digestive system

Summary

Summary: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).

Top Publications

  1. ncbi Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development
    Lilia Gonzalez-Ceron
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Mexico
    J Med Entomol 40:371-4. 2003
  2. doi Inter- and intraspecific comparison of the bacterial assemblages in the hindgut of humivorous scarab beetle larvae (Pachnoda spp.)
    Janet Andert
    Department of Biogeochemistry, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    FEMS Microbiol Ecol 74:439-49. 2010
  3. pmc Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation
    Yoshitomo Kikuchi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    Appl Environ Microbiol 73:4308-16. 2007
  4. pmc Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
    Janneth Rodrigues
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Science 329:1353-5. 2010
  5. pmc Acetic acid bacteria, newly emerging symbionts of insects
    Elena Crotti
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche DISTAM, Universita degli Studi di Milano, 20133 Milan, Italy
    Appl Environ Microbiol 76:6963-70. 2010
  6. ncbi Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development
    Margaret L Kirby
    Neonatal Perinatal Research Institute, Division of Neonatology, Department of Pediatrics, Box 3179, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 253:175-88. 2003
  7. doi The ultrastructural investigation of the midgut in the quill mite Syringophilopsis fringilla (Acari, Trombidiformes: Syringophilidae)
    S A Filimonova
    Zoological Institute, Parasitology, Russian Academy of Sciences, Universitetskaya embankment 1, 199034 St Petersburg, Russia
    Arthropod Struct Dev 38:303-13. 2009
  8. pmc Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies
    Nagila Secundino
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Cell Microbiol 12:906-18. 2010
  9. ncbi Detection and identification of a novel lactic acid bacterial flora within the honey stomach of the honeybee Apis mellifera
    Tobias C Olofsson
    Microbiology Laboratory at Campus Helsingborg, Department of Cell and Organism Biology, Lund University Campus Helsingborg, P O Box 882, Helsingborg, 25108, Sweden
    Curr Microbiol 57:356-63. 2008
  10. doi Mining an Ostrinia nubilalis midgut expressed sequence tag (EST) library for candidate genes and single nucleotide polymorphisms (SNPs)
    B S Coates
    USDA ARS, Corn Insect and Crop Genetics Research Unit, Genetics Laboratory, Iowa State University, Ames, Iowa 50011, USA
    Insect Mol Biol 17:607-20. 2008

Detail Information

Publications246 found, 100 shown here

  1. ncbi Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development
    Lilia Gonzalez-Ceron
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Mexico
    J Med Entomol 40:371-4. 2003
    ..The overall midgut bacterial infection in mosquito field populations may influence P. vivax transmission, and could contribute to explain the annual variations in malaria incidence observed in the area...
  2. doi Inter- and intraspecific comparison of the bacterial assemblages in the hindgut of humivorous scarab beetle larvae (Pachnoda spp.)
    Janet Andert
    Department of Biogeochemistry, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    FEMS Microbiol Ecol 74:439-49. 2010
    ..A comparison with a previously obtained clone library of the same species corroborates both the similarities and the intraspecific variance of the hindgut microbiota...
  3. pmc Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation
    Yoshitomo Kikuchi
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    Appl Environ Microbiol 73:4308-16. 2007
    ....
  4. pmc Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes
    Janneth Rodrigues
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Science 329:1353-5. 2010
    ..In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory...
  5. pmc Acetic acid bacteria, newly emerging symbionts of insects
    Elena Crotti
    Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche DISTAM, Universita degli Studi di Milano, 20133 Milan, Italy
    Appl Environ Microbiol 76:6963-70. 2010
    ..Taken together, the data indicate that AAB represent novel secondary symbionts of insects...
  6. ncbi Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development
    Margaret L Kirby
    Neonatal Perinatal Research Institute, Division of Neonatology, Department of Pediatrics, Box 3179, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 253:175-88. 2003
    ....
  7. doi The ultrastructural investigation of the midgut in the quill mite Syringophilopsis fringilla (Acari, Trombidiformes: Syringophilidae)
    S A Filimonova
    Zoological Institute, Parasitology, Russian Academy of Sciences, Universitetskaya embankment 1, 199034 St Petersburg, Russia
    Arthropod Struct Dev 38:303-13. 2009
    ..Evacuation of the fecal masses occurs periodically. Mitotic figures have been observed occasionally in the epithelial cells of the anterior midgut...
  8. pmc Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies
    Nagila Secundino
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Cell Microbiol 12:906-18. 2010
    ....
  9. ncbi Detection and identification of a novel lactic acid bacterial flora within the honey stomach of the honeybee Apis mellifera
    Tobias C Olofsson
    Microbiology Laboratory at Campus Helsingborg, Department of Cell and Organism Biology, Lund University Campus Helsingborg, P O Box 882, Helsingborg, 25108, Sweden
    Curr Microbiol 57:356-63. 2008
    ....
  10. doi Mining an Ostrinia nubilalis midgut expressed sequence tag (EST) library for candidate genes and single nucleotide polymorphisms (SNPs)
    B S Coates
    USDA ARS, Corn Insect and Crop Genetics Research Unit, Genetics Laboratory, Iowa State University, Ames, Iowa 50011, USA
    Insect Mol Biol 17:607-20. 2008
    ..This O. nubilalis larval midgut EST collection is a resource for gene discovery, expression information, and allelic variation for use in genetic marker development...
  11. ncbi Commensal host-bacterial relationships in the gut
    L V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Science 292:1115-8. 2001
    ....
  12. ncbi Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues
    Kimberly D Tremblay
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Dev Biol 280:87-99. 2005
    ....
  13. pmc A lipophosphoglycan-independent development of Leishmania in permissive sand flies
    Jitka Myskova
    Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, Prague 2, Czech Republic
    Microbes Infect 9:317-24. 2007
    ..infantum by Lutzomyia longipalpis; this event led to the establishment of L. infantum/chagasi in Latin America...
  14. ncbi Developmental microbial ecology of the neonatal gastrointestinal tract
    R I Mackie
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Am J Clin Nutr 69:1035S-1045S. 1999
    ..Further advances in our understanding of developmental microbial ecology in the neonatal gastrointestinal tract are dependent on the application of these modern molecular techniques...
  15. pmc A simple model host for identifying Gram-positive virulence factors
    D A Garsin
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:10892-7. 2001
    ..We exploit the apparent parallels between Gram-positive infection in simple and more complex organisms by using the nematode to identify an E. faecalis virulence factor, ScrB, which is relevant to mammalian pathogenesis...
  16. pmc Controls on gut phosphatisation: the trilobites from the Weeks Formation Lagerstätte (Cambrian; Utah)
    Rudy Lerosey-Aubril
    Department of Palaeontology and Historical Geology, Senckenberg Research Institute, Frankfurt am Main, Germany
    PLoS ONE 7:e32934. 2012
    ..However, in some specimens from the Weeks Formation, the phosphatisation extends to the entire digestive system, suggesting that trilobites might have had some biological particularities not observed in modern arthropods...
  17. doi Stem cells of the beetle midgut epithelium
    James B Nardi
    Department of Entomology, University of Illinois, 320 Morrill Hall, 505 S Goodwin Avenue, Urbana, IL 61801, United States
    J Insect Physiol 56:296-303. 2010
    ..This organization of stem cell pouches in insect midguts closely parallels that of regenerative crypts in mammalian intestines...
  18. pmc Multilocus microsatellite markers for molecular typing of Candida glabrata: application to analysis of genetic relationships between bloodstream and digestive system isolates
    A Enache-Angoulvant
    AP HP, Hopital Bicetre, Service de Bactériologie Virologie Hygiène, Laboratoire de Parasitologie Mycologie, Kremlin Bicetre, France
    J Clin Microbiol 48:4028-34. 2010
    ..The demonstration of the occurrence of microevolution in digestive strains supports the idea that C. glabrata can be a persistent commensal of the human gut...
  19. ncbi Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
    XuBo Niu
    Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China
    Dev Biol 367:197-207. 2012
    ..Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system.
  20. ncbi Plasmodium falciparum ookinete invasion of the midgut epithelium of Anopheles stephensi is consistent with the Time Bomb model
    L A Baton
    Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Parasitology 129:663-76. 2004
    ....
  21. ncbi Characterization of a membrane-bound aminopeptidase purified from Acyrthosiphon pisum midgut cells. A major binding site for toxic mannose lectins
    Plinio T Cristofoletti
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    FEBS J 273:5574-88. 2006
    ..In addition to oligopeptide digestion, APN is proposed to be associated with amino-acid-absorption processes which, in contrast with aminopeptidase activity, may be hampered on lectin binding...
  22. doi A microarray-based analysis of transcriptional compartmentalization in the alimentary canal of Anopheles gambiae (Diptera: Culicidae) larvae
    M Neira Oviedo
    The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, FL 32080, USA
    Insect Mol Biol 17:61-72. 2008
    ..Furthermore, our data support the notion that the region encompassing the hindgut and Malpighian tubes plays important roles in avoiding the excretion of nutrients, as well as in xenobiotic detoxification...
  23. ncbi Identification of novel Bacillus thuringiensis Cry1Ac binding proteins in Manduca sexta midgut through proteomic analysis
    Rebecca J McNall
    Department of Biochemistry and Molecular Biology, University of Georgia, 413 Biological Sciences Building, 120 Cedar Street, Athens, GA 30602, USA
    Insect Biochem Mol Biol 33:999-1010. 2003
    ..Aminopeptidase N was the only GPI-anchored protein identified. Actin, aminopeptidase N, and membrane alkaline phosphatase were confirmed as accurate protein identifications through western blots...
  24. pmc Proteomic analysis of the mosquito Aedes aegypti midgut brush border membrane vesicles
    Alexandra Popova-Butler
    Department of Biochemistry, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    J Insect Physiol 55:264-72. 2009
    ..Three proteins, arginine kinase, putative allergen and actin are shown to be the most predominant proteins in the sample. The total number of 36 proteins detected by both methods represents the most abundant proteins in the BBMV...
  25. pmc Gut symbiotic bacteria of the genus Burkholderia in the broad-headed bugs Riptortus clavatus and Leptocorisa chinensis (Heteroptera: Alydidae)
    Yoshitomo Kikuchi
    Natural History Laboratory, Faculty of Science, Ibaraki University, Mito 310 8512, Japan
    Appl Environ Microbiol 71:4035-43. 2005
    ..chinensis did not form clades but were intermingled in the phylogeny, suggesting that horizontal transmission of the symbiont might have occasionally occurred between populations and species of the bugs...
  26. ncbi Niche heterogeneity determines bacterial community structure in the termite gut (Reticulitermes santonensis)
    Hong Yang
    Fachbereich Biologie, Mikrobielle Okologie, Universitat Konstanz, 78457 Konstanz, Germany
    Environ Microbiol 7:916-32. 2005
    ....
  27. pmc Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa
    Antonio M Mendes
    Imperial College London, Division of Cell and Molecular Biology, Faculty of Natural Sciences, South Kensington Campus, London, United Kingdom
    PLoS Pathog 4:e1000069. 2008
    ..falciparum field isolates have been established by direct experimentation. Importantly, they validate for semi-field human malaria transmission the concept of parasite antagonists and agonists...
  28. ncbi The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis
    M E Rogers
    Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, UK
    Parasitology 124:495-507. 2002
    ..Collectively, these data support the role of the PSG in the transmission of leishmaniasis, by conditioning the midgut environment for metacyclogenesis and altering the feeding ability of infected sandflies...
  29. ncbi Identification, cloning and expression of a Cry1Ab cadherin receptor from European corn borer, Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae)
    Ronald D Flannagan
    Pioneer Hi Bred International Inc, 7301 NW 62nd Avenue, P O Box 85, Johnston, IA 50131 0085, USA
    Insect Biochem Mol Biol 35:33-40. 2005
    ..1 microg/ml. These results in combination suggest strongly that a cadherin-like protein acts as receptor and is involved with Cry1Ab toxicity in O. nubilalis...
  30. pmc Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice
    T G Schwan
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Clin Microbiol 38:382-8. 2000
    ..Therefore, the temporal synthesis of OspC by spirochetes only in feeding ticks that were infected prior to the blood meal suggests that this surface protein is involved in transmission from tick to mammal but not from mammal to tick...
  31. ncbi Leishmania chagasi: lipophosphoglycan characterization and binding to the midgut of the sand fly vector Lutzomyia longipalpis
    Rodrigo P P Soares
    Laboratory of Medical Entomology, Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima, 1715, 30190 002, Belo Horizonte, MG, Brazil
    Mol Biochem Parasitol 121:213-24. 2002
    ..These results are consistent with the proposal that a New World Leishmania species, similar to Old World species, adapts the expression of terminally exposed sugars of its LPG to mediate parasite-sand fly interactions...
  32. ncbi Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical tr
    Wolfgang A Krueger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen
    Am J Respir Crit Care Med 166:1029-37. 2002
    ..496-1.046). Surveillance cultures from tracheobronchial, oropharyngeal, and gastric secretions and from rectal swabs did not show any evidence for the selection of resistant microorganisms in the patients receiving prophylaxis...
  33. ncbi Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion
    Dina Vlachou
    European Molecular Biology Laboratory, Heidelberg, Germany
    Curr Biol 15:1185-95. 2005
    ..Previously, we have identified hemolymph factors that can antagonize or promote parasite development...
  34. ncbi Digestive lipases: from three-dimensional structure to physiology
    N Miled
    Laboratoire de Lipolyse Enzymatique, CNRS IFR1 UPR 9025, 31, Chemin Joseph Aiguier, 13402 cedex 20, Marseille, France
    Biochimie 82:973-86. 2000
    ..The biochemical, histochemical and clinical studies as well as the 3-D structures obtained will be a great help for a better understanding of the structure-function relationships of digestive lipases...
  35. ncbi Involvement of ghrelin-growth hormone secretagogue receptor system in pathoclinical profiles of digestive system cancer
    Zhigang Wang
    Department of General Surgery, Shanghai Jiaotong University Affiliated No 6 Hospital, Shanghai 200233, China
    Acta Biochim Biophys Sin (Shanghai) 39:992-8. 2007
    ..For the first time, we identified the distribution of ghrelin receptor in digestive system cancers...
  36. ncbi The fine structure of the midgut in the mite Anystis baccarum (L.) (Acari, Actinedida: Anystidae)
    Svetlana A Filimonova
    Zoological Institute, Russian Academy of Sciences, 199034 St Petersburg, Russia
    Arthropod Struct Dev 37:299-309. 2008
    ..All types of secretory granules were observed close to the apical plasmalemma...
  37. doi Morphologic analysis of the zebrafish digestive system
    Andrew J Trotter
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Vic, Australia
    Methods Mol Biol 546:289-315. 2009
    ..Despite optical transparency of embryos, the internal position of the developing digestive system and its close juxtaposition with the yolk initially made morphological analysis relatively challenging, ..
  38. doi Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Westmead, NSW 2145, Australia
    Development 138:4511-22. 2011
    ....
  39. ncbi The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes
    J M Villalon
    Case Western Reserve University, School of Medicine, Department of Genetics, Cleveland, OH 44106, USA
    J Insect Physiol 49:891-5. 2003
    ..PM disruption by two independent means (chitinase and anti-PM antibodies) consistently increases the rate of blood digestion. The significance of these results in relation to PM function is discussed...
  40. pmc Exceptionally preserved Cambrian trilobite digestive system revealed in 3D by synchrotron-radiation X-ray tomographic microscopy
    Mats E Eriksson
    Department of Geology, Lund University, Lund, Sweden
    PLoS ONE 7:e35625. 2012
    ..analogous to the labrum of euarthropods and that it was a sophisticated element closely integrated with the digestive system. This study also briefly addresses the preservational bias of the 'Orsten' fauna, particularly the near-..
  41. doi The effect of peptide absorption on PepT1 gene expression and digestive system hormones in rainbow trout (Oncorhynchus mykiss)
    Teresa Ostaszewska
    Warsaw University of Life Sciences, Division of Ichthyobiology and Fisheries, Faculty of Animal Science, Ciszewskiego 8, 02 786 Warsaw, Poland
    Comp Biochem Physiol A Mol Integr Physiol 155:107-14. 2010
    ..Leptin immunoreactivity was also observed in hepatocyte cytoplasm and pancreatic acinar cells. Gastrin/CCK immunoreactive cells were present in the proximal intestine and pyloric caeca...
  42. pmc Expression of nesfatin-1/NUCB2 in rodent digestive system
    Ai qing Zhang
    Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 16:1735-41. 2010
    To observe the regional distributions and morphological features of nesfatin-1/nucleobindin-2 (NUCB2) immunoreactive (IR) cells in the rodent digestive system.
  43. pmc Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti
    Doug E Brackney
    Arthropod Infectious Disease Laboratory, 1692 Campus Delivery, Department of Microbiology, Immunology and Pathology at Colorado State University, Fort Collins, CO 80523, USA
    J Insect Physiol 56:736-44. 2010
    ..A subfamily of midgut serine proteases and/or that A. aegypti has evolved an array of proteases with a broad range of substrate specificities for rapid, efficient digestion of bloodmeals...
  44. pmc Indirect effects of temperature on stink bug fitness, via maintenance of gut-associated symbionts
    Simone S Prado
    Empresa Brasileira de Pesquisa Agropecuaria, Londrina, PR, Brazil
    Appl Environ Microbiol 76:1261-6. 2010
    ..This work illustrates the need to better understand the biology of animal-symbiont associations and the consequences of local climate for the dynamics of these interactions...
  45. doi Ultrastructural changes of the midgut epithelium in Isohypsibius granulifer granulifer Thulin, 1928 (Tardigrada: Eutardigrada) during oogenesis
    Magdalena M Rost-Roszkowska
    Department of Animal Histology and Embryology, University of Silesia, Bankowa 9, 40 007, Katowice, Poland
    Protoplasma 248:405-14. 2011
    ..At the end of oogenesis, autophagy also intensifies in midgut epithelial cells, which is probably caused by the great amount of reserve material. Midgut epithelium of analyzed species takes part in the yolk precursor synthesis...
  46. ncbi Uptake, flow, and digestion of casein and green fluorescent protein in the digestive system of Lygus hesperus Knight
    Javad Habibi
    Department of Entomology, University of Missouri, Columbia, USA
    Arch Insect Biochem Physiol 50:62-74. 2002
    ..Dextran was used as a control to monitor the non-absorptive flow rate of ingesta through the digestive system. Fluorescent tracking of FITC-conjugates of casein and dextran, as well as immunoblotting and ..
  47. ncbi Fine structure of the midgut epithelium in two Archaeognatha, Lepismachilis notata and Machilis hrabei (Insecta), in relation to its degeneration and regeneration
    Magdalena M Rost-Roszkowska
    Department of Animal Histology and Embryology, University of Silesia, Bankowa 9, Katowice, Poland
    Protoplasma 247:91-101. 2010
    ..Some of them proliferate, while the others differentiate into epithelial cells. We compared the organisation of the midgut epithelium of M. hrabei and L. notata with zygentoman species, which have just been described...
  48. ncbi Vertebrate endoderm development
    J M Wells
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Cell Dev Biol 15:393-410. 1999
    ..We discuss possible mechanisms that regulate how undifferentiated endoderm becomes specified into a myriad of cell types that populate the respiratory and gastrointestinal tracts...
  49. ncbi Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study
    D C Bergmans
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 164:382-8. 2001
    ..cross infection, prevention and control; respiration, artificial, adverse effects; antibiotics, administration and dosage infection control methods; pneumonia, etiology, prevention and control; intubation, intratracheal, adverse effects..
  50. ncbi Microscopic anatomy of pycnogonida: II. Digestive system. III. Excretory system
    W H Fahrenbach
    Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Morphol 268:917-35. 2007
    The digestive system of several species of sea spiders (Pycnogonida, Arthropoda) was studied by electron microscopy. It is composed of the foregut inside a long proboscis, a midgut and a hindgut...
  51. pmc Hypothermia does not increase the risk of infection: a case control study
    Marlijn Kamps
    Department of Intensive Care, Radboud University Nijmegen Medical Centre PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Crit Care 15:R48. 2011
    ..The aim of this study was to investigate the incidence of infections in patients treated with hypothermia and normothermia while receiving SDD...
  52. ncbi Histological and ultrastructural characterization of the alimentary system of solifuges (Arachnida, Solifugae)
    A E Klann
    Ernst Moritz Arndt Universitat Greifswald, Zoologisches Institut and Museum, Johann Sebastian Bach Strabetae 11 12, 17487 Greifswald, Germany
    J Morphol 271:225-43. 2010
    ..In contrast to the midgut, the epithelium of the hindgut consists of only one type of cell overlain by a thin cuticle. Digested residuals are stored in the hindgut until defecation...
  53. ncbi Interaction of two Bacillus thuringiensis delta-endotoxins with the digestive system of Lygus hesperus
    Sandra L Brandt
    Biological Control of Insects Research Laboratory, US Department of Agriculture, Agricultural Research Service, 1503 S Providence Rd, Columbia, MO 65203, USA
    Curr Microbiol 48:1-9. 2004
    ..Proteolytic processing of the toxins also occurred in vivo, within the digestive system of L. hesperus. Excreted CrylAc and Cry2Ab retained activity toward lepidopteran larvae...
  54. ncbi Effects of 17beta-estradiol on mussel digestive gland
    Laura Canesi
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Gen Comp Endocrinol 153:40-6. 2007
    ....
  55. doi Organogenesis in the budding process of the freshwater bryozoan Cristatella mucedo Cuvier, 1798 (Bryozoa, Phylactolaemata)
    Thomas Schwaha
    Department of Theoretical Biology, Morphology Section, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
    J Morphol 272:320-41. 2011
    ..Nonetheless, our results show that comparative organogenesis can contribute to phylactolaemate systematics and, when more data are available, possibly to that of other bryozoan classes and bilaterian phyla...
  56. ncbi Characterization of proteases in the digestive system of spiny lobster (Panulirus interruptus)
    Laura E Celis-Guerrero
    Centro de Investigaciones Biologicas del Noroeste CIBNOR, PO Box 129, La Paz, B C S 23000, Mexico
    Mar Biotechnol (NY) 6:262-9. 2004
    ..Also, such enzymes become alternative tools for use in biotechnologies...
  57. ncbi Metal accumulation and binding protein induction in Mytilus galloprovincialis, Scapharca inaequivalvis, and Tapes philippinarum from the Lagoon of Venice
    P Irato
    Department of Biology, University of Padova, Italy
    Arch Environ Contam Toxicol 44:476-84. 2003
    ..inaequivalvis are sentinel organisms and can be used specifically for Zn pollution; (3) T. philippinarum accumulates Cu in the digestive gland more readily than the other two bivalves and therefore has the highest MT...
  58. ncbi Ultrastructure of the midgut and hindgut of Derocheilocaris remanei (Crustacea, Mystacocarida)
    L Herrera-Alvarez
    Departamento de Biología Animal I, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    J Morphol 244:177-89. 2000
    ..A single basic cell type forms the hindgut epithelium. The suggested function for the hindgut is the transport and ejection of waste products...
  59. ncbi Endogenous beta-galactosidase activity in amphioxus: a useful histochemical marker for the digestive system
    C Canestro
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 645 Av Diagonal, 08028 Barcelona, Spain
    Dev Genes Evol 211:154-6. 2001
    ..of beta-galactosidase activity was used to monitor morphological and functional differentiation of the digestive system and the posteriorization of the endodermal structures in retinoic-acid treated embryos...
  60. doi Effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in the digestive system of tilapia (Oreochromis niloticus)
    Wei Dai
    Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, Zhejiang University, Hangzhou, 310029, People s Republic of China
    Biol Trace Elem Res 127:124-31. 2009
    ..the effects of dietary Pb on accumulation, histopathology, and digestive enzyme activities in tissues of the digestive system. The results showed that the Pb accumulation in tissues increased with the dietary Pb concentrations...
  61. ncbi Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland
    Laura Canesi
    Dipartimento di Biologia, Universita di Genova, Corso Europa 26, 16132 Genova, Italy
    Aquat Toxicol 87:272-9. 2008
    ..The results demonstrate that short-term exposure to environmentally relevant concentrations of EDC mixtures can interfere with the lysosomal function, redox-related enzyme activities and gene transcription of mussel digestive gland...
  62. ncbi Cellular expression of gut chitinase mRNA in the gastrointestinal tract of mice and chickens
    Masako Suzuki
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan
    J Histochem Cytochem 50:1081-9. 2002
    ....
  63. ncbi Effects of vibrio challenge on digestive gland biomarkers and antioxidant gene expression in Mytilus galloprovincialis
    Laura Canesi
    Dipartimento di Biologia, Universita di Genova, Italy
    Comp Biochem Physiol C Toxicol Pharmacol 152:399-406. 2010
    ..Moreover, the results support the hypothesis that host responses to bacteria may be taken into account when interpreting biomarker data in ecotoxicological studies...
  64. ncbi Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, New South Wales 2145, Australia
    Development 134:251-60. 2007
    ..The observation that the endoderm cells are inherently unable to move despite the expansion of the mesoderm in the Mixl1-null mutant suggests that the movement of the endoderm and the mesoderm is driven independently of one another...
  65. ncbi Aquaporins in the digestive system
    Toshiyuki Matsuzaki
    Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Med Electron Microsc 37:71-80. 2004
    Fluid transfer such as secretion and absorption is one of the major functions of the digestive system. Aquaporins are water channel proteins providing water transfer across the cellular membrane...
  66. ncbi Can bacterial interference prevent infection?
    G Reid
    Lawson Health Research Institute, University of Western Ontario, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
    Trends Microbiol 9:424-8. 2001
    ..The potential for new therapeutic regimens using probiotics is significant and worthy of further study...
  67. ncbi Nil per os encodes a conserved RNA recognition motif protein required for morphogenesis and cytodifferentiation of digestive organs in zebrafish
    Alan N Mayer
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Development 130:3917-28. 2003
    ..Antisense-mediated knockdown of npo results in organ hypoplasia, and overexpression of npo causes an overgrowth of gastrointestinal organs. Thus, npo is a gene essential for a key step in the gut morphogenetic sequence...
  68. pmc The Anopheles gambiae adult midgut peritrophic matrix proteome
    R R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Insect Biochem Mol Biol 39:125-34. 2009
    ..Among them were nine new chitin-binding peritrophic matrix proteins, expanding the list from three to twelve peritrophins. Lastly, we provide a model for the putative interactions among the proteins identified in this study...
  69. ncbi Studies on cultured and uncultured microbiota of wild culex quinquefasciatus mosquito midgut based on 16s ribosomal RNA gene analysis
    Vyankatesh J Pidiyar
    Molecular Biology Unit, National Centre for Cell Science, University of Pune, Pune, India
    Am J Trop Med Hyg 70:597-603. 2004
    ....
  70. ncbi Gene expression patterns of Helicoverpa armigera gut proteases
    Nanasaheb P Chougule
    National Chemical Laboratory, Plant Molecular Biology Unit, Division of Biochemical Sciences, Dr Homi Bhabha Road, Pune 411 008 MS, India
    Insect Biochem Mol Biol 35:355-67. 2005
    ..The proteases identified in the study would be ideal candidates for further interactions studies with protease inhibitors to understand the structural reasons of protease inhibitor insensitivity...
  71. ncbi Peritrophic matrix proteins
    R L Tellam
    CSIRO Tropical Agriculture, Queensland, Australia
    Insect Biochem Mol Biol 29:87-101. 1999
    ..The review concludes with speculation about the biological functions of the proteins in this matrix...
  72. pmc Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:15882-7. 2007
    ..We provide evidence for the in vivo role of chondroitin sulfate proteoglycans in Plasmodium falciparum invasion of the midgut and insight into the molecular mechanisms mediating parasite-mosquito interactions...
  73. ncbi Bacterial resistance and overgrowth due to selective decontamination of the digestive tract
    W Ebner
    Institute of Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Germany
    Eur J Clin Microbiol Infect Dis 19:243-7. 2000
    ..To date, none of the studies available for examination have been designed to adequately assess the effect of selective decontamination of the digestive tract on the bacterial flora...
  74. doi A comparative molecular study of the presence of "Candidatus arthromitus" in the digestive system of rainbow trout, Oncorhynchus mykiss (Walbaum), healthy and affected with rainbow trout gastroenteritis
    J Del-Pozo
    Department of Veterinary Pathology, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    J Fish Dis 33:241-50. 2010
    ..The results of this study showed that the presence of SFB was not invariably associated with clinical disease and that more information is required to understand the role of these organisms...
  75. ncbi Meconial peritrophic membranes and the fate of midgut bacteria during mosquito (Diptera: Culicidae) metamorphosis
    R M Moll
    Department of Biomedical Sciences, Tropical Disease Institute, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
    J Med Entomol 38:29-32. 2001
    ....
  76. pmc A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
    D Ferrandon
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, 15, rue René Descartes, F67084 Strasbourg, France
    EMBO J 17:1217-27. 1998
    ..We also show that, in contrast to the systemic antifungal response, this local immune response is independent of the Toll pathway...
  77. ncbi The surface protein Pvs25 of Plasmodium vivax ookinetes interacts with calreticulin on the midgut apical surface of the malaria vector Anopheles albimanus
    Maria del Carmen Rodriguez
    Centro De Investigacion sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Mol Biochem Parasitol 153:167-77. 2007
    ..The Pvs25-calreticulin interaction in vivo could represent a potential target for developing transmission blocking strategies based on interfering the parasite-midgut interaction...
  78. doi Contribution of gut bacteria to digestion and development of the velvetbean caterpillar, Anticarsia gemmatalis
    L E Visôtto
    Departamento de Bioquimica e Biologia Molecular, Instituto de Biotecnologia Aplicada à Agropecuária BIOAGRO, Universidade Federal de Vicosa, Vicosa, MG 36571 000, Brazil
    J Insect Physiol 55:185-91. 2009
    ....
  79. doi Regulatory peptides in fruit fly midgut
    Jan A Veenstra
    CNIC UMR 5228 CNRS, Universite Bordeaux 1, 33400, Talence, France
    Cell Tissue Res 334:499-516. 2008
    ..Although the Drosophila insulin gene Ilp3 was abundantly expressed in the midgut, Ilp3 was not expressed in endocrine cells, but in midgut muscle...
  80. ncbi Formation of the digestive system in zebrafish. I. Liver morphogenesis
    Holly A Field
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:279-90. 2003
    Despite the essential functions of the digestive system, much remains to be learned about the cellular and molecular mechanisms responsible for digestive organ morphogenesis and patterning...
  81. pmc Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:2521-31. 2007
    ..These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach...
  82. ncbi Real-time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion
    Dina Vlachou
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell Microbiol 6:671-85. 2004
    ..Similar observations were made in both A. gambiae and A. stephensi, demonstrating the conservation of P. berghei interactions with these vectors...
  83. pmc Essential role of membrane-attack protein in malarial transmission to mosquito host
    Kimie Kadota
    Mie University School of Medicine, Mie 514 0001, Japan
    Proc Natl Acad Sci U S A 101:16310-5. 2004
    ....
  84. ncbi Storage and secretion of the peritrophic matrix protein Ag-Aper1 and trypsin in the midgut of Anopheles gambiae
    M Devenport
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Insect Mol Biol 13:349-58. 2004
    ..Newly synthesized Ag-Aper1 protein was again detected within the midgut epithelial cells at 60 h after blood ingestion...
  85. doi The movement of proteins across the insect and tick digestive system
    Laura A Jeffers
    Department of Entomology, Dearstyne Entomology Building, North Carolina State University, Raleigh, NC 27695 7647, USA
    J Insect Physiol 54:319-32. 2008
    The movement of intact proteins across the digestive system was shown in a number of different blood-feeding and non-blood-feeding insects in the orders Blattaria, Coleoptera, Diptera, Hemiptera, Lepidoptera, Orthoptera, Neuroptera and ..
  86. pmc Sex-specific and blood meal-induced proteins of Anopheles gambiae midguts: analysis by two-dimensional gel electrophoresis
    G I Prévot
    Ecologie des Systèmes Vectoriels, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex15, France
    Malar J 2:1. 2003
    ..Characterisation of An. gambiae midgut proteins may identify the proteins that render An. gambiae receptive to the malaria parasite...
  87. pmc Insulin regulates aging and oxidative stress in Anopheles stephensi
    Mi Ae Kang
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 211:741-8. 2008
    ....
  88. ncbi Cowpea bruchid Callosobruchus maculatus counteracts dietary protease inhibitors by modulating propeptides of major digestive enzymes
    J E Ahn
    Department of Entomology, Texas A and M University, College Station, Texas 77843, USA
    Insect Mol Biol 16:295-304. 2007
    ....
  89. pmc A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system
    Pei wen Pan
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520, Tampere, Finland
    BMC Mol Biol 8:22. 2007
    ..In the present study, we systematically examined the mRNA expression levels of all known CA isozymes by quantitative real-time PCR in eight tissues of the digestive system of male and female mice.
  90. ncbi Anatomical and functional characterisation of the stomatogastric nervous system of blowfly (Calliphora vicina) larvae
    Andreas Schoofs
    Institut fur Zoologie, Abteilung Neurobiologie, Universitat Bonn, Poppelsdorfer Schloss, 53115 Bonn, Germany
    J Insect Physiol 53:349-60. 2007
    ..The dorsal organs (DOs) are directly connected to the SNS. Mechanical stimulation of the DOs evokes sensory activity in the AN. This suggests the DOs can provide sensory input for temporal coordination of feeding behaviour...
  91. ncbi Lutzomyia longipalpis peritrophic matrix: formation, structure, and chemical composition
    N F C Secundino
    Laboratory of Medical Entomology Centro de Pesquisas René Rachou, Fundacao Oswaldo Cruz, Minas Gerais, Brazil
    J Med Entomol 42:928-38. 2005
    ..7-135 kDa, induced by the protein-free diet. Mouse polyclonal antiserum was produced against PMs induced by protein-free meal and used in Western blotting, which revealed at least three associated proteins...
  92. pmc Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei
    Mónica González-Lázaro
    Department of Cell Biology, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico City, Mexico
    Insect Biochem Mol Biol 39:395-402. 2009
    ..Interestingly, knockdown of SCRBQ2 expression by dsRNA injection resulted in a 62.5% inhibition of oocyst formation, suggesting that SCRBQ2 plays a role in Plasmodium-mosquito interactions...
  93. ncbi Digestive system of the sacoglossan Plakobranchus ocellatus (Gastropoda: Opisthobranchia): light- and electron-microscopic observations with remarks on chloroplast retention
    Euichi Hirose
    Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
    Zoolog Sci 22:905-16. 2005
    ..Morphology of the entire digestive system of this species was firstly described by means of a combination of histology and electron microscopy (both ..
  94. pmc FMRFamide-like immunoreactivity in the central nervous system and alimentary tract of the non-hematophagous blow fly, Phormia regina, and the hematophagous horse fly, Tabanus nigrovittatus
    Aaron T Haselton
    Department of Biology, State University of New York at New Paltz, New Paltz, NY, USA
    J Insect Sci 8:1-17. 2008
    ....
  95. ncbi Analysis of midgut proteinases from Bacillus thuringiensis-susceptible and -resistant Heliothis virescens (Lepidoptera: Noctuidae)
    Lohitash Karumbaiah
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Comp Biochem Physiol B Biochem Mol Biol 146:139-46. 2007
    ..Because serine proteinases are a critical component of Bt toxin mode of action, these differences may contribute to decreased toxicity in the Bt-resistant strains...
  96. ncbi Cloning and characterization of trypsin- and chymotrypsin-like proteases from the midgut of the sand fly vector Phlebotomus papatasi
    J M Ramalho-Ortigão
    Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 4 Center Drive, Building 4, Room 126, MSC 0425, NIH, Bethesda, MD 20892 0425, USA
    Insect Biochem Mol Biol 33:163-71. 2003
    ..The two chymotrypsin-like enzymes display expression behavior similar to that of the early and late trypsins from Ae. aegypti...
  97. ncbi A new approach reveals syncytia within the visceral musculature of Drosophila melanogaster
    R Klapper
    Institut für Allgemeine Zoologie und Genetik der Westfälischen Wilhelms Universität, Schlossplatz 5, 48149 Munster, Germany
    Development 128:2517-24. 2001
    ..This novel application of the transplantation technique might be a powerful tool to trace syncytia in any organism using the GAL4/UAS system...
  98. ncbi SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development
    Johannes T Dessens
    Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, SW7 2AZ, UK
    Mol Microbiol 49:319-29. 2003
    ..These results identify SOAP as a key molecule for ookinete-to-oocyst differentiation in mosquitoes...
  99. ncbi The formation of syncytia within the visceral musculature of the Drosophila midgut is dependent on duf, sns and mbc
    Robert Klapper
    Institut für Allgemeine Zoologie und Genetik der Westfälischen Wilhelms Universität, Schlossplatz 5, 48149 Munster, Germany
    Mech Dev 110:85-96. 2002
    ..Our results provide strong evidence that the founder-cell hypothesis also applies to visceral myogenesis, employing the same genetic components as are used in the somatic myoblast fusion processes...
  100. ncbi Immunolocalization of the water channel, aquaporin-5 (AQP5), in the rat digestive system
    Toshiyuki Matsuzaki
    Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Arch Histol Cytol 66:307-15. 2003
    ..We surveyed the expression and immunohistochemical localization of AQP5 in the rat digestive system. RT-PCR analysis revealed that AQP5 is expressed in the submandibular gland, tongue, gastric corpus, pyloric ..
  101. ncbi Absorption and tissue distribution of cholesterol in Manduca sexta
    Zeina E Jouni
    Department of Biochemistry and Molecular Biophysics, Center of Insect Science, Biological Sciences West, University of Arizona, Tucson, 85721 0088, USA
    Arch Insect Biochem Physiol 49:167-75. 2002
    ..Cholesterol-labeled lipophorin injected into larval hemolymph was cleared from the hemolymph with a half-life of 10.2 h. After 17 h, most of the cleared radioactivity was recovered in the fat body (38%). Arch...

Research Grants78

  1. REGULATION OF DIGESTION IN BLOOD-SUCKING INSECTS
    Michael Wells; Fiscal Year: 1992
    ..A. aegypti uses a trypsin-based digestive system, whereas R. prolixus uses a cathepsin-based digestive system. In A...
  2. REGULATION OF DIGESTION IN BLOOD-SUCKING INSECTS
    Michael Wells; Fiscal Year: 1993
    ..A. aegypti uses a trypsin-based digestive system, whereas R. prolixus uses a cathepsin-based digestive system. In A...
  3. Implantation of physiologically functional bioengineered innervated IAS construct
    KHALIL BITAR; Fiscal Year: 2009
    ..by applicant): Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
  4. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..by applicant): Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
  5. STRUCTURE AND ROLE(S) OF GASTRIC AND THYMIC PEPTIDES
    Robert Carraway; Fiscal Year: 1980
    ..and immunohistochemistry we have detected NT-related activity throughout the central nervous system (CNS) and digestive system of the rat, as well as in the chicken and rat thymus gland...
  6. Spatiotemporal Regulation of Intestinal Gene Expression
    Eric Sibley; Fiscal Year: 2010
    Lactase non-persistence (adult-type hypolactasia) results in digestive system malabsorption of lactose, the carbohydrate macronutrient present in milk...
  7. Spatiotemporal Regulation of Intestinal Gene Expression
    Eric Sibley; Fiscal Year: 2009
    Lactase non-persistence (adult-type hypolactasia) results in digestive system malabsorption of lactose, the carbohydrate macronutrient present in milk...
  8. Spatiotemporal Regulation of Intestinal Gene Expression
    Eric Sibley; Fiscal Year: 2010
    Lactase non-persistence (adult-type hypolactasia) results in digestive system malabsorption of lactose, the carbohydrate macronutrient present in milk...
  9. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..11) Regenerative Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
  10. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    Joseph Bonventre; Fiscal Year: 2009
    ..11) Regenerative Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
  11. THE MECHANISM OF STARCH DIGESTION IN MAMMALS
    William Whelan; Fiscal Year: 1980
    ..has as its basic aim the elucidation of the mechanisms whereby starch is broken down to glucose in the digestive system of mammals...
  12. Functional Brain Imaging and Appetite-Related Hormones Pre and Post Obesity Surge
    Allan Geliebter; Fiscal Year: 2009
    ..Changes in brain responses to food stimuli as well as changes in appetite hormones produced by the digestive system will be assessed following two types of obesity surgery: 1) gastric bypass and 2) gastric banding...
  13. Functional Brain Imaging and Appetite-Related Hormones Pre and Post Obesity Surge
    Allan Geliebter; Fiscal Year: 2010
    ..Changes in brain responses to food stimuli as well as changes in appetite hormones produced by the digestive system will be assessed following two types of obesity surgery: 1) gastric bypass and 2) gastric banding...
  14. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..Homeostasis in the digestive system is also maintained in part by chemical sensors present on different subtypes of enteroendocrine cells...
  15. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2010
    ..Homeostasis in the digestive system is also maintained in part by chemical sensors present on different subtypes of enteroendocrine cells...
  16. FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATION
    M Omary; Fiscal Year: 2001
    ..Our proposed studies are likely to generate important new biologic information regarding two major protein families in the digestive system, and help clarify their function and potential role in human disease.
  17. FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATION
    M Omary; Fiscal Year: 2000
    ..Our proposed studies are likely to generate important new biologic information regarding two major protein families in the digestive system, and help clarify their function and potential role in human disease.
  18. FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATION
    M Omary; Fiscal Year: 1999
    ..Our proposed studies are likely to generate important new biologic information regarding two major protein families in the digestive system, and help clarify their function and potential role in human disease.
  19. Expression of Human Therapeutic Proteins in Transgenic Tobacco Chloroplasts
    Henry Daniell; Fiscal Year: 2010
    ..of therapeutic proteins expressed in plant cells offers several advantages including protection in the digestive system by bioencapsulation, followed by slow release in the gut;elimination of expensive purification steps, the ..
  20. Expression of Human Therapeutic Proteins in Transgenic Tobacco Chloroplasts
    Henry Daniell; Fiscal Year: 2009
    ..of therapeutic proteins expressed in plant cells offers several advantages including protection in the digestive system by bioencapsulation, followed by slow release in the gut;elimination of expensive purification steps, the ..
  21. Expression of Human Therapeutic Proteins in Transgenic Tobacco Chloroplasts
    Henry Daniell; Fiscal Year: 2006
    ..of therapeutic proteins expressed in plant cells offers several advantages including protection in the digestive system by bioencapsulation, followed by slow release in the gut; elimination of expensive purification steps, the ..
  22. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..Area - (11) Regenerative Medicine Specific challenge topic - 11-DK-101 Promote regeneration and repair in the digestive system, liver, pancrease, kidneys, hematologic, and urological system. 3...
  23. The role of Wnt signaling in the development of the veterbrate visceral mesoderm
    Valerie McLin; Fiscal Year: 2007
    ..Developmental biology of the digestive system aims to further the understanding of both congenital and acquired forms of pediatric gastrointestinal disease ..
  24. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2004
    ..are expected to provide valuable new information on both the stimulatory effects of food on the human digestive system and the nutritional value of modern nutritional support techniques, and help determine why elemental diets ..
  25. Characterization of a mutation that affects feeding and digestion in Drosophila
    EDWARD BLUMENTHAL; Fiscal Year: 2009
    ..In focusing on a mutation in the fruit fly Drosophila that affects digestion and feeding behavior, this project will provide insight into the function of the human digestive system and its role in appetite control.
  26. Characterization of a mutation that affects feeding and digestion in Drosophila
    EDWARD BLUMENTHAL; Fiscal Year: 2007
    ..a mutation in the fruit fly Drosophila that affects digestion and feeding behavior, this project will provide insight into the function of the human digestive system and its role in appetite control. [unreadable] [unreadable] [unreadable]
  27. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2002
    ..are expected to provide valuable new information on both the stimulatory effects of food on the human digestive system and the nutritional value of modern nutritional support techniques, and help determine why elemental diets ..
  28. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2002
    ..are expected to provide valuable new information on both the stimulatory effects of food on the human digestive system and the nutritional value of modern nutritional support techniques, and help determine why elemental diets ..
  29. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2000
    ..are expected to provide valuable new information on both the stimulatory effects of food on the human digestive system and the nutritional value of modern nutritional support techniques, and help determine why elemental diets ..
  30. DIET, DISEASE, AND PANCREATIC ENZYME SYNTHESIS IN HUMANS
    STEPHEN O KEEFE; Fiscal Year: 2001
    ..are expected to provide valuable new information on both the stimulatory effects of food on the human digestive system and the nutritional value of modern nutritional support techniques, and help determine why elemental diets ..
  31. Genetics of Taste Perception
    Alexander Bachmanov; Fiscal Year: 2009
    ..Taste also influences food processing by the digestive system. Consequently, understanding the mechanisms underlying this sense is central to our ability to control intake ..
  32. Genetics of Taste Perception
    Alexander Bachmanov; Fiscal Year: 2009
    ..Taste also influences food processing by the digestive system. Consequently, understanding the mechanisms underlying this sense is central to our ability to control intake ..
  33. Genetics of Taste Perception
    Alexander A Bachmanov; Fiscal Year: 2010
    ..Taste also influences food processing by the digestive system. Consequently, understanding the mechanisms underlying this sense is central to our ability to control intake ..
  34. DUKE/NIDDK FUNCTIONAL GENOMICS CENTER
    Joseph Nevins; Fiscal Year: 2002
    ..specialized DNA microarrays, that will specifically and uniquely enhance studies directed at the kidney and digestive system. This will be accomplished by generating cDNA and SAGE libraries so as to identify expressed sequences that ..
  35. DUKE/NIDDK FUNCTIONAL GENOMICS CENTER
    Joseph Nevins; Fiscal Year: 2000
    ..specialized DNA microarrays, that will specifically and uniquely enhance studies directed at the kidney and digestive system. This will be accomplished by generating cDNA and SAGE libraries so as to identify expressed sequences that ..
  36. DUKE/NIDDK FUNCTIONAL GENOMICS CENTER
    Joseph Nevins; Fiscal Year: 2001
    ..specialized DNA microarrays, that will specifically and uniquely enhance studies directed at the kidney and digestive system. This will be accomplished by generating cDNA and SAGE libraries so as to identify expressed sequences that ..
  37. Targeting Myofibroblast for Intestinal Epithelial Regeneration
    Hongmiao Sheng; Fiscal Year: 2009
    ..11) Regenerative Medicine and Specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, Hematologic, and urological system...
  38. Formation of the Enteric Nervous System
    Chen Ming Fan; Fiscal Year: 2010
    ..They control the movement, secretion, and absorption of the digestive system. Deficiency of enteric neurons causes abdominal distention and constipation, a condition of patients ..
  39. Targeting Myofibroblast for Intestinal Epithelial Regeneration
    Hongmiao Sheng; Fiscal Year: 2010
    ..11) Regenerative Medicine and Specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, Hematologic, and urological system...
  40. NUTRIENT INFUSION FOR ENZYME SYNTHESIS IN PANCRCREATITIS
    STEPHEN O KEEFE; Fiscal Year: 2000
    The measurement of the use of specialized feeding techniques by the digestive system with the aim of developing the best way of feeding patients with digestive diseases such as acute pancreatitis...
  41. Neural Circuitry in the Caudal Solitary Complex
    Bret Smith; Fiscal Year: 2004
    ..fibers of the vagus nerve from the digestive tract, neurons in the nucleus tractus solitarius (NTS) process digestive system information prior to further integration via higher brain areas and eventual activation of motor output to ..
  42. NOVEL ENZYME/PRODRUG STRATEGY FOR CANCER GENE THERAPY
    Alnawaz Rehemtulla; Fiscal Year: 1999
    ..Since CPA is normally secreted from cells as a zymogen and requires cleavage by trypsin in the digestive system for functional activation, the applicants will generate CPA forms that can be expressed in mammalian cells as ..
  43. NOVEL ENZYME/PRODRUG STRATEGY FOR CANCER GENE THERAPY
    Alnawaz Rehemtulla; Fiscal Year: 2001
    ..Since CPA is normally secreted from cells as a zymogen and requires cleavage by trypsin in the digestive system for functional activation, the applicants will generate CPA forms that can be expressed in mammalian cells as ..
  44. NOVEL ENZYME/PRODRUG STRATEGY FOR CANCER GENE THERAPY
    Alnawaz Rehemtulla; Fiscal Year: 2000
    ..Since CPA is normally secreted from cells as a zymogen and requires cleavage by trypsin in the digestive system for functional activation, the applicants will generate CPA forms that can be expressed in mammalian cells as ..
  45. NEUROPEPTIDE REGULATION OF ENTEROPANCREATIC FUNCTION
    Michael Mulholland; Fiscal Year: 1991
    Until recent years it was believed that the functions of the digestive system were controlled by the two classical divisions of the autonomic nervous system acting in concert with established gastrointestinal hormones...
  46. NEUROPEPTIDE REGULATION OF ENTEROPANCREATIC FUNCTION
    Michael Mulholland; Fiscal Year: 1993
    Until recent years it was believed that the functions of the digestive system were controlled by the two classical divisions of the autonomic nervous system acting in concert with established gastrointestinal hormones...
  47. NEUROPEPTIDE REGULATION OF ENTEROPANCREATIC FUNCTION
    Michael Mulholland; Fiscal Year: 1992
    Until recent years it was believed that the functions of the digestive system were controlled by the two classical divisions of the autonomic nervous system acting in concert with established gastrointestinal hormones...
  48. HORMONES AND THE PROGRAMMED DEATH IN PETROMYZON MARINUS
    AUGUST EPPLE; Fiscal Year: 1980
    ..endocrines and neurosecretions, (b) degenerative changes in the central nervous system, (c) atrophies in the digestive system, (d) kidney regression, (e) vascular pathologies; (3) autoradiography of steroid hormone and thyroxin target ..
  49. Epidemiology of Celiac Disease: A Population Based Study
    Joseph A Murray; Fiscal Year: 2010
    Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  50. Epidemiology of Celiac Disease: A Population Based Study
    Joseph Murray; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  51. SENSORY AFFERENT INNERVATION OF THE DIGESTIVE SYSTEM
    Catia Sternini; Fiscal Year: 1990
    ....
  52. Epidemiology of Celiac Disease: A Population Based Study
    Joseph A Murray; Fiscal Year: 2010
    Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  53. Epidemiology of Celiac Disease: A Population Based Study
    Joseph Murray; Fiscal Year: 2009
    Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  54. Epidemiology of Celiac Disease: A Population Based Study
    Joseph Murray; Fiscal Year: 2009
    Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  55. Epidemiology of Celiac Disease: A Population Based Study
    Joseph Murray; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Celiac disease (CD) is one of the most common chronic diseases of the digestive system, and is readily treatable with exclusion of dietary gluten...
  56. Fate Mapping and Analysis of the Definitive Endoderm
    Kimberly Tremblay; Fiscal Year: 2005
    ..Together these studies will provide for a more thorough understanding of the processes leading to the formation of a normal digestive system, allowing for the advancement of therapies for the diseased state.
  57. Fate Mapping and Analysis of the Definitive Endoderm
    Kimberly Tremblay; Fiscal Year: 2004
    ..Together these studies will provide for a more thorough understanding of the processes leading to the formation of a normal digestive system, allowing for the advancement of therapies for the diseased state.
  58. Fate Mapping and Analysis of the Definitive Endoderm
    Kimberly Tremblay; Fiscal Year: 2003
    ..Together these studies will provide for a more thorough understanding of the processes leading to the formation of a normal digestive system, allowing for the advancement of therapies for the diseased state.
  59. Fate Mapping and Analysis of the Definitive Endoderm
    Kimberly Tremblay; Fiscal Year: 2005
    ..Together these studies will provide for a more thorough understanding of the processes leading to the formation of a normal digestive system, allowing for the advancement of therapies for the diseased state.
  60. Fate Mapping and Analysis of the Definitive Endoderm
    Kimberly Tremblay; Fiscal Year: 2004
    ..Together these studies will provide for a more thorough understanding of the processes leading to the formation of a normal digestive system, allowing for the advancement of therapies for the diseased state.
  61. Mechanisms of alimentary chemosensation
    Steven D Munger; Fiscal Year: 2010
    ..In Aim 2, we will characterize the role of two hormones expressed in taste cells and in the digestive system, glucagon-like peptide-1 (GLP-1) and glucagon, in the modulation of taste sensitivity...
  62. Regulation of Digestive Vesicular Glutamate Transporter
    Liqun Bai; Fiscal Year: 2003
    ..The long-term goal of our laboratory is to study the regulation of vesicular glutamate transporter in digestive system. The primary purpose of this proposal is to determine the mechanisms of glucose-induced regulation of ..
  63. Regulation and Dynamics of Keratins in Digestive Organs
    M Omary; Fiscal Year: 2005
    ..Our proposed studies are likely to generate important new biologic information regarding keratins in the digestive system, and to help clarify their function and role in human disease.
  64. Regulation and Dynamics of Keratins in Digestive Organs
    M Omary; Fiscal Year: 2004
    ..Our proposed studies are likely to generate important new biologic information regarding keratins in the digestive system, and to help clarify their function and role in human disease.
  65. Regulation of Digestive Vesicular Glutamate Transporter
    Liqun Bai; Fiscal Year: 2006
    ..The long-term goal of our laboratory is to study the regulation of vesicular glutamate transporter in digestive system. The primary purpose of this proposal is to determine the mechanisms of glucose-induced regulation of ..
  66. Regulation of Digestive Vesicular Glutamate Transporter
    Liqun Bai; Fiscal Year: 2004
    ..The long-term goal of our laboratory is to study the regulation of vesicular glutamate transporter in digestive system. The primary purpose of this proposal is to determine the mechanisms of glucose-induced regulation of ..
  67. Mechanisms of alimentary chemosensation
    STEVEN MUNGER; Fiscal Year: 2009
    ..In Aim 2, we will characterize the role of two hormones expressed in taste cells and in the digestive system, glucagon-like peptide-1 (GLP-1) and glucagon, in the modulation of taste sensitivity...
  68. Regulation of Digestive Vesicular Glutamate Transporter
    Liqun Bai; Fiscal Year: 2007
    ..The long-term goal of our laboratory is to study the regulation of vesicular glutamate transporter in digestive system. The primary purpose of this proposal is to determine the mechanisms of glucose-induced regulation of ..
  69. Regulation and Dynamics of Keratins in Digestive Organs
    M Omary; Fiscal Year: 2006
    ..Our proposed studies are likely to generate important new biologic information regarding keratins in the digestive system, and to help clarify their function and role in human disease.
  70. Regulation and Dynamics of Keratins in Digestive Organs
    M Omary; Fiscal Year: 2003
    ..Our proposed studies are likely to generate important new biologic information regarding keratins in the digestive system, and to help clarify their function and role in human disease.
  71. Regulation of Digestive Vesicular Glutamate Transporter
    Liqun Bai; Fiscal Year: 2005
    ..The long-term goal of our laboratory is to study the regulation of vesicular glutamate transporter in digestive system. The primary purpose of this proposal is to determine the mechanisms of glucose-induced regulation of ..
  72. Regulation and Dynamics of Keratins in Digestive Organs
    M Omary; Fiscal Year: 2002
    ..Our proposed studies are likely to generate important new biologic information regarding keratins in the digestive system, and to help clarify their function and role in human disease.
  73. SKN-1 Regulation and Oxidative Stress Resistance in C. elegans
    Thomas Blackwell; Fiscal Year: 2006
    ..In the embryo, maternally provided SKN-1 initiates development of the feeding/digestive system. We have found that during postembryonic stages SKN-1 is expressed in the intestine and ASI chemosensory ..
  74. SKN-1 Regulation and Oxidative Stress Resistance in C. elegans
    Thomas Blackwell; Fiscal Year: 2007
    ..In the embryo, maternally provided SKN-1 initiates development of the feeding/digestive system. We have found that during postembryonic stages SKN-1 is expressed in the intestine and ASI chemosensory ..
  75. Neural Circuitry in the Caudal Solitary Complex
    Bret Smith; Fiscal Year: 2005
    ..fibers of the vagus nerve from the digestive tract, neurons in the nucleus tractus solitarius (NTS) process digestive system information prior to further integration via higher brain areas and eventual activation of motor output to ..
  76. ION TRANSPORT MECHANISMS IN BLOOD CELLS
    PHILIP KNAUF; Fiscal Year: 2002
    ..B3 and B3RP's are also important in epithelia, particularly those of the kidney and digestive system that are involved in secretion of acid or base...
  77. Little Brain Big Brain Meeting
    David Linden; Fiscal Year: 2009
    ..This conference, called the Little Brain Big Brain, referring to the interaction between nerve cells in the digestive system and nerve cells in the brain and spinal cord, gathers scientists from around the world to study new ways to ..
  78. Neural Circuitry in the Caudal Solitary Complex
    Bret Smith; Fiscal Year: 2001
    ..fibers of the vagus nerve from the digestive tract, neurons in the nucleus tractus solitarius (NTS) process digestive system information prior to further integration via higher brain areas and eventual activation of motor output to ..