Genomes and Genes
Summary: Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.
Publications186 found, 100 shown here
- Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonistsJames B Morris
Cellular Biochemistry Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne 8009, Victoria, Australia
Endocrinology 146:4370-6. 2005..This response was enhanced by phenylephrine and inhibited by EGF. FOXO1 is expressed, regulated, and functionally active in cardiomyocytes and thus may contribute to apoptotic responses in heart...
- High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitusBrian G Drew
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Circulation 119:2103-11. 2009..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
- Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signalingAnindita Das
Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0281, USA
J Biol Chem 280:12944-55. 2005..The results may have possible therapeutic potential in preventing myocyte cell death following ischemia/reperfusion...
- Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacitiesKarine Vauchez
Inserm U974, Paris, France
Mol Ther 17:1948-58. 2009..Our results suggest that ALDH activity is a novel marker for a population of new human skeletal muscle progenitors presenting a potential for cell biology and cell therapy...
- Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolismR Han
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, 200031, China
Diabetologia 50:1960-8. 2007..However, it is unknown whether APOA-I directly protects against diabetes. The aim of this study was to characterise the functional role of APOA-I in glucose homeostasis...
- [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]J Neuhaus
Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
Urologe A 46:1193-7. 2007..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells.
- Nuclei of non-muscle cells bind centrosome proteins upon fusion with differentiating myoblastsXavier Fant
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 4:e8303. 2009..Concomitantly, proteins of the centrosome relocalize from the pericentriolar material to the outer surface of the nucleus. The mechanisms that govern this relocalization are largely unknown...
- Quantification of rapid Myosin regulatory light chain phosphorylation using high-throughput in-cell Western assays: comparison to Western immunoblotsHector N Aguilar
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 5:e9965. 2010....
- Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stressR Vinayaga Moorthi
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry-605 006, India
Clin Chim Acta 367:132-6. 2006..out to explore the effect of prolonged low grade oxidative stress and vitamin E treatment on cultured rat L6 muscle cells. METHODS: L6 myotubes were incubated with vitamin E for 18 h and treated with H2O2 generating system for 12 h...
- Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cellsJerome E Lee
Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
PLoS ONE 5:e11201. 2010..Moreover, just as transcription factor activity varies between different cell types, the factors influencing mRNA decay are also cell-type specific...
- Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsTim Ting Chiu
Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
Mol Biol Cell 21:3529-39. 2010..We propose that Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
- TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cellsChristian W Keller
Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
J Biol Chem 286:3970-80. 2011....
- Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cellsYi Sun
Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Proc Natl Acad Sci U S A 107:19909-14. 2010..Intriguingly, the AS160-targeted Rabs appear to differ, with Rab8A participating in GLUT4 exocytosis in muscle cells and Rab10 in adipocytes, and their activation by insulin is unknown...
- Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytesJeffrey G Jacot
Department of Bioengineering, University of California, San Diego, USA
Biophys J 95:3479-87. 2008..On very stiff substrates, this adaptation seems to involve RhoA kinase...
- Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: application to detection of translocated glucose transporter 4 on the plasma membraneShin Nishiumi
Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe, Hyogo 657 8501, Japan
Biosci Biotechnol Biochem 71:2343-6. 2007The aim of this study was to establish a rapid preparation of plasma membrane from adipocytes and muscle cells to detect translocated glucose transporter (GLUT) 4...
- Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength trainingFrode Norheim
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
Am J Physiol Endocrinol Metab 301:E1013-21. 2011..Our aim was to identify the most abundantly secreted proteins in cultures of human skeletal muscle cells and to monitor their expression in muscles of strength-training individuals...
- Leptin expression in human primary skeletal muscle cells is reduced during differentiationRigmor Solberg
Department of Pharmacology, School of Pharmacy, University of Oslo, Oslo, Norway
J Cell Biochem 96:89-96. 2005..However, the expression of the leptin receptor (OB-Rb) mRNA, was unchanged during differentiation of the muscle cells. Administration of recombinant leptin had no effect on leptin, myogenin, myoD, or GLUT4 mRNA expressions during ..
- Lectin-like oxidized LDL receptor-1 (LOX-1) acts as a receptor for remnant-like lipoprotein particles (RLPs) and mediates RLP-induced migration of vascular smooth muscle cellsYo Aramaki
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
Atherosclerosis 198:272-9. 2008..in atherogenesis especially by diabetic dyslipidemia; however, their receptor(s) and effects on vascular smooth muscle cells (VSMCs) remain unclear...
- Morphological effects of myasthenia gravis patient sera on human muscle cellsSteven Paul Luckman
Institute of Clinical Medicine, Section for Neurology, University of Bergen and Haukeland University Hospital, N5021 Bergen, Norway
Muscle Nerve 33:93-103. 2006..of different autoantibody composition and obtained at different stages of disease severity, on primary human muscle cells. Sera from MG patients induced changes in cell morphology from typical elongated cells to an irregular ..
- Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin-mediated myogenesisPatrycja Pawlikowska
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02-776 Warsaw, Poland
Cell Prolif 39:127-45. 2006Viability and myogenesis from C2C12 muscle cells and L6 rat myoblasts were dose-dependently stimulated by insulin...
- Utrophin is a calpain substrate in muscle cellsIsabelle Courdier-Fruh
Santhera Pharmaceuticals, Hammerstrasse 25, CH 4410 Liestal, Switzerland
Muscle Nerve 33:753-9. 2006..In this study, we investigated the susceptibility of utrophin to cleavage by calpain in vitro and in muscle cells. We found that utrophin is a direct in vitro substrate of purified calpain I and II...
- Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cellsRussell Hyde
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, UK
FASEB J 19:461-3. 2005..attenuate the basal and insulin-stimulated activity of the Na+-dependent System A amino acid transporter in rat muscle cells (L6 myotubes) by depletion of the plasma membrane abundance of SNAT2 (a System A isoform)...
- Glucosamine-induced insulin resistance in L6 muscle cellsC J Bailey
School of Life and Health Sciences, Aston University, Birmingham, UK
Diabetes Obes Metab 6:293-8. 2004..Glucosamine increases flux through the hexosamine pathway, causing insulin resistance and disturbances similar to diabetic glucose toxicity...
- Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cellsYoussef Hibaoui
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, Quai Ernest Ansermet, Geneva, Switzerland
J Pineal Res 47:238-52. 2009..In conclusion, our findings suggest that inhibition of the PTP essentially contributes to the protective effect of melatonin against oxidative stress in myotubes...
- Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cellsSandro M Hirabara
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Butanta, Sao Paulo, Brazil
J Cell Physiol 222:187-94. 2010..Primary cultures of rat skeletal muscle cells exhibited similar responses to saturated FFA as compared to C2C12 cells...
- Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cellsJung Ok Lee
Department of Anatomy, Korea University College of Medicine, Seoul, Korea
J Cell Physiol 226:974-81. 2011..Unlike Rab4ΔCT, wild-type Rab4 co-localized with PKC-zeta. Together, these results demonstrate that metformin induces Rab4 expression via AMPK-AS160-PKC-zeta and modulates insulin-mediated GLUT4 translocation...
- Expression of a Clostridium perfringens type IV pilin by Neisseria gonorrhoeae mediates adherence to muscle cellsKatherine Rodgers
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
Infect Immun 79:3096-105. 2011..These findings implicate C. perfringens TFP in the ability of C. perfringens to adhere to and move along muscle fibers in vivo, which may provide a therapeutic approach to limiting this rapidly spreading and highly lethal infection...
- Protection of dystrophic muscle cells with polyphenols from green tea correlates with improved glutathione balance and increased expression of 67LR, a receptor for (-)-epigallocatechin gallateOlivier M Dorchies
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
Biofactors 35:279-94. 2009..Altogether our results demonstrate that GTP and EGCg protect muscle cells by scavenging H(2)O(2) and by improving the glutathione balance...
- An enhancer required for transcription of the Col6a1 gene in muscle connective tissue is induced by signals released from muscle cellsPaola Braghetta
Department of Histology Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
Exp Cell Res 314:3508-18. 2008..In face of the large body of work highlighting the relevance for human diseases of the adhesion of muscle cells with their surrounding extracellular matrix, remarkably little is known on how myogenic cells control gene ..
- The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic proteinValeria Kowaljow
Laboratorio de Neurogenética, Instituto de Investigacion, Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
Neuromuscul Disord 17:611-23. 2007..Overexpression of DUX4 induces cell death, induces caspase 3/7 activity and alters emerin distribution at the nuclear envelope. We propose that DUX4-mediated cell death contributes to the pathogenic pathway in FSHD...
- Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cellsAnna Planavila
Unidad de Farmacologia, Departamento de Farmacologia y Quimica Terapeutica, Facultad de Farmacia, Universidad de Barcelona, Spain
Biochim Biophys Acta 1736:120-7. 2005....
- Subcellular localization of fukutin and fukutin-related protein in muscle cellsHiroshi Matsumoto
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
J Biochem 135:709-12. 2004..Our data suggest that fukutin and FKRP may be involved at different steps in O-mannosylglycan synthesis of alpha-dystroglycan, and FKRP is most likely involved in the initial step in this synthesis...
- UV-embossed microchannel in biocompatible polymeric film: application to control of cell shape and orientation of muscle cellsJin-Ye Shen
The Biological and Chemical Process Engineering Laboratory, School of Mechanical and Aerospace Engineering, 50 Nanyang Avenue, Singapore 639798
J Biomed Mater Res B Appl Biomater 77:423-30. 2006..The effect of the micropatterns on A7r5 smooth muscle cells and C2C12 skeletal muscle cells was investigated...
- Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cellsVigdis Aas
Faculty of Health Sciences, Oslo University College, Oslo, Norway
J Lipid Res 47:366-74. 2006..the chronic effects of eicosapentaenoic acid (EPA) on fatty acid and glucose metabolism in human skeletal muscle cells. Uptake of [14C]oleate was increased >2-fold after preincubation of myotubes with 0...
- Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMPVarinder K Randhawa
Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Mol Biol Cell 15:5565-73. 2004Insulin and hypertonicity each increase the content of GLUT4 glucose transporters at the surface of muscle cells. Insulin enhances GLUT4 exocytosis without diminishing its endocytosis...
- Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiencyTimothy R Koves
Department of Medicine, and Sarah W Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina 27710, USA
J Biol Chem 280:33588-98. 2005..We proposed that PGC1alpha enables muscle mitochondria to better cope with a high lipid load, possibly reflecting a fundamental metabolic benefit of exercise training...
- Transfer of the full-length dystrophin-coding sequence into muscle cells by a dual high-capacity hybrid viral vector with site-specific integration abilityManuel A F V Gonçalves
Gene Therapy Section, Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
J Virol 79:3146-62. 2005..Dual hcAd/AAV hybrid vectors may thus be particularly useful to develop safe treatment modalities for diseases such as DMD that rely on efficient transfer and stable expression of large genes...
- Swelling-activated chloride channels in cardiac physiology and pathophysiologyClive M Baumgarten
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0551, USA. clive.baumgarten.vcu.edu
Prog Biophys Mol Biol 82:25-42. 2003..I(Cl,swell) plays a role in arrhythmogenesis, myocardial injury, preconditioning, and apoptosis of myocytes. As a result, I(Cl,swell) potentially is a novel therapeutic target...
- Restoration of dystrophin expression in mdx muscle cells by chimeraplast-mediated exon skippingCarmen Bertoni
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
Hum Mol Genet 12:1087-99. 2003..Such mutations generally lead to a complete absence of dystrophin protein in the muscle cells of affected individuals...
- Neuregulin signaling on glucose transport in muscle cellsCarles Canto
Departament de Bioquímica i Biologia Molecular and Parc Científic de Barcelona, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
J Biol Chem 279:12260-8. 2004..induces glucose transport through translocation of glucose transporters, in an additive manner to insulin, in muscle cells. In this study, we examined the signaling pathway required for a recombinant active neuregulin-1 isoform (..
- Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cellsHiroki Sugita
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Shriners Hospital for Children, Harvard Medical School, Boston, Massachusetts 02129, USA
J Biol Chem 280:14203-11. 2005..insulin receptor substrate (IRS)-1 protein expression without altering the mRNA level in cultured skeletal muscle cells. NO donor increased IRS-1 ubiquitination, and proteasome inhibitors blocked NO donor-induced reduction in IRS-1 ..
- How do mutations in lamins A and C cause disease?Howard J Worman
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 113:349-51. 2004....
- A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cellsGrazia Camarda
Depatment of Environment and Primary Prevention, Higher Institute of Health, 00161 Roma, Italy
J Cell Biol 167:417-23. 2004..Here, we show that terminal proliferation arrest is maintained in skeletal muscle cells by a pRb-independent mechanism...
- Intracellular generation of reactive oxygen species by contracting skeletal muscle cellsFrancis McArdle
Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Free Radic Biol Med 39:651-7. 2005The aim of this work was to examine the intracellular generation of reactive oxygen species in skeletal muscle cells at rest and during and following a period of contractile activity...
- Differentiation-induced radioresistance in muscle cellsLucia Latella
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
Mol Cell Biol 24:6350-61. 2004....
- Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complexTakeshi Hashimoto
Exercise Physiology Laboratory, Dept of Integrative Biology, 5101 Valley Life Sciences Bldg, Univ of California, Berkeley, CA 94720 3140, USA
Am J Physiol Endocrinol Metab 290:E1237-44. 2006....
- Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cellsTodd M Greco
Stokes Research Institute and Departments of Pediatrics and Pharmacology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:7420-5. 2006..capturing and site-specific adduct mapping to identify the targets of S-nitrosylation in human aortic smooth muscle cells upon exposure to S-nitrosocysteine and propylamine propylamine NONOate...
- MyoD undergoes a distinct G2/M-specific regulation in muscle cellsSabrina Batonnet-Pichon
Laboratoire de Génomique Fonctionnelle et Myogenèse, UMR 866 Différenciation, Cellulaire et Croissance, INRA UM II, Campus INRA ENSA, 2 Place Pierre Viala, 34060, Montpellier, Cedex 1, France
Exp Cell Res 312:3999-4010. 2006....
- Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractilityAdebowale Adebiyi
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38139, USA
Circ Res 106:1603-12. 2010....
- Immortalized skin fibroblasts expressing conditional MyoD as a renewable and reliable source of converted human muscle cells to assess therapeutic strategies for muscular dystrophies: validation of an exon-skipping approach to restore dystrophin in DuchenSoraya Chaouch
Universite Pierre et Marie Curie Paris 06, UMRS 974, Paris F 75013, France
Hum Gene Ther 20:784-90. 2009..Cellular models seem straightforward to set up; however, the proliferative capacity of muscle cells isolated from dystrophic patients is limited, and in addition it is difficult to envisage the use of large ..
- Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cellsHarold Couchoux
University Lyon 1, CNRS, Laboratory of Integrative, Cellular and Molecular Physiology, Villeurbanne, F 69622, France
J Physiol 580:745-54. 2007..results suggest that Cav-3 is involved in L-type Ca(2+) channel membrane function and localization in skeletal muscle cells and that an alteration of L-type Ca(2+) channels could be involved in the physiopathological mechanisms of ..
- Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cellsSung Soo Chung
Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
Mol Cell Biol 29:20-30. 2009..Here, we show that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling...
- Oestradiol and SERM treatments influence oestrogen receptor coregulator gene expression in human skeletal muscle cellsC M Dieli-Conwright
Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, Los Angeles, CA, USA
Acta Physiol (Oxf) 197:187-96. 2009..We investigated the influence of oestradiol and selective ER modulators [tamoxifen (TAM), raloxifene (RAL)] on ER coregulator mRNA expression in hSkM...
- Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocationShuhei Ishikura
Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
Am J Physiol Cell Physiol 295:C1016-25. 2008..Moreover, there is controversy as to the AS160/TBC1D1 target Rabs in fat and muscle cells, and Rab effectors are unknown...
- Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidantsLodovica Vergani
c o Venetian Institute of Molecular Medicine, Via Orus, 2 35129 Padova, Italy E mail
Brain 130:2715-24. 2007....
- Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cellsChandrasagar B Dugani
Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
Eur J Cell Biol 87:337-51. 2008..We propose that insulin causes selective, dynamic relocalization of perinuclear GLUT4myc and VAMP2 and perinuclear GLUT4myc redistribution is a direct target of insulin-derived signals...
- The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is depeLeonardo R Silveira
Institute of Biomedical Sciences, Department of Physiology and Biophysics, University of Sao Paulo, Sao Paulo, SP, Brazil
Biochim Biophys Acta 1763:969-76. 2006..Rat skeletal muscle cells were subjected to acute or repeated electrostimulation in the presence and absence of antioxidants...
- Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone conditionZ F Zhang
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China
Phytomedicine 17:14-8. 2010..Furthermore, we also demonstrated these EGCG effects essentially depended on the AMPK and Akt activation. Together, our data suggested that EGCG inhibited dexamethasone-induced insulin resistance through AMPK and PI3K/Akt pathway...
- Genetic complementation of human muscle cells via directed stem cell fusionManuel A F V Gonçalves
Virus and Stem Cell Biology Laboratory, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Mol Ther 16:741-8. 2008..whether human mesenchymal stem cells (hMSCs) can serve as donors of recombinant DMD genes for recipient human muscle cells. Here, we show that forced MyoD expression in hMSCs greatly increases their tendency to participate in human ..
- A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1Andrew K Snabaitis
Cardiovascular Division, King s College London, London SE1 7EH, UK
J Biol Chem 281:20252-62. 2006....
- Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytesDyke P McEwen
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 282:29612-20. 2007..current in atrial myocytes, and regulating the resting membrane potential and excitability of smooth muscle cells. Defects in the expression of Kv1...
- Identification of Rho GTPases implicated in terminal differentiation of muscle cells in ascidiaMarjorie Coisy-Quivy
CRBM, CNRS-FRE2593, IFR122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
Biol Cell 98:577-88. 2006..the role of Rho GTPases on myofibrillogenesis, we show that transcripts for all Rho GTPases are detected in muscle cells of the embryo...
- Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humansCostas A Anastasiou
Department of Dietetics and Nutrition, Laboratory of Nutrition and Clinical Dietetics, Harokopio University, 17671 Athens, Greece
Metabolism 58:1636-42. 2009..The total flux of fatty acids toward esterification may be a much more important factor in the pathophysiology of diabetes...
- Bone marrow stromal cells generate muscle cells and repair muscle degenerationMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
Science 309:314-7. 2005..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
- Possible link of different slow calcium signals generated by membrane potential and hormones to differential gene expression in cultured muscle cellsEnrique Jaimovich
Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Biol Res 37:625-33. 2004..We studied the effect of IGF-I, insulin and testosterone on intracellular Ca2+ in cultured muscle cells. Insulin produced a fast (< 1 s) and transient [Ca2+] increase lasting less than 10 s...
- Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitroSteve O Winitsky
Molecular Physiology Section, Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
PLoS Biol 3:e87. 2005..By 6 d they begin to differentiate without fusing to recipient cardiac cells. Three months later, the tagged cells are visible as striated heart muscle restricted to the region of the cardiac infarct...
- The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2Masanori Nojima
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA
J Mol Biol 382:275-87. 2008..results indicate that recruitment of P-TEFb is a critical step for stimulation of MEF2-dependent transcription, therefore providing a fundamentally important regulatory mechanism underlying the transcriptional program in muscle cells.
- The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha- and LPS-induced NF-kappaB-dependent transcription and TNF-alpha-induced IL-6 secretion in ventricular myocytesRajanya D Shah
The Rees-Stealy Research Foundation Laboratory, San Diego, USA
Cell Physiol Biochem 15:41-50. 2005..5-fold. Rosiglitazone had no significant effects on basal levels of NF-kappaB-dependent transcription and IL-6 secretion. Thus, cardioprotective effects of rosiglitazone may be partly mediated by NF-kappaB...
- Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffoldsMilica Radisic
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25-342, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 101:18129-34. 2004..Development of conductive and contractile properties of cardiac constructs was concurrent, with strong dependence on the initiation and duration of electrical stimulation...
- Homologous muscle acellular matrix seeded with autologous myoblasts as a tissue-engineering approach to abdominal wall-defect repairMaria Teresa Conconi
Section of Anatomy, Department of Human Anatomy and Physiology, University of Padova, Via Gabelli 65, I-35121 Padova, Italy
Biomaterials 26:2567-74. 2005....
- Antiretroviral protease inhibitors prevent l6 muscle cell fusion by reducing calpain activitySusan P Colby-Germinario
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, , , Canada H3T 1E2
AIDS Res Hum Retroviruses 20:1057-62. 2004..We conclude that RTV and IDV reduced myotube formation by reducing calpain activity. Our data suggest that protease inhibitors included in HAART might be directly involved in muscle wasting by reducing muscle remodeling...
- Cardiomyocyte dysfunction in insulin-resistant rats: a female advantageM L Schwanke
College of Arts and Sciences, University of Maine at Farmington, Farmington, ME, USA
Diabetologia 49:1097-105. 2006..Females show delayed onset and milder abnormalities in metabolic status and cardiomyocyte function, but with a much tighter temporal coupling of these dysfunctions...
- Calcium inhibits muscle FBPase and affects its intracellular localization in cardiomyocytesA Gizak
Department of Animal Physiology, Institute of Zoology, Wroclaw University, Cybulskiego 30, 50 205 Wroclaw, Poland
FEBS Lett 576:445-8. 2004..Additionally, Ca2+ appeared to be a strong inhibitor of muscle FBPase...
- Effects of burn serum on myocardial inflammation and functionJureta W Horton
Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390 9160, USA
Shock 22:438-45. 2004..Our finding that experimental approaches neutralizing circulating LPS provided cardioprotection suggested that bacterial endotoxin or LPS-like molecules contribute, in part, to burn-related myocardial contractile dysfunction...
- Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiationDavid Kuninger
Molecular Medicine Division, HRC 3, Department of Medicine, Oregon Health and Sciences University, Portland, OR 97239-3098, USA
Genomics 84:876-89. 2004..In cultured muscle cells, IGF action is critical both for maintaining viability during the transition from proliferating to ..
- Adrenergic and cholinergic activation of calcium signals in cultured postnatal skeletal myocytes of the ratK V Sobol
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223 Russia
Dokl Biol Sci 406:27-31. 2006
- NOV/CCN3 impairs muscle cell commitment and differentiationFrederico Calhabeu
Unité INSERM 515, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75371 Paris, France Pierre and Marie Curie University, Paris
Exp Cell Res 312:1876-89. 2006..Inhibition of differentiation by NOV was also observed with human primary muscle cells. Further examination of C2-NOV cells revealed a strong downregulation of the myogenic determination genes MyoD ..
- Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscleMelissa A Senetar
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
Cell Motil Cytoskeleton 64:157-73. 2007....
- Distinct signaling functions for Shc isoforms in the heartMaria Obreztchikova
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 281:20197-204. 2006....
- Inhibition of mechanosensitive cation channels inhibits myogenic differentiation by suppressing the expression of myogenic regulatory factors and caspase-3 activityNia Wedhas
Molecular Genetics Division, Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, California 92354, USA
FASEB J 19:1986-97. 2005..Our data suggest that inhibition of MSC suppresses myogenic differentiation by inhibiting the caspase-3 activity and the expression of myogenic regulatory factors...
- The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injuryTibor Kempf
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
Circ Res 98:351-60. 2006..In conclusion, our study identifies induction of GDF-15 in the heart as a novel defense mechanism that protects from I/R injury...
- Cardiac conduction through engineered tissueYeong-Hoon Choi
Department of Cardiac Surgery, Children's Hospital Boston, Boston, MA 02115, USA
Am J Pathol 169:72-85. 2006..Our experiments provide a proof-of-principle that engineered tissue constructs can function as an electrical conduit and, ultimately, may offer a substitute treatment to conventional pacing therapy...
- Emerin-lacking mice show minimal motor and cardiac dysfunctions with nuclear-associated vacuolesRitsuko Ozawa
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Am J Pathol 168:907-17. 2006..Our results suggest that emerin deficiency causes minimal motor and cardiac dysfunctions in mice with a structural fragility of myonuclei...
- Angiotensin II and stretch activate NADPH oxidase to destabilize cardiac Kv4.3 channel mRNAChaoming Zhou
Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Circ Res 98:1040-7. 2006..3 channel mRNA by activating NADPH oxidase. These results link long-term control of cardiac K+ channel gene expression to a physiological reactive oxygen species signaling pathway...
- Myocardin induces cardiomyocyte hypertrophyWeibing Xing
Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7126, USA
Circ Res 98:1089-97. 2006..These findings identify myocardin as a nuclear effector of hypertrophic signaling pathways that couples stress signals to a transcriptional program for postnatal cardiac growth and remodeling...
- Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeresSergey V Plotnikov
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3301, USA
Biophys J 90:693-703. 2006..This study should guide the interpretation of SHG contrast in images of cardiac and skeletal muscle tissue for a variety of biomedical applications...
- Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile responseMargaret V Westfall
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 280:41324-31. 2005....
- Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophyJi Luo
Division of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, 10th Floor, Boston, MA 02115, USA
Mol Cell Biol 25:9491-502. 2005..Our results therefore provide strong genetic evidence that class I(A) PI3Ks are critical regulators for the developmental growth and physiological hypertrophy of the heart...
- The effects of Ankrd2 alteration indicate its involvement in cell cycle regulation during muscle differentiationCamilla Bean
Department of Biology and CRIBI Biotechnology Centre, University of Padova, Via Ugo Bassi 58 B, 35131 Padova, Italy
Biochim Biophys Acta 1783:1023-35. 2008..for the basal functioning of skeletal muscle, its influence on the gene expression program of skeletal muscle cells was highlighted...
- Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2DMin Du
Department of Biology, York University, 4700 Keele Street, Toronto M3J 1P3, Ontario, Canada
Mol Cell Biol 28:2952-70. 2008..Collectively, these data identify MEF2D as a primary target of PKA signaling in myoblasts that leads to inhibition of the skeletal muscle differentiation program...
- The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its functionPiyali Dhar-Chowdhury
Department of Pediatrics, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 280:38464-70. 2005..Our data are consistent with the concept that the activity of these enzymes (possibly by ATP formation in the immediate intracellular microenvironment of this macromolecular K(ATP) channel complex) causes channel closure...
- Intracellular and extracellular concentrations of Na+ modulate Mg2+ transport in rat ventricular myocytesMichiko Tashiro
Department of Physiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
Biophys J 89:3235-47. 2005..These results contribute to a quantitative characterization of the Na+-Mg2+ exchange in cardiac myocytes...
- Differential myocardial infarct repair with muscle stem cells compared to myoblastsHideki Oshima
Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213-2582, USA
Mol Ther 12:1130-41. 2005..These findings indicate that MDSCs constitute an alternative to other myogenic cells for use in cardiac repair applications...
- Hypokalemia potentiates ouabain's effect on calcium cycling and cardiac growthJ I Shapiro
The Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio 43614-5089, United States
Cell Mol Biol (Noisy-le-grand) 52:87-91. 2006..These data suggest that hypokalemia may produce phenotypic alterations consistent with cardiac hypertrophy as well as potentiate the cardiovascular effects of cardiotonic steroids...
- Method of cell transplantation promoting the organization of intraarterial thrombusKoji Hirano
Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
Circulation 112:I111-6. 2005..Especially, myoblasts enhanced differentiation of fibroblasts into myofibroblasts, contributing to rapid thrombus organization. Cell transplantation into unorganized spaces seems applicable to endovascular treatment of aneurysms...
- Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activityJyothish B Pillai
Department of Cardiothoracic Surgery, University of Chicago, IL 60637, USA
J Biol Chem 280:43121-30. 2005..These data demonstrate that, in stressed cardiac myocytes, depletion of cellular NAD levels forms a link between PARP activation and reduced Sir2alpha deacetylase activity, contributing to myocyte cell death during heart failure...
- [Human fetal ventricular cardiomyocytes in vitro: proliferation and differentiation]I L Erokhina
Tsitologiia 47:200-6. 2005..8 +/- 0.5% of muscle and 25.2 +/- 11.7% of non-muscle cells are labeled, in 14 day-old culture--2.5 +/- 0.5 and 8.1 +/- 1.7% of cells are labeled, respectively...
- Nuclear factor kappaB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cellsM Valeria Catani
Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
Free Radic Biol Med 37:1024-36. 2004Skeletal muscle cells are continuously exposed to oxidative stress...
- Regulation of cardiac beta 1-adrenergic receptor transcription during the developmental transitionRajan Wadhawan
Women and Infants Hospital of Rhode Island, Brown University School of Medicine, Providence 02905 2499, USA
Am J Physiol Heart Circ Physiol 284:H2146-52. 2003..These results suggest that the regulation of cardiac beta(1)AR transcription and the expression of c-myc are tightly integrated...
- Carbon disulfide cytotoxicity on cultured cardiac myocyte cell of ratsXiaodong Tan
Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Donghu Road 115, Wuhan, 430071, People s Republic of China
Ecotoxicol Environ Saf 55:168-72. 2003..The biochemical mechanism may be a reduction of the availability of energy of the cardiac cytocyte in the form of ATP, resulting in a decrease of contractility by lacking of energy...
- Effects of platelet-derived growth factor-AA and -BB on embryonic cardiac developmentRobert L Price
Department of Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina, USA
Anat Rec A Discov Mol Cell Evol Biol 272:424-33. 2003..These studies indicate that increased exposure of embryonic hearts to PDGF-AA or -BB increases the rate of myocardial development...
Research Grants151 found, 100 shown here
- Dynamics of Oxygen Uptake in Contracting Single MyocytesCASEY KINDIG; Fiscal Year: 2003..abstract_text> ..
- Bi-directional Calcium Signaling in Striated MusclesJianjie Ma; Fiscal Year: 2007In striated muscle cells, the transverse tubular (TT) invagination of plasma membrane contacts the terminal cisternae of sarcoplasmic reticulum (S...
- RYANODINE RECEPTOR OF E/C COUPLING IN STRIATED MUSCLESJianjie Ma; Fiscal Year: 2001The ryanodine receptor (RyR) is an essential component of excitation- contraction (E-C) coupling in striated muscle cells, whereby a depolarization across the transverse tubule (TT) membrane leads to rapid release of Ca from the ..
- Store-Operated Calcium Entry and ApoptosisJianjie Ma; Fiscal Year: 2007..Knowledge on the molecular interactions between apoptosis mediators and cytosolic factors that control SOCE will enable us to establish therapeutic agents that target Ca signaling in cancer and degenerative diseases. ..
- High fat feeding and intramyocellular lipid abnormalityZengKui Guo; Fiscal Year: 2005..Thus, the proposed research will improve the understanding of the mechanism of insulin resistance and imcTG abnormalities in the obese rat that will benefit investigation of human obesity. ..
- Bidirectional Ca Signaling Between Cell Surface and InraJianjie Ma; Fiscal Year: 2005..project is to understand the cellular and molecular function of these novel JP genes in the Ca signaling of muscle cells, specifically to test the hypothesis that JP plays important roles in the ultrastructural arrangement of the ..
- RECONSTITUTION OF CFTR CHLORIDE CHANNELJianjie Ma; Fiscal Year: 2004..Fulfillment of the experiments proposed in this project should provide further insights into the function and regulation of the CFTR Cl- channel, as well as the potential therapeutic interventiosn in cystic fibrosis. ..
- Role of MG29 in E-C Coupling of Striated MusclesJianjie Ma; Fiscal Year: 2006..long term goal of this project is to understand the cellular and molecular function of MG29 in E-C coupling of muscle cells, specifically to test the hypothesis that MG29 is a key protein involved in the biogenesis of the T-tubule ..
- Calcium Signaling and Cytochrome C Release in ApoptosisJianjie Ma; Fiscal Year: 2005..Our long term goal of this project is to understand the cellular and molecular mechanism of Ca signaling in apoptosis, and to provide alternative interventions in the therapy of prostate cancer. ..
- Ca Sparks in Muscle Aging and DystrophyJianjie Ma; Fiscal Year: 2007Ca sparks are the elementary units of Ca-induced Ca release (CICR) in striated muscle cells revealed as localized Ca release events from sarcoplasmic reticulum (SR) by confocal microscopy...
- Store-Operated Calcium Entry and ApoptosisJianjie Ma; Fiscal Year: 2010..Knowledge on the molecular interactions between apoptosis mediators and cytosolic factors that control SOCE will enable us to establish therapeutic agents that target Ca signaling in cancer and degenerative diseases. ..
- TRIC, a Novel Modulator of Intracellular Ca HomeostasisJianjie Ma; Fiscal Year: 2010..For efficient operation of excitation-contraction coupling in muscle cells, or excitation-secretion coupling in non-muscle cells, counter ion movement across the SR or ER membrane must ..
- Ca Sparks in Muscle Aging and DystrophyJianjie Ma; Fiscal Year: 2010Ca sparks are the elementary units of Ca-induced Ca release (CICR) in striated muscle cells revealed as localized Ca release events from sarcoplasmic reticulum (SR) by confocal microscopy...
- Bi-directional Calcium Signaling in Striated MusclesJianjie Ma; Fiscal Year: 2010In striated muscle cells, the transverse tubular (TT) invagination of plasma membrane contacts the terminal cisternae of sarcoplasmic reticulum (S...
- RECONSTITUTION OF CFTR CHLORIDE CHANNELJianjie Ma; Fiscal Year: 2000..In addition, the studies may lead to engineering of CFTR channels with higher activity, which will be useful for high efficiency gene therapy for CF. ..
- Actions of Ethanol on Ligand-Gated Ion ChannelsGustav Akk; Fiscal Year: 2006..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
- SPECT MAMMOGRAPHY USING ROTATING SLANT HOLE COLLIMATORSTEPHEN KNISLEY; Fiscal Year: 2001..It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer. ..
- SUMMER RESEARCH PROGRAM FOR MINORITY MEDICAL STUDENTSDonald Menick; Fiscal Year: 2007....
- The ER Stress Response and ATF6 Activation in the HeartCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
- Mechanisms regulating SR Ca2+ ATPase in the AtriaMuthu Periasamy; Fiscal Year: 2010..These studies will employ genetically engineered mouse models to understand if loss of Sarcolipin protein has an effect on cardiac function. ..
- Role of the Unfolded Protein Response in Cardiac ProtectionChristopher C Glembotski; Fiscal Year: 2010Long-term Objective: Our long-term objective is to elucidate biochemical reactions in heart muscle cells that protect them from damaging stresses, such as deprivation of oxygen and nutrients...
- Sleep deprivation and energy balanceMarie Pierre St Onge; Fiscal Year: 2010..This study will examine how food intake and energy expenditure can be modified by sleep duration as a means of understanding a potential causal pathway. ..
- Cardiovascular Stiffening in Aged Patients with CHFDavid Kass; Fiscal Year: 2005..This could lead to new therapeutic approaches to this difficult clinical problem that affects a growing aged patient population. ..
- ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 2007..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
- HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGESRobert Cox; Fiscal Year: 2007Voltage-gated K+ (Kv) currents in native vascular smooth muscle cells (VSMC) are inhibited by an increase in cytosolic free Ca2+, secondary to intracellular Ca 2+ release or extracellular Ca2+ influx...
- Role of the Unfolded Protein Response in Cardiac ProtectionCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2009Long-term Objective: Our long-term objective is to elucidate biochemical reactions in heart muscle cells that protect them from damaging stresses, such as deprivation of oxygen and nutrients...
- Breast Cancer and the Environment Research CenterSANDRA HASLAM; Fiscal Year: 2007..abstract_text> ..
- Trypanosoma cruzi and AIDS: Role of the AdipocyteHerbert Tanowitz; Fiscal Year: 2007....
- Impact of feeding on brain response to food stimuli in lean and obese subjectsMarie Pierre St Onge; Fiscal Year: 2007..Results of this study will help create the foundation for the study of integrative responses to foods at the whole brain level in humans and will set the stage for a series of innovative experimental paradigms. ..
- Novel epoxide hydrolase inhibitor for stroke preventionJOHN IMIG; Fiscal Year: 2005..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
- STROMA AND MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 1993....
- ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 1992..The long term goal of these studies is to elucidate the biological basis of hormone independence and provide a rationale for treatment of hormone independent human mammary cancer...