blastoderm

Summary

Summary: A single layer of cells produced by cleavage of the fertilized ovum and forming the outer cells of the blastula.

Top Publications

  1. pmc MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens
    Sang In Lee
    World Class University Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Proc Natl Acad Sci U S A 108:10426-31. 2011
  2. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
  3. pmc A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila
    Charless C Fowlkes
    Department of Computer Science, University of California Irvine, Irvine, California, USA
    PLoS Genet 7:e1002346. 2011
  4. ncbi Gene expression suggests conserved mechanisms patterning the heads of insects and myriapods
    Ralf Janssen
    Uppsala University, Department of Earth Sciences, Palaeobiology, Uppsala, Sweden
    Dev Biol 357:64-72. 2011
  5. ncbi Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node
    M Levin
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 126:4703-14. 1999
  6. ncbi The control of cell fate along the dorsal-ventral axis of the Drosophila embryo
    R P Ray
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Development 113:35-54. 1991
  7. ncbi Dynein anchors its mRNA cargo after apical transport in the Drosophila blastoderm embryo
    Renald Delanoue
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom
    Cell 122:97-106. 2005
  8. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
  9. ncbi Embryonic expression patterns of the Drosophila decapentaplegic gene: separate regulatory elements control blastoderm expression and lateral ectodermal expression
    P D Jackson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    Dev Dyn 199:28-44. 1994
  10. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006

Research Grants

  1. OOGENESIS AND EARLY EMBRYOGENESIS IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2007
  2. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2000
  3. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 1999
  4. STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1992
  5. ANALYZE STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1991
  6. ANALYZE STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1990
  7. A Morphology and Gene Expression Atlas for Drosophila Embryogenesis
    David W Knowles; Fiscal Year: 2010
  8. ACTIN-BINDING PROTEINS AND DROSOPHILA EMBRYOS
    Kathryn Miller; Fiscal Year: 1990
  9. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    JONATHAN DAVID GITLIN; Fiscal Year: 2012
  10. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    Jonathan Gitlin; Fiscal Year: 2006

Detail Information

Publications198 found, 100 shown here

  1. pmc MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens
    Sang In Lee
    World Class University Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Proc Natl Acad Sci U S A 108:10426-31. 2011
    ..Therefore, we conducted miRNA expression profiling to explore specific miRNA signatures in undifferentiated blastoderm and primordial germ cells (PGCs)...
  2. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
    The variation in the expression patterns of the gap genes in the blastoderm of the fruit fly Drosophila melanogaster reduces over time as a result of cross regulation between these genes, a fact that we have demonstrated in an ..
  3. pmc A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila
    Charless C Fowlkes
    Department of Computer Science, University of California Irvine, Irvine, California, USA
    PLoS Genet 7:e1002346. 2011
    ..To assess the scope of such changes, we used high-resolution imaging methods to measure mRNA expression in blastoderm embryos of Drosophila yakuba and Drosophila pseudoobscura and assembled these data into cellular resolution ..
  4. ncbi Gene expression suggests conserved mechanisms patterning the heads of insects and myriapods
    Ralf Janssen
    Uppsala University, Department of Earth Sciences, Palaeobiology, Uppsala, Sweden
    Dev Biol 357:64-72. 2011
    ..But different from the situation in most arthropods in this species all segments are formed from the early blastoderm (so called long-germ developmental mode)...
  5. ncbi Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node
    M Levin
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 126:4703-14. 1999
    ..that indicate that the initiation of these programs requires communication between the two sides of the blastoderm. When deprived of either the left or the right lateral halves of the blastoderm, embryos are incapable of ..
  6. ncbi The control of cell fate along the dorsal-ventral axis of the Drosophila embryo
    R P Ray
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Development 113:35-54. 1991
    ..Two of the genes, dpp and twi, are unaffected by mutations in any of the tested zygotic dorsal-ventral genes, suggesting that dpp and twi are the primary patterning genes for dorsal ectoderm and mesoderm, respectively...
  7. ncbi Dynein anchors its mRNA cargo after apical transport in the Drosophila blastoderm embryo
    Renald Delanoue
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom
    Cell 122:97-106. 2005
    ..Here, we use a new RNA anchoring assay in living Drosophila blastoderm embryos to show that apical anchoring of mRNA after completion of dynein transport does not depend on actin or ..
  8. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We describe a registration technique that takes image-based data from hundreds of Drosophila blastoderm embryos, each costained for a reference gene and one of a set of genes of interest, and builds a model ..
  9. ncbi Embryonic expression patterns of the Drosophila decapentaplegic gene: separate regulatory elements control blastoderm expression and lateral ectodermal expression
    P D Jackson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    Dev Dyn 199:28-44. 1994
    ..indistinguishable from the patterns of endogenous dpp expression in the dorsal and terminal cells at the blastoderm stage, in the dorsal ectoderm during germ band elongation, and in narrow stripes of ectodermal cells along the ..
  10. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  11. pmc Mechanisms of gap gene expression canalization in the Drosophila blastoderm
    Vitaly V Gursky
    Theoretical Department, Ioffe Physical Technical Institute of the Russian Academy of Sciences, St, Petersburg, 194021 Russia
    BMC Syst Biol 5:118. 2011
    Extensive variation in early gap gene expression in the Drosophila blastoderm is reduced over time because of gap gene cross regulation...
  12. pmc Mutations of the Drosophila zinc finger-encoding gene vielfältig impair mitotic cell divisions and cause improper chromosome segregation
    Nicole Staudt
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, 37077 Gottingen, Germany
    Mol Biol Cell 17:2356-65. 2006
    ..Loss of vfl activity disrupts the pattern of mitotic waves in preblastoderm embryos, elicits asynchronous DNA replication, and causes improper chromosome segregation during mitosis...
  13. pmc Dynamic reprogramming of chromatin accessibility during Drosophila embryo development
    Sean Thomas
    Department of Genome Sciences, University of Washington, Foege S310A, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 12:R43. 2011
    ..Understanding the scope and features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of developmental biology...
  14. ncbi A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
    S Roth
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Federal Republic of Germany
    Cell 59:1189-202. 1989
    ..A correlation between dl protein distribution and embryonic pattern in mutant embryos indicates that the nuclear concentration of the dl protein determines pattern along the dorsoventral axis...
  15. ncbi Identical transacting factor requirement for knirps and knirps-related Gene expression in the anterior but not in the posterior region of the Drosophila embryo
    M Rothe
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 46:169-81. 1994
    ..Both genes are initially expressed in three identical regions of the blastoderm embryo: in an anterior cap domain, in an anterior stripe and in a posterior broad band linked to the kni gap ..
  16. pmc cis-acting control elements for Krüppel expression in the Drosophila embryo
    M Hoch
    Institut für Genetik und Mikrobiologie der Universität München, FRG
    EMBO J 9:2587-95. 1990
    ..More than one cis-regulatory element drives the expression in the anterior domain at the blastoderm stage, in the nervous system, the midline precursor cells and in the amino-serosa...
  17. pmc The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
    Hsiao Lan Liang
    Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nature 456:400-3. 2008
    ..Mutant embryos lacking zld are defective in cellular blastoderm formation, and fail to activate many genes essential for cellularization, sex determination and pattern ..
  18. ncbi Evidence that MSL-mediated dosage compensation in Drosophila begins at blastoderm
    A Franke
    Department of Biological Sciences, Stanford University, CA 94305, USA
    Development 122:2751-60. 1996
    ..we report experiments that show that the MSL proteins first associate with the male X chromosome as early as blastoderm stage, slightly earlier than the histone H4 isoform acetylated at lysine 16 is detected on the X chromosome...
  19. ncbi The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development
    R Finkelstein
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Nature 346:485-8. 1990
    ..We also show that otd expression responds to the activity of the maternal tor gene at the anterior pole of the embryo...
  20. ncbi Acute and long-term effects after single loading of functionalized multi-walled carbon nanotubes into zebrafish (Danio rerio)
    Jinping Cheng
    Department of Biology and Chemistry, City University of Hong Kong, Hong Kong
    Toxicol Appl Pharmacol 235:216-25. 2009
    ..The injected FITC-BSA-MWCNTs (at 1-cell stage) were allocated to all blastoderm cells of the embryos through proliferation, and were distinctively excluded from the yolk cell...
  21. ncbi Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis
    V E Foe
    J Cell Sci 61:31-70. 1983
    ..from stage 10 through 14 of Drosophila embryogenesis, that is just prior to and during formation of the cellular blastoderm. We have supplemented these studies with data collected from fixed, stained, whole embryos...
  22. ncbi Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo
    Osamu Shimmi
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell 120:873-86. 2005
    Patterning the dorsal surface of the Drosophila blastoderm embryo requires Decapentaplegic (Dpp) and Screw (Scw), two BMP family members...
  23. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ..initiate anterior/posterior patterning in Drosophila bind to overlapping sets of thousands of genomic regions in blastoderm embryos...
  24. doi Huckebein is part of a combinatorial repression code in the anterior blastoderm
    Luiz Paulo Andrioli
    Departamento de Genética e Biologia Evolutiva, Instituto de Biociencias, Universidade Sao Paulo, R do Matão, 277, Cidade Universitaria, 05508 000, Sao Paulo, SP, Brazil
    Dev Biol 361:177-85. 2012
    ....
  25. pmc Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm
    Peggy P Vorwald-Denholtz
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, United States
    Gene Expr Patterns 11:456-63. 2011
    ..It was found that the posterior band of Wg is first detected in blastoderm at mid nuclear cycle 14, before the segment-polarity stripes of Wg are formed in other segments...
  26. doi Nodal signal is required for morphogenetic movements of epiblast layer in the pre-streak chick blastoderm
    Nariaki Yanagawa
    Department of Anatomy and Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Dev Growth Differ 53:366-77. 2011
    ..In cultured posterior blastoderm explants from stage X to XI embryos, either Lefty1 or Cerberus-S inhibited initial migration of the explants on ..
  27. pmc Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly
    Matt A Futterman
    Woodruff School of Mechanical Engineering, Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Dev Dyn 240:1502-11. 2011
    ..of epithelial-to-mesenchymal transition (EMT) in the inner zone of the extraembryonic Area Opaca and at the blastoderm edge...
  28. ncbi Expression and sequence analysis of the Drosophila blastoderm-specific gene bsg25A
    J B Singer
    University of California, Los Angeles, Department of Molecular, Cell and Developmental Biology 90095 1606, USA
    Gene 197:379-82. 1997
    By differential screening of a genomic library, we have cloned a gene expressed specifically during the blastoderm stage of Drosophila embryogenesis...
  29. ncbi bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo
    E D Schejter
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cell 75:373-85. 1993
    ..bnk, whose expression is restricted to the blastoderm stages of Drosophila embryogenesis, encodes a novel, exceptionally basic protein that specifically colocalizes ..
  30. ncbi Invasion by matrix metalloproteinase-expressing cells is important for primitive streak formation in early chick blastoderm
    Kazue Mogi
    Research Institute for Integrated Sciences, Kanagawa University, Hiratsuka, Japan
    Cells Tissues Organs 192:1-16. 2010
    ..These results suggest that MMPs are involved in the enzymatic degradation of the basement membrane underlying the epiblast and are thus important for the ingression of mesendodermal cells along the primitive streak...
  31. pmc Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm
    Xiao Yong Li
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Biol 6:e27. 2008
    ..with quantitatively different specificities to highly overlapping sets of several thousand genomic regions in blastoderm embryos...
  32. ncbi Centriole and centrosome dynamics during the embryonic cell cycles that follow the formation of the cellular blastoderm in Drosophila
    G Callaini
    Department of Evolutionary Biology, University of Siena, Italy
    Exp Cell Res 234:183-90. 1997
    ..This "immature" centriolar morphology was shown to persist throughout embryonic development, clearly demonstrating that these centrioles are able to replicate despite their apparently neotenic structure...
  33. ncbi The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos
    M A Postner
    Department of Molecular Biology, Princeton University, NJ 08544
    J Cell Sci 107:1863-73. 1994
    ..Mutant embryos demonstrate that neither protein translationally regulates the other, but the localization of the sry-alpha protein to the hexagonal network is dependent upon nullo...
  34. pmc Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability
    Chi F Lee
    Department of Biology and the Molecular Biology Institute, San Diego State University, San Diego, CA 92182, USA
    J Cell Sci 124:699-705. 2011
    ..It colocalizes with non-muscle myosin in embryonic blastoderm of 2-hour-old embryos...
  35. ncbi even-skipped is not a pair-rule gene but has segmental and gap-like functions in Oncopeltus fasciatus, an intermediate germband insect
    Paul Z Liu
    Department of Biology, Indiana University, 1001 East Third Street, Bloomington, IN 47405, USA
    Development 132:2081-92. 2005
    ..Given the large RNAi deletion phenotype and its regulation of hunchback and Krüppel, even-skipped seems to act as an über-gap gene in Oncopeltus, indicating that it may have both upstream and downstream roles in segmentation...
  36. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics
    Soile V E Keränen
    Berkeley Drosophila Transcription Network Project, Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA
    Genome Biol 7:R124. 2006
    ..To accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos...
  37. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..of integrated data is very close to the expression profiles of individual embryos during the latter part of the blastoderm stage...
  38. doi Bicoid occurrence and Bicoid-dependent hunchback regulation in lower cyclorrhaphan flies
    Steffen Lemke
    University of Chicago, Department of Organismal Biology and Anatomy, CLSC 921B, 920 E 58th Street, Chicago, IL 60637, USA
    Evol Dev 10:413-20. 2008
    ..hunchback is activated by Bicoid throughout the anterior half of the blastoderm and a Bicoid-binding cis-regulatory element has been identified immediately upstream of the proximal hunchback ..
  39. ncbi How one becomes many: blastoderm cellularization in Drosophila melanogaster
    Aveek Mazumdar
    National Center for Biological Sciences, Tata Institute of Fundamental Research, GKVK Campus, Bangalore, India
    Bioessays 24:1012-22. 2002
    ..nuclear divisions, unaccompanied by cytokinesis, to produce a multi-nucleated single cell embryo, the syncytial blastoderm. The syncytium then undergoes a process of cell formation, in which the individual nuclei become enclosed in ..
  40. ncbi The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription
    John R ten Bosch
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3204, USA
    Development 133:1967-77. 2006
    ..The DNA sequence CAGGTAG had been implicated in this pre-cellular blastoderm activation of sex-determination genes...
  41. pmc A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm
    Elena M Lucchetta
    Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA
    PLoS ONE 3:e3651. 2008
    ..by diffusion and initiates expression of target genes in a concentration-dependent manner in the syncytial blastoderm. Recent work has emphasized the stability of the Bicoid gradient as a function of egg length and the role of ..
  42. ncbi Mutual regulatory interactions of the trunk gap genes during blastoderm patterning in the hemipteran Oncopeltus fasciatus
    Jonathan Ben-David
    Dept of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    Dev Biol 346:140-9. 2010
    The early embryo of the milkweed bug, Oncopeltus fasciatus, appears as a single cell layer - the embryonic blastoderm - covering the entire egg...
  43. pmc Estimation of errors introduced by confocal imaging into the data on segmentation gene expression in Drosophila
    Ekaterina Myasnikova
    St Petersburg State Polytechnic University, St Petersburg, 195251, Russia
    Bioinformatics 25:346-52. 2009
    ..Following this approach, we generated a large dataset on the expression of segmentation genes in the Drosophila blastoderm, that is widely used in systems biology studies...
  44. ncbi Regulatory and coding regions of the segmentation gene hunchback are functionally conserved between Drosophila virilis and Drosophila melanogaster
    W Lukowitz
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, Germany
    Mech Dev 45:105-15. 1994
    ..of hb in the early embryo, namely the enhancer for the maternal expression and the enhancer region for the late blastoderm expression...
  45. ncbi Apical localization of pair-rule transcripts requires 3' sequences and limits protein diffusion in the Drosophila blastoderm embryo
    I Davis
    ICRF Developmental Biology Unit, Zoology Department, Oxford, England
    Cell 67:927-40. 1991
    The peripheral cytoplasm (periplasm) of the Drosophila blastoderm embryo is subdivided into apical and basal compartments by a layer of nuclei...
  46. pmc Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster
    CECELIA M MILES
    The University of Chicago, Department of Ecology and Evolution, 1101 E 57 St, Chicago, Illinois 60637, USA
    Evolution 65:33-42. 2011
    ..The number of nuclei at the cellular blastoderm stage also changed in response to selection, with large-egg selected lines having more than 1000 additional ..
  47. pmc Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Biol 7:e1000049. 2009
    ..quantitative gene expression data have become available for the segment determination process in the Drosophila blastoderm, revealing a specific instance of canalization...
  48. ncbi Sp1/egr-like zinc-finger protein required for endoderm specification and germ-layer formation in Drosophila
    G Bronner
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Nature 369:664-8. 1994
    ..huckebein (hkb), a member of the gap-gene class of segmentation genes, is required for germ-layer formation at blastoderm. Absence of the hkb product, an Sp1/egr-like zinc-finger protein, causes the ectodermal and mesodermal primordia ..
  49. doi Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions
    Gang Zhang
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    J Cell Sci 122:535-45. 2009
    ..We propose that Mars is an important linker between the spindle and the centrosomes that is required for proper spindle organization during the rapid mitotic cycles in early embryogenesis...
  50. ncbi vasa mRNA accumulates at the posterior pole during blastoderm formation in the flour beetle Tribolium castaneum
    Reinhard Schröder
    Interfakultäres Institut für Zellbiologie, Abt Genetik der Tiere, Auf der Morgenstelle 28, D 72076, Tubingen, Germany
    Dev Genes Evol 216:277-83. 2006
    ..is ubiquitously distributed in the egg, Tc-vasa mRNA gradually accumulates at the posterior egg pole during blastoderm formation...
  51. ncbi A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
    P M Macdonald
    Nature 324:537-45. 1986
    ..Mutations in the cad gene that reduce or eliminate the gradient cause abnormal zygotic expression of at least one segmentation gene (fushi tarazu) and alter the global body pattern...
  52. ncbi Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo
    J Mohler
    Department of Biological Sciences, Barnard College, New York, NY 10027, USA
    Mech Dev 50:151-61. 1995
    ..otd, ems and btd) on the spatial expression of the segment polarity genes, wg and hh, were analyzed at the late blastoderm stage and during subsequent development...
  53. ncbi Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages
    Y Emori
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    J Biol Chem 269:19474-9. 1994
    ..by whole amount in situ hybridization, revealed that the mRNA emerges and reaches maximum levels at the cellular blastoderm stage and then decreases rapidly to a lower level...
  54. ncbi A maternal product of the Punch locus of Drosophila melanogaster is required for precellular blastoderm nuclear divisions
    X Chen
    Department of Biological Sciences, University of Alabama, Tuscaloosa 35487
    J Cell Sci 107:3501-13. 1994
    ..We demonstrate here that the embryos exhibit nuclear division defects during the precellular blastoderm stage of development...
  55. ncbi Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila
    Jennifer A Stein
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute at NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 129:3925-34. 2002
    ..Removal of both zygotic and maternal slam results in an earlier defect: a failure to form a cellular blastoderm. Consistent with this phenotype, we found that slam is one of the earliest genes to be transcribed in the embryo,..
  56. ncbi Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila
    A Vincent
    Department of Molecular Biology, Princeton University, New Jersey 08540, USA
    Development 124:3747-54. 1997
    ....
  57. doi Early embryonic development in the spider Achaearanea tepidariorum: Microinjection verifies that cellularization is complete before the blastoderm stage
    Masaki Kanayama
    JT Biohistory Research Hall, 1 1 Murasaki cho, Takatsuki, Osaka, Japan
    Arthropod Struct Dev 39:436-45. 2010
    ..Furthermore, these data imply that in contrast to the Drosophila syncytial blastoderm embryo, the cell-based structure of the Achaearanea blastoderm embryo restricts diffusion of cytoplasmic gene ..
  58. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..btd is expressed in the syncytial blastoderm embryo in a stripe covering the anlagen of the antennal, intercalary and mandibular head segments...
  59. pmc The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei
    David Frescas
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 173:219-30. 2006
    ..The nuclear-associated units of ER and Golgi across the syncytial blastoderm produced secretory products that were delivered to the plasma membrane in a spatially restricted fashion across ..
  60. ncbi Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryos
    V E Foe
    Department of Zoology, University of Washington, Seattle WA 98195 1800, USA
    Development 127:1767-87. 2000
    ..We analogize pseudocleavage furrow formation in the Drosophila blastoderm with how the mitotic apparatus positions the cleavage furrow for standard cytokinesis, and relate our findings ..
  61. ncbi Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development
    F Janody
    LGPD, IBDM, Parc Scientifique de Luminy, Case 907, Marseille, France
    Development 127:1573-82. 2000
    ..is controlled by several zygotic genes that are positively regulated at the anterior pole of Drosophila blastoderm embryos by the anterior (bicoid) and the terminal (torso) maternal determinants...
  62. pmc Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients
    M Fujioka
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 126:2527-38. 1999
    ..Most of these patterns are driven by non-overlapping regulatory elements, including ones for syncytial blastoderm stage stripes 1 and 5, while a single element specifies both stripes 4 and 6...
  63. ncbi Multiple isoforms of the Drosophila Spätzle protein are encoded by alternatively spliced maternal mRNAs in the precellular blastoderm embryo
    Y DeLotto
    Department of Genetics, University of Copenhagen, Denmark
    Mol Gen Genet 264:643-52. 2001
    ..gene encodes at least ten different protein isoforms as a result of complex alternative splicing in precellular blastoderm embryos...
  64. ncbi Dynamic control of positional information in the early Drosophila embryo
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Nature 430:368-71. 2004
    ..of maternal morphogen concentration is not sufficient to determine shifting gap domain boundary positions, and suggests that establishing and interpreting positional information are not independent processes in the Drosophila blastoderm.
  65. ncbi Kruppel is a gap gene in the intermediate germband insect Oncopeltus fasciatus and is required for development of both blastoderm and germband-derived segments
    Paul Z Liu
    Department of Biology, Indiana University, 1001 East Third Street, Bloomington IN, 47405, USA
    Development 131:4567-79. 2004
    ..A cascade of segmentation genes patterns the embryo along its anterior-posterior axis via subdivision of the blastoderm. This is in contrast to short and intermediate germband modes of segmentation where the anterior segments are ..
  66. pmc Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Genetics 167:1721-37. 2004
    ..Finally, our models suggest a correlation between timing of gap domain boundary formation and regulatory contributions from the terminal maternal system...
  67. ncbi Origin, fate, and function of the components of the avian germ disc region and early blastoderm: role of ooplasmic determinants
    Marc Callebaut
    University of Antwerp, Laboratory of Human Anatomy and Embryology, Groenenborgerlaan 171, BE 2020 Antwerpen, Belgium
    Dev Dyn 233:1194-216. 2005
    ..and delta ooplasms occurs so that gamma and delta ooplasms become incorporated into the deeper part of the avian blastoderm. These ooplasms seem to contain ooplasmic determinants that initiate either early neurulation or gastrulation ..
  68. pmc Dynactin suppresses the retrograde movement of apically localized mRNA in Drosophila blastoderm embryos
    Georgia Vendra
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    RNA 13:1860-7. 2007
    ..Apical transport and anchoring of wingless and pair-rule transcripts in the Drosophila syncytial blastoderm embryo is mediated by cytoplasmic Dynein, the major minus end directed microtubule dependent molecular motor...
  69. pmc Onset of the DNA replication checkpoint in the early Drosophila embryo
    Justin Crest
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    Genetics 175:567-84. 2007
    ..embryo inversely correlates with the ability to lengthen interphase as the embryo transits from preblastoderm to blastoderm stages and defines the onset of a checkpoint that regulates mitosis when DNA replication is blocked with ..
  70. ncbi Germ-line chimera by lower-part blastoderm transplantation between diploid goldfish and triploid crucian carp
    E Yamaha
    Nanae Fresh Water Laboratory, Field Science Center for Northern Biosphere, Hokkaido University, Kameda, Japan
    Genetica 111:227-36. 2001
    Germ-line chimerism was successfully induced by blastoderm transplantation from donor triploid crucian carp, which reproduces gynogenetically, to recipient diploid goldfish, which reproduces bisexually...
  71. ncbi Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped
    P W Ingham
    Imperial Cancer Research Fund, Department of Zoology, Oxford, UK
    Nature 331:73-5. 1988
    During the late cellular blastoderm stage of Drosophila embryo-genesis the segmentation genes engrailed, en, and wingless, wg, become expressed in two series of 14 stripes which will subsequently coincide with the anterior and posterior ..
  72. ncbi Regulation and function of the terminal gap gene huckebein in the Drosophila blastoderm
    G Bronner
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Int J Dev Biol 40:157-65. 1996
    ..formation in Drosophila involves a cascade of maternal and zygotic factors which are spatially restricted in the blastoderm embryo...
  73. ncbi Cytoarchitecture and the patterning of fushi tarazu expression in the Drosophila blastoderm
    B A Edgar
    Department of Genetics, University of Washington, Seattle 98195
    Genes Dev 1:1226-37. 1987
    In the Drosophila embryo at the blastoderm stage, the segmentation gene fushi tarazu (ftz) is expressed in a seven-banded pattern...
  74. ncbi The zygotic segmentation mutant tailless alters the blastoderm fate map of the Drosophila embryo
    P A Mahoney
    Dev Biol 122:464-70. 1987
    ..to a reprogramming of the blastoderm fate map, we hybridized probes for the segmentation genes fushi tarazu (ftz) and hairy (h) to whole embryos...
  75. ncbi Two gap genes mediate maternal terminal pattern information in Drosophila
    D Weigel
    Universitat Munchen, Institut fur Genetik und Mikrobiologie, Federal Republic of Germany
    Science 248:495-8. 1990
    ..The activities of tailless (tll) and the newly identified gap gene huckebein (hkb) are specifically involved in mediating the maternal terminal information at the posterior end of the blastoderm embryo.
  76. ncbi The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system
    M A Kania
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 4:1701-13. 1990
    ..Experiments with the runt antibody also indicated that the protein is present throughout embryogenesis and is expressed extensively in the developing central and peripheral nervous system...
  77. pmc Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos
    B Thisse
    Unité 184 de Biologie Moléculaire, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    EMBO J 7:2175-83. 1988
    ..It is present over both poles and in the midventral region (endoderm and mesoderm anlagen) at cellular blastoderm stage; later in development, it is detected within the mesodermal layer until its differentiation into ..
  78. ncbi The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm
    J C Izpisua-Belmonte
    Molecular Biology Institute, University of California, Los Angeles 90024 1737
    Cell 74:645-59. 1993
    ..We propose that development of the chick organizer starts earlier than previously thought and that gsc marks this changing cell population...
  79. ncbi Localization of the fushi tarazu protein during Drosophila embryogenesis
    S B Carroll
    Cell 43:47-57. 1985
    ..coli. The ftz protein was first detectable in blastoderm-stage embryos as seven stripes of nuclei encircling the embryos transversely...
  80. pmc Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex
    C M Field
    Department of Biochemistry and Biophysics, University of California, San Francisco Medical Center 94143 0448, USA
    J Cell Biol 131:165-78. 1995
    ..We speculate that anillin plays a role in organizing and/or stabilizing the cleavage furrow and other cell cycle regulated, contractile domains of the actin cytoskeleton...
  81. ncbi Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos
    J Walter
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520
    Genes Dev 8:1678-92. 1994
    ..We propose that these data favor the model that eve, ftz, and closely related homeo domain proteins act by directly regulating mostly the same target genes...
  82. pmc armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila
    H A Muller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    J Cell Biol 134:149-63. 1996
    ..These results suggest that early stages in the assembly of the ZA are critical for the stability of the polarized blastoderm epithelium.
  83. ncbi Activation of posterior gap gene expression in the Drosophila blastoderm
    R Rivera-Pomar
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Nature 376:253-6. 1995
    The process of body prepatterning during Drosophila blastoderm formation relies on the localized activities of zygotic segmentation genes, which are controlled by asymmetrically distributed maternal determinants...
  84. ncbi Non-periodic cues generate seven ftz stripes in the Drosophila embryo
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 50:163-75. 1995
    ..This multi-level regulation provides a back-up system that ensures the development of seven stripes in the blastoderm.
  85. ncbi Drop out: a third chromosome maternal-effect locus required for formation of the Drosophila cellular blastoderm
    S Galewsky
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Reprod Dev 32:331-8. 1992
    ..Phenotypic analyses of the dop mutation indicate that the gene is required for proper formation of the cellular blastoderm. In embryos derived from either homozygous or hemizygous dop mothers, cytoplasmic clearing, nuclear migration ..
  86. pmc DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo
    Mojgan Padash Barmchi
    Department of Cell and Molecular Biology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, 22184 Lund, Sweden
    J Cell Biol 168:575-85. 2005
    ..and actomyosin contractility during nuclear divisions, pole cell formation, and cellularization of syncytial blastoderm embryos...
  87. ncbi The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respond to the nucleocytoplasmic ratio
    L S Rose
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Genes Dev 6:1255-68. 1992
    ..The regulation of nullo RNA levels during cycle 14, however, is coupled to the nucleocytoplasmic ratio, which also controls the cessation of rapid, synchronous mitosis just before cellularization...
  88. ncbi A two-step mode of stripe formation in the Drosophila blastoderm requires interactions among primary pair rule genes
    C Hartmann
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 45:3-13. 1994
    The stripe pattern of pair rule gene expression along the anterior-posterior axis of the Drosophila blastoderm embryo represents the first sign of periodicity during the process of segmentation...
  89. pmc Isolation and characterization of a Drosophila gene essential for early embryonic development and formation of cortical cleavage furrows
    C X Zhang
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biol 134:923-34. 1996
    ..melanogaster, which arrests the embryonic development during the transition from syncytial to cellular blastoderm. Cytological analysis of the mutant embryos indicates that pseudocleavage furrows in the syncytial blastoderm ..
  90. ncbi Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm
    Tetsuhiro Kudoh
    Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
    Development 129:4335-46. 2002
    ..Cyp26 is first expressed in the presumptive anterior neural ectoderm and the blastoderm margin at the late blastula...
  91. ncbi The germ cell lineage identified by vas-mRNA during the embryogenesis in goldfish
    Satoshi Otani
    Laboratory of Breeding Science, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Japan
    Zoolog Sci 19:519-26. 2002
    ..These signals were inherited to the primordial germ cells, suggesting that vas-positive cells were primordial germ cells (PGCs) in goldfish...
  92. ncbi Utilization of central disk of blastoderm and germinal crescent region for production of interspecific germline chimera between chicken and quail
    Tomoki Soh
    Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812 8581, Japan
    Asian J Androl 4:83-6. 2002
    ..The production of interspecific germline chimeras between chicken and quail were attempted employing the dissociated cells derived from the blastodermal central disk (stage X) and the germinal crescent region of embryo (stage 7-8)...
  93. ncbi In the absence of Rauber's sickle material, no blood islands are formed in the avian blastoderm
    Marc Callebaut
    Laboratory of Human Anatomy and Embryology UA RUCA, B 2020 Antwerpen, Belgium
    J Morphol 253:132-47. 2002
    ..for approximately 2 days): after removal of the autochthonous Rauber's sickle from an unincubated chicken blastoderm, a quail Rauber's sickle was grafted isotopically and isochronically in its place...
  94. ncbi Tribolium mae expression suggests roles in terminal and midline patterning and in the specification of mesoderm
    Gregor Bucher
    Institut fur Zoologie, Friedrich Alexander Universität Erlangen, Staudtstrasse 5, 91058, Erlangen, Germany
    Dev Genes Evol 215:478-81. 2005
    ..the red flour beetle Tribolium castaneum (Tc'mae) is active at the posterior, but not the anterior pole of the blastoderm. Since MAPK signaling is known to be active at both poles, Tc'Mae could function to modulate terminal MAPK ..
  95. pmc Evolutionary origin of the amnioserosa in cyclorrhaphan flies correlates with spatial and temporal expression changes of zen
    Ab Matteen Rafiqi
    Department of Organismal Biology and Anatomy, University of Chicago, Cummings Life Science Center 921B, 920 East 58th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:234-9. 2008
    ....
  96. ncbi Research of blastocyte-like structure in chicken
    Jia Li
    College of Animal Science and Technology, China Agricultural University, Beijing 100094, China
    Sci China C Life Sci 48:481-6. 2005
    ..So we drew the conclusion that the BLS obtained from broken blastoderm can be used to amplify avian ES cells so as to initiate a new method of producing transgenic chickens.
  97. pmc Drosophila mode of metamerization in the embryogenesis of the lepidopteran insect Manduca sexta
    R Kraft
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Gottingen, Germany
    Proc Natl Acad Sci U S A 91:6634-8. 1994
    ..orthologues of Drosophila segmentation genes from the tobacco hawkmoth Manduca sexta and have found that the blastoderm expression patterns of these genes show a molecular prepatterning typical of Drosophila...
  98. ncbi RNAi-mediated inhibition of gene function in the follicle cell layer of the Drosophila ovary
    Xianjun Zhu
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Genesis 40:101-8. 2004
    ..These results stress the importance of careful choice of expression system and of conditions for use in transgenic RNAi-mediated studies of gene function...
  99. ncbi Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man
    S D Zhang
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Genes Dev 10:1108-19. 1996
    ..During embryogenesis, Plx uniformly covers the apical surface of cellular blastoderm cells...
  100. ncbi src64 and tec29 are required for microfilament contraction during Drosophila cellularization
    Jeffrey H Thomas
    Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Development 131:863-71. 2004
    Formation of the Drosophila cellular blastoderm involves both membrane invagination and cytoskeletal regulation...
  101. ncbi Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution
    Simon L Bullock
    Cancer Research UK, Developmental Genetics Laboratory, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 131:4251-61. 2004
    Establishment of segmental pattern in the Drosophila syncytial blastoderm embryo depends on pair-rule transcriptional regulators...

Research Grants71

  1. OOGENESIS AND EARLY EMBRYOGENESIS IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2007
    ..14 in Drosophila is characterized by morphological changes that transform the syncytial embryo into a cellular blastoderm, and then into a gastrula with defined cell types organized in a three dimensional pattern...
  2. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2000
    ..The studies will concentrate on bridging the gap between the expression pattern of segmentation genes at the blastoderm stage and the final pattern of cell differentiation in the epidermis...
  3. SEGMENTATION AND PATTERNING IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 1999
    ..The studies will concentrate on bridging the gap between the expression pattern of segmentation genes at the blastoderm stage and the final pattern of cell differentiation in the epidermis...
  4. STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1992
    The blastoderm stage in Drosophila melanogaster is a time of cell determination and dramatic transitions in the cell cycle and in transcription...
  5. ANALYZE STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1991
    The blastoderm stage in Drosophila melanogaster is a time of cell determination and dramatic transitions in the cell cycle and in transcription...
  6. ANALYZE STEPS CONTROLLING GENE EXPRESSION
    JUDITH LENGYEL; Fiscal Year: 1990
    The blastoderm stage in Drosophila melanogaster is a time of cell determination and dramatic transitions in the cell cycle and in transcription...
  7. A Morphology and Gene Expression Atlas for Drosophila Embryogenesis
    David W Knowles; Fiscal Year: 2010
    ..The early stage blastoderm embryos analyzed in these initial studies, however, have a relatively simple structure that is comprised of a ..
  8. ACTIN-BINDING PROTEINS AND DROSOPHILA EMBRYOS
    Kathryn Miller; Fiscal Year: 1990
    ..insight into the actin-mediated process that contribute to the formation of a properly organized cellular blastoderm as a substrate of differentiation...
  9. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    JONATHAN DAVID GITLIN; Fiscal Year: 2012
    ..following treatment of embryos with a small molecule that interferes with copper delivery to the developing blastoderm. Specific genes involved in copper homeostasis and function that are critical for prenatal development will be ..
  10. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    Jonathan Gitlin; Fiscal Year: 2006
    ..following treatment of embryos with a small molecule that interferes with copper delivery to the developing blastoderm. Specific genes involved in copper homeostasis and function that are critical for prenatal development will be ..
  11. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    JONATHAN DAVID GITLIN; Fiscal Year: 2010
    ..following treatment of embryos with a small molecule that interferes with copper delivery to the developing blastoderm. Specific genes involved in copper homeostasis and function that are critical for prenatal development will be ..
  12. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    Jonathan Gitlin; Fiscal Year: 2009
    ..following treatment of embryos with a small molecule that interferes with copper delivery to the developing blastoderm. Specific genes involved in copper homeostasis and function that are critical for prenatal development will be ..
  13. BIOLOGICAL ROLES OF COPPER IN HUMAN NUTRITION
    Jonathan Gitlin; Fiscal Year: 2007
    ..following treatment of embryos with a small molecule that interferes with copper delivery to the developing blastoderm. Specific genes involved in copper homeostasis and function that are critical for prenatal development will be ..
  14. FORMATION, STRUCTURE AND FUNCTION IN HETEROCHROMATIN
    Sarah Elgin; Fiscal Year: 1990
    ..Heterochromatin is absent from early cleavage nuclei in Drosophila, but present by the cellular blastoderm stage...
  15. FORMATION, STRUCTURE AND FUNCTION IN HETEROCHROMATIN
    Sarah Elgin; Fiscal Year: 1991
    ..Heterochromatin is absent from early cleavage nuclei in Drosophila, but present by the cellular blastoderm stage...
  16. FORMATION, STRUCTURE AND FUNCTION IN HETEROCHROMATIN
    Sarah Elgin; Fiscal Year: 1992
    ..Heterochromatin is absent from early cleavage nuclei in Drosophila, but present by the cellular blastoderm stage...
  17. RESEARCH ON NEURULATION
    GARY SCHOENWOLF; Fiscal Year: 1993
    ..The proposed project has three specific aims: 1) to construct prospective fate maps of the avian blastoderm at stages preceding formation of the definitive neural plate, to examine the relative (and perhaps spatially and ..
  18. ESTABLISHMENT OF DPP ACTIVITY GRADIENT IN DROSOPHILA
    EDWIN FERGUSON; Fiscal Year: 2004
    ..Visualization of secreted, reinternalized Dpp protein indicates that during late blastoderm stage Dpp becomes concentrated in the dorsal 10% of cells by a process of directional diffusion through the ..
  19. ESTABLISHMENT OF DPP ACTIVITY GRADIENT IN DROSOPHILA
    EDWIN FERGUSON; Fiscal Year: 2005
    ..Visualization of secreted, reinternalized Dpp protein indicates that during late blastoderm stage Dpp becomes concentrated in the dorsal 10% of cells by a process of directional diffusion through the ..
  20. ESTABLISHMENT OF DPP ACTIVITY GRADIENT IN DROSOPHILA
    EDWIN FERGUSON; Fiscal Year: 2006
    ..Visualization of secreted, reinternalized Dpp protein indicates that during late blastoderm stage Dpp becomes concentrated in the dorsal 10% of cells by a process of directional diffusion through the ..
  21. ESTABLISHMENT OF DPP ACTIVITY GRADIENT IN DROSOPHILA
    EDWIN FERGUSON; Fiscal Year: 2007
    ..Visualization of secreted, reinternalized Dpp protein indicates that during late blastoderm stage Dpp becomes concentrated in the dorsal 10% of cells by a process of directional diffusion through the ..
  22. OOGENESIS AND EARLY EMBRYOGENESIS IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2006
    ..14 in Drosophila is characterized by morphological changes that transform the syncytial embryo into a cellular blastoderm, and then into a gastrula with defined cell types organized in a three dimensional pattern...
  23. OOGENESIS AND EARLY EMBRYOGENESIS IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 2009
    ..14 in Drosophila is characterized by morphological changes that transform the syncytial embryo into a cellular blastoderm, and then into a gastrula with defined cell types organized in a three dimensional pattern...
  24. OOGENESIS AND EARLY EMBRYOGENESIS IN DROSOPHILA
    Eric F Wieschaus; Fiscal Year: 2010
    ..14 in Drosophila is characterized by morphological changes that transform the syncytial embryo into a cellular blastoderm, and then into a gastrula with defined cell types organized in a three dimensional pattern...
  25. REGULATION OF THE BITHORAX COMPLEX
    Michael O Connor; Fiscal Year: 1992
    ..gene products to initiate transcription of BX-C gene expression within precise spatial domains at the blastoderm stage of embryogenesis...
  26. MECHANISMS FOR SEX DETERMINATION IN GERM CELLS
    ANTHONY MAHOWALD; Fiscal Year: 1993
    ..Recently, however, ovo has been shown to be active in a sex-specific manner as early as the blastoderm stage and that mutations in ovo cause a switch in differentiation into the male germ line pathway...
  27. RECOMBINANT ANTIBODIES FOR INFANT PROTECTION
    Sherie Morrison; Fiscal Year: 1999
    ..Vectors tested for Ig expression using chicken lymphoid cell lines will be transfected into Stage X blastoderm cells and these transfected cells used to make chimeric embryos...
  28. MECHANISMS FOR SEX DETERMINATION IN GERM CELLS
    ANTHONY MAHOWALD; Fiscal Year: 1992
    ..Recently, however, ovo has been shown to be active in a sex-specific manner as early as the blastoderm stage and that mutations in ovo cause a switch in differentiation into the male germ line pathway...
  29. INTERACTIONS BETWEEN F-ACTIN, MYOSIN II AND MICROTUBULES
    Garrett Odell; Fiscal Year: 2001
    ..II that occur in phase with mitotic cycles during pseudo cleavage furrow formation in the syncytial Drosophila blastoderm. Preliminary observations and drug experiments in Drosophila implicate rapidly changing arrays of microtubules ..
  30. INTERACTIONS BETWEEN F-ACTIN, MYOSIN II AND MICROTUBULES
    Garrett Odell; Fiscal Year: 2000
    ..II that occur in phase with mitotic cycles during pseudo cleavage furrow formation in the syncytial Drosophila blastoderm. Preliminary observations and drug experiments in Drosophila implicate rapidly changing arrays of microtubules ..
  31. GENETICS OF MORPHOGENESIS OF VERTEBRATE GASTRULATION
    DONALD KANE; Fiscal Year: 2000
    ..The gene half baked (hab) is essential for the process of epiboly, the vegetalwards spreading of the blastoderm to cover the large yolk cell...
  32. GENETICS OF MORPHOGENESIS OF VERTEBRATE GASTRULATION
    DONALD KANE; Fiscal Year: 2002
    ..The gene half baked (hab) is essential for the process of epiboly, the vegetalwards spreading of the blastoderm to cover the large yolk cell...
  33. GENETICS OF MORPHOGENESIS OF VERTEBRATE GASTRULATION
    DONALD KANE; Fiscal Year: 2001
    ..The gene half baked (hab) is essential for the process of epiboly, the vegetalwards spreading of the blastoderm to cover the large yolk cell...
  34. GENETICS OF MORPHOGENESIS OF VERTEBRATE GASTRULATION
    DONALD KANE; Fiscal Year: 2003
    ..The gene half baked (hab) is essential for the process of epiboly, the vegetalwards spreading of the blastoderm to cover the large yolk cell...
  35. GENETICS OF MORPHOGENESIS OF VERTEBRATE GASTRULATION
    DONALD KANE; Fiscal Year: 1999
    ..The gene half baked (hab) is essential for the process of epiboly, the vegetalwards spreading of the blastoderm to cover the large yolk cell...
  36. De novo establishment of Polycomb-group-mediated repression
    Richard S Jones; Fiscal Year: 2010
    ..In the proposed studies, genetic manipulation will be used to obtain syncytial and cellular blastoderm stage embryos in which a PcG target gene is ubiquitously repressed at the syncytial blastoderm stage by a ..
  37. REGULATION AND FUNCTION OF THE DROSOPHILA GENE RUNT
    John Gergen; Fiscal Year: 1999
    ..As is the case for the others, runt shows a pair-rule pattern of expression at the blastoderm stage, because of runt's primary role it is important to understand how this pattern of expression is generated...
  38. REGULATION OF THE DROSOPHILA SEGMENTATION GENE RUNT
    John Gergen; Fiscal Year: 1990
    ..As is the case for the others, runt shows a pair-rule pattern of expression at the blastoderm stage, because of runt's primary role it is important to understand how this pattern of expression is generated...
  39. MYOSIN VI FUNCTION IN INTRACELLULAR TRANSPORT/LOCALIZATI
    Kathryn Miller; Fiscal Year: 2002
    ..shown that it is an actin-based cytoplasmic transporter involved in membrane remodeling during the syncytial blastoderm stage of development. Subsequently, we have identified myosin VI mutants that affect spermatogenesis...
  40. MYOSIN VI FUNCTION IN INTRACELLULAR TRANSPORT/LOCALIZATI
    Kathryn Miller; Fiscal Year: 2003
    ..shown that it is an actin-based cytoplasmic transporter involved in membrane remodeling during the syncytial blastoderm stage of development. Subsequently, we have identified myosin VI mutants that affect spermatogenesis...
  41. MYOSIN VI FUNCTION IN INTRACELLULAR TRANSPORT/LOCALIZATI
    Kathryn Miller; Fiscal Year: 2001
    ..shown that it is an actin-based cytoplasmic transporter involved in membrane remodeling during the syncytial blastoderm stage of development. Subsequently, we have identified myosin VI mutants that affect spermatogenesis...
  42. MYOSIN VI FUNCTION IN INTRACELLULAR TRANSPORT/LOCALIZATI
    Kathryn Miller; Fiscal Year: 2000
    ..shown that it is an actin-based cytoplasmic transporter involved in membrane remodeling during the syncytial blastoderm stage of development. Subsequently, we have identified myosin VI mutants that affect spermatogenesis...
  43. THE ROLE OF OOCYTE PROTEINS AND RNAS IN DEVELOPMENT
    Robert Grainger; Fiscal Year: 1980
    ..of egg cytoplasmic proteins into nuclei (and chromatin), as well as nucleoli, will be followed at the cellular blastoderm stage...
  44. MOLECULAR ANALYSIS OF SEGMENTATION IN DROSOPHILA
    Eric Wieschaus; Fiscal Year: 1992
    ..During these stages, the segmental pattern established at the blastoderm stage has its first consequences on cell behavior...
  45. Gene Manipulation of Cephalopod Development
    CLIFTON RAGSDALE; Fiscal Year: 2009
    ..developed methods for ex ovo culturing and for whole mount in situ hybridization for embryonic stages from the blastoderm to hatching. The investigators have also isolated a large panel of cDNAs for key developmental control genes...
  46. TRANSCRIPTIONAL REGULATION BY EPIGENETIC FACTORS
    ALEXANDER M MAZO; Fiscal Year: 2011
    ..the chromatin composition of the trxG-activated and the PcG-silenced Hox target gene Ultrabithorax at very early blastoderm stages of embryo development. During these stages epigenetic maintenance is being established...
  47. TRANSCRIPTIONAL REGULATION BY EPIGENETIC FACTORS
    ALEXANDER M MAZO; Fiscal Year: 2010
    ..the chromatin composition of the trxG-activated and the PcG-silenced Hox target gene Ultrabithorax at very early blastoderm stages of embryo development. During these stages epigenetic maintenance is being established...
  48. CELL DETERMINATION IN DROSOPHILA EMBRYOS
    Victoria Foe; Fiscal Year: 1993
    ..25 'mitotic domains', which axe clusters of cells united by locally synchronous mitosis, subdivide the embryo blastoderm surface into a complex spatial pattern...
  49. CELL DETERMINATION IN DROSOPHILIA EMBRYOS
    Victoria Foe; Fiscal Year: 1991
    ..25 'mitotic domains', which axe clusters of cells united by locally synchronous mitosis, subdivide the embryo blastoderm surface into a complex spatial pattern...
  50. CONTROL OF GENE EXPRESSION DURING DROSOPHILA DEVELOPMENT
    Leslie Pick; Fiscal Year: 1992
    ..In the cellular blastoderm, ftz RNA is distributed in seven evenly spaced stripes that surround the embryo...
  51. CONTROLLING THE ACTIVITY OF A DROS TGF-BETA HOMOLOG
    Michael O Connor; Fiscal Year: 1992
    ..melanogaster embryo will be investigated. Mutations in tld and scw cause a dorsal shift in the blastoderm fate map resulting in a partial ventralization of the embryo...
  52. Organizer Roles in A-P Neural Patterning Development
    Eric Weinberg; Fiscal Year: 2002
    ..Mutants do not properly localize B-catenin in dorsal yolk syncytial layer (YSL) or blastoderm margin nuclei, resulting in the absence or very low levels of B-catenin-mediated signaling...
  53. Organizer Roles in A-P Neural Patterning Development
    Eric Weinberg; Fiscal Year: 2004
    ..Mutants do not properly localize B-catenin in dorsal yolk syncytial layer (YSL) or blastoderm margin nuclei, resulting in the absence or very low levels of B-catenin-mediated signaling...
  54. Organizer Roles in A-P Neural Patterning Development
    Eric Weinberg; Fiscal Year: 2003
    ..Mutants do not properly localize B-catenin in dorsal yolk syncytial layer (YSL) or blastoderm margin nuclei, resulting in the absence or very low levels of B-catenin-mediated signaling...
  55. Organizer Roles in A-P Neural Patterning Development
    Eric Weinberg; Fiscal Year: 2001
    ..Mutants do not properly localize B-catenin in dorsal yolk syncytial layer (YSL) or blastoderm margin nuclei, resulting in the absence or very low levels of B-catenin-mediated signaling...
  56. PHYSIOLOGICAL MODEL OF GENE REGULATION IN DROSOPHILA
    David Sharp; Fiscal Year: 1992
    ..actions that lead to the organization of the gap and pair-rule gene expression patterns in the Drosophila blastoderm. The expression patterns of these genes undergo a refinement in spatial resolution from about fifty cell nuclei ..
  57. MOLECULAR MECHANISMS IN DEVELOPMENT
    Thomas Kornberg; Fiscal Year: 1990
    ..that the engrailed function is essential during the precellular stages of embryogenesis for the formation of the blastoderm, during the gastrulation period for normal segmentation, and throughout subsequent development for maintenance ..
  58. MOLECULAR MECHANISMS IN DEVELOPMENT
    Thomas Kornberg; Fiscal Year: 1991
    ..that the engrailed function is essential during the precellular stages of embryogenesis for the formation of the blastoderm, during the gastrulation period for normal segmentation, and throughout subsequent development for maintenance ..
  59. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1980
    ..The goal is to determine how mesenchyme cells leave the blastoderm, invade the blastocoel, and influence the organization of spicule skeletone...