pluripotent stem cells

Summary

Summary: Cells that can give rise to most types of cells but not all types of cells necessary for fetal development. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)

Top Publications

  1. ncbi Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
    Cell 126:663-76. 2006
  2. ncbi Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 131:861-72. 2007
  3. ncbi Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
  4. ncbi Generation of germline-competent induced pluripotent stem cells
    Keisuke Okita
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nature 448:313-7. 2007
  5. ncbi In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    Marius Wernig
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 448:318-24. 2007
  6. ncbi Reprogramming of human somatic cells to pluripotency with defined factors
    In Hyun Park
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 451:141-6. 2008
  7. ncbi Disease-specific induced pluripotent stem cells
    In Hyun Park
    Department of Medicine, Division of Pediatric Hematology Oncology, Children s Hospital Boston, and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 134:877-86. 2008
  8. ncbi Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    Frank Soldner
    The Whitehead Institute, Cambridge Center, MA 02142, USA
    Cell 136:964-77. 2009
  9. ncbi Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    John T Dimos
    Harvard Stem Cell Institute, Stowers Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Science 321:1218-21. 2008
  10. ncbi Derivation of pluripotent epiblast stem cells from mammalian embryos
    I Gabrielle M Brons
    Department of Surgery and Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0XY, UK
    Nature 448:191-5. 2007

Research Grants

  1. Protein-induced human iPS cells for personalized cell therapy of PD
    Kwang Soo Kim; Fiscal Year: 2010
  2. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2011
  3. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
  4. Cellular dissection of herpes simplex encephalitis with iPS cells
    Jean Laurent Casanova; Fiscal Year: 2010
  5. Targeting SMN2 Alternative Splicing for the Treatment of Spinal Muscular Atrophy
    Michelle L Hastings; Fiscal Year: 2010
  6. DIFFERENTIATION OF ENDOCRINE CELL LINEAGES IN GI TRACT
    Andrew Leiter; Fiscal Year: 2001
  7. Role of OCT4 in reprogramming human skin keratinocytes
    Jackie R Bickenbach; Fiscal Year: 2011
  8. Role of OCT4 in reprogramming human skin keratinocytes
    Jackie R Bickenbach; Fiscal Year: 2010
  9. Multipotent stem cells for tissue regeneration
    Song Li; Fiscal Year: 2010
  10. PANCREATIC HORMONES
    DONALD STEINER; Fiscal Year: 1990

Detail Information

Publications331 found, 100 shown here

  1. ncbi Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
    Cell 126:663-76. 2006
    ..Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, ..
  2. ncbi Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 131:861-72. 2007
    ..Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts...
  3. ncbi Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
    ..show that four factors (OCT4, SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells...
  4. ncbi Generation of germline-competent induced pluripotent stem cells
    Keisuke Okita
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nature 448:313-7. 2007
    We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) expression...
  5. ncbi In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    Marius Wernig
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 448:318-24. 2007
    ..Our results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells.
  6. ncbi Reprogramming of human somatic cells to pluripotency with defined factors
    In Hyun Park
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 451:141-6. 2008
    ..These data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture...
  7. ncbi Disease-specific induced pluripotent stem cells
    In Hyun Park
    Department of Medicine, Division of Pediatric Hematology Oncology, Children s Hospital Boston, and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 134:877-86. 2008
    ..Such disease-specific stem cells offer an unprecedented opportunity to recapitulate both normal and pathologic human tissue formation in vitro, thereby enabling disease investigation and drug development...
  8. ncbi Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    Frank Soldner
    The Whitehead Institute, Cambridge Center, MA 02142, USA
    Cell 136:964-77. 2009
    Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for replacement therapies...
  9. ncbi Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    John T Dimos
    Harvard Stem Cell Institute, Stowers Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Science 321:1218-21. 2008
    The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease...
  10. ncbi Derivation of pluripotent epiblast stem cells from mammalian embryos
    I Gabrielle M Brons
    Department of Surgery and Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0XY, UK
    Nature 448:191-5. 2007
    ..Here we show that pluripotent stem cells can be derived from the late epiblast layer of post-implantation mouse and rat embryos using chemically ..
  11. ncbi Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    Tarjei S Mikkelsen
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Nature 448:553-60. 2007
    ..This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations...
  12. ncbi New cell lines from mouse epiblast share defining features with human embryonic stem cells
    Paul J Tesar
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 448:196-9. 2007
    ..These results show that epiblast cells can be maintained as stable cell lines and interrogated to understand how pluripotent cells generate distinct fates during early development...
  13. ncbi Human induced pluripotent stem cells free of vector and transgene sequences
    Junying Yu
    Morgridge Institute for Research, Madison, WI 53707 7365, USA
    Science 324:797-801. 2009
    ..These results demonstrate that reprogramming human somatic cells does not require genomic integration or the continued presence of exogenous reprogramming factors and removes one obstacle to the clinical application of human iPS cells...
  14. ncbi Induced pluripotent stem cells from a spinal muscular atrophy patient
    Allison D Ebert
    The Waisman Center, The Stem Cell and Regenerative Medicine Center, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Nature 457:277-80. 2009
    ..Here we report the generation of induced pluripotent stem cells from skin fibroblast samples taken from a child with spinal muscular atrophy...
  15. ncbi Virus-free induction of pluripotency and subsequent excision of reprogramming factors
    Keisuke Kaji
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Nature 458:771-5. 2009
    ....
  16. ncbi piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
    Knut Woltjen
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Nature 458:766-70. 2009
    ..We anticipate that the unique properties of this virus-independent simplification of iPS cell production will accelerate this field further towards full exploration of the reprogramming process and future cell-based therapies...
  17. ncbi The ground state of embryonic stem cell self-renewal
    Qi Long Ying
    Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
    Nature 453:519-23. 2008
    ..This property may account for their latent tumorigenicity. The delineation of minimal requirements for self-renewal now provides a defined platform for the precise description and dissection of the pluripotent state...
  18. ncbi Dissecting direct reprogramming through integrative genomic analysis
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 454:49-55. 2008
    ..We demonstrate that RNA inhibition of transcription factors can facilitate reprogramming, and that treatment with DNA methyltransferase inhibitors can improve the overall efficiency of the reprogramming process...
  19. ncbi Generation of mouse induced pluripotent stem cells without viral vectors
    Keisuke Okita
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:949-53. 2008
    ..The production of virus-free iPS cells, albeit from embryonic fibroblasts, addresses a critical safety concern for potential use of iPS cells in regenerative medicine...
  20. ncbi Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:111-23. 2009
    Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from embryonic stem cells (ESCs)...
  21. ncbi Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
    Masato Nakagawa
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nat Biotechnol 26:101-6. 2008
    Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouse fibroblasts by retroviral transduction of ..
  22. ncbi Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 107:9222-7. 2010
    ..The generation of validated "naïve" human ESCs will allow the molecular dissection of a previously undefined pluripotent state in humans and may open up new opportunities for patient-specific, disease-relevant research...
  23. ncbi Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
    Matthias Stadtfeld
    Howard Hughes Medical Institute at Massachusetts General Hospital, Center for Regenerative Medicine Harvard Stem Cell Institute, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 465:175-81. 2010
    Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of defined sets of transcription factors in somatic cells...
  24. ncbi Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    Bao Yang Hu
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin, Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 107:4335-40. 2010
    For the promise of human induced pluripotent stem cells (iPSCs) to be realized, it is necessary to ask if and how efficiently they may be differentiated to functional cells of various lineages...
  25. ncbi Adult mice generated from induced pluripotent stem cells
    Michael J Boland
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 461:91-4. 2009
    ....
  26. ncbi Induced pluripotent stem cells generated without viral integration
    Matthias Stadtfeld
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA
    Science 322:945-9. 2008
    b>Pluripotent stem cells have been generated from mouse and human somatic cells by viral expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc...
  27. ncbi Generation of induced pluripotent stem cells using recombinant proteins
    Hongyan Zhou
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Stem Cell 4:381-4. 2009
  28. ncbi Direct cell reprogramming is a stochastic process amenable to acceleration
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 462:595-601. 2009
    ....
  29. ncbi Functional cardiomyocytes derived from human induced pluripotent stem cells
    Jianhua Zhang
    Department of Medicine, University of Wisconsin, WiCell Research Institute, Madison, WI 53792 3248, USA
    Circ Res 104:e30-41. 2009
    ..We conclude that human iPS cells can differentiate into functional cardiomyocytes, and thus iPS cells are a viable option as an autologous cell source for cardiac repair and a powerful tool for cardiovascular research...
  30. ncbi Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors
    Jeong Beom Kim
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Munster, NRW, Germany
    Nature 454:646-50. 2008
    ..mechanisms of regaining pluripotency and further opens up the possibility of generating patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced ..
  31. ncbi Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
    Frank Soldner
    The Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 146:318-31. 2011
    Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies...
  32. ncbi Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    Louise C Laurent
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Stem Cell 8:106-18. 2011
    Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on 186 pluripotent and 119 nonpluripotent samples...
  33. ncbi Klf4 reverts developmentally programmed restriction of ground state pluripotency
    Ge Guo
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK
    Development 136:1063-9. 2009
    ..However, because a single transgene is the minimum requirement to attain the ground state, EpiSCs offer an attractive opportunity for screening for unknown components of the reprogramming process...
  34. ncbi Modelling schizophrenia using human induced pluripotent stem cells
    Kristen J Brennand
    Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla California 92037, USA
    Nature 473:221-5. 2011
    ..and molecular defects of SCZD, we directly reprogrammed fibroblasts from SCZD patients into human induced pluripotent stem cells (hiPSCs) and subsequently differentiated these disorder-specific hiPSCs into neurons (Supplementary Fig...
  35. ncbi Extrinsic regulation of pluripotent stem cells
    Martin F Pera
    Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Nature 465:713-20. 2010
    ..Understanding the extrinsic control of plasticity will guide efforts to use human pluripotent stem cells in research and therapy.
  36. ncbi Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10065, USA
    Nat Biotechnol 27:275-80. 2009
    ..Noggin/SB431542-based neural induction should facilitate the use of hES and hiPS cells in regenerative medicine and disease modeling and obviate the need for protocols based on stromal feeders or embryoid bodies...
  37. ncbi Direct reprogramming of human neural stem cells by OCT4
    Jeong Beom Kim
    Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Röntgenstrasse 20, 48149 Munster, NRW, Germany
    Nature 461:649-3. 2009
    ..One-factor iPS cell generation will advance the field further towards understanding reprogramming and generating patient-specific pluripotent stem cells.
  38. ncbi Generation of pluripotent stem cells from patients with type 1 diabetes
    Rene Maehr
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:15768-73. 2009
    ..These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy...
  39. ncbi Global transcription in pluripotent embryonic stem cells
    Sol Efroni
    National Cancer Institute Center for Bioinformatics, National Institutes of Health, Rockville, MD 20852, USA
    Cell Stem Cell 2:437-47. 2008
    ..We propose that global transcription is a hallmark of pluripotent ESCs, contributing to their plasticity, and that lineage specification is driven by reduction of the transcribed portion of the genome...
  40. ncbi Oct4-induced pluripotency in adult neural stem cells
    Jeong Beom Kim
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Munster, NRW, Germany
    Cell 136:411-9. 2009
    ..that exogenous expression of the germline-specific transcription factor Oct4 is sufficient to generate pluripotent stem cells from adult mouse NSCs...
  41. ncbi Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
    Gunnar Hargus
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 107:15921-6. 2010
    ....
  42. ncbi Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
    Jacob Hanna
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Science 318:1920-3. 2007
    ..The problems associated with using retroviruses and oncogenes for reprogramming need to be resolved before iPS cells can be considered for human therapy...
  43. ncbi A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
    Hitoshi Niwa
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 6500047, Japan
    Nature 460:118-22. 2009
    ....
  44. ncbi Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
    Angel Raya
    Center for Regenerative Medicine in Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain
    Nature 460:53-9. 2009
    ..These data offer proof-of-concept that iPS cell technology can be used for the generation of disease-corrected, patient-specific cells with potential value for cell therapy applications...
  45. ncbi Generation of pluripotent stem cells from adult mouse liver and stomach cells
    Takashi Aoi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 321:699-702. 2008
    ..These data suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required...
  46. ncbi Transcriptional signature and memory retention of human-induced pluripotent stem cells
    Maria C N Marchetto
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California, USA
    PLoS ONE 4:e7076. 2009
    Genetic reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells or iPSCs) by over-expression of specific genes has been accomplished using mouse and human cells...
  47. ncbi Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells
    Tobias Brambrink
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell Stem Cell 2:151-9. 2008
    ..Importantly, the virally transduced cDNAs needed to be expressed for at least 12 days in order to generate iPS cells. Our results are a step toward understanding some of the molecular events governing epigenetic reprogramming...
  48. ncbi Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
    Dirk Hockemeyer
    The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Biotechnol 27:851-7. 2009
    Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) requires efficient methods for genetic modification...
  49. ncbi Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 133:250-64. 2008
    ..Our study provides definite proof for the direct nuclear reprogramming of terminally differentiated adult cells to pluripotency...
  50. ncbi Induction of pluripotent stem cells from fibroblast cultures
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara machi, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nat Protoc 2:3081-9. 2007
    ..One way to circumvent these issues is to generate pluripotent stem cells directly from somatic cells...
  51. ncbi Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    Fabio Mohn
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Mol Cell 30:755-66. 2008
    ..These data suggest a model how de novo DNA methylation and dynamic switches in Polycomb targets restrict pluripotency and define the developmental potential of progenitor cells...
  52. ncbi Myc represses primitive endoderm differentiation in pluripotent stem cells
    Keriayn N Smith
    Department of Biochemistry and Molecular Biology, Paul D Coverdell Center for Biomedical and Health Sciences, The University of Georgia, 500 D W Brooks Drive, Athens, GA 30602, USA
    Cell Stem Cell 7:343-54. 2010
    The generation of induced pluripotent stem cells (iPSCs) provides a novel method to facilitate investigations into the mechanisms that control stem cell pluripotency and self-renewal...
  53. ncbi Naive and primed pluripotent states
    Jennifer Nichols
    Wellcome Trust Centre for Stem Cell Research, Department of Physiology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Cell Stem Cell 4:487-92. 2009
    ..We propose that two phases of pluripotency can be defined: naive and primed. This distinction extends to pluripotent stem cells derived from embryos or by molecular reprogramming ex vivo.
  54. ncbi Lab-specific gene expression signatures in pluripotent stem cells
    Aaron M Newman
    Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106, USA
    Cell Stem Cell 7:258-62. 2010
    b>Pluripotent stem cells derived from both embryonic and reprogrammed somatic cells have significant potential for human regenerative medicine...
  55. ncbi Variation in the safety of induced pluripotent stem cell lines
    Kyoko Miura
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
    Nat Biotechnol 27:743-5. 2009
    ..In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells...
  56. ncbi Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
    R David Hawkins
    Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA
    Cell Stem Cell 6:479-91. 2010
    ..Our results provide new insights into epigenetic mechanisms underlying properties of pluripotency and cell fate commitment...
  57. ncbi Polycomb complexes repress developmental regulators in murine embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 441:349-53. 2006
    ..Our results indicate that dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development...
  58. ncbi Regulatory networks define phenotypic classes of human stem cell lines
    Franz Josef Muller
    Center for Regenerative Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 455:401-5. 2008
    ..Our results offer a new strategy for classifying stem cells and support the idea that pluripotency and self-renewal are under tight control by specific molecular networks...
  59. ncbi Cardiomyocyte differentiation of human induced pluripotent stem cells
    Limor Zwi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 120:1513-23. 2009
    ..In the present study, we aimed to characterize the cardiomyocyte differentiation potential of hiPS cells and to study the molecular, structural, and functional properties of the generated hiPS-derived cardiomyocytes...
  60. ncbi Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells
    Timothy J Nelson
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 120:408-16. 2009
    Nuclear reprogramming provides an emerging strategy to produce embryo-independent pluripotent stem cells from somatic tissue...
  61. ncbi Pluripotency of spermatogonial stem cells from adult mouse testis
    Kaomei Guan
    Department of Cardiology and Pneumology, Heart Center, , Robert-Koch-Str. 40, , Germany
    Nature 440:1199-203. 2006
    ..Furthermore, these cells may provide new opportunities to study genetic diseases in various cell lineages...
  62. ncbi iPS cells produce viable mice through tetraploid complementation
    Xiao yang Zhao
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Nature 461:86-90. 2009
    ..We demonstrate the practicality of using iPS cells as useful tools for the characterization of cellular reprogramming and developmental potency, and confirm that iPS cells can attain true pluripotency that is similar to that of ES cells...
  63. ncbi Chd1 regulates open chromatin and pluripotency of embryonic stem cells
    Alexandre Gaspar-Maia
    Department of Ob Gyn and Pathology, Center for Reproductive Sciences and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0525, USA
    Nature 460:863-8. 2009
    ..Our results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state...
  64. ncbi Engineering of human pluripotent stem cells by AAV-mediated gene targeting
    Iram F Khan
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Mol Ther 18:1192-9. 2010
    Precise genetic manipulation of human pluripotent stem cells will be required to realize their scientific and therapeutic potential...
  65. ncbi Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    Ian Chambers
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland
    Cell 113:643-55. 2003
    ..These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity...
  66. ncbi A functionally characterized test set of human induced pluripotent stem cells
    Gabriella L Boulting
    The Howard Hughes Medical Institute, Cambridge, Massachusetts, USA
    Nat Biotechnol 29:279-86. 2011
    Human induced pluripotent stem cells (iPSCs) present exciting opportunities for studying development and for in vitro disease modeling. However, reported variability in the behavior of iPSCs has called their utility into question...
  67. ncbi Stepwise differentiation of pluripotent stem cells into retinal cells
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe, Japan
    Nat Protoc 4:811-24. 2009
    ..It will also improve our understanding of the development of the central nervous system, especially the eye...
  68. ncbi Metastable pluripotent states in NOD-mouse-derived ESCs
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Stem Cell 4:513-24. 2009
    ..Our findings suggest that stem cells from different genetic backgrounds can assume distinct states of pluripotency in vitro, the stability of which is regulated by endogenous genetic determinants and can be modified by exogenous factors...
  69. ncbi Promotion of reprogramming to ground state pluripotency by signal inhibition
    Jose Silva
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 6:e253. 2008
    ..We therefore applied molecularly defined conditions for the derivation and propagation of authentic pluripotent stem cells from embryos...
  70. ncbi Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells
    Tibor Kalmar
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000149. 2009
    ....
  71. ncbi A high-efficiency system for the generation and study of human induced pluripotent stem cells
    Nimet Maherali
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Massachusetts General Hospital Center for Regenerative Medicine, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Cell Stem Cell 3:340-5. 2008
    ..lentiviral system to convert primary human fibroblasts and keratinocytes into human induced pluripotent stem cells (hiPSCs)...
  72. ncbi Strategies and new developments in the generation of patient-specific pluripotent stem cells
    Shinya Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell Stem Cell 1:39-49. 2007
    Generating pluripotent stem cells directly from cells obtained from patients is one of the ultimate goals in regenerative medicine...
  73. ncbi Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
    Matthias Stadtfeld
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA
    Cell Stem Cell 2:230-40. 2008
    ..Our results suggest that factor-induced reprogramming is a gradual process with defined intermediate cell populations that contain the majority of cells poised to become iPS cells...
  74. ncbi Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    Marius Wernig
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:5856-61. 2008
    ..Our results demonstrate the therapeutic potential of directly reprogrammed fibroblasts for neuronal cell replacement in the animal model...
  75. ncbi Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
    Donghui Zhang
    Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China
    Cell Res 19:429-38. 2009
    Human pluripotent stem cells represent a potentially unlimited source of functional pancreatic endocrine lineage cells...
  76. ncbi Nuclear reprogramming and pluripotency
    Konrad Hochedlinger
    Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 441:1061-7. 2006
    ..The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes...
  77. ncbi Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, One Breakthrough Way, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 105:19756-61. 2008
    ..This suggests that Sall4 plays a diverse role in regulating stem cell pluripotency during early embryonic development through integration of transcriptional and epigenetic controls...
  78. ncbi Generation of induced pluripotent stem cells from human blood
    Yuin Han Loh
    Department of Medicine, Division of Pediatric Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 113:5476-9. 2009
    ..Here, we describe the derivation of induced pluripotent stem cells from CD34+ mobilized human peripheral blood cells using retroviral transduction of OCT4/SOX2/KLF4/MYC...
  79. ncbi Elite and stochastic models for induced pluripotent stem cell generation
    Shinya Yamanaka
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Nature 460:49-52. 2009
    Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete...
  80. ncbi Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells
    Alexander Kleger
    Institute for Anatomy and Cell Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Circulation 122:1823-36. 2010
    ..Here we have investigated their impact on the differentiation of pluripotent cells toward the cardiac lineage...
  81. ncbi The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla
    Fang Liu
    AntiCancer Inc, San Diego, CA, USA
    Cell Cycle 10:830-9. 2011
    ..The nestin-expressing pluripotent stem cells from the DP have been termed skin precursor or SKP cells...
  82. ncbi Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells
    Genta Narazaki
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Circulation 118:498-506. 2008
    ..However, detailed differentiation properties and the directional differentiation system of iPS cells have not been demonstrated...
  83. ncbi Gene targeting in human pluripotent stem cells with adeno-associated virus vectors
    Kaoru Mitsui
    Gene Therapy Division, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    Biochem Biophys Res Commun 388:711-7. 2009
    Human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), have the ability to differentiate into various cell types, and will become a potential source of cellular materials for ..
  84. ncbi Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells
    David E Buchholz
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California 93106, USA
    Stem Cells 27:2427-34. 2009
    Human induced pluripotent stem cells (iPSCs) have great promise for cellular therapy, but it is unclear if they have the same potential as human embryonic stem cells (hESCs) to differentiate into specialized cell types...
  85. ncbi Differentiation of human oligodendrocytes from pluripotent stem cells
    Bao Yang Hu
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Protoc 4:1614-22. 2009
    ..This 3-month differentiation protocol consistently yields OPCs of high purity capable of producing myelin sheaths in vivo...
  86. ncbi Hematopoietic development from human induced pluripotent stem cells
    Claudia Lengerke
    Division of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany
    Ann N Y Acad Sci 1176:219-27. 2009
    ..embryonic stem cells (ESC) has paved the way for the discovery of alternative approaches to generating pluripotent stem cells. Combinatorial overexpression of a limited number of proteins linked to pluripotency in ESC was recently ..
  87. ncbi Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
    Costas A Lyssiotis
    Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:8912-7. 2009
    ..Ultimately, such compounds may provide mechanistic insight into the reprogramming process...
  88. ncbi Histone arginine methylation regulates pluripotency in the early mouse embryo
    Maria Elena Torres-Padilla
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 445:214-8. 2007
    ..Thus, our results identify specific histone modifications as the earliest known epigenetic marker contributing to development of ICM and show that manipulation of epigenetic information influences cell fate determination...
  89. ncbi Germ cell specification in mice
    Katsuhiko Hayashi
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Science 316:394-6. 2007
    ..Blimp1 may also have a role in the maintenance of early germ cell characteristics by ensuring their escape from the somatic fate as well as possible reversion to pluripotent stem cells.
  90. ncbi Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 9:625-35. 2007
    ..These results indicate that the essential function of Sox2 is to stabilize ES cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression...
  91. ncbi ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
    Xiaolin Gao
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Richard Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:6656-61. 2008
    ..Our results suggest that BAF250a is a key component of the gene regulatory machinery in ES cells controlling self-renewal, differentiation, and cell lineage decisions...
  92. ncbi Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
    BMC Dev Biol 8:45. 2008
    Rex1/Zfp42 has been extensively used as a marker for the undifferentiated state of pluripotent stem cells. However, its function in pluripotent stem cells including embryonic stem (ES) cells remained unclear although its involvement in ..
  93. ncbi Induced pluripotent cells mimicking human embryonic stem cells
    Mehdi Mohamadnejad
    Digestive Disease Research Center, Medical Sciences/ University of Tehran, Tehran, Iran
    Arch Iran Med 11:125-8. 2008
  94. ncbi Derivation of embryonic stem cell line from frozen human embryos and neural differentiation
    Ji chun Tan
    Department of Medical Genetics, China Medical University, Shenyang, China
    Neuroreport 19:1451-5. 2008
    ..After the induction of cyclic AMP for 7 days, the neural progenitor cells had differentiated into neurons and glial cells...
  95. ncbi Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling
    Lesley Gerrard
    Department of Gene Function and Development, Roslin Institute, Roslin, Midlothian, EH25 9PS, UK
    Stem Cells 23:1234-41. 2005
    ..Our findings will provide a platform for studying the molecular mechanism controlling neural differentiation...
  96. ncbi Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Cell 10:105-16. 2006
    ....
  97. ncbi Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001
    Sandii N Brimble
    BresaGen, Inc, Athens, GA 30605, USA
    Stem Cells Dev 13:585-97. 2004
    ..self-renewal, maintenance of normal karyotype, and gene expression indicative of undifferentiated pluripotent stem cells. A survey of gene expression in BG02 cells using massively parallel signature sequencing generated a ..
  98. ncbi Isolation of murine and porcine fetal stem cells from somatic tissue
    Wilfried A Kues
    Department of Biotechnology, , Mariensee, D-31535 Neustadt, Germany
    Biol Reprod 72:1020-8. 2005
    ..We report that fetal tissue contains somatic stem cells with greater potency than previously thought, which might form a new source of stem cells useful in somatic nuclear transfer and cell therapy...
  99. ncbi Improved cryopreservation of human embryonic stem cells with trehalose
    Chun Fang Wu
    Shanghai Key Laboratory of Tissue Engineering, Shanghai 9th People's Hospital, Shanghai 2nd Medical University, Shanghai 200011, China
    Reprod Biomed Online 11:733-9. 2005
    ..Cells retained pluripotency with normal karyotype after thawing. The results indicated that the use of trehalose is efficient and convenient for cryopreservation of human ES cells...
  100. ncbi Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells
    Lei Xiao
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Stem Cells 24:1476-86. 2006
    ..Our data indicates Activin A as a key regulator in maintenance of the stemness in hESCs. This finding will help elucidate the complex signaling network that maintains the hESC phenotype and function...
  101. ncbi Identification of an enhancer that controls up-regulation of fibronectin during differentiation of embryonic stem cells into extraembryonic endoderm
    Tetsu Shirai
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical School, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Biol Chem 280:7244-52. 2005
    ..This enhancer carries Sox protein-binding sequences, and our analysis demonstrated that Sox7 and Sox17, which are highly expressed in the extraembryonic endoderm, were involved in enhancer activity...

Research Grants102 found, 100 shown here

  1. Protein-induced human iPS cells for personalized cell therapy of PD
    Kwang Soo Kim; Fiscal Year: 2010
    ..In 2006, Shinya Yamanaka and his colleagues published their groundbreaking work showing that pluripotent stem cells, so called "induced pluripotent stem cells (iPSCs)", can be generated from somatic cells by retroviral ..
  2. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2011
    ..Aim 4 will attempt to re-create EVT from infants born to mothers with PE by generating induced pluripotent stem cells (iPSC) from discarded umbilical cord and converting these pluripotent cells to CT, EVT and other lineages ..
  3. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..validated in vitro models of adult, mesenchymal, stem cell commitment and differentiation, namely, adult, pluripotent stem cells isolated from lipoaspirates, and muscle stem cells isolated from regenerating skeletal muscle of adult ..
  4. Cellular dissection of herpes simplex encephalitis with iPS cells
    Jean Laurent Casanova; Fiscal Year: 2010
    ..and NEMO) and from patients with other inborn errors of IFN immunity (mutation in TYK2) to derive induced pluripotent stem cells (iPSCs). These iPSCs will then be differentiated into neurons, oligodendrocytes, and astrocytes...
  5. Targeting SMN2 Alternative Splicing for the Treatment of Spinal Muscular Atrophy
    Michelle L Hastings; Fiscal Year: 2010
    ..Aim 1 of this study is to use induced pluripotent stem cells derived from SMA patients to determine the effectiveness of splicing effector molecules, such as the ..
  6. DIFFERENTIATION OF ENDOCRINE CELL LINEAGES IN GI TRACT
    Andrew Leiter; Fiscal Year: 2001
    ..The Principal Investigator has preliminary data indicating that pluripotent stem cells give rise to PYY progenitors that then differentiate into other endocrine cells...
  7. Role of OCT4 in reprogramming human skin keratinocytes
    Jackie R Bickenbach; Fiscal Year: 2011
    ..sufficient to reactivate endogenous embryonic factors required to reprogram human skin keratinocytes into pluripotent stem cells. To test our hypothesis, we propose the following Specific Aims: 1) Reprogram adult human skin ..
  8. Role of OCT4 in reprogramming human skin keratinocytes
    Jackie R Bickenbach; Fiscal Year: 2010
    ..sufficient to reactivate endogenous embryonic factors required to reprogram human skin keratinocytes into pluripotent stem cells. To test our hypothesis, we propose the following Specific Aims: 1) Reprogram adult human skin ..
  9. Multipotent stem cells for tissue regeneration
    Song Li; Fiscal Year: 2010
    Stem cells have tremendous potential in regenerative medicine applications. The generation of induced pluripotent stem cells (iPSCs) bypasses the ethical and immune rejection issues of human embryonic stem cells (hESCs), and provides an ..
  10. PANCREATIC HORMONES
    DONALD STEINER; Fiscal Year: 1990
    ..differentiation and growth of islet cells using clonally derived insulinoma lines having the properties of pluripotent stem cells. (8) Studies on the structure of the insulin receptor with special emphasis on the molecular mechanisms of ..
  11. Maturation of Normal and Disease-specific Human Stem Cell-derived Cardiomyocytes
    Huei Sheng Vincent Chen; Fiscal Year: 2010
    ..Recent progress in cellular reprogramming of various somatic cell types into induced pluripotent stem cells (iPSCs) opened the door for developing patient-specific, cell-based therapies...
  12. Rest-Activated Program of Gene Expression in Ischemia
    R Suzanne Zukin; Fiscal Year: 2010
    ..factor that is widely expressed during embryogenesis and plays a strategic role in the transition from pluripotent stem cells to neurons...
  13. Rest-Activated Program of Gene Expression in Ischemia
    R Suzanne Zukin; Fiscal Year: 2010
    ..factor that is widely expressed during embryogenesis and plays a strategic role in the transition from pluripotent stem cells to neurons...
  14. Cardiac Induction by Small Molecule BMP Inhibitors
    Charles C Hong; Fiscal Year: 2010
    ..have introduced the prospect of replacing damaged heart tissues with healthy cardiomyocytes derived from pluripotent stem cells. However, realizing the full therapeutic potential of stem cells faces numerous hurdles, including the ..
  15. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2005
    ..switch is fundamentally the same as those that occur during the production of distinct lineages from pluripotent stem cells in humans...
  16. Use of Clenbuterol for Enhancement of Stem Cell Therapy
    Richard Zeman; Fiscal Year: 2002
    ..The proposed studies are an outgrowth of previous work in which Beta2-agonists or transplantation of adult pluripotent stem cells into the contusion site enhanced recovery of locomotor function following SCI in rats...
  17. Molecular Dissection of the Hematopoeic Microenvironment
    Kateri Moore; Fiscal Year: 2005
    ..It has been shown that these pluripotent stem cells reside in discrete niches within a hematopoietic organ...
  18. GENE TARGETING STRATEGIES FOR THE TREATMENT OF OSTEOGENESIS IMPERFECTA
    David Russell; Fiscal Year: 2009
    ..this competitive revision application we propose to overcome this potential limitation by deriving induced pluripotent stem cells (iPSCs) from OI MSCs, which are immortal and capable of differentiating into MSCs and forming bone in vivo...
  19. Pluripotent Stem Cells in Development and Disease
    Gerald Schatten; Fiscal Year: 2007
    ..important questions in stem cell medicine and biology through responsible studies on the potentials of pluripotent stem cells from humans (hESC) and nonhuman primates (nhpESC) during development in vitro and in utero, and after ..