intrahepatic bile ducts

Summary

Summary: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.

Top Publications

  1. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  2. ncbi Clonorchiasis: an update
    H J Rim
    Department of Paraitology, College of Medicine, Korea University, Seoul 136 705, Korea
    J Helminthol 79:269-81. 2005
  3. doi Cholangiocarcinoma: lessons from Thailand
    Banchob Sripa
    Department of Pathology, Faculty of Medicine, Thailand
    Curr Opin Gastroenterol 24:349-56. 2008
  4. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
  5. ncbi Epidemiology of liver cancer: an overview
    Petcharin Srivatanakul
    National Cancer Institute, Rajchathewee 10400, Bangkok Thailand
    Asian Pac J Cancer Prev 5:118-25. 2004
  6. ncbi Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cancer Res 64:1369-76. 2004
  7. ncbi Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy
    Alphonse E Sirica
    Division of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Medical College of Virginia Campus, Richmond, VA 23298 0297, USA
    Hepatology 41:5-15. 2005
  8. ncbi Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
    T Patel
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Hepatology 33:1353-7. 2001
  9. ncbi The epidemiology of cholangiocarcinoma
    Yasser Shaib
    Sections of Gastroenterology and Health Services Research, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Semin Liver Dis 24:115-25. 2004
  10. ncbi Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 41:506-16. 2005

Research Grants

  1. PATHOBIOLOGY OF HEPATIC EPITHELIA
    Nicholas Larusso; Fiscal Year: 2007
  2. Pathophysiology of Biliary Cryptosporidiosis
    Nicholas Larusso; Fiscal Year: 2009
  3. Pathophysiology of Biliary Cryptosporidiosis
    Nicholas Larusso; Fiscal Year: 2007
  4. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
  5. PATHOBIOLOGY OF HEPATIC EPITHELIA
    Nicholas Larusso; Fiscal Year: 2003
  6. BILE ACID MODULATION OF BILE DUCT SECRETION AND GROWTH
    Gene Lesage; Fiscal Year: 2007
  7. ROLE OF CD40-CD40 LIGAND IN PRIMARY BILIARY CIRRHOSIS
    MARLYN MAYO; Fiscal Year: 2003
  8. BILE ACID MODULATION OF BILE DUCT SECRETION AND GROWTH
    Gene D Lesage; Fiscal Year: 2010
  9. Immunologic Mechanism/Destruction/Biliary Artesia
    Cara Mack; Fiscal Year: 2006
  10. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006

Detail Information

Publications223 found, 100 shown here

  1. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  2. ncbi Clonorchiasis: an update
    H J Rim
    Department of Paraitology, College of Medicine, Korea University, Seoul 136 705, Korea
    J Helminthol 79:269-81. 2005
    ..The most effective regimen is 25 mg kg(-1) three times daily (total dose, 75 mg kg(-1)) administered orally at 5- to 6-h intervals over a single day. Prevention and control measures are also discussed...
  3. doi Cholangiocarcinoma: lessons from Thailand
    Banchob Sripa
    Department of Pathology, Faculty of Medicine, Thailand
    Curr Opin Gastroenterol 24:349-56. 2008
    ..To present the background of liver fluke-associated cholangiocarcinoma in Thailand focusing on recent epidemiological data and pathogenesis of this bile duct cancer...
  4. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
    A number of diseases are characterized by defective formation of the intrahepatic bile ducts. In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts...
  5. ncbi Epidemiology of liver cancer: an overview
    Petcharin Srivatanakul
    National Cancer Institute, Rajchathewee 10400, Bangkok Thailand
    Asian Pac J Cancer Prev 5:118-25. 2004
    ..is derived from hepatocytes, and cholangiocarcinoma, which is derived from the epithelial lining of the intrahepatic bile ducts. Hepatocellular cancer is a frequently occurring tumor in individuals in many developing countries, where ..
  6. ncbi Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cancer Res 64:1369-76. 2004
    ....
  7. ncbi Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy
    Alphonse E Sirica
    Division of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Medical College of Virginia Campus, Richmond, VA 23298 0297, USA
    Hepatology 41:5-15. 2005
    ....
  8. ncbi Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
    T Patel
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Hepatology 33:1353-7. 2001
    ..8%, respectively. In conclusion, there has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years. This tumor continues to be associated with a poor prognosis...
  9. ncbi The epidemiology of cholangiocarcinoma
    Yasser Shaib
    Sections of Gastroenterology and Health Services Research, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Semin Liver Dis 24:115-25. 2004
    ..Some data, however, point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC...
  10. ncbi Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 41:506-16. 2005
    ....
  11. ncbi ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions
    Kanenori Endo
    Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298, USA
    Hepatology 36:439-50. 2002
    ..The results also suggest ERBB-2 and COX-2 as potentially important targets relevant to chemoprevention or adjunct therapy of ChC...
  12. ncbi Cholangiocarcinoma
    Shahid A Khan
    Liver Unit, Division of Medicine, St Mary s Hospital Campus, Faculty of Medicine, Imperial College London, London, UK
    Lancet 366:1303-14. 2005
    ..However, controversy exists over the type and positioning of biliary stents. Photodynamic treatment is a new palliative technique that might improve quality of life...
  13. ncbi Unilateral versus bilateral endoscopic hepatic duct drainage in patients with malignant hilar biliary obstruction: results of a prospective, randomized, and controlled study
    G D De Palma
    Department of Surgery and Advanced Technologies, Service of Digestive Endoscopy, University of Naples Federico II, School of Medicine, Naples, Italy
    Gastrointest Endosc 53:547-53. 2001
    ..0247). CONCLUSION: The insertion of more than one stent would not appear justified as a routine procedure in patients with biliary bifurcation tumors...
  14. ncbi Serum and bile markers for cholangiocarcinoma
    Oliver Nehls
    Department of Internal Medicine I, University Hospital Tubingen, Germany
    Semin Liver Dis 24:139-54. 2004
    ..g., pancreatic polypeptide), and (epi-)genetic lesions (e.g., K- ras and p53 mutations, p16 (INK4a) or p14 (ARF) promoter hypermethylation). In this article we discuss these new potential tumor markers for the diagnosis of CC...
  15. ncbi Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case-control study in Italy
    F Donato
    Cattedra di Igiene, Universita di Brescia, Italy
    Cancer Causes Control 12:959-64. 2001
    Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) ..
  16. pmc Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
    Erin E Sparks
    Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Hepatology 51:1391-400. 2010
    Alagille syndrome, a chronic hepatobiliary disease, is characterized by paucity of intrahepatic bile ducts (IHBDs)...
  17. doi Palliative treatment with self-expandable metallic stents in patients with advanced type III or IV hilar cholangiocarcinoma: a percutaneous versus endoscopic approach
    Woo Hyun Paik
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Gastrointest Endosc 69:55-62. 2009
    ..However, little is known about which is the better option in patients with advanced hilar cholangiocarcinoma. We compared the clinical outcomes of these 2 methods of biliary decompression in these patients...
  18. doi Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 39:710-9. 2008
    ..Underexpression of MMPs in papillary cholangiocarcinoma might be associated with a favorable prognosis...
  19. ncbi Cholangiocarcinoma: current concepts and insights
    Gregory J Gores
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, MN 55905, USA
    Hepatology 37:961-9. 2003
  20. ncbi Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis
    Kelly Burak
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 99:523-6. 2004
    ..5 yr, which is dramatically higher than the rates in the general population. Variceal bleeding is a major risk factor for the later development of CCA...
  21. ncbi Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Room 442, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 11:1488-96; discussion 1496-7. 2007
    ..We suggest that these trends are largely caused by developments in imaging technology, improvements in patient selection, and advances in surgical techniques...
  22. ncbi Cholangiocarcinoma
    Konstantinos N Lazaridis
    Division of Gastroenterology and Hepatology, Center for the Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 128:1655-67. 2005
  23. pmc Surgical anatomy of the bile ducts at the hepatic hilum as applied to living donor liver transplantation
    Masayuki Ohkubo
    Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 239:82-6. 2004
    ..To evaluate anatomic variations of the biliary tree as applied to living donor liver transplantation...
  24. ncbi Result of endoscopic biliary drainage in hilar cholangiocarcinoma
    Rungsun Rerknimitr
    Gastroenterology Unit, Department of Internal Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    J Clin Gastroenterol 38:518-23. 2004
    ..The outcome of biliary drainage in patients with advanced hilar tumors (Bismuth III or IV) was poorer than hilar tumor at earlier stages (Bismuth I or II)...
  25. pmc Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 234:507-17; discussion 517-9. 2001
    ..To analyze resectability and survival in patients with hilar cholangiocarcinoma according to a proposed preoperative staging scheme that fully integrates local, tumor-related factors...
  26. ncbi Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Gastroenterol 11:7024-7. 2005
    ....
  27. pmc Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998
    S D Taylor-Robinson
    Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Campus, South Wharf Street, London W2 1PG, UK
    Gut 48:816-20. 2001
    ..We further analysed the mortality statistics to determine which anatomical subcategories were involved...
  28. ncbi CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma
    Min Cheng Su
    Department of Pathology, Min Sheng General Hospital, 168 Ching Kuo Road, Taoyuan City, Taiwan, ROC
    Cancer Lett 235:34-9. 2006
    ..In a multivariant analysis, CD24 expression and tumor stage were independent prognostic factors. Our data suggest that CD24 expression in intrahepatic cholangiocarcinoma is a novel prognostic marker for intrahepatic cholangiocarcinoma...
  29. doi Ursodeoxycholic acid in neonatal hepatitis and infantile paucity of intrahepatic bile ducts: review of a historical cohort
    M A Kotb
    Department of Pediatrics, Cairo University, El Mokatam, 11571 Cairo, Egypt
    Dig Dis Sci 54:2231-41. 2009
    ..418 (P = 0.040) and that of deterioration was 2.64 (P = 0.028). Ursodeoxycholic acid failed in management of this cohort of infants with nonsurgical cholestasis...
  30. ncbi Impact of pretreatment cholinesterase level on survival of inoperable intrahepatic or hepatic-hilar carcinomas treated with three-dimensional conformal radiotherapy
    Yasushi Hamamoto
    Department of Radiology, Sikoku Cancer Center, 13 Horinouchi, Matsuyama City, Ehime 790 0007, Japan
    Radiat Med 22:316-23. 2004
    ....
  31. ncbi p53 Mutations in human cholangiocarcinoma: a review
    Shahid A Khan
    Liver Unit, St Mary s Campus, Hammersmith Hospital Campus, Faculty of Medicine, Imperial College, London, UK
    Liver Int 25:704-16. 2005
    ..The structure and function of p53 and its role in linking cancer to specific carcinogens by way of mutational signatures is reviewed. The findings of previous p53 studies and their relevance in human cholangiocarcinoma are summarised...
  32. doi Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts
    Andreas Weber
    Department of Gastroenterology, Technical University of Munich, Germany
    Eur J Radiol 72:412-7. 2009
    ..Major complications occurred in 17/419 patients (4%). Patients with nondilated intrahepatic bile ducts had significantly higher complication rates compared to patients with dilated intrahepatic bile ducts (14...
  33. doi Anatomic variations in intrahepatic bile ducts in a north Indian population
    Vijay Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 23:e58-62. 2008
    In the present study, we described the anatomical variations in the branching patterns of intrahepatic bile ducts (IHD) and determined the frequency of each variation in north Indian patients. There are no data from India.
  34. ncbi Pathology of cholangiocarcinoma
    J H Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, 135 710 Seoul, Kangnam Ku, Korea
    Abdom Imaging 29:540-7. 2004
  35. ncbi Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma
    Carlos U Corvera
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 201:862-9. 2005
    ..Nontraumatic inflammatory hilar strictures are uncommon, but are known to mimic malignancy. This study examines the clinical and pathologic features of benign idiopathic strictures...
  36. ncbi A review and update on cholangiocarcinoma
    Matthew J Olnes
    Department of Internal Medicine, Johns Hopkins Bayview Medical Center and Johns Hopkins School of Medicine, Baltimore, MD, USA
    Oncology 66:167-79. 2004
    ..Particular focus is on recent studies into the cellular and molecular pathogenesis of the disease, recent chemotherapy trials, and newer methods of staging and screening for this devastating malignancy...
  37. ncbi Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
    L C Pederson
    Department of Surgery, University of Alabama at Birmingham, 35294, USA
    Cancer Res 57:4325-32. 1997
    ..Radiobiological survival curve parameters confirmed an interactive cytotoxic effect when viral infection and prodrug therapy were combined with external beam radiation exposure. (ABSTRACT TRUNCATED)..
  38. ncbi Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma
    Nathalie Wong
    Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Hepatol 37:633-9. 2002
    ..Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior...
  39. ncbi The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma
    Byung Kyu Park
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Am J Clin Oncol 29:138-42. 2006
    ..Lymphatic spread is a key prognostic factor in intrahepatic cholangiocarcinoma (ICC). We studied the expression of VEGF-C in ICC tissues to clarify its clinicopathologic significance...
  40. ncbi Endoscopic management of liver abscesses and cysts that communicate with intrahepatic bile ducts
    B C Sharma
    Department of Gastroenterology, Rm No 203, 2nd Floor Academic Block, GB Pant Hospital, New Delhi 110002, India
    Endoscopy 38:249-53. 2006
    The formation of a communication between liver abscesses or cysts and intrahepatic bile ducts is an uncommon cause of significant bile leak. Surgical management of biliary fistulas is associated with high morbidity and mortality...
  41. doi Matrix proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's disease
    Mitsue Yasoshima
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Pathol 217:442-51. 2009
    ..Immunostaining showed that basement membrane expression of laminin and type IV collagen around intrahepatic bile ducts was degraded in CHF, Caroli's disease, and the PCK rats...
  42. pmc Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution
    Michelle L DeOliveira
    Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Ann Surg 245:755-62. 2007
    ..To assess long-term survival and prognostic factors in a large series of patients with bile duct cancer...
  43. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ..the presence of mitochondria in virtually all nucleated cells, the destruction in PBC is limited to small intrahepatic bile ducts. The reasons for this tissue specificity remain unknown, although biliary epithelial cells (BECs) ..
  44. doi Cholangiocarcinoma
    Stefania Mosconi
    Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy
    Crit Rev Oncol Hematol 69:259-70. 2009
    ....
  45. doi Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells
    Shinji Shimoda
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatology 47:958-65. 2008
    Primary biliary cirrhosis (PBC) is characterized by the highly selective autoimmune injury of small intrahepatic bile ducts, despite widespread distribution of mitochondrial autoantigens...
  46. ncbi Long-term results following resectional surgery for Klatskin tumors. A twenty-year personal experience
    N J Lygidakis
    Department of Surgical Oncology, Athens Medical Center, Apollonion Hospital, Athens, Greece
    Hepatogastroenterology 48:95-101. 2001
    ....
  47. ncbi Regulation of cholangiocyte bicarbonate secretion
    N Kanno
    Department of Internal Medicine, Scott and White Hospital and Texas A and M University System Health Science Center, College of Medicine, TX 76504, USA
    Am J Physiol Gastrointest Liver Physiol 281:G612-25. 2001
    ..by which secretin stimulates ductal secretion, we discuss the heterogeneous responses of different-sized intrahepatic bile ducts to gastrointestinal hormones. Furthermore, we outline the role of a number of cooperative factors (e.g...
  48. ncbi Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University School of Medicine, Seiryo, Aobaku, Sendai, Japan
    Liver Int 23:449-59. 2003
    We have shown that large and small cholangiocytes, which reside primarily in large and small intrahepatic bile ducts, respectively, have different functions and responses to injuries...
  49. ncbi Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines
    Gao song Wu
    Department of General Surgery, Tongji Hospital, 1095 Jiefang Road, Wuhan, 430030, Hubei Province, China
    World J Gastroenterol 9:1302-6. 2003
    ..To evaluate the roles and mechanisms of celecoxib in inducing proliferation inhibition and apoptosis of human cholangiocarcinoma cell lines...
  50. ncbi Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma--a study of 51 cases from a low-endemicity area
    J Kaczynski
    Department of Medicine, , Sahlgren's University Hospital, Ostra, Sweden
    Acta Oncol 37:77-83. 1998
    ..The most common histological features were tubular pattern of growth (82%) and abundant fibrous stroma. Metastases were particularly associated with the lymph nodes (41%), skeleton (26%) and lungs (16%)...
  51. ncbi Is a raised CA 19-9 level diagnostic for a cholangiocarcinoma in patients with no history of sclerosing cholangitis ?
    Abraham R John
    Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Dig Surg 23:319-24. 2006
    ..The aim of this study is to assess the role of CA 19-9 in patients with a cholangiocarcinoma without primary sclerosing cholangitis...
  52. ncbi iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Cancer 119:1067-72. 2006
    ..It is concluded that praziquantel can exhibit a preventive effect against OV-induced cholangiocarcinoma by inhibiting iNOS-dependent DNA damage through not only elimination of parasites but also a potential antiinflammatory effect...
  53. ncbi Knockout of alpha-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice
    Shannon S Glaser
    Department of Medicine, Scott and White Hospital, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    Lab Invest 87:914-26. 2007
    ..In conclusion, sensory innervation of the liver and biliary expression of alpha-CGRP play an important role in the regulation of cholangiocyte proliferation during cholestasis...
  54. ncbi Scavenger cells with gram-positive bacterial lipoteichoic acid infiltrate around the damaged interlobular bile ducts of primary biliary cirrhosis
    K Tsuneyama
    Department of Pathology (II, School of Medicine, Kanazawa University, Japan
    J Hepatol 35:156-63. 2001
    ..Such LTA may be involved in the development and progression of portal tract lesions, particularly bile duct lesions, in PBC...
  55. pmc Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Gut 47:721-7. 2000
    ..Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and K-ras mutations are among the most frequent genetic alterations in human malignancies...
  56. ncbi Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Dig Dis Sci 46:2166-72. 2001
    ..aims of this study were to determine the possible alteration of mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas and to try to predict whether or not hepatolithiasis has a predisposition to ..
  57. ncbi Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
    G Y Gwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, South Korea
    J Cancer Res Clin Oncol 131:649-52. 2005
    ..The response-predicting mutations in the tyrosine kinase domain of EGFR gene have recently been detected in non-small cell lung cancers. This study was, therefore, to investigate if these mutations are also found in cholangiocarcinomas...
  58. ncbi Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    Kumiko Nakazawa
    Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
    J Pathol 206:356-65. 2005
    ..4%), was not associated with gene amplification. It is proposed that the new adjuvant chemotherapies could be directed to carcinomas of the biliary tract in which ErbB-2 and EGFR are overexpressed...
  59. ncbi Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study
    Yasser H Shaib
    The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
    Am J Gastroenterol 102:1016-21. 2007
    ..We evaluated hepatitis C virus (HCV), hepatitis B virus (HBV), and liver cirrhosis as risk factors for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC)...
  60. ncbi Aberrant expression of laminin gamma 2 chain and its prognostic significance in intrahepatic cholangiocarcinoma according to growth morphology
    Shinichi Aishima
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka Japan
    Mod Pathol 17:938-45. 2004
    ..We conclude that laminin gamma 2 chain exhibits aberrant expression in a stepwise manner through different aggressive stages of tumor progression...
  61. ncbi Current approaches to the diagnosis and treatment of cholangiocarcinoma
    Santosh B Reddy
    Department of Internal Medicine, Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center, 2401 South 31st Street, Temple, TX 76508, USA
    Curr Gastroenterol Rep 8:30-7. 2006
    ..Although surgical resection can be curative, many patients with cholangiocarcinoma are diagnosed at an advanced stage when only palliative approaches can be used. Photodynamic therapy is emerging as a useful modality...
  62. ncbi Gemcitabine concurrent with continuous infusional 5-fluorouracil in advanced biliary cancers: a review of the Princess Margaret Hospital experience
    J J Knox
    Departments of Hematology and Medical Oncology, Princess Margaret Hospital University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Ann Oncol 15:770-4. 2004
    ..Unresectable biliary tract cancer has a very poor prognosis. A combination of weekly gemcitabine plus continuous infusional 5-fluorouracil (5-FU) (GEM/CVI 5-FU) was evaluated as therapy for this cancer...
  63. pmc Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis
    Motoko Sasaki
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Clin Pathol 60:1102-7. 2007
    ..Recent studies suggest that naturally-occurring CD4+CD25high regulatory T cells (Tregs) expressing Forkhead box P3 (Foxp3) play an active role in immunological self-tolerance...
  64. ncbi Clinicopathologic features, diagnosis and surgical treatment of intrahepatic cholangiocarcinoma in 104 patients
    Xiao Hui Fu
    Department of Comprehensive Therapy of Hepatobiliary Tumors, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
    Hepatobiliary Pancreat Dis Int 3:279-83. 2004
    ..The outcome of surgical treatment of patients with intrahepatic cholangiocarcinoma (ICC) is poor. This study was designed to analyze the relationship between clinicopathologic features and the survival time after operation...
  65. ncbi Resectability and prognostic factors after resection of hilar cholangiocarcinoma
    M Abdel Wahab
    Gastroenterology Center, Mansoura University, Egypt
    Hepatogastroenterology 53:5-10. 2006
    ..Hilar cholangiocarcinoma, still a challenging problem for surgeons and resectional surgery, is the treatment of choice for long-term survival. In this study we tried to evaluate different prognostic factors after resection...
  66. ncbi Long isoform of prolactin receptor predominates in rat intrahepatic bile ducts and further increases under obstructive cholestasis
    R L Bogorad
    Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob ev Hills, 119992, Moscow, Russian Federation
    J Endocrinol 188:345-54. 2006
    ..From these data, the actions of prolactin on liver are anticipated to exhibit strong cell-type specificity in both normal and pathological conditions...
  67. pmc Cholangiocarcinoma: modern advances in understanding a deadly old disease
    Harmeet Malhi
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Hepatol 45:856-67. 2006
    ..Future targeted therapies will depend on a better understanding of the cellular and molecular biology of cholangiocarcinomas...
  68. ncbi Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:873-5. 2006
    ..001)...
  69. ncbi Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study
    Yasser H Shaib
    Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 128:620-6. 2005
    ..In this case-control study, we used the Surveillance, Epidemiology, and End Results-Medicare database to evaluate the prevalence of known risk factors for intrahepatic cholangiocarcinoma and explore other potential risk factors...
  70. ncbi Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)
    Banchob Sripa
    Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    World J Gastroenterol 11:3392-7. 2005
    ..To establish and characterize a new cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand...
  71. ncbi A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:1198-203. 2006
    ..In conclusion, the rates of HCC and ICC approximately doubled between 1976 and 2000. Trends by age, gender, ethnicity, and birth cohort suggest that heterogeneity exists in the factors influencing these rates...
  72. ncbi [Expression of epidermal growth factor receptor, ErbB2 and matrix metalloproteinase-9 in hepatolithiasis and cholangiocarcinoma]
    Hyo Jung Kim
    Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Korea
    Korean J Gastroenterol 45:52-9. 2005
    ..However, there has been few studies on the expressions and roles of EGFR and MMP in hepatolithiasis. This study was performed to clarify and compare the expressions of EGFR, erbB2 and MMP-9 in hepatolithiasis and cholangiocarcinoma...
  73. ncbi The ratio of MMP-2 to TIMP-2 in hilar cholangiocarcinoma: a semi-quantitative study
    Mei Xiao
    Department of Hepatobiliary Surgery of General Airforce of Hospital, Beijing 100036, China
    Hepatobiliary Pancreat Dis Int 3:599-602. 2004
    ..The aim of this study was to evaluate the roles of matrix metalloproteinases-2 (MMP-2) and its tissue inhibitor of metalloproteinase-2(TIMP-2) in tumor invasion or as a prognostic factor in patients with human hilar cholangiocarcinoma...
  74. ncbi Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells
    Jung Hwan Yoon
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, South Korea
    J Hepatol 41:808-14. 2004
    ..However, the characteristics of EGFR signaling in cholangiocarcinoma cells have not been characterized. Thus, we attempted to more fully characterize EGF/EGFR signaling in human cholangiocarcinoma cells...
  75. ncbi The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ..Furthermore, embryonic Foxm1b -/- livers did not develop intrahepatic bile ducts, and these presumptive biliary hepatoblasts failed to express either biliary cytokeratins or nuclear ..
  76. ncbi Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma
    Shusaku Ohira
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 56:381-9. 2006
    ..In conclusion, local mutual influence of TGF-beta1 secreted from carcinoma cells and SDF-1 expressed by stromal fibroblasts may be involved in invasion of CC cells...
  77. ncbi Akt expression may predict favorable prognosis in cholangiocarcinoma
    Milind M Javle
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Gastroenterol Hepatol 21:1744-51. 2006
    ..The aim of this clinicopathological study was to investigate the overexpression and co-expression of EGFR and related signaling proteins in cholangiocarcinoma and explore their relationship to clinical outcome...
  78. pmc Anatomic variation in intrahepatic bile ducts: an analysis of intraoperative cholangiograms in 300 consecutive donors for living donor liver transplantation
    Jin Woo Choi
    Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
    Korean J Radiol 4:85-90. 2003
    To describe the anatomical variation occurring in intrahepatic bile ducts (IHDs) in terms of their branching patterns, and to determine the frequency of each variation.
  79. pmc Etiopathogenesis of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis, CA 95616, USA
    World J Gastroenterol 14:3328-37. 2008
    ..In this article, we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data, new developments and theories, and nominate directions for future research...
  80. ncbi Cholangiocarcinoma: morphologic classification according to growth pattern and imaging findings
    Jae Hoon Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, South Korea
    AJR Am J Roentgenol 181:819-27. 2003
  81. ncbi DNA analysis of cholangiocarcinoma cells: prognostic and clinical importance
    Hassan Abou-Rebyeh
    Department of Internal Medicine, Hepatology and Gastroenterology, Humboldt University, Charite, Berlin, Germany
    Cancer Detect Prev 26:313-9. 2002
    ..DNA ploidy reflecting irregularities of chromosome number and content might be an alternative predictor. In this study, we evaluated the DNA ploidy as a prognostic factor for survival of patients after resection of cholangiocarcinoma...
  82. ncbi The value of biliary fibronectin for diagnosis of cholangiocarcinoma
    Chiung Yu Chen
    Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Hepatogastroenterology 50:924-7. 2003
    ..The fibronectin in various body fluids was reported to be useful in the differential diagnosis of benign and malignant diseases. We conducted this study to assess the diagnostic value of biliary fibronectin...
  83. pmc Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
    D Yoshikawa
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 98:418-25. 2008
    ..89; 95% CI, 1.05-3.39, P=0.0335) in IHCC. These results suggest that EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma...
  84. pmc Results of surgical resection for patients with hilar bile duct cancer: application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization
    Seiji Kawasaki
    First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Ann Surg 238:84-92. 2003
    ..To evaluate the feasibility of an aggressive surgical approach incorporating major hepatic resection after biliary drainage and preoperative portal vein embolization for patients with hilar bile duct cancer...
  85. doi Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study
    Tae Y Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Am J Gastroenterol 103:1716-20. 2008
    ..Several studies have suggested that hepatitis C virus (HCV) infection may play a role in the development of ICC, whereas the role of hepatitis B virus (HBV) infection is less clear...
  86. ncbi Immunohistochemical evidence for hepatic progenitor cells in liver diseases
    Jianyou Tan
    Department of Pathology, New York University Medical Center, New York, NY 10016, USA
    Liver 22:365-73. 2002
    ..We investigated bile ductular reactions in liver diseases, paying particular attention to the presence of cells with intermediate (hepatocytic/biliary) features (oval-like cells)...
  87. ncbi Preoperative biliary drainage for hilar cholangiocarcinoma
    Hiroyuki Maguchi
    Center for Gastroenterology, Teine Keijinkai Hospital, 1 jo 12 chome, Maeda, Sapporo, 006 8555, Japan
    J Hepatobiliary Pancreat Surg 14:441-6. 2007
    ..ENBD needs to be converted to PTBD in patients with segmental cholangitis, those with a prolonged need for drainage, or when the extent of longitudinal tumor extension is not sufficiently well characterized...
  88. ncbi Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis
    Hong Joo Kim
    Division of Gastroenterology and Gastrointestinal Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 19:582-8. 2004
    ..The goal of the present study was to determine the possible roles and clinical significance of COX-2 expression in CC...
  89. pmc Primary sclerosing cholangitis
    Marina G Silveira
    Miles and Shirley Center for Digestive Dieseases, Mayo Clinic and Foundation for Medical Education and Research, Rochester, MN 55905, USA
    Can J Gastroenterol 22:689-98. 2008
    ....
  90. ncbi Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma
    Chanisa Chuaysri
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Oncol Rep 21:957-69. 2009
    ..CCA fibroblasts have proliferative effects which may directly effect tumor promotion and progression of biliary epithelial cells. This warrants further investigation of fibroblasts as alternative therapeutic targets in CCA patients...
  91. ncbi Simultaneous detection of epidermal growth factor receptor (EGF-R), epidermal growth factor (EGF) and ras p21 in cholangiocarcinoma by an immunocytochemical method
    A Nonomura
    Department of Pathology, School of Medicine, Kanazawa University, Japan
    Liver 8:157-66. 1988
    ..Furthermore, the data also indicate that an autocrine model for tumor growth, as suggested by a combination of EGF and EGF-R, may be applicable only to very limited cases of CCs...
  92. ncbi Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation
    Zichen Zhang
    Division of Cellular and Molecular Pathogenesis, Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 39:1028-37. 2004
    ..Our in vivo results further suggest celecoxib might have potential therapeutic or chemopreventive value against ChC...
  93. ncbi Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis
    Ken Shirabe
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Surg 187:538-42. 2004
    ..The aim of this study was to clarify prognostic factors and recurrence patterns in patients with node-negative intrahepatic cholangiocarcinoma (IHCC)...
  94. doi High lifetime risk of cancer in primary sclerosing cholangitis
    Marian M H Claessen
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Hepatol 50:158-64. 2009
    ..Primary sclerosing cholangitis (PSC) patients are at risk for developing cholangiocarcinoma (CCA) and colorectal carcinoma (CRC). Our aim was to assess the risk of malignancies and their influence on survival...
  95. ncbi Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinoma
    George Pan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Oncol 31:843-50. 2007
    ..These findings provide a potential unifying molecular mechanism for modulating tumorigenesis via Fas/FasL expression...
  96. doi Surgical outcome and prognostic factors in intrahepatic cholangiocarcinoma
    Toshio Nakagohri
    Department of Surgery, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, 277 8577, Japan
    World J Surg 32:2675-80. 2008
    ..The clinicopathologic features and surgical outcome of intrahepatic cholangiocarcinoma are not fully understood...
  97. ncbi MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type
    Hiroaki Shibahara
    Division of Human Pathology, Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Hepatology 39:220-9. 2004
    ..In conclusion, the results suggest that expression of MUC4 in ICC-MF is a new independent factor for poor prognosis and is a useful marker to predict the outcome of the patients with ICC-MF...
  98. ncbi [Analysis of prognostic factors after curative resection for combined hepatocellular and cholangiocarcinoma]
    Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, National University Hospital, 29 Yeongeon dong, Jong no gu, Seoul, Korea
    Korean J Gastroenterol 49:158-65. 2007
    ..The aim of this study was to evaluate the prognostic factors of combined HCC-CC after curative resection...
  99. ncbi [Iatrogenic functional hemihepatectomy using radiofrequency ablation in cholangiocellular carcinoma]
    S Ernst
    Landshut
    Rofo 180:259-61. 2008
  100. ncbi [Liver resection (part I) -- anatomical basis, indication, and preoperative planning]
    K J Oldhafer
    Klinik für Allgemein und Viszeralchirurgie, AKH Celle
    Zentralbl Chir 131:W22-33; W34-5. 2006
  101. doi Radiofrequency ablation prior to liver transplantation: focus on complications and on a rare but severe case
    Robert M Eisele
    Department of General, Visceral and Transplantation Surgery, Charite Virchow Clinic, Berlin, Germany
    Clin Transplant 22:20-8. 2008
    ..Complications are thought to be rare and mostly self-limiting. By contrast, we report on a life-threatening complication and discuss it in the context of other complications...

Research Grants105 found, 100 shown here

  1. PATHOBIOLOGY OF HEPATIC EPITHELIA
    Nicholas Larusso; Fiscal Year: 2007
    ..We continue to focus on cholangiocytes, the epithelial cells lining intrahepatic bile ducts, because of their biologic and clinical importance, and because of the new concepts, hypotheses, and ..
  2. Pathophysiology of Biliary Cryptosporidiosis
    Nicholas Larusso; Fiscal Year: 2009
    ..of cell and molecular biology to understand the role of cholangiocytes, the epithelial cells lining intrahepatic bile ducts, in health and disease...
  3. Pathophysiology of Biliary Cryptosporidiosis
    Nicholas Larusso; Fiscal Year: 2007
    ..of cell and molecular biology to understand the role of cholangiocytes, the epithelial cells lining intrahepatic bile ducts, in health and disease...
  4. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..BA) appears to result from a chronic, progressive inflammatory mediated destruction of extrahepatic and intrahepatic bile ducts, leading some to call it "infantile obliterative cholangiopathy"...
  5. PATHOBIOLOGY OF HEPATIC EPITHELIA
    Nicholas Larusso; Fiscal Year: 2003
    ..We now focus principally on cholangiocytes, epithelial cells that line intrahepatic bile ducts, because of their biologic and clinical importance, the new hypotheses and techniques we have developed ..
  6. BILE ACID MODULATION OF BILE DUCT SECRETION AND GROWTH
    Gene Lesage; Fiscal Year: 2007
    ..We continue to focus on bile acid interactions with cholangiocytes, the epithelial cells lining intrahepatic bile ducts, because of the development of new hypotheses and techniques regarding the regulation of bile acid ..
  7. ROLE OF CD40-CD40 LIGAND IN PRIMARY BILIARY CIRRHOSIS
    MARLYN MAYO; Fiscal Year: 2003
    ..is a chronic autoimmune liver disease characterized by inflammatory destruction of small and medium sized intrahepatic bile ducts, leading to cholestasis, then fibrosis, cirrhosis, and its complications...
  8. BILE ACID MODULATION OF BILE DUCT SECRETION AND GROWTH
    Gene D Lesage; Fiscal Year: 2010
    ..We continue to focus on bile acid interactions with cholangiocytes, the epithelial cells lining intrahepatic bile ducts, because of the development of new hypotheses and techniques regarding the regulation of bile acid ..
  9. Immunologic Mechanism/Destruction/Biliary Artesia
    Cara Mack; Fiscal Year: 2006
    ..cholangiopathy of infancy that leads to fibrosis and obliteration of both the extrahepatic and intrahepatic bile ducts. The immune response appears to be the key player in the ongoing destruction of the bile ducts...
  10. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006
    PBC is an autoimmune liver disease characterized by obstruction of intrahepatic bile ducts and high titer antimitochondrial autoantibodies (AMA). The predominant autoantigen is PDC-E2...
  11. Formation of bile ducts in three dimensional culture
    Keith E Mostov; Fiscal Year: 2010
    The branching tree of intrahepatic bile ducts is lined by a monolayer of epithelial cells, known as cholangiocytes. During development hepatocytes and cholangiocytes arise from bipotential hepatoblast precursors...
  12. NTPDase2 expression and function in the liver
    JONATHAN DRANOFF; Fiscal Year: 2005
    ..The ectonucleotidase NTPDase2 was found to be expressed in portal fibroblasts (PF) surrounding intrahepatic bile ducts, which provides a likely explanation for the selective hydrolysis of nucleotides at the basolateral ..
  13. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2007
    ..specific, autoimmune disease characterized by antimitochondrial antibodies and progressive destruction of intrahepatic bile ducts. There has not been an animal model of PBC and studies are dependent on human clinical specimens, a ..
  14. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..autoimmune disease characterized by antimito- chondrial antibodies and progressive destruction of intrahepatic bile ducts. There has not been an animal model of PBC and studies are dependent on human clinical specimens, a ..
  15. REGULATION OF SECRETION BY BILE DUCT EPITHELIAL CELLS
    JOHN FITZ; Fiscal Year: 2006
    ..mechanisms responsible for secretion by cholangiocytes, the epithelial cells that line the lumen of intrahepatic bile ducts and account for approximately 40 percent) of bile volume in man...
  16. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2007
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. ..
  17. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2010
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  18. Organelle Dysfunction and Apoptosis in Liver Epithelia
    Gregory Gores; Fiscal Year: 2007
    ..The significance of the information generated is that it will provide a framework for the potential development of novel therapeutic strategies effective in attenuating human liver injury. ..
  19. MECHANISMS OF LIVER CELL INJURY
    Gregory Gores; Fiscal Year: 2007
    ..The significance of the information generated is that it will help provide a framework for the potential development of novel therapeutic strategies effective in attenuating cholestatic liver injury. ..
  20. Organelle Dysfunction and Apoptosis in Liver Epithelia
    Gregory Gores; Fiscal Year: 2009
    ..Lysosome disruption results in the release of toxic compounds into the cell culminating in cell demise. The results of these studies are germane both to mechanisms of liver injury and the use of TRAIL as a chemotherapeutic agent. ..
  21. Organelle Dysfunction and Apoptosis in Liver Epithelia
    Gregory J Gores; Fiscal Year: 2010
    ..Lysosome disruption results in the release of toxic compounds into the cell culminating in cell demise. The results of these studies are germane both to mechanisms of liver injury and the use of TRAIL as a chemotherapeutic agent. ..
  22. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2010
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  23. Mechanisms of Carcinogenesis in Biliary Epithelia
    Gregory Gores; Fiscal Year: 2005
    ..Successful completion of these proposed studies has the potential for development of new strategies to prevent and treat malignant human liver diseases. ..
  24. Mechanisms of Carcinogenesis in Biliary Epithelia
    Gregory J Gores; Fiscal Year: 2010
    ..The information emanating from these studies may potentially help identify therapeutic strategies for the treatment and/or chemoprevention of cholangiocarcinoma. ..
  25. Mechanisms of Carcinogenesis in Biliary Epithelia
    Gregory Gores; Fiscal Year: 2007
    ..The information emanating from these studies may potentially help identify therapeutic strategies for the treatment and/or chemoprevention of cholangiocarcinoma. ..
  26. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL GERSHWIN; Fiscal Year: 2007
    ..Lay Summary: In this application we hope to determine the genetic basis that leads to a prototypic autoimmune disease, called primary biliary cirrhosis. ..
  27. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2006
    ..These studies are also critical for determining whether the immune response alone is essential for disease induction, or whether the unique milieu of human liver is required. ..
  28. Molecular and Functional Analysis of CASK in Epithelia
    Zenta Walther; Fiscal Year: 2005
    ..We anticipate these studies will shed considerable light on the molecular interactions of CASK, its role in growth factor complex assembly and/or signal transduction, and its potential involvement in tumorigenesis. ..
  29. Genetic and epigenetic regulation of Hepatitis B contributes to liver cancer
    Michael S Torbenson; Fiscal Year: 2010
    ..abstract_text> ..
  30. Occult Hepatitis B
    Michael Torbenson; Fiscal Year: 2007
    ..abstract_text> ..
  31. Genetic and epigenetic regulation of Hepatitis B contributes to liver cancer
    Michael Torbenson; Fiscal Year: 2009
    ....
  32. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
    ..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
  33. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
    ..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
  34. TGF-B Mediated Fibrosis in a Hepatic Stellate Cell Model
    Rebecca Wells; Fiscal Year: 2005
    ..This study will increase our understanding of TGF-beta mediated fibrosis in HSC and will enable the design of rational anti-fibrotic therapies. ..
  35. Mouse Models for Celiac Disease
    Detlef Schuppan; Fiscal Year: 2007
    ..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..