    Aliment Pharmacol Ther 15:1351-6. 2001
    ..d. AC) effectively controls daytime gastric pH; however, nocturnal gastric acid breakthrough (NAB) occurs in more than 75% of patients...
  11. ncbi Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion
    Guanglin Cui
    Laboratory of Gastroenterology, Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, Tromsø N 9037, Norway
    World J Gastroenterol 13:493-6. 2007
    b>Gastric acid plays an important role in digesting food (especially protein), iron absorption, and destroying swallowed micro-organisms...
  12. ncbi Systematic review: Rebound acid hypersecretion after therapy with proton pump inhibitors
    N G M Hunfeld
    Central Hospital Pharmacy, The Hague, The Netherlands
    Aliment Pharmacol Ther 25:39-46. 2007
    ..The occurrence and the clinical relevance of rebound acid hypersecretion after discontinuation of proton pump inhibitors is unclear...
  13. ncbi Rabeprazole is superior to omeprazole for the inhibition of peptone meal-stimulated gastric acid secretion in Helicobacter pylori-negative subjects
    G V Ohning
    Research and Medical Services, Department of Veteran Affairs, VA GLAHS West Los Angeles Healthcare Center, and the Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 17:1109-14. 2003
    Peptone meal-stimulated gastric acid output is considered to be a reliable means to evaluate drug-mediated inhibition of stimulated gastric acid output, an important measure of the efficacy of the agents--such as proton pump inhibitors--..
  14. ncbi Histamine dependence of pentagastrin-stimulated gastric acid secretion in rats
    N P Shankley
    James Black Foundation, London, United Kingdom
    Yale J Biol Med 65:613-9. 1992
    Does gastrin stimulate gastric acid secretion by direct action on oxyntic cells, by releasing histamine, or by being potentiated by histamine? Previous studies in the mouse pointed to gastrin-regulated histamine release...
  15. ncbi Divalent cations regulate acidity within the lumen and tubulovesicle compartment of gastric parietal cells
    Andrea Gerbino
    Department of Surgery, Brigham and Women's Hospital, VA Boston Health Care System, Boston, MA 02115, USA
    Gastroenterology 126:182-95. 2004
    ..Conclusions: The effects of low-dose TPEN suggests that acidity within the TV/L compartment of the gastric gland may be regulated, at least in part, by its content of divalent cations such as Zn(2+), for which TPEN has high affinity...
  16. ncbi Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice
    Laura Piqueras
    Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain
    Br J Pharmacol 142:67-78. 2004
    1. Studies in rats suggest that PACAP modulates gastric acid secretion through the release of both histamine and somatostatin. 2...
  17. ncbi Effect of age and Helicobacter pylori infection on gastric acid secretion
    K Haruma
    First Department of Internal Medicine, Hiroshima University School of Medicine, Kasumi, Japan
    J Gastroenterol Hepatol 15:277-83. 2000
    Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori, the association of this bacterium with gastric acid secretion has also been discussed...
  18. ncbi Gastric acid secretion in aquaporin-4 knockout mice
    K S Wang
    Department of Surgery, Stanford University, CA 94305 5655, USA
    Am J Physiol Gastrointest Liver Physiol 279:G448-53. 2000
    The aquaporin-4 (AQP4) water channel has been proposed to play a role in gastric acid secretion...
  19. ncbi Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion
    Nils W G Lambrecht
    Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Physiol Genomics 21:81-91. 2005
    ..KCNQ1-KCNE2 appears to be the K efflux channel that is essential for gastric acid secretion.
  20. ncbi Esomeprazole therapy for gastric acid hypersecretion in children with cystinosis
    Ranjan Dohil
    UCSD Medical Center, San Diego, CA 92103 8450, USA
    Pediatr Nephrol 20:1786-93. 2005
    ..disease progression in children with cystinosis, but it may cause severe gastrointestinal (GI) symptoms through gastric acid-hypersecretion...
  21. ncbi PACAP stimulates gastric acid secretion in the rat by inducing histamine release
    A K Sandvik
    Department of Physiology and Biomedical Engineering, University Hospital of Trondheim, Faculty of Medicine, The Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Am J Physiol Gastrointest Liver Physiol 281:G997-G1003. 2001
    ..PACAP) stimulates enterochromaffin-like (ECL) cell histamine release, but its role in the regulation of gastric acid secretion is disputed...
  22. ncbi Increased gastric acid secretion after Helicobacter pylori eradication may be a factor for developing reflux oesophagitis
    T Koike
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Aliment Pharmacol Ther 15:813-20. 2001
    ..The role of acid secretion in reflux oesophagitis which may develop after H. pylori eradication is not well known...
  23. ncbi In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents
    Sonia Mesia-Vela
    Natural Products Section, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, 04044 020 Rua 03 de Maio 100, Sao Paulo, SP, Brazil
    J Ethnopharmacol 111:403-8. 2007
    ..the hydrolysis of ATP by H(+),K(+)-ATPase with an IC(50) of 500 microg/ml, indicating that the inhibition of gastric acid secretion of Scoparia dulcis is related to the inhibition of the proton pump...
  24. ncbi Heterogeneity of acid secretion induced by carbachol and histamine along the gastric gland axis and its relationship to [Ca2+]i
    Jose Francisco Perez-Zoghbi
    Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Am J Physiol Gastrointest Liver Physiol 295:G671-81. 2008
    ..2, both triggered by Ca(2+) release. Maintenance of acid secretion depends on Ca(2+) entry and perhaps membrane fusion...
  25. ncbi Insights into the future of gastric acid suppression
    Kenneth R DeVault
    Department of Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32233, USA
    Nat Rev Gastroenterol Hepatol 6:524-32. 2009
    ..Although these agents could potentially achieve complete gastric acid suppression, risks may be associated with this level of suppression, including enteric infections and ..
  26. ncbi Gastric acid inhibition for fat malabsorption or gastroesophageal reflux disease in cystic fibrosis: longitudinal effect on bacterial colonization and pulmonary function
    Hubert P J van der Doef
    Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Pediatr 155:629-33. 2009
    To investigate bacterial colonization and pulmonary function longitudinally in patients with cystic fibrosis (CF) receiving drugs for gastric acid (GA) inhibition for fat malabsorption or for gastroesophageal reflux disease (GERD).
  27. ncbi Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy
    Christina Reimer
    Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
    Gastroenterology 137:80-7, 87.e1. 2009
    ..Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI). If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications...
  28. ncbi Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication
    Katsunori Iijima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Gastroenterol 44:819-25. 2009
    The measurement of serum pepsinogens is clinically useful to represent gastric acid secretion. Since both serum pepsinogens and gastric acid secretion are considerably altered by H...
  29. ncbi Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint
    Helge L Waldum
    Department of Gastroenterology and Liver Diseases, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Scand J Gastroenterol 45:389-94. 2010
    ..The aim of this paper is to review current knowledge of the regulation of gastric acid secretion, including maximal acid secretion, and to improve understanding of the pathogenesis of acid-related ..
  30. ncbi Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways
    Chun Mei Zhao
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7006, Trondheim, Norway
    Endocrinology 149:498-505. 2008
    ..ECL) cell-parietal cell axis is known to play an important role in the regulation of gastric acid secretion...
  31. ncbi An open-label, parallel, multiple-dose study comparing the pharmacokinetics and gastric acid suppression of rabeprazole extended-release with esomeprazole 40 mg and rabeprazole delayed-release 20 mg in healthy volunteers
    G Morelli
    St Mary s Hospital, McGill University, Westmount, Montreal, QC, Canada
    Aliment Pharmacol Ther 33:845-54. 2011
    Novel rabeprazole extended-release (ER) formulations were developed to provide prolonged gastric acid suppression and potentially improved clinical outcomes in GERD patients.
  32. ncbi The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
    Gastroenterology 134:696-705. 2008
    ..We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD...
  33. ncbi L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
    Stephanie M Busque
    Dept. of Surgery, Yale University, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 289:G664-9. 2005
    ..These data support the conclusion that amino acids, in conjunction with a physiological Ca(o)(2+) concentration, can induce acid secretion independent of hormonal stimulation via allosteric activation of the stomach CaSR...
  34. ncbi Nitric oxide inhibits gastric acid secretion by increasing intraparietal cell levels of cGMP in isolated human gastric glands
    Anna Berg
    Div of Cell Biology, Dept of Biomedicine and Surgery, Linkoping University, Sweden
    Am J Physiol Gastrointest Liver Physiol 289:G1061-6. 2005
    ..Furthermore, the results show that NO-induced inhibition of gastric acid secretion is a cGMP-dependent mechanism in the parietal cell involving the activation of GC.
  35. ncbi The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands
    Matthias M Dufner
    Institute of Physiology, University of Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 289:G1084-90. 2005
    b>Gastric acid secretion is activated by two distinct pathways: a neuronal pathway via the vagus nerve and release of acetylcholine and an endocrine pathway involving gastrin and histamine...
  36. ncbi The effect of gastric Acid on the absorption of posaconazole
    Rupali Jain
    Clin Infect Dis 46:1627; author reply 1627-8. 2008
  37. ncbi Safety of potent gastric acid inhibition
    Carlos Martín de Argila
    Gastroenterology Department, Ramon y Cajal Hospital, Madrid, Spain
    Drugs 65:97-104. 2005
    The proton pump inhibitors are a very effective drug group for the control of gastric acid secretion, which makes them of great use in the medical practice setting, while at the same time they represent one of the treatment groups widely ..
  38. ncbi Comparison of morning and evening administration of rabeprazole for gastro-oesophageal reflux and nocturnal gastric acid breakthrough in patients with reflux disease: a double-blind, cross-over study
    N D Pehlivanov
    Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    Aliment Pharmacol Ther 18:883-90. 2003
    To assess the effect of timing of rebeprazole (RB) 20 mg/d administration on oesophageal acid exposure and nocturnal gastric acid breakthrough (NGAB) in patients with GERD.
  39. ncbi Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion
    M M Khattab
    Pharmacology Department, Faculty of Pharmacy, Cairo University, Egypt
    Pharmacol Res 43:463-7. 2001
    ..Therefore, this study creates a new pathway for the potential treatment of NSAID gastric ulceration through modulation of NO synthesis, regardless of the effect on gastric acidity...
  40. ncbi Gastric acid normosecretion is not essential in the pathogenesis of mild erosive gastroesophageal reflux disease in relation to Helicobacter pylori status
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan
    Dig Dis Sci 49:787-94. 2004
    In the pathogenesis of gastroesophageal reflux disease (GERD), gastric acid is considered to be one of the most important factors, but little is known about the degree of gastric acid secretion in GERD patients...
  41. ncbi Intragastric acid suppression and pharmacokinetics of twice-daily esomeprazole: a randomized, three-way crossover study
    P O Katz
    Division of Gastroenterology and Nutrition, Albert Einstein Medical Center, Philadelphia, PA 19141, USA
    Aliment Pharmacol Ther 20:399-406. 2004
    ..Patients with refractory gastro-oesophageal reflux disease, extra-oesophageal reflux symptoms, Barrett's oesophagus, or Zollinger-Ellison syndrome may require greater acid suppression than that obtained with once-daily esomeprazole...
  42. ncbi Review article: relief of symptoms in gastric acid-related diseases--correlation with acid suppression in rabeprazole treatment
    P Miner
    Oklahoma Foundation for Digestive Research, Oklahoma City, OK 73104, USA
    Aliment Pharmacol Ther 20:20-9. 2004
    Symptom relief is one of the key goals in the management of gastric acid-related disorders such as gastro-oesophageal reflux disease (GERD), including nonerosive reflux disease (NERD), and duodenal and gastric ulcer...
  43. ncbi Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease
    Wojciech C Blonski
    Division of Gastroenterology, University of Pennsylvania Health System, Philadelphia 19104, USA
    Eur J Gastroenterol Hepatol 17:441-4. 2005
    Many gastric acid hypersecretory states (basal acid output of greater than 15...
  44. ncbi Insulin-like growth factor I accelerates gastric ulcer healing by stimulating cell proliferation and by inhibiting gastric acid secretion
    S Coerper
    Dept of General Surgery, University of Tubingen, Germany
    Scand J Gastroenterol 36:921-7. 2001
    ..The aim of the study was to determine: 1) whether IGF-I applied locally would support gastric ulcer healing by increasing cell proliferation and 2) the effect of IGF-I on gastric acid secretion.
  45. ncbi The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion
    J P Geibel
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06511, USA
    J Biol Chem 276:39549-52. 2001
    ..Here, we identified a novel pathway modulating gastric acid secretion through the stomach calcium-sensing receptor (SCAR) located on the basolateral membrane of gastric ..
  46. ncbi Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study
    Philip Miner
    Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, 711 Stanton L. Young Boulevard, Suite 619, Oklahoma City, OK 73104, USA
    Am J Gastroenterol 98:2616-20. 2003
    OBJECTIVES: Proton pump inhibitors owe their clinical efficacy to their ability to suppress gastric acid production...
  47. ncbi Gastric acid suppression and treatment of severe exocrine pancreatic insufficiency
    E P Dimagno
    Department of Internal Medicine, Mayo Clinic, 200 First Street S.W, Rochester, MN 55905, USA
    Best Pract Res Clin Gastroenterol 15:477-86. 2001
    ..This amount of lipolytic activity taken with an agent that suppresses gastric acid secretion improves fat absorption in most patients and may even abolish steatorrhoea.
  48. ncbi Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo
    Jai Moo Shin
    Department of Physiology and Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Biochem Pharmacol 71:837-49. 2006
    ..Tenatoprazole binds at the catalytic subunit of the gastric acid pump with a stoichiometry of 2.6 nmol mg(-1) of the enzyme in vitro...
  49. ncbi Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells
    Jan C Becker
    Department of Medicine B, University of Muenster, 48149 Muenster, Germany
    Biochem Biophys Res Commun 345:1014-21. 2006
    ..Moreover, our findings provide additional perspectives for a possible but yet unexplored use of PPIs in vasoprotection...
  50. ncbi Soraprazan: setting new standards in inhibition of gastric acid secretion
    W A Simon
    Department of Biochemistry Gastroenterology, ALTANA Pharma AG, Byk Gulden Strasse 2, 78467 Konstanz, Germany
    J Pharmacol Exp Ther 321:866-74. 2007
    ..Rapid and consistent inhibition of acid secretion by soraprazan renders the P-CABs a promising group of compounds for therapy of GERD...
  51. ncbi Gastric acid secretion after blockade of angiotensin AT1 receptors in the Na(+)-depleted rat
    L Chow
    Research Department, Pharmaceuticals Division, Ciba Geigy Ltd, Basel, Switzerland
    Eur J Pharmacol 294:309-17. 1995
    ..that angiotensin II acting through the angiotensin AT1 receptor plays an important role in the control of gastric acid secretion...
  52. ncbi Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants
    L Ceglia
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Osteoporos Int 20:71-8. 2009
    In 17 adults on a fixed metabolic diet, an 11-day course of cinacalcet increased serum gastrin and basal gastric acid output, but not maximal gastric acid output, compared with a placebo...
  53. ncbi Helicobacter pylori infection and chronic gastric acid hyposecretion
    E M El-Omar
    University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Gastroenterology 113:15-24. 1997
    We have identified a subgroup of Helicobacter pylori-infected subjects with low or absent gastric acid output...
  54. ncbi Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach
    Takeshi Sugiura
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 25:2617-27. 2005
    b>Gastric acid contributes to dyspeptic symptoms, including abdominal pain, in patients with disorders of the proximal gastrointestinal tract...
  55. ncbi Meal-stimulated gastric acid secretion and integrated gastric acidity in gastro-oesophageal reflux disease
    J D Gardner
    Science for Organizations, Inc, Chatham, NJ 07928, USA
    Aliment Pharmacol Ther 17:945-53. 2003
    No current methods exist to determine meal-stimulated gastric acid secretion in humans under conditions that approximate those of daily living with the ingestion of breakfast, lunch and dinner.
  56. ncbi Effects of esomeprazole on acid output in patients with Zollinger-Ellison syndrome or idiopathic gastric acid hypersecretion
    David C Metz
    Division of Gastroenterology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 102:2648-54. 2007
    To evaluate the efficacy and safety of oral esomeprazole in the control of gastric acid hypersecretion in patients with hypersecretory states.
  57. ncbi Ultrastructural transformation of gastric parietal cells reverting from the active to the resting state of acid secretion revealed in isolated rat gastric mucosa model processed by high-pressure freezing
    Akira Sawaguchi
    Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
    J Electron Microsc (Tokyo) 55:97-105. 2006
    ..The present findings provide new insights into the functional transformation in gastric parietal cells reverting to their resting conformation...
  58. ncbi Association between antidepressant use and prescribing of gastric acid suppressants
    Janice Ma
    Canadian Forces Health Services, Ottawa, Ontario
    Can J Psychiatry 51:178-84. 2006
    ..To determine whether an increased risk of gastrointestinal events is present in younger, generally healthy adults who consume antidepressants...
  59. ncbi Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion
    Marion Danzer
    Deartment of Experimental and Clinical Pharmacology, University of Graz, A-8010 Graz, Austria
    Am J Physiol Gastrointest Liver Physiol 286:G403-11. 2004
    ..These communication modalities interact because, firstly, acid secretion enhances afferent signaling of gastric acid backdiffusion and, secondly, gastrin activates NTS neurons through stimulation of CCK(1) receptors on vagal ..
  60. ncbi Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system
    T Okumura
    Third Department of Internal Medicine, Asahikawa Medical College, Japan
    Endocrinology 141:2854-60. 2000
    ..Food consumption, gastric acid secretion, and gastric emptying were measured after injection of CART into the cerebrospinal fluid in 24-h ..
  61. ncbi Identification of ezrin as a target of gastrin in immature mouse gastric parietal cells
    Adelina Pagliocca
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 93:1174-89. 2008
    The gastric acid-secreting parietal cell exhibits profound morphological changes on stimulation...
  62. ncbi Association between gastric acid and mucin secretion in dyspeptic patients
    Y Niv
    Department of Gastroenterology, Beilinson Campus, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel
    Digestion 65:141-8. 2002
    ..The maintenance of an intact gastric mucosa implies a balance between aggressive, such as acid, and protective factors such as mucin. We examined gastric aspirates to determine a possible correlation between gastric acid and mucin contents.
  63. ncbi The basis for the decreased response to proton pump inhibitors in gastro-oesophageal reflux disease patients without erosive oesophagitis
    J D Gardner
    Science for Organizations, Inc, Chatham, NJ 07928, USA
    Aliment Pharmacol Ther 18:891-905. 2003
    ..The reason why heartburn in gastro-oesophageal reflux disease subjects without oesophagitis is less responsive to proton pump inhibitors than heartburn in those with erosive oesophagitis is not known...
  64. ncbi Helicobacter pylori eradication releases prolonged increased acid secretion following omeprazole treatment
    Derek Gillen
    GI Unit, Aberdeen Royal Infirmary, Scotland
    Gastroenterology 126:980-8. 2004
    ..pylori -infected subjects, but eradicating the infection releases the phenomenon. The accentuated H. pylori -related oxyntic gastritis induced by omeprazole is likely to protect against the rebound phenomenon...
  65. ncbi Effect of omeprazole on acid gastroesophageal reflux and gastric acidity in preterm infants with pathological acid reflux
    Taher I Omari
    Department of Paediatrics, University of Adelaide, Australia
    J Pediatr Gastroenterol Nutr 44:41-4. 2007
    ..The aim of this study was to determine the effect of 0.7 mg/kg/d omeprazole on gastric acidity and acid gastroesophageal reflux in preterm infants with reflux symptoms and pathological acid reflux on 24-h pH probe...
  66. ncbi Review article: pharmacology of esomeprazole and comparisons with omeprazole
    J Dent
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
    Aliment Pharmacol Ther 17:5-9. 2003
    ..superior delivery has been shown to cause a more consistent and greater suppression of pentagastrin-stimulated gastric acid secretion by esomeprazole, 20 mg, compared with omeprazole, 20 mg...
  67. ncbi [Non-erosive gastroesophageal reflux disease. Incidence of clinical forms, characteristics of esophageal exposure to acid and symptomatic correlations]
    Julio César Soto Pérez
    Laboratorio de Motilidad Gastrointestinal, Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, C P 14000, Mexico, D F
    Rev Gastroenterol Mex 68:113-9. 2003
    ..Studies in NERD patients using esophageal pH monitoring and symptom index (SI) have suggested different subgroups or clinical forms...
  68. ncbi Pharmacokinetics and pharmacodynamics of lansoprazole in children with gastroesophageal reflux disease
    David Gremse
    Division of Pediatric GI/Nutrition, University of South Alabama, Mobile, Alabama 36604-3273, USA
    J Pediatr Gastroenterol Nutr 35:S319-26. 2002
    ..Lansoprazole significantly increased the mean 24-hour intragastric pH and the percentages of time intragastric pH was above 3 and 4 when children were dosed with either 15 or 30 mg according to body weight...
  69. ncbi Review of esomeprazole in the treatment of acid disorders
    David A Johnson
    Eastern Virginia Medical School, Division of Gastroenterology, 885 Kempsville Road, Suite 114, Norfolk, VA 23505, USA
    Expert Opin Pharmacother 4:253-64. 2003
    ..exposure and less interindividual variability compared with omeprazole, and more effective suppression of gastric acid production compared with other proton pump inhibitors...
  70. ncbi Review article: gastric acidity--comparison of esomeprazole with other proton pump inhibitors
    J G Hatlebakk
    Department of Medicine, Haukeland Sykehus, University of Bergen, N 5021 Bergen, Norway
    Aliment Pharmacol Ther 17:10-5; discussion 16-7. 2003
    b>Gastric acid suppression is the most effective medical therapy to control acidic gastro-oesophageal reflux: individuals in whom therapy fails usually have inadequate acid suppression...
  71. ncbi The effect of intravenous pantoprazole and ranitidine for improving preoperative gastric fluid properties in adults undergoing elective surgery
    Dilek Memis
    Departments of Anaesthesiology and Biostatistics, Trakya University Medical Faculty, Edirne, Turkey
    Anesth Analg 97:1360-3. 2003
    ..We concluded that IV pantoprazole and ranitidine, given 1 h before surgery, are effective in reducing gastric pH and volume...
  72. ncbi Inhibitory potency of twice-a-day omeprazole on gastric acidity is enhanced by eradication of H. pylori in duodenal ulcer patients
    A B R Thomson
    Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Alberta, Canada
    Dig Dis Sci 48:2045-56. 2003
    ..pylori. Thus, in DU the pH-elevating potency of omeprazole taken twice a day is greater in the presence than in the absence of an H. pylori infection...
  73. ncbi Effect of GastroGard and three compounded oral omeprazole preparations on 24 h intragastric pH in gastrically cannulated mature horses
    A M Merritt
    Island Whirl Equine Colic Research Laboratory, College of Veterinary Medicine, University of Florida, Box 100136, Gainesville, Florida 32610-0136, USA
    Equine Vet J 35:691-5. 2003
    ..OBJECTIVES: To compare the gastric acid inhibitory efficacy of one manufactured ('GastroGard') and 3 generic pharmacy-compounded preparations of the ..
  74. ncbi The effects of nocturnal acid breakthrough on Helicobacter pylori eradication
    Jin Il Kim
    Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    Helicobacter 7:331-6. 2002
    BACKGROUND: The effects of nocturnal gastric acid breakthrough (NAB) on Helicobacter pylori eradication are still unknown in peptic ulcer patients...
  75. ncbi Determination of the reduction in gastric acidity necessary to prevent pathological oesophageal reflux in patients with gastro-oesophageal reflux disease treated with a proton pump inhibitor
    J D Gardner
    Science for Organizations, Inc, Chatham, NJ 07928, USA
    Aliment Pharmacol Ther 17:955-64. 2003
    ..In subjects with gastro-oesophageal reflux disease treated with a gastric antisecretory agent, the extent to which gastric acidity needs to be reduced to prevent pathological oesophageal acid exposure is not known...
  76. ncbi Acid exposure and altered acid clearance in GERD patients treated for Helicobacter pylori infection
    G Sarnelli
    Department of Clinical and Experimental Medicine, Division of Hepatogastroenterology, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    Dig Liver Dis 35:151-6. 2003
    ..CONCLUSION: In patients with gastroesophageal reflux disease, Helicobacter pylori eradication is associated with increased acid exposure of the proximal esophagus and delayed distal acid clearance...
  77. ncbi The acidity index: a simple approach to the measurement of gastric acidity
    R Tutuian
    Division of Gastroenterology, Medical University of South Carolina, Charleston, SC 29425, USA
    Aliment Pharmacol Ther 19:443-8. 2004
    ..This parameter is easy to calculate, but does not identify the actual pH level. Recent studies have recommended the use of the integrated intragastric acidity as a more refined method of assessing intragastric acid control...
  78. ncbi Nocturnal acid breakthrough: clinical significance and correlation with esophageal acid exposure
    Tina M Ours
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 98:545-50. 2003
    ..The aim of this study was to evaluate prospectively the degree of upright and supine esophageal and gastric acid suppression using various PPI regimens in comparison to the addition of an H2RA at bedtime...
  79. ncbi Proton pump inhibitors in children: a review
    F Marchetti
    Department of Pediatrics, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
    Dig Liver Dis 35:738-46. 2003
    ..They provide a high level of gastric acid inhibition with few adverse effects...
  80. ncbi CYP2C19 polymorphism and proton pump inhibitors
    Ulrich Klotz
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstr 112, D 70376 Stuttgart, Germany
    Basic Clin Pharmacol Toxicol 95:2-8. 2004
    ..Therefore initial genotyping for this enzyme and higher dosage in extensive metabolizers is likely to improve the clinical efficacy of proton pump inhibitors...
  81. ncbi Acid inhibition in GERD-how much is enough?
    Sami R Achem
    Am J Gastroenterol 99:997-9. 2004
    b>Gastric acid plays a fundamental role in the development of mucosal injury and symptoms in gastro-esophageal reflux disease(GERD)...
  82. ncbi Review article: is stringent control of gastric pH useful and practical in GERD?
    P J Kahrilas
    North Western University, Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA
    Aliment Pharmacol Ther 20:89-94; discussion 95-6. 2004
    ..agents in the treatment of gastro-oesophageal reflux disease is related to how consistently and completely gastric acid secretion is suppressed, intragastric pH monitoring is a useful tool in stratifying therapies...
  83. ncbi Review article: physiologic and clinical effects of proton pump inhibitors on non-acidic and acidic gastro-oesophageal reflux
    P B Miner
    Oklahoma Foundation for Digestive Disease, Oklahoma City, OK 73104, USA
    Aliment Pharmacol Ther 23:25-32. 2006
    The control of oesophageal acid exposure through gastric acid inhibition, as the basis for gastro-oesophageal reflux disease (GERD) treatment, arose from the apparent pH dependency of erosive oesophagitis and relationship to GERD symptoms...
  84. ncbi Review article: the role of acid suppression in patients with non-erosive reflux disease or functional heartburn
    K R Devault
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32233, USA
    Aliment Pharmacol Ther 23:33-9. 2006
    ....
  85. ncbi Acid-suppressive effects of generic omeprazole: comparison of three brands of generic omeprazole with original omeprazole
    T Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Dig Liver Dis 38:554-9. 2006
    ..Generic omeprazole contains the same active ingredient as original omeprazole and require verification of the bioequivalence with original omeprazole. However, very few clinical studies have been reported...
  86. ncbi Generic versus brand-name medicinal products: are they really interchangeable?
    D Motola
    Department of Pharmacology, University of Bologna, Via Irnerio 48, I 40126 Bologna BO, Italy
    Dig Liver Dis 38:560-2. 2006
  87. ncbi Laryngopharyngeal reflux disease with nocturnal gastric acid breakthrough while on proton pump inhibitor therapy
    Kiminori Sato
    Department of Otolaryngology, Head and Neck Surgery, Kurume University, School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Eur Arch Otorhinolaryngol 263:1121-6. 2006
    Laryngopharyngeal reflux disease (LPRD) with nocturnal recovery of gastric acid secretion (nocturnal acid breakthrough: NAB) with proton pump inhibitors (PPI) was first reported...
  88. ncbi Correlation between gastric pH and gastro-oesophageal reflux contents: ambulatory pH-impedance monitoring results
    S Roman
    Hospices Civils de Lyon, Exploration Fonctionnelle Digestive, and INSERM U45, Lyon, France
    Neurogastroenterol Motil 19:562-8. 2007
    ..We conclude that most acid and non-acid reflux episodes occur at acid gastric pH, as measured 10 cm below the LOS. This measure does not appear a good predictor of the pH of reflux events...
  89. ncbi Which has superior acid-suppressive effect, 10 mg omeprazole once daily or 20 mg famotidine twice daily? Effects of single or repeated administration in Japanese Helicobacter pylori-negative CYP2C19 extensive metabolizers
    Tomohiko Shimatani
    Department of General Medicine, Hiroshima University Hospital, 1 2 3 Kasumi, Hiroshima, Japan
    Dig Dis Sci 52:390-5. 2007
    ..This discrepancy possibly results from the "potentiation" of acid-suppressive effect of omeprazole and the "tolerance" phenomenon in respect to famotidine...
  90. ncbi Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC) o.m. famotidine 10 mg (Pepcid AC) b.d. and famotidine 20 mg b.d. over 14 days of treatment
    P B Miner
    Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Aliment Pharmacol Ther 25:103-9. 2007
    ..Thus, little direct comparison data exists between H2RAs and proton pump inhibitors for gastric acid suppression on day 1 of therapy...
  91. ncbi Effect of intravenous application of esomeprazole 40 mg versus pantoprazole 40 mg on 24-hour intragastric pH in healthy adults
    Dirk Hartmann
    Department of Medicine C Gastroenterology, Academic Teaching Hospital of the Johannes Gutenberg University of Mainz, Ludwigshafen, Germany
    Eur J Gastroenterol Hepatol 19:133-7. 2007
    ..It has been demonstrated that therapy with proton pump inhibitors reduces recurrence of bleeding following initial endoscopic treatment of bleeding peptic ulcers...
  92. ncbi Development of pancreatic acinar cell metaplasia after successful administration of omeprazole for 6 months in rats
    Tadashi Hagiwara
    Department of Pathology, Shiga University of Medical Science, Seta tsukinowa cho, Ohtsu, Shiga, 520 2192, Japan
    Dig Dis Sci 52:1219-24. 2007
    ..Long-term OPZ treatment causes hypergastrinemia and pancreatic acinar cell metaplasia in this animal model...
  93. ncbi The effect of omeprazole paste on intragastric pH in clinically ill neonatal foals
    L H Javsicas
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Equine Vet J 40:41-4. 2008
    ..Administration of omeprazole paste per os to healthy neonatal foals has been shown to effectively increase intragastric pH, but has not been evaluated in sick neonatal foals...
  94. ncbi Review article: intragastric and oesophageal pH monitoring in patients with gastro-oesophageal reflux disease
    P O Katz
    Division of Gastroenterology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA
    Aliment Pharmacol Ther 23:3-11. 2006
    ..This article reviews these and other uses of these tests in an effort to explore the question of how to optimally use oesophageal pH monitoring and gastric pH monitoring in patient management...
  95. ncbi Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial
    L Lundell
    Department of Surgery, Karolinska University Hospital, Huddinge, Sweden
    Aliment Pharmacol Ther 23:639-47. 2006
    ..The impact of long-term acid suppression on the gastric mucosa remains controversial...
  96. ncbi Review article: pH, healing and symptom relief with rabeprazole treatment in acid-related disorders
    M Robinson
    Oklahoma Foundation for Digestive Research, University of Oklahoma, Oklahoma City, OK 74104, USA
    Aliment Pharmacol Ther 20:30-7. 2004
    Control of gastric acid secretion by antisecretory agents has been the cornerstone of therapy in the successful management of all acid-related disorders, including gastro-oesophageal reflux disease (GERD), and duodenal and gastric ulcer...
  97. ncbi Frequency analyses of gastric pH in control and gastro-oesophageal reflux disease subjects treated with a proton-pump inhibitor
    J D Gardner
    Science for Organizations, Inc, Chatham, NJ 07928, USA
    Aliment Pharmacol Ther 20:1381-6. 2004
    ..We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess gastric acidity...
  98. ncbi Intravenous esomeprazole (40 mg and 20 mg) inhibits gastric acid secretion as effectively as oral esomeprazole: results of two randomized clinical studies
    Clive H Wilder-Smith
    GI Physiology Laboratory, Bern, Switzerland
    Eur J Gastroenterol Hepatol 17:191-7. 2005
    Two studies compared the effects of intravenous (i.v.) and oral esomeprazole (40 mg and 20 mg) on gastric acid suppression and pharmacokinetics after both single (day 1) and repeated (day 5) dosing.
  99. ncbi Intragastric acid control in non-steroidal anti-inflammatory drug users: comparison of esomeprazole, lansoprazole and pantoprazole
    J L Goldstein
    Department of Medicine, Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, IL 60612, USA
    Aliment Pharmacol Ther 23:1189-96. 2006
    ..Studies to date have not directly compared the pharmacodynamic efficacies of different proton pump inhibitors in controlling intragastric acidity in patients treated with non-steroidal anti-inflammatory drugs...
  100. ncbi Effects of rabeprazole or famotidine during cardiac surgery on perioperative gastric and esophageal pH readings
    Shigeyoshi Gon
    Department of Cardiovascular Surgery, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Jpn J Thorac Cardiovasc Surg 54:278-84. 2006
    ..b>Gastric acid secretion was less strongly suppressed in HP-negative patients in the FAM group, but was unaffected by HP ..
  101. ncbi Intragastric acidity during treatment with esomeprazole 40 mg twice daily or pantoprazole 40 mg twice daily--a randomized, two-way crossover study
    S Miehlke
    Medical Department I, Technical University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Aliment Pharmacol Ther 21:963-7. 2005
    ..Patients with severe or complicated reflux disease may require higher than standard doses of a proton pump inhibitor for sufficient acid suppression...

Research Grants78

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
    ..breath pH, the studies will focus on distinguishing between patients with primary airway acidification and gastric acid aspiration...
  2. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2010
    ..and mutant mouse models lacking NHE3, NHE2, or the gastric H+/K+-ATPase will permit us to evaluate the roles of gastric acid and the intestinal brush-border acidic microclimate in providing the H+ to drive DMT1-mediated Fe2+ transport...
  3. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2009
    ..and mutant mouse models lacking NHE3, NHE2, or the gastric H+/K+-ATPase will permit us to evaluate the roles of gastric acid and the intestinal brush-border acidic microclimate in providing the H+ to drive DMT1-mediated Fe2+ transport...
  4. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2009
    ..and mutant mouse models lacking NHE3, NHE2, or the gastric H+/K+-ATPase will permit us to evaluate the roles of gastric acid and the intestinal brush-border acidic microclimate in providing the H+ to drive DMT1-mediated Fe2+ transport...
  5. Toll-like Receptor Signaling in the Esophageal Epithelium
    Mei Lun Wang; Fiscal Year: 2010
    ..It is known that prolonged exposure to gastric acid leads to esophageal injury, resulting in cell necrosis in the stratum spinosum of the esophageal epithelium...
  6. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    John DeSimone; Fiscal Year: 2007
    ..Sour taste receptors detect a decrease in intracellular pH, but in the case of strong acids such as gastric acid (HCI) the mechanism by which protons enter taste cells remains unknown...
  7. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..Sour taste receptors detect a decrease in intracellular pH, but in the case of strong acids such as gastric acid (HCI) the mechanism by which protons enter taste cells remains unknown...
  8. SENSING PH AT THE GASTRIC SURFACE
    Marshall Montrose; Fiscal Year: 2003
    ..which molecules are transducers of the luminal pH stimulus that mediate the integrated regulation of both gastric acid and alkali secretion...
  9. SECRETIN & GASTRIC MOTILITY IN HEALTH & DUODENAL ULCERS
    Chung Owyang; Fiscal Year: 1993
    ..Recent studies have shown that abnormally rapid emptying of gastric acid may be an important factor in the pathogenesis of this disease process...
  10. CELL BIOLOGY OF ION PUMPS SORTING AND FUNCTION
    Michael Caplan; Fiscal Year: 2000
    ..presence of this molecule in a storage compartment appears to be responsible for the stimulated secretion of gastric acid following the fusion of these vesicles with apical cell membranes while the sensation of acid secretion is ..
  11. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    ..To colonize the intestinal tract, C. jejuni must successfully transit through the gastric acid barrier of the stomach to the more alkaline environment of the intestine...
  12. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2007
    ..However, PPIs do not cure GERD, a condition with no recognized abnormality of gastric acid secretion...
  13. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter Kahrilas; Fiscal Year: 2009
    ..However, PPIs do not cure GERD, a condition with no recognized abnormality of gastric acid secretion...
  14. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2010
    ..However, PPIs do not cure GERD, a condition with no recognized abnormality of gastric acid secretion...
  15. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2004
    ..important physiologic actions of GRP in the gastrointestinal tract, such as pancreatic enzyme secretion and gastric acid secretion, the hGRP-R also mediates signals of proliferation and differentiation in human intestinal and ..