neutrophils

Summary

Summary: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Top Publications

  1. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
  2. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  3. ncbi Neutrophils in the activation and regulation of innate and adaptive immunity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Nat Rev Immunol 11:519-31. 2011
  4. ncbi Neutrophils, from marrow to microbes
    Niels Borregaard
    The Granulocyte Research Laboratory, Department of Hematology, National University Hospital Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Immunity 33:657-70. 2010
  5. ncbi Neutrophils in tuberculosis: friend or foe?
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Trends Immunol 33:14-25. 2012
  6. pmc Novel cell death program leads to neutrophil extracellular traps
    Tobias A Fuchs
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    J Cell Biol 176:231-41. 2007
  7. ncbi A transgenic zebrafish model of neutrophilic inflammation
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Blood 108:3976-8. 2006
  8. pmc Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    Zvi G Fridlender
    Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Cancer Cell 16:183-94. 2009
  9. ncbi Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
    Jean M Daley
    Department of Surgery, Division of Surgical Research, Rhode Island Hospital, NAB 214, 593 Eddy Street, Providence, RI 02903, USA
    J Leukoc Biol 83:64-70. 2008
  10. pmc Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    Saswata Talukdar
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 18:1407-12. 2012

Detail Information

Publications350 found, 100 shown here

  1. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
    b>Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome...
  2. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  3. ncbi Neutrophils in the activation and regulation of innate and adaptive immunity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Nat Rev Immunol 11:519-31. 2011
    b>Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells...
  4. ncbi Neutrophils, from marrow to microbes
    Niels Borregaard
    The Granulocyte Research Laboratory, Department of Hematology, National University Hospital Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Immunity 33:657-70. 2010
    b>Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules...
  5. ncbi Neutrophils in tuberculosis: friend or foe?
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Trends Immunol 33:14-25. 2012
    b>Neutrophils are rapidly recruited to sites of mycobacterial infection, where they phagocytose bacilli...
  6. pmc Novel cell death program leads to neutrophil extracellular traps
    Tobias A Fuchs
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    J Cell Biol 176:231-41. 2007
    ..We show that upon stimulation, the nuclei of neutrophils lose their shape, and the eu- and heterochromatin homogenize...
  7. ncbi A transgenic zebrafish model of neutrophilic inflammation
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Blood 108:3976-8. 2006
    ..fmk, demonstrating that experimental manipulation of the resolution of inflammation is possible in this model...
  8. pmc Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    Zvi G Fridlender
    Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Cancer Cell 16:183-94. 2009
    ..also increases neutrophil-attracting chemokines, resulting in an influx of CD11b(+)/Ly6G(+) tumor-associated neutrophils (TANs) that are hypersegmented, more cytotoxic to tumor cells, and express higher levels of proinflammatory ..
  9. ncbi Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
    Jean M Daley
    Department of Surgery, Division of Surgical Research, Rhode Island Hospital, NAB 214, 593 Eddy Street, Providence, RI 02903, USA
    J Leukoc Biol 83:64-70. 2008
    The anti-granulocyte receptor-1 (Gr-1) mAb, RB6-8C5, has been used extensively to deplete neutrophils in mice and to investigate the role of these cells in host defense...
  10. pmc Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
    Saswata Talukdar
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 18:1407-12. 2012
    ..b>Neutrophils are typically the first immune cells to respond to inflammation and can exacerbate the chronic inflammatory ..
  11. pmc PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
    Pingxin Li
    Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Exp Med 207:1853-62. 2010
    b>Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs)...
  12. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  13. pmc Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
    Teluguakula Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Am J Pathol 179:199-210. 2011
    ..Macrophages and neutrophils constitute the majority of cells recruited into infected lungs, and are associated with immunopathology in ..
  14. pmc Contribution of neutrophils to acute lung injury
    Jochen Grommes
    Department of Vascular Surgery, University Hospital, RWTH Aachen, Germany
    Mol Med 17:293-307. 2011
    ..Lung edema, endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and broncheoalveolar space...
  15. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
    ..lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some ..
  16. pmc Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 101:890-8. 1998
    ..Here we show that phagocytosis of apoptotic neutrophils (in contrast to immunoglobulin G-opsonized apoptotic cells) actively inhibited the production of interleukin (..
  17. ncbi Intravascular danger signals guide neutrophils to sites of sterile inflammation
    Braedon McDonald
    Immunology Research Group, University of Calgary, Alberta T2N 4N1, Canada
    Science 330:362-6. 2010
    b>Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage...
  18. pmc Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages
    Chao Tsung Yang
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 12:301-12. 2012
    b>Neutrophils are typically the first responders in host defense against invading pathogens, which they destroy by both oxidative and nonoxidative mechanisms...
  19. ncbi Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nat Med 13:1510-4. 2007
    ..staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection...
  20. ncbi Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines
    Viviane S Boaventura
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador, Brazil
    Eur J Immunol 40:2830-6. 2010
    ..b>Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and ..
  21. ncbi Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
    Stephen R Clark
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Med 13:463-9. 2007
    It has been known for many years that neutrophils and platelets participate in the pathogenesis of severe sepsis, but the inter-relationship between these players is completely unknown...
  22. pmc Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
    Abdul Hakkim
    Department of Cellular Microbiology and Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin 10117, Germany
    Proc Natl Acad Sci U S A 107:9813-8. 2010
    ..In SLE patients, infections can initiate flares and are a major cause of mortality. Neutrophils respond to infections and release extracellular traps (NETs), which are antimicrobial and are made of DNA, ..
  23. pmc Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
    Kathleen D Metzler
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Blood 117:953-9. 2011
    ..Here we show that neutrophils from donors who are completely deficient in MPO fail to form neutrophil extracellular traps (NETs), indicating ..
  24. ncbi Neutrophils and immunity: challenges and opportunities
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA
    Nat Rev Immunol 6:173-82. 2006
    Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease...
  25. ncbi Neutrophil function: from mechanisms to disease
    Borko Amulic
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Annu Rev Immunol 30:459-89. 2012
    b>Neutrophils are the most abundant white blood cells in circulation, and patients with congenital neutrophil deficiencies suffer from severe infections that are often fatal, underscoring the importance of these cells in immune defense...
  26. ncbi Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan
    Cell Host Microbe 12:109-16. 2012
    b>Neutrophils contribute to pathogen clearance by producing neutrophil extracellular traps (NETs), which are genomic DNA-based net-like structures that capture bacteria and fungi...
  27. pmc Restoration of NET formation by gene therapy in CGD controls aspergillosis
    Matteo Bianchi
    Division of Immunology Haematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    Blood 114:2619-22. 2009
    ..adenine dinucleotide phosphate (NADPH) oxidase function, resulting in poor antimicrobial activity of neutrophils, including the inability to generate neutrophil extracellular traps (NETs)...
  28. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...
  29. ncbi TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    A Bouchon
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Nature 410:1103-7. 2001
    Host innate responses to bacterial infections are primarily mediated by neutrophils and monocytes/macrophages...
  30. ncbi Multiple roles for neutrophils in atherosclerosis
    Oliver Soehnlein
    Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany
    Circ Res 110:875-88. 2012
    Because of their rare detection in atherosclerotic lesions, the involvement of neutrophils in the pathophysiology of atherosclerosis has been largely denied...
  31. ncbi Myeloperoxidase: friend and foe
    Seymour J Klebanoff
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 7185, USA
    J Leukoc Biol 77:598-625. 2005
    Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms...
  32. ncbi Tumor-associated neutrophils: new targets for cancer therapy
    Alyssa D Gregory
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 71:2411-6. 2011
    Studies have begun to emerge showing critical roles for neutrophils in tumorigenesis...
  33. pmc Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
    Eneida Villanueva
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 187:538-52. 2011
    ..a distinct neutrophil subset, their gene array profiles were compared with those of autologous normal-density neutrophils and control neutrophils...
  34. pmc Harmful molecular mechanisms in sepsis
    Daniel Rittirsch
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109 0602, USA
    Nat Rev Immunol 8:776-87. 2008
    ..In this Review, we highlight recent insights into the molecular interactions that occur during sepsis and attempt to unravel the nature of the dysregulated immune response during sepsis...
  35. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
    ..TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS...
  36. ncbi Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo
    Bryan G Yipp
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada 2The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:1386-93. 2012
    Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process requiring hours, leaving a temporal gap that invasive microbes may exploit...
  37. ncbi Toll-like receptors stimulate human neutrophil function
    Fumitaka Hayashi
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, USA
    Blood 102:2660-9. 2003
    The first immune cell to arrive at the site of infection is the neutrophil. Upon arrival, neutrophils quickly initiate microbicidal functions, including the production of antimicrobial products and proinflammatory cytokines that serve to ..
  38. pmc Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
    Venizelos Papayannopoulos
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Cell Biol 191:677-91. 2010
    b>Neutrophils release decondensed chromatin termed neutrophil extracellular traps (NETs) to trap and kill pathogens extracellularly...
  39. pmc Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
    Marie Luise von Brühl
    Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
    J Exp Med 209:819-35. 2012
    ..We demonstrate by intravital two-photon and epifluorescence microscopy that blood monocytes and neutrophils crawling along and adhering to the venous endothelium provide the initiating stimulus for DVT development...
  40. pmc Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps
    Anderson B Guimarães-Costa
    Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, Universidade Federal do Rio de Janeiro, Bloco I, 21941 902, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 106:6748-53. 2009
    b>Neutrophils are short-lived leukocytes that die by apoptosis, necrosis, and NETosis...
  41. ncbi An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
    Katharina Beiter
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna SE 171 82, Sweden
    Curr Biol 16:401-7. 2006
    ..It was recently shown that activated neutrophils release neutrophil extracellular traps (NETs), which contain antimicrobial proteins bound to a DNA scaffold...
  42. pmc A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1
    Janesh Pillay
    Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Invest 122:327-36. 2012
    ..Here, we report the identification of a subset of mature human neutrophils (CD11cbright/CD62Ldim/CD11bbright/CD16bright) as what we believe to be a unique circulating population of ..
  43. ncbi Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    De Broski R Herbert
    University of Cape Town, Health Sciences Faculty, 7925 Cape Town, South Africa
    Immunity 20:623-35. 2004
    ..Mortality was not dependent on neutrophils and occurred in the presence of T(H)2/Type 2 responses, granuloma formation, and egg-induced fibrosis...
  44. ncbi Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent
    Matteo Bianchi
    Division of Immunology Hematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    J Allergy Clin Immunol 127:1243-52.e7. 2011
    ..This process is defective in chronic granulomatous disease (CGD) because of impaired phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function...
  45. pmc Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans
    Constantin F Urban
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Pathog 5:e1000639. 2009
    b>Neutrophils are the first line of defense at the site of an infection...
  46. pmc Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
    Yanming Wang
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biol 184:205-13. 2009
    Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that have been implicated in innate immune response to bacterial infection...
  47. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..We further demonstrate that IL-17A produced by GR-1+ neutrophils was critical for kidney IRI in mice...
  48. ncbi Histone deimination as a response to inflammatory stimuli in neutrophils
    Indira Neeli
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 180:1895-902. 2008
    ..To examine conditions leading to histone deimination in neutrophils, we used Abs that detect citrullines in the N terminus of histone H3...
  49. ncbi Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma
    Hanne Krogh Jensen
    Department of Oncology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    J Clin Oncol 27:4709-17. 2009
    We have previously demonstrated a significant negative impact of intratumoral neutrophils in metastatic renal cell carcinoma. This study assessed intratumoral neutrophils in localized clear cell renal cell carcinoma (RCC).
  50. ncbi Evidence for a cross-talk between human neutrophils and Th17 cells
    Martin Pelletier
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    Blood 115:335-43. 2010
    ..several cytokines produced by T helper 17 cells (Th17), which are able to indirectly induce the recruitment of neutrophils. Recently, human Th17 cells have been phenotypically characterized and shown to express discrete chemokine ..
  51. ncbi Calprotectin (S100A8/S100A9), an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity
    Satoru Yui
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    Biol Pharm Bull 26:753-60. 2003
    ..two calcium-binding proteins that belong to the S100 protein family, is abundant in the cytosolic fraction of neutrophils. A high level of calprotectin reportedly exists in extracellular fluid during various inflammatory conditions, ..
  52. pmc B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
    Irene Puga
    Institut Municipal d Investigació Mèdica Hospital del Mar, Barcelona, Spain
    Nat Immunol 13:170-80. 2012
    b>Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin production is unknown...
  53. pmc Neutrophil extracellular trap cell death requires both autophagy and superoxide generation
    Quinten Remijsen
    IRC Laboratory of Biochemistry, Department of Medicine, KU Leuven Campus Kortrijk, Kortrijk, Belgium
    Cell Res 21:290-304. 2011
    ..They arise from neutrophils that have activated a cell death program called NET cell death, or NETosis...
  54. pmc Netting neutrophils in autoimmune small-vessel vasculitis
    Kai Kessenbrock
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Nat Med 15:623-5. 2009
    ..we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO)...
  55. ncbi Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    S R Walsh
    Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
    J Surg Oncol 91:181-4. 2005
    ..Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients...
  56. pmc Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    Flavia Bazzoni
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Proc Natl Acad Sci U S A 106:5282-7. 2009
    ..In this study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes...
  57. pmc The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
    Sebastien Jaillon
    Institut National de la Sante et de la Recherche Medicale, Equipe Avenir, Unité 564, University Hospital of Angers, University of Angers, Angers 49933, France
    J Exp Med 204:793-804. 2007
    ..Eosinophils and basophils do not contain preformed PTX3. PTX3-deficient neutrophils have defective microbial recognition and phagocytosis, and PTX3 is nonredundant for neutrophil-mediated ..
  58. ncbi Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans
    J B Cowland
    Granulocyte Research Laboratory, Finsen Center, Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genomics 45:17-23. 1997
    ..1, and the LPS-inducible factor NF-kappa B...
  59. pmc Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer
    W Chua
    Sydney Cancer Centre, Concord Repatriation General Hospital, Hospital Road, Concord, New South Wales 2139, Australia
    Br J Cancer 104:1288-95. 2011
    ..The use of inflammatory markers based on differential white-cell counts, such as the neutrophil/lymphocyte ratio (NLR), may be simple and readily available biomarkers...
  60. ncbi Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    L Kjeldsen
    Departments of Hematology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 268:10425-32. 1993
    ..protein was purified to apparent homogeneity from exocytosed material from phorbol myristate acetate-stimulated neutrophils. The primary structure of the 25-kDa protein was determined as a 178-residue protein...
  61. ncbi Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
    Constantin F Urban
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Cell Microbiol 8:668-76. 2006
    b>Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin...
  62. ncbi Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases
    Steffen Massberg
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Nat Med 16:887-96. 2010
    Blood neutrophils provide the first line of defense against pathogens but have also been implicated in thrombotic processes...
  63. ncbi Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill
    R Zahorec
    Department of Anaesthesiology and Intensive Care Medicine, St Elizabeth Cancer Institute, Bratislava
    Bratisl Lek Listy 102:5-14. 2001
    ..We investigate whether serial examination of white blood cell counts may reflect and clarify the immune response to stressful events in critically ill patients...
  64. ncbi Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
    Vered Elgazar-Carmon
    Infectious Diseases Laboratory, The S Daniel Abraham Center for Health and Nutrition, Faculty of Health Sciences, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel
    J Lipid Res 49:1894-903. 2008
    ..Here we demonstrate that early (3 and 7 days) after initiating high-fat feeding of C57BL/6J mice, neutrophils transiently infiltrate the parenchyma of intra-abdominal adipose tissue...
  65. ncbi Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer
    Mi Ran Jung
    Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
    J Surg Oncol 104:504-10. 2011
    ..Elevated neutrophil to lymphocyte ratio (N/L ratio) has been shown to be a prognostic indicator in various cancers. We aimed to investigate the prognostic significance of the preoperative N/L ratio in late stage gastric cancer...
  66. ncbi Metal chelation and inhibition of bacterial growth in tissue abscesses
    Brian D Corbin
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 319:962-5. 2008
    ..These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue...
  67. pmc Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    Br J Cancer 108:901-7. 2013
    ..Therefore, the aim of our study was the validation of the prognostic significance of NLR in a large cohort of RCC patients...
  68. ncbi Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide
    Heather Parker
    Department of Pathology, University of Otago Christchurch, 2 Riccarton Ave, Christchurch, New Zealand
    J Leukoc Biol 91:369-76. 2012
    ..b>Neutrophils were stimulated with PMA to release NETs...
  69. pmc The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
    Abigail Woodfin
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Nat Immunol 12:761-9. 2011
    The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity...
  70. pmc The role of neutrophils during mild and severe influenza virus infections of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 6:e17618. 2011
    b>Neutrophils have been implicated in both protective and pathological responses following influenza virus infections...
  71. ncbi In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
    Janesh Pillay
    Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Blood 116:625-7. 2010
    b>Neutrophils are essential effector cells of the innate immune response and are indispensable for host defense. Apart from their antimicrobial functions, neutrophils inform and shape subsequent immunity...
  72. ncbi Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    E Hirsch
    Department of Genetics, Biology and Biochemistry, University of Torino, Turin, Italy
    Science 287:1049-53. 2000
    ..guanine nucleotide-binding protein (G protein)-coupled PI3Kgamma were viable and had fully differentiated neutrophils and macrophages...
  73. pmc Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection
    Bisweswar Nandi
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:2251-62. 2011
    ..Regulation of neutrophils is important because their accumulation is detrimental to the host...
  74. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ..mice was accompanied by (i) increased (>200-fold) viral replication, (ii) greater influx of neutrophils into the lung, (iii) increased numbers of alveolar macrophages (AMs), and (iv) increased protein expression of ..
  75. ncbi The neutrophil in vascular inflammation
    Mia Phillipson
    Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden
    Nat Med 17:1381-90. 2011
    Here we focus on how neutrophils have a key regulatory role in vascular inflammation...
  76. ncbi How human neutrophils kill and degrade microbes: an integrated view
    William M Nauseef
    Inflammation Program, Department of Medicine, University of Iowa, Iowa City, IA 52241, USA
    Immunol Rev 219:88-102. 2007
    b>Neutrophils constitute the dominant cell in the circulation that mediates the earliest innate immune human responses to infection...
  77. ncbi S100A8 and S100A9 in inflammation and cancer
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem Pharmacol 72:1622-31. 2006
    ..proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation...
  78. ncbi Beneficial suicide: why neutrophils die to make NETs
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Chariteplatz 1, Berlin 10117, Germany
    Nat Rev Microbiol 5:577-82. 2007
    b>Neutrophils are one of the main types of effector cell in the innate immune system and were first shown to effectively kill microorganisms by phagocytosis more than 100 years ago...
  79. ncbi Neutrophils: Cinderella of innate immune system
    V Kumar
    Department of Pediatrics, Faculty of Medicine, Sainte Justine Hospital, University of Montreal, Montreal, Canada
    Int Immunopharmacol 10:1325-34. 2010
    b>Neutrophils are the first line of innate immune defense against infectious diseases...
  80. ncbi Molecular circuits of resolution: formation and actions of resolvins and protectins
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:4345-55. 2005
    ..These results characterize the first molecular resolution circuits and their major components activated by specific novel lipid mediators (i.e., resolvin E1 and 10,17S-docosatriene) to promote resolution...
  81. ncbi Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils
    Xiaoming Zhang
    Institut Pasteur, Unité Régulation Immunitaire et Vaccinologie, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Immunity 31:761-71. 2009
    b>Neutrophils are one of the first lines of defense against microbial pathogens and are rapidly recruited at the infection site upon inflammatory conditions...
  82. ncbi Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
    Jovanka M Voyich
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 194:1761-70. 2006
    ..Moreover, lysis of human neutrophils and pathogen survival after phagocytosis were similar between wild-type and mutant strains...
  83. ncbi Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Biol Chem 279:21085-95. 2004
    ..Apoptotic neutrophils possessed reduced levels of serine-phosphorylated Bax correlating with an increase in activated Bax as well as ..
  84. ncbi Breaching the basement membrane: who, when and how?
    R Grant Rowe
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, 210 Washtenaw, Ann Arbor, MI 48109 2216, USA
    Trends Cell Biol 18:560-74. 2008
    ..Further characterization of the molecular mechanisms underlying BM transmigration should provide important insights into pathophysiologic tissue remodeling events and also enable the development of novel therapeutics...
  85. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..In neutrophils, however, IL-1beta secretion is caspase-1 independent and depends on serine proteases, whose activity is also ..
  86. pmc Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 107:5587-92. 2010
    ..These findings provide insights into the mechanism of PVL-induced lung injury and inflammation and demonstrate the utility of the rabbit for studying PVL-mediated pathogenesis...
  87. ncbi Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
    ....
  88. pmc Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing
    Lucy V Norling
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:5543-7. 2011
    ..These findings indicate that humanized NPs, termed nano-proresolving medicines, are mimetics of endogenous resolving mechanisms, possess potent beneficial bioactions, can reduce nanotoxicity, and offer new therapeutic approaches...
  89. pmc Extracellular histones are major mediators of death in sepsis
    Jun Xu
    Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Nat Med 15:1318-21. 2009
    ..We conclude that extracellular histones are potential molecular targets for therapeutics for sepsis and other inflammatory diseases...
  90. pmc TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils
    Adebusola Alagbala Ajibade
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 36:43-54. 2012
    ..Compared with wild-type cells, TAK1-deficient neutrophils enhanced the phosphorylation of the kinases IKK, p38, and JNK and the production of interleukin-1β (IL-1β), ..
  91. ncbi ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors
    Yu Chen
    Department of Surgery, University of California San Diego, San Diego, CA 92103, USA
    Science 314:1792-5. 2006
    Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and ..
  92. ncbi Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology
    Claudia A Dumitru
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstrase 55, Essen, Germany
    Cancer Immunol Immunother 61:1155-67. 2012
    ..In this review, we will address in detail the following major topics: (1) neutrophils and GrMDSCs in the peripheral blood of cancer patients-phenotype and functional changes; (2) neutrophils and ..
  93. pmc Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality
    Q Remijsen
    Department of Biomedical Molecular Biology, Molecular Signaling and Cell Death Unit, Ghent University, Ghent, Belgium
    Cell Death Differ 18:581-8. 2011
    ..Ex vivo, both dead and viable neutrophils can be stimulated to release NETs composed of either nuclear or mitochondrial chromatin, respectively...
  94. pmc LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    - De Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick, MD, USA
    J Exp Med 192:1069-74. 2000
    ..LL-37/hCAP18 is produced by neutrophils and various epithelial cells...
  95. pmc Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    Andrew M Lin
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 187:490-500. 2011
    ..However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin...
  96. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized...
  97. ncbi CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
    Veronica Marcos
    Research Center, Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Nat Med 16:1018-23. 2010
    Upon activation, neutrophils release DNA fibers decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs)...
  98. ncbi Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
    Mauro Perretti
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Nat Rev Immunol 9:62-70. 2009
    ..In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation...
  99. ncbi Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    J D Pollock
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    Nat Genet 9:202-9. 1995
    ..This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in inflammation...
  100. ncbi Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages
    Aisleen McColl
    Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 183:2167-75. 2009
    ..containing C4-binding protein and protein S responsible for the augmentation of phagocytosis of apoptotic neutrophils. Because the apoptotic neutrophils used in this study specifically bind protein S, we suggest that ..
  101. ncbi NETs: a new strategy for using old weapons
    Venizelos Papayannopoulos
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Trends Immunol 30:513-21. 2009
    As key players in the host innate immune response, neutrophils are recruited to sites of infection and constitute the first line of defense...

Research Grants75

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..OPN-L), in synovial fluid samples from rheumatoid arthritis patients and these cleaved OPN forms affect neutrophils and fibroblast-like synoviocytes...
  2. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..epithelial cells-Glp1r, Pik3r1 and Lcn2-as well as genes encoding proteins- Gzmb and Prf1-that are expressed by neutrophils, macrophages and cytotoxic T-lymphocytes that infiltrate the lung during systemic inflammatory states such as T/..
  3. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Although neutrophils are the dominant white blood cell in alveoli and bronchioles during acute infection (day 2-14), and engulf ..
  4. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..The specific aims are: 1) Characterize PerR-dependent and independent GAS responses to ROS generated by human neutrophils;2) Determine whether the perR-linked DNA polymerase I (polA...
  5. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..of NADPH oxidase (Nox2), a multimeric enzyme complex first described as the respiratory burst oxidase in neutrophils. Nox2 is designed to produce large amounts of reactive oxygen species (ROS), primarily superoxide anion...
  6. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..Polymorphonuclear neutrophils (PMN) represent the cornerstone of cell-mediated antimicrobial activity and exert ~ all of their antimicrobial ..
  7. TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATION
    Mary K Sheats; Fiscal Year: 2013
    ..White blood cells involved in the inflammatory response, such as neutrophils, are essential both to host defense from invading microorganisms and wound healing and repair...
  8. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..Considerable observational and experimental data support a tight correlation between neutrophils and the severity and progression of the above airways diseases...
  9. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..In addition to macrophages and neutrophils, lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T ..
  10. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..aureus strains in an in vitro assay with human neutrophils. In addition, passive transfer of CP5-EPA antibodies resulted in a 98% reduction in S...
  11. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..Deletion of SHP-1 specifically in neutrophils (using MRP8-Cre) recapitulates much of the inflammatory disease in present in mev/mev mice but the animals don&..
  12. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..mice exhibited exaggerated levels of NF-(B and proinflammatory cytokines associated with increased influx of neutrophils, whereas these responses were attenuated in lungs of SIRT1 transgenic mice exposed to CS...
  13. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..Neutrophil infiltration is a hallmark of alcoholic hepatitis, and infiltrating neutrophils are thought to play an etiologic role in the liver injury in ALD...
  14. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..Vaccine-induced T17 cells mediated protection by recruiting and activating neutrophils and alveolar macrophages to the alveolar space to augment fungal killing...
  15. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..These Th17 CD4+ T cells generate proteins that recruit neutrophils and are generated via activation of the transcription factors ROR t and ROR ...
  16. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..Chemotactic factors produced as a result of substance P release recruit neutrophils, monocytes, macrophages, and lymphocytes to the local site...
  17. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..We and others have shown that in addition to macrophages and neutrophils, lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T ..
  18. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary / Abstract Neutrophils comprise the first line of host defense, killing invading microbes by generating reactive oxygen species (ROS) through an activatable NADPH oxidase system...
  19. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..The infectious process systemically activates immune cells of the host, including neutrophils and macrophages, which trigger a pro-inflammatory response that contributes to eradication of the invading ..
  20. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..plaques and histology that shows a markedly hyperproliferative epithelium (acanthosis) with infiltration of neutrophils and CD4+ (helper) and CD8+ (cytotoxic/suppressor) lymphocytes, as well as growth and dilation of blood vessels ..
  21. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..Resident macrophages (Kupffer cells) and recruited neutrophils are the main cell types directly responsible for parenchymal cell damage...
  22. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..Since the human mucosa is colonized by 500-1000 bacterial species, differences in FPR function could affect the neutrophils'ability to respond to certain bacterial peptides and therefore impair the innate immune response, ..
  23. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..factor (G- CSF) is a 19 kDa protein that stimulates bone marrow cells to divide and differentiate into neutrophils. Recombinant human G-CSF is widely used to treat chemotherapy-related neutropenia in cancer patients, and ..
  24. NOX1 and NOX2 as Therapeutic Targets in Influenza
    JOHN DAVID LAMBETH; Fiscal Year: 2013
    ..alveolar fluid transport, apoptosis of alveolar epithelial cells, an infiltration/destruction of lung tissue by neutrophils and monocytes. Currently, effective treatments to prevent lung damage do not exist...
  25. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..In I/R, when the supply of blood is restored to the affected area, neutrophils cause damage to healthy tissue via the massive release of reactive oxygen species (ROS)...
  26. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..HIF-11 mediates many critical functions of macrophages and neutrophils in inflammation4;6...
  27. Prevention of Retinal Degeneration by Crystallins in Experimental Uveitis
    Narsing A Rao; Fiscal Year: 2011
    ..i. During the late phase, macrophages/neutrophils infiltrate the retina, and photoreceptor damage is noted histologically...
  28. PREVENTION OF QUINONE TOXICITY AND MUTAGENICITY
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..DKO mice showed hyperoxic lung injury/infiltration with neutrophils. This together with epidemiological reports of association between NQO1P187S mutation and asthma raise ..
  29. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..disease (CD) and ulcerative colitis (UC) are chronic diseases characterized by a pronounced infiltration of neutrophils (PMNs) into colonic mucosal lesions, accompanied by epithelial cell necrosis and ulceration...
  30. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..factor (GM-CSF) is a 14 kDa cytokine that stimulates bone marrow cells to divide and differentiate into neutrophils and macrophages...
  31. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neutrophils and macrophages are often overwhelmed by systemic anthrax infection...
  32. Inhibitors of S. aureus bNOS for adjunctive therapy
    Donald T Moir; Fiscal Year: 2013
    ..bNOS inhibitors will provide an adjunctive therapeutic approach to bolster the effectiveness of antibiotics and neutrophils against MRSA and potentially reduce the selective pressure for development of drug-resistance by increasing the ..
  33. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..NSPs) (elastase, cathepsin G and proteinase-3) released at inflammatory sites by degranulating or necrotic neutrophils are major contributors to the pathology of cystic fibrosis and chronic obstructive pulmonary disease (COPD)...
  34. Mechanisms of adaptive immunity to P. aeruginosa in the lung
    Gregory P Priebe; Fiscal Year: 2013
    ..bronchoalveolar lavage fluid compared with control vaccines, and is associated with more rapid recruitment of neutrophils to the airways...
  35. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    ..The particular cell types of interest will be mast cells, basophils, eosinophils, neutrophils, macrophages, monocytes, dendritic cells, T cells, and B cells...
  36. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..We have also found metabolic pathways critical for NTHi survival in the lung and depletion of neutrophils alleviates NTHi's requirement for these pathways...
  37. Dysregulation of the inflammatory response by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2013
    ..Accumulation of neutrophils (polymorphonuclear leukocytes, PMNs) in the lungs is essential for development of severe disease in animals ..
  38. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..mice and normally infiltrate the Act1-deficient CNS but fail to recruit hematogenously derived lymphocytes, neutrophils, and macrophages into the CNS...
  39. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..been shown that many of the systemic changes noted with the model are associated with the release of activated neutrophils (PMNs) from the lung into the systemic circulation and that this activation could be reversed by the ..
  40. Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidase
    Moti L Kashyap; Fiscal Year: 2013
    ..In regards to understanding the mechanisms for formation of dysfunctional HDL, evidence points to a role for neutrophils myeloperoxidase (MPO)-generated oxidants as participants in rendering HDL dysfunctional...
  41. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..A possible reason for this improvement is reduction of VILI. Neutrophils have been shown to play a crucial role in the pathogenesis of VILI and we recently demonstrated that neutrophil ..
  42. Bordetella Cyclase Toxin:Effect on Leukocytes and Respiratory Epithelial Cells
    Erik L Hewlett; Fiscal Year: 2013
    ..It acts locally in the respiratory tract and is key in resisting bacterial clearance by neutrophils (PMN), yet its effects on the respiratory epithelium have not been studied...
  43. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    ..Trap production) is a programmed death pathway induced by pathogens and inflammatory mediators in which dying neutrophils extrude linearized DNA coated with potent antimicrobial enzymes: histones, myeloperoxidase and neutrophil ..
  44. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
    ..TLR4) to initiate a signaling cascade leading to cytokine expression by various cell types such as monocytes, neutrophils, and mucosal epithelial cells...
  45. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ..lower pulmonary artery pressures and cardiac strain, lower peripheral cytokines, and decreased sputum neutrophils despite being older and having a similar smoking history to those not using statins...
  46. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Phagocytic functions of neutrophils and macrophages are essential for immunity to microbial infection, but can also contribute to tissue injury during inflammatory responses and autoimmune ..
  47. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..Despite these clinical observations, a mechanism linking neutrophils to cardiovascular morbidity has not been identified...
  48. Selenoprotein K modulates calcium-dependent signaling in immune cells
    PETER R HOFFMAN; Fiscal Year: 2013
    ..novel transgenic mice with Sel K deleted in T cells (Lck-Cre) or myeloid cells including macrophages and neutrophils (Lyzs-Cre)...
  49. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..1) aneurysms will be produced in mice by activating inflammation (injecting activated macrophages and neutrophils into normal mouse carotid artery);and 2) performing an elastase saccular aneurysm model in immune-deficient ..
  50. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..by tobacco smoke that disrupts the epithelial barrier and induces a migration of different cell type such as neutrophils, macropages, T lymphocytes and natural killer cells through the airway epithelium...
  51. THE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATION
    TIMOTHY CRAGIN WANG; Fiscal Year: 2013
    ..that exhibit cell surface markers similar to myeloid-derived suppressor cells (MDSCs) or tumor-associated neutrophils (TAN). These HDC-expressing cells are recruited early on in an AOM/DSS model of colorectal carcinogenesis...
  52. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..lifespan of the CL;and (Aim 3) LH/steroid (P and/or E)-regulated migration and action of luteal macrophages and neutrophils is essential for CL regression...
  53. Host defense against Staphylococcus aureus skin infections
    Lloyd S Miller; Fiscal Year: 2010
    ..aureus infections in the skin, where most of these infections originate. The recruitment of neutrophils to the site of infection is the first line of defense against S...
  54. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..proposes a novel treatment by linking nano-fullerene to cFLFLF in order to specifically target activated neutrophils that migrate into the disc herniation site and treat acut back pain via peripheral vein injection, which is not ..
  55. ClC-3 ion transport modulates NADPH oxidase-dependent PMN priming by endotoxin
    Jessica G Moreland; Fiscal Year: 2012
    ..of neutrophil priming by bacterial products that are proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function and in the pathogenesis of Gram-negative sepsis.
  56. 5500 Q-Trap Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2010
    ..These include the proteasome complex in activated neutrophils, the enzymes in glycolysis and energy generating mitochondrial pathways, and the lens crystallins in aging...
  57. The role of neutrophil extracellular traps and NADPH oxidase in SLE pathogenesis
    ALLISON MARIE CAMPBELL; Fiscal Year: 2012
    ..that humans with an X-linked defect in NADPH oxidase and hence chronic granulomatous disease (CGD), whose neutrophils cannot form NETs have an increased predisposition to SLE...
  58. Mechanism of Neutrophil Activation
    Kenneth R McLeish; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neutrophils are a critical component of both the innate and adaptive immune responses that control microbial invasion...
  59. The Kidney, Hypertension, Pregnancy and Inflammation
    Babbette LaMarca; Fiscal Year: 2013
    ..Preeclamptic women have elevated circulating cytokines, neutrophils and lymphocytes producing an agonistic autoantibody to the angiotensin II type I receptor (AT1-AA)...
  60. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..We have also found metabolic pathways critical for NTHi survival in the lung and depletion of neutrophils alleviates NTHi[unreadable]s requirement for these pathways...
  61. TREM-1 in Lung Immune Response
    Ruxana T Sadikot; Fiscal Year: 2013
    ..on myeloid cells 1 (TREM-1) is a member of the super immunoglobulin family expressed on macrophage and neutrophils. Blockade of TREM-1 improves survival in lethal animal models of sepsis...
  62. Genetic and Epigenetic Regulation of Hematopoiesis.
    Shireen Saleque; Fiscal Year: 2013
    ..is required for maintaining functional integrity of adult stem cells in the bone marrow, the generation of neutrophils and appropriate lymphoid development...
  63. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..studies, as well as molecular epidemiological studies in humans, have provided evidence that the influx of neutrophils into the airways may be an important process linking inflammation with carcinogenesis...
  64. SEQUENTIAL MODEL OF LEUKOCYTE ROLLING AND ARREST IN FLOW
    Michael Lawrence; Fiscal Year: 1999
    ..described family of leukocyte adhesion receptors, the selectins, appear to mediate the distinctive rolling of neutrophils on the blood vessel wall that marks the early stages of acute inflammation...
  65. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..Project 12 focuses on the initial events in CNS inflammation including the role of innate cytokines and neutrophils in shaping both the innate and adaptive CNS immune response, and an exciting new approach to understanding how ..
  66. Regulation and function of nuclear envelope proteins in myelopoiesis and leukemia
    PETER CHARLES WIGRAM GAINES; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neutrophils and monocytes/macrophages are essential components of the innate immune system and function to eradicate bacterial and certain fungal infections...
  67. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..form of chronic inflammatory lung disease in preterm infants, is associated with the persistence of activated neutrophils in the lungs...
  68. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2002
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including ..
  69. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 2000
    ..The condition is marked by recruitment of inflammatory cells, in particular neutrophils, to the liver parenchyma. Once neutrophils invade the liver they can actively attack and destroy hepatocytes...
  70. PHASE 2 & 3 TRIALS OF HIGH-DOSE ORAL N-ACETYLCYSTEINE IN CYSTIC FIBROSIS
    Carol Conrad; Fiscal Year: 2007
    ..Recently, the applicant observed that redox imbalance in CF also occurs intracellularly, in blood neutrophils, featuring low levels of reduced glutathione (GSH)...
  71. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    Polymorphonuclear leukocytes, neutrophils, are the most abundant leukocytes in peripheral blood. They play a major role in innate immunity and may contribute to the development of the adaptive immune response...
  72. LIPID METABOLISM IN STIMULATED HUMAN PLATELETS
    M Broekman; Fiscal Year: 1991
    ..proposal is aimed at an understanding of the mechanisms by which resting and stimulated human platelets and neutrophils regulate levels of free arachidonate...
  73. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 2001
    Neutrophil sequestration and emigration in the lungs take place primarily in the capillaries. Rolling of neutrophils does not occur at this site, because most capillary segments are narrower than neutrophils...
  74. MECHANISMS OF NEUTROPHIL DYSFUNCTION IN BURNS AND TRAUMA
    Joseph Solomkin; Fiscal Year: 1993
    ..There is convincing evidence that this syndrome is due to degranulation and oxidant production by neutrophils in the alveolar interstitium...
  75. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    ALBERT T HSU; Fiscal Year: 2010
    ..involved in the pathogenesis of ARDS and MOSF likely results from reactive oxygen species (ROS) produced by neutrophils. There currently exists a 2-hit model for the development of MOSF following sepsis and trauma...