pituitary adrenal system

Summary

Summary: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.

Top Publications

  1. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
  2. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
  3. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
  4. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
  5. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
  6. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
  7. doi Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals
    Antonio Armario
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neurosci Biobehav Rev 32:1121-35. 2008
  8. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
  9. ncbi Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
  10. ncbi Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003

Research Grants

Detail Information

Publications220 found, 100 shown here

  1. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
    ....
  2. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
    ....
  3. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  4. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  5. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
    ..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
  6. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
    ..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
  7. doi Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals
    Antonio Armario
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neurosci Biobehav Rev 32:1121-35. 2008
    ..This is particularly critical when trying to model post-traumatic stress disorders (PTSD), which demands a great effort to validate such putative models...
  8. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
    ....
  9. ncbi Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
    ..As such, these neurons are positioned to summate limbic inputs into net inhibitory tone on the PVN and may thus play a major role in HPA dysfunction seen in affective disease states and aging...
  10. ncbi Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003
    ..The goal of the present study was to investigate the association of self-reported depressive symptomatology with early morning free cortisol levels and their relationship to measures of stress...
  11. pmc Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
    Nicholas Barden
    Neuroscience Research Department, Centre Hospitalier de l Université Laval Research Centre, Sainte Foy, QC
    J Psychiatry Neurosci 29:185-93. 2004
    ..This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs...
  12. ncbi Corticosteroid insufficiency in acutely ill patients
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    N Engl J Med 348:727-34. 2003
  13. doi Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats
    Greg M Anderson
    Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 150:1834-40. 2009
    ..This effect may include actions of RFRP-3 on GnRH neurons and/or their anteroventral periventricular afferent inputs but is unlikely to involve direct inhibition of LH secretion at the level of the gonadotrope...
  14. pmc Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
    Elizabeth D Kirby
    Helen Wills Neuroscience Institute, University of California Berkeley, 3060 VLSB 3140, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:11324-9. 2009
    ....
  15. ncbi Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
    J Neuroimmunol 126:116-25. 2002
    ..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
  16. pmc Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
    Maureen P Boyle
    Department of Pediatrics, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:473-8. 2005
    ....
  17. ncbi Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
    H J Harris
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:114-20. 2001
    ..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...
  18. ncbi Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica
    M Cutolo
    University of Genova, Genova, Italy
    J Endocrinol Invest 25:19-23. 2002
    ..Given its multifaceted properties, including the ability to counteract the negative side effects of glucocorticoids, the therapeutical administration of DHEA might be considered in these pathologies, provided its safety is proved...
  19. ncbi Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosus
    M A Gutierrez
    Department of Clinical Immunology and Rheumatology, Pontificia Universidad Catolica de Chile, Santiago
    Lupus 7:404-8. 1998
    ..02) and 0-90 min (P = 0.01) after TRH injection. These findings suggest that active SLE is associated with some degree of dysfunction of the hypothalamic-pituitary-glucocorticoid axis and PRL secretion...
  20. ncbi Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges
    B Klimes-Dougan
    Department of Psychology, The Catholic University of America, Washington DC 20064, USA
    Dev Psychopathol 13:695-719. 2001
    ..These and other results suggest that gender is an important moderating factor linking psychopathology. development, and context with HPA axis functioning in adolescence...
  21. ncbi Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids
    B Gudbjornsson
    Department of Medicine, Uppsala University Hospital, Sweden
    J Rheumatol 23:596-602. 1996
    ..To study the hypothalamic-pituitary-adrenal axis in rheumatoid arthritis (RA) and the influence of glucocorticoid treatment...
  22. ncbi Sex differences in HPA axis responses to stress: a review
    Brigitte M Kudielka
    Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
    Biol Psychol 69:113-32. 2005
  23. ncbi Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, National Institute of Health ISS, Viale Regina Elena 299, 00161 Rome, Italy
    Horm Behav 50:667-80. 2006
    ....
  24. ncbi Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  25. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
    ..v. lipopolysaccharide. Thus, altered basal pulse frequency is a major factor influencing HPA activation during acute psychological stress...
  26. ncbi The neurobiology of stress: from serendipity to clinical relevance
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, 10021, New York, NY, USA
    Brain Res 886:172-189. 2000
    ..Stress-induced structural changes in brain regions such as the hippocampus have clinical ramifications for disorders such as depression, post-traumatic stress disorder and individual differences in the aging process...
  27. ncbi Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
  28. ncbi The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent
    Ilona S Federenko
    Department of Clinical and Theoretical Psychobiology, University of Trier, Germany
    J Clin Endocrinol Metab 89:6244-50. 2004
    ..These findings challenge previous reports on a low heritability of markers of stimulated hypothalamus pituitary adrenal axis activity and are the first to document the relevance of context for psychoendocrine heritability estimates...
  29. ncbi Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  30. ncbi Glucocorticoid receptor function in vitro in patients with major depression
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, Denmark Hill, UK
    Stress 7:209-19. 2004
    ....
  31. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000
    ..The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress...
  32. doi Neural regulation of endocrine and autonomic stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
    Nat Rev Neurosci 10:397-409. 2009
    ....
  33. ncbi Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
    ....
  34. ncbi What stress does to your brain: a review of neuroimaging studies
    Katarina Dedovic
    Student, Douglas Mental Health University Institute, Verdun, Quebec
    Can J Psychiatry 54:6-15. 2009
    ..The goal of this review is to, first, summarize results from these studies from a perspective of task design and, second, assess the appropriateness of the different stress tasks used...
  35. pmc Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
    Marni N Silverman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    Viral Immunol 18:41-78. 2005
    ....
  36. ncbi Stress and the female reproductive system
    S N Kalantaridou
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Ioannina, School of Medicine, Panepistimiou Avenue, 45500 Ioannina, Greece
    J Reprod Immunol 62:61-8. 2004
    ..Postpartum, this hypercortisolism is followed by a transient adrenal suppression, which may explain the blues/depression and increased autoimmune phenomena observed during this period...
  37. ncbi Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress
    S Ma
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Neuroendocrinol 17:22-8. 2005
    ....
  38. ncbi Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis
    Stefan M Gold
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neuroimmunol 165:186-91. 2005
    ..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS...
  39. ncbi Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:951-62. 2002
    ..Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests...
  40. ncbi Cortisol pulsatility and its role in stress regulation and health
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, USA
    Front Neuroendocrinol 25:69-76. 2004
    ..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease...
  41. pmc Modulation of stress responses: how we cope with excess glucocorticoids
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143, USA
    Exp Neurol 206:179-82. 2007
  42. ncbi Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components
    J Hellhammer
    Department of Psychobiology, University of Trier, D 54295 Trier, Germany
    Psychoneuroendocrinology 32:80-6. 2007
    ....
  43. doi The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
    Arie G Nieuwenhuizen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Physiol Behav 94:169-77. 2008
    ..In the Western society, with chronically high ambient levels of stress and the availability of high caloric foods, this relationship may imply a risk for the development of (visceral) obesity and the metabolic syndrome...
  44. ncbi Maternal care and the development of stress responses
    D D Francis
    Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology and Neurosurgery 6875 Boul LaSalle McGill University Montréal Canada H4H 1R3
    Curr Opin Neurobiol 9:128-34. 1999
    ....
  45. ncbi Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression
    M Hatzinger
    Psychiatric University Hospital, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    World J Biol Psychiatry 1:105-11. 2000
    ..In conclusion, research in neuroendocrinology provided new insights into the underlying pathophysiology of depression and, in consequence, may lead to the development of new therapeutic tools...
  46. ncbi The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone
    S Schroeder
    , , Bonn, Germany
    Crit Care Med 29:310-6. 2001
    ..In addition, the plasma cortisol response to a single CRH stimulation was impaired in nonsurvivors compared with survivors. Reduced responses to CRH stimulation may reflect a state of endocrinologic organ dysfunction in severe sepsis...
  47. ncbi Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
    ....
  48. ncbi The HPA and immune axes in stress: the involvement of the serotonergic system
    B E Leonard
    Pharmacology Department, National University of Ireland, Galway, Ireland
    Eur Psychiatry 20:S302-6. 2005
    ....
  49. ncbi A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors
    Xavier Belda
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Horm Behav 54:654-61. 2008
    ..Long-term effects of IMO on the susceptibility to stress-induced endocrine and emotional disturbances may be relevant to the characterization of animal models of post-traumatic stress...
  50. ncbi Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
    ..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
  51. ncbi The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
    Nicole M Cameron
    McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Montreal, Que, Canada H4H 1R3
    Neurosci Biobehav Rev 29:843-65. 2005
    ..Ultimately, we will need to contend with the reality that neural development, function and health are defined by social and economic influences...
  52. doi Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice
    L Q Stewart
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, University of Bristol, Bristol, UK
    J Neuroendocrinol 20:597-605. 2008
    ..Furthermore, the normal corticosterone response to repeated exposure to change in environment stress also requires the Avpr1b to drive HPA axis responsiveness...
  53. ncbi When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Psychiatry 160:1554-65. 2003
    ....
  54. ncbi Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  55. pmc Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
    B Czeh
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:12796-801. 2001
    ..These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders...
  56. ncbi Obesity and cortisol
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Goteborg, Sweden
    Nutrition 16:924-36. 2000
    ..The mechanism involved is not known, but available information suggests that programming of the hypothalamic-pituitary-adrenal axis may be responsible...
  57. ncbi The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin
    Anthony P Coll
    Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 145:4721-7. 2004
    ..Although such glands are atrophic and hypofunctional, exposure to ACTH alone can restore their size, morphology, and corticosterone secretion...
  58. ncbi Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
    María Inés Forray
    Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile
    Brain Res Brain Res Rev 47:145-60. 2004
    ....
  59. ncbi Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility?
    Anja C Huizink
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Utrecht, Netherlands
    Psychol Bull 130:115-42. 2004
    ..Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology...
  60. ncbi Cytokines and major depression
    Olga J G Schiepers
    Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:201-17. 2005
    ....
  61. ncbi Importance of studying the contributions of early adverse experience to neurobiological findings in depression
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:641-8. 2004
    ....
  62. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
    ..We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span...
  63. ncbi Adrenal insufficiency in the critically ill: a new look at an old problem
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 122:1784-96. 2002
    ..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
  64. ncbi Major depression and the stress system: a life span perspective
    S E Meyer
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Dev Psychopathol 13:565-80. 2001
    ..The authors highlight the importance of multidisciplinary, longitudinal studies in attempting to gain a deeper understanding of the complex developmental processes involved in the onset and course of depression...
  65. doi The significance of glucocorticoid pulsatility
    Stafford L Lightman
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY
    Eur J Pharmacol 583:255-62. 2008
    ..This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor...
  66. pmc Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Mol Cell Biol 20:9009-17. 2000
    ..Furthermore, they may explain differences in the susceptibility of humans to inflammatory diseases and stress, depending on individual prenatal and postnatal experiences known to influence the expression of the glucocorticoid receptor...
  67. ncbi Neurobiological and psychosocial processes associated with depressive and substance-related disorders in adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Curr Drug Abuse Rev 1:68-80. 2008
    ....
  68. ncbi Sleep and the hypothalamo-pituitary-adrenocortical system
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep Med Rev 6:125-38. 2002
    ..Some data suggest a major effect of light on cortisol secretion. Sleeping is widely associated with blunting and awakenings are linked with increases of HPA hormones...
  69. pmc Hypothalamic involvement in chronic migraine
    M F Peres
    Sao Paulo Headache Center, R Maestro Cardim, 887 01323 001, Sao Paulo SP, Brazil
    J Neurol Neurosurg Psychiatry 71:747-51. 2001
    ..The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion...
  70. ncbi Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  71. ncbi The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease
    Marina O'Kane
    Department of Dermatology, Adelaide and Meath Hospital, Dublin 24, Ireland
    Exp Dermatol 15:143-53. 2006
    ..This stress may be psychological or physical. CRH, produced locally or delivered by peripheral nerves, may mediate interactions between a cutaneous HPA axis-like system and the central HPA axis--the "brain-skin axis"...
  72. ncbi Single nucleotide polymorphisms related to HPA axis reactivity
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Neuroimmunomodulation 16:340-52. 2009
    ..We propose that these genetic variants which modulate HPA axis reactivity are part of the genetic makeup that determines individual stress responsivity and coping style, affecting vulnerability to disease...
  73. ncbi Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, Bessemer Road, SE5 9RS London, UK
    J Psychosom Res 60:145-53. 2006
    ....
  74. ncbi Subjective memory complaints in aging are associated with elevated cortisol levels
    Oliver T Wolf
    Institute for Experimental Psychology, University of Duesseldorf, Germany
    Neurobiol Aging 26:1357-63. 2005
    ..Differences in personality traits or in stress susceptibility might underlie the present findings. Future studies of memory complaints should take a comprehensive approach including relevant endocrine parameters...
  75. ncbi The effects of child maltreatment on the hypothalamic-pituitary-adrenal axis
    Elizabeth Van Voorhees
    Virginia Polytechnic Institute and State University, USA
    Trauma Violence Abuse 5:333-52. 2004
    ....
  76. ncbi Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, 11527 Athens, Greece
    Stress 10:213-9. 2007
    ....
  77. doi Dysregulation of the stress response in asthmatic children
    K N Priftis
    Department of Allergy Pneumonology, Penteli Children s Hospital, P Penteli, Greece
    Allergy 64:18-31. 2009
    ..Few patients may experience further deterioration of adrenal function, a phenomenon which may be genetically determined...
  78. ncbi Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study
    J McBeth
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:360-71. 2007
    ..To test the hypothesis that abnormalities in the hypothalamic-pituitary-adrenal (HPA) stress-response system would act as an effect moderator between HPA function and the onset of chronic widespread pain (CWP)...
  79. doi HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study
    Rianne Marsman
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Psychoneuroendocrinology 33:789-98. 2008
    ..It would be useful to consider how other risk factors such as life events and family and parenting factors as well as genetic risks affect the complex relationship between externalizing behavior problems and HPA-axis activity...
  80. ncbi A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis
    David C Mohr
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94131, USA
    Brain Behav Immun 20:27-36. 2006
    ..These three hypotheses are not necessarily mutually exclusive. Data on psychosocial mediators and moderators are also briefly reviewed and future research directions are discussed...
  81. doi Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor
    Helen C Atkinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Am J Physiol Endocrinol Metab 294:E1011-22. 2008
    ....
  82. ncbi A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans
    Yongwimon Lenbury
    Department of Mathematics, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok 10400, Thailand
    Math Med Biol 22:15-33. 2005
    ....
  83. pmc The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Eur J Pharmacol 583:186-93. 2008
    ..The possible abnormalities of these two systems in depressive illness are also discussed...
  84. ncbi Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls
    Andreas H Böhmelt
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 67:288-94. 2005
    ..The aim of this study was to investigate alterations of pituitary-adrenal activity under both stimulated and unstimulated conditions in patients with functional gastrointestinal disorders...
  85. ncbi Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity...
  86. ncbi Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress
    A J Tilbrook
    Department of Physiology, Monash University, Victoria, Australia
    Front Neuroendocrinol 27:285-307. 2006
    ..The possible roles of inhibitory central inputs to CRH and AVP neurons and of oxytocin and prolactin in attenuating the HPA axis responses to stress are unknown...
  87. ncbi Involvement of the glucocorticoid receptor in the pathogenesis of rheumatoid arthritis
    Gunther Neeck
    Kerckhoff Clinic and Foundation, Bad Nauheim, Germany
    Ann N Y Acad Sci 966:491-5. 2002
    ..These results seem to reflect a functional dysregulation of the HPA axis and may lead to a better understanding of the pathogenesis of RA...
  88. ncbi Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis
    Angelika Buske-Kirschbaum
    Center for Psychobiological and Psychosomatic Research, University of Trier, 54286 Trier, Germany
    J Clin Endocrinol Metab 87:4245-51. 2002
    ....
  89. ncbi Combined stimulation of adrenocorticotropin and compound-S by single dose metyrapone test as an outpatient procedure to assess hypothalamic-pituitary-adrenal function
    K Berneis
    Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine, University Hospitals, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 87:5470-5. 2002
    ..Despite the relatively high cross-reactivity of CMP-S in the cortisol assay, the sum of CMP-S and cortisol levels with a cut-off value of 450 nmol/liter yields a better diagnostic accuracy compared with CMP-S alone...
  90. ncbi Low-dose dexamethasone suppression test in chronic fatigue syndrome and health
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:311-8. 2002
    ..The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome...
  91. ncbi Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 85:257-63. 2003
    ..Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration...
  92. ncbi Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
    Nicolas Rohleder
    Department of Psychology, Institute of Experimental Psychology II, University of Dusseldorf, Dusseldorf, Germany
    Biol Psychiatry 55:745-51. 2004
    ..Alterations include various responses to HPA axis stimulation, different basal hormone levels, and changes in glucocorticoid receptor (GR) numbers on lymphocytes. The functional significance of these latter changes remains elusive...
  93. ncbi Prior stressor exposure primes the HPA axis
    John D Johnson
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 27:353-65. 2002
    ..IS significantly increased plasma CORT 15 min after pedestal exposure, but not after 30 or 60 min. These results suggest that exposure to IS sensitizes the CORT and ACTH response to subsequent HPA activation...
  94. pmc Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation
    N Shanks
    Division of Medicine, University of Bristol, Bristol Royal Infirmary Labs, Marlborough Street, Bristol, BS2 8HW, United Kingdom
    Proc Natl Acad Sci U S A 97:5645-50. 2000
    ..These findings demonstrate a potent and long-term effect of neonatal exposure to inflammatory stimuli that can program major changes in the development of both neuroendocrine and immunological regulatory mechanisms...
  95. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
    ....
  96. ncbi Genetically engineered mice for studies of stress-related clinical conditions
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 36:53-76. 2002
    ....
  97. ncbi Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats
    Vincent Van Waes
    Unité de Neurosciences et Physiologie Adaptatives, Equipe Stress Périnatal, Universite de Lille 1, 59655 Villeneuve d Ascq, France
    Eur J Neurosci 24:1193-200. 2006
    ..They thus raise questions about the possible impact of prenatal stress on the further development of ethanol vulnerability...
  98. ncbi Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, Munich, 80336, Germany
    Psychopharmacology (Berl) 186:601-11. 2006
    ....
  99. ncbi The four-dimensional stress test: psychological, sympathetic-adrenal-medullary, parasympathetic and hypothalamic-pituitary-adrenal responses following inhalation of 35% CO2
    Mark A Wetherell
    MRC Health Services Research Collaboration, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Psychoneuroendocrinology 31:736-47. 2006
    ..The current study was designed, therefore, to assess the psychological and physiological responses to the inhalation of CO2...
  100. ncbi The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
    ..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility...
  101. ncbi Characterization of pituitary-adrenocortical activity in the Malayan flying fox (Pteropus vampyrus)
    Deeann M Reeder
    Department of Biology, Boston University, Boston, MA 02215, USA
    J Comp Physiol B 176:513-9. 2006
    ....

Research Grants99

  1. VASOPRESSIN PATHWAYS AND THE PITUITARY-ADRENAL SYSTEM
    Earl Zimmerman; Fiscal Year: 1980
    ..Portal vs. peripheral VP, ACTH, and CS will also be studied in reference to administration or removal of steroids, brain lesions and neurotransmitters. ..
  2. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1990
    ..This RCDA award will give the candidate the financial support necessary to pursue her research interest as her sole focus in the next 5 years, and to develop her own strong, independent research program...
  3. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2004
    ..A fuller basic understanding of circuits and mechanisms underlying these adaptations will promote more effective management of stress related disease. ..
  4. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2005
    ..A fuller basic understanding of circuits and mechanisms underlying these adaptations will promote more effective management of stress related disease. ..
  5. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2007
    ..A fuller basic understanding of circuits and mechanisms underlying these adaptations will promote more effective management of stress related disease. ..
  6. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2006
    ..A fuller basic understanding of circuits and mechanisms underlying these adaptations will promote more effective management of stress related disease. ..
  7. NEUROCHEMICAL & HORMONAL FACTORS IN STRESS
    ADRIAN DUNN; Fiscal Year: 1990
    ..A comparison of the activation of synthesis in DA and NE terminals during stress will also be made. Finally, the ability of benzodiazepines and of neurotensin to counteract or diminish the stress responses will be examined...
  8. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2012
    ....
  9. Biobehavioral Characterization of Infant Rhesus Monkeys
    John Capitanio; Fiscal Year: 2009
    ....
  10. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2010
    ....
  11. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 1990
    ....
  12. DEVELOPMENTAL AND BEHAVIORAL NEUROENDOCRINOLOGY
    Seymour Levine; Fiscal Year: 1980
    ..Finally, we propose to establish a laboratory model of adolescence by examining behavioral and gonadal hormone changes that occur during puberty in the squirrel monkey...
  13. DEVELOPMENTAL AND BEHAVIORAL NEUROENDOCRINOLOGY
    Seymour Levine; Fiscal Year: 1990
    ..Finally, we propose to establish a laboratory model of adolescence by examining behavioral and gonadal hormone changes that occur during puberty in the squirrel monkey...
  14. HORMONES AND BEHAVIOR
    Seymour Levine; Fiscal Year: 1990
    ..This proposal is an extension of our long-standing interest in developmental neuroendocrinology. Professional growth and development involves learning and using techniques of molecular biology to study psychobiological issues...
  15. EFFECTS OF CANNABINOIDS ON HORMONE ACTION AND CONTROL
    GEORGE FUJIMOTO; Fiscal Year: 1980
    ..Thus, in these studies, we are seeking the site(s) and mode(s) of action of cannabinoids on the androgenic and corticosteroid hormone systems...
  16. Fetal and Neonatal Pituitary-Adrenal Function
    James C Rose; Fiscal Year: 2010
    ....
  17. Fetal and Neonatal Pituitary-Adrenal Function
    James Rose; Fiscal Year: 2009
    ....
  18. Fetal and Neonatal Pituitary-Adrenal Function
    James Rose; Fiscal Year: 2007
    ....
  19. Fetal and Neonatal Pituitary-Adrenal Function
    James Rose; Fiscal Year: 2006
    ....
  20. MATERNAL REGULATION OF INFANT PHYSIOLOGY AND BEHAVIOR
    Seymour Levine; Fiscal Year: 1990
    ..4) To examine whether perinatal maternal deprivation alters neuroendocrine activity and behavior in adulthood...
  21. BIOCHEMICAL PROCESSES IN THE FORMATION OF MEMORY
    ADRIAN DUNN; Fiscal Year: 1980
    ..Other work is aimed at examining interactions between ACTH and other neurotransmitters, e.g., serotonin and polyamines...
  22. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1990
    ..These studies will lead to a better understanding of the normal physiology of the pituitary-adrenal system during pregnancy and may aid in understanding abnormal function in pregnancies complicated by Cushing's syndrome...
  23. THE PSYCHOBIOLOGY OF CHILDHOOD ANXIETY AND DEPRESSION
    Neal Ryan; Fiscal Year: 2000
    ..This program project may lead to better prediction of risk and course and better prevention, treatment, and prophylaxis strategies for depressive and anxiety disorders in children. ..
  24. PSYCHOBIOLOGY OF CHILDHOOD ANXIETY AND DEPRESSION
    Neal Ryan; Fiscal Year: 2001
    ..This program project may lead to better prediction of risk and course and better prevention, treatment, and prophylaxis strategies for depressive and anxiety disorders in children. ..
  25. PSYCHOBIOLOGY OF CHILDHOOD ANXIETY AND DEPRESSION
    Neal Ryan; Fiscal Year: 2000
    ..This program project may lead to better prediction of risk and course and better prevention, treatment, and prophylaxis strategies for depressive and anxiety disorders in children. ..
  26. PSYCHOBIOLOGY OF CHILDHOOD ANXIETY AND DEPRESSION
    Neal Ryan; Fiscal Year: 2002
    ..This program project may lead to better prediction of risk and course and better prevention, treatment, and prophylaxis strategies for depressive and anxiety disorders in children. ..
  27. PSYCHOBIOLOGY OF CHILDHOOD ANXIETY AND DEPRESSION
    Neal Ryan; Fiscal Year: 1999
    ..This program project may lead to better prediction of risk and course and better prevention, treatment, and prophylaxis strategies for depressive and anxiety disorders in children. ..
  28. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2001
    ....
  29. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2000
    ....
  30. NEURAL REGULATION OF ANTERIOR PITUITARY
    B Critchlow; Fiscal Year: 1980
    ..Related projects will study structures mediating stress-induced decreases in GH secretion. A final series of projects will focus on the neural basis for stress-induced alterations in Prl secretion. ..
  31. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 1999
    ....
  32. PSYCHOLOGICAL MODULATION OF STRESS IN AGING
    LINDA BRETT; Fiscal Year: 1980
    ..The indicant of pituitary-adrenal response in each of the proposed experiments will be plasma levels of corticosterone. ..
  33. PRENATAL AND NEONATAL PITUITARY ADRENAL FUNCTION
    James Rose; Fiscal Year: 1980
    ..In addition to the in vivo experiments, results of in vitro studies on adrenal steroid responses to ACTH will be used to investigate possible mechanisms involved in changes in activity which occur during development...
  34. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2002
    ....
  35. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2002
    ....
  36. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2000
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
  37. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 1999
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
  38. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ....
  39. STRESS AND REPRODUCTIVE HORMONES IN DEPRESSION
    Elizabeth Young; Fiscal Year: 2008
    ..This project will evaluate whether women with depression show low estrogen levels and if the changes in estrogen are accompanied by changes in serotonin binding in the brains of women with major depression ..
  40. Effects of comorbid anxiety disorders on the HPA axis profile of depression
    Elizabeth Young; Fiscal Year: 2008
    ..We will also explore if timing of trauma changes the stress hormone response to a public speaking challenge. ..
  41. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
    ....
  42. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2002
    ....
  43. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
  44. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2005
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  45. Biology of Risk of PTSD in Holocaust Survivor Offspring
    Rachel Yehuda; Fiscal Year: 2002
    ..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
  46. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2003
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  47. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2003
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  48. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2006
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
  49. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2007
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  50. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2007
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
  51. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2009
    ....
  52. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2009
    ..abstract_text> ..
  53. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2006
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  54. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2005
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  55. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2004
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  56. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2005
    ..abstract_text> ..
  57. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2005
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  58. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2004
    ....
  59. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2006
    ....
  60. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2004
    ..abstract_text> ..
  61. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2001
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  62. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2004
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  63. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2006
    ..abstract_text> ..
  64. Ensemble Control of ACTH Secretion: Impact of Gender
    Johannes D Veldhuis; Fiscal Year: 2010
    ..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
  65. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2004
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  66. Ensemble Control of ACTH Secretion: Impact of Gender
    Johannes Veldhuis; Fiscal Year: 2009
    ..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
  67. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2006
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  68. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2006
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  69. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2006
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..