esophagus

Summary

Summary: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.

Top Publications

  1. ncbi Incidence of adenocarcinoma among patients with Barrett's esophagus
    Frederik Hvid-Jensen
    Department of Surgical Gastroenterology L, Aarhus University Hospital, Aarhus, Denmark
    N Engl J Med 365:1375-83. 2011
  2. ncbi In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
  3. ncbi Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)
    Paul Swain
    Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
    Gastrointest Endosc 71:1290-3. 2010
  4. doi Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  5. pmc Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus
    Massimiliano Di Pietro
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, CB2 0XZ Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 109:9077-82. 2012
  6. ncbi A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
    Christopher J Peters
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    Gastroenterology 139:1995-2004.e15. 2010
  7. pmc Durability of radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Gastroenterology 141:460-8. 2011
  8. pmc Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopy
    Michael B Wallace
    Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Gastrointest Endosc 72:19-24. 2010
  9. ncbi Esophageal acid exposure decreases intraluminal baseline impedance levels
    Boudewijn F Kessing
    Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, The Netherlands
    Am J Gastroenterol 106:2093-7. 2011
  10. ncbi Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011

Detail Information

Publications336 found, 100 shown here

  1. ncbi Incidence of adenocarcinoma among patients with Barrett's esophagus
    Frederik Hvid-Jensen
    Department of Surgical Gastroenterology L, Aarhus University Hospital, Aarhus, Denmark
    N Engl J Med 365:1375-83. 2011
    Accurate population-based data are needed on the incidence of esophageal adenocarcinoma and high-grade dysplasia among patients with Barrett's esophagus.
  2. ncbi In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
    ..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
  3. ncbi Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)
    Paul Swain
    Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
    Gastrointest Endosc 71:1290-3. 2010
    ..Remote manipulation of wireless capsule endoscopes might improve diagnostic accuracy and facilitate therapy...
  4. doi Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  5. pmc Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus
    Massimiliano Di Pietro
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, CB2 0XZ Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 109:9077-82. 2012
    Barrett esophagus (BE) is a human metaplastic condition that is the only known precursor to esophageal adenocarcinoma...
  6. ncbi A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
    Christopher J Peters
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    Gastroenterology 139:1995-2004.e15. 2010
    ..Current staging is limited in its ability to predict survival which has ramifications for treatment choices. The aim of this study was to generate and validate a molecular prognostic signature for esophageal adenocarcinoma...
  7. pmc Durability of radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Gastroenterology 141:460-8. 2011
    ..ablation (RFA) can eradicate dysplasia and intestinal metaplasia in patients with dysplastic Barrett's esophagus (BE), and reduce rates of esophageal adenocarcinoma...
  8. pmc Preliminary accuracy and interobserver agreement for the detection of intraepithelial neoplasia in Barrett's esophagus with probe-based confocal laser endomicroscopy
    Michael B Wallace
    Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Gastrointest Endosc 72:19-24. 2010
    ..Confocal laser endomicroscopy (CLE) is a rapidly emerging method for in vivo imaging of the GI tract...
  9. ncbi Esophageal acid exposure decreases intraluminal baseline impedance levels
    Boudewijn F Kessing
    Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, The Netherlands
    Am J Gastroenterol 106:2093-7. 2011
    ..The aim of this study was to investigate the baseline impedance in GERD patients, on and off proton pump inhibitor (PPI), and in healthy controls...
  10. ncbi Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011
    ..Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man...
  11. ncbi Confocal laser scanning fluorescence microscopy for in vivo determination of microvessel density in Barrett's esophagus
    V Becker
    Department of Medicine II, Technical University of Munich, Munich, Germany
    Endoscopy 40:888-91. 2008
    Angiogenesis has been reported to be an essential step in the progression of cancers arising from Barrett's esophagus. Confocal laser scanning microscopy (CLM) has the potential to perform in vivo microscopy to detect angiogenesis and ..
  12. ncbi Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    Weiguo Shu
    Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:1991-2000. 2007
    ....
  13. ncbi Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
    Claudia D Andl
    Gastroenterology Division, Abramson Cancer Center and Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:1824-30. 2003
    ..EGFR modulates cell migration through the up-regulation of matrix metalloproteinase 1. Taken together, the functional effects of EGFR overexpression help to explain its role in the initiating steps of esophageal squamous carcinogenesis...
  14. ncbi Probe-based confocal laser endomicroscopy compared with standard four-quadrant biopsy for evaluation of neoplasia in Barrett's esophagus
    M Bajbouj
    II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Endoscopy 42:435-40. 2010
    Surveillance of Barrett's esophagus includes endoscopic inspection with biopsy of suspicious lesions followed by four-quadrant biopsy of the remaining mucosa...
  15. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
  16. ncbi Etiology and pathogenesis of achalasia: the current understanding
    Woosuk Park
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 100:1404-14. 2005
    ..Current evidence suggests that the initial insult to the esophagus, perhaps a viral infection or some other environmental factor, results in myenteric plexus inflammation...
  17. pmc Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:4174-84. 2010
    ....
  18. pmc Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus
    Hejin P Hahn
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1006-15. 2009
    Barrett esophagus (BE) is defined by the presence of metaplastic esophageal columnar epithelium with goblet cells within endoscopically recognizable areas of the esophagus...
  19. ncbi Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus
    Ryu Ishihara
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
    J Gastroenterol Hepatol 25:1410-5. 2010
    ..The primary endpoint of the present study was to identify the significant NBI findings to diagnose esophageal mucosal high-grade neoplasia...
  20. ncbi Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus
    Naohiko Koide
    Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    J Gastroenterol 42:932-8. 2007
    ..We investigated clinicopathologic features in patients with esophageal small cell carcinoma (SCEC), and its proliferative activity and angiogenesis...
  21. pmc Management of esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    BMC Gastroenterol 11:46. 2011
    ..We examined the effectiveness of systemic steroid administration for control of postprocedural esophageal stricture after complete circular ESD...
  22. ncbi Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett's esophagus: a prospective randomized trial with crossover design
    A Hoffman
    I Med Clinic und Poliklinik, Institute for Statistics, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gastrointest Endosc 64:1-8. 2006
    ..In contrast to standard video endoscopy, magnifying endoscopy after local acetic acid application enables recognition of mucosal surface architecture...
  23. ncbi Primary malignant melanoma of the esophagus: a clinicopathologic study of a case with comprehensive literature review
    Michele Bisceglia
    Department of Pathology, Division of Anatomic Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    Adv Anat Pathol 18:235-52. 2011
    ..Primary malignant melanoma of the esophagus has been the subject mostly of case reports...
  24. ncbi Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?
    Gerrit J M Hemmink
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 103:2446-53. 2008
    ..Until now, it is unclear whether combined pH-impedance monitoring in these patients should be performed on or off PPI...
  25. pmc Consideration of dose limits for organs at risk of thoracic radiotherapy: atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus
    Feng Ming Spring Kong
    Department of Radiation Oncology, University of Michigan and Ann Arbor Veteran Affairs Medical System, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 81:1442-57. 2011
    ..dose limits and standardize the three-dimenional (3D) radiographic definition for the organs at risk (OARs) for thoracic radiotherapy (RT), including the lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus.
  26. ncbi The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas
    Chen Sung Lin
    Institute of Clinical Medicine, National Yang Ming University, Taipei 112, Taiwan
    J Thorac Cardiovasc Surg 139:189-197.e4. 2010
    ..The study objective was to evaluate the roles of mitochondrial DNA alterations in esophageal squamous cell carcinoma, with emphasis on the changes in the copy number and D310 variants of mitochondrial DNA...
  27. pmc A striking local esophageal cytokine expression profile in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 127:208-17, 217.e1-7. 2011
    ..Eosinophilic esophagitis (EE) is an emerging worldwide disease that mimics gastroesophageal reflux disease...
  28. ncbi The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection
    Satoru Hashimoto
    Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan
    Gastrointest Endosc 74:1389-93. 2011
    ....
  29. ncbi Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus
    Dominique P Coco
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:45-54. 2011
    Recent morphologic and molecular evidence suggests that dysplasia in Barrett esophagus (BE) begins in the bases of the crypts [crypt dysplasia (CD)] and progresses with time to involve the upper portions of the crypts and surface ..
  30. pmc MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers
    Thomas X Lu
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Allergy Clin Immunol 129:1064-75.e9. 2012
    ..The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored...
  31. ncbi Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus
    Beau A Standish
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Toronto, Ontario, Canada
    Gastrointest Endosc 66:326-33. 2007
    ..DOCT) is an imaging modality that allows assessment of the microvascular response during photodynamic therapy (PDT) and may be a powerful tool for treatment monitoring/optimization in conditions such as Barrett's esophagus (BE).
  32. ncbi Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 92:22-31. 2012
    ..These localization patterns are similar to those in the human esophagus. On day 7 under ALI culture, TJ proteins were detected in the superficial layers with functional properties, ..
  33. ncbi Perception of dysphagia: lack of correlation with objective measurements of esophageal function
    A Lazarescu
    Centre for Gastroenterological Research, KU Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:1292-7, e336-7. 2010
    ....
  34. pmc History, molecular mechanisms, and endoscopic treatment of Barrett's esophagus
    Stuart Jon Spechler
    VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Gastroenterology 138:854-69. 2010
    ..Association Institute's medical position statement and technical review on the management of Barrett's esophagus, which will be published in the near future...
  35. ncbi Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 13:5305-13. 2007
    The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear...
  36. ncbi Cdx2 as a marker of epithelial intestinal differentiation in the esophagus
    Roy W Phillips
    Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 27:1442-7. 2003
    The histologic diagnosis of Barrett's esophagus requires the presence of goblet cells, but this finding may not be the earliest indicator of intestinal metaplasia...
  37. ncbi Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitis
    Georg Dimcevski
    Department of Medical Gastroenterology, Haukeland University Hospital, Bergen, Norway
    Pancreas 35:22-9. 2007
    ..We, therefore, aimed at exploring the pain mechanisms in chronic pancreatitis (CP) using a multimodal and multitissue stimulation approach...
  38. pmc Induction of intestinalization in human esophageal keratinocytes is a multistep process
    Jianping Kong
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Carcinogenesis 30:122-30. 2009
    Barrett's esophagus (BE) is the replacement of normal squamous esophageal mucosa with an intestinalized columnar epithelium. The molecular mechanisms underlying its development are not understood...
  39. ncbi Endoscopic submucosal dissection of esophageal squamous cell neoplasms
    Mitsuhiro Fujishiro
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 4:688-94. 2006
    ..Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus.
  40. ncbi Intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil) after laparoscopic total gastrectomy
    Oh Jeong
    Department of Gastroenterologic Surgery, Chonnam National University Hwasun Hospital, 160, Ilsim Ri, Hwasun eup, Hwasun Gun, Jeollanam do, 519 809, Korea
    Surg Endosc 23:2624-30. 2009
    ..The authors report the newly developed reconstruction technique after LTG: intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil; Covidien, Mansfield, MA, USA)...
  41. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In Shh null mutants, we found that the trachea and esophagus do not separate properly and the lungs form a rudimentary sac due to failure of branching and growth after ..
  42. ncbi Effects of neoadjuvant radio-chemotherapy on 18F-FDG-PET in esophageal carcinoma
    I Brink
    Division of Nuclear Medicine, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Eur J Surg Oncol 30:544-50. 2004
    ..To investigate whether results of [F-18]-fluorodeoxy-d-glucose (FDG) positron emission tomography (PET) of esophageal cancer (EC) before and after neoadjuvant radio-chemotherapy correlate with histopathology after esophageal resection...
  43. ncbi Prevalence and risk factors for ischemia, leak, and stricture of esophageal anastomosis: gastric pull-up versus colon interposition
    John W Briel
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    J Am Coll Surg 198:536-41; discussion 541-2. 2004
    ..Reports of esophageal anastomotic complications often involve more gastric than colonic reconstructions and are incomplete because of fragmented followup by physicians unfamiliar with the surgical procedure...
  44. ncbi Influence of nasogastric tubes on gastroesophageal reflux in preterm infants: a multiple intraluminal impedance study
    Corinna S Peter
    Department of Neonatology and Pediatric Pulmonology, Hannover Medical School, Hannover, Germany
    J Pediatr 141:277-9. 2002
    ..infants underwent 48-hour recordings of multiple intraluminal impedance with the catheter tip in the lower esophagus or stomach for 24 hours each...
  45. pmc Relevance of ineffective oesophageal motility during oesophageal acid clearance
    M Simren
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Gut 52:784-90. 2003
    ..Intraluminal impedance allows non-radiological monitoring of movement of oesophageal liquids...
  46. pmc Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
    ....
  47. pmc Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model
    T Ohki
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Gut 55:1704-10. 2006
    ..However, after aggressive ESD, a major complication that arises is postoperative inflammation and stenosis that can considerably affect the patient's quality of life...
  48. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..Failure in septation between the trachea and the esophagus in Nkx2...
  49. ncbi IL-5 promotes eosinophil trafficking to the esophagus
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 168:2464-9. 2002
    Eosinophil infiltration into the esophagus occurs in a wide range of diseases; however, the underlying pathophysiological mechanisms involved are largely unknown...
  50. ncbi Radiofrequency ablation in Barrett's esophagus with dysplasia
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, CB 7080, Chapel Hill, NC 27599 7080, USA
    N Engl J Med 360:2277-88. 2009
    Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma...
  51. ncbi Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Differentiation 74:422-37. 2006
    ..folding of the endoderm into a foregut tube, and the subsequent separation of the foregut tube into trachea and esophagus. Defects in foregut morphogenesis underlie the constellation of human birth defects known as esophageal atresia (..
  52. pmc MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus
    Dipen M Maru
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Am J Pathol 174:1940-8. 2009
    Barrett's esophagus (BE)/Barrett's metaplasia (BM) is a recognized precursor of esophageal adenocarcinoma (EA) with an intermediary stage of dysplasia...
  53. ncbi Long-term clinical and pathologic response of Barrett's esophagus after antireflux surgery
    James M O'Riordan
    University Department of Surgery, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Am J Surg 188:27-33. 2004
    The impact of antireflux surgery on outcome in Barrett's esophagus, in particular its effect on both the regression of metaplasia and the progression of metaplasia through dysplasia to adenocarcinoma, remains unclear...
  54. ncbi High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry
    M Fox
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
    Neurogastroenterol Motil 16:533-42. 2004
    ..ii) The clinical value of HRM was assessed in a series of patients with endoscopy-negative dysphagia in whom conventional investigations had been non-diagnostic...
  55. pmc Bacterial biota in the human distal esophagus
    Zhiheng Pei
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:4250-5. 2004
    The esophagus, like other luminal organs of the digestive system, provides a potential environment for bacterial colonization, but little is known about the presence of a bacterial biota or its nature...
  56. ncbi Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    ..Therapies have included corticosteroids, elemental diet, and diet restriction. We report our experience with skin prick and atopy patch testing and food elimination diets in patients diagnosed as having EE...
  57. pmc Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    Nan Gao
    Department of Genetics, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 16:588-99. 2009
    ..We conclude that Cdx2 controls important aspects of intestinal identity and development, and that this function is largely independent of the enteric Hox code...
  58. ncbi Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
    Alex Straumann
    Department of Gastroenterology, Kantonsspital, Olten, Switzerland
    Gastroenterology 125:1660-9. 2003
    ..esophagitis is a chronic, increasingly recognized, interleukin 5-driven inflammatory disorder of the esophagus. The leading symptom in adults is uniform attacks of dysphagia, and the established histologic sign is a dense ..
  59. ncbi Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead?
    Robert H Riddell
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Gastroenterol 104:2588-94. 2009
    The definition of Barrett's esophagus (BE) varies worldwide, particularly with regard to the need to identify goblet cells in esophageal biopsies in order to diagnose this condition...
  60. ncbi Long-term outcome after endoscopic mucosal resection in patients with esophageal squamous cell carcinoma invading the muscularis mucosae or deeper
    Yuichi Shimizu
    Division of Endoscopy, Third Department of Internal Medicine, Hokkaido University Medical Hospital, Sapporo, Japan
    Gastrointest Endosc 56:387-90. 2002
    Endoscopic mucosal resection is recommended for squamous cell carcinoma of the esophagus confined to the lamina propria...
  61. ncbi Life isn't flat: taking cancer biology to the next dimension
    Keiran S M Smalley
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    In Vitro Cell Dev Biol Anim 42:242-7. 2006
    ..It is likely that the adoption of these and other 3D models will allow us to more closely re-create the behavior of the tumor in vivo which may lead to identifying better anticancer drug candidates at an earlier stage of development...
  62. ncbi Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells
    Tong Liu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 28:488-96. 2007
    Caudal-related homeobox 2 (Cdx2) has been suggested as an early marker of Barrett's esophagus (BE), which is the premalignant lesion of esophageal adenocarcinoma (EAC)...
  63. ncbi Efficacy of esophageal impedance/pH monitoring in patients with refractory gastroesophageal reflux disease, on and off therapy
    Jason M Pritchett
    Department of Internal Medicine, Voice Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 5280, USA
    Clin Gastroenterol Hepatol 7:743-8. 2009
    ..We studied whether combined impedance/pH monitoring in patients on therapy can predict acid reflux in patients off therapy and whether testing should be carried out when patients are on or off therapy...
  64. ncbi Prospective evaluation of narrow-band imaging endoscopy for screening of esophageal squamous mucosal high-grade neoplasia in experienced and less experienced endoscopists
    Ryu Ishihara
    Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Dis Esophagus 23:480-6. 2010
    ..To compare the diagnostic yield of NBI endoscopy for screening of squamous mucosal high-grade neoplasia of the esophagus between experienced and less experienced endoscopists...
  65. pmc Invasive thyroid cancer: management of the trachea and esophagus
    Daniel L Price
    Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Otolaryngol Clin North Am 41:1155-68, ix-x. 2008
    ..disease may involve critical structures in the central neck, including the recurrent laryngeal nerves, trachea, esophagus, and larynx, requiring surgery extending significantly beyond the thyroid gland...
  66. ncbi Intrathoracic esophageal replacement by in situ tissue-engineered esophagus
    Yuen Nakase
    Department of Surgery and Regenerative Medicine, Division of Surgery and Physiology of Digestive System, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Thorac Cardiovasc Surg 136:850-9. 2008
    This study aimed to evaluate in situ tissue-engineered esophagus in a canine model after experimental resection and replacement of a full circumferential defect of the intrathoracic esophagus.
  67. ncbi Cytokeratin and CDX-2 expression in Barrett's esophagus
    Jantine W P M van Baal
    Center for Experimental Molecular Medicine in Amsterdam, University Medical Center Utrecht, The Netherlands
    Scand J Gastroenterol 43:132-40. 2008
    Barrett's esophagus (BE) is a premalignant condition of the distal esophagus...
  68. ncbi Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients
    Danny Yakoub
    Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, United Kingdom
    Cancer Res 70:9129-36. 2010
    ..This indicates that metabolic profiling of tissue can potentially play a role in the surveillance of cancer by reporting on the phenotypic consequences of field cancerization...
  69. ncbi Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field
    Makoto Kammori
    Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Int J Mol Med 20:793-9. 2007
    ..This study furthers our understanding of the mechanism by which telomere shortening and chromosomal instability lead to carcinogenesis and field cancerization in the esophagus.
  70. ncbi Celiac disease and eosinophilic esophagitis: a true association
    Connull Leslie
    Department of Anatomic Pathology, Princess Margaret Hospital for Children, Subiaco, Australia
    J Pediatr Gastroenterol Nutr 50:397-9. 2010
    ..Recent reports suggest an association between the 2. The aim of this study was to estimate the prevalence of EE among children diagnosed with CD in our institution in the last 8 years...
  71. ncbi Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture
    Sabine Roman
    Digestive Physiology, Pavillon H, Hopital Edouard Herriot, Place d Arsonval, 69437 Lyon Cedex 03, France
    Am J Physiol Gastrointest Liver Physiol 293:G45-53. 2007
    ..Barrett's mucosa is a glandular metaplasia of the squamous epithelium that develops in the lower esophagus in the context of chronic, gastroesophageal reflux and is considered as a precursor for adenocarcinoma...
  72. pmc Ep-CAM expression in squamous cell carcinoma of the esophagus: a potential therapeutic target and prognostic marker
    Nikolas H Stoecklein
    Klinik für Allgemein und Viszeralchirurgie, Universitatsklinikum Dusseldorf, D 40225 Dusseldorf, Germany
    BMC Cancer 6:165. 2006
    ....
  73. ncbi Anatomy of right recurrent nerve node: why does early metastasis of esophageal cancer occur in it?
    Masaomi Mizutani
    Department of Gastroenterological Surgery, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    Surg Radiol Anat 28:333-8. 2006
    ..observations were performed on the recR and its surrounding lymphatics, especially afferent routes from the esophagus to the recR. Most afferent vessels of the recR originated from the right paratracheal node...
  74. ncbi Patients with nondysplastic Barrett's esophagus have low risks for developing dysplasia or esophageal adenocarcinoma
    Sachin Wani
    Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center and University of Kansas School of Medicine, Kansas City, Missouri, USA
    Clin Gastroenterol Hepatol 9:220-7; quiz e26. 2011
    ..The risks of dysplasia and esophageal adenocarcinoma (EAC) are not clear for patients with nondysplastic Barrett's esophagus (NDBE); the rate of progression has been overestimated in previous studies...
  75. ncbi Recent advancement of observing living cells in the esophagus using CM double staining: endocytoscopic atypia classification
    H Minami
    Digestive Disease Center, Showa University Northern Yokohama Hospital, Chigasaki Chuo, Tsuzuki, Yokohama, Kanagawa, Japan
    Dis Esophagus 25:235-41. 2012
    ..of ECS and endocytoscopic atypia (ECA) classification in various types of benign and malignant pathology in the esophagus. Consecutive 110 patients, who underwent ECS in our institution from March 2003 to December 2009, were included ..
  76. ncbi Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins
    Xin Chen
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G203-9. 2011
    ..In conclusion, acidic bile salts disrupted the squamous epithelial barrier function partly by modulating the amounts of claudin-1 and claudin-4. These results provide new insights for understanding the role of TJ proteins in esophagitis...
  77. ncbi Long-term survival after resection for small cell carcinoma of the esophagus
    S Yachida
    Department of Surgery, Faculty of Medicine, Kagawa Medical University, Japan
    Ann Thorac Surg 72:596-7. 2001
    ..A 77-year-old man had small cell carcinoma of the esophagus with extensive lymph node metastases...
  78. pmc Molecular pathways: pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett esophagus
    Liying Yang
    Department of Medicine and Pathology, New York University School of Medicine, New York, New York 10010, USA
    Clin Cancer Res 18:2138-44. 2012
    Esophageal adenocarcinoma is preceded by the development of reflux-related intestinal metaplasia or Barrett esophagus, which is a response to inflammation of the esophageal squamous mucosa, reflux esophagitis...
  79. ncbi Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material
    S Mueller
    Institute of Pathology, University of Munich, Munich, Germany
    Histopathology 53:676-84. 2008
    ..The aim was to compare histological parameters for the diagnosis of EO versus GORD on routinely taken biopsy specimens...
  80. pmc Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease
    Biljana Jovov
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 106:1039-47. 2011
    ..E-cadherin is a junctional protein important in barrier function in EE. Therefore, defects in barrier function in EE were sought in GERD as well as whether their presence correlated with abnormalities in e-cadherin...
  81. ncbi Microscopic esophagitis and Barrett's esophagus: the histology report
    Roberto Fiocca
    Department of Anatomic Pathology, University of Genova and S Martino University Hospital, Genoa, Italy
    Dig Liver Dis 43:S319-30. 2011
    ..In contrast, esophageal biopsy is mandatory when diagnosing Barrett's esophagus. High quality histology reports are necessary to provide information on diagnosis and can also be important for ..
  82. ncbi Occult dysplasia is disclosed by Lugol chromoendoscopy in alcoholics at high risk for squamous cell carcinoma of the esophagus
    R B Fagundes
    Dept of Gastroenterology, Hospital da Universidade Federal de Santa Maria, Brazil
    Endoscopy 31:281-5. 1999
    Squamous cell carcinoma of the esophagus (SCCE) becomes symptomatic at a late stage when the disease is already advanced, and this contributes to its poor prognosis...
  83. ncbi Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
    Barrett's esophagus (BE) is a metaplastic condition in which normal squamous esophageal epithelium is replaced by columnar epithelium...
  84. ncbi The utility of a novel narrow band imaging endoscopy system in patients with Barrett's esophagus
    Prateek Sharma
    Division of Gastroenterology and Hepatology, Department of Pathology, and Kansas Cancer Institute, University of Kansas School of Medicine and Veterans Affairs Medical Center, Kansas City, Missouri 64128 2295, USA
    Gastrointest Endosc 64:167-75. 2006
    ..A narrow band imaging (NBI) endoscopy system has been developed that allows superficial surface imaging of esophageal tissue in vivo...
  85. pmc Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol
    Gang Chen
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Antioxid Redox Signal 11:1083-95. 2009
    ..suggests that the high antioxidant capacity in EAC cells confers on them the ability to survive the oxidative microenvironment in the reflux esophagus, and that HNK is a promising compound to kill the transformed cells preferentially.
  86. ncbi A URA3 null mutant of Candida albicans (CAI-4) causes oro-oesophageal and gastric candidiasis and is lethal for gnotobiotic, transgenic mice (Tgepsilon26) that are deficient in both natural killer and T cells
    Edward Balish
    Department of Microbiology, Medical University of South Carolina, Charleston, SC 29403, USA
    J Med Microbiol 58:290-5. 2009
    ..albicans mutants to colonize and infect cutaneous, mucosal and systemic tissues and kill the susceptible host via a clinically common, natural route of infection; namely the alimentary tract...
  87. pmc Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia
    David H Wang
    Graduate Training Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Gastroenterology 138:1810-22. 2010
    The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown...
  88. ncbi Black esophagus: report of six cases and review of the literature, 1963-2003
    A B M Grudell
    Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Dis Esophagus 19:105-10. 2006
    Black esophagus is the uncommon endoscopic finding of extensive black discoloration of the esophageal mucosa, usually from acute esophageal necrosis...
  89. ncbi Acute esophageal necrosis: a rare syndrome
    Grigoriy E Gurvits
    Department of Gastroenterology, St Vincent s Medical Center, New York Medical College, 153 West 11th Street, NR 11, New York, NY10011, USA
    J Gastroenterol 42:29-38. 2007
    Acute esophageal necrosis, which presents as a black esophagus on endoscopy, is a rare disorder that is poorly described in the medical literature...
  90. ncbi Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus
    Nicholas J Clemons
    Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 303:G1335-46. 2012
    The molecular mechanism underlying the development of Barrett's esophagus (BE), the precursor to esophageal adenocarcinoma, remains unknown...
  91. ncbi Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors
    G Bahrenberg
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, Aachen, D 52057, Germany
    Biochem Biophys Res Commun 275:783-8. 2000
    ..Furthermore, PSCA mRNA was highly abundant in normal esophagus and stomach, but was undetectable in esophageal or gastric tumors...
  92. pmc Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
    Hui Ying Zhang
    Department of Medcine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, MC 111B1, Dallas VA Medical Ctr, 4500 South Lancaster Rd, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 295:G470-8. 2008
    ..in the signal transduction pathways activated by acid reflux that might underlie the development of Barrett's esophagus. To explore that hypothesis, we immortalized nonneoplastic, esophageal squamous cells from patients with ..
  93. ncbi Demonstration of substances of innate immunity in the esophageal epithelium of domesticated mammals. Part I--Methods and evaluation of comparative fixation
    Isabelle Nina Hornickel
    Institute for Anatomy, University of Veterinary Medicine Hannover Foundation, Bischofsholer Damm 15, Hannover, Germany
    Acta Histochem 113:163-74. 2011
    ..An application in routine diagnostic is not advisable, because of several variable parameters. It can be concluded that immunohistochemical results have always to be evaluated and discussed in close relation to the fixation medium used...
  94. pmc Black esophagus: acute esophageal necrosis syndrome
    Grigoriy E Gurvits
    Department of Gastroenterology, St Vincent s Medical Center New York Medical College, 170 West 12th Street, New York, NY 10011, USA
    World J Gastroenterol 16:3219-25. 2010
    Acute esophageal necrosis (AEN), commonly referred to as "black esophagus", is a rare clinical entity arising from a combination of ischemic insult seen in hemodynamic compromise and low-flow states, corrosive injury from gastric ..
  95. ncbi Multiple fields may offer better esophagus sparing without increased probability of lung toxicity in optimized IMRT of lung tumors
    Olivier Chapet
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 65:255-65. 2006
    ..To evaluate whether increasing numbers of intensity-modulated radiation therapy (IMRT) fields enhance lung-tumor dose without additional predicted toxicity for difficult planning geometries...
  96. pmc A unique esophageal motor pattern that involves longitudinal muscles is responsible for emptying in achalasia esophagus
    Su Jin Hong
    Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, South Korea
    Gastroenterology 139:102-11. 2010
    Achalasia esophagus is characterized by loss of peristalsis and incomplete esophagogastric junction (EGJ) relaxation...
  97. ncbi Trends in Barrett's esophagus diagnosis in Southern Europe: implications for surveillance
    Javier Alcedo
    Service of Digestive Diseases, Clínico Lozano Blesa Hospital, Institute of Health Sciences, CIBERehd, University of Zaragoza, Zaragoza, Spain
    Dis Esophagus 22:239-48. 2009
    The incidence of Barrett's esophagus (BE) and esophageal adenocarcinoma has increased in Western countries in recent decades...
  98. ncbi The role of radiofrequency ablation in the management of Barrett's esophagus
    William J Bulsiewicz
    GI Outcomes Training Program, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Gastrointest Endosc Clin N Am 21:95-109. 2011
    ..RFA) to be effective, safe, and well tolerated in the treatment of nondysplastic and dysplastic Barrett's esophagus (BE). The results found at academic medical centers have been reproduced in the community setting...
  99. ncbi Criteria for assessing esophageal motility in laparoscopic adjustable gastric band patients: the importance of the lower esophageal contractile segment
    Paul Robert Burton
    Centre for Obesity Research and Education CORE, Monash Medical School, The Alfred Hospital, Commercial RD Prahran, 3181, Melbourne, Australia
    Obes Surg 20:316-25. 2010
    ..Recent combined video fluoroscopic and high-resolution manometric studies have identified important components of esophageal function in LAGB patients...
  100. ncbi Assessment of intraluminal impedance for the detection of pharyngeal bolus flow during swallowing in healthy adults
    Taher I Omari
    Department of Paediatrics, University of Adelaide, and Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Adelaide, South Australia
    Am J Physiol Gastrointest Liver Physiol 290:G183-8. 2006
    ..In contrast, in the upper esophageal sphincter (UES) and proximal esophagus, the timing of impedance recovery correlated well with the timing of clearance of the bolus tail...
  101. ncbi Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010
    ..Here we directly compared gene expression profiles in human esophageal squamous cell carcinomas and in human fetal esophagus development...

Research Grants78

  1. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..and vascular injury followed by progressive fibrosis affecting skin and internal organs;most frequently esophagus, kidneys, heart, and lungs (I)...
  2. Developing Physics-Based Virtual Simulation Technology for Natural Orifice Transl
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..The most significant of these hurdles include (1) realistic modeling of multilayered hollow organs (e.g., esophagus, stomach, intestines, rectum and vagina) based on physical experiments;(2) simulation of the interaction of ..
  3. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..are diagnosed with cancers of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and testis, for which first-line therapy can potentially include platinating ..
  4. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..Other organs are affected too, including lung, heart, esophagus, intestine, and kidney. Many patients who suffer from scleroderma/SSc also have a loss of pulmonary function...
  5. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..Project Narrative This irradiation application addresses a critical problem in managing the side effects of thoracic radiotherapy for lung and esophagus cancer.
  6. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2013
    ..Approximately 10% of GERD patients develop Barrett's esophagus (BE), which is associated with nearly a 30-125-fold increased risk for the development of esophageal ..
  7. UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM
    Ezra Burstein; Fiscal Year: 2013
    ..inflammatory bowel disease;intestinal stem cells and malignant transformation in the GI tract, particularly the esophagus and colon;cancer prevention and screening;morphogenesis of the digestive system;obesity, liver steatosis, lipid ..
  8. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..We anticipate that this model could be easily expanded to other squamous cancers such as lung, esophagus, and uterine cervix...
  9. Mouse models for esophageal Cox-2 oxidative stress and DNA damage
    John P Lynch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE) is the replacement of the normal squamous esophageal epithelium with an intestinalized columnar epithelium...
  10. Cell death regulation in proteotoxic therapy
    Wei Xing Zong; Fiscal Year: 2013
    ..poorer prognosis in numerous advanced human cancers such as squamous cell carcinomas of lung, head and neck, and esophagus, as well as hepatocellular carcinoma and breast carcinoma...
  11. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2013
    ..During the past 5 years, we demonstrated that BRBs reduce NMBA-induced DNA damage in the rat esophagus and they inhibit proliferation, inflammation and angiogenesis, and stimulate apoptosis in premalignant ..
  12. Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus Patients
    HODA J BADR; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Highly prevalent in the U.S., Barrett's Esophagus (BE) results from chronic gastroesophageal reflux disease (GERD) and is a major risk factor for the development of esophageal adenocarcinoma (..
  13. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2012
    ..We will investigate upper and lower Gl tract pathologies including Barrett's esophagus, dysplasia, and adenocarcinoma, as well as dysplasia and adenocarcinoma in inflammatory bowel disease...
  14. Modeling oxidative stress and DNA damage using GI organotypic culture systems
    John P Lynch; Fiscal Year: 2013
    ..This work will greatly improve our ability to study, prevent, and treat Barrett's esophagus, IBD, and GVHD...
  15. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
    ..the oriental rat flea, Xenopsylla cheopis, formation of the biofilm leads to blockage of the valve between the esophagus and stomach of the flea, known as the proventriculus...
  16. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
  17. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..GI endoscopic procedures in the United States alone for the examinations of digestive tract including the esophagus, stomach, small intestine, colon, and rectum. The associated national cost is over $60 billion per year...
  18. Targeting the DNA damage response pathway for the treatment of HSV esophagitis
    Oleg Alekseev; Fiscal Year: 2013
    ..While HSV-1 is able to invade most mucocutaneous surfaces, the most common GI site of infection is the esophagus, where HSV-1 frequently causes recurrent epithelial ulceration...
  19. Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus Risk
    Marilie D Gammon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Flavonoids, esophageal/gastric cardia adenocarcinoma and Barrett's esophagus risk ABSTRACT...
  20. Characterization of lung cancer radiosensitizers from genome-wide RNAi screens
    David Kozono; Fiscal Year: 2013
    ..is limited due to infiltration of, or proximity to, radiosensitive structures including the lungs, spinal cord, esophagus and heart, resulting in locoregional failure rates of around 30% despite optimal treatment...
  21. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..large portions of the body surface area, mutilating scarring, joint contractures, and strictures of the esophagus, with opportunistic infections and aggressive squamous cell carcinoma as principal causes of early death...
  22. Investigation of the liver progenitor cell niche using CK19 lineage tracing
    EUGENE SCOTT SWENSON; Fiscal Year: 2011
    ..Adult stem cell niches have been identified in rapidly dividing tissues, such as the small intestine, skin and esophagus. Identification of adult stem cells in quiescent organs, such as the liver, has been more challenging...
  23. The effects of glucose on central vagal brainstem circuits
    KIRSTEEN NAIRN BROWNING; Fiscal Year: 2013
    ..The receptive relaxation reflex is a classical, vagally-mediated reflex activated upon distension of the esophagus (during swallowing, for example) that induces gastric relaxation and suppression of motility, allowing the ..
  24. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..will map the cells that produce these chemokines in the various mucosal tissues (oral cavity, bronchus, trachea, esophagus, gut and the female reproductive tract) by immunohistochemistry and/or in situ hybridization...
  25. Proteomics Biomarkers Development Laboratory
    Samir Hanash; Fiscal Year: 2009
    ..The tumor types investigated to date have included lung, colon and pancreas as well as breast, liver, esophagus and neuroblastoma, resulting in the identification of multiple antigens/autoantibodies that have potential ..
  26. Epidemiology and Outcomes of Digestive and Liver Diseases: A Mentoring Program
    Hashem B El-Serag; Fiscal Year: 2013
    ..to pursue independently funded patient oriented research in the epidemiology and outcomes of Barrett's esophagus (BE), hepatitis C virus (HCV) and hepatocellular carcinoma (HCC)...
  27. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..Signaling through endothelin receptor B (Ednrb) influences motility in the esophagus, stomach, small intestine, and colon...
  28. Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins
    Laura A Kresty; Fiscal Year: 2013
    ..disease (GERD), strongly correlate with EAC development and it's only known precursor lesion Barrett's esophagus (BE) via stimulation of cellular proliferation and apoptosis resistance...
  29. METABOLITE BIOIMARKERS IN THE DEVELOPMENT OF ESOPHAGEAL ADENOCARCINOMA
    Thomas L Vaughan; Fiscal Year: 2013
    ..Several major risk factors have been defined for EA and its precursor, Barrett's esophagus (BE), including reflux, Caucasian race, male gender, obesity, and smoking, but a key challenge remains the ..
  30. Predictors of Progression from Barrett's Esophagus to esophageal adenocarcinoma
    Brian J Reid; Fiscal Year: 2010
    ..responsive to Specific Challenge Topic: 03-CA-102 "Biologic Predictors of Progression in Barrett's Esophagus"...
  31. Tumor Progression of Nuclear EGFR in Breast Cancer
    Mien Chie Hung; Fiscal Year: 2013
    ..of this, we and others have shown that nuclear EGFR correlates with poor clinical outcomes in breast, ovarian, esophagus, and oral cancers...
  32. Role of Acid in the Development of Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic inflammation of the esophagus due to gastroesophageal reflux disease (GERD) contributes to the development of Barrett's esophagus and esophageal adenocarcinoma, a lethal tumor whose ..
  33. Molecular Pathobiology of Barrett's Tumorigenesis
    Wael El-Rifai; Fiscal Year: 2013
    ..reactive oxygen species (ROS) which leads to the development of esophageal metaplasia, known as Barrett's esophagus (BE)...
  34. Modulating cancer progression by adipogenic human adenovirus type 36
    Lei Cao; Fiscal Year: 2013
    ..is linked to an increased risk of certain types of cancer including postmenopausal breast, renal, ovarian, esophagus, pancreas, prostate, hepatobiliary, colorectal, and melanoma...
  35. Regulation of esophageal gene expression and function by KLF5 and p53
    Jonathan P Katz; Fiscal Year: 2013
    ..smoke, hot beverages, dietary nitroso-compounds, and refluxate of gastro-duodenal contents, and disorders of the esophagus are significant health problems in the U.S. and throughout the world...
  36. The Role of microRNA Alterations in Barrett's Carcinogenesis
    Stephen J Meltzer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Patients with Barrett's esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EAC), one of the most rapidly increasing cancers in developed nations...
  37. Chemoprevention of upper aerodigestive tract cancer by dietary zinc
    Louise Y Y Fong; Fiscal Year: 2013
    ..The inflammatory ZD esophagus has a distinct microRNA gene signature with overexpression of oncogenic miR-31 and miR-21, resembling that in ..
  38. The Role of IL-6/STAT3 in the Pathogenesis and Progression of Barrett's Esophagus
    Ronnie Fass; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE) is a metaplastic lesion of the distal esophagus that develops as a consequence of chronic gastroesophageal reflux disease (GERD)...
  39. Combinational Approaches to the Chemoprevention of Esophageal Cancer
    Tong Chen; Fiscal Year: 2012
    ..To identify cellular and molecular biomarkers of NMBA-induced tumorigenesis in the rat esophagus. Overall, a successful outcome of this hypothesis-driven preclinical study will provide important information ..
  40. Modulation of miR-31 by dietary zinc deficiency in rat esophageal carcinogenesis
    Louise Y Y Fong; Fiscal Year: 2012
    ..In rodents Zn-deficiency induces a hyperplastic phenotype in tongue and esophagus by causing cell proliferation and changes in gene expression...
  41. Exploring the Attitudes and Use of Family Cancer History and Biospecimen Collecti
    JANET JEANNE KELLY; Fiscal Year: 2013
    ..among AN people compared to US Whites for lung, colorectal, stomach, kidney, liver, gallbladder, pancreas, esophagus and oral/pharyngeal cancers...
  42. Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitis
    Seema S Aceves; Fiscal Year: 2013
    ..We will determine the expression of Cripto-1 in the esophagus of EE patients as compared with normal patients and define if Cripto-1 functions as a biomarker for EE...
  43. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
    ..b>Esophagus is suspected to be the cause of pain in these patients...
  44. IMAGE GUIDED IMMUNO THERAPY FOR INDUCIBLE ANTIGENS
    Dennis E Hallahan; Fiscal Year: 2012
    ..Poor prognostic cancers that are treated with radiation therapy include cancers of the lung, pancreas, esophagus, breast, brain and rectum...
  45. Posttranslational regulation of augurin, a new secretory tumor suppressor
    Akihiko Ozawa; Fiscal Year: 2013
    ..as a potential tumor suppressor, is a secretory molecule produced in the pituitary, brain, thyroid, and esophagus. It is implicated in a wide array of physiological processes, from ACTH release to tumor suppression, and is ..
  46. Clinical Studies on Bile Acids in Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2012
    ..provided by applicant): Project Summary/Abstract Gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE), which are exceptionally common disorders in Veteran patients, are strong risk factors for esophageal ..
  47. Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study (BEAGESS)
    David C Whiteman; Fiscal Year: 2011
    ..been found to be key modifiable risk factors for the development of EA and its main precursor, Barrett's esophagus (BE)...
  48. A Phase II Study to Test the Correlation of a Radiation Pneumonitis Imaging Bioma
    Thomas M Guerrero; Fiscal Year: 2010
    ..PET uptake (normalized to unirradiated lung) and the radiation dose in normal lung after radiotherapy for esophagus cancer. This metabolic response was found only in lung tissue...
  49. Mechanosensory Motor Neurons of Lower Esophageal Sphincter
    Ravinder K Mittal; Fiscal Year: 2013
    ..esophageal sphincter (LES) relaxation is the hallmark of achalasia and other spastic motor disorders of the esophagus. Too much LES relaxation (transient LES relaxation) leads to reflux disease...
  50. Epidemiology and Pathophysiology of Reflux Disease in African Americans
    Frank K Friedenberg; Fiscal Year: 2013
    ..The study will also give insight into the physical changes in the stomach and esophagus which occur as a result of weight loss in patients with reflux disease.
  51. The Epidemiology of Adipokines in Barrett's Esophagus
    Joel H Rubenstein; Fiscal Year: 2011
    ..Any such strategy will depend on identifying patients at risk for EAC. Barrett's esophagus (BE) is the accepted precursor of EAC...
  52. Basic and Clinical Studies on the Role of Bile Acids in Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2013
    Project Summary/Abstract Gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE), which are exceptionally common disorders in adult Americans, are strong risk factors for esophageal adenocarcinoma...
  53. Toll-like Receptor Signaling in the Esophageal Epithelium
    Mei Lun Wang; Fiscal Year: 2013
    ..to its significant socioeconomic burden, longstanding GERD esophagitis is a risk factor for Barrett's esophagus, a premalignant condition associated with the development of esophageal adenocarcinoma...
  54. Normal Tissue Complication Modeling for Radiotherapy
    Joseph Deasy; Fiscal Year: 2009
    ..For lung treatment plans, we will recompute lung and esophagus dose-volume histograms using a novel Monte Carlo-based technique, to improve the consistency and accuracy of the ..
  55. The temporal epigenomic program of Barrett's neoplastic progression
    Stephen J Meltzer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE), a sequela of chronic gastroesophageal reflux disease (GERD), is a premalignant condition that increases an individual's chance of developing esophageal ..
  56. The Role of Periostin and Th2 Cytokines in Eosinophilic Esophagitis Fibrogenesis
    Edaire Cheng; Fiscal Year: 2013
    ..esophageal epithelial cells expressing periostin, an extracellular matrix protein highly upregulated in the EoE esophagus. The chronic esophageal eosinophilia of EoE is associated with tissue remodeling characterized by a unique ..
  57. Role of Gata3 in pylorus development
    Ajay Prakash; Fiscal Year: 2013
    ..in previously undescribed superficial cord-like structures composed of smooth muscle cells that connect the esophagus to the pyloric region...
  58. DNA Damage Response Markers in Barrett's Esophagus
    Gregory H Enders; Fiscal Year: 2010
    ..Intestinal metaplasia, a condition commonly referred to as Barrett's esophagus, is associated with increased risk of EAC...
  59. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag
    HANNE GRON; Fiscal Year: 2010
    ..sales of nearly $1B, BMP-2 has been shown to trigger bone formation at ectopic sites, such as the trachea or esophagus, when not used precisely as directed by its labeling...
  60. Roles of hedgehog signaling in foregut development
    JOHN A KLINGENSMITH; Fiscal Year: 2013
    ..The rostral endodermal foregut tube divides into ventral respiratory (larynx and trachea) and dorsal alimentary (esophagus and stomach) components...
  61. Comparative Effectiveness of Screening and Surveillance Endoscopy
    Hashem B El Serag; Fiscal Year: 2010
    ..frequency, intensity) is unclear due to lack of strong evidence-based findings for GERD or Barrett's esophagus (BE) population at risk of EA...
  62. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2010
    ..engineered mouse model through tissue specific ablation of p120ctn, resulting in inflammation and cancer in the esophagus. Therefore, we hypothesize that p120ctn regulates tumor cell migration and invasion by its ability to modulate ..
  63. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2006
    ..and contraction of the CD in relationship to the LES, the compressive effect and forces of the CD on the distal esophagus, the role of the CD in antegrade movement of liquids and the role of the CD in induced relaxation of the GEJHPZ ..
  64. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2009
    ..is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE). Our preliminary study in elderly male veterans found two types of microbiotas in the esophagus...
  65. Clinical Risk Factors for Barretts Esophagus in a Primary Care Setting
    Blair Jobe; Fiscal Year: 2009
    ..Most patients who develop esophageal adenocarcinoma (EAC) are unaware of the presence of Barrett's esophagus (BE) prior to cancer diagnosis, and 57% have never reported chronic symptoms of gastroesophageal reflux disease (..
  66. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    ..improvement in survival of patients with cancers detected by routine endoscopic surveillance for Barrett's esophagus. In spite of these efforts, the majority of patients who develop esophageal adenocarcinoma are unaware of the ..
  67. Artificial Hand's Seeing Fingers: A New Device for Ingested Foreign Bodies Remova
    VLADIMIR RUBTSOV; Fiscal Year: 2010
    ..It is also the most difficult scenario because the contracted esophagus holds the object with substantial force...
  68. Influence of acid reflux on stromal epithelial interaction in Barrett?s esophagus
    GANAPATHY PRASAD; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Barrett's esophagus (BE) is an important risk factor for esophageal adenocarcinoma. Duodenogastric reflux leads to chronic inflammation and the development of BE in a subset of patients1, 2...
  69. Transnasal Esophagoscopy vs. Esophageal Capsule Endoscopy for Barrett's Screening
    Amitabh Chak; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Metaplastic transformation of the esophagus, termed Barrett's esophagus (BE) is a premalignant condition with a 1 per 200 patient-years risk of malignant progression to esophageal adenocarcinoma...
  70. Animal Model of Barrett's Esophagus
    Xiaoxin Chen; Fiscal Year: 2003
    The aim of this project is to investigate the role of bile acids in the development of Barrett's esophagus (BE), and to develop an animal model for BE and esophageal adenocarcinoma (EAC)...
  71. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2007
    ..Approximately 10% of GERD patients develop Barrett's esophagus (BE) where esophageal squamous epithelium damaged by reflux esophagitis is replaced by a metaplastic, intestinal-..
  72. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2005
    Barrett's esophagus is a pre-malignant condition that predisposes to esophageal adenocarcinoma, which has one of the fastest rising incidence rates in the United States and has limited therapeutic options...
  73. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..cancers are the most rapidly increasing cancer in Caucasian males and are a consequence of Barrett's esophagus. Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)..
  74. Role of H. Pylori Infection in Esophageal Adenocarcinoma
    Kam Meng Tchou Wong; Fiscal Year: 2003
    ..Colonization with cagA+ strains has been shown to be inversely associated with reflux esophagitis and Barrett's esophagus. A lower prevalence of cagA+ Helicobacter pylori has been observed in patient with gastroesophageal reflux ..
  75. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    Thomas Vaughan; Fiscal Year: 2000
    DESCRIPTION: Barrett's esophagus is a metaplastic condition that develops in an estimated 10-20% of persons with long-standing gastroesophageal reflux disease (GERD)...
  76. Low-cost tethered capsule endoscope for screening for Barrett's esophagus
    Jason Dominitz; Fiscal Year: 2009
    ..EGD) is recommended by the American College of Gastroenterology to screen for Barrett's esophagus (BE) in patients with longstanding symptoms of gastroesophageal reflux disease, as BE is a documented risk ..
  77. Genetic Linkage Analysis of Barrett's Esophagus
    Yvonne Romero; Fiscal Year: 2005
    ..Barrett's esophagus, a premalignant lining of the esophagus, is the most robust risk factor for this highly lethal cancer...
  78. Modulation of DNA methylation status by dietary zinc: role in cancer prevention
    LOUISE FONG; Fiscal Year: 2009
    ..Our new data showed overexpression of DNA methyltransferase enzymes DNMT3A and DNMT1 in ZD versus ZS rat esophagus and their repression upon ZR...