gallbladder

Summary

Summary: A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.

Top Publications

  1. ncbi Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Gastroenterology 114:755-63. 1998
  2. pmc The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
    Tingting Li
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 9050, USA
    Mol Endocrinol 25:1066-71. 2011
  3. ncbi The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract
    Serge J L B Zweers
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 55:575-83. 2012
  4. ncbi Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization
    Hirdesh Uppal
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hepatology 47:1331-42. 2008
  5. ncbi Identification of a hormonal basis for gallbladder filling
    Mihwa Choi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Med 12:1253-5. 2006
  6. ncbi Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
    Dong Cai Liu
    Department of Geriatric Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Cancer Biomark 8:113-21. 2010
  7. ncbi Inhibitory effect of Survivin promoter-regulated oncolytic adenovirus carrying P53 gene against gallbladder cancer
    Chen Liu
    Department of Biliary Surgery, Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai 200438, China
    Mol Oncol 5:545-54. 2011
  8. ncbi Interstitial Cajal-like cells in human gallbladder
    Mihail E Hinescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, PO Box 35 29 Bucharest 35, Romania
    J Mol Histol 38:275-84. 2007
  9. pmc Investigation of the mechanisms by which Listeria monocytogenes grows in porcine gallbladder bile
    Georgina C Dowd
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Infect Immun 79:369-79. 2011
  10. ncbi Gallstone disease
    H U Marschall
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Intern Med 261:529-42. 2007

Detail Information

Publications293 found, 100 shown here

  1. ncbi Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Gastroenterology 114:755-63. 1998
    Cancer of the gallbladder is the number one cause of cancer mortality in Chilean women...
  2. pmc The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
    Tingting Li
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 9050, USA
    Mol Endocrinol 25:1066-71. 2011
    ..However, TGR5 is also highly expressed in gallbladder, where its functions are less well characterized...
  3. ncbi The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract
    Serge J L B Zweers
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 55:575-83. 2012
    ..FGF19 messenger RNA was found to be abundantly expressed in the human gallbladder and in the common bile duct, with only minor expression observed in the ileum...
  4. ncbi Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization
    Hirdesh Uppal
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hepatology 47:1331-42. 2008
    Gallstone disease is a hepatobiliary disorder due to biochemical imbalances in the gallbladder bile...
  5. ncbi Identification of a hormonal basis for gallbladder filling
    Mihwa Choi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Med 12:1253-5. 2006
    The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion...
  6. ncbi Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
    Dong Cai Liu
    Department of Geriatric Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Cancer Biomark 8:113-21. 2010
    In this study, we investigated the expressions of Msi-1 and ALDH1 in gallbladder adenocarcinoma (n=100), peritumoral tissues (n=46), adenomatous polyp (n=15), and chronic cholecystitis (n=35) using immunohistochemical method...
  7. ncbi Inhibitory effect of Survivin promoter-regulated oncolytic adenovirus carrying P53 gene against gallbladder cancer
    Chen Liu
    Department of Biliary Surgery, Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai 200438, China
    Mol Oncol 5:545-54. 2011
    ..b>Gallbladder cancer is characterized by rapid progress, poor prognosis, and aberrantly high expression of Survivin...
  8. ncbi Interstitial Cajal-like cells in human gallbladder
    Mihail E Hinescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, PO Box 35 29 Bucharest 35, Romania
    J Mol Histol 38:275-84. 2007
    We describe here an interstitial Cajal-like cell type (ICLC) in human gallbladder, resembling the archetypal enteric interstitial cells of Cajal...
  9. pmc Investigation of the mechanisms by which Listeria monocytogenes grows in porcine gallbladder bile
    Georgina C Dowd
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Infect Immun 79:369-79. 2011
    The food-borne pathogen Listeria monocytogenes is known to colonize the lumen of the gallbladder in infected mice and to grow rapidly in this environment (J. Hardy et al., Science 303:851-853, 2004)...
  10. ncbi Gallstone disease
    H U Marschall
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Intern Med 261:529-42. 2007
    ..This review summarizes current concepts on the pathogenesis of cholesterol gallstones with focus on the uptake and secretion of biliary lipids and special emphasis on recent studies into the genetic background...
  11. ncbi Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer
    Se Kook Kee
    Department of Anatomy, Kyungpook National University, Daegu 702 422, Korea
    Mol Cells 24:364-71. 2007
    ..the expression of RASSF1A protein, and the correlation between these and the clinicopathological features of gallbladder (GB) cancer in Korean patients...
  12. ncbi Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis
    Hiroe Ono
    Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 51:30-41. 2012
    b>Gallbladder cancer (GBC) is relatively rare but has a high mortality rate...
  13. ncbi VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium
    Nicolas Chignard
    INSERM, Paris, France, and Universite Pierre et Marie Curie, Paris, France
    Hepatology 42:549-57. 2005
    ..e., hepatocytes, bile duct, and gallbladder epithelial cells)...
  14. pmc Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA, USA
    Biochim Biophys Acta 1801:138-46. 2010
    We investigated the effect of gallbladder hypomotility on cholesterol crystallization and growth during the early stage of gallstone formation in CCK knockout mice...
  15. ncbi Imaging of adenomyomatosis of the gall bladder
    H Stunell
    Department of Radiology, Adelaide and Meath Hospital, Dublin, Ireland
    J Med Imaging Radiat Oncol 52:109-17. 2008
    ..A brief section on oral cholecystography to aid readers familiar with this technique in understanding the comparable imaging features on more modern imaging techniques is included...
  16. ncbi Gallbladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones
    P Portincasa
    University Medical School, Bari, Italy Hospital of Bisceglie, Italy University Hospital Utrecht, The Netherlands
    Eur J Clin Invest 30:317-24. 2000
    Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics.
  17. ncbi Peritoneal gallstones following laparoscopic cholecystectomy: incidence, complications, and management
    J C Woodfield
    HBP Upper GI Unit, Department of General Surgery, Auckland City Hospital, Park Road, 92024, Private Bag, Auckland, New Zealand
    Surg Endosc 18:1200-7. 2004
    ..Our aim was to quantify the likelihood, and to document the range, of subsequent complications...
  18. ncbi Role of mitochondria in spontaneous rhythmic activity and intracellular calcium waves in the guinea pig gallbladder smooth muscle
    Onesmo B Balemba
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, 89 Beaumont Ave, D406 Given Bldg, Burlington, VT 05405, USA
    Am J Physiol Gastrointest Liver Physiol 294:G467-76. 2008
    ..effect of mitochondrial inhibitors on spontaneous action potentials (APs), Ca(2+) flashes, and Ca(2+) waves in gallbladder smooth muscle (GBSM)...
  19. ncbi Review article: agents affecting gall-bladder motility--role in treatment and prevention of gallstones
    K J van Erpecum
    Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 14:66-70. 2000
    ..However, there are no long-term studies to prove that such a strategy prevents gallstone formation...
  20. ncbi Histologic analysis of chronic inflammatory patterns in the gallbladder: diagnostic criteria for reporting cholecystitis
    Juan José Barcia
    Catedra de Anatomia Patologica, Hospital de Clinicas Dr Manuel Quintela, Facultad de Medicina, Montevideo, Uruguay
    Ann Diagn Pathol 7:147-53. 2003
    ..Inflammatory disease is by far the most common pathology of the gallbladder. Terms for describing cholecystitis are numerous, thus there is no uniform terminology...
  21. pmc Aberrant presentation of the gallbladder during laparoscopic cholecystectomy
    Irfan Qureshi
    University of Florida College of Medicine Jacksonville, Jacksonville, Florida 32209, USA
    JSLS 13:605-7. 2009
    Aberrant gallbladder transposed to the left side is a rare congenital anomaly that has been seen in as many as 0.7% of the population...
  22. ncbi Immunohistochemical study of Dicer and Drosha expression in the benign and malignant lesions of gallbladder and their clinicopathological significances
    Guo Shun Shu
    Department of Geriatric Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Pathol Res Pract 208:392-7. 2012
    ..Their expressions in gallbladder cancer have not been investigated...
  23. pmc Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease
    B Lavoie
    Department of Anatomy and Neurobiology, University of Vermont School of Medicine, Burlington, VT 05405, USA
    Neurogastroenterol Motil 24:e313-24. 2012
    BACKGROUND; Decreased gallbladder smooth muscle (GBSM) contractility is a hallmark of cholesterol gallstone disease, but the interrelationship between lithogenicity, biliary stasis, and inflammation are poorly understood...
  24. ncbi Endoscopic gallbladder drainage for management of acute cholecystitis
    Takao Itoi
    Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan
    Gastrointest Endosc 71:1038-45. 2010
    Nonoperative gallbladder drainage methods for acute cholecystitis include percutaneous transhepatic gallbladder drainage and percutaneous transhepatic gallbladder aspiration, endoscopic nasogallbladder drainage and gallbladder stenting ..
  25. ncbi Ultrastructure of Myxidium trachinorum sp. nov. from the gallbladder of the lesser weever fish Echiichthys vipera
    E U Canning
    Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    Parasitol Res 85:910-9. 1999
    Myxidium trachinorum sp. nov. is described from the gallbladder of the lesser weever fish Echiichthys vipera. Pseudoplasmodia attach themselves to the gallbladder epithelium by filose processes, which are inserted between host cells...
  26. ncbi Enteroscopic cyanoacrylate sclerotherapy of jejunal and gallbladder varices in a patient with portal hypertension
    S Getzlaff
    Dept. of Gastroenterology, City Hospital, Ludwigshafen am Rhein (University of Mainz Medical School, Germany
    Endoscopy 33:462-4. 2001
    ..We present here a report on the diagnosis and treatment of bleeding jejunal and gallbladder varices in a man with portal hypertension caused by chronic calcifying pancreatitis...
  27. ncbi Comparison of artificial neural networks with logistic regression in prediction of gallbladder disease among obese patients
    P L Liew
    Department of Pathology, En Chu Kong Hospital, Taipei Hsien, Taiwan
    Dig Liver Dis 39:356-62. 2007
    Obesity is a risk factor for gallbladder disease. The authors retrospectively analyse the prevalence and risk factors of gallbladder disease using logistic regression and artificial neural networks among obese patients in Taiwan.
  28. ncbi Cystogastrocolic fold and associated atrophy of the gallbladder
    N Pamidi
    Department of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal 576104, Karnataka, India
    Singapore Med J 49:e250-1. 2008
    ..We report the presence of a cystogastrocolic fold associated with an abnormally small gallbladder in a 50-year-old male cadaver...
  29. pmc Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/- female mice
    Chiara Gabbi
    Department of Biosciences and Nutrition, Karolinska Institutet, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 107:14763-8. 2010
    b>Gallbladder cancer is a highly aggressive disease with poor prognosis that is two to six times more frequent in women than men...
  30. ncbi [Precancerous lesions of the gallbladder]
    R Kianmanesh
    Service de Chirurgie Generale et Digestive, Hôpital Louis Mourier AP HP, Université Paris VII Colombes
    J Chir (Paris) 144:278-86. 2007
    ..Mini-review summarizes the epidemiology, predisposing and pre-cancerous conditions related to carcinoma of the gallbladder. In 75% of cases, gallbladder cancer is a cholangiocarcinoma, usually presenting in a late and advanced stage, ..
  31. ncbi E-cadherin and beta-catenin expression in normal, inflamed and cancerous gallbladder tissue
    Harald Puhalla
    Department of General Surgery, General Hospital, Medical University of Vienna, 1090 Vienna, Austria
    Anticancer Res 25:4249-54. 2005
    ..b>Gallbladder carcinoma (GBC) can develop during chronic inflammation from normal tissue...
  32. ncbi Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor
    C D Ulrich
    Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, MN 55905
    Biochem Biophys Res Commun 193:204-11. 1993
    Through binding to cholecystokinin (CCK) A receptors, CCK is an important physiologic regulator of both gallbladder contraction and pancreatic enzyme secretion...
  33. pmc Renal cell carcinoma with metastases to the gallbladder: four cases from the National Cancer Institute (NCI) and review of the literature
    Paul H Chung
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Urol Oncol 30:476-81. 2012
    We evaluate presentation and outcome of patients with metastatic RCC to the gallbladder from our institution and published literature.
  34. ncbi Significance of extensive surgery including resection of the pancreas head for the treatment of gallbladder cancer--from the perspective of mode of lymph node involvement and surgical outcome
    Ryoko Sasaki
    Department of Surgery I, Iwate Medical University, 19 1 Uchimaru, Morioka, 020 8505, Japan
    World J Surg 30:36-42. 2006
    ..of extensive surgery, including pancreas head resection, for more complete lymphadenectomy in the treatment of gallbladder carcinoma...
  35. ncbi A new species of Sphaeromyxa (Myxosporea: Sphaeromyxina: Sphaeromyxidae) in devil firefish, Pterois miles (Scorpaenidae), from the northern Red Sea: morphology, ultrastructure, and phylogeny
    A Diamant
    Israel Oceanographic and Limnological Research Ltd, National Center for Mariculture, Eilat 88112, Israel
    J Parasitol 90:1434-42. 2004
    Sphaeromyxa zaharoni n. sp. (Myxosporea) is described from the gallbladder of devil firefish, Pterois miles (Scorpaenidae), from coral reefs of the Gulf of Eilat, Israel, northern Red Sea...
  36. ncbi MUC 1 core protein as a marker of gallbladder malignancy
    M Ghosh
    Department of Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba Shi 305, Japan
    Eur J Surg Oncol 31:891-6. 2005
    The significance of MUC 1 expression in the gallbladder tissues in relation to cancer and non-cancer disease is not well understood. The aim of this study was to clarify the significance of MUC 1 expression.
  37. ncbi New species of Myxosporea from frogs and resurrection of the genus Cystodiscus Lutz, 1889 for species with myxospores in gallbladders of amphibians
    Ashlie Hartigan
    University of Sydney, New South Wales 2006, Australia
    Parasitology 139:478-96. 2012
    ..Spores of both species are produced in the gallbladder. Spores of C. axonis sp. n. possess distinct filiform polar appendages (FPA)...
  38. ncbi Sonographic diagnosis of biliary atresia in pediatric patients using the "triangular cord" sign versus gallbladder length and contraction
    Kimio Kanegawa
    Department of Radiology, Kobe Children s Hospital, 1 1 1 Takakuradai Suma ku, Kobe 654 0081, Japan
    AJR Am J Roentgenol 181:1387-90. 2003
    A retrospective review was performed to evaluate the importance of the "triangular cord" sign in comparison with gallbladder length and contraction for the diagnosis of biliary atresia in pediatric patients.
  39. ncbi Frequent and significant K-ras mutation in the pancreas, the bile duct, and the gallbladder in autoimmune pancreatitis
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Pancreas 38:890-5. 2009
    ..To assess the relationship between autoimmune pancreatitis (AIP) and pancreatic cancer, we analyzed K-ras mutation in the pancreatobiliary tissues of patients with AIP...
  40. ncbi Relationship between pain symptoms and referred sensory and trophic changes in patients with gallbladder pathology
    Maria Adele Giamberardino
    Ce S I, G d Annunzio Foundation, G D Annunzio University of Chieti, Pescara, Italy
    Pain 114:239-49. 2005
    The relationship was investigated between algogenic potential of gallbladder pathology and occurrence/extent of sensory and trophic changes in the referred area...
  41. ncbi Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor
    Torsten Plosch
    Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands
    Gastroenterology 126:290-300. 2004
    ..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen...
  42. ncbi Ultrasound measurement of gallbladder wall thickening as a diagnostic test and prognostic indicator for severe dengue in pediatric patients
    James A Colbert
    Stanford University School of Medicine, Stanford, CA, USA
    Pediatr Infect Dis J 26:850-2. 2007
    b>Gallbladder wall thickening measured by ultrasound was significantly associated with severe dengue, as well as with hallmark features of thrombocytopenia and elevated hematocrit/hemoconcentration, in children with suspected dengue in ..
  43. ncbi Gallbladder carcinoma: radiologic-pathologic correlation
    A D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 121, Washington, DC 20306 6000, USA
    Radiographics 21:295-314; questionnaire, 549-55. 2001
    Primary carcinoma of the gallbladder is an uncommon, aggressive malignancy that affects women more frequently than men. Older age groups are most often affected, and coexisting gallstones are present in the vast majority of cases...
  44. ncbi Salmonella infection of gallbladder epithelial cells drives local inflammation and injury in a model of acute typhoid fever
    Alfredo Menendez
    Michael Smith Laboratories, Division of Anatomy and Cell Biology, Life Sciences Centre, University of British Columbia, Vancouver, Canada
    J Infect Dis 200:1703-13. 2009
    The gallbladder is often colonized by Salmonella during typhoid fever, yet little is known about bacterial pathogenesis in this organ...
  45. pmc Percutaneous radiofrequency ablation of hepatocellular carcinomas adjacent to the gallbladder with internally cooled electrodes: assessment of safety and therapeutic efficacy
    Sang Won Kim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Radiol 10:366-76. 2009
    ..this study was to evaluate the safety and therapeutic efficacy of percutaneous radiofrequency (RF) ablation for the treatment of hepatocellular carcinomas (HCCs) adjacent to the gallbladder with the use of internally cooled electrodes.
  46. ncbi Lost gallstones in laparoscopic cholecystectomy: all possible complications
    Jörg Zehetner
    Department of Surgery, Ludwig Boltzmann Institute for Operative Laparoscopy, AKH Linz, Krankenhausstrasse 9, 4020 Linz, Austria
    Am J Surg 193:73-8. 2007
    ..The aim of this review is to categorize these complications and to evaluate the frequency and management of lost gallstones...
  47. pmc Helicobacter species and common gut bacterial DNA in gallbladder with cholecystitis
    Peren H Karagin
    Department of Medical Microbiology, Lund University, Solvegatan 23, SE 223 62 Lund, Sweden
    World J Gastroenterol 16:4817-22. 2010
    ..To analyze the association between Helicobacter spp. and some common gut bacteria in patients with cholecystitis...
  48. ncbi Coordinate regulation of gallbladder motor function in the gut-liver axis
    Piero Portincasa
    Department of Internal Medicine and Public Medicine, Clinica Medica A Murri, University of Bari Medical School, Bari, Italy
    Hepatology 47:2112-26. 2008
    ..In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease...
  49. ncbi Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells
    Baoli Qin
    First Department of Internal Medicine and Department of Biosystemic Science of Medicine, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, 812 8582, Higashi ku, Fukuoka, Japan
    Cancer Chemother Pharmacol 58:577-84. 2006
    ..In this study, we investigated the mechanistic role of Src and Ras, major oncogene products implicated in the pathogenesis of many human cancers in gefitinib sensitivity...
  50. ncbi Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids
    Benjamín Erranz
    Center for Cell Regulation and Pathology Joaquin V Luco, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, and Instituto Milenio de Biología Fundamental y Aplicada, Santiago, Chile
    J Lipid Res 45:2185-98. 2004
    Cholesterol crystal formation in the gallbladder is a key step in gallstone pathogenesis. Gallbladder epithelial cells might prevent luminal gallstone formation through a poorly understood cholesterol absorption process...
  51. ncbi Micronutrients, antioxidants, and carcinoma of the gallbladder
    Vijay Kumar Shukla
    Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    J Surg Oncol 84:31-5. 2003
    ..This study was undertaken to test the above hypothesis in patients with carcinoma of the gallbladder.
  52. ncbi Bile aspiration and hydrodissection to prevent complications in hepatic RFA close to the gallbladder
    Elena Levit
    Department of Diagnostic and Interventional Radiology, University Hospital, RWTH Aachen University, Aachen, Germany
    Acta Radiol 53:1045-8. 2012
    ..Its application, however, is limited by tumor size and location with lesions located within 1 cm to the gallbladder being at increased risk for complications.
  53. ncbi Management of cancer gallbladder found as a surprise on a resected gallbladder specimen
    Mahesh Chandra Misra
    All India Institute of Medical Sciences, New Delhi
    J Surg Oncol 93:690-8. 2006
    Carcinoma gallbladder is associated with an overall 5-year survival rate reported less than 5% due to late diagnosis. Advent of ultrasound scanning may help in detecting gallbladder polyps and an early gallbladder cancer...
  54. ncbi Endoscopic gallbladder stent placement for treatment of symptomatic cholelithiasis in patients with end-stage liver disease
    Christine Schlenker
    Division of Gastroenterology Hepatology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Gastroenterol 101:278-83. 2006
    ..We have found that placement of an endoscopic gallbladder stent is an alternative, less invasive treatment for cirrhotic patients with symptomatic gallbladder disease ..
  55. ncbi Laparoscopic partial cholecystectomy for the difficult gallbladder: a systematic review
    Daniel Henneman
    Department of Surgery, Sint Lucas Andreas Hospital, Jan Tooropstraat 164, 1061 AE Amsterdam, The Netherlands
    Surg Endosc 27:351-8. 2013
    ..An alternative approach aimed at preventing bile duct injury is laparoscopic partial cholecystectomy (LPC). The safety and efficacy of this procedure are unclear...
  56. ncbi Interstitial cells of Cajal are present in human extrahepatic bile ducts
    Omid Ahmadi
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, New Zealand
    J Gastroenterol Hepatol 25:277-85. 2010
    ..ICC were recently discovered in the wall of the human gallbladder. This study sought to determine whether ICC are present in human bile ducts.
  57. ncbi Microbiologic evaluation of gallbladder bile of healthy dogs and dogs with iatrogenic hypercortisolism: a pilot study
    P H Kook
    Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstr 260, CH 8057 Zurich, Switzerland
    J Vet Intern Med 24:224-8. 2010
    ..In dogs, an association between HC and gallbladder disease recently has been documented, although the role of bacteria remains controversial...
  58. ncbi Effects of NO/L-arginine pathway on gallbladder contractility in bile duct ligated guinea pigs
    Sinan Soylu
    Department of General Surgery, Cumhuriyet University School of Medicine, Sivas, Turkey
    J Surg Res 155:70-6. 2009
    Common bile duct ligation (CBDL) produces gallbladder distension and acute inflammation similar to that seen in human acute acalculous cholecystitis. CBDL in the guinea pig affects smooth muscle contractility...
  59. ncbi Expression of p53 upregulated modulator of apoptosis (PUMA) and C-myb in gallbladder adenocarcinoma and their pathological significance
    W Cai
    Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Number 139, Renmin Road, Changsha, 410011, Hunan, People s Republic of China
    Clin Transl Oncol 15:818-24. 2013
    ..However, few studies have examined gallbladder cancer specimens, and little is known about the clinical and pathological significance signaling changes may ..
  60. ncbi Laparoscopic cholecystectomy for acute cholecystitis. Can preoperative factors predict conversion?
    Iftikhar A Khan
    Division of General Surgery, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 25:299-302. 2004
    ..To determine if preoperative clinical, laboratory and radiology data can predict conversion of laparoscopic cholecystectomy for acute cholecystitis to open procedure...
  61. ncbi ABCG5 and ABCG8 are expressed in gallbladder epithelial cells
    Aimee Tauscher
    Division of Gastroenterology, University of Washington School of Medicine, Box 356424, 1959 NE Pacific St, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 307:1021-8. 2003
    b>Gallbladder epithelial cells (GBEC) are exposed to high biliary cholesterol concentrations on their apical (AP) surface. The mechanisms of cholesterol absorption and efflux by these cells are not known...
  62. ncbi Effect of timing of surgery, type of inflammation, and sex on outcome of laparoscopic cholecystectomy for acute cholecystitis
    Kamal I A Gharaibeh
    Department of General Surgery, Princess Basma Teaching Hospital, University of Science and Technology, Irbid, Jordan
    J Laparoendosc Adv Surg Tech A 12:193-8. 2002
    ..Our aim was to establish the outcome of LC in patients with AC on the basis of duration of the attack before surgery took place, the type of gallbladder inflammation, and patient sex.
  63. ncbi Bifid liver presenting with anomalous quadrate and caudate lobes and a transverse gallbladder
    A P Gesase
    Department of Anatomy Histology, Muhimbili University College of Health Sciences, P O BOX 65406 Dar es salaam, Tanzania
    Morphologie 90:160-3. 2006
    ..that included a vertically oriented porta hepatis, abnormal Y-shaped fissures on the right lobe, transverse gallbladder, absence of the caudate process on the caudate lobe, abnormal quadrate lobe, and transverse fissure on the ..
  64. ncbi Morphology and ultrastructure of Sphaeromyxa noblei sp. n. (Myxozoa), parasite of Heteroclinus whiteleggii (Pisces) from Australian New South Wales coast
    Jiri Lom
    Institute of Parasitology, Academy of Sciences of the Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    Folia Parasitol (Praha) 51:19-26. 2004
    ..Sections through polar capsule reveal different appearance of subsequent stretches of the polar filament unlike in other Myxosporea...
  65. ncbi Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma
    Xilin Du
    Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, 710038, Xi an, People s Republic of China
    Clin Transl Oncol 15:198-204. 2013
    ..However, its role in primary gallbladder carcinoma (PGC) is still unclear...
  66. ncbi Gallbladder wall thickening: MR imaging and pathologic correlation with emphasis on layered pattern
    S E Jung
    Department of Radiology, St Mary s Hospital, The Catholic University of Korea, 62, Yeouido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Eur Radiol 15:694-701. 2005
    The aim of this study was to correlate MR findings of gallbladder wall thickening with pathologic findings on the basis of the layered pattern and to evaluate the diagnostic value of MR imaging in gallbladder disease...
  67. ncbi Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder
    Jacob G Kirkland
    Department of Surgery, University of California San Francisco, CA 94121, USA
    Am J Physiol Gastrointest Liver Physiol 293:G335-46. 2007
    ..However, the distribution of PARs in the gallbladder is unknown, and their effects on gallbladder function have not been fully investigated...
  68. ncbi Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury
    Guo Zhong Tao
    Palo Alto VA Medical Center, Palo Alto, Mail code 154J, 3801 Miranda Avenue, Palo Alto, CA 94304 and Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA
    J Cell Sci 116:4629-38. 2003
    ..the liver from environmental insults, but little is known regarding keratins and their function in the gallbladder. We characterized keratin expression pattern and filament organization in normal and keratin polypeptide-8 (K8)-..
  69. pmc Isolation of Enterobacter intermedium from the gallbladder of a patient with cholecystitis
    C M O'Hara
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 36:3055-6. 1998
    We describe the isolation and identification of Enterobacter intermedium from the gallbladder of a patient with cholecystitis...
  70. ncbi Percutaneous cholecystolithotomy: a case for fulguration of the gallbladder wall
    Sero Andonian
    Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    J Laparoendosc Adv Surg Tech A 19:393-5. 2009
    ..However, it is associated with a high (41%) recurrence of cholelithiasis due to intact gallbladder mucosa...
  71. ncbi Diffuse gallbladder wall thickening: differential diagnosis
    Adriaan C van Breda Vriesman
    Department of Radiology, Rijnland Hospital, Simon Smitweg 1, PO Box 4220, NL 2350 CC Leiderdorp, The Netherlands
    AJR Am J Roentgenol 188:495-501. 2007
    The objective of our study was to review and illustrate the various clinical entities that may cause diffuse thickening of the gallbladder wall on diagnostic imaging studies.
  72. ncbi Consideration of anatomical structures relevant to the surgical strategy for managing gallbladder carcinoma
    Charles H C Pilgrim
    The Alfred Hospital, Upper Gastrointestinal Surgery, Commercial Rd, Melbourne, VIC 3000, Australia
    Eur J Surg Oncol 35:1131-6. 2009
    b>Gallbladder carcinoma usually presents late with advanced disease. It develops in an anatomically complex area. Consideration is given to resection of relevant local structures with respect to outcome.
  73. ncbi Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast-enhanced magnetic resonance cholangiography
    Laura M Fayad
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 18:449-60. 2003
    ..To determine the diagnostic performance of functional magnetic resonance cholangiography (fMRC) for the evaluation of anatomic and functional biliary disorders...
  74. ncbi Brush cells of rodent gallbladder and stomach epithelia express neurofilaments
    Liliana Luciano
    Department of Cell Biology, Center of Anatomy, Hannover Medical School, Hannover, Germany
    J Histochem Cytochem 51:187-98. 2003
    ..b>Gallbladder and stomach specimens from mice and rats, respectively, were fixed in various solutions, embedded either in ..
  75. ncbi Microbiology of gallbladder bile in uncomplicated symptomatic cholelithiasis
    Vasitha Abeysuriya
    Department of Clinical Anatomy, Faculty of Medicine, Ragama, Sri Lanka
    Hepatobiliary Pancreat Dis Int 7:633-7. 2008
    ..Few studies have assessed microflora and their antibiotic sensitivity in normal bile and lithogenic bile with different types of gallstones...
  76. ncbi Real-time sonography for screening of gallbladder dysfunction in children with type 1 diabetes mellitus
    I Arslanoglu
    Department of Pediatrics, Göztepe Educational Hospital of SSK, Turkey
    J Pediatr Endocrinol Metab 14:61-9. 2001
    The aim of this study was to evaluate the occurrence of gallbladder dysfunction in children with type 1 diabetes mellitus using real-time ultrasonography. The study population consisted of 20 diabetic children (11 male, 9 female; age 11...
  77. ncbi Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
    Gastroenterology 131:210-22. 2006
    The gel-forming mucins play an important role in the early stage of cholesterol gallstone formation. We investigated whether the gallbladder epithelial mucin encoded by mucin gene 1 (MUC1) influences susceptibility to gallstones.
  78. ncbi [Incidentalomas of the liver and gallbladder. Evaluation and therapeutic procedure]
    Carl Zülke
    Chirurgische Klinik und Poliklinik, Universitatsklinikum Regensburg
    Chirurg 78:698-712. 2007
    ..The stage-oriented radical re-resection following diagnosis of an incidentally detected gallbladder cancer may lead to significantly improved long-term survival, especially in the early tumour stages T1b and T2, ..
  79. ncbi Profile of gallbladder diseases diagnosed at Afyon Kocatepe University: a retrospective study
    Mustafa Mazlum
    Department of Pathology, Afyon Kocatepe University, Faculty of Medicine, Afyonkarahisar, Turkey
    Turk Patoloji Derg 27:23-30. 2011
    b>Gallbladder is one of the most commonly encountered specimen in a pathology laboratory. A diverse spectrum of diseases affect the biliary system, often presenting with similar clinical signs and symptoms...
  80. ncbi Abnormalities of the gallbladder, clinical effects
    J P Faure
    Service Chirurgie Viscérale Digestive et Endocrinienne, Hopital Jean Bernard, CHU Poitiers, Universite de Poitiers, 2 rue de la Miletrie, BP 577, 86021 Poitiers Cedex, France
    Surg Radiol Anat 30:285-90. 2008
    ..literature was to present and discuss the anatomical and embryological basis of congenital abnormalities of the gallbladder, based on a case of volvulus...
  81. ncbi Transient reticular gallbladder wall thickening in severe dengue fever: a reliable sign of plasma leakage
    Gabriel Antonio Oliveira
    Nossa Senhora da Gloria Children s Hospital, Rua Mary Ubirajara 205, Vitoria, Brazil
    Pediatr Radiol 40:720-4. 2010
    ..The main feature of this severe form of DF is plasma leakage. Gallbladder wall thickening (GBWT), ascites and pleural effusion represent the sonographic triad of plasma leakage in DF.
  82. ncbi Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor?
    Alberto E Paniz Mondolfi
    Department of Pathology and Laboratory Medicine, St Luke s Roosevelt Hospital Center, St Luke s Division, Clark 4, 1111 Tenth Avenue, New York, NY 10025, USA
    Pathol Int 61:608-14. 2011
    ..A PET-CT of the abdomen and pelvis demonstrated hypermetabolic, polypoid masses within the gallbladder and several tumors in the left lobe of the liver for which she underwent diagnostic laparoscopy...
  83. pmc An unusual cause of cholecystitis: heterotopic pancreatic tissue in the gallbladder
    Gulsum Ozlem Elpek
    Akdeniz University, Medical School, Department of Pathology, Yeni Tip, Dekanlik, 07070, Antalya, Turkey
    World J Gastroenterol 13:313-5. 2007
    b>Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis...
  84. ncbi Contrast enhanced sonography of the gallbladder: a tool in the diagnosis of cholecystitis?
    Boris Adamietz
    Institute of Radiology, University of Erlangen, Maximiliansplatz 1, 91054 Erlangen, Germany
    Eur J Radiol 61:262-6. 2007
    To evaluate if contrast enhanced sonography (CES) can help to detect gallbladder inflammation and differentiate between acute and chronic cholecystitis.
  85. ncbi Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium
    Sylvia Aust
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Lab Invest 84:1024-36. 2004
    Epithelium of the gallbladder and biliary tract is exposed to high concentrations of potentially harmful exogenous and endogenous compounds excreted into primary bile...
  86. ncbi Accurate staging for gallbladder cancer: implications for surgical therapy and pathological assessment
    Hiromichi Ito
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 254:320-5. 2011
    This study evaluates the significance of tumor involvement of the liver in early T-stage tumors and lymph node (LN) metastases on outcome after R0 resection of gallbladder cancer (GBCA).
  87. doi [Right liver agenesis with ectopic gallbladder and bile duct calculi]
    R Boufettal
    Gastroenterol Clin Biol 32:405-7. 2008
  88. ncbi Gallbladder bed irrigation with bupivacaine improves pulmonary functions after laparoscopic cholecystectomy
    Hunsu Alptekin
    Department of Surgery, Selcuklu Medical Faculty, Selcuk University, 42075, Konya, Turkey
    Langenbecks Arch Surg 395:501-4. 2010
    Afferent stimulus arising from gallbladder and its bed may elicit reflex inhibition of the diaphragm. Pulmonary function would be improved by blocking this stimulus after laparoscopic cholecystectomy...
  89. ncbi Abnormal peritoneal fold connecting the greater omentum with the liver, gallbladder, right kidney and lesser omentum
    Satheesha B Nayak
    Melaka Manipal Medical College Manipal Campus, International Centre for Health Sciences, Madhav Nagar, Manipal, Udupi District, Karnataka State, India
    Bratisl Lek Listy 110:736-7. 2009
    ..fold of peritoneum that extended from the upper right part of the greater omentum and stomach to the fossa for gallbladder. This fold merged with the lesser omentum on the left and extended to the right kidney when traced posteriorly...
  90. ncbi Gallbladder stent placement for prevention of cholecystitis in patients receiving covered metal stent for malignant obstructive jaundice: a feasibility study
    Sonia Gosain
    Digestive Health Center, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Dig Dis Sci 55:2406-11. 2010
    ..Occlusion of the cystic duct by CSEMS may be complicated by cholecystitis. This potentially could be prevented by placement of a transpapillary gallbladder stent (GBS).
  91. ncbi Gallbladder wall thickening in mononucleosis syndromes
    K Yamada
    Department of General Internal Medicine, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Hamamatsu 430-8558, Japan
    J Clin Ultrasound 29:322-5. 2001
    PURPOSE: We used sonography to measure gallbladder wall thickness in patients with mononucleosis syndromes and then evaluated laboratory data, spleen size, and clinical evolution to assess any relationship between gallbladder wall ..
  92. ncbi Design and application of a new series of gallbladder endoscopes that facilitate gallstone removal without gallbladder excision
    Tie Qiao
    The Second People s Hospital of Panyu District, Panyu, Guangzhou, People s Republic of China
    Rev Sci Instrum 83:015115. 2012
    In recent years, some Chinese doctors have proposed a new concept, gallstone removal without gallbladder excision, along with transition of the medical model...
  93. ncbi Cholecystitis, gallstones and free radical reactions in human gallbladder
    P Sipos
    2nd Department of Surgery, Semmelweis University, Budapest, Kútvölgyi u 4, H 1125 Hungary
    Med Sci Monit 7:84-8. 2001
    The relationship between biophysical and biochemical processes of gallbladder bile and free radical reactions is still not known...
  94. ncbi Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder
    Bridget C Lynch
    Department of Pathology, University of New Mexico School of Medicine, MSC 084640 Albuquerque, NM 87131 0001, USA
    Ann Diagn Pathol 12:161-4. 2008
    The sequence of molecular changes leading to neoplastic transformation in the gallbladder remains elusive...
  95. ncbi Biliary-hepatic recycling of a xenobiotic: gallbladder absorption of methyl mercury
    W J Dutczak
    Department of Biophysics, University of Rochester School of Medicine, New York 14642
    Am J Physiol 260:G873-80. 1991
    The role of the gallbladder in the disposition of methyl mercury was investigated in guinea pig, hamster, and macaque monkey...
  96. pmc Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis
    C Maesawa
    Department of Pathology, Iwate Medical University School of Medicine, Uchimaru 19 1, 020 8505 Morioka, Japan
    J Clin Pathol 59:328-30. 2006
    ..expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed in gallbladder carcinomas, whereas the non-tumorous gallbladder epithelium is maspin negative...
  97. ncbi Agenesis of the gallbladder with hypoplastic cystic duct diagnosed at laparoscopy
    A Hon Kwon
    Department of Surgery, Kansai Medical University, Osaka, Japan
    Surg Laparosc Endosc Percutan Tech 16:251-4. 2006
    ..Ultrasonography of the abdomen showed dilated extrahepatic bile ducts containing stones; however, the gallbladder was not clearly identified...
  98. ncbi Identification of PEG10 and TSG101 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
    Dong Cai Liu
    Department of Geriatric Surgery, Central South University, Changsha, Hunan 410011, China
    Pathol Oncol Res 17:859-66. 2011
    ..However, their expression and clinical significance in gallbladder cancer (GBC) have not yet been identified...
  99. ncbi Diagnostic imaging of carcinomas of the gallbladder and the bile ducts
    H Oikarinen
    Department of Diagnostic Radiology, Oulu University Hospital, OYS, Finland
    Acta Radiol 47:345-58. 2006
    Early diagnosis and accurate staging of carcinomas of the gallbladder and the bile ducts are helpful in improving the prognosis...
  100. ncbi Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obestity
    Bilal O Al-Jiffry
    Departmentof General and Digestive Surgery, Flinders University of South Australia, Adelaide, Australia
    Can J Gastroenterol 17:169-74. 2003
    ..Morbid obesity is associated with cholesterol gallstone formation, a risk compounded by rapid weight loss. Laparoscopic gastric banding allows for a measured rate of weight loss, but the subsequent risk for developing gallstones is unknown...
  101. ncbi Hepatic artery pseudoaneurysm associated with cholecystitis that ruptured into the gallbladder
    Tomotaka Akatsu
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol 39:900-3. 2004
    ..Color-Doppler ultrasound imaging showed a pulsatile wave pattern in an echogenic lesion inside the gallbladder. Contrast-enhanced computed tomography demonstrated a 3-cm pseudoaneurysm in the distended gallbladder...

Research Grants63

  1. A Microfluidic-platform Mini-Liver System for Human Liver Biology Studies
    HONGSEOK M NOH; Fiscal Year: 2010
    ..The hepatic portal vein carries blood from the intestines, pancreas, spleen and gallbladder and exposes the liver to nutrients and toxins derived from these sources...
  2. Early Pathogenesis of Cystic Fibrosis Related Diabetes
    Andrew W Norris; Fiscal Year: 2013
    ..CF is a multi-organ disease affecting the lung, pancreas, liver, intestine, and gallbladder. Cystic fibrosis related diabetes (CFRD) is the most common significant complication of CF and is well known to ..
  3. Extracellular Replication of Listeria in Vivo
    Christopher H Contag; Fiscal Year: 2010
    ..We have recently identified the gallbladder as a potential reservoir of bacteria in symptomatic and asymptomatic infected mice, and have determined that ..
  4. Regulation of Metabolism by the Hormone FGF15/19
    Steven A Kliewer; Fiscal Year: 2013
    ..In turn, FGF15/19 enters the hepatic portal circulation and governs bile acid synthesis and gallbladder filling...
  5. Genetic determinants of total cholesterol levels in American Indians
    JOHANNA K DISTEFANO; Fiscal Year: 2013
    ..observed linkage for TC concentration, and 740 Mexican American individuals from the San Antonio Family Gallbladder Disease Study (SAFGS), who are more likely to share greater genetic similarity with Pima Indians...
  6. Exploring the Attitudes and Use of Family Cancer History and Biospecimen Collecti
    JANET JEANNE KELLY; Fiscal Year: 2013
    ..are significantly higher among AN people compared to US Whites for lung, colorectal, stomach, kidney, liver, gallbladder, pancreas, esophagus and oral/pharyngeal cancers...
  7. Isolation, Identification and Characterization of a Toxin Causing Biliary Atresia
    Rebecca G Wells; Fiscal Year: 2013
    ..fractions with a complexity of 2-20 that, remarkably, cause a BA-like pattern of injury (with atresia of the gallbladder and extrahepatic biliary tree) in zebrafish larvae exposed after biliary morphogenesis has occurred, mimicking ..
  8. STAT1 Activation and HPP1 Tumor Suppression
    David Shibata; Fiscal Year: 2013
    ..has subsequently been found to occur in tumors of the colon and rectum, stomach, small bowel, pancreas, gallbladder, prostate and lung...
  9. Receptor Regulation of CCK Cell Function
    Rodger A Liddle; Fiscal Year: 2013
    ..Specifically CCK regulates gallbladder contraction, pancreatic enzyme secretion, delays gastric emptying, and induces satiety...
  10. Identification of Prediabetes Genes by Expression Linkage Analysis
    Christopher P Jenkinson; Fiscal Year: 2013
    ..studies, the Veterans Administration Genetic Epidemiology Study (VAGES) and the San Antonio Family Diabetes/Gallbladder Disease Study (SAFDGS)...
  11. Mechanisms Regulating Gastrointestinal Hormone Secretion
    Rodger A Liddle; Fiscal Year: 2013
    ..Cholecystokinin (CCK) is a prototypical gastrointestinal hormone that regulates gallbladder contraction, pancreatic enzyme secretion, delays gastric emptying, and induces satiety...
  12. Epidemiology of Ultrasound-Defined NAFLD in the General U.S. Population
    Jeanne M Clark; Fiscal Year: 2010
    ..Specifically, NHANES III included standardized gallbladder ultrasounds which can be reread to detect hepatic steatosis and the findings linked to all NHANES III data...
  13. NEURAL CONTROL OF THE GALLBLADDER
    Gary M Mawe; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Decreased contractility is a hallmark of gallbladder disorders, and it is associated with inflammation and gallstone formation...
  14. Molecular Mechanisms of Intrahepatic Cholestasis
    Benjamin L Shneider; Fiscal Year: 2013
    ..influenced by FIC1, 2) Analysis of the molecular mechanisms of FIC1 disease, 3) Examination of FXR signaling in gallbladder in human cholestasis...
  15. Type A CCK Receptor Structure, Function &Regulation
    Laurence J Miller; Fiscal Year: 2013
    ..functions supporting nutritional homeostasis, including the stimulation of pancreatic exocrine secretion and gallbladder emptying, the regulation of gastric emptying and bowel transit, and the modification of appetite...
  16. Regulation of the ABCG5 ABCG8 Sterol Transporter
    Gregory A Graf; Fiscal Year: 2012
    ..Obesity and diabetes (diabesity) are associated with increased risk of cardiovascular and gallbladder disease, elevated plasma cholesterol levels, and a predilection for cholesterol synthesis rather than ..
  17. Type A CCK Receptor Structure Function and Regulation
    Laurence J Miller; Fiscal Year: 2010
    ..CCK is important for nutrient assimilation, with roles in regulating post-cibal pancreatic secretion, gallbladder emptying, gut transit, and satiety...
  18. The role of T-cells and Th 1 immunity in cholesterol gallstones
    KIRK JAMES MAURER; Fiscal Year: 2011
    ..In general, these stones form in the gallbladder when bile is supersaturated with cholesterol...
  19. SURGICAL STUDIES ON METABOLISM OF G. I. HORMONES
    James Thompson; Fiscal Year: 1993
    ..We plan to study the mechanisms of actions of CCK on gallbladder (GB) smooth muscle...
  20. PHYSICAL CHEMISTRY OF BILIRUBIN & ITS CONJUGATES
    WILLIAM SPIVAK; Fiscal Year: 1990
    ..We prostulated that continuous non-enzymatic alkaline hydrolysis of BMG to UCB within the gallbladder (or within the bile ductules in cholestasis) may be the major source of precipitated UCB and its derivatives, ..
  21. Improved Surgical Treatment of Pelvic Organ Prolapse
    KEITH LIPFORD; Fiscal Year: 2009
    ..into one that is done primarily laparoscopically, similar to what occurred with cholecystectomy (removal of the gallbladder)...
  22. UNIVERSITY OF NEW MEXICO CANCER CENTER PLANNING GRANT
    Cheryl Willman; Fiscal Year: 2004
    ..types of cancer that are common in non-Hispanic Whites, both Indians and Hispanics have had very high rates of gallbladder, stomach, and cervix cancer in the past several decades...
  23. Fibroblast Growth Factor Regulation in the Pancreas
    Sam Holmstrom; Fiscal Year: 2009
    ..Our recent studies show that fibroblast growth factor 15 (FGF15) is a secreted endocrine hormone that promotes gallbladder filling and opposes CCK-induced contraction of the gallbladder (9)...
  24. MYOGENIC DISORDERS OF THE GALLBLADDER
    Jose Behar; Fiscal Year: 2004
    Acute cholecystitis (AC) affects 88% of patients with symptomatic gallbladder (GB) stones over a 18 year period and has a significant morbidity and mortality in elderly patients...
  25. BIOSYNTHESIS OF GASTROINTESTINAL HORMONES
    Andrew Leiter; Fiscal Year: 1990
    ..polypeptide, produced in the pancreatic islets, inhibits pancreatic exocrine secretion and relaxes the gallbladder. Peptide YY, which is made in endocrine cells of the colon and ileum, also inhibits pancreatic exocrine ..
  26. Function and Regulatin of Intestinal Basolateral Organic Solute Transporters
    Anuradha Rao; Fiscal Year: 2009
    Project Summary: Bile acids are secreted by the liver, stored in the gallbladder, and efficiently reabsorbed from the intestine...
  27. ROLE OF THE GALLBLADDER IN PATHOGENESIS OF GALLSTONES
    LESTER WILLIAMS; Fiscal Year: 1991
    ..Patients with GS or pregnancy and animals with GA have gallbladder (GB stasis...
  28. DYNAMICS OF RETINOPATHY AMONG MEXICAN AMERICAN DIABETICS
    Craig Hanis; Fiscal Year: 1990
    ..diabetics will be added to this group through random sampling in Starr County during ongoing investigations of gallbladder disease...
  29. NEURAL CONTROL OF THE GALLBLADDER
    Gary Mawe; Fiscal Year: 1992
    A great deal of morbidity is caused by diseases of the gallbladder; nevertheless, the control of the motile and absorptive functions of the organ are incompletely understood...
  30. CELLULAR MECHANISMS OF CHOLECYSTITIS AND COLITIS
    DONALD KAMINSKI; Fiscal Year: 1999
    ..Previous studies have demonstrated that cyclooxygenase inhibitors are specific drugs for the treatment of gallbladder disease...
  31. OCCUPATIONAL MORTALITY--CALIFORNIA HISPANIC POPULATION
    James Beaumont; Fiscal Year: 1993
    ..For example, tumors of the gallbladder, stomach, cervix, and liver occur excessively in the Hispanic population of the U.S...
  32. ROLE OF CALCIUM AND CAFFEINE IN GALLSTONE DISEASE
    Keith Lillemoe; Fiscal Year: 1993
    ..flow rates and should define for the first time in this model the kinetics of calcium secretion; 2) Gallbladder glycoprotein secretion...
  33. ION TRANSPORT IN SMALL INTESTINE
    William Armstrong; Fiscal Year: 1991
    ..stability in vitro and their functional resemblance to their mammalian analogs, isolated Necturus intestine and gallbladder are used...
  34. CHLORIDE CHANNELS IN A MODEL EPITHELIUM--GALLBLADDER
    ARTHUR FINN; Fiscal Year: 1991
    ..We have chosen the amphibian gallbladder as the model since its absorptive function is similar in many respects to that of the small intestine, and ..
  35. FEEDBACK REGULATIION OF PANCREATIC ENZYME SECRETION
    Chung Owyang; Fiscal Year: 2000
    DESCRIPTION: Cholecystokinin plays a major role in the mediation of pancreatic secretion and gallbladder contraction after a meal, however little is known about the mechanisms regulating its secretion...
  36. SPHINCTER OF ODDI FUNCTION IN HEALTH AND DISEASE
    Walter Hogan; Fiscal Year: 1990
    ..duct systems in humans and experimental animals, and 2) abnormalities of sphincter of Oddi (SO) and gallbladder function in humans...
  37. SURGICAL STUDIES ON GALLBLADDER INFLAMMATION
    Stuart Myers; Fiscal Year: 1992
    Acute inflammation of the gallbladder (cholecystitis) is a serious disease which can cause substantial morbidity and death...
  38. Role of Gallbladder Ion Transport in Gallstone Formation
    A Moser; Fiscal Year: 2006
    ..His career development plan includes both didactic and practical studies of gallbladder ion transport with the supervision of two highly successful and innovative scientists at the University of ..
  39. Long Chain Fatty Acid (LCFA) Taste Receptor CD36 in Food Choice and Consumption
    Eric Walters; Fiscal Year: 2007
    ..a number of medical conditions, including obesity, diabetes, cardiovascular disease, hypertension, cancer, and gallbladder disease...
  40. DNA DAMAGE INDUCED BY PANCREATROPIC NITROSAMINES
    Demetrius Kokkinakis; Fiscal Year: 1990
    ..BHP), and N-Nitroso(2-hydroxypropyl) (2-oxopropyl) amine (HPOP) induce tumors of the pancreas, lungs, gallbladder, kidneys and bladder in hamsters and upper respiratory tract, esophagus, liver, and kidney tumors in rats...
  41. Novel therapies for biliary cancers in BK5.erbB-2 mice
    John DiGiovanni; Fiscal Year: 2007
    ..expression of rat erbB2 in the biliary tract epithelium leads to development of papillary adenocarcinoma of the gallbladder. Current chemotherapeutic strategies for treating human biliary tract cancers include nucleoside analogs such ..
  42. SUB-MICRON X-RAY TOMOGRAPHY OF CALCIFIED TISSUE
    Michael Flynn; Fiscal Year: 1999
    ..e., such as benign or malignant calcifications of the breast, vascular plaque, stones formed in the kidney or gallbladder, etc.)...
  43. MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESIS
    Gwynneth Offner; Fiscal Year: 2000
    The overall goal of this project is to understand the role of gallbladder mucin in the pathogenesis of cholesterol gallstones...
  44. In vivo biosensor screen for mutants in lipid metabolism
    Steven Farber; Fiscal Year: 2005
    ..Fluorescent lipids ingested by day 5 post-fertilization zebrafish larvae produce intense gallbladder fluorescence, a finding we have shown reflects lipid processing by intestinal PLA2 and subsequent transport ..
  45. Gender Differences in Gallstone Pathogenesis
    MOHAMMAD ABEDIN; Fiscal Year: 2006
    ..Female sex hormones promote gallstone formation by increasing biliary cholesterol saturation and gallbladder motility...
  46. SALT TRANSPORT MECHANISMS IN GALLBLADDER EPITHELIUM
    Luis Reuss; Fiscal Year: 1999
    ..project are to identify the Cl- channels in the apical and basolateral membranes of the epithelial cells of the gallbladder of Necturus maculosus and to determine the mechanisms underlying their physiological regulation and ..
  47. MUCIN AND TREFOIL PROTEINS IN GALLSTONE PATHOGENESIS
    David Nunes; Fiscal Year: 1999
    The goal of this study is to study the function and functional relationship of two important gallbladder mucosal proteins, mucin and trefoil proteins in cholesterol nucleation and gallstone pathogenesis...
  48. OBESITY, LEPTIN AND GALLSTONE PATHOGENESIS
    Henry Pitt; Fiscal Year: 2005
    ..mice suggest that they have alterations in biliary lipids, enhanced cholesterol crystal formation and increased gallbladder volume. Leptin receptors also have been demonstrated in the liver and biliary tree of both mice and humans...
  49. EVALUATION OF CLINICAL OUTCOMES IN SMALL AREAS OF MICH
    LAURENCE MC MAHON; Fiscal Year: 1991
    ..we expect there to be differences in the problems/questions/interventions/solutions between the treatment of gallbladder disease with its largely impatient focus, and the screening and treatment of cancer of the colon with its ..
  50. NEURAL CONTROL OF THE GALLBLADDER
    Gary Mawe; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): A hallmark of biliary tract disease is a decrease in the tone of gallbladder smooth muscle (GBSM), and a decrease in the responsiveness of GBSM to excitatory agonists...
  51. GALLBLADDER MUCOSAL ABLATION BY PHOTODYNAMIC THERAPY
    Robert Hall; Fiscal Year: 2000
    ..propose an endoluminal operation using three technical innovations: 1) a cannula that attaches to the gallbladder surface, 2) a rapid rotary lithotriptor, and 3) a self-expanding cystic duct plug...
  52. EPIDEMIOLOGY OF GALLBLADDER SLUDGE & STONES IN PREGNANCY
    Cynthia Ko; Fiscal Year: 2006
    ..In order to disentangle the effects of physical activity, leptin and gestational diabetes on gallbladder disease risk, and to understand the mechanisms behind the observed associations, we propose to conduct a ..
  53. MECHANISMS OF HEPATOBILIARY TRANSPORT OF MERCURY
    Thomas Clarkson; Fiscal Year: 1991
    ..and metabolism, c) transport into bile, and d) postsecretory modifications within the biliary tree and in the gallbladder. The specific objectives of the proposed studies are to characterize these processes at the cellular and ..
  54. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..b>Gallbladder mucin plays a central role in gallstone formation and this proposal will examine the mechanism by which mucin ..
  55. Mechanistic Role of Peroxynitrite in Gallbladder Disease
    JOSEPH CULLEN; Fiscal Year: 2004
    ..Superoxide (O2-) rapidly oxidizes nitric oxide in the gallbladder to form peroxynitrite (ONOO-), which in turn can be protonated to form cytotoxic radicals...
  56. ASSESSING DIET CANCER ASSOCIATION IN NATIVE AMERICANS
    NICOLETTE TEUFEL SHONE; Fiscal Year: 1999
    ..problem for this minority population; incidence and age-adjusted mortality rates of cervical, stomach and gallbladder cancer among Native Americans are two to twenty times higher than that reported for US all races...
  57. Genetic Loci Influencing Human Gallbladder Disease
    Attila Nakeeb; Fiscal Year: 2006
    ..Mentored Patient-Oriented Research Career Development Award (K-23) to study the genetic loci influencing human gallbladder disease...
  58. GENETIC AND EPIDEMIOLOGIC APPROACHES TO CHRONIC DISEASES
    Craig Hanis; Fiscal Year: 1991
    ..In particular, the aims relate to diabetes and gallbladder disease among Mexican Americans of South Texas where these diseases are known to be elevated several-fold over ..
  59. ASSESSMENT OF CLINICAL UTILITY: THE OCG AND UGI
    KEITH MARTON; Fiscal Year: 1980
    ..important ways: a) We will prospectively measure the clinical utility of the oral cholecystogram (OCG) and the gallbladder ultrasound in clinical practice and use data from this study to develop decision rules based on the history and ..
  60. SECOND MESSENGERS, GALLBLADDER ABSORPTION AND GALLSTONES
    MOHAMMAD ABEDIN; Fiscal Year: 2001
    ..The proposed research is directed at determining the mechanisms by which supersaturated bile increase gallbladder absorption...
  61. A Device for Physical Activity and Energy Expenditure
    Ming Sun; Fiscal Year: 2004
    ..the risk of morbidity from hypertension; dyslipidemia; type 2 diabetes; coronary heart disease; stroke; gallbladder disease; osteoarthritis; sleep apnea and respiratory problems; and endometrial, breast, prostate, and colon ..
  62. Changing Cafeteria Portion Sizes to Prevent Weight Gain
    Stella Volpe; Fiscal Year: 2004
    ..Obesity has been related to many chronic diseases, such as diabetes mellitus, gallbladder disease, and some cancers...
  63. FUNCTION OF GUT/BRAIN PEPTIDES IN THE MOUSE
    LINDA SAMUELSON; Fiscal Year: 2000
    ..in diverse biological functions ranging from post-prandial control of pancreatic enzyme secretion and gallbladder contraction to the modulation of centrally controlled behaviors such as feeding and anxiety...