pituitary adrenal system

Summary

Summary: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.

Top Publications

  1. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
  2. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
  3. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
  4. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
  5. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
  6. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
  7. ncbi Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
  8. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
  9. ncbi Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals
    Antonio Armario
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neurosci Biobehav Rev 32:1121-35. 2008
  10. ncbi Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003

Research Grants

  1. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2013
  2. Fetal and Neonatal Pituitary-Adrenal Function
    James C Rose; Fiscal Year: 2010
  3. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1993
  4. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2007
  5. NEUROCHEMICAL & HORMONAL FACTORS IN STRESS
    ADRIAN DUNN; Fiscal Year: 1990
  6. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 1992
  7. DEVELOPMENTAL AND BEHAVIORAL NEUROENDOCRINOLOGY
    Seymour Levine; Fiscal Year: 1990
  8. PSYCHOLOGICAL MODULATION OF STRESS IN AGING
    LINDA BRETT; Fiscal Year: 1980
  9. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2002
  10. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003

Detail Information

Publications233 found, 100 shown here

  1. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
    ....
  2. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
    ....
  3. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  4. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  5. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
    ..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
  6. ncbi Is the cortisol awakening rise a response to awakening?
    Ines Wilhelm
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:358-66. 2007
    ..Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition...
  7. ncbi Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
    ..As such, these neurons are positioned to summate limbic inputs into net inhibitory tone on the PVN and may thus play a major role in HPA dysfunction seen in affective disease states and aging...
  8. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
    ....
  9. ncbi Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals
    Antonio Armario
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neurosci Biobehav Rev 32:1121-35. 2008
    ..This is particularly critical when trying to model post-traumatic stress disorders (PTSD), which demands a great effort to validate such putative models...
  10. ncbi Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003
    ..The goal of the present study was to investigate the association of self-reported depressive symptomatology with early morning free cortisol levels and their relationship to measures of stress...
  11. ncbi Corticosteroid insufficiency in acutely ill patients
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    N Engl J Med 348:727-34. 2003
  12. pmc Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
    Nicholas Barden
    Neuroscience Research Department, Centre Hospitalier de l Université Laval Research Centre, Sainte Foy, QC
    J Psychiatry Neurosci 29:185-93. 2004
    ..This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs...
  13. pmc Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
    Elizabeth D Kirby
    Helen Wills Neuroscience Institute, University of California Berkeley, 3060 VLSB 3140, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:11324-9. 2009
    ....
  14. ncbi Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats
    Greg M Anderson
    Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 150:1834-40. 2009
    ..This effect may include actions of RFRP-3 on GnRH neurons and/or their anteroventral periventricular afferent inputs but is unlikely to involve direct inhibition of LH secretion at the level of the gonadotrope...
  15. ncbi Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice
    H J Harris
    Molecular Endocrinology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, United Kingdom
    Endocrinology 142:114-20. 2001
    ..Thus 11beta-HSD-1 amplifies glucocorticoid feedback on the HPA axis and is an important regulator of neuronal glucocorticoid exposure under both basal and stress conditions in vivo...
  16. pmc Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
    Maureen P Boyle
    Department of Pediatrics, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:473-8. 2005
    ....
  17. ncbi Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosus
    M A Gutierrez
    Department of Clinical Immunology and Rheumatology, Pontificia Universidad Catolica de Chile, Santiago
    Lupus 7:404-8. 1998
    ..02) and 0-90 min (P = 0.01) after TRH injection. These findings suggest that active SLE is associated with some degree of dysfunction of the hypothalamic-pituitary-glucocorticoid axis and PRL secretion...
  18. ncbi Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary cortisol basal levels, diurnal variation, and responses to social challenges
    B Klimes-Dougan
    Department of Psychology, The Catholic University of America, Washington DC 20064, USA
    Dev Psychopathol 13:695-719. 2001
    ..These and other results suggest that gender is an important moderating factor linking psychopathology. development, and context with HPA axis functioning in adolescence...
  19. ncbi Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids
    B Gudbjornsson
    Department of Medicine, Uppsala University Hospital, Sweden
    J Rheumatol 23:596-602. 1996
    ..To study the hypothalamic-pituitary-adrenal axis in rheumatoid arthritis (RA) and the influence of glucocorticoid treatment...
  20. ncbi Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
    J Neuroimmunol 126:116-25. 2002
    ..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
  21. ncbi Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica
    M Cutolo
    University of Genova, Genova, Italy
    J Endocrinol Invest 25:19-23. 2002
    ..Given its multifaceted properties, including the ability to counteract the negative side effects of glucocorticoids, the therapeutical administration of DHEA might be considered in these pathologies, provided its safety is proved...
  22. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
    ..v. lipopolysaccharide. Thus, altered basal pulse frequency is a major factor influencing HPA activation during acute psychological stress...
  23. ncbi Sex differences in HPA axis responses to stress: a review
    Brigitte M Kudielka
    Department of Clinical and Theoretical Psychobiology, University of Trier, Johanniterufer 15, D 54290 Trier, Germany
    Biol Psychol 69:113-32. 2005
  24. ncbi Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  25. ncbi Developmental plasticity of HPA and fear responses in rats: a critical review of the maternal mediation hypothesis
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, National Institute of Health ISS, Viale Regina Elena 299, 00161 Rome, Italy
    Horm Behav 50:667-80. 2006
    ....
  26. ncbi The neurobiology of stress: from serendipity to clinical relevance
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, 10021, New York, NY, USA
    Brain Res 886:172-189. 2000
    ..Stress-induced structural changes in brain regions such as the hippocampus have clinical ramifications for disorders such as depression, post-traumatic stress disorder and individual differences in the aging process...
  27. ncbi Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
  28. ncbi Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  29. ncbi Glucocorticoid receptor function in vitro in patients with major depression
    Carmine M Pariante
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Division of Psychological Medicine, Institute of Psychiatry, King s College London, Denmark Hill, UK
    Stress 7:209-19. 2004
    ....
  30. ncbi The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent
    Ilona S Federenko
    Department of Clinical and Theoretical Psychobiology, University of Trier, Germany
    J Clin Endocrinol Metab 89:6244-50. 2004
    ..These findings challenge previous reports on a low heritability of markers of stimulated hypothalamus pituitary adrenal axis activity and are the first to document the relevance of context for psychoendocrine heritability estimates...
  31. pmc Neural regulation of endocrine and autonomic stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
    Nat Rev Neurosci 10:397-409. 2009
    ....
  32. ncbi Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
    ....
  33. pmc Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
    Marni N Silverman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
    Viral Immunol 18:41-78. 2005
    ....
  34. ncbi What stress does to your brain: a review of neuroimaging studies
    Katarina Dedovic
    Student, Douglas Mental Health University Institute, Verdun, Quebec
    Can J Psychiatry 54:6-15. 2009
    ..The goal of this review is to, first, summarize results from these studies from a perspective of task design and, second, assess the appropriateness of the different stress tasks used...
  35. ncbi Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress
    S Ma
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Neuroendocrinol 17:22-8. 2005
    ....
  36. ncbi Stress and the female reproductive system
    S N Kalantaridou
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Ioannina, School of Medicine, Panepistimiou Avenue, 45500 Ioannina, Greece
    J Reprod Immunol 62:61-8. 2004
    ..Postpartum, this hypercortisolism is followed by a transient adrenal suppression, which may explain the blues/depression and increased autoimmune phenomena observed during this period...
  37. ncbi Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:951-62. 2002
    ..Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests...
  38. ncbi Cortisol pulsatility and its role in stress regulation and health
    Elizabeth A Young
    Department of Psychiatry, The University of Michigan, USA
    Front Neuroendocrinol 25:69-76. 2004
    ..In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease...
  39. ncbi The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
    Arie G Nieuwenhuizen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Physiol Behav 94:169-77. 2008
    ..In the Western society, with chronically high ambient levels of stress and the availability of high caloric foods, this relationship may imply a risk for the development of (visceral) obesity and the metabolic syndrome...
  40. pmc Modulation of stress responses: how we cope with excess glucocorticoids
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143, USA
    Exp Neurol 206:179-82. 2007
  41. ncbi Maternal care and the development of stress responses
    D D Francis
    Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology and Neurosurgery 6875 Boul LaSalle McGill University Montréal Canada H4H 1R3
    Curr Opin Neurobiol 9:128-34. 1999
    ....
  42. ncbi Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components
    J Hellhammer
    Department of Psychobiology, University of Trier, D 54295 Trier, Germany
    Psychoneuroendocrinology 32:80-6. 2007
    ....
  43. ncbi Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis
    Stefan M Gold
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neuroimmunol 165:186-91. 2005
    ..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS...
  44. ncbi Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression
    M Hatzinger
    Psychiatric University Hospital, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    World J Biol Psychiatry 1:105-11. 2000
    ..In conclusion, research in neuroendocrinology provided new insights into the underlying pathophysiology of depression and, in consequence, may lead to the development of new therapeutic tools...
  45. ncbi Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
    ....
  46. ncbi The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone
    S Schroeder
    , , Bonn, Germany
    Crit Care Med 29:310-6. 2001
    ..In addition, the plasma cortisol response to a single CRH stimulation was impaired in nonsurvivors compared with survivors. Reduced responses to CRH stimulation may reflect a state of endocrinologic organ dysfunction in severe sepsis...
  47. ncbi When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Psychiatry 160:1554-65. 2003
    ....
  48. ncbi The HPA and immune axes in stress: the involvement of the serotonergic system
    B E Leonard
    Pharmacology Department, National University of Ireland, Galway, Ireland
    Eur Psychiatry 20:S302-6. 2005
    ....
  49. ncbi Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
    ..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
  50. ncbi The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
    Nicole M Cameron
    McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Montreal, Que, Canada H4H 1R3
    Neurosci Biobehav Rev 29:843-65. 2005
    ..Ultimately, we will need to contend with the reality that neural development, function and health are defined by social and economic influences...
  51. ncbi A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors
    Xavier Belda
    Institut de Neurociencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Horm Behav 54:654-61. 2008
    ..Long-term effects of IMO on the susceptibility to stress-induced endocrine and emotional disturbances may be relevant to the characterization of animal models of post-traumatic stress...
  52. ncbi Pituitary-adrenal response to acute and repeated mild restraint, forced swim and change in environment stress in arginine vasopressin receptor 1b knockout mice
    L Q Stewart
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, University of Bristol, Bristol, UK
    J Neuroendocrinol 20:597-605. 2008
    ..Furthermore, the normal corticosterone response to repeated exposure to change in environment stress also requires the Avpr1b to drive HPA axis responsiveness...
  53. ncbi Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  54. pmc Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
    B Czeh
    Division of Neurobiology, German Primate Center, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:12796-801. 2001
    ..These findings provide a cellular and neurochemical basis for evaluating antidepressant treatments with regard to possible reversal of structural changes in brain that have been reported in depressive disorders...
  55. ncbi Obesity and cortisol
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Goteborg, Sweden
    Nutrition 16:924-36. 2000
    ..The mechanism involved is not known, but available information suggests that programming of the hypothalamic-pituitary-adrenal axis may be responsible...
  56. ncbi Cytokines and major depression
    Olga J G Schiepers
    Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:201-17. 2005
    ....
  57. ncbi Importance of studying the contributions of early adverse experience to neurobiological findings in depression
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 29:641-8. 2004
    ....
  58. ncbi The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin
    Anthony P Coll
    Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 145:4721-7. 2004
    ..Although such glands are atrophic and hypofunctional, exposure to ACTH alone can restore their size, morphology, and corticosterone secretion...
  59. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
    ..We conclude that childhood family environments represent vital links for understanding mental and physical health across the life span...
  60. ncbi Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
    María Inés Forray
    Department of Pharmacy, Faculty of Chemistry, Catholic University of Chile, Santiago, Chile
    Brain Res Brain Res Rev 47:145-60. 2004
    ....
  61. ncbi Adrenal insufficiency in the critically ill: a new look at an old problem
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 122:1784-96. 2002
    ..HPA dysfunction is a common and underdiagnosed disorder in the critically ill. We review the risk factors, pathophysiology, diagnostic approach, and management of HPA dysfunction in the critically ill...
  62. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000
    ..The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress...
  63. ncbi Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function?
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 917:784-96. 2000
    ..These initial data, however, indicate that the genetic control of the autoimmune disease traits is highly complex...
  64. ncbi Prenatal stress and risk for psychopathology: specific effects or induction of general susceptibility?
    Anja C Huizink
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Utrecht, Netherlands
    Psychol Bull 130:115-42. 2004
    ..Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology...
  65. ncbi A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity
    Stefan Wüst
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Ann N Y Acad Sci 1032:52-62. 2004
    ....
  66. pmc The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors
    Stephen J Lolait
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology LINE, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    Endocrinology 148:849-56. 2007
    ..The data suggest that the Avpr1b is required for the normal pituitary and adrenal response to some acute stressful stimuli and is necessary only for a normal ACTH response during chronic stress...
  67. ncbi Salivary cortisol and dehydroepiandrosterone in relation to puberty and gender
    Clare Netherton
    Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Psychoneuroendocrinology 29:125-40. 2004
    ..Changes in hypothalamic-pituitary-adrenal (HPA) axis function that occur during puberty may have implications for immediate and long-term adolescent health...
  68. ncbi Depression, stress and the adrenal axis
    Carmine M Pariante
    Institute of Psychiatry, King s College London, London, UK
    J Neuroendocrinol 15:811-2. 2003
    ..Moreover, antidepressants directly regulate HPA axis function. These novel findings are reshaping our understanding of the causes and treatment of this disabling disorder...
  69. ncbi Neuroendocrine and immunocytochemical demonstrations of decreased hypothalamo-pituitary-adrenal axis responsiveness to restraint stress after long-term social isolation
    M M Sanchez
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Endocrinology 139:579-87. 1998
    ..This hypofunction was particularly evident after exposure to an acute stressor, suggesting a desensitization of this axis to stressful stimuli...
  70. ncbi The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse
    Mathias V Schmidt
    Gorlaeus Laboratories, Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Centre, Leiden University, P O Box 9502, The Netherlands
    Int J Dev Neurosci 21:125-32. 2003
    ..These results demonstrate for the first time the correlation between the postnatal endocrine development of the mouse and gene expression changes of central regulators of HPA axis function...
  71. ncbi Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level
    Susanne K Droste
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    Neuroendocrinology 86:26-37. 2007
    ..Evidence is accumulating that the regular performance of exercise is beneficial for stress coping. However, the hypothalamic-pituitary-adrenocortical (HPA) axis of voluntarily exercising rats has never been comprehensively investigated...
  72. ncbi Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposure
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Psychoneuroendocrinology 31:526-36. 2006
    ..This interaction was not seen in the basolateral amygdala. Together, these findings suggest that chronic high dose, but not low dose, cannabinoid administration may result in increased emotionality and sensitization of the stress axis...
  73. ncbi Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time
    O Marti
    Departament de Biologia Cellular, Fisiologia i Immunologia, Unitat de Fisiologia Animal, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Eur J Neurosci 13:129-36. 2001
    ....
  74. ncbi Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis
    Marieke Emonts
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital University Medical Center, Rotterdam, The Netherlands
    Clin Infect Dis 44:1321-8. 2007
    ....
  75. ncbi Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 33:721-30. 2008
    ..Furthermore, chronic nicotine SA selectively cross-sensitized the HPA response to a novel stressor. These observations suggest that nicotine may selectively increase the HPA response to stressors in human smokers...
  76. ncbi Involvement of the hypothalamic--pituitary--adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Arthritis Rheum 44:493-507. 2001
    ..This review reinforces the belief that combined therapeutic approaches on a neuroendocrine immune basis are of crucial importance in a pathogenetically oriented therapy of RA...
  77. ncbi Major depression and the stress system: a life span perspective
    S E Meyer
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Dev Psychopathol 13:565-80. 2001
    ..The authors highlight the importance of multidisciplinary, longitudinal studies in attempting to gain a deeper understanding of the complex developmental processes involved in the onset and course of depression...
  78. pmc Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Mol Cell Biol 20:9009-17. 2000
    ..Furthermore, they may explain differences in the susceptibility of humans to inflammatory diseases and stress, depending on individual prenatal and postnatal experiences known to influence the expression of the glucocorticoid receptor...
  79. ncbi Sleep and the hypothalamo-pituitary-adrenocortical system
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Sleep Med Rev 6:125-38. 2002
    ..Some data suggest a major effect of light on cortisol secretion. Sleeping is widely associated with blunting and awakenings are linked with increases of HPA hormones...
  80. ncbi The significance of glucocorticoid pulsatility
    Stafford L Lightman
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY
    Eur J Pharmacol 583:255-62. 2008
    ..This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor...
  81. ncbi Neurobiological and psychosocial processes associated with depressive and substance-related disorders in adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Curr Drug Abuse Rev 1:68-80. 2008
    ....
  82. ncbi Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  83. pmc Hypothalamic involvement in chronic migraine
    M F Peres
    Sao Paulo Headache Center, R Maestro Cardim, 887 01323 001, Sao Paulo SP, Brazil
    J Neurol Neurosurg Psychiatry 71:747-51. 2001
    ..The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion...
  84. ncbi Involvement of the glucocorticoid receptor in the pathogenesis of rheumatoid arthritis
    Gunther Neeck
    Kerckhoff Clinic and Foundation, Bad Nauheim, Germany
    Ann N Y Acad Sci 966:491-5. 2002
    ..These results seem to reflect a functional dysregulation of the HPA axis and may lead to a better understanding of the pathogenesis of RA...
  85. ncbi Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls
    Andreas H Böhmelt
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 67:288-94. 2005
    ..The aim of this study was to investigate alterations of pituitary-adrenal activity under both stimulated and unstimulated conditions in patients with functional gastrointestinal disorders...
  86. ncbi Combined stimulation of adrenocorticotropin and compound-S by single dose metyrapone test as an outpatient procedure to assess hypothalamic-pituitary-adrenal function
    K Berneis
    Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine, University Hospitals, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 87:5470-5. 2002
    ..Despite the relatively high cross-reactivity of CMP-S in the cortisol assay, the sum of CMP-S and cortisol levels with a cut-off value of 450 nmol/liter yields a better diagnostic accuracy compared with CMP-S alone...
  87. ncbi The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease
    Marina O'Kane
    Department of Dermatology, Adelaide and Meath Hospital, Dublin 24, Ireland
    Exp Dermatol 15:143-53. 2006
    ..This stress may be psychological or physical. CRH, produced locally or delivered by peripheral nerves, may mediate interactions between a cutaneous HPA axis-like system and the central HPA axis--the "brain-skin axis"...
  88. ncbi Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study
    J McBeth
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:360-71. 2007
    ..To test the hypothesis that abnormalities in the hypothalamic-pituitary-adrenal (HPA) stress-response system would act as an effect moderator between HPA function and the onset of chronic widespread pain (CWP)...
  89. ncbi The effects of child maltreatment on the hypothalamic-pituitary-adrenal axis
    Elizabeth Van Voorhees
    Virginia Polytechnic Institute and State University, USA
    Trauma Violence Abuse 5:333-52. 2004
    ....
  90. ncbi A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans
    Yongwimon Lenbury
    Department of Mathematics, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok 10400, Thailand
    Math Med Biol 22:15-33. 2005
    ....
  91. ncbi HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study
    Rianne Marsman
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Psychoneuroendocrinology 33:789-98. 2008
    ..It would be useful to consider how other risk factors such as life events and family and parenting factors as well as genetic risks affect the complex relationship between externalizing behavior problems and HPA-axis activity...
  92. ncbi Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis
    Angelika Buske-Kirschbaum
    Center for Psychobiological and Psychosomatic Research, University of Trier, 54286 Trier, Germany
    J Clin Endocrinol Metab 87:4245-51. 2002
    ....
  93. ncbi Dysregulation of the stress response in asthmatic children
    K N Priftis
    Department of Allergy Pneumonology, Penteli Children s Hospital, P Penteli, Greece
    Allergy 64:18-31. 2009
    ..Few patients may experience further deterioration of adrenal function, a phenomenon which may be genetically determined...
  94. ncbi Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity...
  95. ncbi Single nucleotide polymorphisms related to HPA axis reactivity
    Roel H DeRijk
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Neuroimmunomodulation 16:340-52. 2009
    ..We propose that these genetic variants which modulate HPA axis reactivity are part of the genetic makeup that determines individual stress responsivity and coping style, affecting vulnerability to disease...
  96. ncbi A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis
    David C Mohr
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94131, USA
    Brain Behav Immun 20:27-36. 2006
    ..These three hypotheses are not necessarily mutually exclusive. Data on psychosocial mediators and moderators are also briefly reviewed and future research directions are discussed...
  97. pmc Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation
    N Shanks
    Division of Medicine, University of Bristol, Bristol Royal Infirmary Labs, Marlborough Street, Bristol, BS2 8HW, United Kingdom
    Proc Natl Acad Sci U S A 97:5645-50. 2000
    ..These findings demonstrate a potent and long-term effect of neonatal exposure to inflammatory stimuli that can program major changes in the development of both neuroendocrine and immunological regulatory mechanisms...
  98. ncbi Subjective memory complaints in aging are associated with elevated cortisol levels
    Oliver T Wolf
    Institute for Experimental Psychology, University of Duesseldorf, Germany
    Neurobiol Aging 26:1357-63. 2005
    ..Differences in personality traits or in stress susceptibility might underlie the present findings. Future studies of memory complaints should take a comprehensive approach including relevant endocrine parameters...
  99. ncbi Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress
    A J Tilbrook
    Department of Physiology, Monash University, Victoria, Australia
    Front Neuroendocrinol 27:285-307. 2006
    ..The possible roles of inhibitory central inputs to CRH and AVP neurons and of oxytocin and prolactin in attenuating the HPA axis responses to stress are unknown...
  100. ncbi Low-dose dexamethasone suppression test in chronic fatigue syndrome and health
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychosom Med 64:311-8. 2002
    ..The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome...
  101. ncbi Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
    Nicolas Rohleder
    Department of Psychology, Institute of Experimental Psychology II, University of Dusseldorf, Dusseldorf, Germany
    Biol Psychiatry 55:745-51. 2004
    ..Alterations include various responses to HPA axis stimulation, different basal hormone levels, and changes in glucocorticoid receptor (GR) numbers on lymphocytes. The functional significance of these latter changes remains elusive...

Research Grants63

  1. Biobehavioral Characterization of Infant Rhesus Monkeys
    John P Capitanio; Fiscal Year: 2013
    ....
  2. Fetal and Neonatal Pituitary-Adrenal Function
    James C Rose; Fiscal Year: 2010
    ....
  3. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1993
    ..This RCDA award will give the candidate the financial support necessary to pursue her research interest as her sole focus in the next 5 years, and to develop her own strong, independent research program...
  4. Mechanisms of Emotional Stress Effects on Hypothalamus
    Paul Sawchenko; Fiscal Year: 2007
    ..A fuller basic understanding of circuits and mechanisms underlying these adaptations will promote more effective management of stress related disease. ..
  5. NEUROCHEMICAL & HORMONAL FACTORS IN STRESS
    ADRIAN DUNN; Fiscal Year: 1990
    ..A comparison of the activation of synthesis in DA and NE terminals during stress will also be made. Finally, the ability of benzodiazepines and of neurotensin to counteract or diminish the stress responses will be examined...
  6. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 1992
    ....
  7. DEVELOPMENTAL AND BEHAVIORAL NEUROENDOCRINOLOGY
    Seymour Levine; Fiscal Year: 1990
    ..Finally, we propose to establish a laboratory model of adolescence by examining behavioral and gonadal hormone changes that occur during puberty in the squirrel monkey...
  8. PSYCHOLOGICAL MODULATION OF STRESS IN AGING
    LINDA BRETT; Fiscal Year: 1980
    ..The indicant of pituitary-adrenal response in each of the proposed experiments will be plasma levels of corticosterone. ..
  9. PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMES
    Pathik Wadhwa; Fiscal Year: 2002
    ....
  10. DST and Suicide Prediction
    Elizabeth Young; Fiscal Year: 2003
    ....
  11. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ....
  12. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
    ..The results of these studies will provide data on whether the biology of these disorders support the nosological distinction between panic disorder, pure major depression and major depression with co-morbid panic disorder. ..
  13. Biology of Risk of PTSD in Holocaust Survivor Offspring
    Rachel Yehuda; Fiscal Year: 2006
    ..The subjects will be further subdivided so that there are 40 in each group with and without PTSD; half of each subgroup will have a current depressive disorder. Thus, we will recruit a total of 20 subjects in each of 12 subgroups. ..
  14. Relationship between Bio and Psych Correlates of PTSD
    Rachel Yehuda; Fiscal Year: 2005
    ..abstract_text> ..
  15. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2006
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  16. Genetics, Endocrinology and PTSD Risk in the Population
    Rachel Yehuda; Fiscal Year: 2006
    ..The development of models of prevention and treatment of PTSD can only occur following an understanding of individual risk factors and their interactions with event exposure. ..
  17. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2006
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  18. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2007
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  19. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2010
    ..abstract_text> ..
  20. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2008
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
  21. Psychobiology of PTSD: A Decade of Progress
    Rachel Yehuda; Fiscal Year: 2005
    ..We also expect the conference to be attractive to educated lay individuals such as consumers, family members, advocates, and members of the press who are interested in tracking the development of knowledge in this area. ..
  22. Developmental Psychobiology of Stress in Children
    Megan Gunnar; Fiscal Year: 2006
    ..abstract_text> ..
  23. Early Experience, Stress Neurobiology & Prevention Sci
    Megan Gunnar; Fiscal Year: 2005
    ....
  24. NeuroBehavioral Correlates of Early Deprivation
    Megan Gunnar; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  25. Risk for Depression Stress and Neuroendocrine Function
    AUDREY TYRKA; Fiscal Year: 2008
    ..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
  26. Psychobiological studies of stress in young children
    Megan Gunnar; Fiscal Year: 2005
    ..We argue that normative developmental research complements and provides basic data necessary for research and theory on developmental psychopathology. ..
  27. ADJUSTMENT OF INTERNATIONALLY ADOPTED CHILDREN
    Megan Gunnar; Fiscal Year: 2002
    ..This work will add significantly to our understanding of the health and behavioral sequelae of early adversity and th potential impact of early adversity on stress-sensitive limbic-hypothalamic processes. ..
  28. Lofexidine to Prevent Stress-Related Opiate Relapse
    Rajita Sinha; Fiscal Year: 2007
    ..abstract_text> ..
  29. Sex-Specific Pathways Linking Stress and Drug Abuse
    Rajita Sinha; Fiscal Year: 2008
    ..Such an understanding will have important implications for the development of gender-specific treatments for cocaine dependence that will ultimately improve the health of cocaine-addicted women and their families. ..
  30. Understanding Neurodevelopment in Macaques with Different Rearing Experiences
    Mar Sanchez; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Anatomical Plasticity and HPA Axis Dysfunction
    James Herman; Fiscal Year: 2009
    ..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
  32. Sex Differences in Hippocampal Synaptic Protein & mRNA
    Russell Romeo; Fiscal Year: 2005
    ..Finally, additional experiments will provide novel information on how exposure to steroid hormones during prenatal development sexually differentiates the ability of estrogen to affect hippocampal synapses. ..
  33. OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR
    Mar Sanchez; Fiscal Year: 2003
    ....
  34. PROGRAMMING GLUCOCORTICOID SECRETION DURING FETAL LIFE
    David Phillips; Fiscal Year: 2003
    ..g. obesity reduction). ..
  35. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  36. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  37. Glucocorticoid Receptor Mechanisms, Stress and Aging
    James Herman; Fiscal Year: 2006
    ..abstract_text> ..
  38. Cognitive Modulation of Human Neuroendocrine Stress Axis
    James Abelson; Fiscal Year: 2005
    ..Existing animal data will be used to identify factors within the cognitive intervention which likely account for its potency and dismantling studies will be done to examine the separable effects of these factors. ..
  39. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  40. PSYCHOPHYSIOLOGY OF ADAPTATION--CHILDREN IN HEAD START
    Clancy Blair; Fiscal Year: 2002
    ....
  41. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  42. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2005
    ..abstract_text> ..
  43. Behavioral effects of cardiac arrest in mice
    ANNE DEVRIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  45. BEHAVIORAL MEDICINE: CARDIOVASCULAR DISEASE RESEARCH
    William Lovallo; Fiscal Year: 2003
    ..U. medical campus. Training will utilize classroom, laboratory, and clinical facilities at several departments and hospitals on campus. ..
  46. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2005
    ..Our competing renewal will be used to identify specific changes in these neuroreceptor systems, providing avenues for new pharmacologic investigations in the treatment of cocaine dependence. ..
  47. STRESS AND THE NEUROBIOLOGY OF DRUG AND ALCOHOL DEPENDE
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..The primary goal of this Training Program is to provide students and young scientists with comprehensive guidance in stress and drug abuse research. ..
  48. Effects of social factors on cardiac arrest outcome
    ANNE DEVRIES; Fiscal Year: 2009
    ....
  49. Prenatal Programming of Infant Temperament
    Elysia Davis; Fiscal Year: 2008
    ..Prospective studies, such as this one, are needed to better understand processes that might underlie this association. [unreadable] [unreadable] [unreadable]..
  50. DETERMINANTS OF DRUG EFFECTS ON DRUG MAINTAINED BEHAVIOR
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ..abstract_text> ..
  51. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  52. BRAIN-PITUITARY-ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2007
    ..The information should be useful for therapeutic advice for overweight, stressed people, and possibly provide insights into mechanisms underlying different types of depressive and anxiety disorders [unreadable] [unreadable]..
  53. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2007
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  54. Individual differences in maternal behavior in the rat
    Michael Meaney; Fiscal Year: 2007
    ..abstract_text> ..
  55. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  56. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  57. Prediction of Psychosis in Schizotypal Adolescents
    Elaine Walker; Fiscal Year: 2006
    ..In the long-term, the research holds promise for yielding findings that have implications for our conceptualization of the prodromal course of schizophrenia and other psychoses, and for approaches to preventive intervention. ..
  58. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....