decidua

Summary

Summary: The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.

Top Publications

  1. pmc WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 25:1176-87. 2011
  2. ncbi Multiple female reproductive failures in cyclooxygenase 2-deficient mice
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    Cell 91:197-208. 1997
  3. ncbi Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor
    Sarah Hamilton
    Maternal and Fetal Health Research Centre, University of Manchester, United Kingdom
    Biol Reprod 86:39. 2012
  4. ncbi Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term
    Inass Osman
    University of Glasgow, Department of Obstetrics and Gynaecology, 3rd Floor, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, UK
    Mol Hum Reprod 9:41-5. 2003
  5. ncbi Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Med 12:1065-74. 2006
  6. ncbi Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives
    Birgit Gellersen
    Endokrinologikum Hamburg, Hamburg, Germany
    Semin Reprod Med 25:445-53. 2007
  7. pmc Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
    Madhuri Salker
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 5:e10287. 2010
  8. pmc Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
  9. ncbi Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases
    Y Sasaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama, 930 0194, Japan
    Mol Hum Reprod 10:347-53. 2004
  10. pmc HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy
    Giada Amodio
    San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Immunol 74:406-11. 2013

Research Grants

Detail Information

Publications266 found, 100 shown here

  1. pmc WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 25:1176-87. 2011
    ..Thus, WNT4 is a critical regulator not only of proper postnatal uterine development, but also embryo implantation and decidualization...
  2. ncbi Multiple female reproductive failures in cyclooxygenase 2-deficient mice
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
    Cell 91:197-208. 1997
    ....
  3. ncbi Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor
    Sarah Hamilton
    Maternal and Fetal Health Research Centre, University of Manchester, United Kingdom
    Biol Reprod 86:39. 2012
    ..We hypothesized that inflammatory events in decidua (the maternal-fetal interface), characterized by leucocyte infiltration, are an early event during term and ..
  4. ncbi Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term
    Inass Osman
    University of Glasgow, Department of Obstetrics and Gynaecology, 3rd Floor, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, UK
    Mol Hum Reprod 9:41-5. 2003
    ..this study were to quantify and compare the leukocyte subpopulations before and during labour in fetal membranes, decidua and cervix and to quantify and compare mRNA expression of interleukin-1beta (IL-1beta), IL-6, IL-8 and tumour ..
  5. ncbi Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Med 12:1065-74. 2006
    Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts...
  6. ncbi Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives
    Birgit Gellersen
    Endokrinologikum Hamburg, Hamburg, Germany
    Semin Reprod Med 25:445-53. 2007
    The fetomaternal interface, consisting of the maternal decidua and the invading fetal trophoblast, critically regulates placental function and the growth and development of the conceptus...
  7. pmc Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
    Madhuri Salker
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 5:e10287. 2010
    ....
  8. pmc Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
    Natural killer cells constitute 50-90% of lymphocytes in human uterine decidua in early pregnancy...
  9. ncbi Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases
    Y Sasaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama, 930 0194, Japan
    Mol Hum Reprod 10:347-53. 2004
    ..In this study, we show that early human pregnancy decidua contains an abundance of CD4(+)CD25(bright) T cells, which express CD152(CTLA-4) at a high level...
  10. pmc HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy
    Giada Amodio
    San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Immunol 74:406-11. 2013
    ..We investigated the presence of DC-10 and HLA-G-expressing CD4(+) T cells in human decidua in the first trimester of pregnancy...
  11. ncbi Isolation and cellular properties of mesenchymal cells derived from the decidua of human term placenta
    Daisuke Kanematsu
    Department of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, 2 1 14 Hoenzaka, Chuo Ku, Osaka 540 0006, Japan
    Differentiation 82:77-88. 2011
    ..In this study, we isolated plastic-adherent cells from human term decidua vera, called decidua-derived-mesenchymal cells (DMCs), and compared their properties with those of bone marrow-..
  12. ncbi Review: Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua
    G E Lash
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Placenta 31:S87-92. 2010
    ..Herein we review the functional roles of this important decidual cell type...
  13. pmc Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface
    Patrice Nancy
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Science 336:1317-21. 2012
    ..We show in mice that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta...
  14. pmc A transcriptional profile of the decidua in preeclampsia
    Mari Løset
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Obstet Gynecol 204:84.e1-27. 2011
    We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis.
  15. pmc Endometrial decidualization: of mice and men
    Cyril Y Ramathal
    Department of Cell and Developmental Biology, University of Illinois Urbana Champaign, Urbana, Illinois 61801, USA
    Semin Reprod Med 28:17-26. 2010
    ....
  16. ncbi Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia
    Nat Med 4:303-8. 1998
    ..embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue known as the decidua. The decidua encapsulates the developing embryo, facilitating nutrient transfer and limiting trophoblast invasion...
  17. pmc Prokineticin 1 signaling and gene regulation in early human pregnancy
    Jemma Evans
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:2877-87. 2008
    ..PROK1 and PROKR1 expression is significantly elevated in first-trimester decidua, compared with nonpregnant endometrium...
  18. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
    ..to initiate normal pregnancy-induced modification of decidual arteries and display hypocellularity or necrosis of decidua. To investigate the functions of uNK cell-derived IFN-gamma during pregnancy, RAG-2(-/)-gamma(c)(-/)- females ..
  19. pmc Wnt signalling in implantation, decidualisation and placental differentiation--review
    S Sonderegger
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Placenta 31:839-47. 2010
    ..Hence, much remains to be learned about the role of different Wnt signalling cascades in reproductive cell types and their changes under pathological conditions...
  20. ncbi Invasion of the leukocytes into the fetal-maternal interface during pregnancy
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Universityof Alberta, Edmonton, Alberta, Canada
    J Leukoc Biol 88:625-33. 2010
    ..In this review, we discuss leukocyte infiltration and recruitment and the potential roles of each subpopulation of leukocytes in relation to pregnancy and the problems of preterm birth, pre-eclampsia, and intrauterine growth restriction...
  21. pmc Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype
    Charlotte Gustafsson
    Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    PLoS ONE 3:e2078. 2008
    ..Although uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface, their global gene expression profile is not known...
  22. ncbi Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy
    Tamara Tilburgs
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    J Immunol 180:5737-45. 2008
    ..These data suggest a preferential recruitment of fetus-specific regulatory T cells from maternal peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation of fetus-specific responses...
  23. ncbi FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua
    Jenny Mjösberg
    Unit for Autoimmunity and Immune Regulation, Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Biol Reprod 82:698-705. 2010
    In pregnancy, the decidua is infiltrated by leukocytes promoting fetal development without causing immunological rejection. Murine regulatory T (Treg) cells are known to be important immune regulators at this site...
  24. ncbi Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization
    Xiao Huan Liang
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Science, Xiamen University, Xiamen 361005, China
    Endocrinology 151:5007-16. 2010
    ..In this study, we first showed that Abp1 is strongly expressed in the decidua on d 5-8 of pregnancy...
  25. ncbi The immunomodulatory roles of macrophages at the maternal-fetal interface
    Takeshi Nagamatsu
    Division of Perinatal Research, Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, Missouri 65201, USA
    Reprod Sci 17:209-18. 2010
    ..In the uterine decidua, macrophages represent a major leukocyte subset throughout pregnancy...
  26. ncbi The unique properties of uterine NK cells
    Irit Manaster
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, IMRIC, Jerusalem, Israel
    Am J Reprod Immunol 63:434-44. 2010
    ..We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy.
  27. pmc Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
    Yasushi Hirota
    The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio, USA
    J Clin Invest 120:803-15. 2010
    ..Taken together, our observations underscore what we believe to be a new critical role of uterine p53 in parturition...
  28. pmc Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors
    B C Paria
    Department of Pediatrics, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City, KS 66160 7338, USA
    Proc Natl Acad Sci U S A 98:1047-52. 2001
    ..Significantly, beads containing BMP-2 do not themselves elicit an implantation response but affect the spacing of implantation sites induced by blastocysts cotransferred with the beads...
  29. pmc Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss
    Madhuri S Salker
    Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
    PLoS ONE 7:e52252. 2012
    ..Failure to constrain this response predisposes to miscarriage by allowing out-of-phase implantation in an unsupportive uterine environment...
  30. ncbi MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts
    S E Segerer
    Department of Obstetrics and Gynaecology, University of Wuerzburg, Josef Schneider Straße 4, Wuerzburg D 97080, Germany
    Hum Reprod 27:200-9. 2012
    ..So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy...
  31. ncbi Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term
    Anne Young
    Department of Obstetrics and Gynaecology, Queen Elizabeth Building, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, United Kingdom
    Biol Reprod 66:445-9. 2002
    ..In fetal membranes, IL-1beta localized to leukocytes and to the stromal cells of the decidua. In myometrium, IL-6, IL-8, and TNFalpha were restricted to leukocytes, which were present in greater numbers in ..
  32. ncbi Decidualization and angiogenesis in early pregnancy: unravelling the functions of DC and NK cells
    Sandra M Blois
    Charité Centrum 12 für Innere Medizin und Dermatologie, Reproductive Immunology Research Group, University Medicine of Berlin, Germany
    J Reprod Immunol 88:86-92. 2011
    ..Thus, successful implantation appears to result from an interplay between cellular components of the decidualizing endometrium involving immunoregulatory and pro-angiogenic functions of DC and NK cells...
  33. pmc The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy
    Hai Lan Piao
    Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China
    Cell Mol Immunol 9:423-30. 2012
    ..Our present study has elucidated the individual contributions of component cells to the shaping of Th2 bias, and uncovered a complicated cross-talk via the CXCL12/CXCR4 signal at the maternal/fetal interface in early human pregnancy...
  34. pmc De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis
    Amrita Das
    Center for Research in Reproduction and Infertility, and Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 106:12542-7. 2009
    ..Collectively, these studies identified the decidual uterus as a novel site of E biosynthesis and uncovered E-regulated maternal signaling pathways that critically control uterine differentiation and angiogenesis during early pregnancy...
  35. pmc Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus
    Jae Hee Lee
    Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University College of Human Medicine, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA
    FASEB J 27:2553-63. 2013
    ..Our results suggest that STAT3 and PR crosstalk is required for successful implantation in the mouse uterus...
  36. ncbi Pericellular matrix of decidua-derived mesenchymal cells: a potent human-derived substrate for the maintenance culture of human ES cells
    Tomoko Nagase
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe, Japan
    Dev Dyn 238:1118-30. 2009
    ..In this report, we show that the pericellular matrix prepared from human decidua-derived mesenchymal cells (PCM-DM) is a potent substrate material that supports the growth and pluripotency of ..
  37. ncbi Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells
    Wei Guo
    Immunology and Reproduction Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China
    Am J Reprod Immunol 67:463-73. 2012
    ..Uterine natural killer cells (uNK) do not express progesterone receptor, but express glucocorticoid receptor (GR). So, we speculate that progesterone may regulate uNK cells through a GR-mediated process...
  38. ncbi Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases
    Jelena Anacker
    Department of Obstetrics and Gynaecology, University Hospital of Wurzburg, Germany
    Mol Hum Reprod 17:637-52. 2011
    ..There is evidence for the expression of several MMPs and TIMPs in decidua. However, published data are limited...
  39. ncbi The postimplantation embryo differentially regulates endometrial gene expression and decidualization
    Aki Kashiwagi
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Harvard Medical School, Thier Research Building, Room 931, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Endocrinology 148:4173-84. 2007
    ..05) were differentially expressed by at least 1.2-fold in the uterine decidua of pregnancy...
  40. ncbi IFPA Gabor Than Award lecture: Transformation of the spiral arteries in human pregnancy: key events in the remodelling timeline
    L K Harris
    Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK
    Placenta 32:S154-8. 2011
    ..Parallels with remodelling events occurring in other vascular beds will also be drawn...
  41. ncbi IFPA Meeting 2010 Workshops Report II: Placental pathology; trophoblast invasion; fetal sex; parasites and the placenta; decidua and embryonic or fetal loss; trophoblast differentiation and syncytialisation
    A Al-Khan
    Department of Obstetrics and Gynaecology, University of California San Diego, San Diego, CA, USA
    Placenta 32:S90-9. 2011
    ..5. The decidua and embryonic/fetal loss workshop focused on key regulatory mediators in the decidua, embryo and fetus and how ..
  42. ncbi The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, 05508 900 Sao Paulo, SP Brazil
    Cell Mol Biol (Noisy-le-grand) 49:673-8. 2003
    ..These results strongly indicate that biglycan plays a role in collagen fibrillogenesis and probably participates in the determination of collagen fibril thickness in the mouse decidua.
  43. pmc Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium
    Roberta Bulla
    Department of Physiology and Pathology, University of Trieste, Via Fleming 22, 34127, Trieste, Italy
    Mol Immunol 45:2629-40. 2008
    ....
  44. pmc Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodeling
    Lynda K Harris
    Maternal and Fetal Health Research Centre, University of Manchester, Manchester Academic Health Science Centre, St Mary s Hospital, Manchester, United Kingdom
    Am J Pathol 177:2103-15. 2010
    ....
  45. pmc Two unique human decidual macrophage populations
    Brandy L Houser
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    J Immunol 186:2633-42. 2011
    ..also differ from CD11c(LO) dMs in their ability to process protein Ag and are likely to be the major APCs in the decidua. Moreover, these populations each secrete both proinflammatory and anti-inflammatory cytokines that may ..
  46. pmc The effect of pregnancy on the uterine NK cell KIR repertoire
    Victoria Male
    Department of Pathology and Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Eur J Immunol 41:3017-27. 2011
    The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast...
  47. ncbi Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age
    Andrew M Sharkey
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 181:39-46. 2008
    ..KIR specific for HLA-C are expressed at higher levels and on an increased proportion of NK cells in the human decidua compared with blood...
  48. pmc Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Reprod 78:1064-72. 2008
    Extravillous trophoblasts (EVTs) invade human decidua via sequential integrin-mediated binding and proteolysis of basement membrane proteins in the extracellular matrix (ECM)...
  49. ncbi Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation
    M von Wolff
    Department of Gynecological Endocrinology and Reproductive Medicine, Universitatsklinikum Heidelberg, Vossstrasse 9, 69115 Heidelberg, Germany
    Mol Hum Reprod 11:189-94. 2005
    ..e. galectins. Comprehensive fingerprinting was performed on samples throughout the menstrual cycle and in decidua. The endometrium (n = 30) and decidua (n = 7) were collected from patients undergoing hysterectomy for benign ..
  50. pmc Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity
    Petra A B Klemmt
    Nuffield Department of Obstetrics and Gynaecology, The Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Fertil Steril 85:564-72. 2006
    ..To evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis...
  51. ncbi Review: Trophoblast-vascular cell interactions in early pregnancy: how to remodel a vessel
    L K Harris
    Maternal and Fetal Health Research Group, University of Manchester, Research 5th floor, St Mary s Hospital, Oxford Road, Manchester, M13 9WL, UK
    Placenta 31:S93-8. 2010
    During the first twenty weeks of human pregnancy, extravillous trophoblasts (EVT) colonise the decidua and remodel the uterine spiral arteries as far as the first third of the myometrium...
  52. pmc Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy
    Samantha D Smith
    Maternal and Fetal Health Research Group, Research Floor, St Mary s Hospital, Manchester, UK
    Am J Pathol 174:1959-71. 2009
    ..b>Decidua basalis samples (8 to 12 weeks gestation) were examined by immunohistochemistry to elucidate associations between ..
  53. ncbi CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Blood 102:1569-77. 2003
    In the maternal decidua, natural killer (NK) cells, characterized by lack of CD16, are found in direct contact with the fetal extravillous trophoblasts (EVTs)...
  54. pmc Bmp2 is critical for the murine uterine decidual response
    Kevin Y Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 27:5468-78. 2007
    ..Taken together, these data demonstrate that Bmp2 is a critical regulator of gene expression and function in the murine uterus...
  55. ncbi The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice
    D G Ogando
    Centro de Estudios Farmacologicos y Botanicos, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Serrano 669, Capital Federal, 1414MEM, Buenos Aires, Argentina
    Reproduction 125:95-110. 2003
    ..This increase was due to the induction of expression of inducible nitric oxide synthase (iNOS) isoform in the decidua and uterus, and neuronal nitric oxide synthase (nNOS) isoform in the decidua, as detected by western blot ..
  56. pmc A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1
    Richard Apps
    Department of Pathology, Cambridge University, Cambridge, UK
    Eur J Immunol 37:1924-37. 2007
    ..individuals, the non-classical MHC molecule HLA-G is only expressed on fetal trophoblast cells that invade the decidua during placentation...
  57. pmc Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia
    Y Sasaki
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Clin Exp Immunol 149:139-45. 2007
    ..These findings suggest that a decreased number of T(reg) cells was present in pre-eclampsia, and these changes might break the maternal tolerance to the fetus...
  58. pmc Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface
    Satyan S Kalkunte
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    J Immunol 182:4085-92. 2009
    ..Overall, these results demonstrate that empowerment of uNK cells with angiogenic factors keeps them noncytotoxic. This phenotype is critical to their pregnancy-compatible immunovascular role during placentation and fetal development...
  59. ncbi Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients
    Hui Yang
    Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Fertil Steril 89:656-61. 2008
    To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women.
  60. ncbi Isolation of mesenchymal stem cells from human placental decidua basalis and resistance to hypoxia and serum deprivation
    Yong Can Huang
    Division of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, People s Republic of China
    Stem Cell Rev 5:247-55. 2009
    ..We herein report the isolation of a population of stem cells from the human placental decidua basalis (termed as PDB-MSCs), a maternal portion of placenta...
  61. ncbi Macrophages and apoptotic cell clearance during pregnancy
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Reprod Immunol 51:275-82. 2004
    During implantation, apoptosis is critical for the appropriate tissue remodeling of the maternal decidua and invasion of the developing embryo, yet the regulation of apoptosis is also imperative for a successful pregnancy...
  62. ncbi When killers become helpers
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
    Trends Immunol 28:201-6. 2007
    ..Such functions include promoting placental tissue development, antigen presentation and stimulation of T cells, priming of macrophages and dendritic cells, reducing transplant tissue rejection and several others...
  63. pmc Human decidual NK cells form immature activating synapses and are not cytotoxic
    Hernan D Kopcow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:15563-8. 2005
    ..However, in contrast to peripheral NK cells, they failed to polarize their microtubule organizing centers and perforin-containing granules to the synapse, accounting for their lack of cytotoxicity...
  64. pmc Phenotypic characterization of regulatory T cells in the human decidua
    J Heikkinen
    Department of Medical Microbiology, Turku Graduate School of Biomedical Sciences, Turku University, Finland
    Clin Exp Immunol 136:373-8. 2004
    ..We have studied and identified a CD4+CD25+ regulatory T (Treg) cell population isolated from the human decidua. This mucosal surface in the uterus is in direct contact with semiallogenic fetal cells...
  65. ncbi In vitro secretion profile of pro-inflammatory cytokines IL-1β, TNF-α, IL-6, and of human beta-defensins (HBD)-1, HBD-2, and HBD-3 from human chorioamniotic membranes after selective stimulation with Gardnerella vaginalis
    Veronica Zaga-Clavellina
    Cell Biology Department, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Am J Reprod Immunol 67:34-43. 2012
    ..Preterm labor associated with infection is a major clinical condition; in this work, we analyze the response of human chorioamniotic membranes stimulated with Gardnerella vaginalis...
  66. ncbi Differential expression and activation of Stat3 during mouse embryo implantation and decidualization
    Chun Bo Teng
    College of Life Sciences, Northeast Agricultural University, Harbin, China
    Mol Reprod Dev 69:1-10. 2004
    ..Our data suggest that Stat3 phosphorylation may be important for mouse embryo implantation and decidualization, and may also be regulated by maternal estrogen...
  67. ncbi A novel immortalized human endometrial stromal cell line with normal progestational response
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Endocrinology 145:2291-6. 2004
    ..In summary, an immortalized HESC line has been developed that is karyotypically, morphologically, and phenotypically similar to the primary parent cells, and it is a powerful and consistent resource for in vitro work...
  68. ncbi Osteopontin: roles in implantation and placentation
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 69:1458-71. 2003
    ..OPN has the potential to profoundly impact pregnancy, and investigators are now challenged to focus on the mechanistic nature of the functions of this multifaceted and major component of the uterine-placental microenvironment...
  69. ncbi Signal transducer and activator of transcription 3 is expressed in the decidualized mesometrium of pregnancy and associates with the progesterone receptor through protein-protein interactions
    Tongyun Liu
    Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
    Biol Reprod 67:114-8. 2002
    ..e., decidua basalis) of the rat during pregnancy and its interactions with the progesterone-progesterone receptor (PR) system...
  70. ncbi Accumulation of IL-17-positive cells in decidua of inevitable abortion cases
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 64:4-11. 2010
    ..It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion...
  71. ncbi Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2
    D A Clark
    Department of Medicine, Pathology and Molecular Medicine, and Department of Obstetrics and Gynecology, McMaster University, 1200 Main St West, Room 3V39, Hamilton, Ontario, Canada L8N 3Z5
    Mol Hum Reprod 7:185-94. 2001
    ..Here we show that Th1 cytokines up-regulate fgl2 mRNA in fetal trophoblast and secondary decidua of CBA/JxDBA/2 and CBA/JxBALB/c matings, and promote fibrin deposition...
  72. ncbi Notch activation enhances IFNgamma secretion by human peripheral blood and decidual NK cells
    Irit Manaster
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, The BioMedical Research Institute, Jerusalem, Israel
    J Reprod Immunol 84:1-7. 2010
    ..Finally, we show that Notch activation in these cells leads to increased secretion of IFNgamma. We therefore present here a new function of the Notch receptors as enhancers of peripheral blood NK cell and decidual NK cell functions...
  73. pmc Subfertility linked to combined luteal insufficiency and uterine progesterone resistance
    Toshihiro Konno
    Institute of Maternal Fetal Biology, and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrinology 151:4537-50. 2010
    ..BN uterine decidua was shown to be both structurally and functionally distinct and correlated with decreased circulating ..
  74. ncbi The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation
    S Afonso
    Department of Cell, Developmental and Neurobiology, Nelson Labs, Busch Campus, Rutgers University, Piscataway, NJ 08855, USA
    Development 124:3415-25. 1997
    ..5-8.5). With the regression of the decidua beginning on day 9...
  75. pmc Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization
    D V Huyen
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Reproduction 142:353-68. 2011
    ....
  76. pmc Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells
    Hayato Fukusumi
    Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan
    PLoS ONE 8:e55226. 2013
    ..We previously reported that the pericellular matrix of decidua-derived mesenchymal cells (PCM-DM) is an ideal human-derived substrate on which to maintain hiPSCs/hESCs...
  77. ncbi HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells
    A King
    Department of Pathology, University of Cambridge
    Eur J Immunol 30:1623-31. 2000
    ..The uterine mucosa in early pregnancy (decidua) is infiltrated by large numbers of NK cells, which are closely associated with placental trophoblast cells...
  78. ncbi IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau
    G Chaouat
    INSERM CJF 92 09, Antoine Beclere Hospital, Clamart, France
    J Immunol 154:4261-8. 1995
    ..These results indicate that the placentally produced anti-inflammatory cytokines can play a vital role in the survival to term of the fetal allograft, by counteracting deleterious inflammatory cytokines...
  79. ncbi Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age
    Gendie E Lash
    Uterine Cell Signalling Group, Institute of Cellular Medicine and School of Medical Development and Education, Newcastle University, 3rd Floor, William Leech Building, Newcastle upon Tyne NE2 4HH, UK
    Hum Reprod 25:1137-45. 2010
    Extravillous trophoblast (EVT) cell invasion of uterine decidua and the inner third of myometrium is critical for successful pregnancy. Many decidual factors are likely to play a role in regulating this process...
  80. ncbi Predominance of Th2-promoting dendritic cells in early human pregnancy decidua
    Satomi Miyazaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Japan
    J Leukoc Biol 74:514-22. 2003
    ..we describe the characterization of CD45+CD3-CD14-CD16-CD19-CD20-CD56-HLA-DRbright DCs from early human pregnancy decidua by flow cytometry...
  81. pmc Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro
    Aleah D Hazan
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 177:1017-30. 2010
    ..001) before trophoblast presence in the vessel lumens. These events did not occur in decidua-only cultures...
  82. pmc The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua
    Pawel Basta
    Department of Gynecology and Oncology of the Jagiellonian University, Krakow, Poland
    Reprod Biol Endocrinol 8:116. 2010
    ..of Treg cells in conditions where a disturbance in the immunological equilibrium in ectopic endometrium and decidua has been observed, such as in cases of ovarian endometriosis (involving local immune cell suppression) and ..
  83. ncbi Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies
    T B Knudsen
    Department of Anatomy, East Tennessee State University, James H Quillen College of Medicine, Johnson City 37614
    Biol Reprod 44:171-84. 1991
    ..placental). In the first phase, ADA enzyme activity increased almost 200-fold in the antimesometrial region (decidua capsularis + giant trophoblast cells) from Days 6 through 9 of gestation but remained low in the mesometrial ..
  84. pmc Transcription factor CCAAT enhancer-binding protein beta (C/EBPbeta) regulates the formation of a unique extracellular matrix that controls uterine stromal differentiation and embryo implantation
    Cyril Ramathal
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 286:19860-71. 2011
    ....
  85. pmc Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates
    Yalda Afshar
    Department of Physiology and Biophysics, University of Illinois, Chicago, Illinois 60607, USA
    Endocrinology 153:2884-96. 2012
    ..Subsequently, Notch1 down-regulation may be critical for the transition of stromal fibroblast to decidual cells, which is essential for the establishment of a successful pregnancy...
  86. pmc Induction of overt menstruation in intact mice
    Marion Rudolph
    Target Discovery, Global Drug Discovery, Bayer HealthCare, Berlin, Germany
    PLoS ONE 7:e32922. 2012
    ....
  87. ncbi Differential activity of the gelatinases (matrix metalloproteinases 2 and 9) in the fetal membranes and decidua, associated with labour
    S Goldman
    Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha Emek Medical Center, 18101, Afula, Israel
    Mol Hum Reprod 9:367-73. 2003
    ..been implicated in the rupture of fetal membranes, the process of parturition and placental detachment from the decidua after parturition...
  88. ncbi The placenta in preterm birth
    O M Faye-Petersen
    The University of Alabama at Birmingham, Birmingham, AL 35249 7331, USA
    J Clin Pathol 61:1261-75. 2008
    ..A brief summary of the placental gross and histopathological findings in indicated preterm birth is also included...
  89. ncbi IL-15 expression at human endometrium and decidua
    K Kitaya
    Department of Obstetrics and Gynecology and Dynamic Pathology Research Institute, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Biol Reprod 63:683-7. 2000
    ..of interleukin (IL)-15, a possible stimulator for these NK cells, in human endometrium and first trimester decidua. Semiquantitative reverse transcriptase-polymerase chain reaction revealed that IL-15 mRNA expression was ..
  90. ncbi Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells
    J D Greenwood
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Placenta 21:693-702. 2000
    ..include the absence of aggregation of lymphocytes in the mesometrial triangle, acellularity of the mesometrial decidua, decidual arteries with relatively thick walls and reduced lumen diameters, unusual prominence of the endothelium ..
  91. ncbi The pathology of placenta accreta, a worldwide epidemic
    T Y Khong
    SA Pathology, Women s and Children s Hospital, North Adelaide, Australia
    J Clin Pathol 61:1243-6. 2008
    ..Pathological diagnosis relies on the finding of placental villi in direct apposition to myometrium, either in hysterectomy specimens or in placental basal plates...
  92. ncbi The urokinase plasminogen activator (uPA) system in uterine natural killer cells in the placental bed during early pregnancy
    K Naruse
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Placenta 30:398-404. 2009
    ..Caseinase activity was stronger in decidua than myometrium as shown by in situ zymography. uPA localised strongly to uNK cells, especially at 8-10 weeks...
  93. ncbi MUC1 expression is increased during human placental development and suppresses trophoblast-like cell invasion in vitro
    Ming Kwang Shyu
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, 100 Taipei, Taiwan
    Biol Reprod 79:233-9. 2008
    ..Interestingly, we found two populations of extravillous trophoblasts, MUC1-positive and MUC1-negative cells, in decidua. The numbers of MUC1-positive extravillous trophoblasts were increased during placental development...
  94. ncbi Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions
    Takeshi Nagamatsu
    Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, One Hospital Drive, Columbia, MO 65201, USA
    Hum Reprod 24:3160-71. 2009
    ..B7-H1 and B7-DC on peripheral antigen-presenting cells (APC) typically inhibit T cell activation after binding to their corresponding receptor, programmed death-1 (PD-1)...
  95. pmc The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
    Lorraine Clark
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Genet 3:11. 2002
    ..Although other genes in this chromosomal region show conserved synteny with genes on human Chr11p15.5, there are no obvious human orthologues of Tnfrh1 or Tnfrh2...
  96. ncbi The developmental role of natural killer cells at the fetal-maternal interface
    Simcha Yagel
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Centers, Mt Scopus, Jerusalem, Israel
    Am J Obstet Gynecol 201:344-50. 2009
    ..NK (eNK) cells, found in the uterus during the menstrual cycle, and decidual NK (dNK) cells, found in the decidua during pregnancy...
  97. ncbi Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes: the effect of prostaglandin F(2alpha) and indomethacin
    U Ulug
    Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula, Israel
    Mol Hum Reprod 7:1187-93. 2001
    Degradation and breakdown of gestational membranes and the adjacent decidua are essential processes for the advancement of labour...
  98. ncbi Invasiveness of human endometrial stromal cells is promoted by decidualization and by trophoblast-derived signals
    B Gellersen
    Endokrinologikum Hamburg, 20251 Hamburg, Germany
    Hum Reprod 25:862-73. 2010
    Extensive invasion of the maternal decidua by extravillous trophoblast is considered of critical importance for implantation and placentation in humans, the decidua being viewed as a passively invaded tissue...
  99. ncbi Interleukin-10 is produced by human uterine natural killer cells but does not affect their production of interferon-gamma
    P Vigano
    Molecular Biology Laboratory, Istituto Auxologico Italiano, V le Monte Nero 32, 20135 Milan, Italy
    Mol Hum Reprod 7:971-7. 2001
    ..However, IL-10 produced by uNK cells in response to IL-12 and IL-2 may still have a feedback inhibitory effect on the production of deleterious cytokines within the uterine microenvironment...
  100. ncbi Developmental cell biology of human villous trophoblast: current research problems
    John D Aplin
    Maternal and Fetal Health Research Group, University of Manchester, UK
    Int J Dev Biol 54:323-9. 2010
    ..Maternally delivered insulin-like growth factors stimulate growth and might be therapeutically useful when endogenous growth pathways falter...
  101. ncbi Mouse models of implantation
    Kevin Y Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Trends Endocrinol Metab 18:234-9. 2007
    ..This review describes the evolution of the mouse as a model for understanding uterine implantation, including exciting new advances in this field, and describes a novel genetic pathway that can be elucidated from these models...

Research Grants63

  1. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    Implanting human cytotrophoblasts (CTBs) invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (MFs) and dendritic cells (DCs)...
  2. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..While invasion of the uterine decidua and the proximate inner third of the myometrium by EVT is a characteristic feature of a healthy pregnancy, ..
  3. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..Multiple mechanisms contribute to implantation tolerance. Maternal leukocytes that populate the uterine decidua certainly play an important role...
  4. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    ..Accumulation of fluid in the placental-fetal unit also suggests lymphatic vessels in the decidua have diminished capacity to remove excess fluid...
  5. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ..Maternal leukocytes that populate the uterine decidua certainly play an important role in tolerance...
  6. Epigenetic regulation of decidual inflammation
    Adrian Erlebacher; Fiscal Year: 2013
    ..In particular, little is known about the intrinsic inflammatory characteristics of the decidua, the specialized uterine stromal tissue that surrounds the fetus and placenta...
  7. FUNCTIONS OF PREGNANCY SPECIFIC GLYCOPROTEINS
    Gabriela S Dveksler; Fiscal Year: 2010
    ..environment that is compatible with pregnancy success, as macrophages constitute a stable population in the decidua responsible for generating local innate immunity throughout pregnancy...
  8. Immune responses to infection at the maternal-fetal interface
    Gabrielle A Rizzuto; Fiscal Year: 2013
    ..We hypothesize that the maternal immune cells of the placenta, specifically the macrophages located in the decidua (lining of the pregnant uterus), defend this organ against pathogens in a unique manner...
  9. Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia
    Susan J Fisher; Fiscal Year: 2013
    ..The interstitial component of cytotrophoblast (CTB) invasion is frequently restricted to the superficial decidua. Likewise, endovascular invasion is constrained in terms of the number of spiral arterioles that are involved and ..
  10. Role of Host Cells in Invasive Listeriosis
    Anna Bakardjiev; Fiscal Year: 2013
    ..a small subpopulation of fetally derived cells (extravillous cytotrophoblasts), which anchor the placenta in the decidua, the lining of the pregnant uterus...
  11. Renal Cell Tumor-Mediated Trans-differentiation of Natural Killer Cells
    ANDREW CHRISTROPHER WILBER; Fiscal Year: 2013
    ..Large influxes of maternal NK cells into the decidua occurs during normal embryo implantation...
  12. EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
    Michael Gravett; Fiscal Year: 2005
    ..Samples of the decidua, fetal membranes, tissues, and brain will be obtained at cesarean section for microbiologic, histopathologic ..
  13. Phospholipid-reactive T cells in Pregnancy Loss
    RAMESH CHANDRA HALDER; Fiscal Year: 2012
    ..of PL-reactive T cells in lymphoid organs;such T cells will infiltrate the pregnant uterine mucosa, called decidua, in increased numbers...
  14. CYTOKINE REGULATION OF UTERINE OXYTOCIN RECEPTOR
    PHILLIP RAUK; Fiscal Year: 2001
    ..Oxytocin receptors in both the myometrium and decidua increase sharply immediately prior to labor...
  15. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 1993
    ..The proposed studies use the same general approach: uterine cells are harvested from pregnancy tissues (decidua, metrial gland, uterus) at mid to late gestation as well as from deciduoma and are fractionated into macrophage-..
  16. EFFECTS OF COCAINE ON PLACENTAL GROWTH FACTORS
    Kathleen Shiverick; Fiscal Year: 1993
    ..Isolated labyrinth, basal zone and decidua portions of the placenta will be weighed and examined histologically for evidence of hemorrhage and abruptions...
  17. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    Relaxin is a heterodimeric peptide hormone produced by the corpus luteum, decidua, and placenta in pregnant and nonpregnant females attaining the highest plasma levels during pregnancy...
  18. INHIBITION OF UTERINE CONTRACTIONS BY FETAL MEMBRANES
    Patricia Collins; Fiscal Year: 1999
    ..The fetal membranes, the amjiion and chorion, and the maternal decidua are thought to be important in paracrine signalling and control of uterine contractions, cervical dilation and ..
  19. PREECLAMPSIA LINKAGE TO PLACENTAL IMPLANTATION-PERFUSION
    Robert Taylor; Fiscal Year: 1992
    ..Examination of the monkey's decidua and placentas will determine if differences found in these tissues are the cause or result of reduced trophoblast ..
  20. The Molecular Pathogenesis of Health Disparities in Inf*
    Emmet Hirsch; Fiscal Year: 2005
    ..labor without infection; and D. no infection/no labor. RNA will then be collected from myometrium, ovaries, decidua, placentas and fetal membranes from each of the groups in a time series, and the relative expression of thousands ..
  21. ADENOSINE DEAMINASE--TARGET IN MOLECULAR TERATOGENESIS
    Thomas Knudsen; Fiscal Year: 1993
    ..complementary DNA (cDNA) sequences will be used to probe the embryo, extraembryonic membranes and maternal decidua for ADA mRNA in Northern blots and to spatially localize these transcripts by in situ hybridization...
  22. CYTOMATION MOFLO MLS FLOW CYTOMETER
    Michael Axthelm; Fiscal Year: 1999
    ..of cell subpopulations in peripheral blood, lymph nodes, thymus, bone marrow, amniotic fluid, chorion and decidua, corpus luteum, and human, monkey and mouse brain...
  23. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
    ..decidualization of human endometrial stromal interactions between the human trophoblast and the maternal decidua in an effort to understand paracrine mechanisms operating in the placental bed during the invasive phase of human ..
  24. Prolactin regulation of decidual activin and apoptosis
    Jennifer Bowen Shauver; Fiscal Year: 2003
    During normal pregnancy, the decidua undergoes a tightly regulated process of apoptotic regression to accommodate the developing fetus...
  25. Gap Junctions in Placental Development
    Stephen Lye; Fiscal Year: 2004
    ..In Aim Ill, we will utilize a trophoblast-decidua explant co-culture system to determine how the decidua modifies GJICmediated EVT differentiation...
  26. Primate Endometrial Responses to Placental MHC Class I Molecules
    Thaddeus Golos; Fiscal Year: 2009
    ..hypothesize that Mamu-AG interacts with decidual NK cells to promote appropriate responses in the early pregnancy decidua, including the differentiation and distribution of macrophages and T cells, the modification of smooth muscle in ..
  27. INTERLEUKIN-1 IN HUMAN PREGNANCY
    Roberto Romero; Fiscal Year: 1991
    ..the onset of premature labor associated with inflammation of infectious origin in reproductive tissues (decidua, placenta, chorioamnion) and the fetus...
  28. CYTOKINES AND NK CELL DIFFERENTIATION IN RODENT DECIDUA
    Judith Head; Fiscal Year: 1999
    ..in both rodents and humans, natural killer (NK)-lineage cells accumulate in large numbers in the maternal tissue (decidua) at the implant site, then in a unique structure in rodents, the metrial gland...
  29. MOLECULAR ENDOCRINOLOGY OF THE UTERUS
    Elizabeth Stewart; Fiscal Year: 2001
    ..that the alpha-subunit of hCG has a role in the regulation of prolactin production by uterine myometrium and decidua. However, the mechanism of this effect is not understood because alpha-subunit alone appears to have no effect ..
  30. HORMONE-ACTION AND CYTOKINE REGULATION OF DECIDUA CELLS
    CHARLES CHAFFIN; Fiscal Year: 2003
    ..abstract_text> ..
  31. IGF BINDING PROTEINS AND HUMAN ENDOMETRIUM
    Linda Giudice; Fiscal Year: 2000
    ..the major IGF binding protein produced in endometrium during the peri-implantation period and in the endometrium (decidua) of pregnancy...
  32. A NOVEL MECHANISM UNDERLYING THE ROLE OF VEGF IN PPROM
    Ljubica Bogic; Fiscal Year: 2002
    ..As reported in our preliminary data, gene expression of VEGF in maternal decidua was elevated in patients with PPROM compared to those with preterm labor...
  33. AUTOMATED DNA SEQUENCER
    Gabor Mocz; Fiscal Year: 1999
    ..These are as follows: I. Human Decidua and Fetal Membranes as a Paracryne system, 2. Elastin Gene in Pseudoxanthoma Elasticum; 3...
  34. BIOMOLECULAR BASIS OF INFECTION-INDUCED PRETERM LABOR
    Susan Cox; Fiscal Year: 1990
    ..labor is caused by bioactive agents of infection that serve to effect increased prostaglandin formation in decidua. Based on this proposition, the long-range goals of the research proposed are (i) define the biomolecular events ..
  35. IGF EXPRESSION IN NORMAL AND DIABETIC PREGNANCY
    Judith Ilan; Fiscal Year: 1991
    ..The involvement of these genes in the development of the decidua as well as extra embryonic structures in normal and diabetic pregnancies will be analyzed...
  36. REGULATION OF HUMAN DECIDUAL PROLACTIN
    Rebecca Jackson; Fiscal Year: 1992
    ..Recent studies have shown that the cells of the human decidua have the capacity to synthesize and secrete prolactin during different phases of the normal menstrual cycle and ..
  37. CELLULAR IMMUNITY--RECURRENT SPONTANEOUS ABORTION
    Joseph Hill; Fiscal Year: 1991
    ..new monoclonal antibodies to lymphocyte and monocyte markers to compare immune mediators in the endometrium and decidua of women with recurrent abortion with those in normal controls...
  38. HSF 1 Requirements in Extraembryonic Development
    Ivor Benjamin; Fiscal Year: 2005
    ..the spongiotrophoblast layer through signaling pathways based on cross-talk between placental cells and maternal decidua. Two independent and unbiased approaches will be used as discovery platforms to identify, isolate, and ..
  39. The Immune Paradox of Human Pregnancy: Fetal Trophoblasts and Maternal Leukocytes
    Susan Fisher; Fiscal Year: 2009
    ..process, semi-allogeneic fetal cells of the placenta (cytotrophoblasts;CTBs) invade the uterine lining (decidua) where they reside amongst an unusual subpopulation of maternal immune cells termed decidual granular leukocytes (..
  40. Deletion of Serglycin Proteoglycan Gene in Mice
    BARBARA SCHICK; Fiscal Year: 2005
    ..granules of all but erythroid hematopoietic cells, endothelial cells, embryonic stem cells, and murine uterine decidua during pregnancy...
  41. Regulation of Pregnancy-Dependent Adaptations
    Michael Soares; Fiscal Year: 2009
    ..Among these changes are the differentiation of uterine stromal cells into decidua and the extensive development of the associated maternal uterine vasculature...
  42. Cellular and Molecular Aspects of Implantation
    BIBHASH PARIA; Fiscal Year: 2003
    ..These results will further our understanding regarding uterine protective mechanism(s) to the safeguard of the implanting embryo during early pregnancy. ..
  43. Cellular and Molecular Aspects of Implantation
    BIBHASH PARIA; Fiscal Year: 2007
    ..These results will further our understanding regarding uterine protective mechanism(s) to the safeguard of the implanting embryo during early pregnancy. ..
  44. GLYCOCONJUGATE-INDUCED TOLERANCE IN NATURAL KILLER CELLS
    Gary Clark; Fiscal Year: 2002
    ..induction of FMT is thought to be the result of suppression of potential allogeneic responses in the uterus and decidua. The major immune cell type in the uterus that could mediate rejection is the natural killer (NK) cell, ..
  45. MECHANISM OF CELL-SPECIFIC METALLOTHIONEIN TRANSCRIPTION
    PATRICK DANIELS; Fiscal Year: 2003
    ..abstract_text> ..
  46. CELLULAR IMMUNE FACTORS IN VERTICAL TRANSMISSION OF HIV
    Christel Uittenbogaart; Fiscal Year: 2000
    ..of placentas from HIV infected pregnancies; for cytokine profiles in the trophoblast, villous stroma, and decidua; for expression of integrins and selectins that are important in cell interactions and; for HIV tropism and the ..
  47. Biology at the Maternal-Fetal Interface
    Michael Soares; Fiscal Year: 2006
    ..milieu required for the establishment and maintenance of pregnancy are largely orchestrated by two cell lineages: decidua and trophoblast. Together these highly specialized cells transiently modify the maternal compartment...
  48. MATERNAL ADAPTATIONS TO PREGNANCY
    Michael Soares; Fiscal Year: 2001
    ..and maintenance of pregnancy require the appropriate development of a specialized maternal tissue, referred to as decidua. Decidual cells arise from uterine stroma via the actions of progesterone, form intimate relationships with ..
  49. Cell Differentation During Decidualization
    Zuzana Strakova; Fiscal Year: 2010
    ..Thus, in the long term our studies might provide new targets of intervention leading to improvements in diagnosis and treatment. ..
  50. REGULATION OF CELL DIFFERENTATION DURING DECIDUALIZATION
    Zuzana Strakova; Fiscal Year: 2002
    ..We anticipate that our ongoing studies will contribute to find therapies to treat endometrial dysfunctions associated with infertility, habitual abortions and/or insufficient placental development. ..
  51. Decidua and Fetal Membranes as a Paracrine System
    Gillian Bryant Greenwood; Fiscal Year: 2006
    ..these women with PPROM and no infection, there is increased expression of the relaxin genes and proteins in the decidua and placenta...
  52. DECIDUALIZATION IN THE BABOON
    Asgerally Fazleabas; Fiscal Year: 2003
    ....
  53. A Primate Model of Maternal Fetal Immune Tolerance
    Thaddeus Golos; Fiscal Year: 2006
    ..The successful implementation of our recent adaptation of transgenic technology to the primate placenta will provide unprecedented opportunity for novel models of primate placental biology. ..
  54. Decidual-Endothelial Tissue Factor and IUGR
    Charles Lockwood; Fiscal Year: 2006
    ..Additionally, we will correlate maternal plasma levels of two sensitive thrombin markers with the presence of acquired or inherited thrombophilias in the selected patient population. ..
  55. IMMUNE ACCEPTANCE OF PREGNANCY
    Gil Mor; Fiscal Year: 2002
    ..The significance of this proposal is not limited to reproductive problems. It is anticipated that these studies will lead to a better understanding of tumor behavior, actions of chemotherapeutic agents and transplant physiology. ..
  56. UTERINE NK CELLS IN PRIMATE PREGNANCY
    Thaddeus G Golos; Fiscal Year: 2010
    ..for an important role of placental MHC class I molecules in the maternal immunological response to pregnancy in primates, and will further study the mechanisms and significance of these responses with two specific aims: ..
  57. Molecular Signaling in Decidualization
    SANJOY KUMAR DAS; Fiscal Year: 2010
    ..abstract_text> ..
  58. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2003
    ..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
  59. STRATEGIES FOR PRIMATE TRANSGENESIS
    Thaddeus Golos; Fiscal Year: 2003
    ..abstract_text> ..
  60. A PRIMATE ES CELL MODEL FOR EMBRYO IMPLANTATION
    Thaddeus Golos; Fiscal Year: 2009
    ..abstract_text> ..
  61. Dendritic cell behavior at the maternal/fetal interface
    Adrian Erlebacher; Fiscal Year: 2009
    ..fetus and placenta escape rejection during pregnancy likely involves local immune regulation within the maternal decidua, the specialized stromal tissue that surrounds the implanted embryo...
  62. ES CELL MODEL FOR PLACENTAL DEVELOPMENT
    Thaddeus Golos; Fiscal Year: 2006
    ..This proposal will allow us to develop the tools to advance a novel system for the study of primate placental biology. [unreadable] [unreadable]..
  63. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..development of the feto-placental unit is dependent on transformation of the uterine lining from endometrium to decidua. The formation of decidua is essential for normal pregnancy...