Genomes and Genes
Summary: Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.
Publications233 found, 100 shown here
- Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cellsJerome E Lee
Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
PLoS ONE 5:e11201. 2010..Moreover, just as transcription factor activity varies between different cell types, the factors influencing mRNA decay are also cell-type specific...
- Bone marrow stromal cells generate muscle cells and repair muscle degenerationMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
Science 309:314-7. 2005..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
- Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cellsSandro M Hirabara
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Butanta, Sao Paulo, Brazil
J Cell Physiol 222:187-94. 2010..Primary cultures of rat skeletal muscle cells exhibited similar responses to saturated FFA as compared to C2C12 cells...
- Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and εGirish Kewalramani
Cell Biology Program, The Hospital for Sick Children, Toronto, Canada
PLoS ONE 6:e26947. 2011..conditioned medium from macrophages treated with palmitate (CM-PA) reduces insulin action and glucose uptake in muscle cells. However, the mechanism whereby CM-PA confers this negative response onto muscle cells remains unknown.
- Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cellsHenrike Sell
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
Diabetes 58:2731-40. 2009..This study was aimed at investigating the regulation of chemerin release and its effects on glucose metabolism in skeletal muscle cells.
- Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cellsNikolaos Dimopoulos
Division of Molecular Physiology, Centre for Interdisciplinary Research, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem J 399:473-81. 2006..of palmitoleate (a MUFA) and palmitate (a SFA) on insulin action and glucose utilization in rat L6 skeletal muscle cells. Basal glucose uptake was enhanced approx. 2-fold following treatment of cells with palmitoleate...
- Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythmHiromitsu Negoro
Department of Urology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606 8507, Japan
Nat Commun 3:809. 2012..Bladder muscle cells have an internal clock, and show oscillations of connexin43 and gap junction function...
- Primary skeletal muscle cells trigger spontaneous Toxoplasma gondii tachyzoite-to-bradyzoite conversion at higher rates than fibroblastsMarialice da Fonseca Ferreira-da-Silva
Institute for Medical Microbiology, Georg August University, Kreuzbergring 57, 37075 Gottingen, Germany
Int J Med Microbiol 299:381-8. 2009..Here, we have followed the transition of tachyzoites to bradyzoites after infection of skeletal muscle cells (SkMC)...
- Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cellsValentina Guasconi
Institut Andre Lwoff, Centre National de la Recherche Scientifique CNRS, FRE2944, Universite Paris Sud, Villejuif, France
Epigenetics 5:704-9. 2010....
- Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cellsJulia Sacher
Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Austria
J Pharmacol Exp Ther 314:1032-41. 2005..Here, we show that statins cause apoptosis in differentiated human skeletal muscle cells. The prototypical representative of statins, simvastatin, triggered sustained intracellular Ca(2+) transients, ..
- Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin-mediated myogenesisPatrycja Pawlikowska
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
Cell Prolif 39:127-45. 2006Viability and myogenesis from C2C12 muscle cells and L6 rat myoblasts were dose-dependently stimulated by insulin...
- Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cellsCeline Aguer
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada
PLoS ONE 6:e28536. 2011....
- Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cellsS Famulla
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
Int J Obes (Lond) 35:762-72. 2011..The aim of this study was to investigate the regulation and autocrine function of PEDF in human adipocytes and to determine its paracrine effects on human skeletal muscle cells (hSkMC) and human smooth muscle cells (hSMC).
- Mesoangioblast stem cells ameliorate muscle function in dystrophic dogsMaurilio Sampaolesi
San Raffaele Scientific Institute, Universita Vita e Salute, Stem Cell Research Institute, Via Olgettina 58, 20132 Milan, Italy
Nature 444:574-9. 2006..The outcome is a remarkable clinical amelioration and preservation of active motility. These data qualify mesoangioblasts as candidates for future stem cell therapy for Duchenne patients...
- Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength trainingFrode Norheim
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
Am J Physiol Endocrinol Metab 301:E1013-21. 2011..Our aim was to identify the most abundantly secreted proteins in cultures of human skeletal muscle cells and to monitor their expression in muscles of strength-training individuals...
- Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cellsT Andrienko
Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
J Exp Biol 206:2059-72. 2003..Inside these complexes, mitochondrial functional state is controlled by channeling of ADP, mostly via energy- and phosphoryl-transfer networks, and apparently depends on the state of sarcomere structures...
- Interactions between neutrophils and macrophages promote macrophage killing of rat muscle cells in vitroHal X Nguyen
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
J Physiol 547:125-32. 2003..In the present investigation, interactions between neutrophils, macrophages and muscle cells that may influence muscle cell death are examined...
- Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signalingAnindita Das
Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0281, USA
J Biol Chem 280:12944-55. 2005..The results may have possible therapeutic potential in preventing myocyte cell death following ischemia/reperfusion...
- USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cellsPriyanka Sundaram
Department of Medicine, Polypeptide Laboratory, McGill University and the McGill University Health Centre Research Institute, Montreal, Canada
Am J Physiol Endocrinol Metab 297:E1283-90. 2009..To further explore the role of USP19, we used small interfering RNA (siRNA) in L6 muscle cells. Lowering USP19 by 70-90% in myotubes resulted in a 20% decrease in the rate of proteolysis and an 18% decrease ..
- Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytesKeiichi Fukuda
Institute for Advanced Cardiac Therapeutics, Institute of Integrated Medical Research 7S1 7S2, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
C R Biol 325:1027-38. 2002..These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future...
- High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cellsQichun Zhang
Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing, People s Republic of China
PLoS ONE 6:e23556. 2011..This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells.
- Ear mesenchymal stem cells (EMSC) can differentiate into spontaneously contracting muscle cellsBarbara Gawronska-Kozak
Regenerative Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
J Cell Biochem 102:122-35. 2007..markers (CD44, CD73) and stem cell marker Sca-1 and can be differentiated into spontaneously contracting muscle cells. Treatment of cells with epidermal growth factor (EGF) change their morphology from fibroblast shapes into ..
- High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitusBrian G Drew
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Circulation 119:2103-11. 2009..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
- Protection of dystrophic muscle cells with polyphenols from green tea correlates with improved glutathione balance and increased expression of 67LR, a receptor for (-)-epigallocatechin gallateOlivier M Dorchies
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
Biofactors 35:279-94. 2009..Altogether our results demonstrate that GTP and EGCg protect muscle cells by scavenging H(2)O(2) and by improving the glutathione balance...
- Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase IIJerry Curran
Rush University, Chicago, IL, USA
J Mol Cell Cardiol 49:25-32. 2010..Treatment with ISO plus KN93 completely abolished this effect. The evidence suggests the ISO-dependent increase in SCaW activity in both healthy and failing myocytes is CaMKII-dependent, implicating CaMKII in arrhythmogenesis...
- Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-betaVasso Terzidou
Parturition Research Group, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Du Cane Road, East Acton, London W12 ONN, United Kingdom
J Clin Endocrinol Metab 91:2317-26. 2006....
- Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individualsLeslie A Consitt
Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, USA
Diabetes 59:1407-15. 2010To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of ..
- A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dyeTetsuaki Miyake
Department of Physiology, University of Toronto, Best Institute Medical Research, Toronto, Canada
PLoS ONE 6:e28628. 2011Identification of differentiating muscle cells generally requires fixation, antibodies directed against muscle specific proteins, and lengthy staining processes or, alternatively, transfection of muscle specific reporter genes driving GFP ..
- Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial InteractosomeRita Guzun
Inserm U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
Biochim Biophys Acta 1818:1545-54. 2012..blot analysis we have shown that β2-tubulin coexpressed with mitochondria is highly important for cardiac muscle cells mitochondrial metabolism. Since it has been shown by Rostovtseva et al...
- Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cellsPing Liu
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
J Physiol 589:101-17. 2011..elegans body-wall myocytes generate all-or-none APs, which evoke Ca2+ release from the sarcoplasmic reticulum (SR), although the specific ion channels used for AP upstroke and repolarization differ...
- Wnt proteins regulate acetylcholine receptor clustering in muscle cellsBin Zhang
Department of Neurology and Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Mol Brain 5:7. 2012The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses...
- Canonical TRP channels and mechanotransduction: from physiology to disease statesAmanda Patel
IPMC CNRS, Universite de Nice Sophia Antipolis, 660 route des Lucioles, 06560, Valbonne, France
Pflugers Arch 460:571-81. 2010..For instance, opening of the non-selective stretch-activated cation channels in smooth muscle cells is involved in the pressure-dependent myogenic constriction of resistance arteries...
- Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cellsSusan M Krzysik-Walker
Department of Poultry Science, The Pennsylvania State University, University Park, PA 16802, USA
Comp Biochem Physiol A Mol Integr Physiol 159:413-21. 2011..mL(-1)) decreased Nampt mRNA abundance. Collectively, these results demonstrate that Nampt, regulated in part by IL-6, alters the expression of key myogenic transcription factors and thereby may influence postnatal myogenesis...
- Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegansAndreas M Gaiser
Department of Chemistry and Center for Integrated Protein Science Munich CIPSM and Technische Universität München, Munchen, Germany
PLoS ONE 6:e25485. 2011..Furthermore, aggregates of the myosin MYO-3 are visible in muscle cells, if DAF-21 is depleted, implying a role of Hsp90 in the maintenance of muscle cell functionality...
- FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C₂C₁₂ muscle cellsMargarete Digel
Molecular Cell Biology Laboratory Internal Medicine IV, University of Heidelberg, Heidelberg, Germany
Am J Physiol Endocrinol Metab 301:E785-96. 2011..Here, we investigated the function of FATP4 in basal and insulin mediated fatty acid uptake in C(2)C(12) muscle cells, a model system relevant for fatty acid metabolism...
- Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stressR Vinayaga Moorthi
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
Clin Chim Acta 367:132-6. 2006The effect of reactive oxygen species (ROS) on insulin action is unclear. This study was carried out to explore the effect of prolonged low grade oxidative stress and vitamin E treatment on cultured rat L6 muscle cells.
- [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]J Neuhaus
Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
Urologe A 46:1193-7. 2007..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells.
- Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolismR Han
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, 200031, China
Diabetologia 50:1960-8. 2007..However, it is unknown whether APOA-I directly protects against diabetes. The aim of this study was to characterise the functional role of APOA-I in glucose homeostasis...
- Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsTim Ting Chiu
Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
Mol Biol Cell 21:3529-39. 2010..We propose that Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
- TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cellsChristian W Keller
Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
J Biol Chem 286:3970-80. 2011....
- Nuclei of non-muscle cells bind centrosome proteins upon fusion with differentiating myoblastsXavier Fant
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 4:e8303. 2009..Concomitantly, proteins of the centrosome relocalize from the pericentriolar material to the outer surface of the nucleus. The mechanisms that govern this relocalization are largely unknown...
- Quantification of rapid Myosin regulatory light chain phosphorylation using high-throughput in-cell Western assays: comparison to Western immunoblotsHector N Aguilar
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 5:e9965. 2010....
- Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cellsYi Sun
Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Proc Natl Acad Sci U S A 107:19909-14. 2010..Intriguingly, the AS160-targeted Rabs appear to differ, with Rab8A participating in GLUT4 exocytosis in muscle cells and Rab10 in adipocytes, and their activation by insulin is unknown...
- Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacitiesKarine Vauchez
Inserm U974, Paris, France
Mol Ther 17:1948-58. 2009..Our results suggest that ALDH activity is a novel marker for a population of new human skeletal muscle progenitors presenting a potential for cell biology and cell therapy...
- Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytesJeffrey G Jacot
Department of Bioengineering, University of California, San Diego, USA
Biophys J 95:3479-87. 2008..On very stiff substrates, this adaptation seems to involve RhoA kinase...
- AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cellsIsabella Irrcher
Department of Biology, York University, Toronto, Ontario, Canada
PLoS ONE 3:e3614. 2008..Our data identify a novel AMPK-mediated regulatory pathway that regulates PGC-1alpha gene expression. This could represent a potential therapeutic target to control PGC-1alpha expression in skeletal muscle...
- Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activityRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Shock 32:416-26. 2009..of the present study was to test the hypothesis that endogenous NO negatively affects translation in skeletal muscle cells after exposure to a combination of endotoxin (LPS) and interferon-gamma (IFN-gamma)...
- K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblastsL Chilton
Dept of Bioengineering, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 288:H2931-9. 2005..In combination, these results show that ventricular fibroblasts and myofibroblasts express a variety of K(+) channel alpha-subunits and demonstrate that Kir current can modulate RMP and alter essential physiological functions...
- Porcine peroxisome proliferator-activated receptor gamma induces transdifferentiation of myocytes into adipocytesY H Yu
Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan
J Anim Sci 84:2655-65. 2006..Therefore, the existence of serine 112 in PPARgamma may have a role in regulating adipocyte differentiation...
- Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cellsRussell Hyde
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, UK
FASEB J 19:461-3. 2005..attenuate the basal and insulin-stimulated activity of the Na+-dependent System A amino acid transporter in rat muscle cells (L6 myotubes) by depletion of the plasma membrane abundance of SNAT2 (a System A isoform)...
- Leptin expression in human primary skeletal muscle cells is reduced during differentiationRigmor Solberg
Department of Pharmacology, School of Pharmacy, University of Oslo, Oslo, Norway
J Cell Biochem 96:89-96. 2005..However, the expression of the leptin receptor (OB-Rb) mRNA, was unchanged during differentiation of the muscle cells. Administration of recombinant leptin had no effect on leptin, myogenin, myoD, or GLUT4 mRNA expressions during ..
- The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic proteinValeria Kowaljow
Laboratorio de Neurogenética, Instituto de Investigacion, Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
Neuromuscul Disord 17:611-23. 2007..Overexpression of DUX4 induces cell death, induces caspase 3/7 activity and alters emerin distribution at the nuclear envelope. We propose that DUX4-mediated cell death contributes to the pathogenic pathway in FSHD...
- Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulationAthanassia Sotiropoulos
Institut National de la Sante et de la Recherche Medicale, U810, and Faculté de Médecine Necker Enfants Malades, Universite Paris 5, F 75730 Paris, France
Proc Natl Acad Sci U S A 103:7315-20. 2006..Taken together, these data unravel a specific function of GH in the control of cell fusion, an essential process for muscle growth...
- Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicityJerrod W Hunter
Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Dis Model Mech 3:366-76. 2010..Our results suggest a possible link between genetic defects in synapse formation or function, and sensitivity to environmental factors in the development of autism spectrum disorders...
- Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: application to detection of translocated glucose transporter 4 on the plasma membraneShin Nishiumi
Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe, Hyogo 657 8501, Japan
Biosci Biotechnol Biochem 71:2343-6. 2007The aim of this study was to establish a rapid preparation of plasma membrane from adipocytes and muscle cells to detect translocated glucose transporter (GLUT) 4...
- AMP-activated protein kinase and the regulation of glucose transportNobuharu Fujii
Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Physiol Endocrinol Metab 291:E867-77. 2006..The identification of AMPK as a novel glucose transport mediator in skeletal muscle is providing important insights for the treatment and prevention of type 2 diabetes...
- Oxidative stress-associated mitochondrial dysfunction in corticosteroid-treated muscle cellsYasushi Oshima
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Muscle Nerve 30:49-54. 2004..Since these changes disappeared in the presence of SOD, dexamethasone primarily induced ROS generation, resulting in apoptosis. We speculate that this mechanism provides the basis of a pathophysiological model of corticosteroid myopathy...
- Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandinsM Sussmann
Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Germany
Circ Res 94:592-600. 2004..The regulation of HA synthesis by vasodilatory prostaglandins was analyzed in human arterial smooth muscle cells (SMCs)...
- Simultaneous imaging and functional assessment of cytoskeletal protein connections in passively loaded single muscle cellsSameer B Shah
Department of Bioengineering, Biomedical Sciences Graduate Group, University of California and Veterans Administration Medical Centers, San Diego, California 92161, USA
J Histochem Cytochem 51:19-29. 2003..We demonstrated in sample wild-type muscle cells that there was significant connectivity among Z-disks in the same fiber at various sarcomere lengths, as well ..
- Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanismsChangkeun Kang
College of Veterinary Medicine, Gyeongsang National University, Jinju 660 701, South Korea
Food Chem 135:2350-8. 2012..saffron through investigating its signaling pathways associated with glucose metabolism in C(2)C(12) skeletal muscle cells. Saffron strongly enhanced glucose uptake and the phosphorylation of AMPK (AMP-activated protein kinase)/ACC (..
- Rac1 signalling towards GLUT4/glucose uptake in skeletal muscleTim T Chiu
Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada
Cell Signal 23:1546-54. 2011..actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle...
- Transgene expression in mononuclear muscle cells not infiltrating inflammatory cells following intramuscular plasmid gene electrotransferJarupa Ratanamart
Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, UK
J Gene Med 12:377-84. 2010..Expression of the transgene in non-muscle cells may increase the immune response...
- α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cellsBojun Chen
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
EMBO J 29:3184-95. 2010..required for subcellular localization of SLO-1, the Caenorhabditis elegans BK channel α-subunit, in body-wall muscle cells. CTN-1 was identified in a genetic screen for mutants that suppressed a lethargic phenotype caused by ..
- Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile responseMargaret V Westfall
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 280:41324-31. 2005....
- Immortalized skin fibroblasts expressing conditional MyoD as a renewable and reliable source of converted human muscle cells to assess therapeutic strategies for muscular dystrophies: validation of an exon-skipping approach to restore dystrophin in DuchenSoraya Chaouch
Universite Pierre et Marie Curie Paris 06, UMRS 974, Paris F 75013, France
Hum Gene Ther 20:784-90. 2009..Cellular models seem straightforward to set up; however, the proliferative capacity of muscle cells isolated from dystrophic patients is limited, and in addition it is difficult to envisage the use of large ..
- Insulin-like growth factor-I-induced androgen receptor activation is mediated by the PI3K/Akt pathway in C2C12 skeletal muscle cellsWon Jun Lee
Department of Exercise Science, College of Health Sciences, Ewha Womans University, Seoul 120 750, Korea
Mol Cells 28:495-9. 2009..of skeletal muscle, the molecular mechanism by which signaling pathways integrating AR and IGF-I in skeletal muscle cells has not been previously examined...
- Regulation of VEGF and bFGF mRNA expression and other proliferative compounds in skeletal muscle cellsL Jensen
Copenhagen Muscle Research Centre, Institute of Exercise and Sport Science, University of Copenhagen, Copenhagen, Denmark
Angiogenesis 7:255-67. 2004..effect of extracellular medium was determined in non-stimulated and electro-stimulated rat and human skeletal muscle cells. In rat skeletal muscle cells these aspects were also determined after treatment with inhibitors and/or donors ..
- Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and adipocytesRosanna Cazzolli
Department of Medicine, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Methods Mol Biol 462:241-51. 2009..cellular PLD activity in secretagogue-stimulated insulin-secreting pancreatic beta-cells and also insulin-stimulated adipocyte and muscle cells, two of the principal insulin-responsive cell types controlling blood glucose levels.
- Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1Paola Ungaro
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
J Biol Chem 287:42951-61. 2012..Thus, ped/pea-15 is downstream of a major PPARγ-regulated inflammatory network. Repression of ped/pea-15 transcription might contribute to the PPARγ regulation of muscle sensitivity to insulin...
- Titin/connectin-related proteins in C. elegans: a review and new findingsTracey M Ferrara
Department of Pathology, Emory University, Atlanta, GA 30322, USA
J Muscle Res Cell Motil 26:435-47. 2005
- 18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesisKeitaro Yamanouchi
Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Tokyo, Japan
Cell Physiol Biochem 20:781-90. 2007The importance of connexins is implicated in proliferation and differentiation of cells. In skeletal muscle cells, connexin43 (Cx43) has been identified as the major connexin, and gap-junctional communication mediated by connexins has ..
- Morphological effects of myasthenia gravis patient sera on human muscle cellsSteven Paul Luckman
Institute of Clinical Medicine, Section for Neurology, University of Bergen and Haukeland University Hospital, N5021 Bergen, Norway
Muscle Nerve 33:93-103. 2006..of different autoantibody composition and obtained at different stages of disease severity, on primary human muscle cells. Sera from MG patients induced changes in cell morphology from typical elongated cells to an irregular ..
- Utrophin is a calpain substrate in muscle cellsIsabelle Courdier-Fruh
Santhera Pharmaceuticals, Hammerstrasse 25, CH 4410 Liestal, Switzerland
Muscle Nerve 33:753-9. 2006..In this study, we investigated the susceptibility of utrophin to cleavage by calpain in vitro and in muscle cells. We found that utrophin is a direct in vitro substrate of purified calpain I and II...
- Glucosamine-induced insulin resistance in L6 muscle cellsC J Bailey
School of Life and Health Sciences, Aston University, Birmingham, UK
Diabetes Obes Metab 6:293-8. 2004..Glucosamine increases flux through the hexosamine pathway, causing insulin resistance and disturbances similar to diabetic glucose toxicity...
- Expression of a Clostridium perfringens type IV pilin by Neisseria gonorrhoeae mediates adherence to muscle cellsKatherine Rodgers
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
Infect Immun 79:3096-105. 2011..These findings implicate C. perfringens TFP in the ability of C. perfringens to adhere to and move along muscle fibers in vivo, which may provide a therapeutic approach to limiting this rapidly spreading and highly lethal infection...
- An enhancer required for transcription of the Col6a1 gene in muscle connective tissue is induced by signals released from muscle cellsPaola Braghetta
Department of Histology Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
Exp Cell Res 314:3508-18. 2008..In face of the large body of work highlighting the relevance for human diseases of the adhesion of muscle cells with their surrounding extracellular matrix, remarkably little is known on how myogenic cells control gene ..
- Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cellsYoussef Hibaoui
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, Quai Ernest Ansermet, Geneva, Switzerland
J Pineal Res 47:238-52. 2009..In conclusion, our findings suggest that inhibition of the PTP essentially contributes to the protective effect of melatonin against oxidative stress in myotubes...
- Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cellsJung Ok Lee
Department of Anatomy, Korea University College of Medicine, Seoul, Korea
J Cell Physiol 226:974-81. 2011..Unlike Rab4ΔCT, wild-type Rab4 co-localized with PKC-zeta. Together, these results demonstrate that metformin induces Rab4 expression via AMPK-AS160-PKC-zeta and modulates insulin-mediated GLUT4 translocation...
- Lectin-like oxidized LDL receptor-1 (LOX-1) acts as a receptor for remnant-like lipoprotein particles (RLPs) and mediates RLP-induced migration of vascular smooth muscle cellsYo Aramaki
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
Atherosclerosis 198:272-9. 2008..in atherogenesis especially by diabetic dyslipidemia; however, their receptor(s) and effects on vascular smooth muscle cells (VSMCs) remain unclear...
- Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone conditionZ F Zhang
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China
Phytomedicine 17:14-8. 2010..Furthermore, we also demonstrated these EGCG effects essentially depended on the AMPK and Akt activation. Together, our data suggested that EGCG inhibited dexamethasone-induced insulin resistance through AMPK and PI3K/Akt pathway...
- Genetic complementation of human muscle cells via directed stem cell fusionManuel A F V Gonçalves
Virus and Stem Cell Biology Laboratory, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Mol Ther 16:741-8. 2008..whether human mesenchymal stem cells (hMSCs) can serve as donors of recombinant DMD genes for recipient human muscle cells. Here, we show that forced MyoD expression in hMSCs greatly increases their tendency to participate in human ..
- Differentiation-induced radioresistance in muscle cellsLucia Latella
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
Mol Cell Biol 24:6350-61. 2004....
- Subcellular localization of fukutin and fukutin-related protein in muscle cellsHiroshi Matsumoto
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
J Biochem 135:709-12. 2004..Our data suggest that fukutin and FKRP may be involved at different steps in O-mannosylglycan synthesis of alpha-dystroglycan, and FKRP is most likely involved in the initial step in this synthesis...
- Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humansCostas A Anastasiou
Department of Dietetics and Nutrition, Laboratory of Nutrition and Clinical Dietetics, Harokopio University, 17671 Athens, Greece
Metabolism 58:1636-42. 2009..The total flux of fatty acids toward esterification may be a much more important factor in the pathophysiology of diabetes...
- Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cellsHiroki Sugita
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Shriners Hospital for Children, Harvard Medical School, Boston, Massachusetts 02129, USA
J Biol Chem 280:14203-11. 2005..insulin receptor substrate (IRS)-1 protein expression without altering the mRNA level in cultured skeletal muscle cells. NO donor increased IRS-1 ubiquitination, and proteasome inhibitors blocked NO donor-induced reduction in IRS-1 ..
- Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cellsChandrasagar B Dugani
Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
Eur J Cell Biol 87:337-51. 2008..We propose that insulin causes selective, dynamic relocalization of perinuclear GLUT4myc and VAMP2 and perinuclear GLUT4myc redistribution is a direct target of insulin-derived signals...
- Transfer of the full-length dystrophin-coding sequence into muscle cells by a dual high-capacity hybrid viral vector with site-specific integration abilityManuel A F V Gonçalves
Gene Therapy Section, Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
J Virol 79:3146-62. 2005..Dual hcAd/AAV hybrid vectors may thus be particularly useful to develop safe treatment modalities for diseases such as DMD that rely on efficient transfer and stable expression of large genes...
- Oestradiol and SERM treatments influence oestrogen receptor coregulator gene expression in human skeletal muscle cellsC M Dieli-Conwright
Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, Los Angeles, CA, USA
Acta Physiol (Oxf) 197:187-96. 2009..We investigated the influence of oestradiol and selective ER modulators [tamoxifen (TAM), raloxifene (RAL)] on ER coregulator mRNA expression in hSkM...
- Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cellsSung Soo Chung
Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
Mol Cell Biol 29:20-30. 2009..Here, we show that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling...
- Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocationShuhei Ishikura
Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
Am J Physiol Cell Physiol 295:C1016-25. 2008..Moreover, there is controversy as to the AS160/TBC1D1 target Rabs in fat and muscle cells, and Rab effectors are unknown...
- Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cellsVigdis Aas
Faculty of Health Sciences, Oslo University College, Oslo, Norway
J Lipid Res 47:366-74. 2006..the chronic effects of eicosapentaenoic acid (EPA) on fatty acid and glucose metabolism in human skeletal muscle cells. Uptake of [14C]oleate was increased >2-fold after preincubation of myotubes with 0...
- Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complexTakeshi Hashimoto
Exercise Physiology Laboratory, Dept of Integrative Biology, 5101 Valley Life Sciences Bldg, Univ of California, Berkeley, CA 94720 3140, USA
Am J Physiol Endocrinol Metab 290:E1237-44. 2006....
- UV-embossed microchannel in biocompatible polymeric film: application to control of cell shape and orientation of muscle cellsJin Ye Shen
The Biological and Chemical Process Engineering Laboratory, School of Mechanical and Aerospace Engineering, 50 Nanyang Avenue, Singapore 639798
J Biomed Mater Res B Appl Biomater 77:423-30. 2006..The effect of the micropatterns on A7r5 smooth muscle cells and C2C12 skeletal muscle cells was investigated...
- A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cellsGrazia Camarda
Depatment of Environment and Primary Prevention, Higher Institute of Health, 00161 Roma, Italy
J Cell Biol 167:417-23. 2004..Here, we show that terminal proliferation arrest is maintained in skeletal muscle cells by a pRb-independent mechanism...
- Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiencyTimothy R Koves
Department of Medicine, and Sarah W Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 280:33588-98. 2005..We proposed that PGC1alpha enables muscle mitochondria to better cope with a high lipid load, possibly reflecting a fundamental metabolic benefit of exercise training...
- Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMPVarinder K Randhawa
Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Mol Biol Cell 15:5565-73. 2004Insulin and hypertonicity each increase the content of GLUT4 glucose transporters at the surface of muscle cells. Insulin enhances GLUT4 exocytosis without diminishing its endocytosis...
- Neuregulin signaling on glucose transport in muscle cellsCarles Canto
Departament de Bioquímica i Biologia Molecular and Parc Científic de Barcelona, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
J Biol Chem 279:12260-8. 2004..induces glucose transport through translocation of glucose transporters, in an additive manner to insulin, in muscle cells. In this study, we examined the signaling pathway required for a recombinant active neuregulin-1 isoform (..
- The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is depeLeonardo R Silveira
Institute of Biomedical Sciences, Department of Physiology and Biophysics, University of Sao Paulo, Sao Paulo, SP, Brazil
Biochim Biophys Acta 1763:969-76. 2006..Rat skeletal muscle cells were subjected to acute or repeated electrostimulation in the presence and absence of antioxidants...
- Restoration of dystrophin expression in mdx muscle cells by chimeraplast-mediated exon skippingCarmen Bertoni
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
Hum Mol Genet 12:1087-99. 2003..Such mutations generally lead to a complete absence of dystrophin protein in the muscle cells of affected individuals...
- Swelling-activated chloride channels in cardiac physiology and pathophysiologyClive M Baumgarten
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0551, USA clive baumgarten vcu edu
Prog Biophys Mol Biol 82:25-42. 2003..I(Cl,swell) plays a role in arrhythmogenesis, myocardial injury, preconditioning, and apoptosis of myocytes. As a result, I(Cl,swell) potentially is a novel therapeutic target...
- Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cellsHarold Couchoux
University Lyon 1, CNRS, Laboratory of Integrative, Cellular and Molecular Physiology, Villeurbanne, F 69622, France
J Physiol 580:745-54. 2007..results suggest that Cav-3 is involved in L-type Ca(2+) channel membrane function and localization in skeletal muscle cells and that an alteration of L-type Ca(2+) channels could be involved in the physiopathological mechanisms of ..
Research Grants152 found, 100 shown here
- Dynamics of Oxygen Uptake in Contracting Single MyocytesCASEY KINDIG; Fiscal Year: 2003..abstract_text> ..
- Bi-directional Calcium Signaling in Striated MusclesJianjie Ma; Fiscal Year: 2007In striated muscle cells, the transverse tubular (TT) invagination of plasma membrane contacts the terminal cisternae of sarcoplasmic reticulum (S...
- Store-Operated Calcium Entry and ApoptosisJianjie Ma; Fiscal Year: 2007..Knowledge on the molecular interactions between apoptosis mediators and cytosolic factors that control SOCE will enable us to establish therapeutic agents that target Ca signaling in cancer and degenerative diseases. ..
- RYANODINE RECEPTOR OF E/C COUPLING IN STRIATED MUSCLESJianjie Ma; Fiscal Year: 2001The ryanodine receptor (RyR) is an essential component of excitation- contraction (E-C) coupling in striated muscle cells, whereby a depolarization across the transverse tubule (TT) membrane leads to rapid release of Ca from the ..
- Ca Sparks in Muscle Aging and DystrophyJianjie Ma; Fiscal Year: 2007Ca sparks are the elementary units of Ca-induced Ca release (CICR) in striated muscle cells revealed as localized Ca release events from sarcoplasmic reticulum (SR) by confocal microscopy...
- High fat feeding and intramyocellular lipid abnormalityZengKui Guo; Fiscal Year: 2005..Thus, the proposed research will improve the understanding of the mechanism of insulin resistance and imcTG abnormalities in the obese rat that will benefit investigation of human obesity. ..
- Bidirectional Ca Signaling Between Cell Surface and InraJianjie Ma; Fiscal Year: 2005..project is to understand the cellular and molecular function of these novel JP genes in the Ca signaling of muscle cells, specifically to test the hypothesis that JP plays important roles in the ultrastructural arrangement of the ..
- RECONSTITUTION OF CFTR CHLORIDE CHANNELJianjie Ma; Fiscal Year: 2004..Fulfillment of the experiments proposed in this project should provide further insights into the function and regulation of the CFTR Cl- channel, as well as the potential therapeutic interventiosn in cystic fibrosis. ..
- Role of MG29 in E-C Coupling of Striated MusclesJianjie Ma; Fiscal Year: 2006..long term goal of this project is to understand the cellular and molecular function of MG29 in E-C coupling of muscle cells, specifically to test the hypothesis that MG29 is a key protein involved in the biogenesis of the T-tubule ..
- Calcium Signaling and Cytochrome C Release in ApoptosisJianjie Ma; Fiscal Year: 2005..Our long term goal of this project is to understand the cellular and molecular mechanism of Ca signaling in apoptosis, and to provide alternative interventions in the therapy of prostate cancer. ..
- Bi-directional Calcium Signaling in Striated MusclesJianjie Ma; Fiscal Year: 2010In striated muscle cells, the transverse tubular (TT) invagination of plasma membrane contacts the terminal cisternae of sarcoplasmic reticulum (S...
- Store-Operated Calcium Entry and ApoptosisJianjie Ma; Fiscal Year: 2010..Knowledge on the molecular interactions between apoptosis mediators and cytosolic factors that control SOCE will enable us to establish therapeutic agents that target Ca signaling in cancer and degenerative diseases. ..
- RECONSTITUTION OF CFTR CHLORIDE CHANNELJianjie Ma; Fiscal Year: 2000..In addition, the studies may lead to engineering of CFTR channels with higher activity, which will be useful for high efficiency gene therapy for CF. ..
- TRIC, a Novel Modulator of Intracellular Ca HomeostasisJianjie Ma; Fiscal Year: 2010..For efficient operation of excitation-contraction coupling in muscle cells, or excitation-secretion coupling in non-muscle cells, counter ion movement across the SR or ER membrane must ..
- Ca Sparks in Muscle Aging and DystrophyJianjie Ma; Fiscal Year: 2010Ca sparks are the elementary units of Ca-induced Ca release (CICR) in striated muscle cells revealed as localized Ca release events from sarcoplasmic reticulum (SR) by confocal microscopy...
- Actions of Ethanol on Ligand-Gated Ion ChannelsGustav Akk; Fiscal Year: 2006..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
- SUMMER RESEARCH PROGRAM FOR MINORITY MEDICAL STUDENTSDonald Menick; Fiscal Year: 2007....
- SPECT MAMMOGRAPHY USING ROTATING SLANT HOLE COLLIMATORSTEPHEN KNISLEY; Fiscal Year: 2001..It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer. ..
- Trypanosoma cruzi and AIDS: Role of the AdipocyteHerbert Tanowitz; Fiscal Year: 2007....
- Mechanisms regulating SR Ca2+ ATPase in the AtriaMuthu Periasamy; Fiscal Year: 2010..These studies will employ genetically engineered mouse models to understand if loss of Sarcolipin protein has an effect on cardiac function. ..
- The ER Stress Response and ATF6 Activation in the HeartCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
- Novel epoxide hydrolase inhibitor for stroke preventionJOHN IMIG; Fiscal Year: 2005..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
- Role of the Unfolded Protein Response in Cardiac ProtectionChristopher C Glembotski; Fiscal Year: 2010Long-term Objective: Our long-term objective is to elucidate biochemical reactions in heart muscle cells that protect them from damaging stresses, such as deprivation of oxygen and nutrients...
- Sleep deprivation and energy balanceMarie Pierre St Onge; Fiscal Year: 2010..This study will examine how food intake and energy expenditure can be modified by sleep duration as a means of understanding a potential causal pathway. ..
- Breast Cancer and the Environment Research CenterSANDRA HASLAM; Fiscal Year: 2007..abstract_text> ..
- HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGESRobert Cox; Fiscal Year: 2007Voltage-gated K+ (Kv) currents in native vascular smooth muscle cells (VSMC) are inhibited by an increase in cytosolic free Ca2+, secondary to intracellular Ca 2+ release or extracellular Ca2+ influx...
- Impact of feeding on brain response to food stimuli in lean and obese subjectsMarie Pierre St Onge; Fiscal Year: 2007..Results of this study will help create the foundation for the study of integrative responses to foods at the whole brain level in humans and will set the stage for a series of innovative experimental paradigms. ..
- ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 2007..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
- Role of the Unfolded Protein Response in Cardiac ProtectionCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2009Long-term Objective: Our long-term objective is to elucidate biochemical reactions in heart muscle cells that protect them from damaging stresses, such as deprivation of oxygen and nutrients...
- Remodeling of the Transverse Tubular System and Ryanodine Receptor Clusters in DyFRANK BERND SACHSE; Fiscal Year: 2010..Furthermore, there is very little information on the restoration of these structures and functions by cardiac resynchronization therapy. Our studies are designed to gain insights into these processes. ..
- Cardiovascular Stiffening in Aged Patients with CHFDavid Kass; Fiscal Year: 2005..This could lead to new therapeutic approaches to this difficult clinical problem that affects a growing aged patient population. ..
- ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 1992..The long term goal of these studies is to elucidate the biological basis of hormone independence and provide a rationale for treatment of hormone independent human mammary cancer...
- STROMA AND MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 1993....