biliary tract

Summary

Summary: The BILE DUCTS and the GALLBLADDER.

Top Publications

  1. ncbi Oxidative stress: a radical way to stop making bile
    Marcelo G Roma
    Instituto de Fisiología Experimental Facultad de Ciencias Bioquímicas y Farmacéuticas CONICET U N R, S2002LRL, Rosario, Argentina
    Ann Hepatol 7:16-33. 2008
  2. pmc MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    J Immunol 183:1617-24. 2009
  3. pmc Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment
    Satoshi Kondo
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Hepatobiliary Pancreat Surg 15:41-54. 2008
  4. ncbi Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gastroenterology 128:1023-33. 2005
  5. ncbi Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt
    C Funk
    F Hoffmann La Roche Ltd, Non Clinical Development Drug Safety, PRNS 69 152, 4070 Basel, Switzerland
    Toxicology 167:83-98. 2001
  6. ncbi Organogenesis and development of the liver
    Karim Si-Tayeb
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Dev Cell 18:175-89. 2010
  7. pmc Hedgehog signaling in cholangiocytes
    Alessia Omenetti
    Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Gastroenterol 27:268-75. 2011
  8. ncbi Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis
    Luis A Marcos
    Institute of Tropical Medicine Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Curr Opin Infect Dis 21:523-30. 2008
  9. ncbi Effects of Helicobacter pylori γ-glutamyltranspeptidase on apoptosis and inflammation in human biliary cells
    Wongwarut Boonyanugomol
    Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Dig Dis Sci 57:2615-24. 2012
  10. ncbi Biliary tract injury caused by different relative warm ischemia time in liver transplantation in rats
    Hong Feng Zhao
    Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Hepatobiliary Pancreat Dis Int 8:247-54. 2009

Detail Information

Publications246 found, 100 shown here

  1. ncbi Oxidative stress: a radical way to stop making bile
    Marcelo G Roma
    Instituto de Fisiología Experimental Facultad de Ciencias Bioquímicas y Farmacéuticas CONICET U N R, S2002LRL, Rosario, Argentina
    Ann Hepatol 7:16-33. 2008
    ....
  2. pmc MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    J Immunol 183:1617-24. 2009
    ..parvum infection. Our data suggest that miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response...
  3. pmc Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment
    Satoshi Kondo
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Hepatobiliary Pancreat Surg 15:41-54. 2008
    The only curative treatment in biliary tract cancer is surgical treatment. Therefore, the suitability of curative resection should be investigated in the first place...
  4. ncbi Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation
    Kirk J Maurer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gastroenterology 128:1023-33. 2005
    ..To test this, we prospectively investigated the effects of Helicobacter spp infection in cholesterol gallstone pathogenesis in the highly susceptible C57L/J mouse model...
  5. ncbi Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt
    C Funk
    F Hoffmann La Roche Ltd, Non Clinical Development Drug Safety, PRNS 69 152, 4070 Basel, Switzerland
    Toxicology 167:83-98. 2001
    ..Such an interaction might lead potentially also in man to a troglitazone-induced intrahepatic cholestasis, potentially contributing to the formation of troglitazone-induced liver injuries...
  6. ncbi Organogenesis and development of the liver
    Karim Si-Tayeb
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Dev Cell 18:175-89. 2010
    ..Here, we review the basic molecular mechanisms that control the formation of the liver as an organ...
  7. pmc Hedgehog signaling in cholangiocytes
    Alessia Omenetti
    Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Gastroenterol 27:268-75. 2011
    ..Because this has potential implications for liver repair, this review will summarize current knowledge about Hh signaling and cholangiocytes...
  8. ncbi Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis
    Luis A Marcos
    Institute of Tropical Medicine Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Curr Opin Infect Dis 21:523-30. 2008
    ..The present review focuses on current knowledge of clinical, diagnostic and treatment aspects caused by hepatobiliary flukes that can be applied to current protocols in endemic areas...
  9. ncbi Effects of Helicobacter pylori γ-glutamyltranspeptidase on apoptosis and inflammation in human biliary cells
    Wongwarut Boonyanugomol
    Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Dig Dis Sci 57:2615-24. 2012
    ..Here, we determined the effects of H. pylori γ-glutamyltranspeptidase (GGT) on the induction of apoptosis and IL-8 production in a human cholangiocarcinoma cell line (KKU-100 cells)...
  10. ncbi Biliary tract injury caused by different relative warm ischemia time in liver transplantation in rats
    Hong Feng Zhao
    Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Hepatobiliary Pancreat Dis Int 8:247-54. 2009
    ..This study was undertaken to assess biliary tract injury caused by relative warm ischemia (secondary warm ischemia time in the biliary tract) and reperfusion.
  11. pmc Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    Nucleic Acids Res 38:3222-32. 2010
    ..Thus, a subset of miRNA genes is regulated in human biliary epithelial cells through NF-kappaB activation induced by LPS, suggesting a role of the NF-kappaB pathway in the transcriptional regulation of miRNA genes...
  12. ncbi A novel approach to biliary tract pathology based on similarities to pancreatic counterparts: is the biliary tract an incomplete pancreas?
    Yasuni Nakanuma
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Pathol Int 60:419-29. 2010
    There are peribiliary glands around the biliary tract, and these glands drain into the bile duct lumen. Interestingly, small amounts of pancreatic exocrine acini are intermingled with these glands...
  13. ncbi Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs
    Yoshihisa Shitara
    School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo 142 8555, Japan
    Annu Rev Pharmacol Toxicol 45:689-723. 2005
    ..To avoid adverse consequences of such transporter-mediated drug-drug interactions, we need to be more aware of the role played by drug transporters as well as those caused by drug metabolizing enzymes...
  14. pmc Biliary lipids and cholesterol gallstone disease
    David Q H Wang
    Department of Medicine, Harvard Medical School, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, and Harvard Digestive Diseases Center, and Brigham and Women s Hospital, Boston, MA 02115, USA
    J Lipid Res 50:S406-11. 2009
    ....
  15. ncbi Role of cagA-positive Helicobacter pylori on cell proliferation, apoptosis, and inflammation in biliary cells
    Wongwarut Boonyanugomol
    Department of Microbiology, and Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Dig Dis Sci 56:1682-92. 2011
    ..We compared the effects of H. pylori cagA(+) and cagA(-) mutant strains on cell proliferation, apoptosis, and inflammation in a cholangiocarcinoma (CCA) cell line (KKU-100)...
  16. ncbi K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers
    T Itoi
    Fourth Department of Internal Medicine, Tokyo Medical College, Japan
    Pathol Int 49:30-7. 1999
    ..To evaluate whether it is useful for diagnosis to detect K-ras and p53 mutations in biopsy specimens and bile of biliary tract lesions, 12 cholangiocarcinomas (CC), eight cases of cholangitis, seven gallbladder carcinomas (GBC), seven ..
  17. ncbi Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent
    Jin Young Choi
    Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Republic of Korea
    J Magn Reson Imaging 31:571-8. 2010
    ..To assess the diagnostic performance of gadobenate dimeglumine-enhanced 3D gradient echo (3D-GRE) magnetic resonance imaging (MRI) for the detection of hepatic hypovascular metastases...
  18. ncbi Expression of NF-kappaB in rotavirus-induced damage to the liver and biliary tract in neonatal mice
    Lei Huang
    Department of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
    Hepatobiliary Pancreat Dis Int 6:188-93. 2007
    ..In this study, we aimed to investigate the histopathological patterns of different kinds of rotavirus in the liver and biliary tract of neonatal mice and the expression of NF-kappaB in the liver and biliary tract of infected mice.
  19. ncbi PTEN loss and KRAS activation cooperate in murine biliary tract malignancies
    Victoria Marsh
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    J Pathol 230:165-73. 2013
    Carcinomas of the biliary tract are aggressive malignancies in humans. Loss of the tumour suppressor PTEN has previously been associated with cholangiocarcinoma development in a murine model...
  20. ncbi Motility and dysmotility of the biliary tract
    Krishnavel V Chathadi
    Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0362, USA
    Semin Gastrointest Dis 14:199-207. 2003
    ..However, patients with suspected SOD have the highest complication rate from endoscopic retrograde cholangiogram and sphincterotomy, and, therefore, careful patient selection is mandatory...
  21. pmc Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies
    K Tominaga
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Gut 53:1167-73. 2004
    ..Systemic adenoviral readministration appears to be limited by immunogenicity...
  22. ncbi DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union
    Takashi Shimotake
    Division of Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Pediatr Surg 38:694-7. 2003
    ..studies have found that anomalous pancreaticobiliary ductal union (APBDU) is a substantial risk factor for biliary tract cancer at a younger age...
  23. pmc CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow
    Stuart M Curbishley
    Liver Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, The University of Birmingham Medical School, Edgbaston, Birmingham, UK B15 2TT
    Am J Pathol 167:887-99. 2005
    ....
  24. ncbi Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas
    J Hedstrom
    Department of Clinical Chemistry, University of Helsinki, Finland
    Scand J Clin Lab Invest 61:111-8. 2001
    ..of trypsinogen-1, -2 and tumour-associated trypsin-inhibitor (TATI) were determined in 23 patients with benign biliary tract disease, two with biliary tract cancer, and in 15 with pancreatic cancer...
  25. pmc Gallstones and the risk of biliary tract cancer: a population-based study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Br J Cancer 97:1577-82. 2007
    We conducted a population-based study of 627 patients with biliary tract cancers (368 of gallbladder, 191 bile duct, and 68 ampulla of Vater), 1037 with biliary stones, and 959 healthy controls randomly selected from the Shanghai ..
  26. ncbi The onecut transcription factor HNF6 is required for normal development of the biliary tract
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Development 129:1819-28. 2002
    ..The transcription factors that control the development of the biliary tract are unknown...
  27. pmc MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    Int J Parasitol 41:397-403. 2011
    ..These results indicate that miR-221-mediated translational suppression controls ICAM-1 expression in epithelial cells in response to C. parvum infection...
  28. pmc Relating function to branching geometry: a micro-CT study of the hepatic artery, portal vein, and biliary tree
    Timothy L Kline
    Department of Physiology and Biomedical Engineering, Physiological Imaging Research Laboratory, Mayo Clinic, College of Medicine, Rochester, Minn 55905, USA
    Cells Tissues Organs 194:431-42. 2011
    ....
  29. ncbi Helical CT cholangiography in the evaluation of the biliary tract: application to the diagnosis of choledocholithiasis
    T Cabada Giadas
    Radiology Service, Hospital de Navarra, C Irunlarrea, 3, 31008 Pamplona, Navarra, Spain
    Abdom Imaging 27:61-70. 2002
    We evaluated the role of helical computed tomographic (HCT) cholangiography in the study of the biliary tract, especially in the detection of choledocholithiasis, and compared it with direct cholangiography.
  30. ncbi Intraoperative choledochoscopy for the management of liver hydatid cysts opened to the biliary tract
    Nikola Nikolov Vladov
    J Gastroenterol Hepatol 19:836-7. 2004
  31. ncbi Laparoscopic ultrasonography: an additional method for potentially preventing biliary tract injury
    J Machi
    Surg Endosc 22:802-3. 2008
  32. ncbi Development of the biliary tract
    Frederic P Lemaigre
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Mech Dev 120:81-7. 2003
  33. ncbi Biliary tract of the rat as observed by scanning electron microscopy of cast samples
    T Murakami
    Section of Human Morphology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    Arch Histol Cytol 64:439-47. 2001
    The three-dimensional distribution of the biliary tract in the rat was studied by scanning electron microscopy of biliary casts...
  34. ncbi In vivo spectroscopic characterization of porcine biliary tract tissues: first step in the development of new biliary tract imaging devices
    Edward H Livingston
    Department of Biomedical Engineering, University of Texas at Arlington, Arlington, TX, USA
    Ann Biomed Eng 37:201-9. 2009
    ..The purpose of this work is to characterize the NIR optical properties of bile containing structures that are needed for later development of a clinically useful probe...
  35. ncbi Blunt trauma of the pancreas and biliary tract: a multimodality imaging approach to diagnosis
    Avneesh Gupta
    Department of Radiology, Boston University Medical Center and Boston University, Mass, USA
    Radiographics 24:1381-95. 2004
    ..Bile duct injuries can be suggested with CT, which may show ascites and associated liver injuries, and can be confirmed with hepatobiliary scintigraphy...
  36. ncbi Prediction of lymph node metastasis and perineural invasion of biliary tract cancer by selected features from cDNA array data
    Katsuhiko Murakawa
    Department of Surgical Oncology, Division of Cancer Diagnostics and Therapeutics, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Surg Res 122:184-94. 2004
    To better understand the nature of the malignancy of biliary tract carcinoma and evaluate the feasibility of its prediction by gene expression profiles.
  37. ncbi Visualization of the biliary tract using gadobenate dimeglumine: preliminary findings
    Fatma Bilge Ergen
    Department of Radiology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey
    J Comput Assist Tomogr 32:54-60. 2008
    ..To compare contrast-enhanced magnetic resonance (MR) cholangiography (CE-MRC) performed with gadobenate dimeglumine with T2-weighted MRC (T2-MRC) for visualization of the bile ducts in nondilated biliary systems...
  38. ncbi Concordance of second-order portal venous and biliary tract anatomies on MDCT angiography and MDCT cholangiography
    James S Chen
    Abdominal Imaging, Department of Radiology, University of California, San Francisco, Box 0628, C 324C, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 184:70-4. 2005
    We sought to investigate the concordance between second-order portal venous and biliary tract anatomies using MDCT angiography and MDCT cholangiography.
  39. pmc Claudin-1, -2, -3, -4, -7, -8, and -10 protein expression in biliary tract cancers
    Zsuzsanna Nemeth
    2nd Department of Pathology, Semmelweis University, Budapest, Hungary
    J Histochem Cytochem 57:113-21. 2009
    b>Biliary tract cancers are relatively common malignant gastrointestinal tumors in the elderly...
  40. pmc Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development
    Pallavi B Limaye
    Department of Pathology, Division of Transplantation Pathology, Montefiore University Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Lab Invest 88:865-72. 2008
    ....
  41. ncbi Mirizzi syndrome complicating an anomalous biliary tract: a novel cause of a hugely elevated CA19-9
    Andrew G N Robertson
    University Department of Surgery, Royal Free Hospital and Royal Free and University College School of Medicine, University College London, UK
    Eur J Gastroenterol Hepatol 19:167-9. 2007
    ..surgery, biliary obstruction owing to a gallstone (Type II Mirizzi) was found to be complicating a congenital biliary tract anomaly...
  42. ncbi Tegaserod does not alter fasting or meal-induced biliary tract motility
    Robert S Fisher
    Temple University Hospital, Philadelphia, USA
    Am J Gastroenterol 99:1342-9. 2004
    ..The effect of tegaserod on nongut digestive organs, such as the gallbladder and biliary tract, has not been previously investigated...
  43. ncbi Effect of different bile duct flush solutions on biliary tract preservation injury of donated livers for transplantation
    D X Cui
    Department of Hepatopancreatobiliary Surgery, Shengjing Hospital Affiliated to China Medical University, Shenyang City, China
    Transplant Proc 42:1576-81. 2010
    The objective of this study was to explore the effect of various bile duct flush (BDF) solutions on biliary tract preservation of donated livers in rats.
  44. ncbi The gallbladder and biliary tract in cystic fibrosis
    Michael P Curry
    Liver Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Gastroenterol Rep 7:147-53. 2005
    ..Liver transplantation can be performed successfully in patients with end-stage liver disease. Future treatments involve targeted gene therapy and activation of mutant forms of the cystic fibrosis transmembrane conductance regulator...
  45. ncbi Acute pancreatitis caused by tapeworm in the biliary tract
    Yu Min Liu
    Division of Gastroenterology, Department of Internal Medicine, and Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
    Am J Trop Med Hyg 73:377-80. 2005
    ..Although parasites are not an uncommon cause of pancreatitis, especially in disease-endemic areas, it is rare for Taenia to cause acute pancreatitis...
  46. ncbi The role of bacteria in gallstone pathogenesis
    A Swidsinski
    Innere Klinik, Gastroenterologie, , Germany
    Front Biosci 6:E93-103. 2001
    ....
  47. ncbi Abdominal MDCT: liver, pancreas, and biliary tract
    W Dennis Foley
    Medical College of Wisconsin, Department of Radiology, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Semin Ultrasound CT MR 25:122-44. 2004
    ..In this chapter, a rational approach to hepatic and pancreatic MDCT acquisition is outlined with emphasis on circulatory phases and contrast material pharmacokinetics as well as biological characteristics of focal parenchymal lesions...
  48. ncbi Biliary secretion of moxifloxacin in obstructive cholangitis and the non-obstructed biliary tract
    D Schwab
    Department of Medicine I, University Erlangen Nurnberg, Erlangen, Germany
    Aliment Pharmacol Ther 22:417-22. 2005
    ..Biliary secretion of antibiotic agents into the bile is considerably compromised by biliary obstruction, a precondition of bacterial cholangitis. Moxifloxacin may be advantageous according to secretion and antimicrobial spectrum...
  49. ncbi Italian multicenter experience of Roux-en-Y gastric bypass on vertical banded gastroplasty: four-year results of effective and safe innovative procedure enabling traditional endoscopic and radiographic study of bypassed stomach and biliary tract
    Stefano Cariani
    Department of General Surgery and Obesity Surgery, University of Bologna, Bologna, Italy
    Surg Obes Relat Dis 4:16-25. 2008
    ..A previously published study demonstrated that complete occlusion of the gastrogastric outlet was not necessary to lose weight. We have developed an open RYGB-on-vertical banded gastroplasty procedure...
  50. ncbi Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice
    Ujjal Poddar
    Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Nucl Med 45:1488-92. 2004
    ..This study aimed at identifying the role of ursodeoxycholic acid (UDCA), a choleretic agent, in conjunction with hepatobiliary scintigraphy in differentiating extrahepatic biliary atresia from neonatal hepatitis...
  51. ncbi Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats
    Takahiro Sasamoto
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 21:26-31. 2006
    ....
  52. ncbi Definitive exclusion of biliary atresia in infants with cholestatic jaundice: the role of percutaneous cholecysto-cholangiography
    Benedict C Nwomeh
    Division of Pediatric Surgery, Columbus Children s Hospital, The Ohio State University College of Medicine and Public Health, 700 Children s Drive, Suite ED379, Columbus, OH 43205, USA
    Pediatr Surg Int 23:845-9. 2007
    ..Identification of a normal gall bladder on sonogram is highly predictive of the absence of biliary atresia. Further confirmation can be accurately obtained by a combination of PCC and percutaneous liver biopsy...
  53. ncbi Biliary disease after liver transplantation: the experience of the King Faisal Specialist Hospital and Research Center, Riyadh
    Mohammad S Khuroo
    Medicine, Section of Gastroenterology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Gastroenterol Hepatol 20:217-28. 2005
    The biliary tract has been referred to as the "Achilles heel" of liver transplantation...
  54. ncbi Parameters obtained by hepatobiliary scintigraphy have significant correlation with biochemical factors early after liver transplantation
    H A Kansoul
    Division of Transplantation Surgery, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Acta Radiol 48:597-604. 2007
    ..Early postoperative hepatobiliary scintigraphy after liver transplantation is performed worldwide, but data on its significance for graft function are currently limited...
  55. ncbi Hepatobiliary pathology
    Jay H Lefkowitch
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, USA
    Curr Opin Gastroenterol 24:269-77. 2008
    ..Studies are reviewed from the past year concerning the histopathology of liver and biliary diseases and their pathogenesis...
  56. ncbi Differential effects of hydroxyacetophenone analogues on the transcytotic vesicular pathway in rat liver
    Lukmanee Tradtrantip
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand
    Eur J Pharmacol 547:152-9. 2006
    ..These results demonstrate a variable effect of hydroxyacetophenones on the transcytotic vesicular pathway reflecting different choleretic mechanisms and therapeutic potential...
  57. pmc Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease
    Tatyana V Masyuk
    Mayo Medical School, Clinic and Foundation, 200 First St, SW, Rochester, MN 55905, USA
    Am J Pathol 165:1719-30. 2004
    ..Our results suggest that the PCK rat is a useful model for studies of biliary cystogenesis and treatment options of inherited cystic liver disease...
  58. ncbi Biliary strictures following liver transplantation: past, present and preventive strategies
    Sharad Sharma
    Nazih Zuhdi Transplant Institute, Baptist Medical Center, Oklahoma City, OK 73112, USA
    Liver Transpl 14:759-69. 2008
    ..In the case of live donors, judicious use of intraoperative cholangiograms, minimal dissection of the hilar plate, and perpendicular transection of the duct constitute the underlying principals for obtaining a vascularized duct...
  59. ncbi The keratin cytoskeleton in liver diseases
    Kurt Zatloukal
    Institute of Pathology, Medical University of Graz, A 8036 Graz, Austria
    J Pathol 204:367-76. 2004
    ..The functional relevance of keratins in human diseases has recently been underlined by the identification of mutations in keratin genes in patients with liver cirrhosis...
  60. ncbi Biliary parasitic diseases including clonorchiasis, opisthorchiasis and fascioliasis
    Jae Hoon Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Abdom Imaging 33:157-65. 2008
    ..In the biliary phase, the flukes are demonstrated in the intra- and extrahepatic bile ducts and the gallbladder as small intraluminal flat objects, sometimes moving spontaneously. Bile ducts are dilated...
  61. ncbi A prospective study of standardized nonsurgical therapy in the management of biliary anastomotic strictures complicating liver transplantation
    Andrew P Holt
    Liver Transplantation and Hepatology Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    Transplantation 84:857-63. 2007
    ....
  62. ncbi High frequency of cholestasis in generalized pustular psoriasis: Evidence for neutrophilic involvement of the biliary tract
    Manuelle Viguier
    Department of Dermatology 1, Hopital Saint Louis, Assistance Publique Hôpitaux de Paris and Université Paris 7, Paris, France
    Hepatology 40:452-8. 2004
    ..Biliary involvement related to neutrophilic cholangitis should be added to the spectrum of extracutaneous manifestations of this disease, and physicians should be aware of such a complication...
  63. ncbi Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats
    Jhy Wen Wu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Drug Metab Dispos 36:589-96. 2008
    ..These results together suggest that the phase II conjugative reaction of silibinin was blocked by treatment with DNM...
  64. ncbi Hardikar syndrome: new features
    J Rainer Poley
    Department of Pediatrics, Section of Pediatric Gastroenterology and Hepatology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Am J Med Genet A 146:2473-9. 2008
    ..syndrome (HS) is a disorder of multiple anomalies predominantly characterized by cleft lip/palate, liver and biliary tract disease, intestinal malrotation, obstructive uropathy, and retinopathy...
  65. ncbi Papillomatosis of intra- and extrahepatic biliary tree: Successful treatment with liver transplantation
    George Imvrios
    Department of Transplant Surgery, Aristotle University, Hippokration Hospital, Thessaloniki, Greece
    Liver Transpl 13:1045-8. 2007
    ..Fifteen months' follow-up revealed a patient with normal graft function and with no clinically or laboratory findings of disease recurrence or cancer development...
  66. ncbi [Biliary complications following orthotopic liver transplantation. The Hungarian experience]
    Balazs Nemes
    Semmelweis Egyetem, Általános Orvostudományi Kar, Transzplantációs és Sebészeti Klinika Budapest
    Orv Hetil 149:963-73. 2008
    ..The authors observed the known risk factors in the Hungarian practice, and they also try to find unknown risk factors for biliary complications. They review the therapy of biliary complications...
  67. ncbi Dynamics of the vascular profile of the finer branches of the biliary tree in normal and diseased human livers
    Annette S H Gouw
    Department of Pathology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Hepatol 45:393-400. 2006
    ..An insufficient proliferative response and loss of bile ductules preceded bile duct loss whereas preservation of bile ductules mitigated bile duct loss...
  68. ncbi Aquaporins in the hepatobiliary system
    Anatoliy I Masyuk
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 43:S75-81. 2006
    ..Accumulating evidence suggests that AQPs are likely involved in canalicular and ductal bile secretion, gluconeogenesis and microbial infection and may have other novel roles that affect liver function...
  69. ncbi Safety of donor right hepatectomy for adult-to-adult living donor liver transplantation
    Toshiyuki Itamoto
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Transpl Int 19:177-83. 2006
    ..evaluations of liver remnant volume by CT volumetry and biliary variation by CT cholangiography are essential for performing safe donor hepatectomy, preventing hepatic insufficiency and minimizing the risk of biliary tract complications.
  70. ncbi Alteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide
    Yen Tong
    Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, South Australia, Australia
    Clin Exp Pharmacol Physiol 33:685-9. 2006
    ..0 +/- 1.1 mL/min; CLB 2.7 +/- 0.5 mL/min; L : P 87 +/- 14; and B : L 30 +/- 4). 4. In conclusion CL and CLB were reduced following treatment with LPS in a manner consistent with downregulation of both canalicular and sinusoidal transport...
  71. ncbi Posttraumatic bile leaks: role of diagnostic imaging and impact on patient outcome
    Keith W Fleming
    Department of Radiology, Boston University School of Medicine and Boston Medical Center, 88 East Newton Street, MA 02118, USA
    Emerg Radiol 12:103-7. 2006
    ..Patients with liver injury and free intraperitoneal bile leak have longer hospitalizations and undergo more therapeutic procedures than those without, who respond to conservative management...
  72. pmc Administration of granulocyte colony stimulating factor after liver transplantation leads to an increased incidence and severity of ischemic biliary lesions in the rat model
    Olaf Dirsch
    Institute of Pathology, University Hospital Cologne, Germany
    World J Gastroenterol 12:5021-7. 2006
    ..This study evaluated whether G-CSF treatment worsens liver perfusion following liver transplantation in the rat model...
  73. ncbi [Significant role of transporters in drug hepatobiliary transport]
    Jin Sun
    Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Yao Xue Xue Bao 40:680-5. 2005
  74. ncbi Hepatobiliary transporters and drug-induced cholestasis
    Christiane Pauli-Magnus
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
    Hepatology 44:778-87. 2006
    ..This review summarizes current knowledge about the function of hepatobiliary uptake and efflux systems and discusses factors that might predispose to drug-induced cholestasis...
  75. ncbi Highly resolved free-breathing magnetic resonance cholangiopancreatography in the diagnostic workup of pancreaticobiliary diseases in infants and young children--initial experiences
    Juergen F Schaefer
    Department of Diagnostic Radiology, University of Tuebingen, 72076 Tuebingen, Germany
    J Pediatr Surg 41:1645-51. 2006
    ..The study aimed to investigate the new technology of the MRCP in infants with suspected pancreaticobiliary diseases...
  76. ncbi Gadobenate dimeglumine-enhanced liver MRI as the sole preoperative imaging technique: a prospective study of living liver donors
    Su Kyung An
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, 28, Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    AJR Am J Roentgenol 187:1223-33. 2006
    ..The objective of our study was to determine whether gadobenate dimeglumine-enhanced MRI is practical as the sole preoperative imaging technique for the examination of living liver donors...
  77. ncbi High risk of bacterobilia in advanced experimental chronic fasciolosis
    M A Valero
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Av Vicente Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    Acta Trop 100:17-23. 2006
    ..e. therapeutic strategies should not only include a parasitic treatment but also consider the possibility of bacterial co-infection...
  78. ncbi Copper impairs biliary epithelial cells and induces protein oxidation and oxidative DNA damage in the isolated perfused rat liver
    Albena Alexandrova
    Laboratory of Free Radical Processes, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Exp Toxicol Pathol 58:255-61. 2007
    ..The results suggest that toxic effects of copper in the isolated perfused rat liver may involve biliary epithelial cells and they are associated with lipid peroxidation, protein oxidation, and oxidative DNA damage...
  79. ncbi Relationship between right portal and biliary systems based on reclassification of the liver
    Akihiro Cho
    Department of Surgery, Chiba Cancer Center Hospital, 666 2 Nitonachou, Chuouku, Chiba 260 8717, Japan
    Am J Surg 193:1-4. 2007
    ....
  80. ncbi Hepatobiliary and pancreatic MRI and MRCP findings in patients with HIV infection
    Mehmet Bilgin
    Department of Radiology, University Hospital Giessen and Marburg, Giessen, Germany
    AJR Am J Roentgenol 191:228-32. 2008
    ..The purpose of this article is to describe the spectrum of MRI and MR cholangiopancreatography (MRCP) findings of hepatic, pancreatic, and biliary manifestations in patients with HIV infection...
  81. ncbi Dual-radionuclide simultaneous gastric emptying and bile transit study after gastric surgery with double-tract reconstruction
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Japan
    Ann Nucl Med 19:185-91. 2005
    ..We applied a simultaneous dual-radionuclide method with a hepatobiliary imaging and gastric emptying study to evaluate physiologic alterations occurring after surgery...
  82. ncbi Disorders of bile formation and biliary transport
    Gitit Tomer
    Division of Pediatric Gastroenetrology, One Gustave L Levy Place, Box 1656, Mount Sinai Medical Center, New York, NY 10029, USA
    Gastroenterol Clin North Am 32:839-55, vi. 2003
    ..Defects in bile acid biosynthesis and aminophospholipid transport may be responsive to medical or non-transplant surgical approaches...
  83. ncbi Molecular aspects of bile formation and cholestasis
    Marco Arrese
    Departmento de Gastroenterologi a, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 347, 8320000 Santiago, Chile
    Trends Mol Med 9:558-64. 2003
    ..Potential implications of this knowledge for the design of new therapies of cholestatic disorders are also discussed...
  84. ncbi Mechanism of hepatobiliary transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335), and its xenobiotic taurine conjugate (Z-335-Tau) in rats
    Yoshihiro Kawabata
    Central Research Laboratories, ZERIA Pharmaceutical Corporation, Ltd, 2512 1, Oshikiri, Kohnan machi, Ohsato gun, Saitama 360 0111, Japan
    J Pharm Sci 92:67-76. 2003
    ..The mdr2 and/or BSEP/spgp might contribute to a part of total biliary excretion of Z-335-Tau, however, these transporters have not played a major role in the biliary excretion of Z-335-Tau...
  85. ncbi Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2
    David R Johnson
    Environmental Health and Occupational Medicine Center, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160 7417, USA
    Toxicol Sci 66:16-26. 2002
    ..In conclusion, Mrp2 is the inducible efflux transporter responsible for increased biliary SH excretion and bile flow after administration of some drug-metabolizing enzyme inducers...
  86. ncbi Imaging of hepatic transplantation
    Hero K Hussain
    Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Clin Liver Dis 6:247-70, viii-ix. 2002
    ....
  87. ncbi Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes
    F Lakehal
    , , , Paris, France
    Chem Res Toxicol 14:694-701. 2001
    ..These metabolic events may contribute to the pathogenesis of drug-induced cholangiopathies...
  88. ncbi [A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study]
    J M P Lima
    Serviço de Medicina Nuclear, Hospitais da Universidade de Coimbra Coimbra Portugal
    Rev Esp Med Nucl 22:244-9. 2003
    ..Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency...
  89. ncbi Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data
    K Ueda
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 297:1036-43. 2001
    ..The present analysis demonstrates a strategic rationale for predicting drug interactions involving biliary excretion using in vitro systems to avoid any false negative predictions...
  90. ncbi Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas
    M P Buisine
    Laboratoire de Biochimie et de Biologie Moleculaire, Hopital C Huriez, CHRU, Lille, France
    J Histochem Cytochem 48:1667-76. 2000
    ..Taken together, these data show complex spatio-temporal regulation of the mucin genes and suggest a possible regulatory role for mucin gene products in gastroduodenal epithelial cell differentiation...
  91. ncbi The effect of erythromycin on bile excretion and proximal small bowel motility following divided gastric bypass surgery: a prospective randomized placebo-controlled trial
    Neal W Wilkinson
    Department of Surgery, Eisenhower Army Medical Center, Fort Gordon, GA, USA
    Obes Surg 12:765-72. 2002
    ..The study was designed to examine the effect of erythromycin on small bowel motility in a placebo-controlled trial of post gastric bypass patients utilizing a standardized nuclear medicine test...
  92. ncbi Diagnostic workup before laparoscopic cholecystectomy--which diagnostic tools should be used?
    J Fahlke
    Department of Surgery, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Hepatogastroenterology 48:59-65. 2001
    ..As there is no general agreement regarding the appropriate preoperative diagnostic workup, we compared different diagnostic methods as to their value in detecting unknown accompanying diseases and complications...
  93. ncbi Influence of hypotonic stress on the biliary excretion of doxorubicin in Wistar and TR- rats
    M Gaugg
    Department of Pathophysiology, University of Vienna, AKH, Austria
    Anticancer Res 21:2745-51. 2001
    ..Our data show that in the liver of both strains, exposure to a hypotonic medium stimulates DOX excretion, presumably by activation of P-gp and mrp2 during RVD...
  94. ncbi Ultrasound of non-vascular complications in the post liver transplant patient
    A S Shaw
    Department of Radiology, King s College Hospital, London, UK
    Clin Radiol 58:672-80. 2003
    ..The types, frequency and features of non-vascular complications are described in this review, with emphasis on biliary complications, types of fluid collections and the features of post-transplant lymphoproliferative disorder...
  95. pmc Techniques, clinical applications and limitations of 3D reconstruction in CT of the abdomen
    Michael M Maher
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02184, USA
    Korean J Radiol 5:55-67. 2004
    ..In addition, this article briefly discusses the disadvantages of thin-slice acquisitions including increasing numbers of transverse images, which must be reviewed by the radiologist...
  96. ncbi The role of 99mTc mebrofenin hepatobiliary scanning in predicting common bile duct stones in patients with gallstone disease
    Mohammed Iqbal
    Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India
    Nucl Med Commun 25:285-9. 2004
    ..ERCP has the disadvantage of being invasive, and there is a risk of complications; while MRCP is costly and is not widely available...
  97. ncbi Quantitative evaluation of capacity-limited hepatobiliary transport based on hepatocellular diffusion model by MULTI(FEM)
    M Higashimori
    Graduate School of Pharmaceutical Science, Kyoto University, Japan
    J Pharmacokinet Pharmacodyn 28:415-44. 2001
    ..3 microg/ml. In conclusion, MULTI(FEM) is useful for evaluation of capacity-limited local disposition...
  98. pmc Cholyllysyl fluroscein and related lysyl fluorescein conjugated bile acid analogues
    C O Mills
    Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Yale J Biol Med 70:447-57. 1997
    ....
  99. ncbi A prospective study of bile leaks after laparoscopic cholecystectomy
    D M Hasl
    Department of Surgery, Riverside Methodist Hospital, 3535 Olentangy River Road, Columbus, OH 43214, USA
    Surg Endosc 15:1299-300. 2001
    ..3%, as compared with historical reports of 30% to 44% for open cholecystectomy...
  100. ncbi Anomalous development of the hepatobiliary system in the Inv mouse
    M V Mazziotti
    Department of Surgery, Washington University School of Medicine, Washington School of Medicine, St Louis, MO, USA
    Hepatology 30:372-8. 1999
    ....
  101. ncbi The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids
    C M Frijters
    Departments of Gastrointestinal and Liver Diseases and Clinical Chemistry, Academic Medical Center, FO 221, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Lipid Res 40:1950-8. 1999
    ..These data confirm that the efficiency of NBD-SM extraction depends on the lipid composition and suggest that the canalicular membrane outer leaflet of Mdr2 -/- mice has a reduced PC content...

Research Grants63

  1. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ....
  2. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ..for those of Hispanic origin, because cancers with higher rates among Hispanics, such as stomach, liver, biliary tract, and uterine cervix, are generally associated with extreme pain (American Cancer Society, 2009)...
  3. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ....
  4. MRI Imaging Biomarkers of ARPKD Kidney and Liver Disease
    Christopher A Flask; Fiscal Year: 2013
    ..Kidney failure develops in 40-50% of affected children by age 10. ARPKD liver disease (CHF) is a biliary tract lesion characterized by both bile duct proliferation and dilatation as well periportal fibrosis...
  5. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    CARA LYNN MACK; Fiscal Year: 2011
    ..The overall goal of this research program is to use these molecular and immunological insights as a basis for development of future therapeutic and preventative strategies for this important disease. ..
  6. cPLA2alpha and COX-2 in Cholangiocarcinoma
    Tong Wu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholangiocarcinoma is a highly malignant neoplasm of the biliary tract and its incidence and mortality is rising...
  7. Hhex-a Homeobox Gene Necessary for Liver Development
    Clifford W Bogue; Fiscal Year: 2010
    ..Additionally, this research will shed important insight into the pathogenesis of diseases of the biliary tract, including biliary atresia and polycystic liver disease.
  8. Pathophysiology of cholangiocyte responses to microbial pathogens
    STEVEN P O'HARA; Fiscal Year: 2013
    ..Here we concentrate on cholangiocyte recognition and response to pathogens or pathogen-derived products. The biliary tract is periodically exposed to microbial-derived toxins (e.g...
  9. Isolation, Identification and Characterization of a Toxin Causing Biliary Atresia
    Rebecca G Wells; Fiscal Year: 2013
    ..glomulifera toxins~ and 3. To identify and characterize damage pathways induced by D. glomulifera toxins in mammalian models. ..
  10. Endocannabinoid signaling in alcohol induced hepatic steatosis
    LEAH YU LIU; Fiscal Year: 2013
    ..These studies will not only reveal the mechanisms of EC signaling during ALD, but also seek to identify novel therapeutic targets and drugs for the treatment of patients with ALD. ..
  11. Role of Sensory Neuropeptides in the Regulation of Biliary Function
    Fanyin Meng; Fiscal Year: 2013
    ..This newly acquired fundamental knowledge about regulation of differentiation by sensory neuropeptide-regulated mRNAs and miRNAs in biliary progenitors will advance the general field of cholangiocyte biology. ..
  12. MicroRNA involvement in the regulation of biliary epithelium
    Florin Selaru; Fiscal Year: 2013
    ..CCAs are cancers arising from the biliary tract. They are the 2nd most common primary hepatobiliary cancers in the United States, and their incidence is ..
  13. Calmodulin Regulates Fas-Mediated Apoptosis: A Target for Cancer Therapy
    Jay M McDonald; Fiscal Year: 2013
    ..All of these diseases are very important health problems for the Veteran's population. ..
  14. A confocal endomicroscope for clinical research
    Michael H Nathanson; Fiscal Year: 2010
    ..in disorders characterized by mucosal inflammation, and lymphangiogenesis in cholangiocarcinoma and in other biliary tract diseases...
  15. Mechanisms of Carcinogenesis in Biliary Epithelia
    Gregory J Gores; Fiscal Year: 2013
    ..remain to understand and define the cellular mechanisms contributing to the development and progression of biliary tract cancer, termed cholangiocarcinoma (CCA)...
  16. Intracellular calcium in the treatment of polycystic kidney and liver diseases
    Sergio A Gradilone; Fiscal Year: 2010
    ..It is hypothesized that abnormalities in the sensory machinery of cholangiocyte cilia are central to hepatic cyst formation. ..
  17. Autocrine/Paracrine Regulation of Intrahepatic Bile Duct Growth
    GIANFRANCO D ALPINI; Fiscal Year: 2013
    ....
  18. Novel approaches to develop a treatment for cryptosporidiosis
    Christopher D Huston; Fiscal Year: 2013
    ..low in cost, selectively toxic for Cryptosporidium at concentrations relevant within the small intestine and biliary tract, and capable of eliminating the parasite from patients in the absence of effective host immunity...
  19. Mechanisms of Survival Signaling in Biliary Epithelia
    Tushar Patel; Fiscal Year: 2013
    ..Chronic biliary tract inflammation predisposes to cholangiocarcinoma formation...
  20. Molecular Response and Imaging-based Combination Strategies for Optimal PDT
    Tayyaba Hasan; Fiscal Year: 2013
    ..Project 2 proposes to improve the survival and quality of life of patients with pancreatic or biliary tract carcinoma using PDT in clinical studies...
  21. Generating 3-D lung organoids in vitro from human pluripotent stem cells
    James M Wells; Fiscal Year: 2013
    ....
  22. Mechanisms of Bile Duct Morphogenesis
    Ben Z Stanger; Fiscal Year: 2013
    ..abstract_text> ..
  23. GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREE
    GIANFRANCO D ALPINI; Fiscal Year: 2010
    ..It is our firm belief that the results of these studies will provide information that will not only allow us to better understand cholangiocyte pathobiology but will also lead to treatments for cholestatic liver diseases. ..
  24. Forward genetic analysis of biliary system formation in zebrafish
    Takuya Sakaguchi; Fiscal Year: 2009
    ..These studies in zebrafish ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human liver diseases. ..
  25. Forward genetic analysis of biliary system formation in zebrafish
    Takuya Sakaguchi; Fiscal Year: 2012
    ..These studies in zebrafish ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human liver diseases. ..
  26. CRYPTOSPORIDIUM DHFR AS A CHEMOTHERAPEUTIC TARGET
    Richard Nelson; Fiscal Year: 1992
    ..watery diarrhea with dehydration and malnutrition; extraintestinal complications include involvement of the biliary tract, pancreas, and lungs...
  27. A Tumor-Specific Nanoimmunocomplex Markedly Improves MR Imaging
    Esther Chang; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  28. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..3. Compare and contrast the mechanisms of activation of ABCA1 via the cAMP responsive and the LXRalpha/RXR- responsive pathways. ..
  29. NOVEL TREATMENT OF REFRACTORY GI MALIGNANCIES
    Scott Wadler; Fiscal Year: 1999
    ..Responses were observed in biliary tract (1/2), gastric (5/8) and pancreatic (1/6) carcinoma...
  30. Biliary oxysterols and cholangiocarcinoma
    RAHUL P KUVER; Fiscal Year: 2010
    ..abstract_text> ..
  31. Molecular Pathogenesis of Cystic Fibrosis Liver Disease
    Martin Carey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Pathogenic Mechanisms of Virus Induced Biliary Atresia
    GREGORY TIAO; Fiscal Year: 2009
    ..We will determine if a similar process occurs in vivo. We will also determine if the NF-kappaB intracellular pathway is the mechansim by which RRV infection induces chemokine production. ..
  33. BIOSYNTHESIS OF LIVER ALKALINE PHOSPHATASE
    Norman Sussman; Fiscal Year: 1993
    ..The significance of the work lies in gaining an understanding into the process of AP synthesis as it relates to the liver in normal and diseased states...
  34. Aberrant kinase signaling in cholangiocarcinoma
    Tushar Patel; Fiscal Year: 2003
    ..Chronic inflammation of the biliary tract such as in primary sclerosing cholangitis or hepatolithiasis is characterized by alterations in the cytokine ..
  35. Hex - a Homeobox Gene Essential for Liver Development
    CLIFFORD BOGUE; Fiscal Year: 2007
    ..Specific Aim 3. Elucidate the transcriptional network regulated by Hhex during liver and biliary tract development...
  36. Novel therapies for biliary cancers in BK5.erbB-2 mice
    John DiGiovanni; Fiscal Year: 2007
    ..erbB2 transgenic mice as a model for testing novel therapeutic strategies for biliary tract cancer. Recently, we developed the BK5...
  37. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..is an essential hepatic function in both normal physiology and in pathophysiologic diseases of the liver, biliary tract, and cardiovascular system...
  38. Mechanisms of Carcinogenesis in Biliary Epithelia
    Gregory Gores; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  39. IMMUNE-MEDIATED BILE DUCT INJURY IN BILIARY ATRESIA
    SHERI KRAMS; Fiscal Year: 2001
    ..We anticipate that these studies will provide unique insights into the pathogenesis of biliary atresia and form the groundwork for future studies related to this severe and enigmatic liver disease. ..
  40. CONTROL OF MOTILITY IN THE SPHINCTER OF ODDI
    Gary Mawe; Fiscal Year: 2001
    ..from disease of the biliary system, and SO malfunction is a major contributor to morbidity associated with biliary tract disease...
  41. Mechanism of NOD.IDD3/10/17/18/9(LD) Liver Disease
    William Ridgway; Fiscal Year: 2005
    The goal of this proposal is to determine mechanisms of a novel autoimmune and biliary tract disease discovered in the NOD.ldd3/10/17/18/9(LD) mouse...
  42. PATHOGENESIS OF BILE DUCT INJURY IN AIDS
    Michael Gerber; Fiscal Year: 1990
    ..We hope that these studies will lead to a better understanding of bile duct injury and to a more rational management of liver disease in patients with AIDS...
  43. HEPATOBILIARY TRANSPORT AND METABOLISM OF GLUTATHIONE
    Nazzareno Ballatori; Fiscal Year: 1991
    ....
  44. DYSREGULATION OF CHOLANGIOCYTE APOPTOSIS BY CYTOKINES
    Tushar Patel; Fiscal Year: 2003
    ..This information has the promise of ultimately contributing to the development of specific therapies for the cholangiopathies as well as interventions to prevent neoplasia. ..
  45. Phenotypic Determinants of Murine Cholelithiasis
    Martin Carey; Fiscal Year: 2004
    ..abstract_text> ..
  46. OBESITY, LEPTIN AND GALLSTONE PATHOGENESIS
    Henry Pitt; Fiscal Year: 2005
    ..These studies should lead to unique strategies for gallstone prevention, which is the ultimate goal of this research. ..
  47. PROGENITOR CELLS IN IN VITRO LIVER EXPLANT CULTURES
    Lopa Mishra; Fiscal Year: 2000
    ..A. Rashid (JHU). The study of such in vitro explant cultures not only promises to a better understanding of liver formation, but also may in the future be utilized for tissue engineered composites as form of liver restoration therapy. ..
  48. PROTECTION OF HOST TISSUES FROM FDURD TOXICITY
    Jonathan Maybaum; Fiscal Year: 2002
    ..Finally he will test the therapeutic efficacy of transduction with TS adenovirus in a canine model, which is the only model that is currently known to closely mimic the toxic syndrome seen in humans. ..
  49. THE ROLE OF NOTCH SIGNALING IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..abstract_text> ..
  50. SALT TRANSPORT MECHANISMS IN GALLBLADDER EPITHELIUM
    Luis Reuss; Fiscal Year: 1999
    ..These studies are expected to provide important new information on the mechanisms of regulation of ion transport in gallbladder, in other biliary-tract epithelia and in absorptive epithelia such as those of the intestine and the kidney. ..
  51. AGING IMPAIRMENT OF GUT MUCOSAL IMMUNITY
    DOUGLAS SCHMUCKER; Fiscal Year: 1990
    ..cells in the wall of the small intestine is transported by epithelial cells (enterocytes, gall bladder or biliary tract epithelium) into the gut via receptor-mediated endocytosis, vesicular translocation and exocytosis...
  52. NEURAL CONTROL OF THE GALLBLADDER
    Gary Mawe; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): A hallmark of biliary tract disease is a decrease in the tone of gallbladder smooth muscle (GBSM), and a decrease in the responsiveness of GBSM to excitatory agonists...
  53. MECHANISMS OF HEPATOBILIARY TRANSPORT OF MERCURY
    Thomas Clarkson; Fiscal Year: 1991
    ....
  54. REAL TIME OPTICAL FEEDBACK CONTROL OF LASER LITHOTRIPSY
    David Rosen; Fiscal Year: 1993
    ....
  55. Proteomics of Biliary Atresia
    Robert Heuckeroth; Fiscal Year: 2005
    ..will provide insight about which serum protein changes in infants with biliary atresia result primarily from biliary tract obstruction...
  56. AUTOIMMUNE MECHANISM IN ULCERATIVE COLITIS
    Kiron Das; Fiscal Year: 2001
    ..This mAb has unique organ distribution such as colon, biliary tract, skin, eyes and joints...
  57. Biliary morphogenesis and bile canaliculi integration
    DAVID HOGANSON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. CANALICULAR MECHANISM OF BILE FORMATION
    James Crawford; Fiscal Year: 1999
    ..In so doing, insights may be gained into two key clinical problems: how bile secretory failure (cholestasis) develops; and how abnormal biliary lipid secretion may give rise to cholesterol gallstone formation. ..
  59. AE2 CI/HCO3 Exchanger and Transepithelial Ion Transport
    LARA GAWENIS; Fiscal Year: 2005
    ....
  60. OUTCOME ASSESSMENT/PATIENTS WITH BILIARY TRACT DISEASE
    J Schwartz; Fiscal Year: 1991
    The objective of this project is to improve the evaluation, management and health outcomes of patients with biliary tract disease...
  61. In Vitro Systems to Predict Hepatobiliary Toxicity
    Charles Tyson; Fiscal Year: 2002
    ..vitro liver cell assay to determine or predict potential dose-limiting hepatocellular injury and injury to the biliary tract by anticancer agents in humans...
  62. In Vitro Systems to Predict Hepatobiliary Toxicity
    Carol Green; Fiscal Year: 2005
    ..vitro liver cell assay to determine or predict potential dose-limiting hepatocellular injury and injury to the biliary tract by anticancer agents in humans...
  63. PATHOBIOLOGY OF BILIARY EPITHELIA
    Nicholas Larusso; Fiscal Year: 1990
    ..Tight Junctions in Epithelial Assembly Funding is requested to cover the costs for planning and conduction the workshop and for travel and per diem expenses and honoraria for speakers...