Genomes and Genes
Summary: A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other biogenic amines, and neuropeptides.
Publications294 found, 100 shown here
- A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseasesJorg H Stehle
Institute of Anatomy III Cellular and Molecular Anatomy, Goethe University Frankfurt, Frankfurt, Germany
J Pineal Res 51:17-43. 2011The human pineal gland is a neuroendocrine transducer that forms an integral part of the brain...
- Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmittersValerie Simonneaux
Laboratoire de Neurobiologie Rythmes, UMR 7518 CNRS ULP, 12, rue de l université, 67000 Strasbourg, France
Pharmacol Rev 55:325-95. 2003Melatonin, the major hormone produced by the pineal gland, displays characteristic daily and seasonal patterns of secretion...
- Arylalkylamine N-acetyltransferase: "the Timezyme"David C Klein
Section on Neuroendocrinology, Office of Scientific Director, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 282:4233-7. 2007Arylalkylamine N-acetyltransferase controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates...
- TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathwaySanseray da Silveira Cruz-Machado
Laboratory of Chronopharmacology, Department of Physiology, Institute of Biosciences, Universidade de Sao Paulo, Sao Paulo, Brasil
J Pineal Res 49:183-92. 2010Nuclear factor-kappa B (NFKB), a pivotal player in inflammatory responses, is constitutively expressed in the pineal gland. Corticosterone inhibits pineal NFKB leading to an enhancement of melatonin production, while tumor necrosis factor ..
- Bidirectional communication between the pineal gland and the immune systemKrystyna Skwarlo-Sonta
Department of Vertebrate Physiology, Faculty of Biology, Warsaw University, Poland
Can J Physiol Pharmacol 81:342-9. 2003The pineal gland is a vertebrate neuroendocrine organ converting environmental photoperiodic information into a biochemical message (melatonin) that subsequently regulates the activity of numerous target tissues after its release into the ..
- Otx5 regulates genes that show circadian expression in the zebrafish pineal complexJoshua T Gamse
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland, 21210 USA
Nat Genet 30:117-21. 2002..Our results indicate that Otx5 rather than Crx regulates genes that show circadian expression in the zebrafish pineal complex...
- Biology of mammalian photoperiodism and the critical role of the pineal gland and melatoninB Malpaux
UMR 6073 INRA CNRS Université François Rabelais, Physiologie de la Reproduction et des Comportements, Nouzilly, France
J Biol Rhythms 16:336-47. 2001In mammals, photoperiodic information is transformed into a melatonin secretory rhythm in the pineal gland (high levels at night, low levels during the day)...
- Light directs zebrafish period2 expression via conserved D and E boxesGad Vatine
Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
PLoS Biol 7:e1000223. 2009..These findings extend the general understanding of the mechanism whereby the clock is entrained by light and how the regulation of clock gene expression by light has evolved in vertebrates...
- Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timingPedro A C M Fernandes
Laboratory of Chronopharmacology, Departamento de Fisiologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
J Pineal Res 41:344-50. 2006..However, scant information on the feedback action of molecules present in the blood on the pineal gland during the time course of an inflammatory response is available...
- Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal glandRodrigo Antonio Peliciari Garcia
University of Sao Paulo, Institute of Biomedical Sciences, Department of Physiology and Biophysics, Av Prof Lineu Prestes 1524, 1st Floor, Room 118, Sao Paulo, SP, CEP 05508 900, Brazil
Life Sci 82:108-14. 2008The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase...
- Modulation of Aanat gene transcription in the rat pineal glandAnthony K Ho
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
J Neurochem 112:321-31. 2010The main function of the rat pineal gland is to transform the circadian rhythm generated in the suprachiasmatic nucleus into a rhythmic signal of circulating melatonin characterized by a large nocturnal increase that closely reflects the ..
- Evidence of immune system melatonin production by two pineal melatonin deficient mice, C57BL/6 and Swiss strainsAraceli Gómez-Corvera
Department of Medical Biochemistry and Molecular Biology, The School of Medicine, University of Seville, Seville, Spain
J Pineal Res 47:15-22. 2009..For the pineal gland, both the wild type and the mutant isoforms were present in all mice strains although in different proportions...
- Melatonin in immunity: comparative aspectsKrystyna Skwarlo-Sonta
Department of Vertebrate Physiology, Warsaw University, Warsaw, Poland
Neuro Endocrinol Lett 23:61-6. 2002b>Pineal gland, by the diurnal rhythm of synthesis and release of its principal hormone, melatonin (MEL), is involved in reciprocal relationships between neuroendocrine and immune systems, responsible for keeping internal homeostasis in ..
- Nocturnal melatonin concentration is correlated with illness severity in patients with septic diseaseBoris Perras
Intensive Care Med 32:624-5. 2006
- Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal glandErik Maronde
Institute of Anatomy III, Goethe University, Frankfurt Main, Germany
J Pineal Res 51:145-55. 2011Time of day is communicated to the body through rhythmic cues, including pineal gland melatonin synthesis, which is restricted to nighttime...
- Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesisS Ganguly
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 4480, USA
Proc Natl Acad Sci U S A 98:8083-8. 2001..Similar switches could play a role in cAMP signal transduction in other biological systems...
- Daily variation of constitutively activated nuclear factor kappa B (NFKB) in rat pineal glandErika Cecon
Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, University of Sao Paulo, CEP 05508 900, Sao Paulo, Brazil
Chronobiol Int 27:52-67. 2010In mammals, the production of melatonin by the pineal gland is mainly controlled by the suprachiasmatic nuclei (SCN), the master clock of the circadian system...
- Molecular analysis of avian circadian clock genesT Yoshimura
Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya, 464 8601, Japan
Brain Res Mol Brain Res 78:207-15. 2000..was expressed throughout the day, while qPer2 and qPer3 showed robust circadian oscillation in the eye and the pineal gland. All three genes were expressed in various tissues...
- Corticosterone modulates noradrenaline-induced melatonin synthesis through inhibition of nuclear factor kappa BZulma S Ferreira
Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de Sao Paulo, Sao Paulo, Brazil
J Pineal Res 38:182-8. 2005In chronically inflamed animals, adrenal hormones exert a positive control on the secretion of melatonin by the pineal gland. In this paper, the mechanism of corticosterone as a modulator of melatonin and N-acetylserotonin (NAS) was ..
- Pinealectomy and melatonin administration in rats: their effects on plasma leptin levels and relationship with zincA K Baltaci
Department of Physiology, Meram Medical School, Selcuk University, Konya, Turkey
Acta Biol Hung 58:335-43. 2007..In addition, long-term administration of melatonin to rats leads to an increase in both leptin and zinc concentrations...
- Early-stage retinal melatonin synthesis impairment in streptozotocin-induced diabetic wistar ratsDaniella do Carmo Buonfiglio
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
Invest Ophthalmol Vis Sci 52:7416-22. 2011..The purpose of the present work was to evaluate the diurnal profile of retinal melatonin content and the regulation of its synthesis in the retina of streptozotocin-induced diabetic rats...
- Locally synthesized angiotensin modulates pineal melatonin generationOvidiu Baltatu
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
J Neurochem 80:328-34. 2002..Our results demonstrate that a local pineal RAS exerts a tonic modulation of indole synthesis by influencing the activity of TPH via AT1-receptors...
- Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4)Jong So Kim
Section on Neuroendocrinology, Program on Developmental Endocrinology and Genetics, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell Endocrinol 314:128-35. 2010..Our studies indicate that Drd4 is the dominant dopamine receptor gene expressed in the pineal gland. The gene is expressed in pinealocytes at levels which are approximately 100-fold greater than in other tissues,..
- Circadian genomics of the chick pineal gland in vitroStephen P Karaganis
Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
BMC Genomics 9:206. 2008....
- Circadian clock system in the pineal glandYoshitaka Fukada
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo and JST, CREST, Japan
Mol Neurobiol 25:19-30. 2002The pineal gland is a neuroendocrine organ that functions as a central circadian oscillator in a variety of nonmammalian vertebrates...
- Microglia play a role in mediating the effects of cytokines on the structure and function of the rat pineal glandS Y Tsai
Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Stritch School of Medicine, Maywood, IL 60153, USA
Cell Tissue Res 303:423-31. 2001The role of the pineal gland in regulating immune function has been extensively investigated. However, there is little information about possible feedback mechanisms of immunological factors on pineal gland neuroendocrine functions...
- Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal glandSergio Gonzalez
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, University of Barcelona, Barcelona, Spain
PLoS Biol 10:e1001347. 2012The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and ..
- Diurnal variation in p42/44 mitogen-activated protein kinase in the rat pineal glandA K Ho
Department of Physiology, Faculty of Medicine, 7 26 Medical Sciences Building, University of Alberta, Edmonton, Alta, Canada T6G 2H7
Mol Cell Endocrinol 208:23-30. 2003..there was a diurnal difference in mitogen-activated protein kinase (p42/44(MAPK)) phosphorylation in the rat pineal gland. Under a lighting regimen with 12h of darkness, there was a two- to four-fold increase in phosphorylated levels ..
- Glutamate transporter-mediated glutamate secretion in the mammalian pineal glandMean Hwan Kim
Department of Physics, Pohang University of Science and Technology, Kyungbuk 790 784, Republic of Korea
J Neurosci 28:10852-63. 2008..we suggest that glutamate transporters mediate synchronized elevation of L-glutamate and thereby efficiently downregulate melatonin secretion via previously identified inhibitory metabotropic glutamate receptors in the pineal gland.
- The mammalian pineal gland: known facts, unknown facetsErik Maronde
Dr Senckenbergische Anatomie, Institute of Anatomy III, Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Trends Endocrinol Metab 18:142-9. 2007In the mammalian pineal gland, information on environmental lighting conditions that is neuronally encoded by the retina is converted into nocturnally elevated synthesis of the hormone melatonin...
- Functional development of the zebrafish pineal gland: light-induced expression of period2 is required for onset of the circadian clockL Ziv
Department of Zoology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
J Neuroendocrinol 17:314-20. 2005In zebrafish, the pineal gland is a photoreceptive organ that contains an intrinsic circadian oscillator and exhibits rhythmic arylalkylamine-N-acetyltransferase (zfaanat2) mRNA expression...
- Circadian rhythms in isolated brain regionsMichikazu Abe
National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA
J Neurosci 22:350-6. 2002..The phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle...
- Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockworkAdi Tovin
Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
PLoS Genet 8:e1003116. 2012..RNA sequencing (RNA-seq) and DNA microarrays to systematically identify clock-controlled genes in the zebrafish pineal gland. In addition to a comprehensive view of the expression pattern of known clock components within this master ..
- Genetic control of melatonin synthesis in the pineal gland of the mouseS Ebihara
Science 231:491-3. 1986..Synthesis of melatonin from serotonin in the pineal gland requires the enzymes N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT)...
- The immune-pineal axis: stress as a modulator of pineal gland functionRenato Couto-Moraes
Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de Sao Paulo, Sao Paulo, Brazil
Ann N Y Acad Sci 1153:193-202. 2009..light detected by the retina adjusts the central clock in the suprachiasmatic nuclei, which innervate the pineal gland through a polysynaptic pathway...
- Pineal gland (melatonin) affects the parturition time, but not luteal function and fetal growth, in pregnant ratsHisako Takayama
Reproductive, Pediatric and Infectious Science, Perinatal Care Center, Yamaguchi University School of Medicine, 1 1 1, Minami Kogushi, Ube 755 8505 Japan
Endocr J 50:37-43. 2003The purpose of the present study was to investigate the role of pineal gland (melatonin) on parturition time, luteal function, and fetal growth in pregnant rats...
- The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complexR Baler
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:6979-85. 1997..3.1.87) controls the rhythm in melatonin synthesis in the pineal gland. In some mammals, including the rat, the high nocturnal level of AA-NAT activity is preceded by an ..
- Cloning and expression of arylalkylamine N-acetyltranferase-2 during early development and metamorphosis in the sole Solea senegalensisEsther Isorna
Departamento de Biologia, Facultad de Ciencias del Mar y Ambientales, Universidad de Cadiz, E 11510, Puerto Real, Espana, Spain
Gen Comp Endocrinol 161:97-102. 2009..These studies allowed us to demonstrate a specific signal in the pineal gland of sole larvae from 2 days post-fertilization (dpf), which was evident until post-metamorphosis...
- Moonlight affects nocturnal Period2 transcript levels in the pineal gland of the reef fish Siganus guttatusNozomi Sugama
Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus, Motobu, Okinawa, Japan
J Pineal Res 45:133-41. 2008..in rabbitfish Per2 (rfPer2) expression as well as the effect of light and moonlight on its expression in the pineal gland. The partially-cloned rfPer2 cDNA (2933 bp) was highly homologous (72%) to zebrafish Per2...
- Novel functions for Period 3 and Exo-rhodopsin in rhythmic transcription and melatonin biosynthesis within the zebrafish pineal organLain X Pierce
Department of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Brain Res 1223:11-24. 2008..This work identifies novel roles for Exorh and Per3, and gives insight into potential interactions between the sensory and circadian systems within the pineal...
- Pineal projections in the zebrafish (Danio rerio): overlap with retinal and cerebellar projectionsJ Yanez
Department of Cell and Molecular Biology, Faculty of Sciences, University of A Coruna, Campus da Zapateira, E 15008 A Coruña, Spain
Neuroscience 164:1712-20. 2009....
- Structural and functional evolution of the pineal melatonin system in vertebratesJack Falcon
Universite Pierre et Marie Curie PARIS6, Laboratoire Arago, Banyuls sur Mer, France
Ann N Y Acad Sci 1163:101-11. 2009..This review summarizes anatomical, structural, and molecular aspects of the evolution of the melatonin-producing system in vertebrates...
- The immune-pineal axis: a shuttle between endocrine and paracrine melatonin sourcesRegina P Markus
Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, University of Sao Paulo, Sao Paulo, Brasil
Neuroimmunomodulation 14:126-33. 2007..In the present review, we put together recent data that show that the pineal gland is a player in bidirectional control of the inflammatory response...
- Circadian clock genes and photoperiodism: Comprehensive analysis of clock gene expression in the mediobasal hypothalamus, the suprachiasmatic nucleus, and the pineal gland of Japanese Quail under various light schedulesShinobu Yasuo
Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
Endocrinology 144:3742-8. 2003..we show expression patterns of circadian clock genes in the MBH, putative suprachiasmatic nucleus (SCN), and pineal gland, which constitute the circadian pacemaker under various light schedules...
- Expression of pineal ultraviolet- and green-like opsins in the pineal organ and retina of teleostsJ Forsell
Department of Zoology, University of Lund, Sweden
J Exp Biol 204:2517-25. 2001..In the other teleosts studied, although both pineal and retinal photoreceptors seem to utilise a green-like opsin from the larval stage, ultraviolet photoreception appears to be restricted to the retina...
- Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal glandJ H Stehle
CNRS URA 1332, Universite Louis Pasteur, Strasbourg, France
Nature 365:314-20. 1993..Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway...
- Parapinopsin, a novel catfish opsin localized to the parapineal organ, defines a new gene familyS Blackshaw
Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, Maryland 21205, USA
J Neurosci 17:8083-92. 1997..These data imply that phototransduction in these sites of extraretinal photoreception must be mediated by novel opsins...
- Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal glandP H Roseboom
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892 4480
Endocrinology 137:3033-45. 1996..We have discovered that expression of the AA-NAT gene in the rat pineal gland is essentially turned off during the day and turned on at night, resulting in a more than 150-fold rhythm...
- Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamilyM Becker-Andre
Glaxo Institute for Molecular Biology, Plan les Ouates, Switzerland
J Biol Chem 269:28531-4. 1994..We found RZR beta expression in the rat brain nearly coincident with binding sites for the pineal gland hormone melatonin (5-methoxy-N-acetyltryptamine)...
- The effects of pineal gland transplantation on the production of spinal deformity and serum melatonin level following pinealectomy in the chickenMehmet Turgut
Department of Neurosurgery, Adnan Menderes University School of Medicine, Aydin, Turkey
Eur Spine J 12:487-94. 2003..Thirty-six chickens (2 days of age) were divided into three equal groups. While the removal of the pineal gland was performed in groups B and C, a pineal body autograft was surgically implanted into the body wall ..
- Effect of streptozotocin-induced diabetes on daily expression of per2 and dbp in the heart and liver and melatonin rhythm in the pineal gland of Wistar ratIveta Herichova
Department of Animal Physiology and Ethology, Comenius University Bratislava, Mlynska dolina, Bratislava, Slovak Republic
Mol Cell Biochem 270:223-9. 2005..Changes in per2 and dbp expression in the heart and liver imply alterations in input pathway or peripheral oscillators with possible consequences on function of analysed organs...
- Complex circadian regulation of pineal melatonin and wheel-running in Syrian hamstersJ A Elliott
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950
J Comp Physiol A 174:469-84. 1994..This two-oscillator control of melatonin peak width is integral to the circadian mechanism of hamster photoperiodic time measurement...
- Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patientsRichard Mahlberg
Department of Physiology, Charite Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, D 14195 Berlin, Germany
Sleep Med 10:439-45. 2009..The aim of our study was, therefore, to determine the relationship between the degree of pineal calcification (DOC) and a range of sleep parameters measured objectively using polysomnography (PSG)...
- Photoperiodic information acquired and stored in vivo is retained in vitro by a circadian oscillator, the avian pineal glandR Brandstatter
Research Centre for Ornithology of the Max Planck Society, Von der Tann Strasse 7, D 82346 Erling Andechs, Germany
Proc Natl Acad Sci U S A 97:12324-8. 2000..during in vivo synchronization can be maintained as an internal representation of time within the isolated pineal gland. Hence, the pineal gland, as one of the most significant components of the songbird circadian pacemaker, not ..
- A novel rod-like opsin isolated from the extra-retinal photoreceptors of teleost fishA R Philp
Department of Biology, Sir Alexander Fleming Building, Imperial College of Science, Technology and Medicine, London, UK
FEBS Lett 468:181-8. 2000..We speculate that the differences between retinal rod-opsins and ERrod-like opsins have arisen from their differing photosensory roles and/or genetic drift after the gene duplication event in the Triassic...
- Effects of the blockade of high voltage-activated calcium channels on in vitro pineal melatonin synthesisSolange C Afeche
Laboratory of Pharmacology, Butantan Institute, Av Vital Brazil, 1500 Sao Paulo, SP 05503 900, Brazil
Cell Biochem Funct 24:499-505. 2006The presence of high voltage-activated calcium channels in the rat pineal gland is well known. However, their role in pineal metabolism is not completely understood and is even controversial...
- Global daily dynamics of the pineal transcriptomeDiego M Bustos
Instituto Tecnológico de Chascomús Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, Camino Circunvalación Laguna km 6 cc164, B7130IWA, Chascomús, Argentina
Cell Tissue Res 344:1-11. 2011Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases...
- Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in miceC Lopes
Departamento de Fisiologia, , , Brasil
Inflamm Res 50:6-11. 2001..gland influence on diurnal rhythm of chronic inflammation induced by BCG in mice and its interaction with the pineal gland. METHODS: C57Bl/6 mice were injected with BCG in the footpad and maintained in a 12/12 h light-dark cycle...
- Melatonin: fifty years of scientific journey from the discovery in bovine pineal gland to delineation of functions in humanIndrajit Chowdhury
Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, USA
Indian J Biochem Biophys 45:289-304. 2008Melatonin (N-acetyl-5-methoxytryptamine) was first purified and characterized from the bovine pineal gland extract by Aron Lerner and co-workers in 1958...
- Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCRDavid Sugden
Centre for Reproduction, Endocrinology and Diabetes, School of Biomedical Sciences, Kings College London, London Bridge, London SE1 1UL, UK
J Neurochem 86:1308-11. 2003..As serotonin (5-HT) has an important role as a precursor of the nocturnal synthesis of the pineal gland hormone, melatonin, it was of interest to determine the relative expression of TPH1 and 2 mRNA in the rat ..
- The anatomy and innervation of the mammalian pineal glandMorten Møller
Institute of Medical Anatomy, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Cell Tissue Res 309:139-50. 2002The parenchymal cells of the mammalian pineal gland are the hormone-producing pinealocytes and the interstitial cells. In addition, perivascular phagocytes are present...
- Localization of circadian clock protein BMAL1 in the photoperiodic signal transduction machinery in Japanese quailKeisuke Ikegami
Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
J Comp Neurol 517:397-404. 2009..Among vertebrates, birds have multiple circadian pacemakers in the eye, the pineal gland, and the suprachiasmatic nucleus (SCN), and have highly sophisticated photoperiodic mechanisms...
- Crx broadly modulates the pineal transcriptomeLouise Rovsing
Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
J Neurochem 119:262-74. 2011..factor expressed selectively in retinal photoreceptors and pinealocytes, the major cell type of the pineal gland. In this study, the influence of Crx on the mammalian pineal gland was studied by light and electron microscopy ..
- Fusaric acid in Fusarium moniliforme cultures, corn, and feeds toxic to livestock and the neurochemical effects in the brain and pineal gland of ratsJ K Porter
Toxicology and Mycotoxin Research Unit, USDA ARS, Richard B Russell Agricultural Research Center, Athens, GA 30605 5677, USA
Nat Toxins 3:91-100. 1995..43 to 12.39 micrograms/g sample. Also, fusaric acid was tested for its neurochemical effects in the brain and pineal gland of rats...
- Photoreception and circadian clock system of the chicken pineal glandT Okano
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Microsc Res Tech 53:72-80. 2001..Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained...
- Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal glandF Cote
Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, CNRS, UMR 7091, Batiment CERVI, Hopital de la Pitie Salpetriere, 83 Boulevard de l hopital, 75013 Paris, France
J Neurochem 81:673-85. 2002..In the pineal gland, transcription of the gene is activated in response to an intracellular circadian increase of the cAMP ..
- Seasonality of pineal gland activity and immune functions in chickensPaweł Majewski
Department of Vertebrate Physiology, Faculty of Biology, Warsaw University, Warsaw, Poland
J Pineal Res 39:66-72. 2005..These two aspects of the immune response were correlated with the diurnal rhythm of pineal gland function, measured by the activity of N-acetyltransferase (NAT), a key enzyme in melatonin biosynthesis...
- The role of pineal gland in breast cancer developmentVladimir N Anisimov
Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, 197758, St Petersburg, Russia
Crit Rev Oncol Hematol 46:221-34. 2003The role of the modulation of the pineal gland function in development of breast cancer is discussed in this review...
- Computed tomography of the human pineal gland for study of the sleep-wake rhythm: reproducibility of a semi-quantitative approachS A Schmitz
Department of Radiology and Nuclear Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Acta Radiol 47:865-71. 2006....
- Retinopathy and attenuated circadian entrainment in Crx-deficient miceT Furukawa
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 23:466-70. 1999..homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland. Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of ..
- Nocturnal activation of aurora C in rat pineal gland: its role in the norepinephrine-induced phosphorylation of histone H3 and gene expressionD M Price
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Endocrinology 150:2334-41. 2009..Here we report the nocturnal phosphorylation of a Ser10 histone H3 kinase, Aurora C, in the rat pineal gland. The time profile of this phosphorylation parallels the increase in the level of phospho-Ser10 histone H3...
- Establishment and persistence of photoperiodic memory in hamstersB J Prendergast
Department of Psychology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 97:5586-91. 2000..These findings indicate that hamsters are influenced only by relatively recent day lengths and melatonin signals and ignore earlier ones that might cause them to misinterpret the salience of current day lengths...
- Pineal volume and circadian melatonin profile in healthy volunteers: an interdisciplinary approachIngo Nolte
Department of Neuroradiology, Medical Faculty Mannheim of the University of Heidelberg, Germany
J Magn Reson Imaging 30:499-505. 2009..To correlate pineal parenchyma volume (PP) to circadian melatonin profiles and to determine the 24-hour melatonin per volume of pineal tissue (MLPV). Furthermore, we compared melatonin profiles of cystic and solid glands...
- Rod outer segment membrane guanylate cyclase type 1-linked stimulatory and inhibitory calcium signaling systems in the pineal gland: biochemical, molecular, and immunohistochemical evidenceV Venkataraman
The Unit of Regulatory and Molecular Biology, Departments of Cell Biology and Ophthalmology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
Biochemistry 39:6042-52. 2000..receptor (alpha(2D/A)-AR) linked membrane guanylate cyclase signal transduction system in the pineal gland. This system operates via a Ca(2+)-driven rod outer segment membrane guanylate cyclase (ROS-GC)...
- ROS-GC subfamily membrane guanylate cyclase-linked transduction systems: taste, pineal gland and hippocampusRameshwar K Sharma
Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA 19027, USA
Mol Cell Biochem 334:199-206. 2010....
- Probing pineal-specific gene expression with transgenic zebrafishDaisuke Kojima
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
Photochem Photobiol 84:1011-5. 2008The pineal gland of zebrafish (Danio rerio) contains light-sensitive photoreceptor cells and plays an important role in the neuroendocrine system...
- Restricted feeding restores rhythmicity in the pineal gland of arrhythmic suprachiasmatic-lesioned ratsCeline A Feillet
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, Centre National de la Recherche Scientifique, University Louis Pasteur, Strasbourg, France
Eur J Neurosci 28:2451-8. 2008In mammals, the rhythmic synthesis of melatonin by the pineal gland is tightly controlled by the master clock located in the suprachiasmatic nuclei (SCN)...
- β-arrestin functionally regulates the non-bleaching pigment parapinopsin in lamprey pinealEmi Kawano-Yamashita
Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, Japan
PLoS ONE 6:e16402. 2011..Such changes would have followed the evolution of vertebrate visual pigments, which generate unstable photoproducts that independently decay by chromophore dissociation...
- Insulin temporal sensitivity and its signaling pathway in the rat pineal glandRodrigo A Peliciari-Garcia
University of Sao Paulo, Institute of Biomedical Sciences I, Department of Physiology and Biophysics, Sao Paulo, SP, Brazil
Life Sci 87:169-74. 2010..A second question raised was whether windows of sensitivity to insulin exist in the pineal gland due to insulin rhythmic secretion pattern.
- Structural organization of the human S-antigen gene. cDNA, amino acid, intron, exon, promoter, in vitro transcription, retina, and pineal glandK Yamaki
Molecular Biology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 265:20757-62. 1990..Our results indicate that the sequence of S-Ag promoter differs from other known promoters and may, perhaps, be specific for photoreceptor rod cells and pinealocytes...
- The pineal gland and anxiogenic-like action of fluoxetine in miceTolga Uz
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
Neuroreport 15:691-4. 2004..Behavioral responses to psychoactive drugs can be modified by the pineal gland. We assessed the actions of fluoxetine in the EPM in melatonin-proficient C3H mice, melatonin-deficient C57BL6 ..
- Retinal illumination phase shifts the circadian rhythm of serotonin N-acetyltransferase activity in the chicken pineal glandJolanta B Zawilska
Department of Pharmacology, Medical University of Łódź, Łódź, 90 151, Poland
Neurosci Lett 360:153-6. 2004The pineal gland of birds, in contrast to its mammalian counterpart, is a directly photosensitive organ...
- Opsin photoisomerases in the chick retina and pineal gland: characterization, localization, and circadian regulationMichael J Bailey
Center for Biological Clocks Research, Texas A and M University, College Station, TX 77843, USA
Invest Ophthalmol Vis Sci 45:769-75. 2004The chick retina and pineal gland exhibit circadian oscillations in biochemical and physiological processes in vivo and in vitro, which entrain to 24-hour light-dark cycles...
- Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal glandMarie Laure Garidou
Neurobiologie des Rythmes, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7518, Universite Louis Pasteur, 67000 Strasbourg, France
Am J Physiol Regul Integr Comp Physiol 284:R1043-52. 2003..The possibility that the variation in pineal metabolism depends on a seasonal change in the suprachiasmatic nuclei clock circadian activity that is transmitted by norepinephrine is discussed...
- The role of PACAP in the control of circadian expression of clock genes in the chicken pineal glandAndras D Nagy
Department of Anatomy, Medical School, University of Pecs, H 7624 Pecs, Szigeti ut 12, Hungary
Peptides 28:1767-74. 2007Several features of the molecular circadian oscillator of the chicken pineal gland show homology with those in the mammalian SCN...
- Temporal-spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissuesNelson W Chong
Division of Cardiology, Department of Medicine, Glenfield General Hospital, Clinical Sciences Wing, University of Leicester, Leicester LE3 9QP, UK
J Neurochem 85:851-60. 2003..In two tissues which contain endogenous clocks--the pineal gland and retina--circadian fluctuations of both cBmal1 and cMOP4 mRNAs were observed to be synchronous; highest ..
- Germinoma of the pineal glandS C Mohanty
Neurol India 51:286-7. 2003
- Hypothalamic circadian organization in birds. II. Clock gene expressionUte Abraham
Max Planck Research Centre for Ornithology, Andechs, Germany
Chronobiol Int 20:657-69. 2003..indicating that rhythmic pPer2 transcription in the SCN and LHN of the house sparrow are not driven by the pineal gland. Rather, they reflect the activity of autonomous hypothalamic circadian oscillators...
- Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouseDaiichiro Nakahara
Department of Psychology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
Proc Natl Acad Sci U S A 100:9584-9. 2003..long-term monitoring of melatonin secretion by implanting a transverse microdialysis probe in or near the pineal gland in a freely moving mouse...
- Management of pineal region tumorsJaishri O Blakeley
Brain Cancer Program, Johns Hopkins University, Cancer Research Building 2, 1550 Orleans Street, Suite 1M16, Baltimore, MD 21231, USA
Curr Treat Options Oncol 7:505-16. 2006..Patients with tectal gliomas may undergo excision with or without postoperative radiation; however, they also may be observed with vigilant follow-up alone...
- Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki ratsAndreas Gunter Bach
Institute of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstrasse 52, 06097 Halle Saale, Germany
Endocrinology 151:2483-93. 2010..expressed than in Wistar rats, 2) the formation of 5-hydroxytryptophan is crucially impaired, and 3) the pineal gland protein content is significantly reduced compared with that in Wistar rats...
- Microsurgical management of pineal region lesions: personal experience with 119 patientsJuha Hernesniemi
Department of Neurosurgery, Helsinki University Central Hospital, 00260 Helsinki, Finland
Surg Neurol 70:576-83. 2008..We present the surgical approaches and techniques in a consecutive series of 119 patients treated by the senior author (J.H.) between 1980 and 2007 at 2 different neurosurgical university centers in Kuopio and Helsinki, Finland...
- Pineal organs of deep-sea fish: photopigments and structureJames K Bowmaker
Division of Visual Science, Institute of Ophthalmology, University College London, EC1V 9EL, UK
J Exp Biol 207:2379-87. 2004..In one species of hatchet fish, Argyropelecus affinis, two spectral classes of pinealocyte were identified, both spectrally distinct from the retinal rod photopigment...
- Melatonin synthesis in the human pineal gland: advantages, implications, and difficultiesKatrin Ackermann
Dr Senckenbergische Anatomie, Institute of Anatomy III, University Frankfurt, Frankfurt Main, Germany
Chronobiol Int 23:369-79. 2006..The best characterized function of the pineal gland is the nocturnally elevated synthesis of the hormone melatonin, which provides the body with the signal of the ..
- The avian pineal glandValer J Csernus
Department of Anatomy, University of Pecs, Medical School and Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, Pecs, Hungary
Chronobiol Int 23:329-39. 2006The pineal gland plays a key role in the control of the daily and seasonal rhythms in most vertebrate species...
- The circadian system of ruin lizards: a seasonally changing neuroendocrine loop?Augusto Foá
Dipartimento di Biologia e Centro di Neuroscienze, Universita degli Studi di Ferrara, Ferrara, Italy
Chronobiol Int 23:317-27. 2006..To test whether seasonal photoperiodic changes are decoded autonomously by the pineal gland, pineals explanted in summer were cultured in vitro and exposed to changes between winter and summer ..
- Spectral sensitivity of melatonin suppression in the zebrafish pineal glandLimor Ziv
Department of Zoology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Exp Eye Res 84:92-9. 2007The pineal gland of the zebrafish (Danio rerio) is a clock-containing photoreceptive organ...
- Histone H3 phosphorylation in the rat pineal gland: adrenergic regulation and diurnal variationC L Chik
Department of Physiology, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
Endocrinology 148:1465-72. 2007In this study, we investigated phosphorylation of Ser10 in histone H3 by norepinephrine (NE) in the rat pineal gland. In whole-animal studies, we demonstrated a marked increase in histone H3 phosphorylation in the rat pineal gland during ..
- Immunohistochemical characterization of a parapinopsin-containing photoreceptor cell involved in the ultraviolet/green discrimination in the pineal organ of the river lamprey Lethenteron japonicumEmi Kawano-Yamashita
Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
J Exp Biol 210:3821-9. 2007....
- Melatonin synthesis and melatonin-membrane receptor (MT1) expression during rat thymus development: role of the pineal glandSilvia Jimenez-Jorge
Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
J Pineal Res 39:77-83. 2005To gain insight into the relationship between thymus and pineal gland during rat development, the melatonin content as well as the activity and expression of the two key enzymes for melatonin biosynthesis, i.e...
- Expression of protein gene product 9.5, tyrosine hydroxylase and serotonin in the pineal gland of rats with streptozotocin-induced diabetesMang Hung Tsai
Department of Anatomy, College of Medicine, China Medical University, Taichung 404, Taiwan
Neurosci Res 60:233-43. 2008..This study was undertaken to examine the structure, innervation and functional activity of the pineal gland in streptozotocin (STZ)-induced diabetes in rats by immunohistochemistry, Western blotting and image analysis...
- LIGHT DURING DARKNESS AND BREAST CANCER PROGRESSIONDavid Blask; Fiscal Year: 2004..The pineal gland hormone melatonin, which inhibits experimental human breast cancer growth, is produced during darkness; light ..
- The Role of Circadian Periodicity in Human Cardiovascular Disease and DiabetesJohn P Forman; Fiscal Year: 2013..Melatonin is a hormone secreted by the pineal gland (under the control of the suprachiasmatic nucleus) and entrained to the dark phase of a light-dark cycle...
- Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep DisordersMargarita L Dubocovich; Fiscal Year: 2010..Melatonin, a neurohormone secreted in a circadian fashion by the pineal gland, promotes sleep and regulates circadian rhythmicity by activating two membrane-bound G-protein coupled ..
- Role of exogenous melatonin in skin biologyAndrzej T Slominski; Fiscal Year: 2013DESCRIPTION (provided by applicant): It was assumed that in vertebrates melatonin is only produced in the pineal gland and retina...
- Mechanisms of Functional Recovery After Partial Nerve InjuryMichael M Wang; Fiscal Year: 2012..Normally, the bilateral superior cervical ganglia (SCG) both innervate the pineal gland to stimulate nightly melatonin synthesis...
- Electric Studies of Excitation, Secretion &ContractionBertil Hille; Fiscal Year: 2013DESCRIPTION (provided by applicant): The pineal gland is an endocrine organ in the brain that is primarily regulated by noradrenaline released by the sympathetic nervous system...
- Circadian rhythms and melatonin signaling in the aging gastrointestinal systemVincent M Cassone; Fiscal Year: 2013..changes in intestinal function during aging is the circadian secretion of the hormone melatonin by the pineal gland and by intestinal tissues themselves...
- Regulation of Bile Duct Growth in Bile Duct Ligated RatsSHANNON STROUD GLASER; Fiscal Year: 2013..from cholangiocytes), paracrine (by administration of melatonin or anti-melatonin antibody) and central (from pineal gland) melatonin synthesis (regulated by the enzyme AANAT expressed in the liver mainly by cholangiocytes) ..
- 2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, slVincent M Cassone; Fiscal Year: 2011..2012 GRC will be to increase our understanding of the molecular networks and biochemical pathways linking the pineal gland and its hormone melatonin with the circadian clock timing system, sleep/wake processing and metabolism...
- Characterization of diverse melanopsin-expressing cells in zebrafishVANESSA MATOSCRUZ; Fiscal Year: 2011..mammalian gene, but also is expressed in a small number of cells at the 3ase ofthe phototoreceptive organ, the pineal gland. The goal of this study is to identify and explore the unctions of opn4-expressing cells in the retina...
- 2010 Pineal Cell Biology Gordon Research ConferenceDAVID RAYMOND WEAVER; Fiscal Year: 2010..on Pineal Cell Biology are to increase our understanding of the molecular and cellular function of the pineal gland, of how the rhythmic synthesis and release of the pineal hormone melatonin contributes to vertebrate physiology,..
- Sleep Length and Circadian Regulation in HumansHELEN JULIA BURGESS; Fiscal Year: 2012..timing of the human circadian clock by measuring salivary melatonin, a neuroendocrine hormone released from the pineal gland, and collecting measures of sleep via actigraphy, and sleepiness, mood, gastrointestinal distress and cognitive ..
- COORDINATION OF CIRCADIAN PHYSIOLOGY OF DIVERSE SPECIESDeborah Bell Pedersen; Fiscal Year: 2010..be studied in 4 instructive model systems: the cyanobacterium Synechococcus, the fungus Neurospora, the chick pineal gland, and the rodent suprachiasmatic nucleus (SCN)...
- Targeting Placental Pathophysiology in IUGR and PreeclampsiaSeth Guller; Fiscal Year: 2010..Importantly, we observed that treatment with glucocorticoid (GC), and the pineal gland peptide melatonin (MT), suppressed IL-!3 effects on cytokine expression in FIBs...
- Efficacy of melatonin treatment in a phase advance model of insomniaJeanne F Duffy; Fiscal Year: 2013Melatonin is a hormone produced by the pineal gland at night. The timing of its release is controlled by the circadian timing system...
- Melatonin: pacemaker for nocturnal periodicity of microfilarial parasitesJEFFERSON ARCHER VAUGHAN; Fiscal Year: 2012..regulates mf periodicity is the bioactive amine, melatonin, which is secreted into the blood stream from the pineal gland at a regular, circadian periodicity...
- PINEAL FUNCTION IN CHILDHOOD AND ADOLESCENCEAnita Cavallo; Fiscal Year: 1990In spite of numerous studies, the role of the pineal gland in human puberty remains unsettled...
- MOLECULAR NEUROBIOLOGY OF THE CIRCADIAN CLOCKVincent Cassone; Fiscal Year: 2000..These components, whose relative roles vary among species, include the suprachiasmatic nucleus (SCN), the pineal gland and eyes, which influence circadian rhythms via the hormone melatonin...
- ENVIRONMENTAL CONTROL OF SEASONAL WEIGHT CYCLESGeorge Wade; Fiscal Year: 1992..The effects of photoperiod on body weight are mediated by the pineal gland and its hormone, melatonin, Pinealectomized (PINX) hamsters typically do not respond to changes in photoperiod, ..
- RHODOPSIN KINASE: REGULATION, FUNCTION AND STRUCTUREKrzysztof Palczewski; Fiscal Year: 1993..Rhodopsin kinase activity has been detected in the pineal gland and in retinoblastoma cells...
- S-ANTIGEN--STRUCTURE/FUNCTION RELATIONSHIPS IN UVEITISLarry Donoso; Fiscal Year: 1991..These MAbs have been useful in our studies concerning S-antigen in the developing retina, pineal gland and in tumors arising from these tissues. The amino acid sequence of bovine S-antigen has now been determined...
- DOSE-RESPONSE CURVE FOR MELATONIN IN THE ELDERLYAlfred Lewy; Fiscal Year: 2000DESCRIPTION: (adapted from investigator's abstract): Melatonin is a hormone produced by the pineal gland only during nighttime darkness...
- PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONINManuchair Ebadi; Fiscal Year: 2002..brain, the third specific aim of this proposal are to determine the nature of dopamine transporters in bovine pineal gland by using [3H]GBB-12935 and autoradiography and to delineate the expression of D1 and D2 dopamine receptor mRNA ..
- SLEEP IN OLDER WOMEN--EFFECTS OF ESTROGENKAREN MOE; Fiscal Year: 2001..g., the suprachiasmatic nucleus, the hypothalamic pre-optic area, and the pineal gland)...
- EFFECT OF MELATONIN ON HUMAN CIRCADIAN RHYTHMSRobert Sack; Fiscal Year: 1993Melatonin is a hormone produced by the pineal gland at night that may be involved in the natural regulation of circadian rhythms...
- REPRODUCTION--PINEAL GRAFTS, LH, FSH, AND PROLACTINMARCIA WELSH; Fiscal Year: 1992..This proposal addresses the question of how the pineal gland interacts with the CSF in both the intact system and in pineal grafts placed into the third ventricle...
- PINEAL GAP JUNCTION--CHARACTERIZATION AND REGULATIONJUAN SAEZ; Fiscal Year: 1992..will control for its effect on junctions formed by connexin 26, which could be relevant to function of the pineal gland as well as to regulation of gap junctions in general...
- Melatonin Randomized Trial in Insomnia in the ElderlyNalaka Gooneratne; Fiscal Year: 2006..A growing body of work has suggested that melatonin, a neurohormone produced by the pineal gland and regulated by the suprachiasmatic nucleus, the primary circadian pacemaker, may play a role in mediating ..
- MANAGEMENT OF SLEEP-ACTIVITY DISRUPTION IN ALZHEIMERSGlenna Dowling; Fiscal Year: 2001..properly time bright light exposure and exogenous administration of melatonin (a neurohormone produced by the pineal gland during darkness) are needed...
- Viral receptors of the visual nervous systemMark Greene; Fiscal Year: 2007..the developing optic nervous system and its special role in MuIler and ganglion cells of the retina and in the pineal gland using the high affinity MAb species...
- CHRONOBIOLOGY AND GASTROINTESTINAL ENDOCRINOLOGYPHILIP RAYFORD; Fiscal Year: 1993..The suprachiasmatic nucleus, the pineal gland and melatonin, adrenal glands and their secretions; and, the gonads and gonadal steroids...
- ENVIRONMENTAL INFLUENCES ON SYNAPTIC PHARMACOLOGYRICHARD ZIGMOND; Fiscal Year: 1993..We have studied this problem in the pineal gland using the known dependence of the activity of the enzyme serotonin N-acetyltransferase (NAT) on sympathetic ..
- NEUROENDOCRINE MECHANISMS IN SEASONAL REPRODUCTIONBRYANT BENSON; Fiscal Year: 1990..This event is mediated by the pineal gland since its presence is required for SP to produce an antigonadotropic effect...
- Melatonin and Aging in Non-human PrimatesIrina Zhdanova; Fiscal Year: 2006..of melatonin treatment, in old primates to young control animals and young monkeys that receive lesions of the pineal gland (Px), SCN (SCNx) or both pineal and SCN (Px/SCNx). Subjects will be young (5...
- ROLE OF MELATONIN IN SECONDARY INSOMNIA IN THE ELDERLYNalaka Gooneratne; Fiscal Year: 2004..Recent work has suggested that melatonin, a neurohormone produced by the pineal gland and regulated by the suprachiasmatic nucleus, the primary circadian pacemaker, is decreased in elderly ..
- Small Molecule Ligand Discovery for Sleep Cycle DisordersScott Thacher; Fiscal Year: 2006..1 of these receptors, localized predominantly in the brain and highly expressed in the SCN and pineal gland, is predicted to respond to lipophilic small molecules capable of crossing the blood-brain barrier...
- REGULATION AND FUNCTION OF MELATONIN IN THE RETINAAllan Wiechmann; Fiscal Year: 1992Several laboratory studies indicate that the indolamine hormone melatonin, is synthesized by both the pineal gland and retina on a cyclic rhythm with peak levels during the dark period...
- EMF, OCPS, AND BREAST CANCER ON LONG ISLAND, NYLee Caplan; Fiscal Year: 1993..EMF) of about 60 hz might be associated with breast cancer by inhibiting secretion of melatonin by the pineal gland. By reducing melatonin secretion, it could be increasing estrogen production, a well established risk factor ..
- EMF AND BREAST CANCER ON LONG ISLANDM Leske; Fiscal Year: 2000..EMF) of about 60 hz might be associated with breast cancer by inhibiting secretion of melatonin by the pineal gland. By reducing melatonin secretion, it could be increasing estrogen production, a well established risk factor ..
- Seasonal Plasticity of Brain and BehaviorLeah Pyter; Fiscal Year: 2005..Photoperiod (day length) is used to determine time of year. Melatonin, secreted from the pineal gland in proportion to night-length, transduces photoperiodic information to evoke a suite of physiological, ..
- 2004 Pineal Cell Biology Gordon Research ConferenceElizabeth Maywood; Fiscal Year: 2004..The major objective of the Conference is to explore the molecular and cellular function of the pineal gland and how, via the nocturnal release of melatonin, the pineal contributes to the control of vertebrate physiology...
- MELATONIN AND NORMAL SLEEPINESSANDREW DOLLINS; Fiscal Year: 1993Pharmacologic doses (10 to 240 mg, p.o) of the hormone melatonin, which is normally secreted by the pineal gland at night, have been shown to produce daytime fatigue and performance changes normally associated with sleepiness...
- SLEEP AND CIRCADIAN RHYTHMS AFTER PINEAL RESECTIONMARIANA MACCHI; Fiscal Year: 2004The hormone melatonin, produced by the pineal gland, is thought to be involved in the regulation of human sleep, body temperature and circadian rhythms, but its mechanisms of action in these areas have not been fully clarified, while its ..
- S-ANTIGEN--CHARACTERIZATION OF T CELL CLONES IN UVEITISCARMEN MERRYMAN; Fiscal Year: 1992..autoimmune uveitis (EAU) and pinealitis (EAP), a severe inflammatory disease of the uveal tract, retina and pineal gland. Antigen-specific T cells are generated in Lewis rats by injection of S-antigen or peptide M, a synthetic ..
- RETINA SPECIFIC TRANSCRIPT MAP OF THE HUMAN GENOMEKim Worley; Fiscal Year: 2001..This will allow for a broadening of the scope of the searches to include additional tissues, such as pineal gland, searches for combinations of tissues or selecting the tissue specificity of ESTs on a ratio basis, e.g...
- EFFECTS OF MELATONIN ON MAMMARY AND UTERINE TUMOR GROWTHDavid Blask; Fiscal Year: 1990..is to further elucidate and understand the mechanisms by which melatonin (Mel), the major hormone of the pineal gland, inhibits the proliferation of hormone-responsive breast cancer in vivo and in vitro in both animal and human ..
- MELATONIN, HUMAN CIRCADIAN RHYTHMS, AND SLEEPCHARMANE EASTMAN; Fiscal Year: 2000..Melatonin is a hormone normally secreted by the pineal gland at night...
- PLASTICITY OF MAMMALIAN CIRCADIAN AXISGianluca Tosini; Fiscal Year: 2003..We have discovered that mammalian pineal gland, although not normally photosensitive, may become photosensitive when cultured...
- PHASE SHIFTING EFFECTS OF MELATONIN IN WINTER DEPRESSIONAlfred Lewy; Fiscal Year: 2001..The proposed study should further our understanding of light melatonin and biological rhythms in winter depression. ..
- Melatonin Studies of Totaly Blind ChildrenAlfred J Lewy; Fiscal Year: 2010..In a future grant application, we will assess feasibility of a large-scale, multi-center study of melatonin safety and efficacy, which may also be of benefit sighted people with circadian rhythm sleep and mood disorders ..
- Melatonin Entrainment of Elderly Blind Free-runnersAlfred Lewy; Fiscal Year: 2006..The study of blind people provides an opportunity to understand the physiology of the circadian system in humans unperturbed by the light/dark cycle. ..
- Molecular Dissection of Melatonin Synthesis In VivoJimo Borjigin; Fiscal Year: 2003..provided by applicant) Melatonin is a nocturnal hormone rhythmically synthesized and released from the pineal gland due to the actions of four enzymes: tryptophan hydroxylase (TPFI), aromatic amino acid decarboxylase (AAADC), ..
- PERMISSIVE RETINAL GENE EXPRESSION VIA HYPOMETHYLATIONJEFFREY BOATRIGHT; Fiscal Year: 2001..abstract_text> ..
- PHOTOPERIODIC CONTROL OF OBESITYTimothy Bartness; Fiscal Year: 2008..RESEARCH GRANT TABLE OF CONTENTS Page Numbers 1 Face Page .................................................................................................................................................. Description, ..
- FASEB Summer Research Conference 2008 - Melatonin Receptors: Actions and TherapeuDavid Blask; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..