digestive system

Summary

Summary: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).

Top Publications

  1. ncbi Formation of the digestive system in zebrafish. I. Liver morphogenesis
    Holly A Field
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:279-90. 2003
  2. ncbi Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development
    Lilia Gonzalez-Ceron
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Mexico
    J Med Entomol 40:371-4. 2003
  3. ncbi Peritrophic matrix proteins
    R L Tellam
    CSIRO Tropical Agriculture, Queensland, Australia
    Insect Biochem Mol Biol 29:87-101. 1999
  4. pmc Capsule-transmitted gut symbiotic bacterium of the Japanese common plataspid stinkbug, Megacopta punctatissima
    Takema Fukatsu
    Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Appl Environ Microbiol 68:389-96. 2002
  5. pmc Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
    Janneth Rodrigues
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Science 329:1353-5. 2010
  6. ncbi Vertebrate endoderm development
    J M Wells
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Cell Dev Biol 15:393-410. 1999
  7. pmc Acetic acid bacteria, newly emerging symbionts of insects
    Elena Crotti
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche DISTAM, Universita degli Studi di Milano, 20133 Milan, Italy
    Appl Environ Microbiol 76:6963-70. 2010
  8. pmc Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species
    Nicolas Vodovar
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 102:11414-9. 2005
  9. pmc Gut symbiotic bacteria of the genus Burkholderia in the broad-headed bugs Riptortus clavatus and Leptocorisa chinensis (Heteroptera: Alydidae)
    Yoshitomo Kikuchi
    Natural History Laboratory, Faculty of Science, Ibaraki University, Mito 310 8512, Japan
    Appl Environ Microbiol 71:4035-43. 2005
  10. pmc Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation
    Yoshitomo Kikuchi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    Appl Environ Microbiol 73:4308-16. 2007

Detail Information

Publications270 found, 100 shown here

  1. ncbi Formation of the digestive system in zebrafish. I. Liver morphogenesis
    Holly A Field
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:279-90. 2003
    Despite the essential functions of the digestive system, much remains to be learned about the cellular and molecular mechanisms responsible for digestive organ morphogenesis and patterning...
  2. ncbi Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development
    Lilia Gonzalez-Ceron
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Mexico
    J Med Entomol 40:371-4. 2003
    ..The overall midgut bacterial infection in mosquito field populations may influence P. vivax transmission, and could contribute to explain the annual variations in malaria incidence observed in the area...
  3. ncbi Peritrophic matrix proteins
    R L Tellam
    CSIRO Tropical Agriculture, Queensland, Australia
    Insect Biochem Mol Biol 29:87-101. 1999
    ..The review concludes with speculation about the biological functions of the proteins in this matrix...
  4. pmc Capsule-transmitted gut symbiotic bacterium of the Japanese common plataspid stinkbug, Megacopta punctatissima
    Takema Fukatsu
    Research Institute of Biological Resources, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Appl Environ Microbiol 68:389-96. 2002
    ....
  5. pmc Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
    Janneth Rodrigues
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Science 329:1353-5. 2010
    ..In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory...
  6. ncbi Vertebrate endoderm development
    J M Wells
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Cell Dev Biol 15:393-410. 1999
    ..We discuss possible mechanisms that regulate how undifferentiated endoderm becomes specified into a myriad of cell types that populate the respiratory and gastrointestinal tracts...
  7. pmc Acetic acid bacteria, newly emerging symbionts of insects
    Elena Crotti
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche DISTAM, Universita degli Studi di Milano, 20133 Milan, Italy
    Appl Environ Microbiol 76:6963-70. 2010
    ..Taken together, the data indicate that AAB represent novel secondary symbionts of insects...
  8. pmc Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species
    Nicolas Vodovar
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 102:11414-9. 2005
    ..We found that natural infection by Pe induces a dramatic change in larval gene expression. In addition to immunity genes, our study identifies many genes associated with Pe pathogenesis that have been previously unreported...
  9. pmc Gut symbiotic bacteria of the genus Burkholderia in the broad-headed bugs Riptortus clavatus and Leptocorisa chinensis (Heteroptera: Alydidae)
    Yoshitomo Kikuchi
    Natural History Laboratory, Faculty of Science, Ibaraki University, Mito 310 8512, Japan
    Appl Environ Microbiol 71:4035-43. 2005
    ..chinensis did not form clades but were intermingled in the phylogeny, suggesting that horizontal transmission of the symbiont might have occasionally occurred between populations and species of the bugs...
  10. pmc Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation
    Yoshitomo Kikuchi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    Appl Environ Microbiol 73:4308-16. 2007
    ....
  11. ncbi Inter- and intraspecific comparison of the bacterial assemblages in the hindgut of humivorous scarab beetle larvae (Pachnoda spp.)
    Janet Andert
    Department of Biogeochemistry, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    FEMS Microbiol Ecol 74:439-49. 2010
    ..A comparison with a previously obtained clone library of the same species corroborates both the similarities and the intraspecific variance of the hindgut microbiota...
  12. ncbi Lipid metabolism in Rhodnius prolixus (Hemiptera: Reduviidae): role of a midgut triacylglycerol-lipase
    Luciano A M Grillo
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Insect Biochem Mol Biol 37:579-88. 2007
    ..These activities were inhibited by phenylmethylsulphonyl fluoride (PMSF). On the second day after blood meal, when digestion is very intense, TAG-lipase activities were maximal and then gradually decreased...
  13. ncbi Biological clocks and the digestive system
    L A Scheving
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Vanderbilt University, Digestive Disease Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    Gastroenterology 119:536-49. 2000
    ..but also in peripheral organs, suggesting that the ability to keep time may also belong to cells within the digestive system. This article reviews several classic examples of circadian variation in the digestive system, with an ..
  14. ncbi Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
    XuBo Niu
    Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China
    Dev Biol 367:197-207. 2012
    ..Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system.
  15. ncbi Properties of purified gut trypsin from Helicoverpa zea, adapted to proteinase inhibitors
    Mariateresa Volpicella
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Bari, Italy
    Eur J Biochem 270:10-9. 2003
    ..frequently feed on plants expressing protease inhibitors. Apparently, their digestive system can adapt to the presence of protease inhibitors...
  16. pmc A simple model host for identifying Gram-positive virulence factors
    D A Garsin
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:10892-7. 2001
    ..We exploit the apparent parallels between Gram-positive infection in simple and more complex organisms by using the nematode to identify an E. faecalis virulence factor, ScrB, which is relevant to mammalian pathogenesis...
  17. ncbi Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development
    Margaret L Kirby
    Neonatal Perinatal Research Institute, Division of Neonatology, Department of Pediatrics, Box 3179, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 253:175-88. 2003
    ....
  18. ncbi The ultrastructural investigation of the midgut in the quill mite Syringophilopsis fringilla (Acari, Trombidiformes: Syringophilidae)
    S A Filimonova
    Zoological Institute, Parasitology, Russian Academy of Sciences, Universitetskaya embankment 1, 199034 St Petersburg, Russia
    Arthropod Struct Dev 38:303-13. 2009
    ..Evacuation of the fecal masses occurs periodically. Mitotic figures have been observed occasionally in the epithelial cells of the anterior midgut...
  19. pmc Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies
    Nagila Secundino
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Cell Microbiol 12:906-18. 2010
    ....
  20. ncbi Detection and identification of a novel lactic acid bacterial flora within the honey stomach of the honeybee Apis mellifera
    Tobias C Olofsson
    Microbiology Laboratory at Campus Helsingborg, Department of Cell and Organism Biology, Lund University Campus Helsingborg, P O Box 882, Helsingborg, 25108, Sweden
    Curr Microbiol 57:356-63. 2008
    ....
  21. ncbi Mining an Ostrinia nubilalis midgut expressed sequence tag (EST) library for candidate genes and single nucleotide polymorphisms (SNPs)
    B S Coates
    USDA ARS, Corn Insect and Crop Genetics Research Unit, Genetics Laboratory, Iowa State University, Ames, Iowa 50011, USA
    Insect Mol Biol 17:607-20. 2008
    ..This O. nubilalis larval midgut EST collection is a resource for gene discovery, expression information, and allelic variation for use in genetic marker development...
  22. pmc The Anopheles gambiae adult midgut peritrophic matrix proteome
    R R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Insect Biochem Mol Biol 39:125-34. 2009
    ..Among them were nine new chitin-binding peritrophic matrix proteins, expanding the list from three to twelve peritrophins. Lastly, we provide a model for the putative interactions among the proteins identified in this study...
  23. pmc pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans
    M A Horner
    Huntsman Cancer Institute, Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 USA
    Genes Dev 12:1947-52. 1998
    ..We suggest that pha-4 is a key component of a transcription-based mechanism to endow cells with pharyngeal organ identity...
  24. ncbi Commensal host-bacterial relationships in the gut
    L V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Science 292:1115-8. 2001
    ....
  25. pmc Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:15882-7. 2007
    ..We provide evidence for the in vivo role of chondroitin sulfate proteoglycans in Plasmodium falciparum invasion of the midgut and insight into the molecular mechanisms mediating parasite-mosquito interactions...
  26. ncbi Identification, cloning and expression of a Cry1Ab cadherin receptor from European corn borer, Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae)
    Ronald D Flannagan
    Pioneer Hi Bred International Inc, 7301 NW 62nd Avenue, P O Box 85, Johnston, IA 50131 0085, USA
    Insect Biochem Mol Biol 35:33-40. 2005
    ..1 microg/ml. These results in combination suggest strongly that a cadherin-like protein acts as receptor and is involved with Cry1Ab toxicity in O. nubilalis...
  27. ncbi Nil per os encodes a conserved RNA recognition motif protein required for morphogenesis and cytodifferentiation of digestive organs in zebrafish
    Alan N Mayer
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Development 130:3917-28. 2003
    ..Antisense-mediated knockdown of npo results in organ hypoplasia, and overexpression of npo causes an overgrowth of gastrointestinal organs. Thus, npo is a gene essential for a key step in the gut morphogenetic sequence...
  28. ncbi Identification of two new peritrophic membrane proteins from larval Trichoplusia ni: structural characteristics and their functions in the protease rich insect gut
    Ping Wang
    Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
    Insect Biochem Mol Biol 34:215-27. 2004
    ..Alignment of the chitin binding sequences suggested that CBP1 and CBP2 evolved by gene duplication and the tandem chitin binding domains in the proteins arose from domain duplications...
  29. pmc A lipophosphoglycan-independent development of Leishmania in permissive sand flies
    Jitka Myskova
    Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, Prague 2, Czech Republic
    Microbes Infect 9:317-24. 2007
    ..infantum by Lutzomyia longipalpis; this event led to the establishment of L. infantum/chagasi in Latin America...
  30. ncbi Developmental microbial ecology of the neonatal gastrointestinal tract
    R I Mackie
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Am J Clin Nutr 69:1035S-1045S. 1999
    ..Further advances in our understanding of developmental microbial ecology in the neonatal gastrointestinal tract are dependent on the application of these modern molecular techniques...
  31. ncbi Molecular basis of Colorado potato beetle adaptation to potato plant defence at the level of digestive cysteine proteinases
    Kristina Gruden
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Insect Biochem Mol Biol 34:365-75. 2004
    ..Gene expression analysis revealed that the intestains A and C, but not B, are induced twofold by potato plants with high levels of proteinase inhibitors...
  32. ncbi Plasma membranes from insect midgut cells
    Walter R Terra
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, 05513 970 Sao Paulo, SP, Brazil
    An Acad Bras Cienc 78:255-69. 2006
    ..The role played by the microvillar and perimicrovillar proteins in insect midgut physiology is reviewed here trying to provide a coherent picture of data and highlighting further research areas...
  33. pmc Indirect effects of temperature on stink bug fitness, via maintenance of gut-associated symbionts
    Simone S Prado
    Empresa Brasileira de Pesquisa Agropecuaria, Londrina, PR, Brazil
    Appl Environ Microbiol 76:1261-6. 2010
    ..This work illustrates the need to better understand the biology of animal-symbiont associations and the consequences of local climate for the dynamics of these interactions...
  34. ncbi The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes
    J M Villalon
    Case Western Reserve University, School of Medicine, Department of Genetics, Cleveland, OH 44106, USA
    J Insect Physiol 49:891-5. 2003
    ..PM disruption by two independent means (chitinase and anti-PM antibodies) consistently increases the rate of blood digestion. The significance of these results in relation to PM function is discussed...
  35. pmc Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae)
    Meghan A Betcher
    Division of Environmental and Biomolecular Systems, Oregon Health and Science University, Beaverton, Oregon, United States of America
    PLoS ONE 7:e45309. 2012
    ..gills have been studied extensively in several species, the abundance and distribution of microbes in the digestive system have not been adequately addressed...
  36. pmc Expression of nesfatin-1/NUCB2 in rodent digestive system
    Ai qing Zhang
    Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 16:1735-41. 2010
    To observe the regional distributions and morphological features of nesfatin-1/nucleobindin-2 (NUCB2) immunoreactive (IR) cells in the rodent digestive system.
  37. pmc A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells
    H Nakagoshi
    Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Genes Dev 12:2724-34. 1998
    ..Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia...
  38. ncbi Molecular structure of the peritrophic membrane (PM): identification of potential PM target sites for insect control
    P Wang
    Boyce Thompson Institute, Cornell University, Ithaca, New York 14853, USA
    Arch Insect Biochem Physiol 47:110-8. 2001
    ....
  39. ncbi Characterization of a membrane-bound aminopeptidase purified from Acyrthosiphon pisum midgut cells. A major binding site for toxic mannose lectins
    Plinio T Cristofoletti
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    FEBS J 273:5574-88. 2006
    ..In addition to oligopeptide digestion, APN is proposed to be associated with amino-acid-absorption processes which, in contrast with aminopeptidase activity, may be hampered on lectin binding...
  40. pmc Controls on gut phosphatisation: the trilobites from the Weeks Formation Lagerstätte (Cambrian; Utah)
    Rudy Lerosey-Aubril
    Department of Palaeontology and Historical Geology, Senckenberg Research Institute, Frankfurt am Main, Germany
    PLoS ONE 7:e32934. 2012
    ..However, in some specimens from the Weeks Formation, the phosphatisation extends to the entire digestive system, suggesting that trilobites might have had some biological particularities not observed in modern arthropods...
  41. ncbi Stem cells of the beetle midgut epithelium
    James B Nardi
    Department of Entomology, University of Illinois, 320 Morrill Hall, 505 S Goodwin Avenue, Urbana, IL 61801, United States
    J Insect Physiol 56:296-303. 2010
    ..This organization of stem cell pouches in insect midguts closely parallels that of regenerative crypts in mammalian intestines...
  42. pmc Multilocus microsatellite markers for molecular typing of Candida glabrata: application to analysis of genetic relationships between bloodstream and digestive system isolates
    A Enache-Angoulvant
    AP HP, Hopital Bicetre, Service de Bactériologie Virologie Hygiène, Laboratoire de Parasitologie Mycologie, Kremlin Bicetre, France
    J Clin Microbiol 48:4028-34. 2010
    ..The demonstration of the occurrence of microevolution in digestive strains supports the idea that C. glabrata can be a persistent commensal of the human gut...
  43. ncbi A microarray-based analysis of transcriptional compartmentalization in the alimentary canal of Anopheles gambiae (Diptera: Culicidae) larvae
    M Neira Oviedo
    The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, FL 32080, USA
    Insect Mol Biol 17:61-72. 2008
    ..Furthermore, our data support the notion that the region encompassing the hindgut and Malpighian tubes plays important roles in avoiding the excretion of nutrients, as well as in xenobiotic detoxification...
  44. ncbi Identification of novel Bacillus thuringiensis Cry1Ac binding proteins in Manduca sexta midgut through proteomic analysis
    Rebecca J McNall
    Department of Biochemistry and Molecular Biology, University of Georgia, 413 Biological Sciences Building, 120 Cedar Street, Athens, GA 30602, USA
    Insect Biochem Mol Biol 33:999-1010. 2003
    ..Aminopeptidase N was the only GPI-anchored protein identified. Actin, aminopeptidase N, and membrane alkaline phosphatase were confirmed as accurate protein identifications through western blots...
  45. pmc Proteomic analysis of the mosquito Aedes aegypti midgut brush border membrane vesicles
    Alexandra Popova-Butler
    Department of Biochemistry, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    J Insect Physiol 55:264-72. 2009
    ..Three proteins, arginine kinase, putative allergen and actin are shown to be the most predominant proteins in the sample. The total number of 36 proteins detected by both methods represents the most abundant proteins in the BBMV...
  46. ncbi Storage and secretion of Ag-Aper14, a novel peritrophic matrix protein, and Ag-Muc1 from the mosquito Anopheles gambiae
    M Devenport
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Cell Tissue Res 320:175-85. 2005
    ..After blood feeding, Ag-Aper14 is secreted and incorporated into the PM that surrounds the ingested blood...
  47. ncbi Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium
    Stephen P Voght
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Cell Metab 5:195-205. 2007
    ....
  48. ncbi Contribution of gut bacteria to digestion and development of the velvetbean caterpillar, Anticarsia gemmatalis
    L E Visôtto
    Departamento de Bioquimica e Biologia Molecular, Instituto de Biotecnologia Aplicada à Agropecuária BIOAGRO, Universidade Federal de Vicosa, Vicosa, MG 36571 000, Brazil
    J Insect Physiol 55:185-91. 2009
    ....
  49. ncbi Mutations affecting development of zebrafish digestive organs
    M Pack
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:321-8. 1996
    ..These gastrointestinal mutations may be informative with regard to patterning and crucial lineage decisions during organogenesis, and may be relevant to diabetes, congenital dysmorphogenesis and disorders of cell proliferation...
  50. ncbi Aquaporins in the digestive system
    Toshiyuki Matsuzaki
    Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Med Electron Microsc 37:71-80. 2004
    Fluid transfer such as secretion and absorption is one of the major functions of the digestive system. Aquaporins are water channel proteins providing water transfer across the cellular membrane...
  51. ncbi Niche heterogeneity determines bacterial community structure in the termite gut (Reticulitermes santonensis)
    Hong Yang
    Fachbereich Biologie, Mikrobielle Okologie, Universitat Konstanz, 78457 Konstanz, Germany
    Environ Microbiol 7:916-32. 2005
    ....
  52. ncbi Cellular expression of gut chitinase mRNA in the gastrointestinal tract of mice and chickens
    Masako Suzuki
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan
    J Histochem Cytochem 50:1081-9. 2002
    ....
  53. pmc Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa
    Antonio M Mendes
    Imperial College London, Division of Cell and Molecular Biology, Faculty of Natural Sciences, South Kensington Campus, London, United Kingdom
    PLoS Pathog 4:e1000069. 2008
    ..falciparum field isolates have been established by direct experimentation. Importantly, they validate for semi-field human malaria transmission the concept of parasite antagonists and agonists...
  54. ncbi Storage and secretion of the peritrophic matrix protein Ag-Aper1 and trypsin in the midgut of Anopheles gambiae
    M Devenport
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Insect Mol Biol 13:349-58. 2004
    ..Newly synthesized Ag-Aper1 protein was again detected within the midgut epithelial cells at 60 h after blood ingestion...
  55. ncbi The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis
    M E Rogers
    Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, UK
    Parasitology 124:495-507. 2002
    ..Collectively, these data support the role of the PSG in the transmission of leishmaniasis, by conditioning the midgut environment for metacyclogenesis and altering the feeding ability of infected sandflies...
  56. pmc Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice
    T G Schwan
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Clin Microbiol 38:382-8. 2000
    ..Therefore, the temporal synthesis of OspC by spirochetes only in feeding ticks that were infected prior to the blood meal suggests that this surface protein is involved in transmission from tick to mammal but not from mammal to tick...
  57. ncbi Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion
    Dina Vlachou
    European Molecular Biology Laboratory, Heidelberg, Germany
    Curr Biol 15:1185-95. 2005
    ..Previously, we have identified hemolymph factors that can antagonize or promote parasite development...
  58. ncbi Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical tr
    Wolfgang A Krueger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen
    Am J Respir Crit Care Med 166:1029-37. 2002
    ..496-1.046). Surveillance cultures from tracheobronchial, oropharyngeal, and gastric secretions and from rectal swabs did not show any evidence for the selection of resistant microorganisms in the patients receiving prophylaxis...
  59. ncbi Digestive lipases: from three-dimensional structure to physiology
    N Miled
    Laboratoire de Lipolyse Enzymatique, CNRS IFR1 UPR 9025, 31, Chemin Joseph Aiguier, 13402 cedex 20, Marseille, France
    Biochimie 82:973-86. 2000
    ..The biochemical, histochemical and clinical studies as well as the 3-D structures obtained will be a great help for a better understanding of the structure-function relationships of digestive lipases...
  60. pmc TRP channels in the digestive system
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Curr Pharm Biotechnol 12:24-34. 2011
    ..Consequently, blockers of these TRP channels have been developed, and their clinical usefulness has yet to be established...
  61. ncbi Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects
    K Staehling-Hampton
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Dev Biol 164:502-12. 1994
    ....
  62. ncbi Mobilization of chrysene from soil in a model digestive system
    Jaswinder K Minhas
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Environ Toxicol Chem 25:1729-37. 2006
    ....
  63. ncbi Anatomy of the stomatogastric nervous system associated with the foregut in Drosophila melanogaster and Calliphora vicina third instar larvae
    Roland Spiess
    Department of Neurobiology, Institute for Zoology, University of Bonn, Poppelsdorfer Schloss, 53115 Bonn, Germany
    J Morphol 269:272-82. 2008
    ..Future electrophysiological studies of the motor circuits in the SNS of Drosophila will profit from parallel studies of the homologous but more accessible structures in Calliphora...
  64. ncbi Occurrence of serotonin immunoreactivity in the central nervous system and midgut of adult female Tabanus nigrovittatus (Diptera: Tabanidae)
    Aaron T Haselton
    Department of Entomology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    J Med Entomol 43:252-7. 2006
    ..In the midgut, a fine network of immunoreactive processes was observed running along the outer surface of the midgut, with a decrease in innervation toward the posterior region of the midgut...
  65. pmc 16S rRNA gene-based identification of midgut bacteria from field-caught Anopheles gambiae sensu lato and A. funestus mosquitoes reveals new species related to known insect symbionts
    Jenny M Lindh
    Department of Genetics, Microbiology and Toxicology, Stockholm University, 106 91 Stockholm, Sweden
    Appl Environ Microbiol 71:7217-23. 2005
    ..The isolates will be further investigated for their suitability for a paratransgenic Anopheles mosquito...
  66. ncbi Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion
    Valéria Páscoa
    Laboratório de Biotecnologia and Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil
    Insect Biochem Mol Biol 32:517-23. 2002
    ..Taken all together, our data indicate that the PM performs a central role in heme detoxification in this insect...
  67. pmc Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development
    Nelson S Yee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 5:e312. 2007
    ..These data show that functional interactions between Pol III subunits have been conserved during eukaryotic evolution and support the utility of zebrafish as a model vertebrate for analysis of Pol III function...
  68. pmc Polyester synthesis genes associated with stress resistance are involved in an insect-bacterium symbiosis
    Jiyeun Kate Kim
    Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609 735, Korea
    Proc Natl Acad Sci U S A 110:E2381-9. 2013
    ..In vitro culturing analyses confirmed vulnerability of the PHA gene mutants to environmental stresses, suggesting that PHA may play a role in resisting stress under symbiotic conditions. ..
  69. ncbi Plasmodium falciparum ookinete invasion of the midgut epithelium of Anopheles stephensi is consistent with the Time Bomb model
    L A Baton
    Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Parasitology 129:663-76. 2004
    ....
  70. ncbi How do malaria ookinetes cross the mosquito midgut wall?
    Luke A Baton
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Trends Parasitol 21:22-8. 2005
    ..We also propose a novel hypothesis, the Cellular Treadmill model, to explain the movement of ookinetes through multiple adjacent midgut cells...
  71. ncbi Characterization of major midgut proteinase cDNAs from Helicoverpa armigera larvae and changes in gene expression in response to four proteinase inhibitors in the diet
    L N Gatehouse
    Horticulture and Food Research Institute, Palmerston North, New Zealand
    Insect Biochem Mol Biol 27:929-44. 1997
    ..Changing the protein level of the diet did not affect trypsin mRNA levels, but chymotrypsin mRNA levels decreased with increasing dietary protein...
  72. ncbi Recent developments on polyphenol–protein interactions: effects on tea and coffee taste, antioxidant properties and the digestive system
    Prasun Bandyopadhyay
    Unilever R and D Bangalore, 64 Main Road, Whitefield, Bangalore 560066, India
    Food Funct 3:592-605. 2012
    ..trends and patterns (2005 onwards) in polyphenol-protein interaction studies focusing on the characterization of the complex, the effect of this complex formation on tea and coffee taste, antioxidant properties and the digestive system.
  73. ncbi The association of Western flower thrips, Frankliniella occidentalis, with a near Erwinia species gut bacteria: transient or permanent?
    E J de Vries
    Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Kruislaan 320, Amsterdam, 1098 SM, The Netherlands
    J Invertebr Pathol 77:120-8. 2001
    ..The same type of bacteria was present in all life stages of the thrips and was found to persist in the thrips populations for at least 2 years (more than 50 generations)...
  74. ncbi Leishmania chagasi: lipophosphoglycan characterization and binding to the midgut of the sand fly vector Lutzomyia longipalpis
    Rodrigo P P Soares
    Laboratory of Medical Entomology, Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima, 1715, 30190 002, Belo Horizonte, MG, Brazil
    Mol Biochem Parasitol 121:213-24. 2002
    ..These results are consistent with the proposal that a New World Leishmania species, similar to Old World species, adapts the expression of terminally exposed sugars of its LPG to mediate parasite-sand fly interactions...
  75. ncbi The fine structure of the midgut in the mite Anystis baccarum (L.) (Acari, Actinedida: Anystidae)
    Svetlana A Filimonova
    Zoological Institute, Russian Academy of Sciences, 199034 St Petersburg, Russia
    Arthropod Struct Dev 37:299-309. 2008
    ..All types of secretory granules were observed close to the apical plasmalemma...
  76. ncbi Involvement of ghrelin-growth hormone secretagogue receptor system in pathoclinical profiles of digestive system cancer
    Zhigang Wang
    Department of General Surgery, Shanghai Jiaotong University Affiliated No 6 Hospital, Shanghai 200233, China
    Acta Biochim Biophys Sin (Shanghai) 39:992-8. 2007
    ..For the first time, we identified the distribution of ghrelin receptor in digestive system cancers...
  77. ncbi Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Westmead, NSW 2145, Australia
    Development 138:4511-22. 2011
    ....
  78. ncbi Morphologic analysis of the zebrafish digestive system
    Andrew J Trotter
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Vic, Australia
    Methods Mol Biol 546:289-315. 2009
    ..Despite optical transparency of embryos, the internal position of the developing digestive system and its close juxtaposition with the yolk initially made morphological analysis relatively challenging, ..
  79. pmc Exceptionally preserved Cambrian trilobite digestive system revealed in 3D by synchrotron-radiation X-ray tomographic microscopy
    Mats E Eriksson
    Department of Geology, Lund University, Lund, Sweden
    PLoS ONE 7:e35625. 2012
    ..analogous to the labrum of euarthropods and that it was a sophisticated element closely integrated with the digestive system. This study also briefly addresses the preservational bias of the 'Orsten' fauna, particularly the near-..
  80. pmc Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti
    Doug E Brackney
    Arthropod Infectious Disease Laboratory, 1692 Campus Delivery, Department of Microbiology, Immunology and Pathology at Colorado State University, Fort Collins, CO 80523, USA
    J Insect Physiol 56:736-44. 2010
    ..A subfamily of midgut serine proteases and/or that A. aegypti has evolved an array of proteases with a broad range of substrate specificities for rapid, efficient digestion of bloodmeals...
  81. ncbi Ultrastructural changes of the midgut epithelium in Isohypsibius granulifer granulifer Thulin, 1928 (Tardigrada: Eutardigrada) during oogenesis
    Magdalena M Rost-Roszkowska
    Department of Animal Histology and Embryology, University of Silesia, Bankowa 9, 40 007, Katowice, Poland
    Protoplasma 248:405-14. 2011
    ..At the end of oogenesis, autophagy also intensifies in midgut epithelial cells, which is probably caused by the great amount of reserve material. Midgut epithelium of analyzed species takes part in the yolk precursor synthesis...
  82. ncbi The effect of peptide absorption on PepT1 gene expression and digestive system hormones in rainbow trout (Oncorhynchus mykiss)
    Teresa Ostaszewska
    Warsaw University of Life Sciences, Division of Ichthyobiology and Fisheries, Faculty of Animal Science, Ciszewskiego 8, 02 786 Warsaw, Poland
    Comp Biochem Physiol A Mol Integr Physiol 155:107-14. 2010
    ..Leptin immunoreactivity was also observed in hepatocyte cytoplasm and pancreatic acinar cells. Gastrin/CCK immunoreactive cells were present in the proximal intestine and pyloric caeca...
  83. ncbi Fine structure of the midgut epithelium in two Archaeognatha, Lepismachilis notata and Machilis hrabei (Insecta), in relation to its degeneration and regeneration
    Magdalena M Rost-Roszkowska
    Department of Animal Histology and Embryology, University of Silesia, Bankowa 9, Katowice, Poland
    Protoplasma 247:91-101. 2010
    ..Some of them proliferate, while the others differentiate into epithelial cells. We compared the organisation of the midgut epithelium of M. hrabei and L. notata with zygentoman species, which have just been described...
  84. ncbi Uptake, flow, and digestion of casein and green fluorescent protein in the digestive system of Lygus hesperus Knight
    Javad Habibi
    Department of Entomology, University of Missouri, Columbia, USA
    Arch Insect Biochem Physiol 50:62-74. 2002
    ..Dextran was used as a control to monitor the non-absorptive flow rate of ingesta through the digestive system. Fluorescent tracking of FITC-conjugates of casein and dextran, as well as immunoblotting and ..
  85. ncbi Microscopic anatomy of pycnogonida: II. Digestive system. III. Excretory system
    W H Fahrenbach
    Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Morphol 268:917-35. 2007
    The digestive system of several species of sea spiders (Pycnogonida, Arthropoda) was studied by electron microscopy. It is composed of the foregut inside a long proboscis, a midgut and a hindgut...
  86. pmc Hypothermia does not increase the risk of infection: a case control study
    Marlijn Kamps
    Department of Intensive Care, Radboud University Nijmegen Medical Centre PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Crit Care 15:R48. 2011
    ..The aim of this study was to investigate the incidence of infections in patients treated with hypothermia and normothermia while receiving SDD...
  87. ncbi Histological and ultrastructural characterization of the alimentary system of solifuges (Arachnida, Solifugae)
    A E Klann
    Ernst Moritz Arndt Universitat Greifswald, Zoologisches Institut and Museum, Johann Sebastian Bach Strabetae 11 12, 17487 Greifswald, Germany
    J Morphol 271:225-43. 2010
    ..In contrast to the midgut, the epithelium of the hindgut consists of only one type of cell overlain by a thin cuticle. Digested residuals are stored in the hindgut until defecation...
  88. ncbi Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study
    D C Bergmans
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 164:382-8. 2001
    ..cross infection, prevention and control; respiration, artificial, adverse effects; antibiotics, administration and dosage infection control methods; pneumonia, etiology, prevention and control; intubation, intratracheal, adverse effects..
  89. ncbi Interaction of two Bacillus thuringiensis delta-endotoxins with the digestive system of Lygus hesperus
    Sandra L Brandt
    Biological Control of Insects Research Laboratory, US Department of Agriculture, Agricultural Research Service, 1503 S Providence Rd, Columbia, MO 65203, USA
    Curr Microbiol 48:1-9. 2004
    ..Proteolytic processing of the toxins also occurred in vivo, within the digestive system of L. hesperus. Excreted CrylAc and Cry2Ab retained activity toward lepidopteran larvae...
  90. ncbi Characterization of proteases in the digestive system of spiny lobster (Panulirus interruptus)
    Laura E Celis-Guerrero
    Centro de Investigaciones Biologicas del Noroeste CIBNOR, PO Box 129, La Paz, B C S 23000, Mexico
    Mar Biotechnol (NY) 6:262-9. 2004
    ..Also, such enzymes become alternative tools for use in biotechnologies...
  91. ncbi Endogenous beta-galactosidase activity in amphioxus: a useful histochemical marker for the digestive system
    C Canestro
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 645 Av Diagonal, 08028 Barcelona, Spain
    Dev Genes Evol 211:154-6. 2001
    ..of beta-galactosidase activity was used to monitor morphological and functional differentiation of the digestive system and the posteriorization of the endodermal structures in retinoic-acid treated embryos...
  92. ncbi Effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in the digestive system of tilapia (Oreochromis niloticus)
    Wei Dai
    Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, Zhejiang University, Hangzhou, 310029, People s Republic of China
    Biol Trace Elem Res 127:124-31. 2009
    ..the effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in tissues of the digestive system. The results showed that the Pb accumulation in tissues increased with the dietary Pb concentrations...
  93. ncbi Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland
    Laura Canesi
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Aquat Toxicol 87:272-9. 2008
    ..The results demonstrate that short-term exposure to environmentally relevant concentrations of EDC mixtures can interfere with the lysosomal function, redox-related enzyme activities and gene transcription of mussel digestive gland...
  94. ncbi Ultrastructure of the midgut and hindgut of Derocheilocaris remanei (Crustacea, Mystacocarida)
    L Herrera-Alvarez
    Departamento de Biología Animal I, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    J Morphol 244:177-89. 2000
    ..A single basic cell type forms the hindgut epithelium. The suggested function for the hindgut is the transport and ejection of waste products...
  95. ncbi Metal accumulation and binding protein induction in Mytilus galloprovincialis, Scapharca inaequivalvis, and Tapes philippinarum from the Lagoon of Venice
    P Irato
    Department of Biology, University of Padova, Italy
    Arch Environ Contam Toxicol 44:476-84. 2003
    ..inaequivalvis are sentinel organisms and can be used specifically for Zn pollution; (3) T. philippinarum accumulates Cu in the digestive gland more readily than the other two bivalves and therefore has the highest MT...
  96. ncbi Effects of 17beta-estradiol on mussel digestive gland
    Laura Canesi
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Gen Comp Endocrinol 153:40-6. 2007
    ....
  97. ncbi Effects of vibrio challenge on digestive gland biomarkers and antioxidant gene expression in Mytilus galloprovincialis
    Laura Canesi
    Dipartimento di Biologia, Universita di Genova, Italy
    Comp Biochem Physiol C Toxicol Pharmacol 152:399-406. 2010
    ..Moreover, the results support the hypothesis that host responses to bacteria may be taken into account when interpreting biomarker data in ecotoxicological studies...
  98. ncbi Organogenesis in the budding process of the freshwater bryozoan Cristatella mucedo Cuvier, 1798 (Bryozoa, Phylactolaemata)
    Thomas Schwaha
    Department of Theoretical Biology, Morphology Section, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
    J Morphol 272:320-41. 2011
    ..Nonetheless, our results show that comparative organogenesis can contribute to phylactolaemate systematics and, when more data are available, possibly to that of other bryozoan classes and bilaterian phyla...
  99. ncbi Bacterial contributions to mammalian gut development
    Lora V Hooper
    Center for Immunology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Trends Microbiol 12:129-34. 2004
  100. ncbi Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues
    Kimberly D Tremblay
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Dev Biol 280:87-99. 2005
    ....
  101. pmc Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    Saurabh Mehandru
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Fl, New York, NY 10016, USA
    J Exp Med 200:761-70. 2004
    ..Given the importance of the mucosal compartment in HIV-1 pathogenesis, further study to elucidate the significance of the changes observed here is critical...

Research Grants62

  1. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..by applicant): Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
  2. UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM
    Ezra Burstein; Fiscal Year: 2013
    ..in the GI tract, particularly the esophagus and colon;cancer prevention and screening;morphogenesis of the digestive system;obesity, liver steatosis, lipid metabolism and gallstone disease;immune responses in the liver and acute ..
  3. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..11) Regenerative Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
  4. Calcium-sensing receptor signaling in the regulation of colonic epithelial cells
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2012
    ..signal transduction pathways play a critical role in the regulation of multiple functions of the digestive system, including cell proliferation, inflammation and promotion of CRC...
  5. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..Area - (11) Regenerative Medicine Specific challenge topic - 11-DK-101 Promote regeneration and repair in the digestive system, liver, pancrease, kidneys, hematologic, and urological system. 3...
  6. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..Homeostasis in the digestive system is also maintained in part by chemical sensors present on different subtypes of enteroendocrine cells...
  7. Targeting Myofibroblast for Intestinal Epithelial Regeneration
    Hongmiao Sheng; Fiscal Year: 2010
    ..11) Regenerative Medicine and Specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, Hematologic, and urological system...
  8. Trafficking mechanisms for secretory vesicles in pancreatic duct epithelial cells
    Duk Su Koh; Fiscal Year: 2013
    ..that may lead to therapeutic intervention and will be broadly relevant to treatment of disorders of the digestive system. PUBLIC HEALTH RELEVANCE: We seek to understand the cellular mechanisms of modulation of pancreatic duct ..
  9. Characterization of a mutation that affects feeding and digestion in Drosophila
    EDWARD BLUMENTHAL; Fiscal Year: 2009
    ..In focusing on a mutation in the fruit fly Drosophila that affects digestion and feeding behavior, this project will provide insight into the function of the human digestive system and its role in appetite control.
  10. Spatiotemporal Regulation of Intestinal Gene Expression
    Eric Sibley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lactase non-persistence (adult-type hypolactasia) results in digestive system malabsorption of lactose, the carbohydrate macronutrient present in milk...
  11. Intestinal Epithelial Function in Congenital Tufting Enteropathy
    MAMATA B SIVAGNANAM; Fiscal Year: 2013
    ..Discerning EpCAM's role should help us understand CTE, other diarrheal diseases and more about the lining of the normal digestive system.
  12. Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokines
    Albert Zlotnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mucosal sites include the oral cavity, trachea and bronchi, the digestive system and the female reproductive system...
  13. Functional Brain Imaging and Appetite-Related Hormones Pre and Post Obesity Surge
    Allan Geliebter; Fiscal Year: 2013
    ..Changes in brain responses to food stimuli as well as changes in appetite hormones produced by the digestive system will be assessed following two types of obesity surgery: 1) gastric bypass and 2) gastric banding...
  14. Epidemiology of Celiac Disease: A Population Based Study
    Joseph A Murray; Fiscal Year: 2010
    Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  15. Formation of the Enteric Nervous System
    Chen Ming Fan; Fiscal Year: 2013
    ..They control the movement, secretion, and absorption of the digestive system. Deficiency of enteric neurons causes abdominal distention and constipation, a condition of patients ..
  16. Mechanisms of alimentary chemosensation
    Steven D Munger; Fiscal Year: 2013
    ..In Aim 2, we will characterize the role of two hormones expressed in taste cells and in the digestive system, glucagon-like peptide-1 (GLP-1) and glucagon, in the modulation of taste sensitivity...
  17. Adaptation of Inquiry-Based Learning Modules For Health Science Literacy
    DEE PETERSON; Fiscal Year: 2010
    ..Concepts surrounding digestive system structure and function as well as the role of metabolism will frame the curriculum...
  18. Genetics of Taste Perception
    Alexander A Bachmanov; Fiscal Year: 2013
    ..Taste also influences food processing by the digestive system. Consequently, understanding the mechanisms underlying this sense is central to our ability to control intake ..
  19. Emory Epithelial Pathobiology Research Development Center
    CHARLES PARKOS; Fiscal Year: 2012
    ..services to a group of highly specialized and interactive epithelial biologists and pathobiologists in the digestive system with the intention of enhancing research capability, promoting new research directions, and fostering ..
  20. Role of Vagal Afferents in Maintainence of Body Weight and Glucose Homeostasis
    Swalpa Udit; Fiscal Year: 2013
    ..derangements in the gut-to-brain axis, or the response of central neural pathways to information from the digestive system, have been implicated in obesity and Type II diabetes...
  21. Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Diseas
    Jorge A Bezerra; Fiscal Year: 2013
    ..areas and diseases: 1) Chronic liver disease, 2) Inflammatory and diarrheal diseases, 3) Obesity and the digestive system, and 4) Development and digestive diseases...
  22. CURE: DIGESTIVE DISEASES RESEARCH CENTER
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2013
    ..of new knowledge about cellular, molecular and physiological processes that control the function of the digestive system and translation of this knowledge into development of therapy for patients with digestive diseases...
  23. STRUCTURE AND ROLE(S) OF GASTRIC AND THYMIC PEPTIDES
    Robert Carraway; Fiscal Year: 1980
    ..and immunohistochemistry we have detected NT-related activity throughout the central nervous system (CNS) and digestive system of the rat, as well as in the chicken and rat thymus gland...
  24. PEDIATRIC GASTROENTEROLOGY RESEARCH TRAINING
    Phillip I Tarr; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The digestive system is critical for the well-being of individuals and of populations...
  25. Expression of Human Therapeutic Proteins in Transgenic Tobacco Chloroplasts
    Henry Daniell; Fiscal Year: 2010
    ..of therapeutic proteins expressed in plant cells offers several advantages including protection in the digestive system by bioencapsulation, followed by slow release in the gut;elimination of expensive purification steps, the ..
  26. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2004
    ..are expected to provide valuable new information on both the stimulatory effects of food on the human digestive system and the nutritional value of modern nutritional support techniques, and help determine why elemental diets ..
  27. NOVEL ENZYME/PRODRUG STRATEGY FOR CANCER GENE THERAPY
    Alnawaz Rehemtulla; Fiscal Year: 2001
    ..Since CPA is normally secreted from cells as a zymogen and requires cleavage by trypsin in the digestive system for functional activation, the applicants will generate CPA forms that can be expressed in mammalian cells as ..
  28. HORMONES AND THE PROGRAMMED DEATH IN PETROMYZON MARINUS
    AUGUST EPPLE; Fiscal Year: 1980
    ..endocrines and neurosecretions, (b) degenerative changes in the central nervous system, (c) atrophies in the digestive system, (d) kidney regression, (e) vascular pathologies; (3) autoradiography of steroid hormone and thyroxin target ..
  29. Fate Mapping and Analysis of the Definitive Endoderm
    Kimberly Tremblay; Fiscal Year: 2005
    ..Together these studies will provide for a more thorough understanding of the processes leading to the formation of a normal digestive system, allowing for the advancement of therapies for the diseased state.
  30. Regulation of Digestive Vesicular Glutamate Transporter
    Liqun Bai; Fiscal Year: 2007
    ..The long-term goal of our laboratory is to study the regulation of vesicular glutamate transporter in digestive system. The primary purpose of this proposal is to determine the mechanisms of glucose-induced regulation of ..
  31. DUKE/NIDDK FUNCTIONAL GENOMICS CENTER
    Joseph Nevins; Fiscal Year: 2002
    ..specialized DNA microarrays, that will specifically and uniquely enhance studies directed at the kidney and digestive system. This will be accomplished by generating cDNA and SAGE libraries so as to identify expressed sequences that ..
  32. Little Brain Big Brain Meeting
    David Linden; Fiscal Year: 2009
    ..This conference, called the Little Brain Big Brain, referring to the interaction between nerve cells in the digestive system and nerve cells in the brain and spinal cord, gathers scientists from around the world to study new ways to ..
  33. SEARCH FOR NOVEL GASTROINTESTINAL HORMONES
    Gary Gray; Fiscal Year: 1991
    ..We anticipate that such studies will shed further light on the regulatory mechanisms of the digestive system and will have implications toward understanding the pathogenesis of some digestive diseases.
  34. SENSORY AFFERENT INNERVATION OF THE DIGESTIVE SYSTEM
    Catia Sternini; Fiscal Year: 1990
    ....
  35. Development of Zebrafish Enteric Nervous System and Intestinal Smooth Muscle
    KENNETH WALLACE; Fiscal Year: 2007
    ..Enteric neurons originate from neural crest cells, migrate to the rostral portion of the digestive system, enter the outer mesenchyme, and migrate to the caudal end...
  36. Acting Based Regulation of Smooth Muscle Contraction
    JOSEPH CHALOVICH; Fiscal Year: 2007
    ..lead to new therapies for disorders of smooth muscle including hypertension, asthma, and disorders of the digestive system and urogenital system...
  37. Magnetic tracking for pharmacodynamic studies
    Sankaran Kumar; Fiscal Year: 2001
    ..proposed research will lead to an instrument that will enable gastroenterologists to track objects within the digestive system without using radioactive markers...
  38. CELL BASIS OF DIGESTIVE SYSTEM CHEMICAL MESSENGERS
    MORTON GROSSMAN; Fiscal Year: 1980
    An international symposium on the Cellular Basis of Chemical messengers in the Digestive System will be held on January 17-19, 1980, on the campus of UCLA...
  39. Listeria Monocytogenes to Treat Hepatic Metastases
    Richard Schulick; Fiscal Year: 2009
    ..5 billion. [1] Many cancers such as those originating in the digestive system have a very high propensity to develop hepatic metastases and the primary cause of morbidity and mortality in ..
  40. Zebrafish Lipid Metabolism Assay for Drug Screening
    PETER EIMON; Fiscal Year: 2006
    ..In particular, they process lipids through the digestive system in a manner similar to mammals...
  41. Adaptation of Inquiry-Based Learning Modules For Health Science Literacy
    MARY DERBY; Fiscal Year: 2006
    ..Concepts surrounding digestive system structure and function as well as the role of metabolism will frame the curriculum...
  42. Structure and Affinity: Computing FABP-Lipid Selectivity
    Thomas Woolf; Fiscal Year: 2006
    ..The achievement of this goal would have implications for rational treatment of heart disease and other, e.g. digestive system related, human diseases that involve the control of free fatty acid levels.
  43. Adnesion Receptors of the Insect Immune System
    JAMES NARDI; Fiscal Year: 2003
    ..Understanding the molecular underpinnings of the insect immune response will clearly help in understanding the fate of pathogens in the blood of insect vectors of human diseases. ..
  44. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..
  45. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..Results from this project may contribute to a better understanding of metabolic stimuli that are sensed by the nervous system, and may elucidate neural controls that are involved in obesity, anorexia, and diabetes. ..
  46. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  47. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
  48. BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATION
    JACKIE WOOD; Fiscal Year: 2005
    ..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
  49. PURINERGIC NEUROGENIC MUCOSAL SECRETION
    JACKIE WOOD; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  50. AUTONOMIC CONTROL OF BODY WEIGHT AND FEEDING
    TERRY POWLEY; Fiscal Year: 2006
    ..abstract_text> ..
  51. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    ....
  52. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  53. GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    Catia Sternini; Fiscal Year: 2002
    ..We also plan to characterize GRP receptor recycling and resensitization in cells that normally express GRP receptors: gastric G cells, Swiss 3T3 cells, and small cell lung carcinoma line NCI-H345 cells. ..
  54. PURDUE INTEGRATIVE NEUROSCIENCE PROGRAM
    TERRY POWLEY; Fiscal Year: 2002
    ..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
  55. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  56. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2006
    ..abstract_text> ..
  57. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  58. Chemoprevention of Colonic NOC Formation and Action
    SIDNEY MIRVISH; Fiscal Year: 2006
    ..Overall results will indicate how fecal NOC levels are controlled and can be reduced, and whether fecal NOC can induce colon cancer. [unreadable] [unreadable] [unreadable]..
  59. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..abstract_text> ..
  60. INTEGRATION OF CLINICAL NUTRITION INTO MEDICAL TRAINING
    Nancy Krebs; Fiscal Year: 2004
    ..An evaluation will examine process and impact on learner knowledge, attitudes, and confidence regarding nutrition assessment and counseling. ..