pituitary adrenal system

Summary

Summary: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.

Top Publications

  1. ncbi Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
  2. ncbi Sex differences in HPA axis responses to stress: a review
    Brigitte M Kudielka
    Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany
    Biol Psychol 69:113-32. 2005
  3. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
  4. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
  5. ncbi Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599-7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
  6. ncbi Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, National Institute of Health ISS, Viale Regina Elena 299, 00161 Rome, Italy
    Horm Behav 50:667-80. 2006
  7. ncbi Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
  8. ncbi Neural regulation of endocrine and autonomic stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
    Nat Rev Neurosci 10:397-409. 2009
  9. ncbi Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
  10. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000

Research Grants

  1. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2007
  2. Biobehavioral Characterization of Infant Rhesus Monkeys
    John Capitanio; Fiscal Year: 2009
  3. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2010
  4. Fetal and Neonatal Pituitary-Adrenal Function
    James C Rose; Fiscal Year: 2010
  5. Fetal and Neonatal Pituitary-Adrenal Function
    James Rose; Fiscal Year: 2007
  6. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1990
  7. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2002
  8. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
  9. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
  10. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001

Detail Information

Publications190 found, 100 shown here

  1. ncbi Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  2. ncbi Sex differences in HPA axis responses to stress: a review
    Brigitte M Kudielka
    Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany
    Biol Psychol 69:113-32. 2005
  3. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
    ..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
  4. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
    ..v. lipopolysaccharide. Thus, altered basal pulse frequency is a major factor influencing HPA activation during acute psychological stress...
  5. ncbi Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599-7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..CONCLUSIONS: These results suggest that DOC levels in monkeys are regulated by the HPA axis and may contribute to physiological responses following activation...
  6. ncbi Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, National Institute of Health ISS, Viale Regina Elena 299, 00161 Rome, Italy
    Horm Behav 50:667-80. 2006
    ....
  7. ncbi Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
    ....
  8. ncbi Neural regulation of endocrine and autonomic stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
    Nat Rev Neurosci 10:397-409. 2009
    ....
  9. ncbi Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
    ..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
  10. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000
    ..The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress...
  11. ncbi Maternal care and the development of stress responses
    D D Francis
    Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology and Neurosurgery 6875 Boul LaSalle McGill University Montréal Canada H4H 1R3
    Curr Opin Neurobiol 9:128-34. 1999
    ....
  12. ncbi Sleep and the hypothalamo-pituitary-adrenocortical system
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep Med Rev 6:125-38. 2002
    ..Some data suggest a major effect of light on cortisol secretion. Sleeping is widely associated with blunting and awakenings are linked with increases of HPA hormones...
  13. ncbi Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress
    S Ma
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Neuroendocrinol 17:22-8. 2005
    ....
  14. ncbi The HPA and immune axes in stress: the involvement of the serotonergic system
    B E Leonard
    Pharmacology Department, National University of Ireland, Galway, Ireland
    Eur Psychiatry 20:S302-6. 2005
    ....
  15. ncbi A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors
    Xavier Belda
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Horm Behav 54:654-61. 2008
    ..Long-term effects of IMO on the susceptibility to stress-induced endocrine and emotional disturbances may be relevant to the characterization of animal models of post-traumatic stress...
  16. ncbi Stress and the female reproductive system
    S N Kalantaridou
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Ioannina, School of Medicine, Panepistimiou Avenue, 45500 Ioannina, Greece
    J Reprod Immunol 62:61-8. 2004
    ..Postpartum, this hypercortisolism is followed by a transient adrenal suppression, which may explain the blues/depression and increased autoimmune phenomena observed during this period...
  17. ncbi The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone
    S Schroeder
    , , Bonn, Germany
    Crit Care Med 29:310-6. 2001
    ..In addition, the plasma cortisol response to a single CRH stimulation was impaired in nonsurvivors compared with survivors. Reduced responses to CRH stimulation may reflect a state of endocrinologic organ dysfunction in severe sepsis...
  18. ncbi Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression
    M Hatzinger
    Psychiatric University Hospital, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    World J Biol Psychiatry 1:105-11. 2000
    ..In conclusion, research in neuroendocrinology provided new insights into the underlying pathophysiology of depression and, in consequence, may lead to the development of new therapeutic tools...
  19. ncbi Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  20. ncbi The significance of glucocorticoid pulsatility
    Stafford L Lightman
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY
    Eur J Pharmacol 583:255-62. 2008
    ..This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor...
  21. ncbi Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
  22. ncbi Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosus
    M A Gutierrez
    Department of Clinical Immunology and Rheumatology, Pontificia Universidad Catolica de Chile, Santiago
    Lupus 7:404-8. 1998
    ..02) and 0-90 min (P = 0.01) after TRH injection. These findings suggest that active SLE is associated with some degree of dysfunction of the hypothalamic-pituitary-glucocorticoid axis and PRL secretion...
  23. ncbi Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
    ....
  24. ncbi Adrenal insufficiency in the critically ill: a new look at an old problem
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 122:1784-96. 2002
    ..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
  25. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
    ..We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span...
  26. ncbi Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
    Nicholas Barden
    Neuroscience Research Department, Centre Hospitalier de l Université Laval Research Centre, Sainte Foy, QC
    J Psychiatry Neurosci 29:185-93. 2004
    ..This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs...
  27. ncbi The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin
    Anthony P Coll
    Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 145:4721-7. 2004
    ..Although such glands are atrophic and hypofunctional, exposure to ACTH alone can restore their size, morphology, and corticosterone secretion...
  28. ncbi Cytokines and major depression
    Olga J G Schiepers
    Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:201-17. 2005
    ....
  29. ncbi Importance of studying the contributions of early adverse experience to neurobiological findings in depression
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:641-8. 2004
    ....
  30. ncbi Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility?
    Anja C Huizink
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Utrecht, Netherlands
    Psychol Bull 130:115-42. 2004
    ..Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology...
  31. ncbi Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
    María Inés Forray
    Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile
    Brain Res Brain Res Rev 47:145-60. 2004
    ....
  32. ncbi Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
    Nicolas Rohleder
    Department of Psychology, Institute of Experimental Psychology II, , , Germany
    Biol Psychiatry 55:745-51. 2004
    ..Whether this pattern reflects an adaptive mechanism and whether this is sufficient to protect from detrimental effects of low cortisol remains to be investigated...
  33. ncbi Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress
    A J Tilbrook
    Department of Physiology, Monash University, Victoria, Australia
    Front Neuroendocrinol 27:285-307. 2006
    ..The possible roles of inhibitory central inputs to CRH and AVP neurons and of oxytocin and prolactin in attenuating the HPA axis responses to stress are unknown...
  34. ncbi The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease
    Marina O'Kane
    Department of Dermatology, Adelaide and Meath Hospital, Dublin 24, Ireland
    Exp Dermatol 15:143-53. 2006
    ..This stress may be psychological or physical. CRH, produced locally or delivered by peripheral nerves, may mediate interactions between a cutaneous HPA axis-like system and the central HPA axis--the "brain-skin axis"...
  35. ncbi Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
    Mariangela Serra
    Department of Experimental Biology, Center of Excellence for Neurobiology of Drug Dependence, University of Cagliari, Cagliari, Italy
    J Neurochem 85:257-63. 2003
    ..Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration...
  36. ncbi Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, 11527 Athens, Greece
    Stress 10:213-9. 2007
    ....
  37. ncbi The effects of child maltreatment on the hypothalamic-pituitary-adrenal axis
    Elizabeth Van Voorhees
    Virginia Polytechnic Institute and State University, USA
    Trauma Violence Abuse 5:333-52. 2004
    ....
  38. ncbi Subjective memory complaints in aging are associated with elevated cortisol levels
    Oliver T Wolf
    Institute for Experimental Psychology, University of Duesseldorf, Germany
    Neurobiol Aging 26:1357-63. 2005
    ..Differences in personality traits or in stress susceptibility might underlie the present findings. Future studies of memory complaints should take a comprehensive approach including relevant endocrine parameters...
  39. ncbi Glucocorticoid receptor function in vitro in patients with major depression
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, Denmark Hill, UK
    Stress 7:209-19. 2004
    ....
  40. ncbi Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis
    Stefan M Gold
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neuroimmunol 165:186-91. 2005
    ..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS...
  41. ncbi Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..e. in the absence of characteristic differences in reproductive steroids)...
  42. ncbi Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
    Marni N Silverman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    Viral Immunol 18:41-78. 2005
    ....
  43. ncbi Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls
    Andreas H Böhmelt
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 67:288-94. 2005
    ..The aim of this study was to investigate alterations of pituitary-adrenal activity under both stimulated and unstimulated conditions in patients with functional gastrointestinal disorders...
  44. ncbi A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans
    Yongwimon Lenbury
    Department of Mathematics, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok 10400, Thailand
    Math Med Biol 22:15-33. 2005
    ....
  45. ncbi Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study
    J McBeth
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:360-71. 2007
    ..To test the hypothesis that abnormalities in the hypothalamic-pituitary-adrenal (HPA) stress-response system would act as an effect moderator between HPA function and the onset of chronic widespread pain (CWP)...
  46. ncbi A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis
    David C Mohr
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94131, USA
    Brain Behav Immun 20:27-36. 2006
    ..These three hypotheses are not necessarily mutually exclusive. Data on psychosocial mediators and moderators are also briefly reviewed and future research directions are discussed...
  47. ncbi Cortisol pulsatility and its role in stress regulation and health
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, USA
    Front Neuroendocrinol 25:69-76. 2004
    ..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease...
  48. ncbi Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, Bessemer Road, SE5 9RS London, UK
    J Psychosom Res 60:145-53. 2006
    ....
  49. ncbi Corticosteroid insufficiency in acutely ill patients
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    N Engl J Med 348:727-34. 2003
  50. ncbi HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study
    Rianne Marsman
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Psychoneuroendocrinology 33:789-98. 2008
    ..It would be useful to consider how other risk factors such as life events and family and parenting factors as well as genetic risks affect the complex relationship between externalizing behavior problems and HPA-axis activity...
  51. ncbi Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges
    B Klimes-Dougan
    Department of Psychology, The Catholic University of America, Washington DC 20064, USA
    Dev Psychopathol 13:695-719. 2001
    ..These and other results suggest that gender is an important moderating factor linking psychopathology. development, and context with HPA axis functioning in adolescence...
  52. ncbi Prior stressor exposure primes the HPA axis
    John D Johnson
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Psychoneuroendocrinology 27:353-65. 2002
    ..IS significantly increased plasma CORT 15 min after pedestal exposure, but not after 30 or 60 min. These results suggest that exposure to IS sensitizes the CORT and ACTH response to subsequent HPA activation...
  53. ncbi Low-dose dexamethasone suppression test in chronic fatigue syndrome and health
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:311-8. 2002
    ..The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome...
  54. ncbi Involvement of the glucocorticoid receptor in the pathogenesis of rheumatoid arthritis
    Gunther Neeck
    Kerckhoff Clinic and Foundation, Bad Nauheim, Germany
    Ann N Y Acad Sci 966:491-5. 2002
    ..These results seem to reflect a functional dysregulation of the HPA axis and may lead to a better understanding of the pathogenesis of RA...
  55. ncbi Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation
    N Shanks
    Division of Medicine, University of Bristol, Bristol Royal Infirmary Labs, Marlborough Street, Bristol, BS2 8HW, United Kingdom
    Proc Natl Acad Sci U S A 97:5645-50. 2000
    ..These findings demonstrate a potent and long-term effect of neonatal exposure to inflammatory stimuli that can program major changes in the development of both neuroendocrine and immunological regulatory mechanisms...
  56. ncbi Combined stimulation of adrenocorticotropin and compound-S by single dose metyrapone test as an outpatient procedure to assess hypothalamic-pituitary-adrenal function
    K Berneis
    Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine, University Hospitals, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 87:5470-5. 2002
    ..Despite the relatively high cross-reactivity of CMP-S in the cortisol assay, the sum of CMP-S and cortisol levels with a cut-off value of 450 nmol/liter yields a better diagnostic accuracy compared with CMP-S alone...
  57. ncbi The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Eur J Pharmacol 583:186-93. 2008
    ..The possible abnormalities of these two systems in depressive illness are also discussed...
  58. ncbi Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor
    Helen C Atkinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Am J Physiol Endocrinol Metab 294:E1011-22. 2008
    ....
  59. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  60. ncbi Dysregulation of the stress response in asthmatic children
    K N Priftis
    Department of Allergy Pneumonology, Penteli Children s Hospital, P Penteli, Greece
    Allergy 64:18-31. 2009
    ..Few patients may experience further deterioration of adrenal function, a phenomenon which may be genetically determined...
  61. ncbi Single nucleotide polymorphisms related to HPA axis reactivity
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Neuroimmunomodulation 16:340-52. 2009
    ..We propose that these genetic variants which modulate HPA axis reactivity are part of the genetic makeup that determines individual stress responsivity and coping style, affecting vulnerability to disease...
  62. ncbi Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis
    Angelika Buske-Kirschbaum
    Center for Psychobiological and Psychosomatic Research, University of Trier, 54286 Trier, Germany
    J Clin Endocrinol Metab 87:4245-51. 2002
    ....
  63. ncbi Depression and stress reactivity in metastatic breast cancer
    Janine Giese-Davis
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Psychosom Med 68:675-83. 2006
    ..This study investigated how depression affects MBC stress reactivity, including autonomic (ANS) and hypothalamic-pituitary-adrenal (HPA) axis function...
  64. ncbi The potential influence of maternal stress hormones on development and mental health of the offspring
    Marta Weinstock
    Department of Pharmacology, School of Pharmacy, Hebrew University Medical Centre Jerusalem, Israel
    Brain Behav Immun 19:296-308. 2005
    ..Excess amounts of CRH and cortisol reaching the human fetal brain during periods of chronic maternal stress could alter personality and predispose to attention deficits and depressive illness through changes in neurotransmitter activity...
  65. ncbi Parity does not alter baseline or stimulated activity of the hypothalamus-pituitary-adrenal axis in women
    Ilona S Federenko
    Department of Psychology and Social Behavior, University of California, Irvine, 3340 Social Ecology II, Irvine, CA 92697 7085, USA
    Dev Psychobiol 48:703-11. 2006
    ....
  66. ncbi HPA axis reactivity and lymphocyte glucocorticoid sensitivity in fibromyalgia syndrome and chronic pelvic pain
    Katja Wingenfeld
    Department of Psychobiology, University of Trier, Trier, Germany
    Psychosom Med 70:65-72. 2008
    ..We tested the hypothesis of reduced cortisol release in response to a psychosocial stressor and pharmacological stimulation. Furthermore, glucocorticoid (GC) sensitivity was evaluated...
  67. ncbi Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation
    Sudie E Back
    Department of Psychiatry, Clinical Neuroscience Division, Medical University of South Carolina, 67 President Street, PO Box 250861, Charleston, SC, USA
    Psychoneuroendocrinology 33:560-8. 2008
    ..In addition, there is some evidence for a more robust neuroendocrine and physiologic response to acute laboratory stress in women as compared to men...
  68. ncbi Gonadal steroid modulation of the limbic-hypothalamic- pituitary-adrenal (LHPA) axis is influenced by social status in female rhesus monkeys
    Mark E Wilson
    Yerkes National Primate Research Center and Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30322, USA
    Endocrine 26:89-97. 2005
    ..Plasma levels of cortisol were significantly higher during E2 replacement compared to the other treatment conditions following DEX suppression and stimulation with CRF...
  69. ncbi The dex/CRH test--is it better than the DST?
    Stuart Watson
    School of Neurology, Neurobiology and Psychiatry, The Stanley Research Centre, University of Newcastle upon Tyne, Leazes Wing Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Psychoneuroendocrinology 31:889-94. 2006
    ..9% and the specificity 71.4%. The sensitivity of 1500 h cortisol (the DST) was 66.6% and the specificity was 47.6%. This suggests that the two tests measure common pathology but that the dex/CRH test has better diagnostic utility...
  70. ncbi Characterization of central and peripheral components of the hypothalamus-pituitary-adrenal axis in the inbred Roman rat strains
    Javier Carrasco
    Unitat de Fisiologia Animal, Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Psychoneuroendocrinology 33:437-45. 2008
    ....
  71. ncbi Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
    H J Harris
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:114-20. 2001
    ..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...
  72. ncbi Major depressive disorder
    R H Belmaker
    Ben Gurion University of the Negev, Beersheba, Israel
    N Engl J Med 358:55-68. 2008
  73. ncbi Salivary cortisol determined by enzyme immunoassay is preferable to serum total cortisol for assessment of dynamic hypothalamic--pituitary--adrenal axis activity
    W S Gozansky
    Division of Geriatric Medicine, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Clin Endocrinol (Oxf) 63:336-41. 2005
    ..Thus, an advantage of measuring salivary cortisol rather than total serum cortisol is that it eliminates the need to account for within-subject changes or between-subject differences in CBG...
  74. ncbi Timing of fetal exposure to stress hormones: effects on newborn physical and neuromuscular maturation
    Lauren M Ellman
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 23, New York, New York 10032, USA
    Dev Psychobiol 50:232-41. 2008
    ..Findings suggest that stress hormones have effects on human fetal neurodevelopment that are independent of birth outcome...
  75. ncbi Can stress cause depression?
    Herman M van Praag
    Department of Psychiatry and Neuropsychology, Academic Hospital Maastricht, and the Brain and Behavior Research Institute, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    World J Biol Psychiatry 6:5-22. 2005
    ..Treatment of stress-inducible depressions and particularly its prevention should be geared towards reduction of stress and stress sensitiveness, utilising both biological and psychological means...
  76. ncbi The neuroendocrinology of stress: a never ending story
    S L Lightman
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    J Neuroendocrinol 20:880-4. 2008
    ....
  77. ncbi Time course of hypothalamic-pituitary-adrenocortical axis activity during treatment with reboxetine and mirtazapine in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, Munich, 80336, Germany
    Psychopharmacology (Berl) 186:601-11. 2006
    ....
  78. ncbi The four-dimensional stress test: psychological, sympathetic-adrenal-medullary, parasympathetic and hypothalamic-pituitary-adrenal responses following inhalation of 35% CO2
    Mark A Wetherell
    MRC Health Services Research Collaboration, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Psychoneuroendocrinology 31:736-47. 2006
    ..The current study was designed, therefore, to assess the psychological and physiological responses to the inhalation of CO2...
  79. ncbi Characterization of pituitary-adrenocortical activity in the Malayan flying fox (Pteropus vampyrus)
    Deeann M Reeder
    Department of Biology, Boston University, Boston, MA 02215, USA
    J Comp Physiol B 176:513-9. 2006
    ....
  80. ncbi Impact of stressors in a natural context on release of cortisol in healthy adult humans: a meta-analysis
    Kathy Michaud
    Department of Psychology, Carleton University, Ottawa, Ont, Canada
    Stress 11:177-97. 2008
    ..Nevertheless, there are ample data suggesting that stressful events, through their actions on cortisol levels and reactivity, may influence psychological and physical pathology...
  81. ncbi Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats
    Vincent Van Waes
    , , , 59655 Villeneuve d'Ascq, France
    Eur J Neurosci 24:1193-200. 2006
    ..They thus raise questions about the possible impact of prenatal stress on the further development of ethanol vulnerability...
  82. ncbi The hypothalamic-pituitary-adrenal axis in critical illness
    Karen L Johnson
    School of Nursing, University of Maryland, Baltimore, 21201, USA
    AACN Clin Issues 17:39-49. 2006
    ..The review in this article will illustrate how adrenal dysfunction presents in critically ill patients and how appropriate diagnosis and management can be achieved in the critical care setting...
  83. ncbi An investigation of hypothalamic-pituitary-adrenal axis hyperactivity in anorexia nervosa: the role of CRH and AVP
    Frances Connan
    Institute of Psychiatry, KCL, London, SE5 8AF, UK
    J Psychiatr Res 41:131-43. 2007
    ..The powerful anorexigenic effect of CRH could contribute to the severity of weight loss associated with AN...
  84. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
    ....
  85. ncbi HPA axis functioning associated with transition to psychosis: combined DEX/CRH test
    K N Thompson
    ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Poplar Road, Locked Bag 10, Parkville, Victoria 3052, Australia
    J Psychiatr Res 41:446-50. 2007
    ....
  86. ncbi Prenatal exposure to dexamethasone alters hippocampal drive on hypothalamic-pituitary-adrenal axis activity in adult male rats
    Jennifer A Shoener
    Biology Dept, Bucknell Univ, Lewisburg, PA 17837, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1366-73. 2006
    ..Taken together, these data demonstrate that late-gestation DEX exposure in rats is associated with persistent changes in both the modulation of HPA axis activity and the HPA axis-mediated response to stress...
  87. ncbi Temperament and response to the Trier Social Stress Test
    A R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Brown Medical School, Providence, RI 02906, USA
    Acta Psychiatr Scand 115:395-402. 2007
    ..The present study tested the association between temperament and HPA axis function in the same group of subjects using a standardized psychosocial neuroendocrine stress test...
  88. ncbi The effect of confinement during lactation on the hypothalamic-pituitary-adrenal axis and behaviour of primiparous sows
    Susan Jarvis
    Animal Behaviour and Welfare, Sustainable Livestock Systems, Scottish Agricultural College, West Mains Road, Edinburgh, EH9 3JG, UK
    Physiol Behav 87:345-52. 2006
    ..Cortisol/ACTH ratio following CRH challenge also tended to be higher in the crate treatments (C and CS) by day 29. These data suggest that prolonged confinement in farrowing crates may have a negative impact on sow welfare...
  89. ncbi Endocrine and behavioural plasticity in response to juvenile stress in the semi-precocial rodent Octodon degus
    M Gruss
    Department of Zoology Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Psychoneuroendocrinology 31:361-72. 2006
    ..These findings support the role of the hypothalamic-pituitary-adrenal axis as one of the key factors mediating the effects of early life stress on the neuronal network and behaviour in O. degus...
  90. ncbi Panic comorbidity with bipolar disorder: what is the manic-panic connection?
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Bipolar Disord 8:648-64. 2006
    ..As both are episodic disorders of affect regulation, the common pathophysiological mechanism is likely to involve deficits in amygdala-mediated, plasticity-dependent emotional conditioning...
  91. ncbi Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone
    A Gesing
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, 80804 Munich, Germany
    J Neurosci 21:4822-9. 2001
    ..We conclude that the interaction between CRH and MR presents a novel mechanism involved in the adaptation of the brain to psychologically stressful events...
  92. ncbi Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence
    J O Workel
    Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, Division of Medical Pharmacology, University of Leiden, Leiden, The Netherlands
    J Neuroendocrinol 13:569-80. 2001
    ..The deprivation effect culminates in a midlife corticosterone surge and results at senescence in a strongly reduced corticosterone output...
  93. ncbi Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: Studies using the corticotrophin-releasing hormone test
    Alexandra M V Ward
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southhampton, UK
    Metabolism 53:720-6. 2004
    ..We therefore found no evidence to suggest that exaggerated pituitary responsiveness or increased central drive to the pituitary, as determined by CRH testing, plays a part in the development of the metabolic syndrome...
  94. ncbi Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia
    Elaine Walker
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Annu Rev Clin Psychol 4:189-216. 2008
    ....
  95. ncbi Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  96. ncbi Comment: the corticotropin-releasing hormone stimulation test in white coat hypertension
    Isao Tabeta
    First Department of Internal Medicine, Toho University School of Medicine, Ota-ku, Tokyo 143-0015, Japan
    J Clin Endocrinol Metab 87:3672-5. 2002
    ..01). These significant responses suggest that white coat hypertension is associated with hypothalamic-pituitary-adrenal hypersensitivity to stressors...
  97. ncbi Disinhibition of female sexual behavior by a CRH receptor antagonist in Syrian hamsters
    Juli E Jones
    Center for Neuroendocrine Studies, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Am J Physiol Regul Integr Comp Physiol 283:R591-7. 2002
    ..This is the first direct evidence that CRH receptor signaling may be a final common pathway by which undernutrition and other conditions inhibit female sexual behavior...
  98. ncbi Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats
    A Raone
    Department of Neuroscience, Pharmacology Unit, University of Siena, Via A Moro 4, 53100 Siena, Italy
    Neuroscience 146:1734-42. 2007
    ....
  99. ncbi Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses
    Ellen Kanitz
    Research Unit Behavioural Physiology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Brain Behav Immun 18:35-45. 2004
    ..Using the pig as a suitable animal model, the finding of this study may also have some implications for the etiology of anxiety and depression in humans...
  100. ncbi Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone
    Rachel Yehuda
    The Traumatic Stress Studies Program of the Mount Sinai School of Medicine and Bronx Veterans Affairs, New York, NY 10468, USA
    J Psychiatr Res 37:471-7. 2003
    ....
  101. ncbi Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone
    Andreas Schuld
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804, Munich, Germany
    J Psychiatr Res 37:463-70. 2003
    ..However, the responsivity of the cytokine production to acutely administered glucocorticoids does not seem to correlate with the state of the HPA system...

Research Grants98

  1. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2007
    ..A fuller basic understanding of circuits and mechanisms underlying these adaptations will promote more effective management of stress related disease. ..
  2. Biobehavioral Characterization of Infant Rhesus Monkeys
    John Capitanio; Fiscal Year: 2009
    ....
  3. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2010
    ....
  4. Fetal and Neonatal Pituitary-Adrenal Function
    James C Rose; Fiscal Year: 2010
    ....
  5. Fetal and Neonatal Pituitary-Adrenal Function
    James Rose; Fiscal Year: 2007
    ....
  6. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1990
    ..These studies will lead to a better understanding of the normal physiology of the pituitary-adrenal system during pregnancy and may aid in understanding abnormal function in pregnancies complicated by Cushing's syndrome...
  7. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2002
    ....
  8. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
    ....
  9. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ....
  10. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
  11. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2007
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
  12. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2007
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  13. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2009
    ....
  14. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2006
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  15. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2006
    ....
  16. Ensemble Control of ACTH Secretion: Impact of Gender
    Johannes D Veldhuis; Fiscal Year: 2010
    ..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
  17. Ensemble Control of ACTH Secretion: Impact of Gender
    Johannes Veldhuis; Fiscal Year: 2009
    ..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
  18. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2006
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..