colostrum

Summary

Summary: The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.

Top Publications

  1. ncbi Bovine colostrum as a biologic in clinical medicine: a review--Part II: clinical studies
    W G Struff
    Center for Transfusion Medicine Muenster, German Red Cross Blood Transfusion Service West gGmbH, Muenster, Germany
    Int J Clin Pharmacol Ther 46:211-25. 2008
  2. ncbi Immune components of bovine colostrum and milk
    K Stelwagen
    Dairy Science and Technology, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, 3240 New Zealand
    J Anim Sci 87:3-9. 2009
  3. ncbi Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs
    P G Halbur
    Iowa State University, Veterinary Medical Research Institute, Ames 50011, USA
    Vet Pathol 32:200-4. 1995
  4. pmc Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I)
    Fabian Deutskens
    Institute of Virology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Germany
    Vet Res 42:97. 2011
  5. ncbi Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trial
    Helen Byakwaga
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    J Infect Dis 204:1532-40. 2011
  6. ncbi GlycoSpectrumScan: fishing glycopeptides from MS spectra of protease digests of human colostrum sIgA
    Nandan Deshpande
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia
    J Proteome Res 9:1063-75. 2010
  7. ncbi Secretory IgA-Fcα receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics
    Eduardo Luzia França
    Post Graduate Program in Immunology and Parasitology of the Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças, MT, Brazil
    APMIS 119:710-9. 2011
  8. ncbi Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes
    Gerlândia N Pontes
    Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Pineal Res 41:136-41. 2006
  9. ncbi Associations between fatty acids in colostrum and breast milk and risk of allergic disease
    A J Lowe
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Clin Exp Allergy 38:1745-51. 2008
  10. ncbi Effects of bovine colostrum supplementation on immune variables in highly trained cyclists
    Cecilia M Shing
    School of Human Movement Studies, The University of Queensland, St Lucia, Queensland, Australia 4072
    J Appl Physiol (1985) 102:1113-22. 2007

Detail Information

Publications305 found, 100 shown here

  1. ncbi Bovine colostrum as a biologic in clinical medicine: a review--Part II: clinical studies
    W G Struff
    Center for Transfusion Medicine Muenster, German Red Cross Blood Transfusion Service West gGmbH, Muenster, Germany
    Int J Clin Pharmacol Ther 46:211-25. 2008
    The value of bovine colostrum as a biologic in medicine is documented in clinical trials and supported by relatively large databases containing case reports and anecdotal findings...
  2. ncbi Immune components of bovine colostrum and milk
    K Stelwagen
    Dairy Science and Technology, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, 3240 New Zealand
    J Anim Sci 87:3-9. 2009
    b>Colostrum and milk provide a complete diet for the neonate. In ruminants, colostrum is also the sole source of initial acquired immunity for the offspring. Milk therefore plays an important role in mammalian host defense...
  3. ncbi Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs
    P G Halbur
    Iowa State University, Veterinary Medical Research Institute, Ames 50011, USA
    Vet Pathol 32:200-4. 1995
    ..virus (PRRSV) antigens were detected by a streptavidin-biotin complex technique in tissues of 3-week-old colostrum-deprived pigs that had been inoculated intranasally with PRRSV and had developed moderate respiratory disease...
  4. pmc Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I)
    Fabian Deutskens
    Institute of Virology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, Germany
    Vet Res 42:97. 2011
    ..Alloantibodies reacting with blood leukocytes of calves were detected in serum and colostrum of dams, which have given birth to calves affected by BNP...
  5. ncbi Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trial
    Helen Byakwaga
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    J Infect Dis 204:1532-40. 2011
    ..This study aimed to determine the effect of intensification of cART with raltegravir or addition of hyperimmune bovine colostrum (HIBC) on CD4(+) T-cell count in such patients.
  6. ncbi GlycoSpectrumScan: fishing glycopeptides from MS spectra of protease digests of human colostrum sIgA
    Nandan Deshpande
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia
    J Proteome Res 9:1063-75. 2010
    ..GlycoSpectrumScan is freely available at www.glycospectrumscan.org ...
  7. ncbi Secretory IgA-Fcα receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics
    Eduardo Luzia França
    Post Graduate Program in Immunology and Parasitology of the Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças, MT, Brazil
    APMIS 119:710-9. 2011
    ..Accordingly, we studied the colostrum of hyperglycemic women to assess SIgA interactions with Fcα receptors of macrophages as well as the functional ..
  8. ncbi Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes
    Gerlândia N Pontes
    Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Pineal Res 41:136-41. 2006
    ..In this paper, we studied immune-pineal interactions in colostrum obtained from healthy puerperae and mothers with mastitis taking into account that, (a) melatonin levels in milk ..
  9. ncbi Associations between fatty acids in colostrum and breast milk and risk of allergic disease
    A J Lowe
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Clin Exp Allergy 38:1745-51. 2008
    ..However, there is controversy in this area, and we have previously observed that high levels of n-3 fatty acid (FA) in colostrum are associated with increased risk of allergic sensitization.
  10. ncbi Effects of bovine colostrum supplementation on immune variables in highly trained cyclists
    Cecilia M Shing
    School of Human Movement Studies, The University of Queensland, St Lucia, Queensland, Australia 4072
    J Appl Physiol (1985) 102:1113-22. 2007
    The aim of this study was to investigate the influence of low-dose bovine colostrum protein concentrate (CPC) supplementation on selected immune variables in cyclists...
  11. ncbi IgA antibodies, TGF-beta1 and -beta2, and soluble CD14 in the colostrum and development of atopy by age 4
    Erkki Savilahti
    Hospital for Children and Adolescents, University of Helsinki, Finland erkki savilahtihus fi
    Pediatr Res 58:1300-5. 2005
    ..We studied whether IgA, soluble CD14 (sCD14), or transforming growth factor (TGF)-beta in colostrum could affect the development of atopy in children up to age 4...
  12. ncbi [Reproducibility of bovine neonatal pancytopenia (BNP) via the application of colostrum]
    Paula Schröter
    Institut für Tierzucht und Vererbungsforschung, Stiftung Tierarztliche Hochschule Hannover
    Berl Munch Tierarztl Wochenschr 124:390-400. 2011
    ..The objectives of our investigation were to test if BNP could be reproduced using colostrum of cows with a BNP history and pre-colostral calves from farms where BNP has not been observed...
  13. ncbi Relative contribution of colostrum from Maedi-Visna virus (MVV) infected ewes to MVV-seroprevalence in lambs
    V Alvarez
    Instituto Vasco de Investigacion y Desarrollo Agrario NEIKER, Sanidad Animal, 48160 Derio, Vizcaya, Spain
    Res Vet Sci 78:237-43. 2005
    Maedi-visna virus (MVV) seroprevalence associated with consumption of colostrum from seropositive ewes was investigated in 276 housed lambs from birth to 300 days-old...
  14. pmc Perspectives on immunoglobulins in colostrum and milk
    Walter L Hurley
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nutrients 3:442-74. 2011
    Immunoglobulins form an important component of the immunological activity found in milk and colostrum. They are central to the immunological link that occurs when the mother transfers passive immunity to the offspring...
  15. ncbi Colostrum ingested during the first day of life by exclusively breastfed healthy newborn infants
    Walter Santoro
    Hospital das Clinicas de Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Pediatr 156:29-32. 2010
    To determine the mass of colostrum ingested by exclusively breastfed newborn infants during the first 24 hours of extrauterine life.
  16. ncbi Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis
    Massimiliano Cazzaniga
    Division of Chemoprevention, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 114:599-605. 2009
    ..multiplex PCR-based method the prevalence of alpha mucosal and beta cutaneous HPV DNA in 90 ductal lavages, colostrum and milk...
  17. ncbi A survey of bovine colostrum composition and colostrum management practices on Pennsylvania dairy farms
    S I Kehoe
    Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
    J Dairy Sci 90:4108-16. 2007
    b>Colostrum composition and management were surveyed via sample and data collection from 55 dairy farms in Pennsylvania...
  18. ncbi Fractionized milk composition during removal of colostrum and mature milk
    C E Ontsouka
    Institute of Animal Genetics, Nutrition and Housing, University of Berne, Bremgartenstr 109a, CH 3012 Berne, Switzerland
    J Dairy Sci 86:2005-11. 2003
    Experiments were designed to study compositional differences in colostrum and mature milk and during the course of milk removal...
  19. ncbi Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders
    C Prosser
    AgResearch Ruakura, 2001 Hamilton, New Zealand
    J Appl Physiol (1985) 96:650-4. 2004
    ..rats were assigned to one of three dietary groups [standard diet (Cont; n = 8), standard diet plus bovine colostrum powder (BColost 1.7 g/kg; n = 8), or goat milk powder (GMilk 1...
  20. pmc The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin
    Rafia Mir
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
    Biophys J 97:3178-86. 2009
    ..We believe this indicates that C-lobe of lactoferrin can be exploited for the prevention of NSAID-induced gastropathy...
  21. ncbi Bovine Neonatal Pancytopenia: is this alloimmune syndrome caused by vaccine-induced alloreactive antibodies?
    Max Bastian
    Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, D 63225 Langen, Germany
    Vaccine 29:5267-75. 2011
    ..Instead, the syndrome is induced after ingestion of colostrum, the first milk that supplies the calf with maternal antibodies...
  22. ncbi Effect of on-farm commercial batch pasteurization of colostrum on colostrum and serum immunoglobulin concentrations in dairy calves
    S M Godden
    Department of Clinical and Population Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Dairy Sci 86:1503-12. 2003
    ..batch pasteurization on immunoglobulin (IgG) concentrations and the fluid and feeding characteristics of colostrum and to compare serum IgG concentrations in calves fed fresh versus pasteurized colostrum...
  23. pmc Ingestion of colostrum from specific cows induces Bovine Neonatal Pancytopenia (BNP) in some calves
    Annette Friedrich
    Clinic for Ruminants LMU Munich, Oberschleissheim, Germany
    BMC Vet Res 7:10. 2011
    ..field observations have led to the hypothesis that the aetiological principle may be transmitted to calves via colostrum.The objective of the present study was to verify whether ingestion of colostrum from dams of known BNP calves ..
  24. ncbi Heat treatment of bovine colostrum. I: effects of temperature on viscosity and immunoglobulin G level
    S McMartin
    Department of Veterinary Population Medicine, University of Minnesota, St Paul 55108, USA
    J Dairy Sci 89:2110-8. 2006
    The objective of this study was to identify the critical temperature, at or below which heat-treatment of bovine colostrum would produce no significant changes in viscosity, IgG concentration, or Ig activity...
  25. ncbi Feeding heat-treated colostrum to neonatal dairy heifers: effects on growth characteristics and blood parameters
    J A Elizondo-Salazar
    Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
    J Dairy Sci 92:3265-73. 2009
    ..lymphocyte counts, health scores, growth, and starter intake after receiving unheated or heat-treated colostrum. First-milking colostrum was collected from Holstein cows and frozen at -20 degrees C to accumulate a large ..
  26. ncbi Evaluation of the effects of oral colostrum supplementation during the first fourteen days on the health and performance of preweaned calves
    A C B Berge
    College of Veterinary Medicine, Washington State University, Pullman 99164, USA
    J Dairy Sci 92:286-95. 2009
    ..The objective of this clinical trial was to determine the effect of colostrum supplementation of the milk replacer ration on morbidity, mortality, feed intake, and weight gain of preweaned ..
  27. ncbi Milk immunoglobulins and complement factors
    H Korhonen
    Agricultural Research Centre of Finland, Food Research, FIN 31600 Jokioinen, Finland
    Br J Nutr 84:S75-80. 2000
    The importance of colostrum for the growth and health of newborn offspring is well known...
  28. ncbi Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent
    A R Jensen
    Department of Animal Science and Animal Health, Division of Animal Nutrition, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg, Denmark
    J Nutr 131:3259-65. 2001
    Uptake of colostrum just after birth is essential to stimulate intestinal growth and function, and in many species, including pigs, colostrum also provides immunological protection via the absorption of immunoglobulin G (IgG)...
  29. ncbi Compartmentalization of small ruminant lentivirus between blood and colostrum in infected goats
    Giuliano Pisoni
    Department of Veterinary Pathology, Hygiene and Public Health, University of Milano, Via Celoria 10, 20133 Milano, Italy
    Virology 369:119-30. 2007
    ..SRLV) subtype A (Maedi-Visna virus) and B (caprine arthritis-encephalitis virus) variants was analyzed in colostrum and peripheral blood mononuclear cells of four naturally infected goats...
  30. ncbi Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model
    P G Halbur
    College of Veterinary Medicine, Iowa State University, Ames 50011, USA
    J Vet Diagn Invest 8:11-20. 1996
    One hundred forty-six 5-week- old cesarean-derived, colostrum-deprived (CDCD) pigs were inoculated intranasally with 1 of 9 US porcine reproductive and respiratory syndrome virus (PRRSV) isolates...
  31. ncbi Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Am J Clin Nutr 72:5-14. 2000
    b>Colostrum is the specific first diet of mammalian neonates and is rich in immunoglobulins, antimicrobial peptides, and growth factors...
  32. ncbi Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    Clin Sci (Lond) 100:627-33. 2001
    ..Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice...
  33. ncbi Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk
    T A Reinhardt
    Periparturient Diseases of Cattle Research Unit, USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA
    J Dairy Sci 91:2307-18. 2008
    ..iTRAQ), was used to quantify protein changes in milk fat globule membranes (MFGM) that were isolated from d 1 colostrum and compared with MFGM from d 7 milk...
  34. ncbi Nutritional plane and selenium supply during gestation affect yield and nutrient composition of colostrum and milk in primiparous ewes
    A M Meyer
    Center for Nutrition and Pregnancy, Department of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA
    J Anim Sci 89:1627-39. 2011
    ..to investigate effects of nutritional plane and Se supply during gestation on yield and nutrient composition of colostrum and milk in first parity ewes. Rambouillet ewe lambs (n = 84, age = 240 ± 17 d, BW = 52.1 ± 6...
  35. ncbi Detection of Torque teno sus virus types 1 and 2 by nested polymerase chain reaction in sera of sows at parturition and of their newborn piglets immediately after birth without suckling colostrum and at 24 hr after suckling colostrum
    Chenga Tshering
    United Graduate School of Veterinary Medicine, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Vet Med Sci 74:315-9. 2012
    ..6 sows (Sows 1-6) at parturition and in sera of their newborn piglets immediately after birth without suckling colostrum was performed by nested polymerase chain reaction (nPCR)...
  36. ncbi Prophylactic application of bovine colostrum ameliorates murine colitis via induction of immunoregulatory cells
    Peggy Bodammer
    Division of Gastroenterology, Centrum of Internal Medicine, University of Rostock, 18057 Rostock, Germany
    J Nutr 141:1056-61. 2011
    ..Herein, we addressed the question whether bovine colostrum, the first milk produced by mammals, is able to prevent dextran sulfate sodium (DSS)-induced colitis in mice...
  37. ncbi Effect of human milk and colostrum on Entamoeba histolytica
    Ciler Akisu
    Department of Parasitology, School of Medicine, Dokuz Eylul University, 35340 Inciralti Izmir, Turkey
    World J Gastroenterol 10:741-2. 2004
    Many defense factors of the mother's colostrum or milk protect infants from intestinal, respiratory and systemic infections. In the present study, we investigated the effect of colostrum and mature human milk on E...
  38. ncbi Evaluation of horizontal transmission of bovine viral diarrhea virus type 1a from experimentally infected white-tailed deer fawns (Odocoileus virginianus) to colostrum-deprived calves
    María E Negrón
    Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA
    Am J Vet Res 73:257-62. 2012
    To assess the transmission of bovine viral diarrhea virus (BVDV) from experimentally infected white-tailed deer fawns to colostrum-deprived calves by use of a BVDV strain isolated from hunter-harvested white-tailed deer.
  39. ncbi Effects of prolonged breastfeeding and colostrum fatty acids on allergic manifestations and infections in infancy
    E Morales
    Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
    Clin Exp Allergy 42:918-28. 2012
    ..In developed countries World Health Organization recommendation of 6 months' exclusive breastfeeding is under debate...
  40. ncbi The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes
    Tania Marchbank
    Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, UK
    Am J Physiol Gastrointest Liver Physiol 300:G477-84. 2011
    ..We examined bovine colostrum, a natural source of growth factors, as a potential moderator of such effects...
  41. ncbi [Interference of the blood glucose control in the transition between phases I and II of lactogenesis in patients with type 1 diabetes mellitus]
    Angela M de Morais Oliveira
    Banco de Leite Humano, Hospital das Clinicas, Universidade Federal de Uberlandia, MG, Brasil
    Arq Bras Endocrinol Metabol 52:473-81. 2008
    ..The transition between those phases is characterized by an increase of the lactose concentration in the colostrum. This study aimed to evaluate the interference of type 1 Diabetes mellitus in the transition between phases I ..
  42. ncbi In vitro and in vivo evaluation of the efficacy of bovine colostrum against human rotavirus infection
    Mizuho Inagaki
    United Graduate School of Agricultural Science, Gifu University, Yanagido, Gifu, Japan
    Biosci Biotechnol Biochem 74:680-2. 2010
    We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6-7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro...
  43. ncbi Kinetics of anti-Fasciola IgG antibodies in serum and milk from dairy cows during lactation, and in serum from calves after feeding colostrum from infected dams
    Mercedes Mezo
    Laboratorio de Parasitologia, Centro de Investigaciones Agrarias de Mabegondo Xunta de Galicia, Carretera AC 542 de Betanzos a Mesón do Vento, Galicia, Spain
    Vet Parasitol 168:36-44. 2010
    ..In newborn calves fed colostrum from infected dams, the levels of anti-Fasciola antibodies increased rapidly, then decreased sharply and were no ..
  44. ncbi Binding of Norovirus virus-like particles (VLPs) to human intestinal Caco-2 cells and the suppressive effect of pasteurized bovine colostrum on this VLP binding
    Kosuke Murakami
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan
    Biosci Biotechnol Biochem 74:541-7. 2010
    ..Then the suppressive effect of pasteurized bovine colostrum was analyzed on the VLP binding to Caco-2 cells by immunoblotting...
  45. ncbi A survey of dairy calf management practices in Canada that affect animal welfare
    E Vasseur
    Department of Animal Sciences, Laval University, Quebec, Canada
    J Dairy Sci 93:1307-15. 2010
    ..6% of farms relied on the dam to provide colostrum and none checked colostrum quality or passive transfer of immunity, 4) dehorning and removal of extra teats ..
  46. ncbi Changes in colostrum of Murrah buffaloes after calving
    A K Dang
    National Dairy Research Institute, Karnal, 132 001, Haryana, India
    Trop Anim Health Prod 41:1213-7. 2009
    b>Colostrum samples were collected from 8 Murrah buffaloes on days 1, 2, 3, 4 and 5 after calving. Levels of IgG averaged 54.0 mg/ml at calving, then decreased significantly (P < 0.01). IgA and IgM on day 1 were 3.22 mg/ml and 5...
  47. pmc Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells
    T Adar
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel
    Clin Exp Immunol 167:252-60. 2012
    ..Bovine colostrum has therapeutic effects in a variety of chronic infections. However its effectiveness in NASH was never studied...
  48. ncbi Colostrinin: a naturally occurring compound derived from mammalian colostrum with efficacy in treatment of neurodegenerative diseases, including Alzheimer's
    Michael G Stewart
    The Open University, Laboratory of Functional Neurocytology, Department of Life Sciences, Milton Keynes, MK7 6AA, UK
    Expert Opin Pharmacother 9:2553-9. 2008
    ..It might also be of considerable utility as a veterinary nutraceutical for companion animals...
  49. ncbi Bovine colostrum supplementation attenuates the decrease of salivary lysozyme and enhances the recovery of neutrophil function after prolonged exercise
    Glen Davison
    Department of Sport and Exercise Science, Aberystwyth University, Carwyn James Building, Penglais Campus, Aberystwyth, Ceredigion SY23 3FD, UK
    Br J Nutr 103:1425-32. 2010
    Oral supplementation with bovine colostrum (COL) has been shown to enhance immunity in human subjects...
  50. ncbi Secretory immunoglobulin A obtained from pooled human colostrum and milk for oral passive immunization
    Cristiane B Carbonare
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Pediatr Allergy Immunol 16:574-81. 2005
    ..The aim of the present study was to obtain a SIgA preparation from pooled human colostrum and milk, which should maintain the essential properties of the antibodies suitable for clinical oral ..
  51. ncbi Impact of maternal probiotic-supplemented dietary counseling during pregnancy on colostrum adiponectin concentration: a prospective, randomized, placebo-controlled study
    Raakel Luoto
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Early Hum Dev 88:339-44. 2012
    ..The breast milk bioactive substances such as adiponectin, have a presumably long-term impact upon the health and well-being of a child...
  52. ncbi Dynamic changes of immunoglobulin concentrations in pig colostrum and serum around parturition
    I Markowska-Daniel
    Department of Swine Diseases, National Veterinary Research Institute, al Partyzantow 57, 24 100 Puławy, Poland
    Pol J Vet Sci 13:21-7. 2010
    The aim of the study was the determination of IgA, IgM and IgG concentrations in porcine serum and colostrum, in order to evaluate their variations in the perinatal period, as well as to clarify whether there is a correlation between ..
  53. ncbi Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: an in vitro study on bacterial attachment, antibody levels and cytokine production
    Heather J L Brooks
    Department of Microbiology and Immunology, Otago School of Medical Sciences, New Zealand
    FEMS Immunol Med Microbiol 48:347-54. 2006
    ..The aim of this study was to determine whether spray-dried bovine colostrum demonstrated potential in vitro as a prophylactic for NEC...
  54. ncbi Effect of secretory immunoglobulin A on bacterial translocation in an enterocyte-lymphocyte co-culture model
    T Sawai
    Section of Pediatric Surgery, University of Michigan, Mott Children's Hospital, Ann Arbor, MI 48109-0245, USA
    Pediatr Surg Int 17:275-9. 2001
    ..5 +/- 1 log10CFU/ml). Inhibition of BT was negated when sIgA and mannose were removed by washing prior to E. Coli addition (3.6 +/- 0.5 log10CFU/ml), suggesting that both inhibitors act through bacterial binding...
  55. pmc Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation
    D Filipp
    Department of Immunology, University of Toronto, and The Arthritis and Immune Disorder Research Centre, The Toronto Hospital, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 98:603-8. 2001
    ..Consistent with biological activity of sCD14 in vitro, its administration to neonatal mice enhances Ig secretion. The results presented establish sCD14 as a naturally occurring soluble B cell mitogen of mammalian origin...
  56. ncbi Immune modulatory function of abundant immune-related microRNAs in microvesicles from bovine colostrum
    Qi Sun
    Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University School of Life Sciences, Nanjing, 210093, China
    Protein Cell 4:197-210. 2013
    b>Colostrum provides essential nutrients and immunologically active factors that are beneficial to newborns...
  57. pmc An overlap of breastfeeding during late pregnancy is associated with subsequent changes in colostrum composition and morbidity rates among Peruvian infants and their mothers
    Grace S Marquis
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 133:2585-91. 2003
    ..Further in-depth studies are warranted to determine the cumulative effects associated with a breast-feeding/pregnancy overlap on infant and maternal outcomes...
  58. ncbi Enterocin C, a class IIb bacteriocin produced by E. faecalis C901, a strain isolated from human colostrum
    Antonio Maldonado-Barragán
    Departamento de Nutricion, Bromatología y Tecnología de Alimentos, Universidad Complutense de Madrid, Spain
    Int J Food Microbiol 133:105-12. 2009
    ..bacteriocin was purified from culture supernatants of Enterococcus faecalis C901, a strain isolated from human colostrum. Enterocin C consists of two distinct peptides, named EntC1 and EntC2, whose complementary action is required ..
  59. ncbi Assessment of the bacterial diversity of human colostrum and screening of staphylococcal and enterococcal populations for potential virulence factors
    Esther Jiménez
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Universidad Complutense de Madrid, Avda Puerta de Hierro, S N, 28040 Madrid, Spain
    Res Microbiol 159:595-601. 2008
    In contrast to breast milk, little is known about the bacterial composition of human colostrum. The objective of this work was to analyze the bacterial diversity of colostrum obtained from healthy women and to characterize the dominant ..
  60. ncbi Nutritional, hormonal, and environmental effects on colostrum in sows
    C Farmer
    Agriculture and Agri Food Canada, Dairy and Swine R and D Centre, Sherbrooke, Quebec, Canada J1M 1Z3
    J Anim Sci 87:56-64. 2009
    It is widely recognized that an early and high intake of colostrum is a major determinant of piglet survival during the early suckling period...
  61. ncbi Bacteriological, biochemical, and immunological modifications in human colostrum after Holder pasteurisation
    I Espinosa-Martos
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Universidad Complutense de Madrid, Spain
    J Pediatr Gastroenterol Nutr 56:560-8. 2013
    The objective of this work was to evaluate the effect of Holder pasteurisation of human colostrum on a variety of microbiological, biochemical, and immunological parameters.
  62. ncbi Human colostrum T lymphocytes and their effector cytokines actively aid the development of the newborn immune system
    L Ciardelli
    Neonatal Immunology Research Laboratories, Neonatology and Neonatal Intensive Care Unit Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Int J Immunopathol Pharmacol 21:781-6. 2008
    b>Colostrum contains soluble and cellular components, the latter mainly T lymphocytes. We expanded in vitro colostrum T lymphocytes (CoTL) to evaluate phenotype and capability of cytokine production...
  63. ncbi Breastfeeding, long-chain polyunsaturated fatty acids in colostrum, and infant mental development
    Monica Guxens
    Center for Research in Environmental Epidemiology, Barcelona, Spain
    Pediatrics 128:e880-9. 2011
    ..Breastfeeding has been associated with improved neurodevelopment in children. However, it remains unknown to what extent nutritional advantages of breast milk may explain this relationship...
  64. ncbi Effect of Mannheimia (Pasteurella) haemolytica infection on acute-phase proteins and some mineral levels in colostrum-breast milk-fed or colostrum-breast milk-deprived sheep
    P A Ulutas
    Faculty of Veterinary Medicine, Department of Biochemistry, Adnan Menderes University, Isikli, Turkey
    Vet Res Commun 30:485-95. 2006
    ..A total of 26 Chios breed sheep were fed colostrum-breast milk (control, n = 15)or were deprived afterseparation from their mother immediately after birth(..
  65. ncbi Effects of gestational plane of nutrition and selenium supplementation on mammary development and colostrum quality in pregnant ewe lambs
    T J Swanson
    Center for Nutrition and Pregnancy, Department of Animal Sciences, North Dakota State University, Fargo 58105, USA
    J Anim Sci 86:2415-23. 2008
    To examine effects of nutritional plane and Se supplementation on colostrum quality and mammary development, individually fed, pregnant Rambouillet ewe lambs were allotted randomly to 1 of 6 treatments in a 2 x 3 factorial arrangement...
  66. ncbi Expressing and storing colostrum antenatally for use in the newborn period
    Suzanne G Cox
    Tasmanian Lactation Consultants, PO Box 1342, Lindisfarne TAS 7015, Australia
    Breastfeed Rev 14:11-6. 2006
    b>Colostrum is universally acknowledged as the perfect first food for infants. Oxytocin is the hormone of both labour and lactation but the literature shows that it does not always induce labour...
  67. ncbi Colostrinin proline-rich polypeptide complex from ovine colostrum--a long-term study of its efficacy in Alzheimer's disease
    Jerzy Leszek
    Department of Psychiatry, Medical University of Wrocław, Wrocław, Poland
    Med Sci Monit 8:PI93-6. 2002
    Colostrinin, a proline-rich polypeptide complex (PRP) isolated from ovine colostrum, with immunoregulatory and procognitive properties, has shown positive effects in the treatment of Alzheimer's disease (AD)...
  68. ncbi Morphological changes and virus distribution in the ileum of colostrum-deprived calves inoculated with non-cytopathic bovine viral diarrhoea virus genotype-1
    M Pedrera
    Department of Comparative Pathology, Veterinary Faculty, University of Cordoba, Edificio Sanidad Animal, Campus de Rabanales, Cordoba, Spain
    J Comp Pathol 141:52-62. 2009
    Eight colostrum-deprived calves were inoculated intranasally with a non-cytopathic strain of bovine viral diarrhoea virus (BVDV) genotype-1 and killed in batches of two at 3, 6, 9 and 14 days post-inoculation (dpi)...
  69. ncbi Obtaining hyperimmune anti-Cryptosporidium parvum ovine colostrum. A study of the humoral immune response in immunized sheep
    S Martín-Gomez
    Departamento de Patologia Animal Sanidad Animal, Facultad de Veterinaria, Universidad de Leon, C Profesor Pedro Cármenes s n, 24071 Leon, Spain
    Parasitol Res 98:119-29. 2006
    ..Serum was collected at first immunization and thereafter every 2 to 4 weeks. Colostrum and milk were collected as well. All samples were assayed for C...
  70. ncbi Fatty acid profile of colostrum and milk of ewes supplemented with fish meal and the subsequent plasma fatty acid status of their lambs
    M M Or-Rashid
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Anim Sci 88:2092-102. 2010
    ..during late gestation and early lactation would increase the proportion of docosahexaenoic acid (22:6n-3) in colostrum and milk and 2) examine the subsequent effect on the plasma fatty acid profile of nursing lambs...
  71. ncbi The effect of fermented liquid feeding on the faecal microbiology and colostrum quality of farrowing sows
    V Demecková
    Int J Food Microbiol 79:85-97. 2002
    ..on the lactic acid bacteria (LAB):Coliform (L:C) ratio in the faeces of farrowing sows and the quality of sow colostrum. Eighteen multiparous sows were randomly allocated to one of three dietary treatments for approximately 2 weeks ..
  72. pmc Prevention and treatment of influenza with hyperimmune bovine colostrum antibody
    Wy Ching Ng
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 5:e13622. 2010
    ..However, preparation of appropriate Ab in large scale, quickly and on a yearly basis is viewed as a significant logistical hurdle for this approach to control seasonal influenza...
  73. ncbi Diabetes induced immunological and biochemical changes in human colostrum
    G Morceli
    Post Graduate Program in Gynecology, Obstetrics and Mastology of Botucatu Medical School, Sao Paulo State University UNESP, Sao Paulo, Brazil
    Acta Paediatr 100:550-6. 2011
    This article describes the changes and relationships between biochemical and immunological parameters in the colostrum and serum of diabetic women.
  74. ncbi Colostrum supplementation restores insulin-like growth factor -1 levels and alters muscle morphology following massive small bowel resection
    Prue M Pereira-Fantini
    Intestinal Failure and Clinical Nutrition Group, Murdoch Childrens Research Institute, Atlantic Philanthropy Building, Flemington Road, Parkville 3052, Victoria, Australia
    JPEN J Parenter Enteral Nutr 32:266-75. 2008
    b>Colostrum protein concentrate (CPC) contains a high level of insulin-like growth factor-1 (IGF-1). IGF-1 and IGF binding protein (IGFBPs) may play an important role during the postresection adaptation response...
  75. ncbi Effect of colostrum immunoglobulin concentration on immunity in Majorera goat kids
    C Rodriguez
    Department of Animal Science, Las Palmas de Gran Canaria University, Arucas 35413, Spain
    J Dairy Sci 92:1696-701. 2009
    The aim of the research was to evaluate the effects of immunoglobulin G (IgG) colostrum concentration on goat kid immune status when the total amount of IgG fed was constant...
  76. ncbi Transfer of humoral and cell-mediated immunity via colostrum in pigs
    Katerina Nechvatalova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Vet Immunol Immunopathol 142:95-100. 2011
    The first aim of our study was to obtain information on the transmission of antigen-specific antibodies from colostrum to respiratory tract mucosa in piglets...
  77. ncbi Feeding colostrum, its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves
    U Blättler
    Division of Nutritional Pathology, Faculty of Veterinary Medicine, CH 3012 Berne, Switzerland
    J Nutr 131:1256-63. 2001
    We studied the effects of amounts of colostrum consumed on intestinal morphology and proliferation and digestive enzyme activities in neonatal calves...
  78. ncbi Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs
    Hanne K Møller
    Department of Systems Biology, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Br J Nutr 105:44-53. 2011
    ..We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve ..
  79. ncbi Nucleosides and nucleotides: natural bioactive substances in milk and colostrum
    E Schlimme
    Bundesanstalt für Milchforschung, Institut für Chemie und Physik, Kiel, Germany
    Br J Nutr 84:S59-68. 2000
    ..From the technochemical point of view, the ribonucleoside pattern is influenced by thermal treatment of milk. In addition ribonucleosides are useful indicators for quantifying adulterations of milk and milk products...
  80. pmc Changes in composition of colostrum of Egyptian buffaloes and Holstein cows
    Alaa M Abd El-Fattah
    Dairy Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt
    BMC Vet Res 8:19. 2012
    Changes in colostrum composition of Egyptian buffaloes and Holstein cows collected at calving, 6, 12, 24, 48, 72, 96, 120 h and after 14 days of parturition were studied...
  81. ncbi Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery
    Edwin Bölke
    Department of Surgery, University of Ulm, Germany
    Shock 17:9-12. 2002
    ..We conclude that prophylactic oral application of lactobin reduces perioperative endotoxemia and prevents reduction of ENC, suggesting a stabilization of gut barrier during abdominal surgery...
  82. pmc Antibody responses in serum, colostrum, and milk of swine after infection or vaccination with transmissible gastroenteritis virus
    E H Bohl
    Infect Immun 6:289-301. 1972
    ..with special reference to the titers and the immunoglobulin (Ig) class of TGE neutralizing antibodies in colostrum and milk...
  83. ncbi Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus
    S R Bolin
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:185-94. 2001
    Cesarean-derived, colostrum-deprived pigs (n = 23) were inoculated intranasally and subcutaneously with a low cell culture passage of type 2 porcine circovirus...
  84. ncbi Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestine
    Kareena L Schnabl
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Br J Nutr 101:694-700. 2009
    ..content and individual ganglioside composition of differentiated Caco-2 cells are similar to those of human colostrum and neonatal rat intestine...
  85. ncbi Induction of HIV-1 MPR(649-684)-specific IgA and IgG antibodies in caprine colostrum using a peptide-based vaccine
    Stephanie M Dorosko
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Vaccine 26:5416-22. 2008
    Induction of antigen-specific antibodies against HIV-1 in colostrum and milk may help prevent breast milk transmission of the virus...
  86. ncbi Isolation of bovine immunoglobulins resistant to peptic digestion: new perspectives in the prevention of failure in passive immunization of neonatal calves
    A C R C Porto
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    J Dairy Sci 90:955-62. 2007
    ..and disease susceptibility are greatly influenced by failure in passive immunization, normally provided by colostrum ingestion just after birth...
  87. ncbi Heat-treatment of bovine colostrum. II: effects of heating duration on pathogen viability and immunoglobulin G
    S Godden
    Department of Veterinary Population Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
    J Dairy Sci 89:3476-83. 2006
    Batches (30-L) of first-milking bovine colostrum, inoculated with Mycoplasma bovis (10(8) cfu/mL), Listeria monocytogenes (10(6) cfu/mL), Escherichia coli O157:H7 (10(6) cfu/mL), Salmonella enteritidis (10(6) cfu/mL), and Mycobacterium ..
  88. ncbi Effect of supplementing sows' feed with alpha-tocopherol acetate and vitamin C on transfer of alpha-tocopherol to piglet tissues, colostrum, and milk: aspects of immune status of piglets
    A Pinelli-Saavedra
    Centro de Investigacion en Alimentacion y Desarrollo, A C, Carretera a la Victoria, Km 0 6, P O Box 1735, Hermosillo, Sonora 83000, Mexico
    Res Vet Sci 85:92-100. 2008
    ..AT was determined in colostrum, milk, piglet plasma (cord blood) and tissues at birth and on day 21...
  89. ncbi Modulation by colostrum-acquired maternal antibodies of systemic and mucosal antibody responses to rotavirus in calves experimentally challenged with bovine rotavirus
    V Parreño
    Instituto de Virologia, CICV y A, INTA, Castelar, Bs As, Argentina
    Vet Immunol Immunopathol 100:7-24. 2004
    The effect of colostral maternal antibodies (Abs), acquired via colostrum, on passive protection and development of systemic and mucosal immune responses against rotavirus was evaluated in neonatal calves...
  90. ncbi Bovine neonatal immunology
    G M Barrington
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA
    Vet Clin North Am Food Anim Pract 17:463-76. 2001
    ..and dependent on passively acquired maternal immunoglobulins, immune cells, and other substances from colostrum for protection...
  91. ncbi Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a review
    Leyton W Gapper
    Fonterra Research Centre, Dairy Farm Road, Private Bag 11029, Palmerston North, New Zealand
    Anal Bioanal Chem 389:93-109. 2007
    ..The review also discusses nutraceutical applications, regulatory issues, stability of IgG and the significance of primary reference material in IgG analysis...
  92. ncbi Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment
    W G Struff
    Center for Transfusion Medicine, Munster, German Red Cross Blood Transfusion Service West gGmbH, Munster, Germany
    Int J Clin Pharmacol Ther 45:193-202. 2007
    ..In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-..
  93. ncbi Effect of heat and high-pressure treatments on microbiological quality and immunoglobulin G stability of caprine colostrum
    A J Trujillo
    Centre Especial de Recerca Planta de Tecnologia dels Aliments CERPTA, CeRTA, XiT, Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Dairy Sci 90:833-9. 2007
    ..nor Listeria monocytogenes were detected, whereas coagulase-positive staphylococci were found in various colostrum samples with an overall mean of 1.02 log cfu/mL...
  94. ncbi Hyperimmune bovine colostrum specific for recombinant Cryptosporidium parvum antigen confers partial protection against cryptosporidiosis in immunosuppressed adult mice
    M C Jenkins
    Immunology and Disease Resistance Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
    Vaccine 17:2453-60. 1999
    ..Serum was collected at each immunization and first colostrum was collected after parturition; all were assayed for Cryptosporidium-specific antibodies (Ab)...
  95. ncbi Feeding heat-treated colostrum or unheated colostrum with two different bacterial concentrations to neonatal dairy calves
    J A Elizondo-Salazar
    Department of Dairy and Animal Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Dairy Sci 92:4565-71. 2009
    The objective of this study was to determine the effects of feeding heat-treated colostrum or unheated colostrum of different bacterial counts on passive transfer of immunity in neonatal dairy calves...
  96. ncbi Effects of feeding heat-treated colostrum on passive transfer of immune and nutritional parameters in neonatal dairy calves
    J L Johnson
    Department of Veterinary Population Medicine, University of Minnesota, St Paul 55108, USA
    J Dairy Sci 90:5189-98. 2007
    The first objective of this study was to describe the effect of on-farm heat treatment of colostrum on colostral bacteria counts and IgG concentrations. The second objective was to describe the effect of feeding heat-treated (vs...
  97. ncbi Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum
    Ran Zhang
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    Anim Biotechnol 20:242-6. 2009
    ..of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 ..
  98. ncbi Milk supplemented with immune colostrum: protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirus
    V Parreño
    Instituto de Virologia, CICV y A INTA, CC 25, 1712 Castelar, Bs As, Argentina
    Vet Immunol Immunopathol 136:12-27. 2010
    ..All calves received control colostrum (CC; VN=65,536; IgG(1)=16,384) prior to gut closure followed by the milk supplemented with immune colostrum (VN=..
  99. ncbi Hyperimmune bovine colostrum in the treatment of shigellosis in children: a double-blind, randomized, controlled trial
    H Ashraf
    ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
    Acta Paediatr 90:1373-8. 2001
    ..Hyperimmune bovine colostrum (HBC) is a potentially innovative immunological option in the management of shigellosis together with ..
  100. ncbi Effect of heat treatment of bovine colostrum on bacterial counts, viscosity, and Immunoglobulin G concentration
    J A Elizondo-Salazar
    Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
    J Dairy Sci 93:961-7. 2010
    A study was conducted to identify the optimal temperature and time at which heat treatment of bovine colostrum would least change viscosity and IgG concentrations yet reduce bacterial count...
  101. ncbi Specific IgG activity against diarrheagenic bacteria in bovine immune milk and effect of pH on its antigen-binding activity upon heating
    Wei Gao
    College of Life Sciences, Nanjing Normal University, Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, and Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210046, P R China
    J Dairy Res 77:220-4. 2010
    Bovine colostrum and milk antibodies of calving and lactating cows immunized with a multivalent vaccine consisting of whole cells of three different species of pathogenic bacteria including four strains of enterotoxigenic Escherischia ..

Research Grants62

  1. Phase II Clinical Trial of Lactoferrin in Asthma
    Atul Varadhachary; Fiscal Year: 2005
    ..is a multifunctional immunomodulatory protein found in serum and exocrine secretions such as milk and colostrum where it acts as a component of the primary host defense system...
  2. Lactogenic immunity/probiotics: Effect on neonatal gut immunity
    Linda J Saif; Fiscal Year: 2010
    ..Our innovative studies will first assess the impact of colostrum (col)/milk and key maternal immunomediators (TGF2, IL4) on colonization by probiotics...
  3. Humanization of hFcRn Mice for Physiological Evaluation of Therapeutic Antibodies
    MICHAEL VAN WILES; Fiscal Year: 2013
    ..FcRn functions across many tissues and is critical for neonatal acquisition of maternal IgG via colostrum and milk, the pulmonary secretion of IgG and bidirectional transport of both IgG and immune complexes across the ..
  4. Oral anti-TNF antibody for inflammatory bowel disease
    Daniel E Tracey; Fiscal Year: 2013
    ..Avaxia is developing AVX-470h, an oral polyclonal anti-TNF antibody therapeutic for IBD from the early milk (colostrum) of immunized cows...
  5. Oral anti-TNF antibody for inflammatory bowel disease
    Barbara S Fox; Fiscal Year: 2010
    ..Avaxia is developing an oral polyclonal anti-TNF antibody therapeutic for IBD from the early milk (colostrum) of immunized cows...
  6. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Allan Walker; Fiscal Year: 2013
    ..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..
  7. Antibody protection against SIV transmission
    Sallie R Permar; Fiscal Year: 2013
    ..Our previous work isolating HIV Envelope-specific monoclonal antibodies from colostrum B cells of HIV-infected women has identified novel HIV Env-specific neutralizing mucosal antibodies produced in ..
  8. TREAT-VCU
    Arun J Sanyal; Fiscal Year: 2013
    ..aim 2 proposes a phase 2a "proof of concept" placebo- controlled, dose-ranging study of Imm 124-E (bovine colostrum enriched with IgG anti-lipopolysaccharide (LPS)) in subjects with severe AH...
  9. Transmission-blocking potential of novel HIV Env-specific mucosal antibodies
    Sallie R Permar; Fiscal Year: 2013
    ..isolation of HIV-1 Env-specific B cells and recombinant production of their monoclonal antibodies (mAbs) from colostrum of HIV-infected, lactating women...
  10. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 1991
    ..Using established techniques, we will determine if colostrum and its lymphoid cells modify the response to ingested antigen in the neonate by examining if systemic priming ..
  11. RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN SHEEP
    Arlene Stecenko; Fiscal Year: 1991
    ..First, the effect of age at the time of inoculation will be assessed. Three age groups will be studied: i) colostrum-fed 1 week old lambs, ii) lambs whose level of maternally-acquired antibody to RSV has reached a minimum, and ..
  12. T CELL REGULATION OF CARIES IMMUNITY/PERIODONTAL DISEASE
    Hiroshi Kiyono; Fiscal Year: 1992
    ..antigen-specific secretory IgA (S-IgA) responses in mucosal associated secretions including saliva, tears, colostrum and mucus secretions of the gastrointestinal and upper respiratory tracts, and that antigen-specific IgA ..
  13. BETA-CAROTENE IN HUMAN MILK: QUANTITATION AND TRANSPORT
    Louise Canfield; Fiscal Year: 1993
    ..our objective in Phase I is to identify the major carotenoids and retinoids in pooled samples of mature milk and colostrum. Diurnal variation of beta-carotene and retinal will be determined in mature milk samples...
  14. CONTROL OF CRYPTOSPORIDIOSIS BY NEUTRALIZING ANTIBODIES
    LANCE PERRYMAN; Fiscal Year: 1992
    ..41. 2: Produce colostrum that neutralizes Cryptosporidium parvum sporozoites and merozoites...
  15. NOVEL METHOD FOR INTESTINAL ABSORPTION OF ANTIBODIES
    Keith Mostov; Fiscal Year: 1999
    ..IgG is transported across the placenta to the fetus. After birth lgA in the milk and colostrum protects the GI tract, but these antibodies are not specifically absorbed into the infants circulation...
  16. MODULATION OF IN VITRO CRYPTOSPORIDIUM PARVUM INFECTION
    Timothy Flanigan; Fiscal Year: 1993
    ..We propose to evaluate whether and how different immunologic agents such as hyperimmune cow colostrum, polyclonal and monoclonal antisporozoite antibodies inhibit cryptosporidial infection of the human HT29...
  17. PROCESSING OF NUTRITIONAL ASPECTS OF BREAST MILK
    KHEM SHAHANI; Fiscal Year: 1980
    ..Also, arrangements are being made to collect colostrum and transitional milk samples so that the nutritional aspects of colostrum, transitional, and mature human milks ..
  18. Colostrum From Mothers Treated With Cyclosporine
    KRISTINA THIAGARAJAN; Fiscal Year: 2004
    ..The immediate goal is to describe and compare the quantity of immune factors and prolactin present in colostrum from those mothers' treated with immunosuppresive agents and those mother's who are not...
  19. STRAIN SPECIFICITY OF ANTI-CRYPTOSPORIDIUM IGG
    JOSEPH CRABB; Fiscal Year: 1992
    ..Hyperimmune anti-Cryptosporidium bovine colostrum, has shown a great deal of promise in limited human studies, providing therapeutic benefit to 7 of 8 ..
  20. IDENTIFYING CRYPTOSPORIDIUM PROTECTIVE ANTIGEN GENES
    JOSEPH CRABB; Fiscal Year: 1992
    ..No therapeutic drugs are available; however, bovine colostrum that contains anti-Cryptosporidium antibodies has proven efficacious in animal studies and patients...
  21. SECRETORY IGA SYSTEM--MOLECULAR-CELLULAR INTERACTIONS
    Jiri Mestecky; Fiscal Year: 1990
    ..Thus, we shall study the regulatory role of T cells isolated from human colostrum, the quintessential product of the secretory IgA system...
  22. IMMUNOTHERAPY FOR CRYPTOSPORIDIUM INFECTIONS
    JOSEPH CRABB; Fiscal Year: 1990
    ..Two independent groups have produced hyperimmune bovine anti-C. parvum colostrum which has been successful in the treatment of at least five cases of human cryptosporidiosis...
  23. Topical Anti-TNF Antibody for Oral Mucositis
    Barbara Fox; Fiscal Year: 2009
    ..In this proposal, Avaxia is isolating anti- TNF antibody from the early milk (colostrum) of immunized cows...
  24. Mother's Soothing: Metabolic and Physiologic Advantages
    Lawrence Gray; Fiscal Year: 2009
    ..e., sucrose, formula milk, and colostrum-during and not during crying;2) Are vulnerable infants (i.e...
  25. MATERNAL-FETAL TRANSFER OF ANTI-HEL ANTIBODY
    Margaret Keller; Fiscal Year: 1990
    ..Our preliminary studies suggest that transplacental and postnatal transfer via colostrum and milk of an IdXE positive anti-HEL monoclonal antibody from A/J mothers to their offspring results in ..
  26. PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATION
    Margaret Neville; Fiscal Year: 2002
    ....
  27. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  28. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  29. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 2004
    ..4) In utero, the fetal intestine is unresponsive to GLP-2. These hypotheses will be tested using a TPN-fed, colostrum-deprived, neonatal pig model with these aims: Aim 1: Quantify the physiological dose response of GLP-2 on ..
  30. Development Expression of Chemokines and Their Receptors
    DARLENE CALHOUN; Fiscal Year: 2002
    ..We further propose that defining circulating concentrations of chemokines critical for neutrophil migration would be essential to understanding their role in both health and disease. ..
  31. DEVELOPMENTAL EXPRESSION OF G-CSF IN THE PLACENTA
    DARLENE CALHOUN; Fiscal Year: 2002
    ....
  32. Role of Sialidase in Pulmonary Host Defenses and Acute Lung Injury
    Alan Cross; Fiscal Year: 2010
    ..Since inhibitors of sialidase are commercially available, these studies will provide the experimental rationale for testing a new therapeutic approach to the treatment of lung injury. ..
  33. LENTIVIRAL VARIATION AND AIDS
    Julie Overbaugh; Fiscal Year: 2008
    ..Collectively these studies will define the interplay between the properties of the infecting virus, the immune response and replication fitness in SIV/HIV pathogenesis. ..
  34. Evaluation of Anti-endotoxin Vaccine for Human Use
    Alan Cross; Fiscal Year: 2006
    ..If successful, these studies will lead to phase II and Ill studies for the prevention and treatment of sepsis. ..
  35. Early events during infection with anthrax
    Alan Cross; Fiscal Year: 2006
    ..abstract_text> ..
  36. SIALIC ACID MODULATION REGULATES NEUTROPHIL DIAPEDESIS
    Alan Cross; Fiscal Year: 2002
    ..These studies will define a new mechanism for a rapidly adaptable, temporally- restricted local response to inflammation. This proposal will provide new targets and additional approaches to the treatment of inflammation. ..
  37. OXIDATIVE STRESS, APOPTOSIS AND DRUG RESISTANCE
    Istvan Boldogh; Fiscal Year: 2003
    ..abstract_text> ..
  38. PREVENTION OF HIV SHEDDING IN WOMEN--TRIAL OF VITAMIN A
    Julie Overbaugh; Fiscal Year: 2003
    ..If this preliminary result is confirmed in a full-scale clinical trial, vitamin A supplementation may offer a simple inexpensive intervention to decrease heterosexual and vertical transmission of HIV-1 in the developing world. ..
  39. TRANSPORT GENE EXPRESSION AND DRUG ACCUMULATION IN MILK
    Patrick McNamara; Fiscal Year: 2004
    ..The identification of the mammary epithelial carrier proteins, their genes, and factors that control their regulation are the ultimate, long-term goals of this research program. ..
  40. Etiologic studies on EMND: An animal model for ALS
    Hussni Mohammed; Fiscal Year: 2004
    ..Data obtained from these pilot studies will represent a major breakthrough towards the understanding of the mechanism of the motor neuron disease and lay the foundation for more thorough investigation. ..
  41. A Plant-Derived, Multi-Component Tuberculosis Vaccine
    AMANDA WALMSLEY; Fiscal Year: 2004
    ..abstract_text> ..
  42. REGULATION OF FELV REPLICATION AND PATHOGENESIS
    Julie Overbaugh; Fiscal Year: 2004
    ..In this regard, it is striking that in both FeLV and HIV infection, there is selection for T-cell tropic, cytopathic variants in the host, despite the many differences between these viruses. ..
  43. Nipah Virus Marker Vaccine and Companion Diagnostic Test
    James Roth; Fiscal Year: 2005
    ..abstract_text> ..
  44. IgA inducing peptide
    D Estes; Fiscal Year: 2005
    ..In addition, the proposed studies will begin to examine determine the potential relationship between IGIP and clinical abnormality in IgA production. ..
  45. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2005
    ..abstract_text> ..
  46. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006
    ....