intrahepatic bile ducts

Summary

Summary: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.

Top Publications

  1. ncbi Cholangiocarcinoma
    Shahid A Khan
    Liver Unit, Division of Medicine, St Mary s Hospital Campus, Faculty of Medicine, Imperial College London, London, UK
    Lancet 366:1303-14. 2005
  2. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  3. ncbi Clonorchiasis: an update
    H J Rim
    Department of Paraitology, College of Medicine, Korea University, Seoul 136 705, Korea
    J Helminthol 79:269-81. 2005
  4. ncbi Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
    T Patel
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Hepatology 33:1353-7. 2001
  5. ncbi Cholangiocarcinoma and Clonorchis sinensis infection: a case-control study in Korea
    Dongil Choi
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, IlWon Dong, Kangnam Ku, Seoul 135 710, South Korea
    J Hepatol 44:1066-73. 2006
  6. pmc Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Gut 47:721-7. 2000
  7. pmc Cholangiocarcinoma: lessons from Thailand
    Banchob Sripa
    Department of Pathology, Faculty of Medicine, Thailand
    Curr Opin Gastroenterol 24:349-56. 2008
  8. ncbi High lifetime risk of cancer in primary sclerosing cholangitis
    Marian M H Claessen
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Hepatol 50:158-64. 2009
  9. ncbi Cholangiocarcinoma
    Tushar Patel
    Texas A and M Health Science Center College of Medicine, Scott and White Clinic, Temple, TX 76508, USA
    Nat Clin Pract Gastroenterol Hepatol 3:33-42. 2006
  10. ncbi Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study
    Yasser H Shaib
    Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 128:620-6. 2005

Detail Information

Publications244 found, 100 shown here

  1. ncbi Cholangiocarcinoma
    Shahid A Khan
    Liver Unit, Division of Medicine, St Mary s Hospital Campus, Faculty of Medicine, Imperial College London, London, UK
    Lancet 366:1303-14. 2005
    ..However, controversy exists over the type and positioning of biliary stents. Photodynamic treatment is a new palliative technique that might improve quality of life...
  2. pmc Liver fluke induces cholangiocarcinoma
    Banchob Sripa
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Med 4:e201. 2007
  3. ncbi Clonorchiasis: an update
    H J Rim
    Department of Paraitology, College of Medicine, Korea University, Seoul 136 705, Korea
    J Helminthol 79:269-81. 2005
    ..The most effective regimen is 25 mg kg(-1) three times daily (total dose, 75 mg kg(-1)) administered orally at 5- to 6-h intervals over a single day. Prevention and control measures are also discussed...
  4. ncbi Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
    T Patel
    Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
    Hepatology 33:1353-7. 2001
    ..8%, respectively. In conclusion, there has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years. This tumor continues to be associated with a poor prognosis...
  5. ncbi Cholangiocarcinoma and Clonorchis sinensis infection: a case-control study in Korea
    Dongil Choi
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, IlWon Dong, Kangnam Ku, Seoul 135 710, South Korea
    J Hepatol 44:1066-73. 2006
    ..The authors conducted a hospital-based case-control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of cholangiocarcinoma (CC), including extrahepatic CC, in Korea...
  6. pmc Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver
    A Tannapfel
    Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
    Gut 47:721-7. 2000
    ..Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and K-ras mutations are among the most frequent genetic alterations in human malignancies...
  7. pmc Cholangiocarcinoma: lessons from Thailand
    Banchob Sripa
    Department of Pathology, Faculty of Medicine, Thailand
    Curr Opin Gastroenterol 24:349-56. 2008
    ..To present the background of liver fluke-associated cholangiocarcinoma in Thailand focusing on recent epidemiological data and pathogenesis of this bile duct cancer...
  8. ncbi High lifetime risk of cancer in primary sclerosing cholangitis
    Marian M H Claessen
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Hepatol 50:158-64. 2009
    ..Primary sclerosing cholangitis (PSC) patients are at risk for developing cholangiocarcinoma (CCA) and colorectal carcinoma (CRC). Our aim was to assess the risk of malignancies and their influence on survival...
  9. ncbi Cholangiocarcinoma
    Tushar Patel
    Texas A and M Health Science Center College of Medicine, Scott and White Clinic, Temple, TX 76508, USA
    Nat Clin Pract Gastroenterol Hepatol 3:33-42. 2006
    ....
  10. ncbi Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study
    Yasser H Shaib
    Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 128:620-6. 2005
    ..In this case-control study, we used the Surveillance, Epidemiology, and End Results-Medicare database to evaluate the prevalence of known risk factors for intrahepatic cholangiocarcinoma and explore other potential risk factors...
  11. ncbi Immunohistochemical evidence for hepatic progenitor cells in liver diseases
    Jianyou Tan
    Department of Pathology, New York University Medical Center, New York, NY 10016, USA
    Liver 22:365-73. 2002
    ..We investigated bile ductular reactions in liver diseases, paying particular attention to the presence of cells with intermediate (hepatocytic/biliary) features (oval-like cells)...
  12. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
    A number of diseases are characterized by defective formation of the intrahepatic bile ducts. In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts...
  13. ncbi The epidemiology of cholangiocarcinoma
    Yasser Shaib
    Sections of Gastroenterology and Health Services Research, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Semin Liver Dis 24:115-25. 2004
    ..Some data, however, point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC...
  14. ncbi Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case-control study in Italy
    F Donato
    Cattedra di Igiene, Universita di Brescia, Italy
    Cancer Causes Control 12:959-64. 2001
    Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) ..
  15. ncbi Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 41:506-16. 2005
    ....
  16. ncbi Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cancer Res 64:1369-76. 2004
    ....
  17. ncbi Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma
    Nathalie Wong
    Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Hepatol 37:633-9. 2002
    ..Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior...
  18. pmc Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution
    Michelle L DeOliveira
    Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Ann Surg 245:755-62. 2007
    ..To assess long-term survival and prognostic factors in a large series of patients with bile duct cancer...
  19. ncbi Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis
    Kelly Burak
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 99:523-6. 2004
    ..5 yr, which is dramatically higher than the rates in the general population. Variceal bleeding is a major risk factor for the later development of CCA...
  20. ncbi Hepatic segmentectomy with caudate lobe resection for bile duct carcinoma of the hepatic hilus
    Y Nimura
    First Department of Surgery, Nagoya University School of Medicine, Japan
    World J Surg 14:535-43; discussion 544. 1990
    ....
  21. ncbi Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:873-5. 2006
    ..001)...
  22. ncbi Mucin-hypersecreting bile duct tumor characterized by a striking homology with an intraductal papillary mucinous tumor (IPMT) of the pancreas
    H J Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Endoscopy 32:389-93. 2000
    ..CONCLUSION: The mucin-hypersecreting bile duct tumor can be characterized by a striking homology with IPMT of the pancreas in clinical, radiologic, and pathologic features...
  23. ncbi Serum and bile markers for cholangiocarcinoma
    Oliver Nehls
    Department of Internal Medicine I, University Hospital Tubingen, Germany
    Semin Liver Dis 24:139-54. 2004
    ..g., pancreatic polypeptide), and (epi-)genetic lesions (e.g., K- ras and p53 mutations, p16 (INK4a) or p14 (ARF) promoter hypermethylation). In this article we discuss these new potential tumor markers for the diagnosis of CC...
  24. ncbi ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions
    Kanenori Endo
    Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298, USA
    Hepatology 36:439-50. 2002
    ..The results also suggest ERBB-2 and COX-2 as potentially important targets relevant to chemoprevention or adjunct therapy of ChC...
  25. pmc Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
    Erin E Sparks
    Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Hepatology 51:1391-400. 2010
    Alagille syndrome, a chronic hepatobiliary disease, is characterized by paucity of intrahepatic bile ducts (IHBDs)...
  26. ncbi Results of surgical treatment for intrahepatic cholangiocarcinoma and clinicopathological factors influencing survival
    M Ohtsuka
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8670, Japan
    Br J Surg 89:1525-31. 2002
    ..The results of surgical treatment for intrahepatic cholangiocarcinoma (ICC) and specific factors influencing survival are still unclear...
  27. ncbi Palliative treatment with self-expandable metallic stents in patients with advanced type III or IV hilar cholangiocarcinoma: a percutaneous versus endoscopic approach
    Woo Hyun Paik
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Gastrointest Endosc 69:55-62. 2009
    ..However, little is known about which is the better option in patients with advanced hilar cholangiocarcinoma. We compared the clinical outcomes of these 2 methods of biliary decompression in these patients...
  28. ncbi Cholangiocarcinoma: current concepts and insights
    Gregory J Gores
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, MN 55905, USA
    Hepatology 37:961-9. 2003
  29. ncbi Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 39:710-9. 2008
    ..Underexpression of MMPs in papillary cholangiocarcinoma might be associated with a favorable prognosis...
  30. ncbi Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Room 442, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 11:1488-96; discussion 1496-7. 2007
    ..We suggest that these trends are largely caused by developments in imaging technology, improvements in patient selection, and advances in surgical techniques...
  31. ncbi Unilateral versus bilateral endoscopic hepatic duct drainage in patients with malignant hilar biliary obstruction: results of a prospective, randomized, and controlled study
    G D De Palma
    Department of Surgery and Advanced Technologies, Service of Digestive Endoscopy, University of Naples Federico II, School of Medicine, Naples, Italy
    Gastrointest Endosc 53:547-53. 2001
    ..0247). CONCLUSION: The insertion of more than one stent would not appear justified as a routine procedure in patients with biliary bifurcation tumors...
  32. ncbi The role of notch signaling in the development of intrahepatic bile ducts
    Yuzo Kodama
    Department of Gastroenterology and Hepatology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Gastroenterology 127:1775-86. 2004
    ..in Jagged1 , a Notch ligand, cause Alagille syndrome (AGS), a disorder characterized by a paucity of intrahepatic bile ducts (IHBD)...
  33. ncbi Epidemiology of liver cancer: an overview
    Petcharin Srivatanakul
    National Cancer Institute, Rajchathewee 10400, Bangkok Thailand
    Asian Pac J Cancer Prev 5:118-25. 2004
    ..is derived from hepatocytes, and cholangiocarcinoma, which is derived from the epithelial lining of the intrahepatic bile ducts. Hepatocellular cancer is a frequently occurring tumor in individuals in many developing countries, where ..
  34. ncbi Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours
    A Altimari
    Pathology Unit of the F Addarii Institute of Oncology, Department of Oncology and Hematology, University of Bologna, Viale Ercolani 412, 40138 Bologna, Italy
    Dig Liver Dis 35:332-8. 2003
    ..Molecular targets are needed for primary liver tumours...
  35. ncbi iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel
    Somchai Pinlaor
    Department of Parasitology, Khon Kaen University, Thailand
    Int J Cancer 119:1067-72. 2006
    ..It is concluded that praziquantel can exhibit a preventive effect against OV-induced cholangiocarcinoma by inhibiting iNOS-dependent DNA damage through not only elimination of parasites but also a potential antiinflammatory effect...
  36. ncbi Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation
    Zichen Zhang
    Division of Cellular and Molecular Pathogenesis, Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Hepatology 39:1028-37. 2004
    ..Our in vivo results further suggest celecoxib might have potential therapeutic or chemopreventive value against ChC...
  37. ncbi Result of endoscopic biliary drainage in hilar cholangiocarcinoma
    Rungsun Rerknimitr
    Gastroenterology Unit, Department of Internal Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    J Clin Gastroenterol 38:518-23. 2004
    ..The outcome of biliary drainage in patients with advanced hilar tumors (Bismuth III or IV) was poorer than hilar tumor at earlier stages (Bismuth I or II)...
  38. ncbi Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Gastroenterol 11:7024-7. 2005
    ....
  39. pmc Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 234:507-17; discussion 517-9. 2001
    ..To analyze resectability and survival in patients with hilar cholangiocarcinoma according to a proposed preoperative staging scheme that fully integrates local, tumor-related factors...
  40. pmc Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998
    S D Taylor-Robinson
    Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Campus, South Wharf Street, London W2 1PG, UK
    Gut 48:816-20. 2001
    ..We further analysed the mortality statistics to determine which anatomical subcategories were involved...
  41. ncbi Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand
    S Sriamporn
    Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand
    Trop Med Int Health 9:588-94. 2004
    ..The cancer registry is an appropriate tool for disease monitoring in small areas...
  42. ncbi Intrahepatic bile ducts transport water in response to absorbed glucose
    Anatoly I Masyuk
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 283:C785-91. 2002
    ..Results support the hypothesis that the physiological significance of the absorption of biliary glucose by cholangiocytes is likely related to regulation of ductal bile formation...
  43. ncbi Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis
    Hong Joo Kim
    Division of Gastroenterology and Gastrointestinal Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 19:582-8. 2004
    ..The goal of the present study was to determine the possible roles and clinical significance of COX-2 expression in CC...
  44. ncbi Cholangiocarcinoma
    Konstantinos N Lazaridis
    Division of Gastroenterology and Hepatology, Center for the Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 128:1655-67. 2005
  45. ncbi Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT
    Jun Li
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    J Surg Oncol 98:438-43. 2008
    ..The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma...
  46. ncbi The aberrant expression of HLA-DR in intrahepatic bile ducts in patients with biliary atresia: an immunohistochemistry and immune electron microscopy study
    Jiexiong Feng
    Department of Pediatric Surgery, Children s Hospital of Zhejiang University, Hangzhou, China
    J Pediatr Surg 39:1658-62. 2004
    ..In this study, the authors evaluated the expression of HLA-DR in liver tissue of patients with BA to explore its role in the pathogenesis of this disease...
  47. ncbi Cholangiocarcinoma: morphologic classification according to growth pattern and imaging findings
    Jae Hoon Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 710, South Korea
    AJR Am J Roentgenol 181:819-27. 2003
  48. pmc Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases
    Tomoki Ebata
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 238:720-7. 2003
    ..To better determine the role of portal vein resection and its effect on survival, as well as to appreciate the impact of portal vein invasion on prognosis in hilar cholangiocarcinoma...
  49. ncbi Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy
    Alphonse E Sirica
    Division of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Medical College of Virginia Campus, Richmond, VA 23298 0297, USA
    Hepatology 41:5-15. 2005
    ....
  50. pmc Cholangiocarcinoma: modern advances in understanding a deadly old disease
    Harmeet Malhi
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Hepatol 45:856-67. 2006
    ..Future targeted therapies will depend on a better understanding of the cellular and molecular biology of cholangiocarcinomas...
  51. ncbi CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma
    Min Cheng Su
    Department of Pathology, Min Sheng General Hospital, 168 Ching Kuo Road, Taoyuan City, Taiwan, ROC
    Cancer Lett 235:34-9. 2006
    ..In a multivariant analysis, CD24 expression and tumor stage were independent prognostic factors. Our data suggest that CD24 expression in intrahepatic cholangiocarcinoma is a novel prognostic marker for intrahepatic cholangiocarcinoma...
  52. ncbi p53 Mutations in human cholangiocarcinoma: a review
    Shahid A Khan
    Liver Unit, St Mary s Campus, Hammersmith Hospital Campus, Faculty of Medicine, Imperial College, London, UK
    Liver Int 25:704-16. 2005
    ..The structure and function of p53 and its role in linking cancer to specific carcinogens by way of mutational signatures is reviewed. The findings of previous p53 studies and their relevance in human cholangiocarcinoma are summarised...
  53. ncbi Ursodeoxycholic acid in neonatal hepatitis and infantile paucity of intrahepatic bile ducts: review of a historical cohort
    M A Kotb
    Department of Pediatrics, Cairo University, El Mokatam, 11571 Cairo, Egypt
    Dig Dis Sci 54:2231-41. 2009
    ..418 (P = 0.040) and that of deterioration was 2.64 (P = 0.028). Ursodeoxycholic acid failed in management of this cohort of infants with nonsurgical cholestasis...
  54. ncbi Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts
    Andreas Weber
    Department of Gastroenterology, Technical University of Munich, Germany
    Eur J Radiol 72:412-7. 2009
    ..Major complications occurred in 17/419 patients (4%). Patients with nondilated intrahepatic bile ducts had significantly higher complication rates compared to patients with dilated intrahepatic bile ducts (14...
  55. ncbi Pathology of cholangiocarcinoma
    J H Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, 135 710 Seoul, Kangnam Ku, Korea
    Abdom Imaging 29:540-7. 2004
  56. ncbi Anatomic variations in intrahepatic bile ducts in a north Indian population
    Vijay Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 23:e58-62. 2008
    In the present study, we described the anatomical variations in the branching patterns of intrahepatic bile ducts (IHD) and determined the frequency of each variation in north Indian patients. There are no data from India.
  57. ncbi Impact of pretreatment cholinesterase level on survival of inoperable intrahepatic or hepatic-hilar carcinomas treated with three-dimensional conformal radiotherapy
    Yasushi Hamamoto
    Department of Radiology, Sikoku Cancer Center, 13 Horinouchi, Matsuyama City, Ehime 790 0007, Japan
    Radiat Med 22:316-23. 2004
    ....
  58. ncbi Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma
    Carlos U Corvera
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 201:862-9. 2005
    ..Nontraumatic inflammatory hilar strictures are uncommon, but are known to mimic malignancy. This study examines the clinical and pathologic features of benign idiopathic strictures...
  59. ncbi A review and update on cholangiocarcinoma
    Matthew J Olnes
    Department of Internal Medicine, Johns Hopkins Bayview Medical Center and Johns Hopkins School of Medicine, Baltimore, MD, USA
    Oncology 66:167-79. 2004
    ..Particular focus is on recent studies into the cellular and molecular pathogenesis of the disease, recent chemotherapy trials, and newer methods of staging and screening for this devastating malignancy...
  60. ncbi Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
    L C Pederson
    Department of Surgery, University of Alabama at Birmingham, 35294, USA
    Cancer Res 57:4325-32. 1997
    ..Radiobiological survival curve parameters confirmed an interactive cytotoxic effect when viral infection and prodrug therapy were combined with external beam radiation exposure. (ABSTRACT TRUNCATED)..
  61. ncbi The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma
    Byung Kyu Park
    Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Am J Clin Oncol 29:138-42. 2006
    ..Lymphatic spread is a key prognostic factor in intrahepatic cholangiocarcinoma (ICC). We studied the expression of VEGF-C in ICC tissues to clarify its clinicopathologic significance...
  62. ncbi Endoscopic management of liver abscesses and cysts that communicate with intrahepatic bile ducts
    B C Sharma
    Department of Gastroenterology, Rm No 203, 2nd Floor Academic Block, GB Pant Hospital, New Delhi 110002, India
    Endoscopy 38:249-53. 2006
    The formation of a communication between liver abscesses or cysts and intrahepatic bile ducts is an uncommon cause of significant bile leak. Surgical management of biliary fistulas is associated with high morbidity and mortality...
  63. ncbi Matrix proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's disease
    Mitsue Yasoshima
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Pathol 217:442-51. 2009
    ..Immunostaining showed that basement membrane expression of laminin and type IV collagen around intrahepatic bile ducts was degraded in CHF, Caroli's disease, and the PCK rats...
  64. ncbi Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study
    Tae Y Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Am J Gastroenterol 103:1716-20. 2008
    ..Several studies have suggested that hepatitis C virus (HCV) infection may play a role in the development of ICC, whereas the role of hepatitis B virus (HBV) infection is less clear...
  65. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ..the presence of mitochondria in virtually all nucleated cells, the destruction in PBC is limited to small intrahepatic bile ducts. The reasons for this tissue specificity remain unknown, although biliary epithelial cells (BECs) ..
  66. ncbi Cholangiocarcinoma
    Stefania Mosconi
    Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy
    Crit Rev Oncol Hematol 69:259-70. 2009
    ....
  67. ncbi Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells
    Shinji Shimoda
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatology 47:958-65. 2008
    Primary biliary cirrhosis (PBC) is characterized by the highly selective autoimmune injury of small intrahepatic bile ducts, despite widespread distribution of mitochondrial autoantigens...
  68. ncbi Early detection and treatment of cholangiocarcinoma
    G J Gores
    Mayo Clinic, Foundation, and Medical School, Rochester, MN 55905, USA
    Liver Transpl 6:S30-4. 2000
    ..Outcomes are optimized by using preoperative radiation and chemotherapy and ensuring the absence of metastases by an exploratory laparotomy...
  69. ncbi Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 27:1174-84. 2007
    ....
  70. ncbi Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study
    N Chalasani
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 31:7-11. 2000
    ..The indices of severity of liver disease were not associated with CCA in patients with PSC. Serum CA 19-9 appeared to have good ability to discriminate PSC patients with and without CCA...
  71. ncbi The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma
    K Sugimachi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hepatol 35:74-9. 2001
    ..CONCLUSIONS: Overexpression and gene amplification of cyclin D1 are frequent and contribute to dedifferentiation and cellular proliferative activity of ICCs, and overexpression also indicates a poor prognosis for patients with ICC...
  72. ncbi Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP
    Gene D Lesage
    Department of Medicine, Scott and White Hospital, and The Texas A and M University System HSC, COM, Temple, TX 76504, USA
    Hepatology 40:1116-27. 2004
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  73. pmc Surgical anatomy of the bile ducts at the hepatic hilum as applied to living donor liver transplantation
    Masayuki Ohkubo
    Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 239:82-6. 2004
    ..To evaluate anatomic variations of the biliary tree as applied to living donor liver transplantation...
  74. ncbi [Surgical therapy of hilar cholangiocarcinoma]
    H Lang
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen
    Chirurg 77:325-34. 2006
    ..The increasing experience with living donor transplantation and recent advances in neoadjuvant tumor therapy may lead to renewed discussion of liver transplantation in hilar cholangiocarcinoma...
  75. ncbi Liver transplantation for hilar cholangiocarcinoma: a German survey
    G M Kaiser
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Universitatsklinikum Essen, Germany
    Transplant Proc 40:3191-3. 2008
    ..The present study reports a German survey addressing outcomes in nonselected historical series of liver transplantation (OLT) for hilar cholangiocarcinoma (HL)...
  76. ncbi Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance
    Di Tang
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565 0871, Osaka, Japan
    Oncol Rep 15:525-32. 2006
    ..Although TSP-1 may increase intrahepatic CCC metastases, neither MVD levels nor the expression of VEGF, Ang-1, or Ang-2 was associated with clinicopathological factors and prognosis...
  77. ncbi Expression and clinical significance of the erbB family in intrahepatic cholangiocellular carcinoma
    Y Ito
    Department of Surgery, Osaka Seamen's Insurance Hospital, Japan
    Pathol Res Pract 197:95-100. 2001
    ....
  78. ncbi Long-term results following resectional surgery for Klatskin tumors. A twenty-year personal experience
    N J Lygidakis
    Department of Surgical Oncology, Athens Medical Center, Apollonion Hospital, Athens, Greece
    Hepatogastroenterology 48:95-101. 2001
    ....
  79. ncbi Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University School of Medicine, Seiryo, Aobaku, Sendai, Japan
    Liver Int 23:449-59. 2003
    We have shown that large and small cholangiocytes, which reside primarily in large and small intrahepatic bile ducts, respectively, have different functions and responses to injuries...
  80. ncbi Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines
    Gao song Wu
    Department of General Surgery, Tongji Hospital, 1095 Jiefang Road, Wuhan, 430030, Hubei Province, China
    World J Gastroenterol 9:1302-6. 2003
    ..To evaluate the roles and mechanisms of celecoxib in inducing proliferation inhibition and apoptosis of human cholangiocarcinoma cell lines...
  81. ncbi Regulation of cholangiocyte bicarbonate secretion
    N Kanno
    Department of Internal Medicine, Scott and White Hospital and Texas A and M University System Health Science Center, College of Medicine, TX 76504, USA
    Am J Physiol Gastrointest Liver Physiol 281:G612-25. 2001
    ..by which secretin stimulates ductal secretion, we discuss the heterogeneous responses of different-sized intrahepatic bile ducts to gastrointestinal hormones. Furthermore, we outline the role of a number of cooperative factors (e.g...
  82. ncbi Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma--a study of 51 cases from a low-endemicity area
    J Kaczynski
    Department of Medicine, , Sahlgren's University Hospital, Ostra, Sweden
    Acta Oncol 37:77-83. 1998
    ..The most common histological features were tubular pattern of growth (82%) and abundant fibrous stroma. Metastases were particularly associated with the lymph nodes (41%), skeleton (26%) and lungs (16%)...
  83. ncbi Knockout of alpha-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice
    Shannon S Glaser
    Department of Medicine, Scott and White Hospital, The Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76504, USA
    Lab Invest 87:914-26. 2007
    ..In conclusion, sensory innervation of the liver and biliary expression of alpha-CGRP play an important role in the regulation of cholangiocyte proliferation during cholestasis...
  84. ncbi Is a raised CA 19-9 level diagnostic for a cholangiocarcinoma in patients with no history of sclerosing cholangitis ?
    Abraham R John
    Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Dig Surg 23:319-24. 2006
    ..The aim of this study is to assess the role of CA 19-9 in patients with a cholangiocarcinoma without primary sclerosing cholangitis...
  85. ncbi Scavenger cells with gram-positive bacterial lipoteichoic acid infiltrate around the damaged interlobular bile ducts of primary biliary cirrhosis
    K Tsuneyama
    Department of Pathology (II, School of Medicine, Kanazawa University, Japan
    J Hepatol 35:156-63. 2001
    ..Such LTA may be involved in the development and progression of portal tract lesions, particularly bile duct lesions, in PBC...
  86. ncbi Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
    G Y Gwak
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, South Korea
    J Cancer Res Clin Oncol 131:649-52. 2005
    ..The response-predicting mutations in the tyrosine kinase domain of EGFR gene have recently been detected in non-small cell lung cancers. This study was, therefore, to investigate if these mutations are also found in cholangiocarcinomas...
  87. ncbi Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Dig Dis Sci 46:2166-72. 2001
    ..aims of this study were to determine the possible alteration of mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas and to try to predict whether or not hepatolithiasis has a predisposition to ..
  88. ncbi Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a hospital-based case-control study
    Yasser H Shaib
    The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA
    Am J Gastroenterol 102:1016-21. 2007
    ..We evaluated hepatitis C virus (HCV), hepatitis B virus (HBV), and liver cirrhosis as risk factors for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC)...
  89. ncbi Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    Kumiko Nakazawa
    Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
    J Pathol 206:356-65. 2005
    ..4%), was not associated with gene amplification. It is proposed that the new adjuvant chemotherapies could be directed to carcinomas of the biliary tract in which ErbB-2 and EGFR are overexpressed...
  90. ncbi Long isoform of prolactin receptor predominates in rat intrahepatic bile ducts and further increases under obstructive cholestasis
    R L Bogorad
    Laboratory of Endocrinology, Faculty of Biology, Lomonosov Moscow State University, Vorob ev Hills, 119992, Moscow, Russian Federation
    J Endocrinol 188:345-54. 2006
    ..From these data, the actions of prolactin on liver are anticipated to exhibit strong cell-type specificity in both normal and pathological conditions...
  91. ncbi Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells
    Jung Hwan Yoon
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110 744, South Korea
    J Hepatol 41:808-14. 2004
    ..However, the characteristics of EGFR signaling in cholangiocarcinoma cells have not been characterized. Thus, we attempted to more fully characterize EGF/EGFR signaling in human cholangiocarcinoma cells...
  92. ncbi A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:1198-203. 2006
    ..In conclusion, the rates of HCC and ICC approximately doubled between 1976 and 2000. Trends by age, gender, ethnicity, and birth cohort suggest that heterogeneity exists in the factors influencing these rates...
  93. ncbi The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ..Furthermore, embryonic Foxm1b -/- livers did not develop intrahepatic bile ducts, and these presumptive biliary hepatoblasts failed to express either biliary cytokeratins or nuclear ..
  94. ncbi Resectability and prognostic factors after resection of hilar cholangiocarcinoma
    M Abdel Wahab
    Gastroenterology Center, Mansoura University, Egypt
    Hepatogastroenterology 53:5-10. 2006
    ..Hilar cholangiocarcinoma, still a challenging problem for surgeons and resectional surgery, is the treatment of choice for long-term survival. In this study we tried to evaluate different prognostic factors after resection...
  95. ncbi Akt expression may predict favorable prognosis in cholangiocarcinoma
    Milind M Javle
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Gastroenterol Hepatol 21:1744-51. 2006
    ..The aim of this clinicopathological study was to investigate the overexpression and co-expression of EGFR and related signaling proteins in cholangiocarcinoma and explore their relationship to clinical outcome...
  96. ncbi Preoperative biliary drainage for hilar cholangiocarcinoma
    Hiroyuki Maguchi
    Center for Gastroenterology, Teine Keijinkai Hospital, 1 jo 12 chome, Maeda, Sapporo, 006 8555, Japan
    J Hepatobiliary Pancreat Surg 14:441-6. 2007
    ..ENBD needs to be converted to PTBD in patients with segmental cholangitis, those with a prolonged need for drainage, or when the extent of longitudinal tumor extension is not sufficiently well characterized...
  97. pmc Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
    D Yoshikawa
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 98:418-25. 2008
    ..89; 95% CI, 1.05-3.39, P=0.0335) in IHCC. These results suggest that EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma...
  98. ncbi Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinoma
    George Pan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Oncol 31:843-50. 2007
    ..These findings provide a potential unifying molecular mechanism for modulating tumorigenesis via Fas/FasL expression...
  99. ncbi Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma
    Shusaku Ohira
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 56:381-9. 2006
    ..In conclusion, local mutual influence of TGF-beta1 secreted from carcinoma cells and SDF-1 expressed by stromal fibroblasts may be involved in invasion of CC cells...
  100. ncbi Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)
    Banchob Sripa
    Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    World J Gastroenterol 11:3392-7. 2005
    ..To establish and characterize a new cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand...
  101. ncbi Current approaches to the diagnosis and treatment of cholangiocarcinoma
    Santosh B Reddy
    Department of Internal Medicine, Scott and White Memorial Hospital and Clinic, Texas A and M University Health Science Center, 2401 South 31st Street, Temple, TX 76508, USA
    Curr Gastroenterol Rep 8:30-7. 2006
    ..Although surgical resection can be curative, many patients with cholangiocarcinoma are diagnosed at an advanced stage when only palliative approaches can be used. Photodynamic therapy is emerging as a useful modality...

Research Grants60

  1. Pathophysiology of cholangiocyte responses to microbial pathogens
    STEVEN P O'HARA; Fiscal Year: 2013
    ..of cell and molecular biology to understand the role of cholangiocytes, the epithelial cells lining intrahepatic bile ducts, in health and disease...
  2. Mechanosensitive Signaling and Cholangiocyte Secretion
    Andrew P Feranchak; Fiscal Year: 2013
    ..responsible for regulated transport by cholangiocytes, the epithelial cells that line the lumen of intrahepatic bile ducts and contribute importantly to the volume and composition of bile...
  3. Formation of bile ducts in three dimensional culture
    Keith E Mostov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The branching tree of intrahepatic bile ducts is lined by a monolayer of epithelial cells, known as cholangiocytes...
  4. REGULATION OF SECRETION BY BILE DUCT EPITHELIAL CELLS
    JOHN GREGORY FITZ; Fiscal Year: 2012
    ..mechanisms responsible for secretion by cholangiocytes, the epithelial cells that line the lumen of intrahepatic bile ducts and account for ~40% of bile volume in man...
  5. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2001
    ..biliary cirrhosis (PBC) is an autoimmune disease that primarily affects women and includes destruction of intrahepatic bile ducts and antimitochondrial antibodies (AMAs)...
  6. CLINICAL SIGNIFICANCE OF NOVEL PBC AUTOANTIBODIES
    Donald Bloch; Fiscal Year: 2001
    ..from the application) Primary biliary cirrhosis (PBC) is an autoimmune disease that predominantly affects intrahepatic bile ducts. As with many other autoimmune diseases, the vast majority of patients with PBC are women and the ..
  7. FETAL BILIARY MALFORMATIONS: INDUCTION AND PREVENTION
    M Thaler; Fiscal Year: 1980
    ..acids is overwhelmed by large dietary intakes of lithocholate by pregnant rats, a permanent lesion of the intrahepatic bile ducts is produced in newborns, associated with chronic cholestasis...
  8. BILE ACID MODULATION OF BILE DUCT SECRETION AND GROWTH
    Gene D Lesage; Fiscal Year: 2010
    ..We continue to focus on bile acid interactions with cholangiocytes, the epithelial cells lining intrahepatic bile ducts, because of the development of new hypotheses and techniques regarding the regulation of bile acid ..
  9. ROLE OF CD40-CD40 LIGAND IN PRIMARY BILIARY CIRRHOSIS
    MARLYN MAYO; Fiscal Year: 2003
    ..is a chronic autoimmune liver disease characterized by inflammatory destruction of small and medium sized intrahepatic bile ducts, leading to cholestasis, then fibrosis, cirrhosis, and its complications...
  10. Localized Water Influx During Cryptosporidium Invasion
    STEVEN O HARA; Fiscal Year: 2009
    ..of cell and molecular biology to understand the role of cholangiocytes, the epithelial cells lining intrahepatic bile ducts, in health and disease...
  11. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006
    PBC is an autoimmune liver disease characterized by obstruction of intrahepatic bile ducts and high titer antimitochondrial autoantibodies (AMA). The predominant autoantigen is PDC-E2...
  12. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2008
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. [unreadable] [unreadable] [unreadable]..
  13. PI3K in LPS-induced coagulation and inflammation
    James Luyendyk; Fiscal Year: 2006
    ..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. [unreadable] [unreadable] [unreadable]..
  14. Occult Hepatitis B
    Michael Torbenson; Fiscal Year: 2007
    ..abstract_text> ..
  15. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  16. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..autoimmune disease characterized by antimito- chondrial antibodies and progressive destruction of intrahepatic bile ducts. There has not been an animal model of PBC and studies are dependent on human clinical specimens, a ..
  17. STEM CELLS AND HEPATOCARCINOGENESIS
    Stewart Sell; Fiscal Year: 2009
    ..Knowledge of the cellular origin of cancer is critical for understanding how cancer evolves and for developing prevention strategies. ..
  18. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. The Role of the Notch Pathway in Bile Duct Development
    KATHLEEN MARY LOOMES; Fiscal Year: 2010
    ..We will assess their response to defined stimuli, and rescue the phenotype by transfecting with activated Notch ..
  20. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  21. MRI Evaluation of Acute Renal Transplant Dysfunction
    Vivian Lee; Fiscal Year: 2008
    ..At its conclusion, our study has a high likelihood of showing that functional MR renography for differentiating intrinsic renal diseases, will be an accurate tool for acute renal transplant dysfunction. ..
  22. STEM CELLS AND AGING
    Stewart Sell; Fiscal Year: 2008
    ..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
  23. Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver Biology
    Susanne Keiding; Fiscal Year: 2010
    ..This will lead to improved diagnosis and treatment of the large groups of patients with liver disease and cancer in the liver. ..
  24. Betaglycan as a modulator of TGF-beta signaling in hepatoma
    Rebecca Wells; Fiscal Year: 2008
    ..They will also greatly increase our understanding of TGF-beta signaling in general, and will pave the way for in vivo studies of beta glycan. ..
  25. Genetic Analysis of Zebrafish Biliary Mutants
    Randolph Matthews; Fiscal Year: 2008
    ..These studies in zebrafish may provide clues as to biliary development in mammals and to genetic contributions to cholestatic diseases in humans [unreadable] [unreadable]..
  26. Dissecting the Aggregation of AMA in Families of PBC Patients
    Konstantinos Lazaridis; Fiscal Year: 2008
    ..If successful, our effort will shed light toward better understanding of the genetic predisposition to PBC. [unreadable] [unreadable]..
  27. Lymphocyte recruitment in alcoholic hepatitis
    David Adams; Fiscal Year: 2009
    ..abstract_text> ..
  28. Regulation of Bile Ductular Proliferation
    JONATHAN DRANOFF; Fiscal Year: 2009
    ..We anticipate that the results of these proposed experiments will lead to novel pharmacologic approaches for the regulation of bile ductular proliferation in biliary cirrhosis. ..
  29. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  30. Listeria Monocytogenes to Treat Hepatic Metastases
    Richard Schulick; Fiscal Year: 2009
    ..Specific Aim 4: Define the role of dendritic cells in the priming and targeting of the immune response. ..
  31. Wnt Signaling in IBD-Related Colon Cancer
    RANDALL HOLCOMBE; Fiscal Year: 2005
    ..The precise effects of FIPs on Wnt signaling will be defined in vitro, with attention to the potentially disparate responses of different, specific, Fz receptor subtypes. ..
  32. PARACRINE REGULATION OF BILE DUCT SECRETION BY ATP
    JONATHAN DRANOFF; Fiscal Year: 2004
    ..The Yale School of Medicine Department of Internal Medicine has pledged that the candidate will have extensive protected research time and excellent resources for the duration of the award. ..
  33. NTPDase2 expression and function in the liver
    JONATHAN DRANOFF; Fiscal Year: 2005
    ..The ectonucleotidase NTPDase2 was found to be expressed in portal fibroblasts (PF) surrounding intrahepatic bile ducts, which provides a likely explanation for the selective hydrolysis of nucleotides at the basolateral ..
  34. COMPREHENSIVE MR EVALUATION OF RENOVASCULAR DISEASE
    Vivian Lee; Fiscal Year: 2003
    ....
  35. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..BA) appears to result from a chronic, progressive inflammatory mediated destruction of extrahepatic and intrahepatic bile ducts, leading some to call it "infantile obliterative cholangiopathy"...
  36. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2006
    ..abstract_text> ..
  37. THE ROLE OF NOTCH SIGNALING IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..abstract_text> ..
  38. Immunologic Mechanism/Destruction/Biliary Artesia
    Cara Mack; Fiscal Year: 2006
    ..cholangiopathy of infancy that leads to fibrosis and obliteration of both the extrahepatic and intrahepatic bile ducts. The immune response appears to be the key player in the ongoing destruction of the bile ducts...
  39. Magnetic Resonance Renography:Validation Studies
    Vivian Lee; Fiscal Year: 2003
    ..abstract_text> ..
  40. A Phase 1 Study of CCI-779 in Combination with Imatnib *
    RANDALL HOLCOMBE; Fiscal Year: 2006
    ..Since deregulated kinase activity is known to contribute to a wide range of malignancies, these studies will have applicability to cancer therapy in general. [unreadable] [unreadable]..
  41. AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICE
    Stewart Sell; Fiscal Year: 2002
    ..These studies should lead to an understanding of how each of these risk factors affect hepatocyte proliferation and how these effects contribute to AFB1 hepatocarcinogenesis. ..
  42. Volume Regulatory Pathways in Cystic Fibrosis Mice
    Won Kyoo Cho; Fiscal Year: 2003
    ..abstract_text> ..
  43. Rare Liver Disease Network
    Ronald Sokol; Fiscal Year: 2005
    ..The RLDN will be a full partner in the Rare Diseases Clinical Research Network and will participate collaboratively with the other Clinical Research Centers and the Data and Technology Coordinating Center. ..
  44. SIGNALING MOLECULES IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..abstract_text> ..
  45. BILIARY SECRETORY PATHWAYS IN CYSTIC FIBROSIS
    Won Kyoo Cho; Fiscal Year: 2003
    ..abstract_text> ..
  46. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga P Chalasani; Fiscal Year: 2010
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
  47. Molecular response of bile duct cell to bile duct injury
    Ai Xuan Holterman; Fiscal Year: 2005
    ..Bile duct specific target gene mRNA and protein expression will be assessed and the effect on the development of biliary fibrosis will be determined. ..
  48. GM-CSF Enhanced Colorectal Cancer Tumor Vaccine Program
    Richard Schulick; Fiscal Year: 2008
    ..abstract_text> ..
  49. OXIDANT HEPATIC INJURY IN CHOLESTASIS
    Ronald Sokol; Fiscal Year: 2005
    ....
  50. Ariol SL-50 Workstation and Review Stations
    MARY WASHINGTON; Fiscal Year: 2005
    ..An additional benefit is the ease of data sharing among groups, facilitating interactions among investigators and promoting inter-SPORE collaborations. ..
  51. Targeting AKT as a novel therapy in pancreatic cancer
    Richard Bold; Fiscal Year: 2007
    ..These results will provide mechanistic as well as pre-clinical data in support of our hypothesis and will allow for the development of novel therapy of human pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  52. Foxm1b and HNF-6 regulation of liver injury response
    Ai Xuan Holterman; Fiscal Year: 2006
    ..The potential of salvaging failed liver, improving the quality of life or extending survival of patients with liver insufficiency using these therapeutic strategies is far reaching. ..
  53. Genetic Epidemiology of Primary Biliary Cirrhosis
    Konstantinos Lazaridis; Fiscal Year: 2008
    ..abstract_text> ..
  54. Molecular and Functional Analysis of CASK in Epithelia
    Zenta Walther; Fiscal Year: 2005
    ..We anticipate these studies will shed considerable light on the molecular interactions of CASK, its role in growth factor complex assembly and/or signal transduction, and its potential involvement in tumorigenesis. ..
  55. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
    ..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
  56. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
    ..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
  57. Identification of Serum Markers of Liver Fibrogenesis/ Fibrolysis by Proteomics
    Detlef Schuppan; Fiscal Year: 2008
    ..Adaptation to the human proteome and prospective validation shall allow noninvasive monitoring of fibrosis progression and regression in patients with liver diseases. [unreadable] [unreadable] [unreadable]..
  58. Mouse Models for Celiac Disease
    Detlef Schuppan; Fiscal Year: 2007
    ..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..