ampulla of vater

Summary

Summary: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.

Top Publications

  1. pmc Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma
    Arne Westgaard
    Faculty of Medicine, University of Oslo, Rikshospitalet University Hospital, 0027 Oslo, Norway
    BMC Cancer 8:170. 2008
  2. ncbi Endoscopic management of adenoma of the major duodenal papilla
    Marc F Catalano
    St Luke s Medical Center, Milwaukee, Wisconsin, USA
    Gastrointest Endosc 59:225-32. 2004
  3. ncbi Pathogenesis of carcinoma of the papilla of Vater
    Hans Peter Fischer
    Department of Pathology, University of Bonn, Sigmund Freud Str 25, D 53127, Bonn, Germany
    J Hepatobiliary Pancreat Surg 11:301-9. 2004
  4. ncbi Phenotypic and genotypic characterization of carcinomas of the papilla of Vater has prognostic and putative therapeutic implications
    Ilona Kohler
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Clin Pathol 135:202-11. 2011
  5. ncbi Endoscopic resection of ampullary tumors: 12-year review of 21 cases
    Jaume Boix
    Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s n, 08916, Badalona, Barcelona, Spain
    Surg Endosc 23:45-9. 2009
  6. pmc Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment
    Satoshi Kondo
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Hepatobiliary Pancreat Surg 15:41-54. 2008
  7. ncbi Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?
    Arne Westgaard
    Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Ann Surg Oncol 20:430-9. 2013
  8. ncbi Tumors of the ampulla of vater: histopathologic classification and predictors of survival
    Jonathan T Carter
    Department of Surgery, University of California, San Francisco, CA 94143 0475, USA
    J Am Coll Surg 207:210-8. 2008
  9. ncbi Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection
    Qi Lu Qiao
    Department of Surgery, First Hospital, Peking University, Beijing, 100034, China
    World J Surg 31:137-43; discussion 144-6. 2007
  10. ncbi Biliary tract cancer treatment: results from the Biliary Tract Cancer Statistics Registry in Japan
    Takukazu Nagakawa
    Department of Health Sciences, Kanazawa University, 5 11 80 Kodatuno, Kanazawa 920 9405, Japan
    J Hepatobiliary Pancreat Surg 9:569-75. 2002

Research Grants

Detail Information

Publications304 found, 100 shown here

  1. pmc Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma
    Arne Westgaard
    Faculty of Medicine, University of Oslo, Rikshospitalet University Hospital, 0027 Oslo, Norway
    BMC Cancer 8:170. 2008
    ....
  2. ncbi Endoscopic management of adenoma of the major duodenal papilla
    Marc F Catalano
    St Luke s Medical Center, Milwaukee, Wisconsin, USA
    Gastrointest Endosc 59:225-32. 2004
    ..This study describes endoscopic management and long-term follow-up of papillary tumors by 4 groups of expert pancreaticobiliary endoscopists...
  3. ncbi Pathogenesis of carcinoma of the papilla of Vater
    Hans Peter Fischer
    Department of Pathology, University of Bonn, Sigmund Freud Str 25, D 53127, Bonn, Germany
    J Hepatobiliary Pancreat Surg 11:301-9. 2004
    ..Consequently, the histologic classification should reflect the histogenesis of ampullary tumors from the two different types of papillary mucosa...
  4. ncbi Phenotypic and genotypic characterization of carcinomas of the papilla of Vater has prognostic and putative therapeutic implications
    Ilona Kohler
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Clin Pathol 135:202-11. 2011
    ..Besides the poorly differentiated CPV, the most common KRAS wild type makes them a putative target for an anti-epidermal growth factor receptor therapy...
  5. ncbi Endoscopic resection of ampullary tumors: 12-year review of 21 cases
    Jaume Boix
    Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s n, 08916, Badalona, Barcelona, Spain
    Surg Endosc 23:45-9. 2009
    ..Endoscopic snare papillectomy is increasingly performed with curative intent for benign papillary tumors. This study aimed to evaluate the outcome of endoscopic resection for ampullary tumors at a single center...
  6. pmc Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment
    Satoshi Kondo
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Hepatobiliary Pancreat Surg 15:41-54. 2008
    ..The prognostic factors after resection for ampullary carcinoma include lymph node metastasis, pancreatic invasion, and perineural invasion...
  7. ncbi Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?
    Arne Westgaard
    Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Ann Surg Oncol 20:430-9. 2013
    ..We evaluated whether the histologic type itself is more important for long-term survival than the fact that the tumor originated in the ampulla...
  8. ncbi Tumors of the ampulla of vater: histopathologic classification and predictors of survival
    Jonathan T Carter
    Department of Surgery, University of California, San Francisco, CA 94143 0475, USA
    J Am Coll Surg 207:210-8. 2008
    ..The histology and clinical behavior of ampullary tumors vary substantially. We speculated that this might reflect the presence of two kinds of ampullary adenocarcinoma: pancreaticobiliary and intestinal...
  9. ncbi Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection
    Qi Lu Qiao
    Department of Surgery, First Hospital, Peking University, Beijing, 100034, China
    World J Surg 31:137-43; discussion 144-6. 2007
    The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms...
  10. ncbi Biliary tract cancer treatment: results from the Biliary Tract Cancer Statistics Registry in Japan
    Takukazu Nagakawa
    Department of Health Sciences, Kanazawa University, 5 11 80 Kodatuno, Kanazawa 920 9405, Japan
    J Hepatobiliary Pancreat Surg 9:569-75. 2002
    ..The Japanese classification of lymph nodes was also considered on the basis of the results of this study...
  11. ncbi The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis
    Young Hoon Roh
    Department of Surgery, Dong A University College of Medicine, Busan, Korea
    Hepatogastroenterology 54:1641-4. 2007
    ..expression patterns and patient survival for the intestinal type (IT) and the pancreatobiliary type (PT) of ampulla of Vater carcinoma. Ampulla of Vater carcinoma can be classified histologically into either IT or PT...
  12. ncbi Endoscopic versus surgical ampullectomy: an algorithm to treat disease of the ampulla of Vater
    Eugene P Ceppa
    Department of General Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg 257:315-22. 2013
    ..The objective of this study was to compare the effectiveness, morbidity, and mortality associated with endoscopic ampullectomy (EA) and surgical ampullectomy (SA)...
  13. ncbi Reclassification of tumour origin in resected periampullary adenocarcinomas reveals underestimation of distal bile duct cancer
    E Pomianowska
    Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
    Eur J Surg Oncol 38:1043-50. 2012
    ..The proximity of the structures of possible origin renders it difficult to obtain a correct diagnosis, which might lead to inconsistencies in reported data and inappropriate adjuvant treatment...
  14. ncbi Safety and long-term efficacy of transduodenal excision for tumors of the ampulla of Vater
    S Posner
    Division of Gastrointestinal Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA
    Surgery 128:694-701. 2000
    ..Postoperative endoscopic surveillance is mandatory to identify recurrent tumors...
  15. ncbi Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer
    Woo Seok Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    J Surg Oncol 105:266-72. 2012
    ..The aims of this study were to identify those factors that affect recurrence after curative resection and to investigate differences between the clinicopathologic features of these two pathologic subtypes...
  16. ncbi Can endoscopic resection be applied for early stage ampulla of Vater cancer?
    Sun Young Lee
    Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea
    Gastrointest Endosc 63:783-8. 2006
    Although endoscopic resection can provide a wide tumor resection with a negative resection margin, it is not yet recommended as a curative therapy for ampulla of Vater cancer.
  17. ncbi Carcinoid tumors of the duodenum and ampulla of vater: a clinicomorphologic, immunohistochemical, and cell kinetic comparison
    L Bornstein-Quevedo
    Department of Pathology, , , Mexico City, Mexico
    Hum Pathol 32:1252-6. 2001
    Carcinoid tumors of the ampulla of Vater (ACs) differ from duodenal carcinoid tumors (DCs). A search for AC and DC was made between 1980 and 2000. The clinicopathologic features and follow-up were assessed...
  18. ncbi Carcinoid tumors of the duodenum and the ampulla of Vater: current diagnostic and therapeutic approach in a series of 8 patients. Case series
    George C Nikou
    Section of Gastrointestinal Neuroendocrinology, First Department of Propaedeutic Internal Medicine of Athens University Medical School, Laiko Hospital, Athens, Greece
    Int J Surg 9:248-53. 2011
    ..To describe the specific characteristics of duodenal/perivaterian carcinoids and to analyze the diagnostic/therapeutic approach...
  19. ncbi Large cell neuroendocrine carcinoma of the ampulla of vater
    Alberto Cavazza
    Department of Pathology, S Maria Nuova Hospital, Reggio Emilia, Italy
    Arch Pathol Lab Med 127:221-3. 2003
    We report a large cell neuroendocrine carcinoma arising in the ampulla of Vater. The patient, a 74-year-old woman, presented with a 3-cm ulcerated mass located in the ampullary region. She died of disease 8 months after surgery...
  20. ncbi Focal early stage cancer in ampullary adenoma: surgery or endoscopic papillectomy?
    Soon Man Yoon
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Gastrointest Endosc 66:701-7. 2007
    ..However, there are only anecdotal reports of endoscopic management of "focal" T1 ampullary cancer (T1 cancer), and radical surgery is still considered the only accepted treatment modality...
  21. ncbi Association of ampullary and colorectal malignancies
    Ananya Das
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer 100:524-30. 2004
    Because of the similarities in terms of carcinogenesis and natural history between cancer of the ampulla of Vater and colorectal cancer, the authors examined whether ampullary and colorectal malignancies occur in the same individuals at ..
  22. ncbi Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival
    Hui Ping Hsu
    Department of Surgery, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan
    Cancer Biol Ther 10:144-54. 2010
    ..Osteopontin (OPN) is overexpressed in several human cancer cells and in TAMs. Therefore, we set out to determine the role of OPN-expressing macrophages in cancer...
  23. ncbi Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer
    M M Aloysius
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre, National Institute for Health Research Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Surg 97:1269-78. 2010
    ..This study investigated the association of mucins and cluster of differentiation (CD) 56 with vascular and perineural invasion and survival in patients with periampullary cancer...
  24. pmc Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: Correlation with tumor progression and prognosis
    Yasunari Kawabata
    Department of Digestive and General Surgery, Shimane University Faculty of Medicine, 89 1 Enyacho, Izumo, Shimane 693 8501, Japan
    Diagn Pathol 5:75. 2010
    ..We assessed the expression of cytokeratin (CK) and apomucin (MUC) in ampullary carcinoma (AC) to develop a system for the classification of ACs on the basis of their clinical significance...
  25. ncbi Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater
    Sunil Krishnan
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 70:735-43. 2008
    ..We retrospectively compared treatment outcomes in patients treated with pancreaticoduodenectomy alone versus those who received additional adjuvant CRT...
  26. ncbi Outcome of pancreaticoduodenectomy and impact of adjuvant therapy for ampullary carcinomas
    J H Lee
    Departments of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 47:945-53. 2000
    ..To determine the clinical outcomes and potential impact of adjuvant chemoradiation in patients undergoing surgical resection of ampullary carcinoma...
  27. ncbi Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater
    Luciana Bertocco de Paiva Haddad
    Digestive Surgery Division, Department of Gastroenterology, University of Sao Paulo School of Medicine, R Aracaju 42, AP 41, Higienopolis, São Paulo 0501240030, Brazil
    J Gastrointest Surg 14:719-28. 2010
    ..The aim of the present study was to determine the best immunohistochemical panel for tumor classification and to analyze the survival of patients having these histological types of adenocarcinoma...
  28. ncbi Risk factors for acute pancreatitis after endoscopic papillary balloon dilation
    Masanori Sugiyama
    First Department of Surgery, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Hepatogastroenterology 50:1796-8. 2003
    ..Although EPBD (endoscopic papillary balloon dilation) may cause acute pancreatitis, risk factors for post-EPBD pancreatitis have not been well described. We retrospectively analyzed risk factors predictive of acute pancreatitis after EPBD...
  29. ncbi Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability
    Fausto Sessa
    Division of Anatomic Pathology, Department of Human Morphology, University of Insubria, Varese, Italy
    Virchows Arch 451:649-57. 2007
    ....
  30. ncbi Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater
    Michael J Overman
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 426, Houston, TX 77030, USA
    J Clin Oncol 27:2598-603. 2009
    Adenocarcinomas of the small bowel and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy...
  31. ncbi Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation: long-term results of EORTC trial 40891
    Hans G Smeenk
    Ann Surg 246:734-40. 2007
    ..The role of adjuvant chemoradiation in pancreatic cancer remains unclear. This report presents the long-term follow-up results of EORTC trial 40891, which assessed the role of chemoradiation in resectable pancreatic cancer...
  32. ncbi Endoscopic balloon dilation of the biliary sphincter compared to endoscopic biliary sphincterotomy for removal of common bile duct stones during ERCP: a metaanalysis of randomized, controlled trials
    Todd H Baron
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Medical Center, Rochester, Minnesota, USA
    Am J Gastroenterol 99:1455-60. 2004
    ..To compare the effect of endoscopic balloon dilation (EPBD) of the papilla with that of endoscopic biliary sphincterotomy (EST) in the treatment of patients with common bile duct stones...
  33. ncbi ERCP in patients with long-limb Roux-en-Y gastrojejunostomy and intact papilla
    Byron E Wright
    Department of Surgery, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    Gastrointest Endosc 56:225-32. 2002
    ..ERCP by means of long-limb Roux-en-Y surgical anastomoses has been reported primarily in patients with biliary or pancreatic anastamoses, but rarely in patients with an intact papilla...
  34. ncbi Improved survival for adenocarcinoma of the ampulla of Vater: fifty-five consecutive resections
    John P Duffy
    Section of Gastrointestinal Surgery, David Geffen School of Medicine, University of California Los Angeles, 90095, USA
    Arch Surg 138:941-8; discussion 948-50. 2003
    After resection of an adenocarcinoma of the ampulla of Vater, certain clinical and pathologic characteristics influence long-term survival.
  35. ncbi High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases
    Hind Nassar
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:588-94. 2005
    ..the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and large ..
  36. ncbi Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Halsted 610, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:379-87. 2010
    ..We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms...
  37. ncbi Carcinoid of the ampulla of Vater
    Mark Hartel
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastroenterol Hepatol 20:676-81. 2005
    Endocrine neoplasms only rarely occur at the ampulla of Vater, comprising mostly carcinoids and malignant carcinoids, as well as few cases of poorly differentiated endocrine carcinomas (small cell carcinomas)...
  38. ncbi Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms
    I Esposito
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Langenbecks Arch Surg 386:163-71. 2001
    ....
  39. ncbi What is an appropriate indication for endoscopic papillary balloon dilation?
    Masaaki Natsui
    Department of Internal Medicine, Niigata Prefectural Shibata Hospital, Shibata, Japan
    Eur J Gastroenterol Hepatol 14:635-40. 2002
    ..In this study, we have evaluated the efficacy and safety of EPBD compared with endoscopic sphincterotomy (EST)...
  40. ncbi Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders
    W C Su
    Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Dig Dis Sci 46:1387-92. 2001
    ..The results suggest overexpression of bFGF, PDGF, and HER2/Neu and the presence of K-ras mutation are important for carcinogenesis of bile duct cancers, and detection of the above abnormalities in bile is helpful for early diagnosis...
  41. ncbi The assessment of specimens procured by endoscopic ampullectomy
    Andrew M Bellizzi
    Dept of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Clin Pathol 132:506-13. 2009
    ..Of the patients, 33 (73%) had documented persistent disease. None of the histologic or clinical features had a statistically significant relationship with disease persistence...
  42. ncbi Safety and efficacy of curative intent surgery for peri-ampullary liver metastasis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Surg Oncol 102:256-63. 2010
    ..The management of patients with peri-ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri-ampullary liver metastasis...
  43. pmc Expression of cyclooxygenase-2 and its correlation with clinicopathologic factors of ampulla of vater cancer
    Hong Joo Kim
    Division of Gastroenterology and Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 18:218-24. 2003
    ..report for the expression of cyclooxygenase-2 (COX-2) and its clinicopathologic and biologic significance in ampulla of Vater cancer...
  44. ncbi A novel cell line and xenograft model of ampulla of Vater adenocarcinoma
    Claudio Sorio
    Dipartimento di Patologia, Universita di Verona, Strada Le Grazie, 37134, Verona, Italy
    Virchows Arch 444:269-77. 2004
    b>Ampulla of Vater cancers (AVC) are of clinical relevance, as they represent more than one-third of patients undergoing surgery for pancreaticoduodenal malignancies and have a better prognosis than periampullary cancers of ..
  45. ncbi Large-cell neuroendocrine carcinoma of the ampulla of Vater
    Z Stojsic
    Institute of Pathology, School of Medicine, University of Belgrade, Dr Subotica 1 II, 11000, Belgrade, Serbia
    Med Oncol 27:1144-8. 2010
    ..in extrapulmonary sites like the gastrointestinal tract, and only few examples have been described in the ampulla of Vater. A new case of large-cell neuroendocrine carcinoma of the ampulla of Vater in a 60-year-old man is reported...
  46. ncbi Standard whipple's operation versus pylorus preserving pancreaticoduodenectomy: a randomized controlled trial study
    Chatchai Srinarmwong
    Department of Surgery, Suratthani Hospital, Suratthani, Thailand
    J Med Assoc Thai 91:693-8. 2008
    ..A single-institution randomized controlled trial was conducted to compare the results of standard whipple operation (SW) with those of pylorus-preserving pancreaticoduodenectomy (PPPD)...
  47. ncbi Periampullary tumors: high-spatial-resolution MR imaging and histopathologic findings in ampullary region specimens
    Reiji Sugita
    Department of Radiology, NTT East Tohoku Hospital, 2 29 1 Yamatomachi, Wakabayashi ku, Sendai, Japan
    Radiology 231:767-74. 2004
    ....
  48. ncbi Imaging for the diagnosis and staging of periampullary carcinomas
    R M Walsh
    Department of General Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A80, Cleveland, OH 44195, USA
    Surg Endosc 17:1514-20. 2003
    ..The relative utility of each imaging modality is discussed regarding its role in diagnosis and staging. A general imaging approach to patients with a distal biliary obstruction also is presented...
  49. pmc Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation
    K Yamazaki
    Department of Pathology, Teikyo University, Ichihara Hospital, Ichihara, 299 0111, Japan
    Mol Pathol 56:336-41. 2003
    ..investigated the relation between cyclin D1 expression and clinicopathological parameters in carcinoma of the ampulla of Vater (CAV), and also assessed the relation between increased cyclin D1 expression and beta catenin/k-ras status in ..
  50. ncbi Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients
    Andrea Di Giorgio
    Department of Surgical Sciences, Digestive Surgery Unit, Catholic University School of Medicine, Largo F Vito 8, Rome 00168, Italy
    World J Surg 29:513-8. 2005
    ..Pancreatoduodenectomy is the treatment of choice for ampullary carcinoma and adenomas with high-grade dysplasia, with a good chance of long-term survival. Surgical resection remains the most important factor influencing outcome...
  51. ncbi Safety and long-term follow-up of endoscopic snare excision of ampullary adenomas
    P Katsinelos
    Department of Endoscopy, Central Hospital, Ethnikis Aminis 41, T K 54635, Thessaloniki, Greece
    Surg Endosc 20:608-13. 2006
    ..The aim of this retrospective study was to evaluate the safety and outcome of endoscopic snare resection of papillary adenomas in a Greek cohort of patients...
  52. ncbi Endoscopic resection of benign tumors of the papilla of vater
    S Bohnacker
    Department for Interdisciplinary Endoscopy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Endoscopy 38:521-5. 2006
    ..The following article details the approach to patients with benign papillary tumor and the technique of endoscopic papillectomy...
  53. ncbi Cancer of the ampulla of Vater: results of a 20-year population-based study
    A M Benhamiche
    Registre Bourguignon des Cancers Digestifs INSERM CRI 95 05, Faculte de Medecine, Dijon, France
    Eur J Gastroenterol Hepatol 12:75-9. 2000
    Relatively little attention has been given to the epidemiology and management of cancer of the ampulla of Vater.
  54. pmc Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Amol K Narang
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiat Oncol 6:126. 2011
    ..We combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation...
  55. ncbi Differential expression of metastasis-associated genes in papilla of vater and pancreatic cancer correlates with disease stage
    H Friess
    Department of Visceral and Transplantation Surgery and Institute of Pathology, University of Bern, Inselspital, Bern, Switzerland
    J Clin Oncol 19:2422-32. 2001
    ..Because metastasis formation is a critical step in tumor progression and a negative prognostic factor, we compared the expression of nm23-H1 and KAI1, two metastasis-suppressing genes, in papilla of Vater cancer and pancreatic cancer...
  56. pmc Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy
    Manisha Palta
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 19:1535-40. 2012
    ..Despite radical resection, survival rates remain low with high rates of local failure. We performed a single-institution outcomes analysis to define the role of concurrent chemoradiotherapy (CRT) in addition to surgery...
  57. ncbi Endoscopic ampullectomy: techniques and outcomes
    Roshan Patel
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Gastroenterol 46:8-15. 2012
    ..This study will focus on diagnosis and staging of ampullary adenomas and reviews indications for, and outcomes and complications of, endoscopic papillectomy...
  58. ncbi Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater
    Salvatore Piscuoglio
    Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    J Clin Pathol 65:140-5. 2012
    ..In colorectal cancer, CD44, CD133, CD166 and EpCAM have been proposed to represent CSC marker proteins and their expression has been shown to correlate with patient survival...
  59. ncbi [Tumors of Vater's ampulla]
    N Gassler
    Institut fur Pathologie, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Deutschland
    Pathologe 33:17-23. 2012
    ..Helpful in the decision are the relationship between the tumor centre and Vater's ampulla, the existence of premalignant lesions in the ampullary epithelium as well as histology and immunostaining of the tumor...
  60. ncbi Carcinoma of the ampulla of Vater: morphological and immunophenotypical classification predicts overall survival
    Sergio Morini
    Unit of Human Anatomy, CIR, Campus Bio Medico University of Rome, Rome, Italy
    Pancreas 42:60-6. 2013
    ..The objective of the study was to verify if histopathological differentiation of ampullary carcinoma after surgical resection may be related to survival...
  61. ncbi Adjuvant treatment for ampullary cancer. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011
    Richard Kim
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    JOP 12:362-3. 2011
    ..At the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting, the largest trial (Abstract #4006) evaluating adjuvant treatment of ampullary cancer was presented...
  62. ncbi [Resection of the ampulla of Vater]
    B Sastre
    Service de Chirurgie Digestive et Generale, Hôpital Sainte Marguerite Marseille
    J Chir (Paris) 143:246-50. 2006
  63. ncbi Surgical outcomes and prognostic factors for ampulla of Vater cancer
    S B Choi
    Department of Surgery, Korea University College of Medicine, Seoul, Korea
    Scand J Surg 100:92-8. 2011
    The prognosis for patients with ampulla of Vater cancer is better than other periampullary cancers...
  64. pmc Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases
    Nobuyuki Ohike
    Department of Pathology, Emory University Hospital, Atlanta, GA, USA
    Am J Surg Pathol 34:1731-48. 2010
    ..Here, we provide a detailed analysis of these neoplasms, which we propose to refer to as intra-ampullary papillary-tubular neoplasm (IAPN)...
  65. ncbi Prognostic significance of intratumoural microvessel density (IMD) in resected pancreatic and ampullary cancers to standard histopathological variables and survival
    A W Khan
    University Department of Surgery, Royal Free and University College Medical School, University College London, UK
    Eur J Surg Oncol 28:637-44. 2002
    ..The aim is to study IMD as a prognostic marker in resected ductal adenocarcinomas of head of pancreas and cancers of the ampullary region...
  66. ncbi Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater
    David K Chang
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia
    J Clin Oncol 31:1348-56. 2013
    Individuals with adenocarcinoma of the ampulla of Vater demonstrate a broad range of outcomes, presumably because these cancers may arise from any one of the three epithelia that converge at that location...
  67. ncbi beta-Catenin alteration in cancer of the ampulla of Vater
    M Kawakami
    First Dept of Surgery, Sapporo Medical University, Japan
    J Exp Clin Cancer Res 21:23-7. 2002
    To investigate the contribution of beta-catenin to the development of carcinoma of the ampulla of Vater, genetic alterations of beta-catenin gene, CTNNB-1 were searched...
  68. ncbi Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients
    Daniele Santini
    University Campus Bio Medico, Rome, Italy
    Clin Cancer Res 11:3784-9. 2005
    ....
  69. ncbi Ampullary and periampullary tumors: translational efforts to meet a challenge in diagnosis and treatment. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011
    Soonmo Peter Kang
    Merck Research Laboratories, Merck and Co, Inc Kenilworth, NJ, USA
    JOP 12:123-5. 2011
    ..Growing translational efforts in understanding this rare disease are exemplified by Abstracts #161 and #204 presented at the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium...
  70. pmc Clinicopathologic analysis of early ampullary cancers with a focus on the feasibility of ampullectomy
    Yoo Seok Yoon
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    Ann Surg 242:92-100. 2005
    ..The purpose of this study was to evaluate whether ampullectomy can substitute for pancreatoduodenectomy (PD) in early ampullary cancer by clinicopathologic study...
  71. ncbi The pylorus: take it or leave it? Systematic review and meta-analysis of pylorus-preserving versus standard whipple pancreaticoduodenectomy for pancreatic or periampullary cancer
    Paul J Karanicolas
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main St W, Hamilton, Ontario, L85 3Z5, Canada
    Ann Surg Oncol 14:1825-34. 2007
    ..Our objective was to determine the relative effects of pylorus-preserving pancreaticoduodenectomy (PPPD) and standard Whipple pancreaticoduodenectomy (SWPD) in patients with pancreatic or periampullary cancer...
  72. ncbi Incidence of cancer of the pancreas, extrahepatic bile duct and ampulla of Vater in the United States, before and after the introduction of laparoscopic cholecystectomy
    D R Urbach
    Department of Minimally Invasive Surgery and Surgical Research, Legacy Health System, Portland, Oregon, USA
    Am J Surg 181:526-8. 2001
    ..Some epidemiologic studies have identified cholecystectomy as a risk factor for pancreatic and biliary cancer...
  73. ncbi Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of Vater
    Hiroshi Terasawa
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    J Gastrointest Surg 10:823-8. 2006
    To determine the prognostic factors for patients with pathological T1 (pT1) carcinoma of the ampulla of Vater, 36 consecutive patients with carcinoma of the ampulla of Vater who underwent surgery were retrospectively analyzed in terms of ..
  74. ncbi Limitations of ampullectomy in the treatment of nonfamilial ampullary neoplasms
    Kevin K Roggin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 12:971-80. 2005
    ....
  75. ncbi Ectopic pancreas presenting as ampulla of Vater tumor
    Sheng Der Hsu
    Division of General Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Am J Surg 195:498-500. 2008
    ..Herein, we report a patient presenting with symptoms of ampullary tumor with obstructive jaundice, but the imaging study did not suggest the possibility of ectopic pancreas preoperatively...
  76. ncbi Large-cell neuroendocrine carcinoma of the major duodenal papilla: case report
    Mark Hartel
    Department of General Surgery, Institute of Pathology, University of Heidelberg, Germany
    Gastrointest Endosc 60:838-41. 2004
  77. ncbi Surgical technique for complete resection of the extrahepatic portion of the common bile duct and the ampulla of Vater for tumors of the ampulla of Vater
    Koichi Aiura
    Department of Surgery, Keio University School of Medicine, Shinanomachi 35, Shinjuku ku, Tokyo 160 8582, Japan
    J Hepatobiliary Pancreat Sci 18:276-81. 2011
    ..Local resection can be the procedure of choice in selected ampullary lesions for high-risk patients...
  78. pmc Is endosonography an effective method for detection and local staging of the ampullary carcinoma? A prospective study
    Panagiotis Skordilis
    University Hospital of Crete, Gastroenterology Department
    BMC Surg 2:1. 2002
    The relatively rare carcinoma of the ampulla of Vater is a neoplasia with a good prognosis compared to pancreatic cancer. Preoperative staging is important in planning the most suitable surgical intervention.
  79. pmc Small pancreatic and periampullary neuroendocrine tumors: resect or enucleate?
    Susan C Pitt
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 5124, USA
    J Gastrointest Surg 13:1692-8. 2009
    ..The aim of this study was to compare the outcomes of enucleation versus resection in patients with small pancreatic, ampullary, and duodenal neuroendocrine tumors (NETs)...
  80. ncbi Signet-ring cell carcinoma of the ampulla of Vater
    Lin Li
    Department of Pathology, North Shore University Hospital, Manhasset, New York 11030, USA
    Ann Clin Lab Sci 34:471-5. 2004
    ..SRCC of the ampulla of Vater is extremely uncommon with < 12 cases reported in the literature...
  81. ncbi Signet ring cell carcinoma of the ampulla of vater. A case report
    Yuji Ishibashi
    Division of Surgery, National Hospital Organization Disaster Medical Center, Tokyo 190 0014, Japan
    JOP 10:690-3. 2009
    Signet ring cell carcinoma of the ampulla of Vater is extremely rare and only 12 cases have previously been described in the English language literature...
  82. ncbi Incidental small ampullary somatostatinoma treated with ampullectomy 2 years after diagnosis
    G Guercioni
    Department of General Surgery, Ancona University Hospital, Ancona, Italy
    Dig Dis Sci 51:1767-72. 2006
    ..We report a case of a small pure somatostatin-producing neuroendocrine tumor of ampulla of Vater in a 54-year-old woman with neither neurofibromatosis nor somatostatinoma syndrome, "incidentally" discovered ..
  83. ncbi [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma]
    J Ferrando Marco
    Servicios de Anatomia Patologica, Hospital de Sagunto, Valencia
    Rev Esp Enferm Dig 99:235-8. 2007
    ..Both were confirmed by immunohistochemical analysis. According to the literature reviewed, this is the sixth reported case of this rare neoplastic association...
  84. ncbi A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer
    Seiko Hirono
    Second Department of Surgery, Wakayama Medical University School of Medicine, Wakayama, Japan
    Hepatogastroenterology 55:861-4. 2008
    ..As a result, it was concluded that this was a case of collision cancer of the middle bile duct and the papilla of Vater...
  85. ncbi Large cell neuroendocrine carcinoma of the ampulla of vater: Report of a case
    So Sen Huang
    Department of Surgery, Taichung Veterans General Hospital, Section 3, 160 Chung Kang Road, Taichung, Taiwan
    Surg Today 36:1032-5. 2006
    Large cell neuroendocrine carcinoma in the ampulla of Vater is rare and very different from the common ampullary adenocarcinoma. A 59-year-old man was admitted with obstructive jaundice...
  86. pmc Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature
    Eri Senda
    Department of Gastroenterology and Hepatology, Shinko Hospital, Kobe, Hyogo, Japan
    World J Surg Oncol 7:9. 2009
    ..One of the factors indicating the malignancy of these tumors is their size, and small ampullary carcinoid tumors have been sometimes treated by endoscopic resection...
  87. ncbi Adenosquamous cell carcinoma arising from the papilla major
    Nozomi Ueno
    Department of Surgery, Kita Osaka Hospital, Yodogawa ku, 532 0004 Osaka, Japan
    Oncol Rep 9:317-20. 2002
    ..This is the first report on a case of adenosquamous carcinoma of the papilla major...
  88. ncbi Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study
    Kei Ito
    Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan
    Gastrointest Endosc 66:740-7. 2007
    ..Endoscopic papillectomy is performed in selected patients with ampullary neoplasm, and, thus, accurate preoperative tumor staging is indispensable for its application...
  89. ncbi Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater
    N A van der Gaag
    Department of Surgery, Academic Medical Centre at the University of Amsterdam, Amsterdam, The Netherlands
    Br J Surg 95:735-43. 2008
    Lymphatic dissemination is an important predictor of survival in patients with adenocarcinoma of the ampulla of Vater. The incidence and clinical consequences of extracapsular lymph node involvement (LNI) in patients who undergo resection ..
  90. ncbi Balloon-catheter-assisted endoscopic snare papillectomy for benign tumors of the major duodenal papilla
    Koichi Aiura
    Center for Diagnostic and Therapeutic Endoscopy, Keio University Hospital, Tokyo, Japan
    Gastrointest Endosc 57:743-7. 2003
    ..An endoscopic snare papillectomy technique was devised using a balloon catheter inserted into the common bile duct to more efficiently resect papillary tumors en bloc...
  91. ncbi The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater
    Seung Tae Kim
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, South Korea
    Med Oncol 27:1149-54. 2010
    Adenocarcinoma arising from the ampulla of Vater is a rare neoplasm that accounts for only 0.2% of all gastrointestinal tract malignancies and has limited data regarding its frontline therapy...
  92. ncbi Transduodenal local resection for low-risk group ampulla of vater carcinoma
    Joon Seong Park
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Laparoendosc Adv Surg Tech A 17:737-42. 2007
    Carcinoma of the ampulla of Vater has a more favorable prognosis, compared to other malignant tumors of the periampullary region, because it usually presents with symptoms in the early stage...
  93. ncbi Pancreas-preserving biliary amputation with pancreatic diversion: a new surgical technique for complete resection of the intrapancreatic biliary system
    Satoshi Kondo
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine N15 W7 Kita ku, Sapporo 060 8638, Japan
    Hepatogastroenterology 51:1255-8. 2004
    ..Pancreas-preserving biliary amputation has been developed as an organ-preserving procedure alternative to pancreatoduodenectomy. Indications, methods of pancreatic reconstruction, and long-term results require further study...
  94. pmc Signet-ring cell carcinoma of ampulla of Vater: contrast-enhanced ultrasound findings
    Jin Mei Gao
    Department of Ultrasound, Shengjing Hospital of China University, Shenyang, Liaoning Province, China
    World J Gastroenterol 15:888-91. 2009
    Signet-ring cell carcinoma (SRCC) of ampulla of Vater is extremely uncommon, and less than 15 cases have been reported so far in literature. It mainly occurs in elderly people (median age 57 years)...
  95. ncbi Reappraisal of endosonography of ampullary tumors: correlation with transabdominal sonography, CT, and MRI
    Chien Hua Chen
    Digestive Disease Center, Changhua Show Chwan Memorial Hospital, Changhua 500, Taiwan
    J Clin Ultrasound 37:18-25. 2009
    ..To reappraise the accuracy of transabdominal sonography (US), CT, MRI, and endosonography (EUS) in the diagnosis and staging of ampullary tumors...
  96. ncbi Feasibility of endoscopic papillectomy in early stage ampulla of Vater cancer
    Sang Myung Woo
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 24:120-4. 2009
    ..The present study was designed to assess the factors that predict malignancy and lymph node metastasis and to suggest potential indications for endoscopic papillectomy by analyzing clinicopathological data...
  97. ncbi Local resection of ampullary tumors
    Adam T Meneghetti
    Department of Surgery, University of California San Francisco, San Francisco VA Medical Center, California 94121 0112, USA
    J Gastrointest Surg 9:1300-6. 2005
    ..No adenomas recurred as carcinomas, suggesting that local resection is appropriate for these tumors in the absence of dysplasia or atypia on preoperative biopsies...
  98. pmc Carcinoid of the ampulla of Vater: morphologic features and clinical implications
    George A Poultsides
    Department of Surgery, University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    World J Gastroenterol 12:7058-60. 2006
    Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice...
  99. ncbi Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours
    Jaihwan Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Dig Liver Dis 43:965-70. 2011
    ..Neuroendocrine tumours very rarely occur in the biliary tract; information about them is limited...
  100. ncbi Carcinoids and high-grade neuroendocrine carcinomas of the ampulla of vater: a comparative analysis of 139 cases from the surveillance, epidemiology, and end results program-a population based study
    Jorge Albores-Saavedra
    Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga, Tlalpan, Mexico
    Arch Pathol Lab Med 134:1692-6. 2010
    Neuroendocrine tumors of the ampulla of Vater constitute a heterogeneous group of neoplasms clinically and morphologically. Because they are rare, little is known about their demographics and biologic behavior.
  101. ncbi Gross appearance of the ampullary tumor predicts lymph node metastasis and outcome
    Masato Kayahara
    Division of Cancer Medicine, Department of Gastroenterological Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan masatok staff kanazawa u ac jp
    Dig Surg 27:127-31. 2010
    ..Patterns of lymph node involvement in carcinoma of the papilla of Vater (CPV) have not been studied in detail to date, and factors associated with lymphatic metastases and surgical outcome of this disease remain to be determined...

Research Grants3

  1. INJURY TO LIVER SINUSOIDAL ENDOTHELIAL CELLS
    Steven Strasberg; Fiscal Year: 2003
    ..A potentially beneficial improvements in preservation solutions are identified they will be tested in whole isolated livers and by transplantation in the rat. ..
  2. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. DIET AND DURATION OF CERVICAL HPV INFECTION
    MARC GOODMAN; Fiscal Year: 2009
    ....