esophagus

Summary

Summary: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.

Top Publications

  1. doi Incidence of adenocarcinoma among patients with Barrett's esophagus
    Frederik Hvid-Jensen
    Department of Surgical Gastroenterology L, Aarhus University Hospital, Aarhus, Denmark
    N Engl J Med 365:1375-83. 2011
  2. ncbi In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
  3. doi Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)
    Paul Swain
    Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
    Gastrointest Endosc 71:1290-3. 2010
  4. ncbi Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    Weiguo Shu
    Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:1991-2000. 2007
  5. doi Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  6. doi Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011
  7. doi A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
    Christopher J Peters
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    Gastroenterology 139:1995-2004.e15. 2010
  8. pmc Durability of radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Gastroenterology 141:460-8. 2011
  9. doi Esophageal acid exposure decreases intraluminal baseline impedance levels
    Boudewijn F Kessing
    Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, The Netherlands
    Am J Gastroenterol 106:2093-7. 2011
  10. pmc Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopy
    Michael B Wallace
    Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Gastrointest Endosc 72:19-24. 2010

Detail Information

Publications294 found, 100 shown here

  1. doi Incidence of adenocarcinoma among patients with Barrett's esophagus
    Frederik Hvid-Jensen
    Department of Surgical Gastroenterology L, Aarhus University Hospital, Aarhus, Denmark
    N Engl J Med 365:1375-83. 2011
    Accurate population-based data are needed on the incidence of esophageal adenocarcinoma and high-grade dysplasia among patients with Barrett's esophagus.
  2. ncbi In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
    ..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
  3. doi Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)
    Paul Swain
    Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
    Gastrointest Endosc 71:1290-3. 2010
    ..Remote manipulation of wireless capsule endoscopes might improve diagnostic accuracy and facilitate therapy...
  4. ncbi Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    Weiguo Shu
    Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:1991-2000. 2007
    ....
  5. doi Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  6. doi Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011
    ..Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man...
  7. doi A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
    Christopher J Peters
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    Gastroenterology 139:1995-2004.e15. 2010
    ..Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma...
  8. pmc Durability of radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Gastroenterology 141:460-8. 2011
    ..ablation (RFA) can eradicate dysplasia and intestinal metaplasia in patients with dysplastic Barrett's esophagus (BE), and reduce rates of esophageal adenocarcinoma...
  9. doi Esophageal acid exposure decreases intraluminal baseline impedance levels
    Boudewijn F Kessing
    Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, The Netherlands
    Am J Gastroenterol 106:2093-7. 2011
    ..The aim of this study was to investigate the baseline impedance in GERD patients, on and off proton pump inhibitor (PPI), and in healthy controls...
  10. pmc Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopy
    Michael B Wallace
    Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Gastrointest Endosc 72:19-24. 2010
    ..Confocal laser endomicroscopy (CLE) is a rapidly emerging method for in vivo imaging of the GI tract...
  11. doi Confocal laser scanning fluorescence microscopy for in vivo determination of microvessel density in Barrett's esophagus
    V Becker
    Department of Medicine II, Technical University of Munich, Munich, Germany
    Endoscopy 40:888-91. 2008
    Angiogenesis has been reported to be an essential step in the progression of cancers arising from Barrett's esophagus. Confocal laser scanning microscopy (CLM) has the potential to perform in vivo microscopy to detect angiogenesis and ..
  12. ncbi Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors
    G Bahrenberg
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, Aachen, D 52057, Germany
    Biochem Biophys Res Commun 275:783-8. 2000
    ..Furthermore, PSCA mRNA was highly abundant in normal esophagus and stomach, but was undetectable in esophageal or gastric tumors...
  13. ncbi Probe-based confocal laser endomicroscopy compared with standard four-quadrant biopsy for evaluation of neoplasia in Barrett's esophagus
    M Bajbouj
    II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Endoscopy 42:435-40. 2010
    Surveillance of Barrett's esophagus includes endoscopic inspection with biopsy of suspicious lesions followed by four-quadrant biopsy of the remaining mucosa...
  14. ncbi Endoscopic submucosal dissection of esophageal squamous cell neoplasms
    Mitsuhiro Fujishiro
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 4:688-94. 2006
    ..Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus.
  15. doi Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead?
    Robert H Riddell
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Gastroenterol 104:2588-94. 2009
    The definition of Barrett's esophagus (BE) varies worldwide, particularly with regard to the need to identify goblet cells in esophageal biopsies in order to diagnose this condition...
  16. ncbi Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
    Barrett's esophagus (BE) is a metaplastic condition in which normal squamous esophageal epithelium is replaced by columnar epithelium...
  17. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
  18. ncbi Etiology and pathogenesis of achalasia: the current understanding
    Woosuk Park
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 100:1404-14. 2005
    ..Current evidence suggests that the initial insult to the esophagus, perhaps a viral infection or some other environmental factor, results in myenteric plexus inflammation...
  19. doi Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus
    Dominique P Coco
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:45-54. 2011
    Recent morphologic and molecular evidence suggests that dysplasia in Barrett esophagus (BE) begins in the bases of the crypts [crypt dysplasia (CD)] and progresses with time to involve the upper portions of the crypts and surface ..
  20. pmc Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia
    David H Wang
    Graduate Training Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Gastroenterology 138:1810-22. 2010
    The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown...
  21. ncbi Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients
    Danny Yakoub
    Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, United Kingdom
    Cancer Res 70:9129-36. 2010
    ..This indicates that metabolic profiling of tissue can potentially play a role in the surveillance of cancer by reporting on the phenotypic consequences of field cancerization...
  22. pmc MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers
    Thomas X Lu
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Allergy Clin Immunol 129:1064-75.e9. 2012
    ..The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored...
  23. ncbi Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus
    Beau A Standish
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada
    Gastrointest Endosc 66:326-33. 2007
    ..DOCT) is an imaging modality that allows assessment of the microvascular response during photodynamic therapy (PDT) and may be a powerful tool for treatment monitoring/optimization in conditions such as Barrett's esophagus (BE).
  24. doi Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins
    Xin Chen
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G203-9. 2011
    ..In conclusion, acidic bile salts disrupted the squamous epithelial barrier function partly by modulating the amounts of claudin-1 and claudin-4. These results provide new insights for understanding the role of TJ proteins in esophagitis...
  25. doi Perception of dysphagia: lack of correlation with objective measurements of esophageal function
    A Lazarescu
    Centre for Gastroenterological Research, KU Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:1292-7, e336-7. 2010
    ....
  26. doi Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 92:22-31. 2012
    ..These localization patterns are similar to those in the human esophagus. On day 7 under ALI culture, TJ proteins were detected in the superficial layers with functional properties, ..
  27. ncbi Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 13:5305-13. 2007
    The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear...
  28. pmc History, molecular mechanisms, and endoscopic treatment of Barrett's esophagus
    Stuart Jon Spechler
    VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Gastroenterology 138:854-69. 2010
    ..Association Institute's medical position statement and technical review on the management of Barrett's esophagus, which will be published in the near future...
  29. ncbi Cdx2 as a marker of epithelial intestinal differentiation in the esophagus
    Roy W Phillips
    Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 27:1442-7. 2003
    The histologic diagnosis of Barrett's esophagus requires the presence of goblet cells, but this finding may not be the earliest indicator of intestinal metaplasia...
  30. pmc Induction of intestinalization in human esophageal keratinocytes is a multistep process
    Jianping Kong
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Carcinogenesis 30:122-30. 2009
    Barrett's esophagus (BE) is the replacement of normal squamous esophageal mucosa with an intestinalized columnar epithelium. The molecular mechanisms underlying its development are not understood...
  31. ncbi Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitis
    Georg Dimcevski
    Department of Medical Gastroenterology, Haukeland University Hospital, Bergen, Norway
    Pancreas 35:22-9. 2007
    ..We, therefore, aimed at exploring the pain mechanisms in chronic pancreatitis (CP) using a multimodal and multitissue stimulation approach...
  32. pmc Relevance of ineffective oesophageal motility during oesophageal acid clearance
    M Simren
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Gut 52:784-90. 2003
    ..Intraluminal impedance allows non-radiological monitoring of movement of oesophageal liquids...
  33. ncbi IL-5 promotes eosinophil trafficking to the esophagus
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 168:2464-9. 2002
    Eosinophil infiltration into the esophagus occurs in a wide range of diseases; however, the underlying pathophysiological mechanisms involved are largely unknown...
  34. pmc Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model
    T Ohki
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Gut 55:1704-10. 2006
    ..However, after aggressive ESD, a major complication that arises is postoperative inflammation and stenosis that can considerably affect the patient's quality of life...
  35. pmc Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
    ....
  36. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..Failure in septation between the trachea and the esophagus in Nkx2...
  37. pmc Bacterial biota in the human distal esophagus
    Zhiheng Pei
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:4250-5. 2004
    The esophagus, like other luminal organs of the digestive system, provides a potential environment for bacterial colonization, but little is known about the presence of a bacterial biota or its nature...
  38. ncbi Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Differentiation 74:422-37. 2006
    ..folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus. Defects in foregut morphogenesis underlie the constellation of human birth defects known as esophageal atresia (..
  39. ncbi High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry
    M Fox
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
    Neurogastroenterol Motil 16:533-42. 2004
    ..ii) The clinical value of HRM was assessed in a series of patients with endoscopy-negative dysphagia in whom conventional investigations had been non-diagnostic...
  40. pmc MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus
    Dipen M Maru
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Am J Pathol 174:1940-8. 2009
    Barrett's esophagus (BE)/Barrett's metaplasia (BM) is a recognized precursor of esophageal adenocarcinoma (EA) with an intermediary stage of dysplasia...
  41. ncbi Long-term clinical and pathologic response of Barrett's esophagus after antireflux surgery
    James M O'Riordan
    University Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Am J Surg 188:27-33. 2004
    The impact of antireflux surgery on outcome in Barrett's esophagus, in particular its effect on both the regression of metaplasia and the progression of metaplasia through dysplasia to adenocarcinoma, remains unclear...
  42. doi Radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, CB 7080, Chapel Hill, NC 27599 7080, USA
    N Engl J Med 360:2277-88. 2009
    Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma...
  43. ncbi Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    ..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
  44. pmc Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    Nan Gao
    Department of Genetics, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 16:588-99. 2009
    ..We conclude that Cdx2 controls important aspects of intestinal identity and development, and that this function is largely independent of the enteric Hox code...
  45. pmc Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:4174-84. 2010
    ....
  46. ncbi Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells
    Tong Liu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 28:488-96. 2007
    Caudal-related homeobox 2 (Cdx2) has been suggested as an early marker of Barrett's esophagus (BE), which is the premalignant lesion of esophageal adenocarcinoma (EAC)...
  47. ncbi Life isn't flat: taking cancer biology to the next dimension
    Keiran S M Smalley
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    In Vitro Cell Dev Biol Anim 42:242-7. 2006
    ..It is likely that the adoption of these and other 3D models will allow us to more closely re-create the behavior of the tumor in vivo which may lead to identifying better anticancer drug candidates at an earlier stage of development...
  48. ncbi Multiple fields may offer better esophagus sparing without increased probability of lung toxicity in optimized IMRT of lung tumors
    Olivier Chapet
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 65:255-65. 2006
    ..To evaluate whether increasing numbers of intensity-modulated radiation therapy (IMRT) fields enhance lung-tumor dose without additional predicted toxicity for difficult planning geometries...
  49. pmc A unique esophageal motor pattern that involves longitudinal muscles is responsible for emptying in achalasia esophagus
    Su Jin Hong
    Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, South Korea
    Gastroenterology 139:102-11. 2010
    Achalasia esophagus is characterized by loss of peristalsis and incomplete esophagogastric junction (EGJ) relaxation...
  50. ncbi Trends in Barrett's esophagus diagnosis in Southern Europe: implications for surveillance
    Javier Alcedo
    Service of Digestive Diseases, Clínico Lozano Blesa Hospital, Institute of Health Sciences, CIBERehd, University of Zaragoza, Zaragoza, Spain
    Dis Esophagus 22:239-48. 2009
    The incidence of Barrett's esophagus (BE) and esophageal adenocarcinoma has increased in Western countries in recent decades...
  51. doi The role of radiofrequency ablation in the management of Barrett's esophagus
    William J Bulsiewicz
    GI Outcomes Training Program, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Gastrointest Endosc Clin N Am 21:95-109. 2011
    ..RFA) to be effective, safe, and well tolerated in the treatment of nondysplastic and dysplastic Barrett's esophagus (BE). The results found at academic medical centers have been reproduced in the community setting...
  52. doi Bile in the esophagus-model for a bile acid biosensor
    Dhiren Nehra
    Department of Upper GI Surgery, Epsom and St Helier University Hospital, Carshalton, Surrey, SM7 1LA, UK
    J Gastrointest Surg 14:S6-8. 2010
    ..This paper looks at a model for development of a biosensor for bile acid based on molecular imprinted polymers...
  53. ncbi Assessment of intraluminal impedance for the detection of pharyngeal bolus flow during swallowing in healthy adults
    Taher I Omari
    Department of Paediatrics, University of Adelaide, and Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Adelaide, South Australia
    Am J Physiol Gastrointest Liver Physiol 290:G183-8. 2006
    ..In contrast, in the upper esophageal sphincter (UES) and proximal esophagus, the timing of impedance recovery correlated well with the timing of clearance of the bolus tail...
  54. doi Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagus
    Ricard Farre
    Center for Gastroenterological Research, Catholic University Leuven, Belgium
    Gut 59:164-9. 2010
    ..We aimed to assess the effect of oesophageal perfusions with acid and weakly acidic solutions on 'exposed' and 'non-exposed' oesophageal mucosa and its relationship to symptoms in healthy subjects...
  55. ncbi Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010
    ..Here we directly compared gene expression profiles in human esophageal squamous cell carcinomas and in human fetal esophagus development...
  56. doi Criteria for assessing esophageal motility in laparoscopic adjustable gastric band patients: the importance of the lower esophageal contractile segment
    Paul Robert Burton
    Centre for Obesity Research and Education CORE, Monash Medical School, The Alfred Hospital, Commercial RD Prahran, 3181, Melbourne, Australia
    Obes Surg 20:316-25. 2010
    ..Recent combined video fluoroscopic and high-resolution manometric studies have identified important components of esophageal function in LAGB patients...
  57. ncbi Brain stem control of swallowing: neuronal network and cellular mechanisms
    A Jean
    Laboratoire de Neurobiologie des Fonctions Vegetatives, Departement de Physiologie et Neurophysiologie, Faculté des Sciences et Techniques Saint Jérôme, Marseille, France
    Physiol Rev 81:929-69. 2001
    ..The mechanisms possibly involved in pattern generation and the possible flexibility of the swallowing central pattern generator are discussed...
  58. pmc Detection of dysplasia in Barrett's esophagus with in vivo depth-resolved nuclear morphology measurements
    Neil G Terry
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Gastroenterology 140:42-50. 2011
    Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes...
  59. doi Reproducibility of esophageal high-resolution manometry
    A Bogte
    Gastrointestinal Research Unit, Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 23:e271-6. 2011
    ..Until now, the reproducibility of these parameters has not been investigated...
  60. pmc Manometric features of eosinophilic esophagitis in esophageal pressure topography
    S Roman
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    Neurogastroenterol Motil 23:208-14, e111. 2011
    ..The aims of this study were to evaluate the esophageal pressure topography (EPT) findings in EoE and to compare them with controls and patients with gastro-esophageal disease (GERD)...
  61. ncbi Post-corrosive late complications in esophagus and stomach--role of the esophageal rest
    Andon Chibisev
    University Clinic for Toxicology, Clinical Centre, Skopje, Republic of Macedonia
    Med Arh 64:320-3. 2010
    ..cause severe chemical injuries of the upper gastrointestinal tract, the most common location being the esophagus and the stomach...
  62. pmc Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity
    Negin Behazin
    Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:212-8. 2010
    ..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes...
  63. doi Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?
    Gerrit J M Hemmink
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 103:2446-53. 2008
    ..Until now, it is unclear whether combined pH-impedance monitoring in these patients should be performed on or off PPI...
  64. doi A prospective study to compare a symptom-based reflux disease questionnaire to 48-h wireless pH monitoring for the identification of gastroesophageal reflux (revised 2-26-11)
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Am J Gastroenterol 106:1604-11. 2011
    ..The aim of this study was to prospectively evaluate the association between GerdQ scores and 48-h wireless pH recording in patients studied either on or off acid suppression...
  65. doi Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal reflux
    Clara M Loots
    Academic Medical Centre, Amsterdam, The Netherlands
    J Pediatr 154:248-52. 2009
    ..To assess the additional yield of combined multichannel intraluminal pH-impedance (pH-MII) monitoring compared with standard pH monitoring on gastroesophageal reflux (GER) symptom associations in infants and children...
  66. doi The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection
    Satoru Hashimoto
    Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan
    Gastrointest Endosc 74:1389-93. 2011
    ....
  67. ncbi Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition
    Minli Wang
    USRA, Division of Life Sciences, Houston, TX 77058, USA
    J Radiat Res 53:51-7. 2012
    ....
  68. ncbi Foreign body ingestion in children
    Monte C Uyemura
    Wray Rural Training Tract Family Medicine Residency Program, Wray, Colorado, USA
    Am Fam Physician 72:287-91. 2005
    ..Foreign bodies lodged in the esophagus should be removed endoscopically, but some small, blunt objects may be pulled out using a Foley catheter or ..
  69. pmc Reflux events detected by pH-MII do not determine fundoplication outcome
    Rachel Rosen
    Center for Motility and Functional Gastrointestinal Disorders, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Pediatr Gastroenterol Nutr 50:251-5. 2010
    ..The aim of the study was to determine predictors of fundoplication outcome including acid and nonacid reflux burden...
  70. pmc Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment
    Amir F Kagalwalla
    Department of Pediatrics, Children s Memorial Hospital and Northwestern University, Chicago, IL, USA
    J Allergy Clin Immunol 129:1387-1396.e7. 2012
    ..Mechanisms underlying esophageal remodeling with subepithelial fibrosis in subjects with eosinophilic esophagitis (EoE) have not been delineated...
  71. ncbi Loss of manganese superoxide dismutase expression and activity in rat esophagus with external esophageal perfusion
    Yan Li
    Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Surgery 141:359-67. 2007
    ..Thus, the aim of this study is to investigate the role of MnSOD expression and activity in rats with esophageal perfusion injury...
  72. pmc Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus
    Le Qiu
    Biomedical Imaging and Spectroscopy Laboratory, Department of Obstetrics, Harvard University and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 16:603-6, 1p following 606. 2010
    Esophageal cancer is increasing in frequency in the United States faster than any other cancer. Barrett's esophagus, an otherwise benign complication of esophageal reflux, affects approximately three million Americans and precedes almost ..
  73. doi Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy
    Clara M Loots
    Department of Pediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 53:120-3. 2011
    ..28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease...
  74. pmc Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus
    Hejin P Hahn
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1006-15. 2009
    Barrett esophagus (BE) is defined by the presence of metaplastic esophageal columnar epithelium with goblet cells within endoscopically recognizable areas of the esophagus...
  75. doi Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
    ..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
  76. ncbi Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus
    Ryu Ishihara
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
    J Gastroenterol Hepatol 25:1410-5. 2010
    ..The primary endpoint of the present study was to identify the significant NBI findings to diagnose esophageal mucosal high-grade neoplasia...
  77. ncbi Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia
    Peter Ngo
    Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 101:1666-70. 2006
    Scattered eosinophils in the distal esophagus traditionally provide the hallmark for peptic esophagitis, but the upper limit of eosinophils and the longitudinal extent of peptic inflammation along the esophagus are unknown...
  78. ncbi Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia
    Jantine W P M van Baal
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Cancer Res 66:11605-12. 2006
    The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that occur in Barrett's esophagus are poorly understood, this study aimed at ..
  79. ncbi Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma
    Ken ichi Goda
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Gastrointest Endosc 65:36-46. 2007
    Barrett's esophagus with specialized intestinal metaplasia (SIM) from columnar-lined esophagus is difficult to distinguish with routine endoscopy.
  80. ncbi CT features of esophageal emergencies
    Catherine A Young
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Radiographics 28:1541-53. 2008
    ..An awareness of the CT findings associated with the spectrum of acute esophageal disease facilitates the accurate and prompt diagnosis of esophageal emergencies and thereby contributes to a more successful outcome...
  81. ncbi The prognostic impact of O6-Methylguanine-DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma
    S Baumann
    Institute for Pathology and Pathologic Anatomy, Technical University of Munich, Munich, Germany
    Int J Cancer 119:264-8. 2006
    ..In conclusion, MGMT hypermethylation in esophageal adenocarcinoma is a frequent event that is associated with loss of MGMT protein expression but not with patient's outcome...
  82. ncbi Non-biopsy detection of intestinal metaplasia and dysplasia in Barrett's esophagus: a prospective multicenter study
    P Sharma
    University of Kansas School of Medicine and Veterans Affairs Medical Center, Kansas City, MO, USA
    Endoscopy 38:1206-12. 2006
    ..magnification chromoendoscopy (MCE) for the detection of intestinal metaplasia and dysplasia/cancer in Barrett's esophagus. Our aims were to assess the ability of MCE to predict the histological diagnosis (non-biopsy detection), to ..
  83. ncbi A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia
    Jantine W P M van Baal
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 129:1274-81. 2005
    The metaplastic process in which the normal squamous epithelium of the distal esophagus is replaced by columnar-lined epithelium, known as Barrett's esophagus (BE), is poorly understood...
  84. ncbi Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus
    Wei Yuan Yu
    Department of Biology and Biochemistry, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Dev Biol 284:157-70. 2005
    ..The results show that, in normal development, the squamous epithelium arises from the columnar epithelium by a direct conversion process...
  85. pmc Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas
    Charles A Fox
    Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 7:407-16. 2005
    Identification of biomarkers to recognize individuals with Barrett's esophagus (BE) predisposed to develop malignancy is currently a pressing issue...
  86. pmc Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus
    Vladimir Ustiyan
    Divisions of Pulmonary Biology, Perinatal Institute of the Cincinnati Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Dev Biol 336:266-79. 2009
    ..mice died immediately after birth due to severe pulmonary hemorrhage and structural defects in arterial wall and esophagus. Although Foxm1 deletion did not influence SMC differentiation, decreased proliferation of SMC was found in ..
  87. pmc NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 139:2113-23. 2010
    ..However, the functional roles of Notch in esophageal squamous epithelial biology are unknown...
  88. doi Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial
    D E Fleischer
    Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Endoscopy 42:781-9. 2010
    The AIM-II Trial included patients with nondysplastic Barrett's esophagus (NDBE) treated with radiofrequency ablation (RFA). Complete eradication of NDBE (complete response-intestinal metaplasia [CR-IM]) was achieved in 98...
  89. doi Intensity-modulated radiotherapy for locally advanced non-small-cell lung cancer: a dose-escalation planning study
    Yolande Lievens
    Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 80:306-13. 2011
    ..To evaluate the potential for dose escalation with intensity-modulated radiotherapy (IMRT) in positron emission tomography-based radiotherapy planning for locally advanced non-small-cell lung cancer (LA-NSCLC)...
  90. ncbi Clinical practice. Barrett's Esophagus
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas 75216, USA
    N Engl J Med 346:836-42. 2002
  91. pmc Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis
    Aaron Goldman
    Department of Cell Biology and Anatomy, Univ of Arizona, 1501 N Campbell Ave P O Box 245044, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 300:G292-302. 2011
    Barrett's esophagus (BE) is a premalignant condition, where normal squamous epithelium is replaced by intestinal epithelium. BE is associated with an increased risk of developing esophageal adenocarcinoma (EAC)...
  92. ncbi P53 and Ki-67 overexpression in gastroesophageal reflux disease--Barrett's esophagus and adenocarcinoma sequence
    M Binato
    Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil
    Dis Esophagus 22:588-95. 2009
    ..001 and P < 0.05). Our results indicate that overexpression of p53 and increased Ki-67 could be associated with the development and progression to ACE in patients with GERD...
  93. pmc Safety and efficacy of endoscopic spray cryotherapy for Barrett's esophagus with high-grade dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Gastrointest Endosc 71:680-5. 2010
    Endoscopic ablation to treat Barrett's esophagus (BE) with high-grade dysplasia (HGD) is associated with a decreased incidence of esophageal adenocarcinoma. Endoscopic spray cryotherapy (CRYO) demonstrates promising preliminary data.
  94. doi Regulation of CDX2 expression in esophageal adenocarcinoma
    Nadine Vaninetti
    Department of Pathology, Dalhousie University, Halifax, NS, Canada
    Mol Carcinog 48:965-74. 2009
    Reflux of acidic gastric contents and bile acids into the lower esophagus has been identified to have a central role in esophageal malignancy and is reported to upregulate caudal-related homologue 2 (CDX2), a regulatory gene involved in ..
  95. doi Intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil) after laparoscopic total gastrectomy
    Oh Jeong
    Department of Gastroenterologic Surgery, Chonnam National University Hwasun Hospital, 160, Ilsim Ri, Hwasun eup, Hwasun Gun, Jeollanam do, 519 809, Korea
    Surg Endosc 23:2624-30. 2009
    ..The authors report the newly developed reconstruction technique after LTG: intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil; Covidien, Mansfield, MA, USA)...
  96. ncbi Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa
    Akashi Eda
    Department of Internal Medicine, Jichi Medical School, Yakushiji, Kawachi, Tochigi 329 0438, Japan
    J Gastroenterol 38:14-22. 2003
    ..The present study was designed to examine the expression of CDX 1/2 in inflammatory esophageal mucosa with or without Barrett's epithelium...
  97. pmc Analysis of component findings in 79 patients diagnosed with VACTERL association
    Benjamin D Solomon
    Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Am J Med Genet A 152:2236-44. 2010
    ..These findings have implications for both our understanding of VACTERL association and for the approach to research involving this condition...
  98. ncbi Neurocognitive processing of esophageal central sensitization in the insula and cingulate gyrus
    Adeyemi Lawal
    Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Gastrointest Liver Physiol 294:G787-94. 2008
    ..the neurocognitive processing in the cingulate and insular cortices to mechanical stimulation of the proximal esophagus following infusion of acid or phosphate buffer solution (PBS) into the esophagus...
  99. doi Deterioration of muscle function in the human esophagus with age
    Hans Gregersen
    Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital, Aalborg, Denmark
    Dig Dis Sci 53:3065-70. 2008
    ..Esophageal motor function is traditionally studied by means of manometry and radiography. Distension of the esophagus with evaluation of active and passive mechanical parameters have become available during recent years...
  100. doi Prevalence and risk factors of Barrett's esophagus in patients undergoing endoscopy for upper gastrointestinal symptoms
    Li Shou Xiong
    Department of Gastroenterology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    J Dig Dis 11:83-7. 2010
    To investigate the prevalence of Barrett's esophagus (BE) and its risk factors in patients undergoing endoscopy for upper gastrointestinal symptoms in a Chinese tertiary referral medical center.
  101. ncbi Prevalence of Barrett's esophagus in the general population: an endoscopic study
    Jukka Ronkainen
    Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 129:1825-31. 2005
    Barrett's esophagus (BE) is associated with esophageal adenocarcinoma, the incidence of which has been increasing dramatically. The prevalence of BE in the general population is uncertain because upper endoscopy is required for diagnosis...

Research Grants89

  1. The effects of glucose on central vagal brainstem circuits
    KIRSTEEN NAIRN BROWNING; Fiscal Year: 2010
    ..The receptive relaxation reflex is a classical, vagally-mediated reflex activated upon distension of the esophagus (during swallowing, for example) that induces gastric relaxation and suppression of motility, allowing the ..
  2. Stretch Sensitive Neurons and Lower Esophageal Sphincter
    RAVINDER MITTAL; Fiscal Year: 2009
    ..Neurons &Lower Esophageal Sphincter Relaxation The lower esophageal sphincter guards the entrance from the esophagus to the stomach, its incompetence (too much relaxation) leads to gastro-esophageal reflux (GER) and heartburn" ..
  3. Basic and Clinical Studies on the Role of Bile Acids in Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE), which are exceptionally common disorders in adult Americans, are strong risk factors for esophageal adenocarcinoma...
  4. EXPERIMENTAL TOBACCO CARCINOGENESIS
    DIETRICH HOFFMAN; Fiscal Year: 1992
    Cigarette smoking is causally associated with cancer of the lung, larynx and esophagus and increases the risk for cancer of the pancreas, kidney and urinary bladder and, likely, the cervix...
  5. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2001
    ..and contraction of the CD in relationship to the LES, the compressive effect and forces of the CD on the distal esophagus, the role of the CD in antegrade movement of liquids and the role of the CD in induced relaxation of the GEJHPZ ..
  6. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2003
    ..and contraction of the CD in relationship to the LES, the compressive effect and forces of the CD on the distal esophagus, the role of the CD in antegrade movement of liquids and the role of the CD in induced relaxation of the GEJHPZ ..
  7. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2006
    ..and contraction of the CD in relationship to the LES, the compressive effect and forces of the CD on the distal esophagus, the role of the CD in antegrade movement of liquids and the role of the CD in induced relaxation of the GEJHPZ ..
  8. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2002
    ..and contraction of the CD in relationship to the LES, the compressive effect and forces of the CD on the distal esophagus, the role of the CD in antegrade movement of liquids and the role of the CD in induced relaxation of the GEJHPZ ..
  9. Clinical Studies on Bile Acids in Barrett's Esophagus
    Stuart Spechler; Fiscal Year: 2009
    ..provided by applicant): Project Summary/Abstract Gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE), which are exceptionally common disorders in Veteran patients, are strong risk factors for esophageal ..
  10. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2009
    ..take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
  11. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2010
    ..take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
  12. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2009
    ..is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE). Our preliminary study in elderly male veterans found two types of microbiotas in the esophagus...
  13. Foregut microbiome in development of esophageal adenocarcinoma
    ZHIHENG contact PEI; Fiscal Year: 2010
    ..is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE). Our preliminary study in elderly male veterans found two types of microbiotas in the esophagus...
  14. Modeling Neoplastic Progression in Barrett's Esophagus
    Carlo C Maley; Fiscal Year: 2011
    ..We propose to develop an agent-based computational model of neoplastic progression in Barrett's esophagus as a tool to study the dynamics of neoplastic progression and to integrate the genetic, pathological, clinical, ..
  15. Modeling Neoplastic Progression in Barrett's Esophagus
    Carlo Maley; Fiscal Year: 2009
    ..We propose to develop an agent-based computational model of neoplastic progression in Barrett's esophagus as a tool to study the dynamics of neoplastic progression and to integrate the genetic, pathological, clinical, ..
  16. Modeling Neoplastic Progression in Barrett's Esophagus
    John W Pepper; Fiscal Year: 2010
    ..We propose to develop an agent-based computational model of neoplastic progression in Barrett's esophagus as a tool to study the dynamics of neoplastic progression and to integrate the genetic, pathological, clinical, ..
  17. EPIDEMIOLOGIC STUDY OF ESOPHAGEAL/GASTRIC ADENOCARCINOMA
    Harvey Risch; Fiscal Year: 1992
    ..S. cancer incidence data for the period 1976-87 have revealed sharply rising rates for adenocarcinoma of the esophagus and gastric cardia...
  18. Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective Study
    Prateek Sharma; Fiscal Year: 2009
    ..Our hypothesis is that NBI identifies changes in the distal esophagus that are specific for diagnosing patients with NERD...
  19. Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
    ANSON LOWE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Barrett's esophagus is a premalignant lesion that increases the risk for esophageal adenocarcinoma...
  20. Determinants of AGR2 effects in Barrett's esophagus and esophageal adenocarcinoma
    Anson W Lowe; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Barrett's esophagus is a premalignant lesion that increases the risk for esophageal adenocarcinoma...
  21. Clinical Risk Factors for Barretts Esophagus in a Primary Care Setting
    Blair Jobe; Fiscal Year: 2009
    ..Most patients who develop esophageal adenocarcinoma (EAC) are unaware of the presence of Barrett's esophagus (BE) prior to cancer diagnosis, and 57% have never reported chronic symptoms of gastroesophageal reflux disease (..
  22. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    ..improvement in survival of patients with cancers detected by routine endoscopic surveillance for Barrett's esophagus. In spite of these efforts, the majority of patients who develop esophageal adenocarcinoma are unaware of the ..
  23. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2003
    ..improvement in survival of patients with cancers detected by routine endoscopic surveillance for Barrett's esophagus. In spite of these efforts, the majority of patients who develop esophageal adenocarcinoma are unaware of the ..
  24. CHEMOSENSITIVE NEURONS AND ESOPHAGEAL BLOOD FLOW
    Barbara Bass; Fiscal Year: 1991
    ..esophagitis can cause severe pain, bleeding, ulceration and stricture and in rare instances, carcinoma of the esophagus. The pathogenesis of this condition remains under investigation...
  25. Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus Patients
    HODA J BADR; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Highly prevalent in the U.S., Barrett's Esophagus (BE) results from chronic gastroesophageal reflux disease (GERD) and is a major risk factor for the development of esophageal adenocarcinoma (..
  26. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2009
    ..It is also the most difficult scenario because the contracted esophagus holds the object with substantial force...
  27. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2010
    ..It is also the most difficult scenario because the contracted esophagus holds the object with substantial force...
  28. Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus Patients
    Hoda Badr; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Highly prevalent in the U.S., Barrett's Esophagus (BE) results from chronic gastroesophageal reflux disease (GERD) and is a major risk factor for the development of esophageal adenocarcinoma (..
  29. Photoacoustic endoscopy of Barretts esophagus
    QIFA NO ZHOU; Fiscal Year: 2010
    ..Parts of the gastrointestinal tract, including the esophagus, large intestine, and rectum, and/or parts of the cardiovascular system of animals, will be imaged in vivo or ex ..
  30. Influence of acid reflux on stromal epithelial interaction in Barrett?s esophagus
    GANAPATHY PRASAD; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE) is an important risk factor for esophageal adenocarcinoma. Duodenogastric reflux leads to chronic inflammation and the development of BE in a subset of patients1, 2...
  31. Micro RNA expression in esophageal adenocarcinoma
    Virginia Litle; Fiscal Year: 2007
    ..Chronic reflux exposes the distal esophagus to stomach acid and bile causing irritation and inflammation...
  32. Transnasal Esophagoscopy vs. Esophageal Capsule Endoscopy for Barrett's Screening
    Amitabh Chak; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Metaplastic transformation of the esophagus, termed Barrett's esophagus (BE) is a premalignant condition with a 1 per 200 patient-years risk of malignant progression to esophageal adenocarcinoma...
  33. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2007
    ..The gastric inflammatory response to H. pylori may decrease acid production and reflux in the esophagus. Differences in the host mucosal inflammatory response to H...
  34. ETIOLOGY OF GASTRIC CARDIA/ESOPHAGEAL ADENOCARCINOMA
    Leslie Bernstein; Fiscal Year: 1993
    ..S. during the past 50 years but the incidence of adenocarcinoma of the gastric cardia and lower esophagus has recently substantially increased...
  35. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2009
    ..Approximately 10% of GERD patients develop Barrett's esophagus (BE), which is associated with nearly a 30-125-fold increased risk for the development of esophageal ..
  36. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2010
    ..Approximately 10% of GERD patients develop Barrett's esophagus (BE), which is associated with nearly a 30-125-fold increased risk for the development of esophageal ..
  37. The role of KLF5 in GI epithelial homeostasis and disease
    Jonathan Katz; Fiscal Year: 2009
    ..vitro, is expressed in proliferating cells of gastrointestinal tract epithelia, including the basal cells of the esophagus. The interplay of these cells with the extracellular matrix (ECM) is critical to their function, and we have ..
  38. The role of KLF5 in GI epithelial homeostasis and disease
    Jonathan Katz; Fiscal Year: 2009
    ..vitro, is expressed in proliferating cells of gastrointestinal tract epithelia, including the basal cells of the esophagus. The interplay of these cells with the extracellular matrix (ECM) is critical to their function, and we have ..
  39. The temporal epigenomic program of Barrett's neoplastic progression
    Stephen J Meltzer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE), a sequela of chronic gastroesophageal reflux disease (GERD), is a premalignant condition that increases an individual's chance of developing esophageal ..
  40. The temporal epigenomic program of Barrett's neoplastic progression
    Stephen Meltzer; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE), a sequela of chronic gastroesophageal reflux disease (GERD), is a premalignant condition that increases an individual's chance of developing esophageal ..
  41. RADIATION THERAPY ONCOLOGY GROUP
    Walter Curran; Fiscal Year: 1992
    ..Phase III trials have been, or will soon be completed with inoperable carcinoma of the esophagus, lung, and bladder...
  42. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2003
    The purpose of this study is to define the role of biomarkers in photodynamic therapy of Barrett's esophagus. Barrett's esophagus is felt to be the predisposing condition for the most rapidly increasing cancer in Caucasian males...
  43. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2002
    The purpose of this study is to define the role of biomarkers in photodynamic therapy of Barrett's esophagus. Barrett's esophagus is felt to be the predisposing condition for the most rapidly increasing cancer in Caucasian males...
  44. Animal Model of Barrett's Esophagus
    Xiaoxin Chen; Fiscal Year: 2002
    The aim of this project is to investigate the role of bile acids in the development of Barrett's esophagus (BE), and to develop an animal model for BE and esophageal adenocarcinoma (EAC)...
  45. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 1992
    ..and if untreated may result in chronic esophagitis, aspiration pneumonia, esophageal strictures, and Barretts esophagus, a premalignant condition...
  46. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 1990
    ..and if untreated may result in chronic esophagitis, aspiration pneumonia, esophageal strictures, and Barretts esophagus, a premalignant condition...
  47. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 1991
    ..and if untreated may result in chronic esophagitis, aspiration pneumonia, esophageal strictures, and Barretts esophagus, a premalignant condition...
  48. Animal Model of Barrett's Esophagus
    Xiaoxin Chen; Fiscal Year: 2003
    The aim of this project is to investigate the role of bile acids in the development of Barrett's esophagus (BE), and to develop an animal model for BE and esophageal adenocarcinoma (EAC)...
  49. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 1993
    ..and if untreated may result in chronic esophagitis, aspiration pneumonia, esophageal strictures, and Barretts esophagus, a premalignant condition...
  50. ADENOCARCINOMAS OF THE ESOPHAGUS AND GASTRIC CARDIA
    Marilie Gammon; Fiscal Year: 1992
    Within the last two decades, reported incidence rates of adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly in many Westernized countries including the United States...
  51. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2007
    ..Approximately 10% of GERD patients develop Barrett's esophagus (BE) where esophageal squamous epithelium damaged by reflux esophagitis is replaced by a metaplastic, intestinal-..
  52. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2006
    ..Approximately 10% of GERD patients develop Barrett's esophagus (BE) where esophageal squamous epithelium damaged by reflux esophagitis is replaced by a metaplastic, intestinal-..
  53. Improving Screening and Surveillance in Barrett's Patients
    Guillermo J Tearney; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE) is a metaplastic condition that is associated with chronic gastroesophageal reflux disease (GERD)...
  54. REGULATION OF INTESTIANL CELL IDENTITY
    Deborah Gumucio; Fiscal Year: 2002
    ..between these two layers over the course of development result in the regional patterning of the gut into esophagus, stomach, small intestine and large intestine; each region adopts a distinct epithelial morphology and gene ..
  55. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2004
    Barrett's esophagus is a pre-malignant condition that predisposes to esophageal adenocarcinoma, which has one of the fastest rising incidence rates in the United States and has limited therapeutic options...
  56. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2005
    Barrett's esophagus is a pre-malignant condition that predisposes to esophageal adenocarcinoma, which has one of the fastest rising incidence rates in the United States and has limited therapeutic options...
  57. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2000
    ..cancers are the most rapidly increasing cancer in Caucasian males and are a consequence of Barrett's esophagus. Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)..
  58. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2002
    ..cancers are the most rapidly increasing cancer in Caucasian males and are a consequence of Barrett's esophagus. Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)..
  59. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2001
    ..cancers are the most rapidly increasing cancer in Caucasian males and are a consequence of Barrett's esophagus. Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)..
  60. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..cancers are the most rapidly increasing cancer in Caucasian males and are a consequence of Barrett's esophagus. Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)..
  61. INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITIS
    Piero Biancani; Fiscal Year: 2010
    ..the development of serious complications including ulcers, strictures, bleeding, columnar metaplasia (Barretts esophagus), and eventually adenocarcinoma of the esophagus...
  62. Role of H. Pylori Infection in Esophageal Adenocarcinoma
    Kam Meng Tchou Wong; Fiscal Year: 2002
    ..Colonization with cagA+ strains has been shown to be inversely associated with reflux esophagitis and Barrett's esophagus. A lower prevalence of cagA+ Helicobacter pylori has been observed in patient with gastroesophageal reflux ..
  63. Role of H. Pylori Infection in Esophageal Adenocarcinoma
    Kam Meng Tchou Wong; Fiscal Year: 2003
    ..Colonization with cagA+ strains has been shown to be inversely associated with reflux esophagitis and Barrett's esophagus. A lower prevalence of cagA+ Helicobacter pylori has been observed in patient with gastroesophageal reflux ..
  64. INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITIS
    Piero Biancani; Fiscal Year: 2009
    ..the development of serious complications including ulcers, strictures, bleeding, columnar metaplasia (Barretts esophagus), and eventually adenocarcinoma of the esophagus...
  65. INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITIS
    Piero Biancani; Fiscal Year: 2009
    ..the development of serious complications including ulcers, strictures, bleeding, columnar metaplasia (Barretts esophagus), and eventually adenocarcinoma of the esophagus...
  66. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2005
    ..The gastric inflammatory response to H. pylori may decrease acid production and reflux in the esophagus. Differences in the host mucosal inflammatory response to H...
  67. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2004
    ..The gastric inflammatory response to H. pylori may decrease acid production and reflux in the esophagus. Differences in the host mucosal inflammatory response to H...
  68. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2006
    ..The gastric inflammatory response to H. pylori may decrease acid production and reflux in the esophagus. Differences in the host mucosal inflammatory response to H...
  69. INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITIS
    Piero Biancani; Fiscal Year: 2007
    ..the development of serious complications including ulcers, strictures, bleeding, columnar metaplasia (Barretts esophagus), and eventually adenocarcinoma of the esophagus...
  70. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2006
    ..The purpose of this study is to define the role of biomarkers in photodynamic therapy of Barrett's esophagus. Barrett's esophagus is felt to be the predisposing condition for the most rapidly increasing cancer in ..
  71. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2004
    The purpose of this study is to define the role of biomarkers in photodynamic therapy of Barrett's esophagus. Barrett's esophagus is felt to be the predisposing condition for the most rapidly increasing cancer in Caucasian males...
  72. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2005
    The purpose of this study is to define the role of biomarkers in photodynamic therapy of Barrett's esophagus. Barrett's esophagus is felt to be the predisposing condition for the most rapidly increasing cancer in Caucasian males...
  73. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    DIANA FARROW; Fiscal Year: 1999
    DESCRIPTION: Barrett's esophagus is a metaplastic condition that develops in an estimated 10-20% of persons with long-standing gastroesophageal reflux disease (GERD)...
  74. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    Thomas Vaughan; Fiscal Year: 2000
    DESCRIPTION: Barrett's esophagus is a metaplastic condition that develops in an estimated 10-20% of persons with long-standing gastroesophageal reflux disease (GERD)...
  75. Low-cost tethered capsule endoscope for screening for Barrett's esophagus
    Jason Dominitz; Fiscal Year: 2009
    ..EGD) is recommended by the American College of Gastroenterology to screen for Barrett's esophagus (BE) in patients with longstanding symptoms of gastroesophageal reflux disease, as BE is a documented risk ..
  76. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus that is being increasingly recognized especially during childhood. Notably, 70% of EE cases develop along with allergic asthma...
  77. Genetic Linkage Analysis of Barrett's Esophagus
    Yvonne Romero; Fiscal Year: 2005
    ..Barrett's esophagus, a premalignant lining of the esophagus, is the most robust risk factor for this highly lethal cancer...
  78. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2006
    Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus that is being increasingly recognized especially during childhood. Notably, 70% of EE cases develop along with allergic asthma...
  79. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2007
    Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus that is being increasingly recognized especially during childhood. Notably, 70% of EE cases develop along with allergic asthma...
  80. Modulation of DNA methylation status by dietary zinc: role in cancer prevention
    LOUISE FONG; Fiscal Year: 2009
    ..Our new data showed overexpression of DNA methyltransferase enzymes DNMT3A and DNMT1 in ZD versus ZS rat esophagus and their repression upon ZR...
  81. Genetic Linkage Analysis of Barrett's Esophagus
    Yvonne Romero; Fiscal Year: 2004
    ..Barrett's esophagus, a premalignant lining of the esophagus, is the most robust risk factor for this highly lethal cancer...
  82. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2005
    Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus that is being increasingly recognized especially during childhood. Notably, 70% of EE cases develop along with allergic asthma...