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| colostrumSummarySummary: The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates. Top Publications
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Publications
Heat treatment of bovine colostrum. I: effects of temperature on viscosity and immunoglobulin G levelS McMartin
Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108, USA
J Dairy Sci 89:2110-8. 2006The objective of this study was to identify the critical temperature, at or below which heat-treatment of bovine colostrum would produce no significant changes in viscosity, IgG concentration, or Ig activity...
Evaluation of the effects of oral colostrum supplementation during the first fourteen days on the health and performance of preweaned calvesA C B Berge
College of Veterinary Medicine, Washington State University, Pullman 99164, USA
J Dairy Sci 92:286-95. 2009..The objective of this clinical trial was to determine the effect of colostrum supplementation of the milk replacer ration on morbidity, mortality, feed intake, and weight gain of preweaned ..
Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disordersR J Playford
Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Am J Clin Nutr 72:5-14. 2000b>Colostrum is the specific first diet of mammalian neonates and is rich in immunoglobulins, antimicrobial peptides, and growth factors...
Immune components of bovine colostrum and milkK Stelwagen
Dairy Science and Technology, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, 3240 New Zealand
J Anim Sci 87:3-9. 2009b>Colostrum and milk provide a complete diet for the neonate. In ruminants, colostrum is also the sole source of initial acquired immunity for the offspring. Milk therefore plays an important role in mammalian host defense...
Feeding heat-treated colostrum to neonatal dairy heifers: effects on growth characteristics and blood parametersJ A Elizondo-Salazar
Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
J Dairy Sci 92:3265-73. 2009..lymphocyte counts, health scores, growth, and starter intake after receiving unheated or heat-treated colostrum. First-milking colostrum was collected from Holstein cows and frozen at -20 degrees C to accumulate a large ..
Bovine colostrum as a biologic in clinical medicine: a review--Part II: clinical studiesW G Struff
Center for Transfusion Medicine Muenster, German Red Cross Blood Transfusion Service West gGmbH, Muenster, Germany
Int J Clin Pharmacol Ther 46:211-25. 2008The value of bovine colostrum as a biologic in medicine is documented in clinical trials and supported by relatively large databases containing case reports and anecdotal findings...
Effect of on-farm commercial batch pasteurization of colostrum on colostrum and serum immunoglobulin concentrations in dairy calvesS M Godden
Department of Clinical and Population Sciences, University of Minnesota, St Paul, MN 55108, USA
J Dairy Sci 86:1503-12. 2003..batch pasteurization on immunoglobulin (IgG) concentrations and the fluid and feeding characteristics of colostrum and to compare serum IgG concentrations in calves fed fresh versus pasteurized colostrum...
Ingestion of colostrum from specific cows induces Bovine Neonatal Pancytopenia (BNP) in some calvesAnnette Friedrich
Clinic for Ruminants LMU Munich, Oberschleissheim, Germany
BMC Vet Res 7:10. 2011..field observations have led to the hypothesis that the aetiological principle may be transmitted to calves via colostrum.The objective of the present study was to verify whether ingestion of colostrum from dams of known BNP calves ..
Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig modelP G Halbur
College of Veterinary Medicine, Iowa State University, Ames 50011, USA
J Vet Diagn Invest 8:11-20. 1996One hundred forty-six 5-week- old cesarean-derived, colostrum-deprived (CDCD) pigs were inoculated intranasally with 1 of 9 US porcine reproductive and respiratory syndrome virus (PRRSV) isolates...
Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeabilityR J Playford
Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, UK
Clin Sci (Lond) 100:627-33. 2001..Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice...
Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiationD Filipp
Department of Immunology, University of Toronto, and The Arthritis and Immune Disorder Research Centre, The Toronto Hospital, Toronto, ON, Canada M5G 2M9
Proc Natl Acad Sci U S A 98:603-8. 2001..Consistent with biological activity of sCD14 in vitro, its administration to neonatal mice enhances Ig secretion. The results presented establish sCD14 as a naturally occurring soluble B cell mitogen of mammalian origin...
Milk immunoglobulins and complement factorsH Korhonen
Agricultural Research Centre of Finland, Food Research, FIN 31600 Jokioinen, Finland
Br J Nutr 84:S75-80. 2000The importance of colostrum for the growth and health of newborn offspring is well known...
Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milkT A Reinhardt
Periparturient Diseases of Cattle Research Unit, USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA
J Dairy Sci 91:2307-18. 2008..iTRAQ), was used to quantify protein changes in milk fat globule membranes (MFGM) that were isolated from d 1 colostrum and compared with MFGM from d 7 milk...
Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgeryEdwin Bölke
Department of Surgery, University of Ulm, Germany
Shock 17:9-12. 2002..We conclude that prophylactic oral application of lactobin reduces perioperative endotoxemia and prevents reduction of ENC, suggesting a stabilization of gut barrier during abdominal surgery...
Antibody responses in serum, colostrum, and milk of swine after infection or vaccination with transmissible gastroenteritis virusE H Bohl
Infect Immun 6:289-301. 1972..with special reference to the titers and the immunoglobulin (Ig) class of TGE neutralizing antibodies in colostrum and milk...
Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatmentW G Struff
Center for Transfusion Medicine, Munster, German Red Cross Blood Transfusion Service West gGmbH, Munster, Germany
Int J Clin Pharmacol Ther 45:193-202. 2007..In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-..
Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirusS R Bolin
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
J Vet Diagn Invest 13:185-94. 2001Cesarean-derived, colostrum-deprived pigs (n = 23) were inoculated intranasally and subcutaneously with a low cell culture passage of type 2 porcine circovirus...
Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a reviewLeyton W Gapper
Fonterra Research Centre, Dairy Farm Road, Private Bag 11029, Palmerston North, New Zealand
Anal Bioanal Chem 389:93-109. 2007..The review also discusses nutraceutical applications, regulatory issues, stability of IgG and the significance of primary reference material in IgG analysis...
Isolation of bovine immunoglobulins resistant to peptic digestion: new perspectives in the prevention of failure in passive immunization of neonatal calvesA C R C Porto
Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
J Dairy Sci 90:955-62. 2007..and disease susceptibility are greatly influenced by failure in passive immunization, normally provided by colostrum ingestion just after birth...
Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesisMassimiliano Cazzaniga
Division of Chemoprevention, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Breast Cancer Res Treat 114:599-605. 2009..multiplex PCR-based method the prevalence of alpha mucosal and beta cutaneous HPV DNA in 90 ductal lavages, colostrum and milk...
Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestineKareena L Schnabl
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Br J Nutr 101:694-700. 2009..content and individual ganglioside composition of differentiated Caco-2 cells are similar to those of human colostrum and neonatal rat intestine...
Effect of supplementing sows' feed with alpha-tocopherol acetate and vitamin C on transfer of alpha-tocopherol to piglet tissues, colostrum, and milk: aspects of immune status of pigletsA Pinelli-Saavedra
Centro de Investigacion en Alimentacion y Desarrollo, A C, Carretera a la Victoria, Km 0 6, P O Box 1735, Hermosillo, Sonora 83000, Mexico
Res Vet Sci 85:92-100. 2008..AT was determined in colostrum, milk, piglet plasma (cord blood) and tissues at birth and on day 21...
Hyperimmune bovine colostrum in the treatment of shigellosis in children: a double-blind, randomized, controlled trialH Ashraf
ICDDR, B Centre for Health and Population Research, Dhaka, Bangladesh
Acta Paediatr 90:1373-8. 2001..Hyperimmune bovine colostrum (HBC) is a potentially innovative immunological option in the management of shigellosis together with ..
Effects of feeding heat-treated colostrum on passive transfer of immune and nutritional parameters in neonatal dairy calvesJ L Johnson
Department of Veterinary Population Medicine, University of Minnesota, St Paul 55108, USA
J Dairy Sci 90:5189-98. 2007The first objective of this study was to describe the effect of on-farm heat treatment of colostrum on colostral bacteria counts and IgG concentrations. The second objective was to describe the effect of feeding heat-treated (vs...
GlycoSpectrumScan: fishing glycopeptides from MS spectra of protease digests of human colostrum sIgANandan Deshpande
Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia
J Proteome Res 9:1063-75. 2010..GlycoSpectrumScan is freely available at www.glycospectrumscan.org ...
Bovine neonatal immunologyG M Barrington
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA
Vet Clin North Am Food Anim Pract 17:463-76. 2001..and dependent on passively acquired maternal immunoglobulins, immune cells, and other substances from colostrum for protection...
Induction of HIV-1 MPR(649-684)-specific IgA and IgG antibodies in caprine colostrum using a peptide-based vaccineStephanie M Dorosko
Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Vaccine 26:5416-22. 2008Induction of antigen-specific antibodies against HIV-1 in colostrum and milk may help prevent breast milk transmission of the virus...
Effects of bovine immune and non-immune whey preparations on the composition and pH response of human dental plaqueV Loimaranta
Institute of Dentistry and Turku Immunology Centre, University of Turku, Finland
Eur J Oral Sci 107:244-50. 1999..Thus, the short term rinsing indicates favourable effects of bovine immune whey on human dental plaque...
Hyperimmune bovine colostrum specific for recombinant Cryptosporidium parvum antigen confers partial protection against cryptosporidiosis in immunosuppressed adult miceM C Jenkins
Immunology and Disease Resistance Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
Vaccine 17:2453-60. 1999..Serum was collected at each immunization and first colostrum was collected after parturition; all were assayed for Cryptosporidium-specific antibodies (Ab)...
Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine ColostrumRan Zhang
State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
Anim Biotechnol 20:242-6. 2009..of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 ..
Modulation by colostrum-acquired maternal antibodies of systemic and mucosal antibody responses to rotavirus in calves experimentally challenged with bovine rotavirusV Parreño
Instituto de Virologia, CICV y A, INTA, Castelar, Bs As, Argentina
Vet Immunol Immunopathol 100:7-24. 2004The effect of colostral maternal antibodies (Abs), acquired via colostrum, on passive protection and development of systemic and mucosal immune responses against rotavirus was evaluated in neonatal calves...
Milk supplemented with immune colostrum: protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirusV Parreño
Instituto de Virologia, CICV y A INTA, CC 25, 1712 Castelar, Bs As, Argentina
Vet Immunol Immunopathol 136:12-27. 2010..All calves received control colostrum (CC; VN=65,536; IgG(1)=16,384) prior to gut closure followed by the milk supplemented with immune colostrum (VN=..
Effect of heat treatment of bovine colostrum on bacterial counts, viscosity, and Immunoglobulin G concentrationJ A Elizondo-Salazar
Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
J Dairy Sci 93:961-7. 2010A study was conducted to identify the optimal temperature and time at which heat treatment of bovine colostrum would least change viscosity and IgG concentrations yet reduce bacterial count...
Specific IgG activity against diarrheagenic bacteria in bovine immune milk and effect of pH on its antigen-binding activity upon heatingWei Gao
College of Life Sciences, Nanjing Normal University, Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, and Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210046, P R China
J Dairy Res 77:220-4. 2010Bovine colostrum and milk antibodies of calving and lactating cows immunized with a multivalent vaccine consisting of whole cells of three different species of pathogenic bacteria including four strains of enterotoxigenic Escherischia ..
Effect of parity on lymphocytes in peripheral blood and colostrum of healthy Holstein dairy cowsHiromichi Ohtsuka
Kitasato University, Towada, Aomori, Japan
Can J Vet Res 74:130-5. 2010..investigated the leukocyte population and cytokine mRNA levels in peripheral blood mononuclear cells (PBMCs) and colostrum mononuclear cells (CCs) obtained from healthy cows soon after calving...
Colostrogenesis: mass transfer of immunoglobulin G1 into colostrumC R Baumrucker
Department of Dairy and Animal Science, The Pennsylvania State University, University Park, PA, USA
J Dairy Sci 93:3031-8. 2010..Mammary IgG(1) appearance in cow colostrum has typically been reported as a concentration and shows IgG(1) concentration to be extremely variable because ..
A survey of bovine colostrum composition and colostrum management practices on Pennsylvania dairy farmsS I Kehoe
Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
J Dairy Sci 90:4108-16. 2007b>Colostrum composition and management were surveyed via sample and data collection from 55 dairy farms in Pennsylvania...
Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigsP G Halbur
Iowa State University, Veterinary Medical Research Institute, Ames 50011, USA
Vet Pathol 32:200-4. 1995..virus (PRRSV) antigens were detected by a streptavidin-biotin complex technique in tissues of 3-week-old colostrum-deprived pigs that had been inoculated intranasally with PRRSV and had developed moderate respiratory disease...
Feeding heat-treated colostrum or unheated colostrum with two different bacterial concentrations to neonatal dairy calvesJ A Elizondo-Salazar
Department of Dairy and Animal Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Dairy Sci 92:4565-71. 2009The objective of this study was to determine the effects of feeding heat-treated colostrum or unheated colostrum of different bacterial counts on passive transfer of immunity in neonatal dairy calves...
Relative contribution of colostrum from Maedi-Visna virus (MVV) infected ewes to MVV-seroprevalence in lambsV Alvarez
, Sanidad Animal, 48160-Derio, Vizcaya, Spain
Res Vet Sci 78:237-43. 2005Maedi-visna virus (MVV) seroprevalence associated with consumption of colostrum from seropositive ewes was investigated in 276 housed lambs from birth to 300 days-old...
Heat-treatment of bovine colostrum. II: effects of heating duration on pathogen viability and immunoglobulin GS Godden
Department of Veterinary Population Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
J Dairy Sci 89:3476-83. 2006Batches (30-L) of first-milking bovine colostrum, inoculated with Mycoplasma bovis (10(8) cfu/mL), Listeria monocytogenes (10(6) cfu/mL), Escherichia coli O157:H7 (10(6) cfu/mL), Salmonella enteritidis (10(6) cfu/mL), and Mycobacterium ..
Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trialHelen Byakwaga
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
J Infect Dis 204:1532-40. 2011..This study aimed to determine the effect of intensification of cART with raltegravir or addition of hyperimmune bovine colostrum (HIBC) on CD4(+) T-cell count in such patients.
Effect of heat and high-pressure treatments on microbiological quality and immunoglobulin G stability of caprine colostrumA J Trujillo
Centre Especial de Recerca Planta de Tecnologia dels Aliments CERPTA, CeRTA, XiT, Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
J Dairy Sci 90:833-9. 2007..nor Listeria monocytogenes were detected, whereas coagulase-positive staphylococci were found in various colostrum samples with an overall mean of 1.02 log cfu/mL...
A full belly and colostrum: two major determinants of filial loveDavid Val-Laillet
Laboratoire de Comportement Animal, UMR 6175 CNRS INRA, université de Tours Haras nationaux, 37380 Nouzilly, France
Dev Psychobiol 45:163-73. 2004..Previous work has shown that colostrum ingestion facilitates the development of a preference for the mother...
Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniaeHedwig E Deubzer
Imperial College, Faculty of Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom
J Infect Dis 190:1758-61. 2004Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during ..
Cytokine profiling in human colostrum and milk by protein arrayMiloslav Kverka
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Clin Chem 53:955-62. 2007Human colostrum and milk contain components that influence development. Our aim was to use a protein array to determine the cytokine profile of human lacteal secretions and changes that occur during the early postpartum period.
Colostral proteins from cows immunised with Streptococcus mutans/S. sobrinus support the phagocytosis and killing of mutans streptococci by human leucocytesV Loimaranta
Institute of Dentistry, University of Turku, Finland
J Med Microbiol 48:917-26. 1999..Bovine colostrum inhibits the phagocytic activity of bovine leucocytes and this may reflect the biological activity of ..
From birth to colostrum: early steps leading to lamb survivalRaymond Nowak
Laboratoire de Comportements, Neurobiologie et Adaptation, UMR 6175 CNRS INRA Université François Rabelais Haras Nationaux, Unite de Physiologie de la Reproduction et des Comportements, INRA, 37380 Nouzilly, France
Reprod Nutr Dev 46:431-46. 2006New-born lambs have limited energy reserves and need a rapid access to colostrum to maintain homeothermy and survive. In addition to energy, colostrum provides immunoglobulins which ensure passive systemic immunity...
Use of immunoglobulin enriched bovine colostrum against oral challenge with enterohaemorrhagic Escherichia coli O157:H7 in miceKenji Funatogawa
Southern Direct Meat Products Inspection Office, Tochigi, Tochigi 328-0033, Japan
Microbiol Immunol 46:761-6. 2002An immunoglobulin enriched bovine colostrum preparation, IMMULAC (New Zealand Dairy Group, Cambridge, New Zealand), contains antibodies against various bacterial antigens...
Short communication: Absorption of protein and immunoglobulin g in calves fed a colostrum replacerG W Smith
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
J Dairy Sci 90:2905-8. 2007A well-managed colostrum program on farms is the most important step in reducing disease in neonatal calves...
Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled studyDanielle A W Wolvers
Unilever Food and Health Research Institute, Olivier van Noortlaan 120, NL 3133 AT, Vlaardingen, The Netherlands
Nutr J 5:28. 2006..effects on immune function are micronutrients such as vitamin C, vitamin E, beta-carotene and zinc, and colostrum. This study was designed to investigate the effects these ingredients on immune function markers in healthy ..
Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactationSadaki Asakuma
Graduate School of Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan
Biosci Biotechnol Biochem 71:1447-51. 2007Sialyl oligosaccharides of human milk/colostrum are generally believed to be of biological significance, for example with respect to anti-adhesion of pathogenic organism, providing precursors for biosynthesis of brain, and so on...
PCR detection of colostrum-associated Maedi-Visna virus (MVV) infection and relationship with ELISA-antibody status in lambsV Alvarez
, Sanidad Animal, 48160-Derio, Vizcaya, Spain
Res Vet Sci 80:226-34. 2006A recent large-scale experimental study showed that bottle-feeding ovine colostrum from seropositive ewes results in high MVV-seroconversion in lambs...
In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defenceA C van Hooijdonk
DMV International, R and D Center, PO Box 13, 5460 BA Veghel, The Netherlands
Br J Nutr 84:S127-34. 2000The in vivo evidence of the antimicrobial and antiviral activity of bovine milk and colostrum derived components are reviewed with special emphasis on lactoferrin and lactoperoxidase...
Survival of rotavirus antibody activity derived from bovine colostrum after passage through the human gastrointestinal tractJ Pacyna
Northfield Laboratories Pty Ltd, Oakden, South Australia, Australia
J Pediatr Gastroenterol Nutr 32:162-7. 2001..Several studies have shown that hyperimmune bovine colostrum, derived from cows immunized with rotavirus, can prevent rotavirus diarrhea when given passively...
Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometryD Barile
Department of Food Science and Technology, University of California, Davis 95616, USA
J Dairy Sci 93:3940-9. 2010..In the present work we measured, comprehensively and systematically, free milk OS in the colostrum of 7 Holstein-Friesian cows during the first 3 d of lactation in 12-h intervals by HPLC-chip/time-of-flight mass ..
An evaluation of Brix refractometry instruments for measurement of colostrum quality in dairy cattleV Bielmann
Department of Population Medicine, University of Guelph, Guelph, Ontario, Canada
J Dairy Sci 93:3713-21. 2010Acquisition of high quality colostrum is an important factor influencing neonatal calf health. Many methods have been used to assess the Ig concentration of colostrum; however, improved, validated evaluation tools are needed...
Does a calf's motivation to ingest colostrum depend on time since birth, calf vigor, or provision of heat?E Vasseur
Animal Sciences Department, Laval University, Quebec, Quebec, Canada
J Dairy Sci 92:3915-21. 2009Dairy producers often complain that calves have difficulty consuming the recommended amount of colostrum. A better understanding of factors affecting calves' motivation to ingest colostrum could help develop better management...
Improving passive transfer of immunoglobulins in calves. II: interaction between feeding method and volume of colostrum fedS M Godden
Department of Veterinary Population Medicine, University of Minnesota, St Paul, MN 55108, USA
J Dairy Sci 92:1758-64. 2009..esophageal tube feeder) on passive transfer of immunoglobulin (Ig) G when either a large or small volume of colostrum was fed...
Effect of colostrum administration by use of oroesophageal intubation on serum IgG concentrations in Holstein bull calvesMunashe Chigerwe
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
Am J Vet Res 69:1158-63. 2008To determine the amount of colostral IgG required for adequate passive transfer in calves administered colostrum by use of oroesophageal intubation and evaluate the impact of other factors on passive transfer of colostral immunoglobulins ..
Improving passive transfer of immunoglobulins in calves. I: dose effect of feeding a commercial colostrum replacerS M Godden
Department of Veterinary Population Medicine, University of Minnesota, St Paul, MN 55108, USA
J Dairy Sci 92:1750-7. 2009The objective of this study was to describe the effects of feeding 1 or 2 doses of a commercially available colostrum-derived colostrum replacer (CR) on passive transfer of immunoglobulins (Ig) in newborn dairy calves, including IgG, ..
Secretory anti-human immunodeficiency virus (HIV) antibodies in colostrum and breast milk are not a major determinant of the protection of early postnatal transmission of HIVP Becquart
Institut National de la Santé et de la Recherche Médicale U430, Hopital Broussais, Paris, France
J Infect Dis 181:532-9. 2000..These results suggest that humoral mucosal immunity to HIV does not appear as a predominant factor for protection against viral transmission through breast milk...
Microbial adhesion of Cryptosporidium parvum: identification of a colostrum-derived inhibitory lipidJoann Schmidt
Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana, IL 61802, USA
Mol Biochem Parasitol 162:32-9. 2008..especially dietary sources, of the inhibitory lipid and discovered it was principally derived from bovine colostrum. Interestingly, fresh colostrum yielded little or no inhibitory lipid, however, the lipid was found in ..
Localization of Mycobacterium avium subspecies paratuberculosis in artificially inoculated milk and colostrum by fractionationL Van Brandt
Institute for Agricultural and Fisheries Research ILVO, Technology and Food Science Unit, Brusselsesteenweg 370, 9090, Melle, Belgium
J Dairy Sci 93:4722-9. 2010..paratuberculosis (MAP) across the main milk and colostrum fractions (cream, curd, and whey)...
Health-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketonesJun Ho Kim
Department of Food and Biotechnology, Korea University, Jochiwon, Chungnam 339 700, South Korea
J Nutr Biochem 20:298-303. 2009Bovine colostrum (BC) has been reported to enhance immune function, reduce fat accumulation and facilitate the movement of glucose to the muscle...
Detection of colostrum-derived alloantibodies in calves with bovine neonatal pancytopeniaPhilip Simon Bridger
Institute for Hygiene and Infectious Diseases of Animals, Justus Liebig University, Frankfurter Strasse 85 89, 35392 Giessen, Germany
Vet Immunol Immunopathol 141:1-10. 2011..In this study we investigated whether this phenomenon is related to colostrum-derived alloantibodies directed against neonatal leukocytes...
Size distribution of fat globules in human colostrum, breast milk, and infant formulaM C Michalski
INRA UMR 1253, Science et Technologie du Lait et de l Oeuf Agrocampus 65, rue de Saint Brieuc, 35042 Rennes Cedex, France
J Dairy Sci 88:1927-40. 2005..We measured the MFG size distribution in colostrum and transitional human milk in comparison with fat globules of mature milk and infant formula...
Identification of minor proteins of human colostrum and mature milk by two-dimensional electrophoresisK Murakami
JCR Biopharmaceuticals Inc, San Diego, CA 92121, USA
Electrophoresis 19:2521-7. 1998..No major differences in the protein patterns were observed between the minor proteins of colostrum and mature milk, indicating that the minor proteins remained relatively constant during lactation...
Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrumY Habata
Discovery Research Laboratories 1, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, Japan
Biochim Biophys Acta 1452:25-35. 1999..Moreover, a large amount of apelin (14-93 pmol/ml) was found to be secreted in the bovine colostrum, and it was still detectable even in commercial bovine milk...
Detection of cytokines in bovine colostrumK Hagiwara
Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
Vet Immunol Immunopathol 76:183-90. 2000b>Colostrum contains factors that are protective for the neonate and may be a source of immunomodulary molecules that positively influence the immune status of the neonate...
Persistency of high proinflammatory cytokine levels from colostrum to mature milk in preeclampsiaAyse Binnur Erbagci
Department of Biochemistry, Faculty of Medicine, School of Medicine, University of Gaziantep, TR 27310, Gaziantep, Turkey
Clin Biochem 38:712-6. 2005..Recent evidence suggests a role of an excessive maternal inflammatory response in the pathogenesis of preeclampsia. Whether this imbalance can be transferred from mother to breast milk remains to be established...
Fractionized milk composition during removal of colostrum and mature milkC E Ontsouka
Institute of Animal Genetics, Nutrition and Housing, University of Berne, Bremgartenstr. 109a, CH-3012 Berne, Switzerland
J Dairy Sci 86:2005-11. 2003Experiments were designed to study compositional differences in colostrum and mature milk and during the course of milk removal...
Immunoglobulin concentrations in feline colostrum and milk, and the requirement of colostrum for passive transfer of immunity to neonatal kittensMelissa A Claus
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 2015 SW 16th Avenue, University of Florida, Gainesville, FL 32610, USA
J Feline Med Surg 8:184-91. 2006..have a colostral and milk phase of lactation differentiated by concentrations of immunoglobulins, and whether colostrum ingestion by newborn kittens is essential for optimal transfer of passive immunity...
Immune components (IgA, IgM, IgG, immune cells) of colostrum of Bangladeshi mothersS K Nazrul Islam
Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh
Pediatr Int 48:543-8. 2006b>Colostrum is the first defense for neonates. It is rich in immune components including immunoglobulins and viable immune cells...
Measurement of bisphenol A concentrations in human colostrumRyoko Kuruto-Niwa
School of Food and Nutritional Sciences, Laboratory of Microbiology and Host Defenses, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Chemosphere 66:1160-4. 2007..In the present study, we measured the concentrations of BPA in human colostrum by a competitive enzyme-linked immunosorbent assay (ELISA) with the aim of understanding the present status of ..
Bovine colostrum inhibits nuclear factor kappaB-mediated proinflammatory cytokine expression in intestinal epithelial cellsMin Ji An
Department of Internal Medicine and Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
Nutr Res 29:275-80. 2009b>Colostrum, a nutrient-rich fluid produced by female mammals immediately after giving birth, is loaded with several immune, growth, and tissue repair factors...
The influence of bovine colostrum supplementation on exercise performance in highly trained cyclistsC M Shing
School of Human Movement Studies, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
Br J Sports Med 40:797-801. 2006The aim of this experiment was to investigate the influence of low dose bovine colostrum supplementation on exercise performance in cyclists over a 10 week period that included 5 days of high intensity training (HIT).
Neutrophil function and plasma opsonic capacity in colostrum-fed and colostrum-deprived neonatal kittensRita M Hanel
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
Am J Vet Res 64:538-43. 2003..PROCEDURE: Kittens were randomized at birth into the following treatment groups: colostrum-fed, colostrum-deprived, or colostrum-deprived supplemented with feline or equine IgG...
Human colostrum: identification of minor proteins in the aqueous phase by proteomicsDavid J Palmer
LactoPharma, School of Biological Sciences, University of Auckland, Auckland, New Zealand
Proteomics 6:2208-16. 2006Human colostrum is an important source of protective, nutritional and developmental factors for the newborn...
Elevated extrahepatic expression and secretion of mammary-associated serum amyloid A 3 (M-SAA3) into colostrumT L McDonald
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Vet Immunol Immunopathol 83:203-11. 2001Mammary-associated serum amyloid A 3 (M-SAA3) was secreted at highly elevated levels in bovine, equine and ovine colostrum and found at lower levels in milk 4 days postparturition...
Variation of major neutral oligosaccharides levels in human colostrumS Asakuma
Graduate School of Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Eur J Clin Nutr 62:488-94. 2008Human colostrum is known to be important for the protection of infants against infection by pathogenic microorganisms...
Experimental reproduction of postweaning multisystemic wasting syndrome in cesarean-derived, colostrum-deprived piglets inoculated with porcine circovirus type 2 (PCV2): investigation of quantitative PCV2 distribution and antibody responsesY Okuda
Zen-noh Institute of Animal Health, 7 Ohja-mach, Sakura, Chiba 285-0043, Japan
J Vet Diagn Invest 15:107-14. 2003Sixteen cesarean-derived, colostrum-deprived piglets were inoculated intranasally with porcine circovirus type 2 (PCV2), originally isolated from a pig affected with postweaning multisystemic wasting syndrome (PMWS)...
Targeted antibodies in dairy-based productsLennart Hammarstrom
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, SE 141 86, Stockholm, Sweden
Adv Exp Med Biol 606:321-43. 2008Bovine colostrum contains immunoglobulins that provide the newborn calf with protection against microbial infections until its own immune system matures...
Decreased periparturient transmission of bovine leukosis virus in colostrum-fed calvesDusty W Nagy
Departments of Veterinary Medicine and Surgery, University of Missouri Columbia, Columbia, MO 65211, USA
J Vet Intern Med 21:1104-7. 2007The relation between calf bovine leukosis virus (BLV) infection status and colostrum ingestion is unclear. Two conclusions have been drawn from previous studies. One suggests that colostrum ingestion transmits BLV to neonatal calves...
The effects of bovine colostrum supplementation on body composition and exercise performance in active men and womenJ Antonio
University of Delaware, Sports Science Laboratory, Newark, Delaware 19176, USA
Nutrition 17:243-7. 2001The purpose of this study was to determine the effect of 8 wk of bovine colostrum supplementation on body composition and exercise performance in active men and women...
Bovine colostrum contains immunoglobulin G antibodies against intimin, EspA, and EspB and inhibits hemolytic activity mediated by the type three secretion system of attaching and effacing Escherichia coliDaniel A Vilte
Instituto de Patobiologia, Instituto Nacional de Tecnologia Agropecuaria, Buenos Aires, Argentina
Clin Vaccine Immunol 15:1208-13. 2008..some of which are exported to the host cell via a type three secretion system (TTSS), were identified in bovine colostrum by Western blot analysis. Twenty-seven (77...
Compartmentalization of small ruminant lentivirus between blood and colostrum in infected goatsGiuliano Pisoni
Department of Veterinary Pathology, Hygiene and Public Health, University of Milano, Via Celoria 10, 20133 Milano, Italy
Virology 369:119-30. 2007..SRLV) subtype A (Maedi-Visna virus) and B (caprine arthritis-encephalitis virus) variants was analyzed in colostrum and peripheral blood mononuclear cells of four naturally infected goats...
Cytokines in human colostrum and neonatal jaundiceVincenzo Zanardo
Department of Pediatrics, Padua University, 35128 Padua, Italy
Pediatr Res 62:191-4. 2007..The aim of this study was to investigate whether there is a relationship between cytokine levels in the colostrum of nursing mothers and neonatal jaundice (NJ)...
Colostrinin proline-rich polypeptide complex from ovine colostrum--a long-term study of its efficacy in Alzheimer's diseaseJerzy Leszek
Department of Psychiatry, Medical University of Wrocław, Wrocław, Poland
Med Sci Monit 8:PI93-6. 2002Colostrinin, a proline-rich polypeptide complex (PRP) isolated from ovine colostrum, with immunoregulatory and procognitive properties, has shown positive effects in the treatment of Alzheimer's disease (AD)...
Bovine colostrum prevents bacterial translocation in an intestinal ischemia/reperfusion-injured rat modelHan Sung Choi
Department of Emergency Medicine, Kohwang Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea
J Med Food 12:37-46. 2009This study evaluated whether or not bovine colostrum (BC) is able to treat or prevent intestinal barrier damage, bacterial translocation, and the related systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction ..
Colostrum and milk as risk factors for infection with Mycobacterium avium subspecies paratuberculosis in dairy cattleS S Nielsen
Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegårdsvej 8, DK 1870 Frederiksberg C, Denmark
J Dairy Sci 91:4610-5. 2008..Transmission of MAP occurs primarily via feces and in utero, but MAP can also be excreted in colostrum and milk...
Bovine colostrum modulates cytokine production in human peripheral blood mononuclear cells stimulated with lipopolysaccharide and phytohemagglutininCecilia M Shing
School of Human Movement Studies, University of Queensland, St Lucia, Brisbane, Queensland, Australia
J Interferon Cytokine Res 29:37-44. 2009Bovine colostrum has been shown to influence the cytokine production of bovine leukocytes...
Oropharyngeal administration of colostrum to extremely low birth weight infants: theoretical perspectivesN A Rodriguez
Infant Special Care Unit, Department of Pediatrics, Evanston Hospital, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
J Perinatol 29:1-7. 2009..Own mother's colostrum (OMC) is rich in cytokines and other immune agents that provide bacteriostatic, bacteriocidal, antiviral, anti-..
A strong association between human earwax-type and apocrine colostrum secretion from the mammary glandKiyonori Miura
Department of Obstetrics and Gynaecology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Hum Genet 121:631-3. 2007Here we provided the first genetic evidence for an association between the degree of apocrine colostrum secretion and human earwax type...
Expression of the neonatal Fc receptor (FcRn) in the bovine mammary glandBalazs Mayer
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent Istvan University, PO Box 2, H 1400 Budapest, Hungary
J Dairy Res 72:107-12. 2005In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity...
Risk factors associated with colostrum quality in Norwegian dairy cowsS M Gulliksen
Department of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
J Dairy Sci 91:704-12. 2008The objectives of the present study were to evaluate colostrum quality in Norwegian dairy cows based on IgG content, and to identify associations between possible risk factors and low colostral IgG...
Does sward height grazed by ewes in mid- to late-pregnancy affect indices of colostrum intake by twin and triplet lambs?P R Kenyon
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
N Z Vet J 53:336-9. 2005To determine if sward height grazed by ewes in mid- to late-pregnancy affects subsequent indices of colostrum intake by twin and triplet lambs, and the extent of the variation in colostrums intake between twin and triplet litter-mates.
Inhibition of enteropathogenic Escherichia coli (EPEC) adherence to HEp-2 cells by bovine colostrum and milkP Palmeira
Department of Immunology, , Universidade de So Paulo, So Paulo, Brazil
Allergol Immunopathol (Madr) 29:229-37. 2001..METHODS: the effect of colostrum, milk, and serum from dairy cows on the adherence to EPEC to HEp-2 cells was investigated...
Effects of short-term supplementation of clinoptilolite in colostrum and milk on hematology, serum proteins, performance, and health in neonatal dairy calvesM Mohri
Department of Clinical Sciences and Center of excellence in Ruminant Abortion and Neonatal Mortality, School of Veterinary Medicine, Ferdowsi University of Mashhad, P O Box 91775 1793, Mashhad, Iran
Food Chem Toxicol 46:2112-7. 2008..For test 1 group, clinoptilolite in the concentration of 2% of each colostrum meal was added for 48h and for test 2 group, clinoptilolite in the concentration of 2% was added to each ..
Structural growth, rumen development, and metabolic and immune responses of Holstein male calves fed milk through step-down and conventional methodsM A Khan
Dairy Cattle Research Division, National Livestock Research Institute, Cheonan, 330 880, Republic of Korea
J Dairy Sci 90:3376-87. 2007..In the conventional method, calves (n = 20) were fed colostrum and then milk at a rate of 10% of their BW for the entire period of 44 d...
The transfer of maternal IgE and other immunoglobulins specific for Trichostrongylus colubriformis larval excretory/secretory product to the neonatal lambA Pfeffer
AgResearch Ltd, Wallaceville Animal Research Centre, P O Box 40063, Ward Street, Upper Hutt, New Zealand
Vet Immunol Immunopathol 108:315-23. 2005..Immunoglobulin levels were determined in ewe plasma, colostrum and lamb plasma shortly after birth and before the lambs fed, in lamb plasma 2 days after birth, and lamb plasma,..
Research Grants
- EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSEW Walker; Fiscal Year: 2009..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..
- EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSEW Walker; Fiscal Year: 1993We will study the role of colostrum/breast milk in the host defense of the GI tract...
- Phase II Clinical Trial of Lactoferrin in AsthmaAtul Varadhachary; Fiscal Year: 2005..is a multifunctional immunomodulatory protein found in serum and exocrine secretions such as milk and colostrum where it acts as a component of the primary host defense system...
- EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSEW Allan Walker; Fiscal Year: 2010..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..
- EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSEW Allan Walker; Fiscal Year: 2010..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..
- MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATESDouglas Burrin; Fiscal Year: 2004..4) In utero, the fetal intestine is unresponsive to GLP-2. These hypotheses will be tested using a TPN-fed, colostrum-deprived, neonatal pig model with these aims: Aim 1: Quantify the physiological dose response of GLP-2 on ..
