neutrophils

Summary

Summary: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Top Publications

  1. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
  2. doi Neutrophils in the activation and regulation of innate and adaptive immunity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Nat Rev Immunol 11:519-31. 2011
  3. pmc Novel cell death program leads to neutrophil extracellular traps
    Tobias A Fuchs
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    J Cell Biol 176:231-41. 2007
  4. pmc Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 101:890-8. 1998
  5. ncbi Neutrophils, from marrow to microbes
    Niels Borregaard
    The Granulocyte Research Laboratory, Department of Hematology, National University Hospital Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Immunity 33:657-70. 2010
  6. pmc Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
    Venizelos Papayannopoulos
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Cell Biol 191:677-91. 2010
  7. ncbi Neutrophils and immunity: challenges and opportunities
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA
    Nat Rev Immunol 6:173-82. 2006
  8. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
  9. pmc PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
    Pingxin Li
    Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Exp Med 207:1853-62. 2010
  10. pmc Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    Zvi G Fridlender
    Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Cancer Cell 16:183-94. 2009

Research Grants

  1. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
  2. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2010
  3. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
  4. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
  5. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
  6. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    WILLIAM NAUSEEF; Fiscal Year: 2009
  7. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
  8. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2004
  9. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2003
  10. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2002

Detail Information

Publications319 found, 100 shown here

  1. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
    b>Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome...
  2. doi Neutrophils in the activation and regulation of innate and adaptive immunity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Nat Rev Immunol 11:519-31. 2011
    b>Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells...
  3. pmc Novel cell death program leads to neutrophil extracellular traps
    Tobias A Fuchs
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    J Cell Biol 176:231-41. 2007
    ..We show that upon stimulation, the nuclei of neutrophils lose their shape, and the eu- and heterochromatin homogenize...
  4. pmc Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 101:890-8. 1998
    ..Here we show that phagocytosis of apoptotic neutrophils (in contrast to immunoglobulin G-opsonized apoptotic cells) actively inhibited the production of interleukin (..
  5. ncbi Neutrophils, from marrow to microbes
    Niels Borregaard
    The Granulocyte Research Laboratory, Department of Hematology, National University Hospital Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Immunity 33:657-70. 2010
    b>Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules...
  6. pmc Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
    Venizelos Papayannopoulos
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Cell Biol 191:677-91. 2010
    b>Neutrophils release decondensed chromatin termed neutrophil extracellular traps (NETs) to trap and kill pathogens extracellularly...
  7. ncbi Neutrophils and immunity: challenges and opportunities
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA
    Nat Rev Immunol 6:173-82. 2006
    Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease...
  8. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
    ..lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils. Cytokine signals, epigenetic modifications and other microenvironmental factors can substantially and, in some ..
  9. pmc PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
    Pingxin Li
    Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Exp Med 207:1853-62. 2010
    b>Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs)...
  10. pmc Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    Zvi G Fridlender
    Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Cancer Cell 16:183-94. 2009
    ..also increases neutrophil-attracting chemokines, resulting in an influx of CD11b(+)/Ly6G(+) tumor-associated neutrophils (TANs) that are hypersegmented, more cytotoxic to tumor cells, and express higher levels of proinflammatory ..
  11. pmc Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
    Teluguakula Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore
    Am J Pathol 179:199-210. 2011
    ..Macrophages and neutrophils constitute the majority of cells recruited into infected lungs, and are associated with immunopathology in ..
  12. doi Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines
    Viviane S Boaventura
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador, Brazil
    Eur J Immunol 40:2830-6. 2010
    ..b>Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and ..
  13. ncbi Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
    Stephen R Clark
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Med 13:463-9. 2007
    It has been known for many years that neutrophils and platelets participate in the pathogenesis of severe sepsis, but the inter-relationship between these players is completely unknown...
  14. pmc Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
    Abdul Hakkim
    Department of Cellular Microbiology and Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin 10117, Germany
    Proc Natl Acad Sci U S A 107:9813-8. 2010
    ..In SLE patients, infections can initiate flares and are a major cause of mortality. Neutrophils respond to infections and release extracellular traps (NETs), which are antimicrobial and are made of DNA, ..
  15. pmc Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans
    Constantin F Urban
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS Pathog 5:e1000639. 2009
    b>Neutrophils are the first line of defense at the site of an infection...
  16. pmc Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity
    Kathleen D Metzler
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Blood 117:953-9. 2011
    ..Here we show that neutrophils from donors who are completely deficient in MPO fail to form neutrophil extracellular traps (NETs), indicating ..
  17. ncbi Myeloperoxidase: friend and foe
    Seymour J Klebanoff
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 7185, USA
    J Leukoc Biol 77:598-625. 2005
    Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms...
  18. pmc Restoration of NET formation by gene therapy in CGD controls aspergillosis
    Matteo Bianchi
    Division of Immunology Haematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    Blood 114:2619-22. 2009
    ..adenine dinucleotide phosphate (NADPH) oxidase function, resulting in poor antimicrobial activity of neutrophils, including the inability to generate neutrophil extracellular traps (NETs)...
  19. ncbi Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nat Med 13:1510-4. 2007
    ..staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection...
  20. pmc Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
    Eneida Villanueva
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 187:538-52. 2011
    ..a distinct neutrophil subset, their gene array profiles were compared with those of autologous normal-density neutrophils and control neutrophils...
  21. pmc Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
    Yanming Wang
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biol 184:205-13. 2009
    Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that have been implicated in innate immune response to bacterial infection...
  22. doi Tumor-associated neutrophils: new targets for cancer therapy
    Alyssa D Gregory
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 71:2411-6. 2011
    Studies have begun to emerge showing critical roles for neutrophils in tumorigenesis...
  23. pmc Harmful molecular mechanisms in sepsis
    Daniel Rittirsch
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109 0602, USA
    Nat Rev Immunol 8:776-87. 2008
    ..In this Review, we highlight recent insights into the molecular interactions that occur during sepsis and attempt to unravel the nature of the dysregulated immune response during sepsis...
  24. doi Intravascular danger signals guide neutrophils to sites of sterile inflammation
    Braedon McDonald
    Immunology Research Group, University of Calgary, Alberta T2N 4N1, Canada
    Science 330:362-6. 2010
    b>Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage...
  25. ncbi Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
    Jean M Daley
    Department of Surgery, Division of Surgical Research, Rhode Island Hospital, NAB 214, 593 Eddy Street, Providence, RI 02903, USA
    J Leukoc Biol 83:64-70. 2008
    The anti-granulocyte receptor-1 (Gr-1) mAb, RB6-8C5, has been used extensively to deplete neutrophils in mice and to investigate the role of these cells in host defense...
  26. ncbi Toll-like receptors stimulate human neutrophil function
    Fumitaka Hayashi
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, USA
    Blood 102:2660-9. 2003
    The first immune cell to arrive at the site of infection is the neutrophil. Upon arrival, neutrophils quickly initiate microbicidal functions, including the production of antimicrobial products and proinflammatory cytokines that serve to ..
  27. pmc Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
    Marie Luise von Brühl
    Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
    J Exp Med 209:819-35. 2012
    ..We demonstrate by intravital two-photon and epifluorescence microscopy that blood monocytes and neutrophils crawling along and adhering to the venous endothelium provide the initiating stimulus for DVT development...
  28. pmc Contribution of neutrophils to acute lung injury
    Jochen Grommes
    Department of Vascular Surgery, University Hospital, RWTH Aachen, Germany
    Mol Med 17:293-307. 2011
    ..Lung edema, endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and broncheoalveolar space...
  29. pmc Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps
    Anderson B Guimarães-Costa
    Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, Universidade Federal do Rio de Janeiro, Bloco I, 21941 902, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 106:6748-53. 2009
    b>Neutrophils are short-lived leukocytes that die by apoptosis, necrosis, and NETosis...
  30. ncbi An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
    Katharina Beiter
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna SE 171 82, Sweden
    Curr Biol 16:401-7. 2006
    ..It was recently shown that activated neutrophils release neutrophil extracellular traps (NETs), which contain antimicrobial proteins bound to a DNA scaffold...
  31. pmc Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection
    Bisweswar Nandi
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:2251-62. 2011
    ..Regulation of neutrophils is important because their accumulation is detrimental to the host...
  32. doi Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent
    Matteo Bianchi
    Division of Immunology Hematology BMT, University Children s Hospital Zurich, Zurich, Switzerland
    J Allergy Clin Immunol 127:1243-52.e7. 2011
    ..This process is defective in chronic granulomatous disease (CGD) because of impaired phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function...
  33. ncbi Histone deimination as a response to inflammatory stimuli in neutrophils
    Indira Neeli
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 180:1895-902. 2008
    ..To examine conditions leading to histone deimination in neutrophils, we used Abs that detect citrullines in the N terminus of histone H3...
  34. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  35. pmc Netting neutrophils in autoimmune small-vessel vasculitis
    Kai Kessenbrock
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Nat Med 15:623-5. 2009
    ..we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO)...
  36. pmc Neutrophil extracellular trap cell death requires both autophagy and superoxide generation
    Quinten Remijsen
    IRC Laboratory of Biochemistry, Department of Medicine, KU Leuven Campus Kortrijk, Kortrijk, Belgium
    Cell Res 21:290-304. 2011
    ..They arise from neutrophils that have activated a cell death program called NET cell death, or NETosis...
  37. pmc The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
    Sebastien Jaillon
    Institut National de la Sante et de la Recherche Medicale, Equipe Avenir, Unité 564, University Hospital of Angers, University of Angers, Angers 49933, France
    J Exp Med 204:793-804. 2007
    ..Eosinophils and basophils do not contain preformed PTX3. PTX3-deficient neutrophils have defective microbial recognition and phagocytosis, and PTX3 is nonredundant for neutrophil-mediated ..
  38. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  39. doi Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases
    Steffen Massberg
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Nat Med 16:887-96. 2010
    Blood neutrophils provide the first line of defense against pathogens but have also been implicated in thrombotic processes...
  40. ncbi Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
    Constantin F Urban
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Cell Microbiol 8:668-76. 2006
    b>Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin...
  41. doi Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide
    Heather Parker
    Department of Pathology, University of Otago Christchurch, 2 Riccarton Ave, Christchurch, New Zealand
    J Leukoc Biol 91:369-76. 2012
    ..b>Neutrophils were stimulated with PMA to release NETs...
  42. ncbi Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    L Kjeldsen
    Departments of Hematology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 268:10425-32. 1993
    ..protein was purified to apparent homogeneity from exocytosed material from phorbol myristate acetate-stimulated neutrophils. The primary structure of the 25-kDa protein was determined as a 178-residue protein...
  43. pmc Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    Andrew M Lin
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 187:490-500. 2011
    ..However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin...
  44. pmc The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
    Abigail Woodfin
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Nat Immunol 12:761-9. 2011
    The migration of neutrophils into inflamed tissues is a fundamental component of innate immunity...
  45. pmc Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    Flavia Bazzoni
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Proc Natl Acad Sci U S A 106:5282-7. 2009
    ..In this study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes...
  46. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..We further demonstrate that IL-17A produced by GR-1+ neutrophils was critical for kidney IRI in mice...
  47. doi Neutrophils in tuberculosis: friend or foe?
    David M Lowe
    Department of Medicine, Imperial College London, W2 1PG, UK
    Trends Immunol 33:14-25. 2012
    b>Neutrophils are rapidly recruited to sites of mycobacterial infection, where they phagocytose bacilli...
  48. pmc The role of neutrophils during mild and severe influenza virus infections of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 6:e17618. 2011
    b>Neutrophils have been implicated in both protective and pathological responses following influenza virus infections...
  49. ncbi A transgenic zebrafish model of neutrophilic inflammation
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, Acadamic Unit of Respiratory Medicine, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Blood 108:3976-8. 2006
    ..fmk, demonstrating that experimental manipulation of the resolution of inflammation is possible in this model...
  50. ncbi In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days
    Janesh Pillay
    Department of Respiratory Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Blood 116:625-7. 2010
    b>Neutrophils are essential effector cells of the innate immune response and are indispensable for host defense. Apart from their antimicrobial functions, neutrophils inform and shape subsequent immunity...
  51. doi The neutrophil in vascular inflammation
    Mia Phillipson
    Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden
    Nat Med 17:1381-90. 2011
    Here we focus on how neutrophils have a key regulatory role in vascular inflammation...
  52. ncbi S100A8 and S100A9 in inflammation and cancer
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem Pharmacol 72:1622-31. 2006
    ..proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation...
  53. ncbi How human neutrophils kill and degrade microbes: an integrated view
    William M Nauseef
    Inflammation Program, Department of Medicine, University of Iowa, Iowa City, IA 52241, USA
    Immunol Rev 219:88-102. 2007
    b>Neutrophils constitute the dominant cell in the circulation that mediates the earliest innate immune human responses to infection...
  54. ncbi Beneficial suicide: why neutrophils die to make NETs
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Chariteplatz 1, Berlin 10117, Germany
    Nat Rev Microbiol 5:577-82. 2007
    b>Neutrophils are one of the main types of effector cell in the innate immune system and were first shown to effectively kill microorganisms by phagocytosis more than 100 years ago...
  55. ncbi Molecular circuits of resolution: formation and actions of resolvins and protectins
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:4345-55. 2005
    ..These results characterize the first molecular resolution circuits and their major components activated by specific novel lipid mediators (i.e., resolvin E1 and 10,17S-docosatriene) to promote resolution...
  56. doi Neutrophils: Cinderella of innate immune system
    V Kumar
    Department of Pediatrics, Faculty of Medicine, Sainte Justine Hospital, University of Montreal, Montreal, Canada
    Int Immunopharmacol 10:1325-34. 2010
    b>Neutrophils are the first line of innate immune defense against infectious diseases...
  57. ncbi Breaching the basement membrane: who, when and how?
    R Grant Rowe
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, 210 Washtenaw, Ann Arbor, MI 48109 2216, USA
    Trends Cell Biol 18:560-74. 2008
    ..Further characterization of the molecular mechanisms underlying BM transmigration should provide important insights into pathophysiologic tissue remodeling events and also enable the development of novel therapeutics...
  58. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..In neutrophils, however, IL-1beta secretion is caspase-1 independent and depends on serine proteases, whose activity is also ..
  59. pmc Extracellular histones are major mediators of death in sepsis
    Jun Xu
    Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Nat Med 15:1318-21. 2009
    ..We conclude that extracellular histones are potential molecular targets for therapeutics for sepsis and other inflammatory diseases...
  60. pmc Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 107:5587-92. 2010
    ..These findings provide insights into the mechanism of PVL-induced lung injury and inflammation and demonstrate the utility of the rabbit for studying PVL-mediated pathogenesis...
  61. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized...
  62. ncbi CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
    Veronica Marcos
    Research Center, Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Nat Med 16:1018-23. 2010
    Upon activation, neutrophils release DNA fibers decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs)...
  63. doi Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
    Mauro Perretti
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    Nat Rev Immunol 9:62-70. 2009
    ..In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation...
  64. ncbi Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
    J D Pollock
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    Nat Genet 9:202-9. 1995
    ..This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in inflammation...
  65. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ..mice was accompanied by (i) increased (>200-fold) viral replication, (ii) greater influx of neutrophils into the lung, (iii) increased numbers of alveolar macrophages (AMs), and (iv) increased protein expression of ..
  66. doi Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages
    Aisleen McColl
    Medical Research Council Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 183:2167-75. 2009
    ..containing C4-binding protein and protein S responsible for the augmentation of phagocytosis of apoptotic neutrophils. Because the apoptotic neutrophils used in this study specifically bind protein S, we suggest that ..
  67. ncbi NETs: a new strategy for using old weapons
    Venizelos Papayannopoulos
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Trends Immunol 30:513-21. 2009
    As key players in the host innate immune response, neutrophils are recruited to sites of infection and constitute the first line of defense...
  68. pmc Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA
    Sandra Bruns
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute HKI, Jena, Germany
    PLoS Pathog 6:e1000873. 2010
    ..Macrophages and neutrophils are known to kill conidia, whereas hyphae are killed mainly by neutrophils...
  69. ncbi Severity of E. coli mastitis is mainly determined by cow factors
    Christian Burvenich
    Mammary gland and Mastitis Research Centre, Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Res 34:521-64. 2003
    ..coli. Effective elimination of the pathogen by neutrophils is important for the resolution of infection and the outcome of E. coli mastitis...
  70. doi Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Immunol 183:7441-50. 2009
    ..We have defined a novel role for neutrophils in ameliorating lung injury during influenza infection, thereby limiting development of severe disease...
  71. pmc Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    Jiyun V Kim
    Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 457:191-5. 2009
    ..Here we report visualization of motile CTLs and massive secondary recruitment of pathogenic monocytes and neutrophils that were required for vascular leakage and acute lethality...
  72. ncbi Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    De Broski R Herbert
    University of Cape Town, Health Sciences Faculty, 7925 Cape Town, South Africa
    Immunity 20:623-35. 2004
    ..Mortality was not dependent on neutrophils and occurred in the presence of T(H)2/Type 2 responses, granuloma formation, and egg-induced fibrosis...
  73. doi A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus
    Florian H Pilsczek
    Snyder Institute of Infection, Immunity and Inflammation, Hiroshima University, Hiroshima, Japan
    J Immunol 185:7413-25. 2010
    ..reported that NETs take up to 3-4 h to form via an oxidant-dependent event that requires lytic death of neutrophils. In this study, we describe neutrophils responding uniquely to Staphylococcus aureus via a novel process of NET ..
  74. pmc CFTR-mediated halide transport in phagosomes of human neutrophils
    Richard G Painter
    Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Leukoc Biol 87:933-42. 2010
    ..against infection, providing the substrate for MPO-catalyzed production of HOCl in the phagosome of human neutrophils. Here, we used halide-specific fluorescent sensors covalently coupled to zymosan particles to investigate the ..
  75. pmc Yersinia pestis two-component gene regulatory systems promote survival in human neutrophils
    Jason L O'Loughlin
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 78:773-82. 2010
    Human polymorphonuclear leukocytes (PMNs, or neutrophils) are the most abundant innate immune cell and kill most invading bacteria through combined activities of reactive oxygen species (ROS) and antimicrobial granule constituents...
  76. pmc Recent developments and complexities in neutrophil transmigration
    Abigail Woodfin
    Queen Mary University of London, William Harvey Research Institute, UK
    Curr Opin Hematol 17:9-17. 2010
    As the migration of neutrophils from blood to inflamed tissues is an essential component of innate immunity and a key contributing factor to the pathogenesis of inflammatory disorders, this aspect of leukocyte biology continues to be a ..
  77. pmc Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice
    Henk van Faassen
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada
    Infect Immun 75:5597-608. 2007
    ..In this study, we examined the role of neutrophils in host resistance to pulmonary A. baumannii infection in a mouse model of intranasal (i.n.) infection...
  78. doi Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
    Xavier Houard
    INSERM U698, Paris 7 Denis Diderot University, Cardiovascular Hematology, Bio Engineering and Remodeling, Bichat Claude Bernard Hospital, 75877 Paris Cedex 18, France
    FASEB J 23:1376-83. 2009
    ..and LTA(4) hydrolase, as well as the two receptors for leukotriene B(4) (BLT1R and BLT2R), corresponding to neutrophils in the luminal part of the thrombus...
  79. ncbi The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
    Milan Chromek
    Department of Clinical Microbiology, Microbiology and Tumorbiology Center, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Nat Med 12:636-41. 2006
    ..In addition, clinical E. coli strains that were more resistant to LL-37 caused more severe urinary tract infections than did susceptible strains. Thus, cathelicidin seems to be a key factor in mucosal immunity of the urinary tract...
  80. doi The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis
    Andrew E Leitch
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Eur J Immunol 40:1127-38. 2010
    Successful resolution of inflammation requires inflammatory cells such as neutrophils to undergo apoptosis prior to non-inflammatory phagocytosis by professional phagocytes. Recently, cyclin-dependent kinase (CDK) inhibitors (e.g...
  81. pmc Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model
    Jadwiga Jablonska
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Clin Invest 120:1151-64. 2010
    ..tumor angiogenesis through repression of genes encoding proangiogenic and homing factors in tumor-infiltrating neutrophils. We determined that IFN-beta-deficient mice injected with B16F10 melanoma or MCA205 fibrosarcoma cells ..
  82. pmc Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis
    Richard C Chou
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 33:266-78. 2010
    ..We now demonstrate that BLT1 is required for neutrophils to deliver IL-1 into the joint to initiate arthritis...
  83. pmc Rapid neutrophil destruction following phagocytosis of Staphylococcus aureus
    Scott D Kobayashi
    Laboratory of Human Bacterial Pathogenesis, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Innate Immun 2:560-75. 2010
    ..incompletely defined, but presumably include evasion of killing by human polymorphonuclear leukocytes (PMNs or neutrophils)...
  84. doi A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes
    Jan Smagur
    Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    J Innate Immun 1:98-108. 2009
    Circulating neutrophils and monocytes form the first line of cellular defense against invading bacteria. Here, we describe a novel and specific mechanism of disabling and eliminating phagocytes by Staphylococcus aureus...
  85. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010
    b>Neutrophils are a major component of the innate immune response. Their homeostasis is maintained, in part, by the regulated release of neutrophils from the bone marrow...
  86. ncbi Neutrophil apoptosis: a target for enhancing the resolution of inflammation
    Janos G Filep
    Research Center, Maisonneuve Rosemont Hospital, Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec, Canada
    J Cell Biochem 108:1039-46. 2009
    b>Neutrophils are essential for host defense and their programmed cell death and removal are critical for the optimal expression as well as for efficient resolution of inflammation...
  87. pmc A paradoxical role for neutrophils in the pathogenesis of West Nile virus
    Fengwei Bai
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    J Infect Dis 202:1804-12. 2010
    ..Collectively, these data suggest that PMNs have a biphasic response to WNV infection, serving as a reservoir for replication and dissemination in early infection and later contributing to viral clearance...
  88. pmc Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    Paulo C Rodriguez
    Department of Microbiology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 69:1553-60. 2009
    ..These results may provide new insights on the mechanisms of tumor-induced anergy/tolerance and may help explain why some immunotherapies fail to induce an antitumor response...
  89. pmc Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2
    Richard E Person
    Department of Pathology, University of Washington School of Medicine, Box 357720, Seattle, Washington 98195, USA
    Nat Genet 34:308-12. 2003
    ....
  90. pmc Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury
    Rachel L Zemans
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 40:519-35. 2009
    The primary function of neutrophils in host defense is to contain and eradicate invading microbial pathogens...
  91. ncbi Neutrophils are associated with capillary closure in spontaneously diabetic monkey retinas
    Sahng Y Kim
    Wilmer Ophthalmological Institute, Johns Hopkins Hospital, 170 Woods Research Bldg, 600 North Wolfe St, Baltimore, MD 21287 9115, USA
    Diabetes 54:1534-42. 2005
    ..Retinas were incubated for ADPase (labels viable retinal blood vessels) and nonspecific esterase (labels neutrophils) activities. Polymorphonuclear leukocytes were counted per millimeter squared of retina...
  92. doi Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker
    Vineet Bhandari
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, LCI 401B, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 121:129-34. 2008
    ..The goal was to determine the utility of neutrophil CD64 as a diagnostic marker for sepsis in neonates...
  93. pmc CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis
    Richard G Painter
    Gene Therapy Program, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Biochemistry 45:10260-9. 2006
    Production of hypochlorous acid (HOCl) in neutrophils, a critical oxidant involved in bacterial killing, requires chloride anions...
  94. doi Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells
    Jan H N Lindeman
    Department of Vascular Surgery, K6R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 119:2209-16. 2009
    ..We thus hypothesized that doxycycline acts through an effect on vascular inflammation...
  95. ncbi Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
    Antonia M Joussen
    Retina Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 17:76-8. 2003
    ..Following the onset of streptozotocin-induced diabetes, FasL expression was increased in rat neutrophils (P<0.005) and was accompanied by a simultaneous increase in Fas expression in the retinal vasculature...
  96. ncbi Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
    Ming C Tsai
    Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 8:218-32. 2006
    ..The kinetics of recruitment of neutrophils, macrophages, dendritic cells, and T and B lymphocytes into the lungs of mice infected aerogenically with the ..
  97. ncbi Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair
    Jing Zhu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 111:867-78. 2002
    ..Supplying PEPI corrects the wound-healing defect in SLPI null mice. Thus, SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing...
  98. ncbi Evidence for a cross-talk between human neutrophils and Th17 cells
    Martin Pelletier
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    Blood 115:335-43. 2010
    ..several cytokines produced by T helper 17 cells (Th17), which are able to indirectly induce the recruitment of neutrophils. Recently, human Th17 cells have been phenotypically characterized and shown to express discrete chemokine ..
  99. doi Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Immunol Rev 225:244-55. 2008
    ..tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen...
  100. ncbi Role of neutrophils in a mouse model of halothane-induced liver injury
    Qiang You
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hepatology 44:1421-31. 2006
    ..Moreover, a higher number of neutrophils were recruited into the liver of Balb/c mice upon halothane treatment compared with DBA/1, with no obvious ..
  101. ncbi Compromised host defense on Pseudomonas aeruginosa biofilms: characterization of neutrophil and biofilm interactions
    Algirdas J Jesaitis
    Department of Microbiology, Montana State University, Bozeman, MT 59717 3520, USA
    J Immunol 171:4329-39. 2003
    ..We characterized the interaction of purified human neutrophils with P...

Research Grants86

  1. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
  2. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2010
    ..In recent studies, we found that HMGB1 inhibits phagocytosis of apoptotic neutrophils by macrophages in vivo and in vitro...
  3. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
  4. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..epithelial cells-Glp1r, Pik3r1 and Lcn2-as well as genes encoding proteins- Gzmb and Prf1-that are expressed by neutrophils, macrophages and cytotoxic T-lymphocytes that infiltrate the lung during systemic inflammatory states such as T/..
  5. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..studies, as well as molecular epidemiological studies in humans, have provided evidence that the influx of neutrophils into the airways may be an important process linking inflammation with carcinogenesis...
  6. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    WILLIAM NAUSEEF; Fiscal Year: 2009
    ..Polymorphonuclear neutrophils (PMN) represent the cornerstone of cell-mediated antimicrobial activity and exert ~ all of their antimicrobial ..
  7. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2005
    b>Neutrophils can cause impaired liver function, parenchymal injury and even liver failure during a number of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis,..
  8. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2004
    b>Neutrophils can cause impaired liver function, parenchymal injury and even liver failure during a number of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis,..
  9. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2003
    b>Neutrophils can cause impaired liver function, parenchymal injury and even liver failure during a number of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis,..
  10. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2002
    b>Neutrophils can cause impaired liver function, parenchymal injury and even liver failure during a number of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis,..
  11. NEUTROPHIL-INDUCED LIVER INJURY TOXICITY
    Hartmut Jaeschke; Fiscal Year: 2001
    b>Neutrophils can cause impaired liver function, parenchymal injury and even liver failure during a number of important clinical situations including hepatic ischemia-reperfusion, hemorrhagic shock and resuscitation, endotoxemia and sepsis,..
  12. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2010
    ..b>Neutrophils infiltrating the vasculature could cause inflammation and vasoconstriction by release of toxic compounds, such ..
  13. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
  14. SEQUENTIAL MODEL OF LEUKOCYTE ROLLING AND ARREST IN FLOW
    Michael Lawrence; Fiscal Year: 1999
    ..described family of leukocyte adhesion receptors, the selectins, appear to mediate the distinctive rolling of neutrophils on the blood vessel wall that marks the early stages of acute inflammation...
  15. Urokinase, Neutrophil Activation and Acute Lung Injury.
    Edward Abraham; Fiscal Year: 2010
    ..fibrinolytic pathways: 1) by enhancing neutrophil activation and 2) by decreasing phagocytosis and clearance of neutrophils in the lungs...
  16. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2003
    ..Project 12 focuses on the initial events in CNS inflammation including the role of innate cytokines and neutrophils in shaping both the innate and adaptive CNS immune response, and an exciting new approach to understanding how ..
  17. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..Project 12 focuses on the initial events in CNS inflammation including the role of innate cytokines and neutrophils in shaping both the innate and adaptive CNS immune response, and an exciting new approach to understanding how ..
  18. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2006
    ..Project 12 focuses on the initial events in CNS inflammation including the role of innate cytokines and neutrophils in shaping both the innate and adaptive CNS immune response, and an exciting new approach to understanding how ..
  19. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2005
    ..Project 12 focuses on the initial events in CNS inflammation including the role of innate cytokines and neutrophils in shaping both the innate and adaptive CNS immune response, and an exciting new approach to understanding how ..
  20. Microthrombus Formation Triggers Lung Injury in Sepsis
    Bruce Harms; Fiscal Year: 2009
    ..It is widely believed that cytotoxic agents released by neutrophils, the white blood cells that invade the lung during sepsis, cause the initial alveolar injury...
  21. VISCOELASTICITY OF WHITE BLOOD CELLS
    ROBERT HOCHMUTH; Fiscal Year: 1999
    ..characterize cytokine-stimulated adhesion receptor kinetics that enable endothelial cells to capture and guide neutrophils to the site of inflammation...
  22. VISCOELASTICITY OF WHITE BLOOD CELLS
    ROBERT HOCHMUTH; Fiscal Year: 2001
    ..characterize cytokine-stimulated adhesion receptor kinetics that enable endothelial cells to capture and guide neutrophils to the site of inflammation...
  23. VISCOELASTICITY OF WHITE BLOOD CELLS
    ROBERT HOCHMUTH; Fiscal Year: 2000
    ..characterize cytokine-stimulated adhesion receptor kinetics that enable endothelial cells to capture and guide neutrophils to the site of inflammation...
  24. RAS SIGNALING AND NEUTROPHIL ACTIVATION IN SLE
    Mark Philips; Fiscal Year: 1993
    Activated neutrophils are responsible for much of the tissue injury in systemic lupus erythematosus (SLE)...
  25. CELL SURFACE ANTIGENS OF HUMAN MACROPHAGES
    Robert Todd; Fiscal Year: 1993
    ..the surface antigens identified thus far, Mol, a two-subunit glycoprotein (gp 155, 94) expressed by monocytes, neutrophils, and bone marrow myeloid precursors, has a clear functional significance...
  26. CELL SURFACE ANTIGENS ON HUMAN MACROPHAGES
    Robert Todd; Fiscal Year: 1990
    ..the surface antigens identified thus far, Mol, a two-subunit glycoprotein (gp 155, 94) expressed by monocytes, neutrophils, and bone marrow myeloid precursors, has a clear functional significance...
  27. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2009
    ..In recent studies, we found that HMGB1 inhibits phagocytosis of apoptotic neutrophils by macrophages in vivo and in vitro...
  28. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya Mayadas; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Phagocytic functions of neutrophils and macrophages are essential for immunity to microbial infection, but can also contribute to tissue injury during inflammatory responses and autoimmune ..
  29. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..Considerable observational and experimental data support a tight correlation between neutrophils and the severity and progression of the above airways diseases...
  30. Anaplasma regulation of host granulocyte function
    John Stephen Dumler; Fiscal Year: 2010
    ..is an emerging tick-borne disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium of neutrophils. A...
  31. LIPID PATHWAYS AND LUNG INJURY
    David Bass; Fiscal Year: 2000
    ..Normal samples to be obtained will include blood cells (neutrophils, eosinophils, monocytes) and lung cells (isolated by bronchoalveolar lavage (BAL) or endobronchial biopsy or ..
  32. Regulation and function of nuclear envelope proteins in myelopoiesis and leukemia
    PETER CHARLES WIGRAM GAINES; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neutrophils and monocytes/macrophages are essential components of the innate immune system and function to eradicate bacterial and certain fungal infections...
  33. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..form of chronic inflammatory lung disease in preterm infants, is associated with the persistence of activated neutrophils in the lungs...
  34. Mechanisms of Inflammatory Lung Disease in Neonates
    Barry Weinberger; Fiscal Year: 2009
    ..form of chronic inflammatory lung disease in preterm infants, is associated with the persistence of activated neutrophils in the lungs...
  35. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2001
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including ..
  36. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2002
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including ..
  37. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2000
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including ..
  38. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2000
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including ..
  39. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 1999
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including ..
  40. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 1999
    ..The condition is marked by recruitment of inflammatory cells, in particular neutrophils, to the liver parenchyma. Once neutrophils invade the liver they can actively attack and destroy hepatocytes...
  41. CONTROL OF GRANULE TRANSLOCATION IN HUMAN NEUTROPHILS
    STEPHEN ROTHWELL; Fiscal Year: 1993
    ..When neutrophils are activated, their cytoplasmic granules are mobilized and transported to the plasma membrane for exocytosis ..
  42. CHEMOKINES AS MEDIATORS OF ALCOHOLIC LIVER INJURY
    JACQUELYN MAHER; Fiscal Year: 2000
    ..The condition is marked by recruitment of inflammatory cells, in particular neutrophils, to the liver parenchyma. Once neutrophils invade the liver they can actively attack and destroy hepatocytes...
  43. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2003
    Polymorphonuclear leukocytes, neutrophils, are the most abundant leukocytes in peripheral blood. They play a major role in innate immunity and may contribute to the development of the adaptive immune response...
  44. PHASE 2 & 3 TRIALS OF HIGH-DOSE ORAL N-ACETYLCYSTEINE IN CYSTIC FIBROSIS
    Carol Conrad; Fiscal Year: 2007
    ..Recently, the applicant observed that redox imbalance in CF also occurs intracellularly, in blood neutrophils, featuring low levels of reduced glutathione (GSH)...
  45. Role of DPPI & Serine Proteases in Inflammatory Diseases
    Christine Pham; Fiscal Year: 2005
    ..However, excessive accumulation and activation of neutrophils can lead to damaging effects...
  46. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    Polymorphonuclear leukocytes, neutrophils, are the most abundant leukocytes in peripheral blood. They play a major role in innate immunity and may contribute to the development of the adaptive immune response...
  47. BIOLOGY, IMMUNOLOGY & THERAPY OF ACANTHAMOEBA KERATITIS
    Hassan Alizadeh; Fiscal Year: 2009
    ..1) The innate immune system plays an important role in Acanthamoeba keratitis and polymorphonuclear neutrophils (PMN) are the prominent inflammatory cells in Acanthamoeba keratitis lesions;2) neutrophils are important in ..
  48. Vascular adhesion protein-1 (VAP-1) as a therapeutic target in stroke
    DALE ALAN PELLIGRINO; Fiscal Year: 2010
    ..e., neutrophils, monocytes, lymphocytes) in peripheral vascular beds...
  49. LIPID METABOLISM IN STIMULATED HUMAN PLATELETS
    M Broekman; Fiscal Year: 1990
    ..proposal is aimed at an understanding of the mechanisms by which resting and stimulated human platelets and neutrophils regulate levels of free arachidonate...
  50. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 2000
    Neutrophil sequestration and emigration in the lungs take place primarily in the capillaries. Rolling of neutrophils does not occur at this site, because most capillary segments are narrower than neutrophils...
  51. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 1999
    Neutrophil sequestration and emigration in the lungs take place primarily in the capillaries. Rolling of neutrophils does not occur at this site, because most capillary segments are narrower than neutrophils...
  52. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 2001
    Neutrophil sequestration and emigration in the lungs take place primarily in the capillaries. Rolling of neutrophils does not occur at this site, because most capillary segments are narrower than neutrophils...
  53. NEUTROPHIL SEQUESTRATION AND EMIGRATION IN THE LUNG
    CLAIRE DOERSCHUK; Fiscal Year: 1999
    Neutrophil sequestration and emigration in the lungs take place primarily in the capillaries. Rolling of neutrophils does not occur at this site, because most capillary segments are narrower than neutrophils...
  54. Analyses of neutrophil interaction with immune complexes
    Tanya Mayadas; Fiscal Year: 2009
    ..cooperated to promote IC induced neutrophil slow rolling, adhesion and transmigration, and TNF priming of neutrophils enhanced these processes...
  55. Mechanisms of neuronal injury during virus infection of the CNS
    CHARLES LEE HOWE; Fiscal Year: 2010
    ..infection of the CNS using the Theiler's murine encephalomyelitis virus to directly test the role of neutrophils in the initiation of neuronal apoptosis...
  56. Mechanisms of neuronal injury during virus infection of the CNS
    Charles Howe; Fiscal Year: 2009
    ..infection of the CNS using the Theiler's murine encephalomyelitis virus to directly test the role of neutrophils in the initiation of neuronal apoptosis...
  57. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2003
    ..IL-1, TNF, and MIP-2, and in activation of the transcriptional regulatory factors NF-kB and CREB in lung neutrophils. After endotoxemia, but not hemorrhage, adrenergic blockade increases expression of proinflammatory cytokines ..
  58. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2004
    ..IL-1, TNF, and MIP-2, and in activation of the transcriptional regulatory factors NF-kB and CREB in lung neutrophils. After endotoxemia, but not hemorrhage, adrenergic blockade increases expression of proinflammatory cytokines ..
  59. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2002
    ..IL-1, TNF, and MIP-2, and in activation of the transcriptional regulatory factors NF-kB and CREB in lung neutrophils. After endotoxemia, but not hemorrhage, adrenergic blockade increases expression of proinflammatory cytokines ..
  60. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2001
    ..IL-1, TNF, and MIP-2, and in activation of the transcriptional regulatory factors NF-kB and CREB in lung neutrophils. After endotoxemia, but not hemorrhage, adrenergic blockade increases expression of proinflammatory cytokines ..
  61. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2000
    ..IL-1, TNF, and MIP-2, and in activation of the transcriptional regulatory factors NF-kB and CREB in lung neutrophils. After endotoxemia, but not hemorrhage, adrenergic blockade increases expression of proinflammatory cytokines ..
  62. LUNG INFLAMMATION
    Gerald Weissmann; Fiscal Year: 1990
    b>Neutrophils mediate tissue injury in two classical models of experimental pathology: the Arthus lesion(1903) and the Shwartzman phenomenon (1927)...
  63. LUNG INFLAMMATION
    Gerald Weissmann; Fiscal Year: 1993
    b>Neutrophils mediate tissue injury in two classical models of experimental pathology: the Arthus lesion(1903) and the Shwartzman phenomenon (1927)...
  64. PMN ADHERENCE REACTIONS--ROLE IN CARDIOPULMONARY BYPASS
    William J Dreyer; Fiscal Year: 1991
    ..Recent experimental evidence suggests that neutrophils may be activated during cardiopulmonary bypass, perhaps due in part, to complement activation...
  65. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    ALBERT T HSU; Fiscal Year: 2010
    ..involved in the pathogenesis of ARDS and MOSF likely results from reactive oxygen species (ROS) produced by neutrophils. There currently exists a 2-hit model for the development of MOSF following sepsis and trauma...
  66. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    Albert Hsu; Fiscal Year: 2009
    ..involved in the pathogenesis of ARDS and MOSF likely results from reactive oxygen species (ROS) produced by neutrophils. There currently exists a 2-hit model for the development of MOSF following sepsis and trauma...
  67. MECHANISMS OF NEUTROPHIL DYSFUNCTION IN BURNS AND TRAUMA
    Joseph Solomkin; Fiscal Year: 1991
    ..There is convincing evidence that this syndrome is due to degranulation and oxidant production by neutrophils in the alveolar interstitium...
  68. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD O DONNELL; Fiscal Year: 2009
    ..NSPs) (elastase, cathepsin G and proteinase-3) released at inflammatory sites by degranulating or necrotic neutrophils are major contributors to the pathology of cystic fibrosis and chronic obstructive pulmonary disease (COPD)...
  69. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
    ..NSPs) (elastase, cathepsin G and proteinase-3) released at inflammatory sites by degranulating or necrotic neutrophils are major contributors to the pathology of cystic fibrosis and chronic obstructive pulmonary disease (COPD)...
  70. ROLE OF CD11B/CD18 AND NEUTROPHIL/EPITHELIAL INTERACTION
    CHARLES PARKOS; Fiscal Year: 1999
    A wide variety of human diseases, in their active stages, are characterized by migration of neutrophils across mucosal surfaces...
  71. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2006
    ..The cause of preeclampsia is not known. We propose that increased levels of lipid peroxides (LOOH) activate neutrophils, as well as endothelial and vascular smooth muscle cells, resulting in the elaboration of the neutrophil ..
  72. NEUTROPHILS & ACUTE INFLAMMATORY RESPONSES TO TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 1999
    Secondary processes exacerbate brain injury after trauma. Recent studies suggest that neutrophils in the local acute inflammatory response to traumatic brain injury contribute to this process, however, their role remains largely ..
  73. Histamine and Neutrophil Influx in the Pathogenesis of Acute Lung Injury
    CRAIG ALEXANDER SMUDA; Fiscal Year: 2010
    ..The influx of neutrophils in response to the initiating stimuli of ALI is a hallmark of the pathologic process and a major contributor to ..
  74. Histamine and Neutrophil Influx in the Pathogenesis of Acute Lung Injury
    Craig Smuda; Fiscal Year: 2009
    ..The influx of neutrophils in response to the initiating stimuli of ALI is a hallmark of the pathologic process and a major contributor to ..
  75. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2007
    ..The cause of preeclampsia is not known. We propose that increased levels of lipid peroxides (LOOH) activate neutrophils, as well as endothelial and vascular smooth muscle cells, resulting in the elaboration of the neutrophil ..
  76. Oxidant Stress Mechanisms in Preeclampsia
    Scott Walsh; Fiscal Year: 2003
    ..The cause of preeclampsia is not known. We propose that increased levels of lipid peroxides (LOOH) activate neutrophils, as well as endothelial and vascular smooth muscle cells, resulting in the elaboration of the neutrophil ..
  77. Research Training in Epigenetics of Premature Labor, Progresterone Receptor Expre
    JOHN NESTLER; Fiscal Year: 2007
    ..include: 1) Neutrophil induced epigenetic changes in vascular smooth muscle genes: the aim is to determine if neutrophils or neutrophil products (ROS, TNF??) can induce epigenetic changes in vascular smooth muscle genes related to ..