Genomes and Genes
Summary: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
Publications294 found, 100 shown here
- Incidence of adenocarcinoma among patients with Barrett's esophagusFrederik Hvid-Jensen
Department of Surgical Gastroenterology L, Aarhus University Hospital, Aarhus, Denmark
N Engl J Med 365:1375-83. 2011Accurate population-based data are needed on the incidence of esophageal adenocarcinoma and high-grade dysplasia among patients with Barrett's esophagus.
- In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopyRalf Kiesslich
Medical Clinic, Johannes Gutenberg University Mainz, Germany
Clin Gastroenterol Hepatol 4:979-87. 2006..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
- Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)Paul Swain
Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
Gastrointest Endosc 71:1290-3. 2010..Remote manipulation of wireless capsule endoscopes might improve diagnostic accuracy and facilitate therapy...
- Foxp2 and Foxp1 cooperatively regulate lung and esophagus developmentWeiguo Shu
Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
Development 134:1991-2000. 2007....
- Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagusKenneth K Wang
Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
Am J Gastroenterol 103:788-97. 2008
- Evaluation of oesophageal mucosa integrity by the intraluminal impedance techniqueRicard Farre
Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
Gut 60:885-92. 2011..Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man...
- A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardiaChristopher J Peters
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
Gastroenterology 139:1995-2004.e15. 2010..Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma...
- Durability of radiofrequency ablation in Barrett's esophagus with dysplasiaNicholas J Shaheen
Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
Gastroenterology 141:460-8. 2011..ablation (RFA) can eradicate dysplasia and intestinal metaplasia in patients with dysplastic Barrett's esophagus (BE), and reduce rates of esophageal adenocarcinoma...
- Esophageal acid exposure decreases intraluminal baseline impedance levelsBoudewijn F Kessing
Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, The Netherlands
Am J Gastroenterol 106:2093-7. 2011..The aim of this study was to investigate the baseline impedance in GERD patients, on and off proton pump inhibitor (PPI), and in healthy controls...
- Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopyMichael B Wallace
Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
Gastrointest Endosc 72:19-24. 2010..Confocal laser endomicroscopy (CLE) is a rapidly emerging method for in vivo imaging of the GI tract...
- Confocal laser scanning fluorescence microscopy for in vivo determination of microvessel density in Barrett's esophagusV Becker
Department of Medicine II, Technical University of Munich, Munich, Germany
Endoscopy 40:888-91. 2008Angiogenesis has been reported to be an essential step in the progression of cancers arising from Barrett's esophagus. Confocal laser scanning microscopy (CLM) has the potential to perform in vivo microscopy to detect angiogenesis and ..
- Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumorsG Bahrenberg
Institut fur Pharmakologie und Toxikologie, RWTH Aachen, Aachen, D 52057, Germany
Biochem Biophys Res Commun 275:783-8. 2000..Furthermore, PSCA mRNA was highly abundant in normal esophagus and stomach, but was undetectable in esophageal or gastric tumors...
- Probe-based confocal laser endomicroscopy compared with standard four-quadrant biopsy for evaluation of neoplasia in Barrett's esophagusM Bajbouj
II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
Endoscopy 42:435-40. 2010Surveillance of Barrett's esophagus includes endoscopic inspection with biopsy of suspicious lesions followed by four-quadrant biopsy of the remaining mucosa...
- Endoscopic submucosal dissection of esophageal squamous cell neoplasmsMitsuhiro Fujishiro
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Clin Gastroenterol Hepatol 4:688-94. 2006..Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus.
- Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead?Robert H Riddell
Mount Sinai Hospital, Toronto, Ontario, Canada
Am J Gastroenterol 104:2588-94. 2009The definition of Barrett's esophagus (BE) varies worldwide, particularly with regard to the need to identify goblet cells in esophageal biopsies in order to diagnose this condition...
- Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cellsFrancesca Milano
Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Gastroenterology 132:2412-21. 2007Barrett's esophagus (BE) is a metaplastic condition in which normal squamous esophageal epithelium is replaced by columnar epithelium...
- Achalasia: a new clinically relevant classification by high-resolution manometryJohn E Pandolfino
Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
Gastroenterology 135:1526-33. 2008..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
- Etiology and pathogenesis of achalasia: the current understandingWoosuk Park
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Gastroenterol 100:1404-14. 2005..Current evidence suggests that the initial insult to the esophagus, perhaps a viral infection or some other environmental factor, results in myenteric plexus inflammation...
- Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagusDominique P Coco
Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Surg Pathol 35:45-54. 2011Recent morphologic and molecular evidence suggests that dysplasia in Barrett esophagus (BE) begins in the bases of the crypts [crypt dysplasia (CD)] and progresses with time to involve the upper portions of the crypts and surface ..
- Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasiaDavid H Wang
Graduate Training Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Gastroenterology 138:1810-22. 2010The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown...
- Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patientsDanny Yakoub
Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, United Kingdom
Cancer Res 70:9129-36. 2010..This indicates that metabolic profiling of tissue can potentially play a role in the surveillance of cancer by reporting on the phenotypic consequences of field cancerization...
- MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkersThomas X Lu
Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
J Allergy Clin Immunol 129:1064-75.e9. 2012..The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored...
- Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagusBeau A Standish
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada
Gastrointest Endosc 66:326-33. 2007..DOCT) is an imaging modality that allows assessment of the microvascular response during photodynamic therapy (PDT) and may be a powerful tool for treatment monitoring/optimization in conditions such as Barrett's esophagus (BE).
- Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteinsXin Chen
Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
Am J Physiol Gastrointest Liver Physiol 301:G203-9. 2011..In conclusion, acidic bile salts disrupted the squamous epithelial barrier function partly by modulating the amounts of claudin-1 and claudin-4. These results provide new insights for understanding the role of TJ proteins in esophagitis...
- Perception of dysphagia: lack of correlation with objective measurements of esophageal functionA Lazarescu
Centre for Gastroenterological Research, KU Leuven, Leuven, Belgium
Neurogastroenterol Motil 22:1292-7, e336-7. 2010....
- Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layersTadayuki Oshima
Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
Lab Invest 92:22-31. 2012..These localization patterns are similar to those in the human esophagus. On day 7 under ALI culture, TJ proteins were detected in the superficial layers with functional properties, ..
- Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagusKaterina Dvorak
Department of Cell Biology and Anatomy, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
Clin Cancer Res 13:5305-13. 2007The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear...
- History, molecular mechanisms, and endoscopic treatment of Barrett's esophagusStuart Jon Spechler
VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA
Gastroenterology 138:854-69. 2010..Association Institute's medical position statement and technical review on the management of Barrett's esophagus, which will be published in the near future...
- Cdx2 as a marker of epithelial intestinal differentiation in the esophagusRoy W Phillips
Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
Am J Surg Pathol 27:1442-7. 2003The histologic diagnosis of Barrett's esophagus requires the presence of goblet cells, but this finding may not be the earliest indicator of intestinal metaplasia...
- Induction of intestinalization in human esophageal keratinocytes is a multistep processJianping Kong
Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
Carcinogenesis 30:122-30. 2009Barrett's esophagus (BE) is the replacement of normal squamous esophageal mucosa with an intestinalized columnar epithelium. The molecular mechanisms underlying its development are not understood...
- Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitisGeorg Dimcevski
Department of Medical Gastroenterology, Haukeland University Hospital, Bergen, Norway
Pancreas 35:22-9. 2007..We, therefore, aimed at exploring the pain mechanisms in chronic pancreatitis (CP) using a multimodal and multitissue stimulation approach...
- Relevance of ineffective oesophageal motility during oesophageal acid clearanceM Simren
Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
Gut 52:784-90. 2003..Intraluminal impedance allows non-radiological monitoring of movement of oesophageal liquids...
- IL-5 promotes eosinophil trafficking to the esophagusAnil Mishra
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 168:2464-9. 2002Eosinophil infiltration into the esophagus occurs in a wide range of diseases; however, the underlying pathophysiological mechanisms involved are largely unknown...
- Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine modelT Ohki
Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Gut 55:1704-10. 2006..However, after aggressive ESD, a major complication that arises is postoperative inflammation and stenosis that can considerably affect the patient's quality of life...
- Mechanical ventilation guided by esophageal pressure in acute lung injuryDaniel Talmor
Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
N Engl J Med 359:2095-104. 2008....
- Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryosP Minoo
Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
Dev Biol 209:60-71. 1999..Failure in septation between the trachea and the esophagus in Nkx2...
- Bacterial biota in the human distal esophagusZhiheng Pei
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 101:4250-5. 2004The esophagus, like other luminal organs of the digestive system, provides a potential environment for bacterial colonization, but little is known about the presence of a bacterial biota or its nature...
- Morphogenesis of the trachea and esophagus: current players and new roles for noggin and BmpsJianwen Que
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Differentiation 74:422-37. 2006..folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus. Defects in foregut morphogenesis underlie the constellation of human birth defects known as esophageal atresia (..
- High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometryM Fox
Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
Neurogastroenterol Motil 16:533-42. 2004..ii) The clinical value of HRM was assessed in a series of patients with endoscopy-negative dysphagia in whom conventional investigations had been non-diagnostic...
- MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagusDipen M Maru
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
Am J Pathol 174:1940-8. 2009Barrett's esophagus (BE)/Barrett's metaplasia (BM) is a recognized precursor of esophageal adenocarcinoma (EA) with an intermediary stage of dysplasia...
- Long-term clinical and pathologic response of Barrett's esophagus after antireflux surgeryJames M O'Riordan
University Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
Am J Surg 188:27-33. 2004The impact of antireflux surgery on outcome in Barrett's esophagus, in particular its effect on both the regression of metaplasia and the progression of metaplasia through dysplasia to adenocarcinoma, remains unclear...
- Radiofrequency ablation in Barrett's esophagus with dysplasiaNicholas J Shaheen
Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, CB 7080, Chapel Hill, NC 27599 7080, USA
N Engl J Med 360:2277-88. 2009Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma...
- Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch testsJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
Ann Allergy Asthma Immunol 95:336-43. 2005..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
- Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2Nan Gao
Department of Genetics, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Cell 16:588-99. 2009..We conclude that Cdx2 controls important aspects of intestinal identity and development, and that this function is largely independent of the enteric Hox code...
- Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factorsShinya Ohashi
Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 70:4174-84. 2010....
- Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cellsTong Liu
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
Carcinogenesis 28:488-96. 2007Caudal-related homeobox 2 (Cdx2) has been suggested as an early marker of Barrett's esophagus (BE), which is the premalignant lesion of esophageal adenocarcinoma (EAC)...
- Life isn't flat: taking cancer biology to the next dimensionKeiran S M Smalley
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
In Vitro Cell Dev Biol Anim 42:242-7. 2006..It is likely that the adoption of these and other 3D models will allow us to more closely re-create the behavior of the tumor in vivo which may lead to identifying better anticancer drug candidates at an earlier stage of development...
- Multiple fields may offer better esophagus sparing without increased probability of lung toxicity in optimized IMRT of lung tumorsOlivier Chapet
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 65:255-65. 2006..To evaluate whether increasing numbers of intensity-modulated radiation therapy (IMRT) fields enhance lung-tumor dose without additional predicted toxicity for difficult planning geometries...
- A unique esophageal motor pattern that involves longitudinal muscles is responsible for emptying in achalasia esophagusSu Jin Hong
Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, South Korea
Gastroenterology 139:102-11. 2010Achalasia esophagus is characterized by loss of peristalsis and incomplete esophagogastric junction (EGJ) relaxation...
- Trends in Barrett's esophagus diagnosis in Southern Europe: implications for surveillanceJavier Alcedo
Service of Digestive Diseases, Clínico Lozano Blesa Hospital, Institute of Health Sciences, CIBERehd, University of Zaragoza, Zaragoza, Spain
Dis Esophagus 22:239-48. 2009The incidence of Barrett's esophagus (BE) and esophageal adenocarcinoma has increased in Western countries in recent decades...
- The role of radiofrequency ablation in the management of Barrett's esophagusWilliam J Bulsiewicz
GI Outcomes Training Program, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Gastrointest Endosc Clin N Am 21:95-109. 2011..RFA) to be effective, safe, and well tolerated in the treatment of nondysplastic and dysplastic Barrett's esophagus (BE). The results found at academic medical centers have been reproduced in the community setting...
- Bile in the esophagus-model for a bile acid biosensorDhiren Nehra
Department of Upper GI Surgery, Epsom and St Helier University Hospital, Carshalton, Surrey, SM7 1LA, UK
J Gastrointest Surg 14:S6-8. 2010..This paper looks at a model for development of a biosensor for bile acid based on molecular imprinted polymers...
- Assessment of intraluminal impedance for the detection of pharyngeal bolus flow during swallowing in healthy adultsTaher I Omari
Department of Paediatrics, University of Adelaide, and Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Adelaide, South Australia
Am J Physiol Gastrointest Liver Physiol 290:G183-8. 2006..In contrast, in the upper esophageal sphincter (UES) and proximal esophagus, the timing of impedance recovery correlated well with the timing of clearance of the bolus tail...
- Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagusRicard Farre
Center for Gastroenterological Research, Catholic University Leuven, Belgium
Gut 59:164-9. 2010..We aimed to assess the effect of oesophageal perfusions with acid and weakly acidic solutions on 'exposed' and 'non-exposed' oesophageal mucosa and its relationship to symptoms in healthy subjects...
- Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus developmentM V Zinovyeva
Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Dis Esophagus 23:260-70. 2010..Here we directly compared gene expression profiles in human esophageal squamous cell carcinomas and in human fetal esophagus development...
- Criteria for assessing esophageal motility in laparoscopic adjustable gastric band patients: the importance of the lower esophageal contractile segmentPaul Robert Burton
Centre for Obesity Research and Education CORE, Monash Medical School, The Alfred Hospital, Commercial RD Prahran, 3181, Melbourne, Australia
Obes Surg 20:316-25. 2010..Recent combined video fluoroscopic and high-resolution manometric studies have identified important components of esophageal function in LAGB patients...
- Brain stem control of swallowing: neuronal network and cellular mechanismsA Jean
Laboratoire de Neurobiologie des Fonctions Vegetatives, Departement de Physiologie et Neurophysiologie, Faculté des Sciences et Techniques Saint Jérôme, Marseille, France
Physiol Rev 81:929-69. 2001..The mechanisms possibly involved in pattern generation and the possible flexibility of the swallowing central pattern generator are discussed...
- Detection of dysplasia in Barrett's esophagus with in vivo depth-resolved nuclear morphology measurementsNeil G Terry
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
Gastroenterology 140:42-50. 2011Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes...
- Reproducibility of esophageal high-resolution manometryA Bogte
Gastrointestinal Research Unit, Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
Neurogastroenterol Motil 23:e271-6. 2011..Until now, the reproducibility of these parameters has not been investigated...
- Manometric features of eosinophilic esophagitis in esophageal pressure topographyS Roman
Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
Neurogastroenterol Motil 23:208-14, e111. 2011..The aims of this study were to evaluate the esophageal pressure topography (EPT) findings in EoE and to compare them with controls and patients with gastro-esophageal disease (GERD)...
- Post-corrosive late complications in esophagus and stomach--role of the esophageal restAndon Chibisev
University Clinic for Toxicology, Clinical Centre, Skopje, Republic of Macedonia
Med Arh 64:320-3. 2010..cause severe chemical injuries of the upper gastrointestinal tract, the most common location being the esophagus and the stomach...
- Respiratory restriction and elevated pleural and esophageal pressures in morbid obesityNegin Behazin
Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol (1985) 108:212-8. 2010..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes...
- Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?Gerrit J M Hemmink
Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
Am J Gastroenterol 103:2446-53. 2008..Until now, it is unclear whether combined pH-impedance monitoring in these patients should be performed on or off PPI...
- A prospective study to compare a symptom-based reflux disease questionnaire to 48-h wireless pH monitoring for the identification of gastroesophageal reflux (revised 2-26-11)Brian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Am J Gastroenterol 106:1604-11. 2011..The aim of this study was to prospectively evaluate the association between GerdQ scores and 48-h wireless pH recording in patients studied either on or off acid suppression...
- Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal refluxClara M Loots
Academic Medical Centre, Amsterdam, The Netherlands
J Pediatr 154:248-52. 2009..To assess the additional yield of combined multichannel intraluminal pH-impedance (pH-MII) monitoring compared with standard pH monitoring on gastroesophageal reflux (GER) symptom associations in infants and children...
- The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissectionSatoru Hashimoto
Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan
Gastrointest Endosc 74:1389-93. 2011....
- Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transitionMinli Wang
USRA, Division of Life Sciences, Houston, TX 77058, USA
J Radiat Res 53:51-7. 2012....
- Foreign body ingestion in childrenMonte C Uyemura
Wray Rural Training Tract Family Medicine Residency Program, Wray, Colorado, USA
Am Fam Physician 72:287-91. 2005..Foreign bodies lodged in the esophagus should be removed endoscopically, but some small, blunt objects may be pulled out using a Foley catheter or ..
- Reflux events detected by pH-MII do not determine fundoplication outcomeRachel Rosen
Center for Motility and Functional Gastrointestinal Disorders, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Pediatr Gastroenterol Nutr 50:251-5. 2010..The aim of the study was to determine predictors of fundoplication outcome including acid and nonacid reflux burden...
- Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatmentAmir F Kagalwalla
Department of Pediatrics, Children s Memorial Hospital and Northwestern University, Chicago, IL, USA
J Allergy Clin Immunol 129:1387-1396.e7. 2012..Mechanisms underlying esophageal remodeling with subepithelial fibrosis in subjects with eosinophilic esophagitis (EoE) have not been delineated...
- Loss of manganese superoxide dismutase expression and activity in rat esophagus with external esophageal perfusionYan Li
Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Surgery 141:359-67. 2007..Thus, the aim of this study is to investigate the role of MnSOD expression and activity in rats with esophageal perfusion injury...
- Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagusLe Qiu
Biomedical Imaging and Spectroscopy Laboratory, Department of Obstetrics, Harvard University and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Nat Med 16:603-6, 1p following 606. 2010Esophageal cancer is increasing in frequency in the United States faster than any other cancer. Barrett's esophagus, an otherwise benign complication of esophageal reflux, affects approximately three million Americans and precedes almost ..
- Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapyClara M Loots
Department of Pediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
J Pediatr Gastroenterol Nutr 53:120-3. 2011..28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease...
- Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagusHejin P Hahn
Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 33:1006-15. 2009Barrett esophagus (BE) is defined by the presence of metaplastic esophageal columnar epithelium with goblet cells within endoscopically recognizable areas of the esophagus...
- Alcoholics show reduced telomere length in the oesophagusJunko Aida
Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
J Pathol 223:410-6. 2011..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
- Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagusRyu Ishihara
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
J Gastroenterol Hepatol 25:1410-5. 2010..The primary endpoint of the present study was to identify the significant NBI findings to diagnose esophageal mucosal high-grade neoplasia...
- Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophiliaPeter Ngo
Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
Am J Gastroenterol 101:1666-70. 2006Scattered eosinophils in the distal esophagus traditionally provide the hallmark for peptic esophagitis, but the upper limit of eosinophils and the longitudinal extent of peptic inflammation along the esophagus are unknown...
- Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardiaJantine W P M van Baal
Department of Cell Biology, University of Groningen, Groningen, The Netherlands
Cancer Res 66:11605-12. 2006The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that occur in Barrett's esophagus are poorly understood, this study aimed at ..
- Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinomaKen ichi Goda
Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
Gastrointest Endosc 65:36-46. 2007Barrett's esophagus with specialized intestinal metaplasia (SIM) from columnar-lined esophagus is difficult to distinguish with routine endoscopy.
- CT features of esophageal emergenciesCatherine A Young
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110, USA
Radiographics 28:1541-53. 2008..An awareness of the CT findings associated with the spectrum of acute esophageal disease facilitates the accurate and prompt diagnosis of esophageal emergencies and thereby contributes to a more successful outcome...
- The prognostic impact of O6-Methylguanine-DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinomaS Baumann
Institute for Pathology and Pathologic Anatomy, Technical University of Munich, Munich, Germany
Int J Cancer 119:264-8. 2006..In conclusion, MGMT hypermethylation in esophageal adenocarcinoma is a frequent event that is associated with loss of MGMT protein expression but not with patient's outcome...
- Non-biopsy detection of intestinal metaplasia and dysplasia in Barrett's esophagus: a prospective multicenter studyP Sharma
University of Kansas School of Medicine and Veterans Affairs Medical Center, Kansas City, MO, USA
Endoscopy 38:1206-12. 2006..magnification chromoendoscopy (MCE) for the detection of intestinal metaplasia and dysplasia/cancer in Barrett's esophagus. Our aims were to assess the ability of MCE to predict the histological diagnosis (non-biopsy detection), to ..
- A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardiaJantine W P M van Baal
Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
Gastroenterology 129:1274-81. 2005The metaplastic process in which the normal squamous epithelium of the distal esophagus is replaced by columnar-lined epithelium, known as Barrett's esophagus (BE), is poorly understood...
- Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagusWei Yuan Yu
Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK
Dev Biol 284:157-70. 2005..The results show that, in normal development, the squamous epithelium arises from the columnar epithelium by a direct conversion process...
- Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomasCharles A Fox
Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
Neoplasia 7:407-16. 2005Identification of biomarkers to recognize individuals with Barrett's esophagus (BE) predisposed to develop malignancy is currently a pressing issue...
- Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagusVladimir Ustiyan
Divisions of Pulmonary Biology, Perinatal Institute of the Cincinnati Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Dev Biol 336:266-79. 2009..mice died immediately after birth due to severe pulmonary hemorrhage and structural defects in arterial wall and esophagus. Although Foxm1 deletion did not influence SMC differentiation, decreased proliferation of SMC was found in ..
- NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional networkShinya Ohashi
Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 139:2113-23. 2010..However, the functional roles of Notch in esophageal squamous epithelial biology are unknown...
- Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trialD E Fleischer
Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Endoscopy 42:781-9. 2010The AIM-II Trial included patients with nondysplastic Barrett's esophagus (NDBE) treated with radiofrequency ablation (RFA). Complete eradication of NDBE (complete response-intestinal metaplasia [CR-IM]) was achieved in 98...
- Intensity-modulated radiotherapy for locally advanced non-small-cell lung cancer: a dose-escalation planning studyYolande Lievens
Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium
Int J Radiat Oncol Biol Phys 80:306-13. 2011..To evaluate the potential for dose escalation with intensity-modulated radiotherapy (IMRT) in positron emission tomography-based radiotherapy planning for locally advanced non-small-cell lung cancer (LA-NSCLC)...
- Clinical practice. Barrett's EsophagusStuart Jon Spechler
Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas 75216, USA
N Engl J Med 346:836-42. 2002
- Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesisAaron Goldman
Department of Cell Biology and Anatomy, Univ of Arizona, 1501 N Campbell Ave P O Box 245044, Tucson, AZ 85724, USA
Am J Physiol Gastrointest Liver Physiol 300:G292-302. 2011Barrett's esophagus (BE) is a premalignant condition, where normal squamous epithelium is replaced by intestinal epithelium. BE is associated with an increased risk of developing esophageal adenocarcinoma (EAC)...
- P53 and Ki-67 overexpression in gastroesophageal reflux disease--Barrett's esophagus and adenocarcinoma sequenceM Binato
Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil
Dis Esophagus 22:588-95. 2009..001 and P < 0.05). Our results indicate that overexpression of p53 and increased Ki-67 could be associated with the development and progression to ACE in patients with GERD...
- Safety and efficacy of endoscopic spray cryotherapy for Barrett's esophagus with high-grade dysplasiaNicholas J Shaheen
Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
Gastrointest Endosc 71:680-5. 2010Endoscopic ablation to treat Barrett's esophagus (BE) with high-grade dysplasia (HGD) is associated with a decreased incidence of esophageal adenocarcinoma. Endoscopic spray cryotherapy (CRYO) demonstrates promising preliminary data.
- Regulation of CDX2 expression in esophageal adenocarcinomaNadine Vaninetti
Department of Pathology, Dalhousie University, Halifax, NS, Canada
Mol Carcinog 48:965-74. 2009Reflux of acidic gastric contents and bile acids into the lower esophagus has been identified to have a central role in esophageal malignancy and is reported to upregulate caudal-related homologue 2 (CDX2), a regulatory gene involved in ..
- Intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil) after laparoscopic total gastrectomyOh Jeong
Department of Gastroenterologic Surgery, Chonnam National University Hwasun Hospital, 160, Ilsim Ri, Hwasun eup, Hwasun Gun, Jeollanam do, 519 809, Korea
Surg Endosc 23:2624-30. 2009..The authors report the newly developed reconstruction technique after LTG: intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil; Covidien, Mansfield, MA, USA)...
- Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosaAkashi Eda
Department of Internal Medicine, Jichi Medical School, Yakushiji, Kawachi, Tochigi 329 0438, Japan
J Gastroenterol 38:14-22. 2003..The present study was designed to examine the expression of CDX 1/2 in inflammatory esophageal mucosa with or without Barrett's epithelium...
- Analysis of component findings in 79 patients diagnosed with VACTERL associationBenjamin D Solomon
Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
Am J Med Genet A 152:2236-44. 2010..These findings have implications for both our understanding of VACTERL association and for the approach to research involving this condition...
- Neurocognitive processing of esophageal central sensitization in the insula and cingulate gyrusAdeyemi Lawal
Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Gastrointest Liver Physiol 294:G787-94. 2008..the neurocognitive processing in the cingulate and insular cortices to mechanical stimulation of the proximal esophagus following infusion of acid or phosphate buffer solution (PBS) into the esophagus...
- Deterioration of muscle function in the human esophagus with ageHans Gregersen
Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital, Aalborg, Denmark
Dig Dis Sci 53:3065-70. 2008..Esophageal motor function is traditionally studied by means of manometry and radiography. Distension of the esophagus with evaluation of active and passive mechanical parameters have become available during recent years...
- Prevalence and risk factors of Barrett's esophagus in patients undergoing endoscopy for upper gastrointestinal symptomsLi Shou Xiong
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong Province, China
J Dig Dis 11:83-7. 2010To investigate the prevalence of Barrett's esophagus (BE) and its risk factors in patients undergoing endoscopy for upper gastrointestinal symptoms in a Chinese tertiary referral medical center.
- Prevalence of Barrett's esophagus in the general population: an endoscopic studyJukka Ronkainen
Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden
Gastroenterology 129:1825-31. 2005Barrett's esophagus (BE) is associated with esophageal adenocarcinoma, the incidence of which has been increasing dramatically. The prevalence of BE in the general population is uncertain because upper endoscopy is required for diagnosis...
- The effects of glucose on central vagal brainstem circuitsKIRSTEEN NAIRN BROWNING; Fiscal Year: 2010..The receptive relaxation reflex is a classical, vagally-mediated reflex activated upon distension of the esophagus (during swallowing, for example) that induces gastric relaxation and suppression of motility, allowing the ..
- THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUSLarry Miller; Fiscal Year: 2006..and contraction of the CD in relationship to the LES, the compressive effect and forces of the CD on the distal esophagus, the role of the CD in antegrade movement of liquids and the role of the CD in induced relaxation of the GEJHPZ ..
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2009..take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2010..take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
- Modeling Neoplastic Progression in Barrett's EsophagusCarlo Maley; Fiscal Year: 2009..We propose to develop an agent-based computational model of neoplastic progression in Barrett's esophagus as a tool to study the dynamics of neoplastic progression and to integrate the genetic, pathological, clinical, ..
- Modeling Neoplastic Progression in Barrett's EsophagusJohn W Pepper; Fiscal Year: 2010..We propose to develop an agent-based computational model of neoplastic progression in Barrett's esophagus as a tool to study the dynamics of neoplastic progression and to integrate the genetic, pathological, clinical, ..
- Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinomaAnson W Lowe; Fiscal Year: 2010Barrett's esophagus is a premalignant lesion that increases the risk for esophageal adenocarcinoma...
- The Prevalence of Barrett's Esophagus in Patients with *Blair Jobe; Fiscal Year: 2004..improvement in survival of patients with cancers detected by routine endoscopic surveillance for Barrett's esophagus. In spite of these efforts, the majority of patients who develop esophageal adenocarcinoma are unaware of the ..
- Photoacoustic endoscopy of Barretts esophagusQIFA NO ZHOU; Fiscal Year: 2010..Parts of the gastrointestinal tract, including the esophagus, large intestine, and rectum, and/or parts of the cardiovascular system of animals, will be imaged in vivo or ex ..
- Micro RNA expression in esophageal adenocarcinomaVirginia Litle; Fiscal Year: 2007..Chronic reflux exposes the distal esophagus to stomach acid and bile causing irritation and inflammation...
- H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESISFritz Francois; Fiscal Year: 2007..The gastric inflammatory response to H. pylori may decrease acid production and reflux in the esophagus. Differences in the host mucosal inflammatory response to H...
- NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinomaWeibiao Cao; Fiscal Year: 2010..Approximately 10% of GERD patients develop Barrett's esophagus (BE), which is associated with nearly a 30-125-fold increased risk for the development of esophageal ..
- The role of KLF5 in GI epithelial homeostasis and diseaseJonathan Katz; Fiscal Year: 2009..vitro, is expressed in proliferating cells of gastrointestinal tract epithelia, including the basal cells of the esophagus. The interplay of these cells with the extracellular matrix (ECM) is critical to their function, and we have ..
- The role of KLF5 in GI epithelial homeostasis and diseaseJonathan Katz; Fiscal Year: 2009..vitro, is expressed in proliferating cells of gastrointestinal tract epithelia, including the basal cells of the esophagus. The interplay of these cells with the extracellular matrix (ECM) is critical to their function, and we have ..
- The temporal epigenomic program of Barrett's neoplastic progressionStephen J Meltzer; Fiscal Year: 2010Barrett's esophagus (BE), a sequela of chronic gastroesophageal reflux disease (GERD), is a premalignant condition that increases an individual's chance of developing esophageal adenocarcinoma (EAC) by 30-125- fold...
- The temporal epigenomic program of Barrett's neoplastic progressionStephen Meltzer; Fiscal Year: 2009Barrett's esophagus (BE), a sequela of chronic gastroesophageal reflux disease (GERD), is a premalignant condition that increases an individual's chance of developing esophageal adenocarcinoma (EAC) by 30-125- fold...
- Animal Model of Barrett's EsophagusXiaoxin Chen; Fiscal Year: 2003The aim of this project is to investigate the role of bile acids in the development of Barrett's esophagus (BE), and to develop an animal model for BE and esophageal adenocarcinoma (EAC)...
- BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENAPiero Biancani; Fiscal Year: 1993..and if untreated may result in chronic esophagitis, aspiration pneumonia, esophageal strictures, and Barretts esophagus, a premalignant condition...
- NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinomaWeibiao Cao; Fiscal Year: 2007..Approximately 10% of GERD patients develop Barrett's esophagus (BE) where esophageal squamous epithelium damaged by reflux esophagitis is replaced by a metaplastic, intestinal-..
- Improving Screening and Surveillance in Barrett's PatientsGuillermo J Tearney; Fiscal Year: 2010Barrett's esophagus (BE) is a metaplastic condition that is associated with chronic gastroesophageal reflux disease (GERD)...
- Combinational Chemoprevention of Esophageal Adenocarcin*Navtej Buttar; Fiscal Year: 2005Barrett's esophagus is a pre-malignant condition that predisposes to esophageal adenocarcinoma, which has one of the fastest rising incidence rates in the United States and has limited therapeutic options...
- A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUSKenneth Wang; Fiscal Year: 2003..cancers are the most rapidly increasing cancer in Caucasian males and are a consequence of Barrett's esophagus. Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)..
- INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITISPiero Biancani; Fiscal Year: 2010..the development of serious complications including ulcers, strictures, bleeding, columnar metaplasia (Barretts esophagus), and eventually adenocarcinoma of the esophagus...
- Role of H. Pylori Infection in Esophageal AdenocarcinomaKam Meng Tchou Wong; Fiscal Year: 2003..Colonization with cagA+ strains has been shown to be inversely associated with reflux esophagitis and Barrett's esophagus. A lower prevalence of cagA+ Helicobacter pylori has been observed in patient with gastroesophageal reflux ..
- INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITISPiero Biancani; Fiscal Year: 2009..the development of serious complications including ulcers, strictures, bleeding, columnar metaplasia (Barretts esophagus), and eventually adenocarcinoma of the esophagus...
- Biomarkers in Phototherapy of Barrett's EsophagusKenneth Wang; Fiscal Year: 2006The purpose of this study is to define the role of biomarkers in photodynamic therapy of Barrett's esophagus. Barrett's esophagus is felt to be the predisposing condition for the most rapidly increasing cancer in Caucasian males...
- Mechanistic Analysis of Eosinophilic EsophagitisAnil Mishra; Fiscal Year: 2009Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus that is being increasingly recognized especially during childhood. Notably, 70% of EE cases develop along with allergic asthma...
- Genetic Linkage Analysis of Barrett's EsophagusYvonne Romero; Fiscal Year: 2005..Barrett's esophagus, a premalignant lining of the esophagus, is the most robust risk factor for this highly lethal cancer...