peritoneal macrophages

Summary

Summary: Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.

Top Publications

  1. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
  2. ncbi A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
    H Suzuki
    Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
    Nature 386:292-6. 1997
  3. ncbi Characterization of latent TGF-beta activation by murine peritoneal macrophages
    I Nunes
    Department of Cell Biology, New York University Medical Center, New York 10016, USA
    J Immunol 155:1450-9. 1995
  4. ncbi Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    K Hoshino
    Department of Biochemistry, Hyogo College of Medicine, Japan
    J Immunol 162:3749-52. 1999
  5. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
  6. pmc Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
    Tracie DeVries-Seimon
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 171:61-73. 2005
  7. pmc Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1
    M Fukuzumi
    Department of Microbiology, Ehime University School of Medicine, Japan
    Infect Immun 64:108-12. 1996
  8. ncbi Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages
    Sanghyun Lee
    Department of Applied Plant Science, Chung Ang University, Anseong 456 756, Korea
    Phytother Res 22:1552-6. 2008
  9. ncbi Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetate
    Stefan Jung
    Klinische Forschungsgruppe für Multiple Sklerose an der Neurologischen Klinik, Julius Maximilians Universitat Wurzburg, Germany
    J Neuroimmunol 148:63-73. 2004
  10. ncbi Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages
    Reiko Okutsu
    Free Radical Project, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Atherosclerosis 204:405-11. 2009

Research Grants

Detail Information

Publications320 found, 100 shown here

  1. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
  2. ncbi A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
    H Suzuki
    Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
    Nature 386:292-6. 1997
    ..In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens...
  3. ncbi Characterization of latent TGF-beta activation by murine peritoneal macrophages
    I Nunes
    Department of Cell Biology, New York University Medical Center, New York 10016, USA
    J Immunol 155:1450-9. 1995
    ..by macrophages was characterized using serum-free cultures of resident and thioglycollate-elicited murine peritoneal macrophages that were either unstimulated or LPS-stimulated in vitro...
  4. ncbi Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    K Hoshino
    Department of Biochemistry, Hyogo College of Medicine, Japan
    J Immunol 162:3749-52. 1999
    ..Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ mice activated NF-kappaB. Taken together, the present study demonstrates that TLR4 is the gene product that regulates LPS response...
  5. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  6. pmc Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
    Tracie DeVries-Seimon
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 171:61-73. 2005
    ..These findings have important implications for understanding how the UPR, MAPKs, and the SRA might conspire to cause macrophage death, lesional necrosis, and plaque destabilization in advanced atherosclerotic lesions...
  7. pmc Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1
    M Fukuzumi
    Department of Microbiology, Ehime University School of Medicine, Japan
    Infect Immun 64:108-12. 1996
    ..These results suggest that macrophage responses to LPS are supported by a rapid and sustained glucose influx via GLUT1 and that this is a participating factor in the development of systemic hypoglycemia when endotoxemia is prolonged...
  8. ncbi Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages
    Sanghyun Lee
    Department of Applied Plant Science, Chung Ang University, Anseong 456 756, Korea
    Phytother Res 22:1552-6. 2008
    ..of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS, 1 microg/mL)-stimulated rat peritoneal macrophages were examined...
  9. ncbi Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetate
    Stefan Jung
    Klinische Forschungsgruppe für Multiple Sklerose an der Neurologischen Klinik, Julius Maximilians Universitat Wurzburg, Germany
    J Neuroimmunol 148:63-73. 2004
    ..Using freshly isolated resident peritoneal macrophages from naive Lewis rats, it is shown that GLAT profoundly modulates cytokine secretion of the cells...
  10. ncbi Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages
    Reiko Okutsu
    Free Radical Project, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Atherosclerosis 204:405-11. 2009
    ..Thus, we investigated the effect of cilostazol on LDL uptake in mouse peritoneal macrophages (MPM)...
  11. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
    ....
  12. pmc Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    Kenneth A Howard
    Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
    Mol Ther 17:162-8. 2009
    ..anti-TNF-alpha Dicer-substrate siRNA (DsiRNA) mediated TNF-alpha knockdown (approximately 66%) in primary peritoneal macrophages in vitro...
  13. ncbi Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36
    Yasutaka Ikeda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Immunol 178:4854-64. 2007
    ..In this study, we examined the effects of UA on the production of several cytokines in resident murine peritoneal macrophages (pMphi)...
  14. pmc A critical role of activin A in maturation of mouse peritoneal macrophages in vitro and in vivo
    Yinan Wang
    Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China
    Cell Mol Immunol 6:387-92. 2009
    ..that activin A not only increased NO and IL-1beta release, but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo, whereas it did not influence MHC I and MHC II expression...
  15. pmc CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophages
    Gerritje J W van der Windt
    Center of Infection and Immunity Amsterdam, Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 78:115-24. 2010
    ..coli-induced abdominal sepsis and to assess the function of CD44 in the activation of primary peritoneal macrophages by E...
  16. ncbi Comparison of the response of primary murine peritoneal macrophages and the U937 human histiocytic cell line to challenge with in vitro generated clinically relevant UHMWPE particles
    J B Matthews
    Immunology Research Laboratory, Division of Microbiology, The University of Leeds, UK
    Biomed Mater Eng 10:229-40. 2000
    ..Moreover, primary murine macrophages have been demonstrated to be a suitable model for studying cell-particle interactions in vitro...
  17. ncbi Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosis
    Ali Akoum
    Département d obstétrique gynécologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 77:989-94. 2002
    To assess spontaneous and stimulated secretion of monocyte chemotactic protein-1 (MCP-1) and macrophage migration inhibitory factor (MIF) by peritoneal macrophages in women with and without endometriosis.
  18. ncbi The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages
    Viswanathan Saraswathi
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Lipid Res 47:1406-15. 2006
    ..Incubation of mouse peritoneal macrophages with 100 microg/ml VLDL for 6 h led to 2.8- and 3...
  19. ncbi Protective effect of polysaccharide fractions from Radix A. sinensis against tert-butylhydroperoxide induced oxidative injury in murine peritoneal macrophages
    Xingbin Yang
    Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi an 710062, China
    J Biochem Mol Biol 40:928-35. 2007
    ..sinensis and their antioxidant activities were evaluated in isolated mouse peritoneal macrophages by pretreatment with APFs before exposure to 0.2 mM tertbutylhydroperoxide (t-BHP)...
  20. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  21. ncbi Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro
    Santanu Kar Mahapatra
    Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721 102, West Bengal, India
    Eur J Pharmacol 623:132-40. 2009
    ..aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine...
  22. ncbi High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
    A Veillette
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Biol Chem 273:22719-28. 1998
    ..Expression of SHPS-1 could also be documented in normal ex vivo peritoneal macrophages. Further studies showed that SHPS-1 was an efficient tyrosine phosphorylation substrate in macrophages...
  23. ncbi Effect of 6-gingerol on pro-inflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophages
    Sudipta Tripathi
    Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Surg Res 138:209-13. 2007
    ....
  24. ncbi Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancer
    Makoto Matsui
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 101:1670-7. 2010
    ..delivery system (DDS) using oligomannose-coated liposomes (OMLs), which are effectively taken up by mouse peritoneal macrophages to carry anticancer drugs to omental milky spots known as initial metastatic sites in the peritoneal ..
  25. ncbi Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    Osamu Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 169:10-4. 2002
    ..Taken together, TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides...
  26. ncbi Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
    M D Lehner
    Biochemical Pharmacology, University of Konstanz, Konstanz, Germany
    J Immunol 166:5161-7. 2001
    ....
  27. ncbi The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells
    Y Xia
    Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 162:2281-90. 1999
    ..The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans...
  28. ncbi Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathway
    K Stoffels
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Onderwijs en Navorsing, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:567-71. 2007
    ..We have previously shown that in murine peritoneal macrophages 1alpha-hydroxylase is highly regulated by immune signals such as IFNgamma and LPS...
  29. pmc Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events
    S Bhattacharyya
    Department of Microbiology, Bose Institute, Calcutta 700 054, India
    Infect Immun 69:1499-507. 2001
    ..donovani induces endogenous secretion of murine IL-10, which in turn facilitates the intracellular survival of the protozoan and orchestrates several immunomodulatory roles via selective impairment of PKC-mediated signal transduction...
  30. ncbi IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages
    P Puddu
    Laboratorie of Immunology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 159:3490-7. 1997
    We previously reported that resting mouse peritoneal macrophages (PM) constitutively express low levels of IFN-gamma, whose production is consistently enhanced by exogenous IFN-gamma...
  31. pmc Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability
    Miriam Rodriguez-Sosa
    Department of Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, D F Mexico 14080, Mexico
    Infect Immun 70:3656-64. 2002
    ..Here, we have used peritoneal macrophages (F4/80+) recruited at different times after challenge with Taenia crassiceps as APC and tested their ..
  32. ncbi Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
    S Akashi
    Department of Immunology, Saga Medical School, Nabeshima, Japan
    J Immunol 164:3471-5. 2000
    ..Thioglycolate-elicited peritoneal macrophages expressed TLR4-MD-2, which was rapidly down-regulated in the presence of LPS...
  33. pmc Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone
    L P Shornick
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 183:1427-36. 1996
    ..Endotoxin-stimulated peritoneal macrophages from IL-1beta-deficient mice showed normal synthesis and cellular release of IL-1alpha after treatment ..
  34. pmc Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
    Richard Malley
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1966-71. 2003
    ..We conclude that the interaction of pneumolysin with TLR4 is critically involved in the innate immune response to pneumococcus...
  35. ncbi Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein
    D Sun
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 271:24055-62. 1996
    ..By in situ hybridization we show that the L-12LO gene is expressed abundantly in a subset of peritoneal macrophages but not in elicited leukocytes, alveolar macrophages, or bone marrow-derived macrophages...
  36. ncbi Crotalus durissus terrificus snake venom regulates macrophage metabolism and function
    S C Sampaio
    Laboratory of Pathophysiology, Butantan Institute, , Brazil
    J Leukoc Biol 70:551-8. 2001
    ..This cell activation state does not include inflammatory properties of spreading and phagocytosis...
  37. ncbi Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2
    Shahid Noor
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 283:4744-55. 2008
    ..Listeria monocytogenes stimulates arachidonic acid release and eicosanoid production from resident mouse peritoneal macrophages through activation of group IVA cytosolic phospholipase A2 (cPLA2alpha). The ability of wild type L...
  38. ncbi Increased activation of nuclear factor-kappa B (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosis
    Jean Christophe Lousse
    Fonds de la Recherche Scientifique, FNRS, Belgium
    Fertil Steril 90:217-20. 2008
    Endometriosis is characterized by pelvic inflammation that shows an increased number of activated peritoneal macrophages and their secreted products such as cytokines, growth factors, and angiogenic factors...
  39. ncbi Regulation of LPS stimulated ROS production in peritoneal macrophages from alloxan-induced diabetic rats: involvement of high glucose and PPARgamma
    Luiz Fernando De Souza
    Departamento de Bioquimica, UFRGS, Porto Alegre, RS, Brazil
    Life Sci 81:153-9. 2007
    ..lipopolysaccharide (LPS) stimulated reactive oxygen species (ROS) and nitrite production were evaluated in peritoneal macrophages from alloxan-induced diabetic rats...
  40. ncbi Production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma in murine peritoneal macrophages on treatment with wheat germ agglutinin in vitro: involvement of tyrosine kinase pathways
    Ajit Sodhi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Glycoconj J 24:573-82. 2007
    ....
  41. ncbi Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in mice
    Ricardo Ambrósio Fock
    Experimental Haematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Brazil
    Cytokine 40:105-14. 2007
    ..These data lead us to infer that the nutritional state interferes with the activation of macrophages and with the capacity to mount an immune response...
  42. ncbi Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages
    T Ishii
    Department of Biochemistry, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 232:33-7. 1997
    ..The levels of glucose oxidase-induced A170 protein did not decrease after the addition of cycloheximide. These results suggest that low levels of H2O2 may stabilize the A170 protein, allowing it to accumulate within cells...
  43. ncbi Segregated coupling of phospholipases A2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages
    H Naraba
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Japan
    J Immunol 160:2974-82. 1998
    ..enzymes regulating the initial, intermediate, and terminal steps of PG biosynthesis to provide PGs in rat peritoneal macrophages stimulated with LPS and/or A23187...
  44. ncbi Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages
    Amy C Morrison
    Department of Veterinary Science and Graduate Program in Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 168:853-60. 2002
    ..In this study, we demonstrate that stimulation of murine peritoneal macrophages with MSP results in the RON-dependent up-regulation of arginase, an enzyme associated with alternative ..
  45. ncbi Gene transfer by DNA/mannosylated chitosan complexes into mouse peritoneal macrophages
    Mayu Hashimoto
    Department of Biosciences and Informatics, Keio University, 3 14 1, Hiyoshi, Yokohama 223 8522, Japan
    Biotechnol Lett 28:815-21. 2006
    ..The pDNA/man-chitosan complexes showed no significant cytotoxicity in mouse peritoneal macrophages, while pDNA/man-PEI complexes showed strong cytotoxicity...
  46. ncbi Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
    Cancer Lett 230:219-27. 2005
    ..the effects of soybean saponins on the production of proinflammatory mediators in LPS-stimulated peritoneal macrophages. Soybean saponins significantly inhibited the release of PGE(2), NO, TNFalpha and monocyte chemotactic ..
  47. ncbi A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages
    Hui Hsin Chang
    Department of Horticulture, National TaiwanUniversity, Taipei 10673, Taiwan, Republic of China
    J Agric Food Chem 57:6129-39. 2009
    ..Results obtained with peritoneal macrophages from TLR4-deficient C57BL/10ScN mice revealed that PCP-induced activation and PCP cell surface binding ..
  48. ncbi Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus
    Carol A Rouzer
    Department of Biochemistry, the Vanderbilt Institute of Chemical Biology, the Center in Molecular Toxicology, Nashville, TN 37232 0146, USA
    J Biol Chem 280:26690-700. 2005
    ..PG-G formation has not been demonstrated in intact cells treated with a physiological agonist. Resident peritoneal macrophages, which express COX-1, were pretreated with lipopolysaccharide to induce COX-2...
  49. pmc Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites
    R Frances
    Department of Immunology, Hospital General Universitario, Pintor Baeza s n, Alicante, Spain
    Gut 53:860-4. 2004
    ..vitro, and we hypothesised that the presence of bacterial DNA could activate the type I immune response in peritoneal macrophages from these patients, leading to greater cytokine synthesis (interleukin (IL)-2 and IL-12, tumour necrosis ..
  50. ncbi Peritoneal macrophages induce RANTES (regulated on activation, normal T cell expressed and secreted) chemokine gene transcription in endometrial stromal cells
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 89:1397-401. 2004
    ..from four patients were used to prepare stromal cell cultures, and pelvic fluid was collected to isolate peritoneal macrophages. A full length (-940 bp) human RANTES promoter construct provided an indicator of transcriptional ..
  51. ncbi Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
    Yongliang Zhang
    Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
    Nature 430:793-7. 2004
    ..Therefore, MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases...
  52. ncbi Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide
    Amy C Morrison
    Department of Veterinary Science, Graduate Program in Biochemistry, Microbiology, and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 172:1825-32. 2004
    ..Taken together, these results suggest that MSP may actively suppress cell-mediated immune responses through its ability to down-regulate IL-12 production and thus inhibit classical activation of macrophages...
  53. ncbi Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid
    Jean Christophe Lousse
    Department of Gynecology, Universite Catholique de Louvain, Brussels, Belgium
    Fertil Steril 91:1668-75. 2009
    To further investigate peritoneal iron disruption in endometriosis by studying iron storage in peritoneal macrophages of patients with endometriosis compared with controls.
  54. ncbi FcR gamma chain deletion results in pleiotrophic effector cell defects
    T Takai
    DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
    Cell 76:519-29. 1994
    ..These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses...
  55. ncbi 1'S-1'-Acetoxychavicol acetate as a new type inhibitor of interferon-beta production in lipopolysaccharide-activated mouse peritoneal macrophages
    Shin Ando
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem 13:3289-94. 2005
    ..show potent inhibitory effect on the production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. To clarify its mechanism of action, the effects of 1'S-1'-acetoxychavicol acetate on the expression of ..
  56. ncbi In vitro induction of nitric oxide by mouse peritoneal macrophages treated with human placental extract
    Piyali Datta Chakraborty
    Division of Structural Biology and Bioinformatics, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700032, India
    Int Immunopharmacol 6:100-7. 2006
    ..extract of human placenta used as wound healer, has been investigated in terms of induction of NO by mouse peritoneal macrophages as well as human monocyte derived macrophages...
  57. ncbi 3,5-Nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages
    Dejan D Doković
    Faculty of Chemistry, University of Belgrade, Serbia and Montenegro
    Chem Pharm Bull (Tokyo) 52:853-4. 2004
    ..7+/-0.8 microM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation...
  58. ncbi Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production
    Jun Akaogi
    University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
    J Leukoc Biol 76:227-36. 2004
    ..b>Peritoneal macrophages were isolated (biomagnetic beads) from BALB/c, DBA/1, or C57BL/6 mice treated with pristane (..
  59. ncbi Phenotypic and functional analysis of murine resident and induced peritoneal macrophages
    Lyubomyr R Turchyn
    Department of Comparative Medicine, Pfizer Global Research and Development, Ann Arbor, MI, USA
    Comp Med 57:574-80. 2007
    ..Although approximately 1 million peritoneal macrophages can be obtained from an untreated mouse, more than twice that number can be collected 48 to 72 h after ..
  60. ncbi Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:2525-33. 2005
    ..We further demonstrate that phosphorylation of Lin-11, Isl-1, Mec-3 (LIM) kinase and cofilin is promoted by treating macrophages with alpha2M*. Thus, alpha2M* regulates activation of the PAK-2-dependent motility mechanism in these cells...
  61. ncbi Inhibition of nitric oxide and tumor necrosis factor-alpha by moutan cortex in activated mouse peritoneal macrophages
    Hwan Suck Chung
    Purimed R and D Institute, Kyung Hee University, Dongdaemoon gu, Seoul, Korea
    Biol Pharm Bull 30:912-6. 2007
    ..production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-gamma-induced expression of inducible nitric oxide synthase (iNOS) and TNF-..
  62. ncbi Participation of macrophage membrane rafts in Trypanosoma cruzi invasion process
    E S Barrias
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, CCS, UFRJ, Ilha do Fundao, 21941 902 Rio de Janeiro, RJ, Brazil
    Biochem Biophys Res Commun 363:828-34. 2007
    ..cruzi parasitophorous vacuole. Taken together these data suggest that membrane rafts, including caveolae, are involved in the process of T. cruzi invasion of macrophages...
  63. ncbi Intraperitoneal immunization with oligomannose-coated liposome-entrapped soluble leishmanial antigen induces antigen-specific T-helper type immune response in BALB/c mice through uptake by peritoneal macrophages
    Y Shimizu
    Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
    Parasite Immunol 29:229-39. 2007
    ..OML were preferentially and rapidly incorporated into peritoneal macrophages, and the transplantation of macrophages containing SLA-OML into the peritoneal cavity also induced ..
  64. ncbi Trehalose inhibits inflammatory cytokine production by protecting IkappaB-alpha reduction in mouse peritoneal macrophages
    Kahoru Taya
    Division of Dental Pharmacology, Department of Oral Medical Science, Ohu University School of Dentistry, Koriyama, Fukushima 963 8611, Japan
    Arch Oral Biol 54:749-56. 2009
    The aim of this study was to examine whether trehalose, a disaccharide, could inhibit Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS)-enhanced production of inflammatory cytokines in mouse peritoneal macrophages.
  65. pmc Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro
    A Vazquez-Torres
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Exp Med 192:227-36. 2000
    ..These findings demonstrate that macrophages kill Salmonella in a dynamic process that changes over time and requires the generation of both reactive oxidative and nitrosative species...
  66. ncbi IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages
    Lei Liu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    J Interferon Cytokine Res 24:334-42. 2004
    ..stimulated cAMP accumulation and PKA activation in time-dependent and dose-dependent manners in murine peritoneal macrophages. Moreover, IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly ..
  67. ncbi Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages
    Palash Mandal
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 178:2542-8. 2007
    ..These findings demonstrate that LY2/LY3 targets a novel TLR4-linked signaling pathway that selectively couples to the stabilization of FPR1 mRNA...
  68. ncbi Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility
    Barbara H Osborn
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Fertil Steril 77:46-51. 2002
    Determine whether peritoneal macrophages from women with endometriosis-associated infertility express more inducible nitric oxide synthase (NOS2) and produce more NO than fertile controls.
  69. ncbi Effect of mineral trioxide aggregate on cytokine production by peritoneal macrophages
    T M B Rezende
    Departamento de Dentística Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Int Endod J 38:896-903. 2005
    ..To test the effect of two commercial brands of grey mineral trioxide aggregate (ProRoot and MTA-Angelus) on cytokine production by M1 and M2 inflammatory macrophages...
  70. ncbi Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
    J Immunol 165:5392-6. 2000
    ..aureus infection, with more enhanced susceptibility in MyD88-deficient mice. Peritoneal macrophages from MyD88-deficient mice did not produce any detectable levels of cytokines in response to S. aureus...
  71. ncbi IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages
    Patrizia Puddu
    Department of Cell Biology and Neurosciences, Viale Regina Elena 299, 00161 Rome, Italy
    J Leukoc Biol 78:686-95. 2005
    ..capable of activating certain macrophage functions, on interferon (IFN)-gamma expression in resting mouse peritoneal macrophages (PM). IL-2 addition to PM from different mouse strains up-modulated IFN-gamma mRNA and protein secretion...
  72. pmc The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations
    G Grigoriadis
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria, Australia
    EMBO J 15:7099-107. 1996
    ..Stimulated Rel-/- resident peritoneal macrophages produced higher than normal levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), ..
  73. ncbi The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions
    Wen Wan Chao
    Department of Biochemical Science and Technology, Institute of Microbiology and Biochemistry, National Taiwan University, Taipei 106, Taiwan, ROC
    J Ethnopharmacol 122:68-75. 2009
    ..In this study, we employed pNF-kappaB-Luc or pIFN-gamma-Luc and BALB/c mice peritoneal macrophages or splenocytes to investigate both the immune and inflammatory effects of six selected plant species.
  74. ncbi The expression of cytokine genes in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of the nonobese diabetic mice
    Nik Soriani Yaacob
    Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia
    J Clin Immunol 24:177-84. 2004
    ..beta, IL-6, and GM-CSF, were increased while the anti-inflammatory cytokine, TGF-beta, decreased in the peritoneal macrophages of nonobese diabetic (NOD) mice. IL-6 expression however decreased when the mice became diabetic...
  75. ncbi Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
    L Soong
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Immunity 4:263-73. 1996
    ..These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite...
  76. ncbi Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro
    Kunal H Bhatt
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 47:861-70. 2010
    ..iNOS) expression and nitric oxide release caused by peptidoglycan from Staphylococcus aureus in mouse peritoneal macrophages. Protein tyrosine kinase inhibitor, genestein and PKCdelta inhibitor, rottlerin attenuated the PGN-induced ..
  77. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
  78. pmc Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages
    Ho Ki Shim
    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul 136 705, Korea
    Exp Mol Med 41:687-94. 2009
    ..In conclusions, these results indicate that Legionella PAL might activate macrophages via a TLR2-dependent mechanism which thus induce cytokine production and expression of costimulatory and MHC molecules...
  79. pmc Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages
    J H Dai
    Department of Microbiology, Yamanashi Medical University, Yamanashi, Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 103:235-43. 2001
    ..LPS)-induced IL-12 p40 and IL-12 p70 (heterodimer of p40 and p35) protein production by peritoneal macrophages (PM)...
  80. ncbi Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    J Interferon Cytokine Res 22:517-26. 2002
    ..current investigation, we demonstrate activation of the p42/44 MAPK-mediated signal transduction in murine peritoneal macrophages on stimulation with MCP-1 (10-100 ng/ml) in vitro...
  81. ncbi Enterococcus spp. produces slime and survives in rat peritoneal macrophages
    L Baldassarri
    Laboratorio di Ultrastrutture, Istituto Superiore di Sanita, Rome, Italy
    Med Microbiol Immunol 190:113-20. 2001
    ..Slime-producing E. faecalis were able to survive inside peritoneal macrophages for extended periods compared to slime-negative strains or to slime-positive bacteria grown in conditions ..
  82. pmc Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor
    Laura M Kreckler
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee, 53226, USA
    J Pharmacol Exp Ther 317:172-80. 2006
    ..the A(2A)AR is the primary AR subtype that suppresses TNF-alpha release from thioglycollate-elicited mouse peritoneal macrophages induced by both Toll-like receptor-dependent (TLR) and TLR-independent stimuli, but we determined that the ..
  83. ncbi Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK
    Christina L Sherry
    Division of Nutritional Sciences, Integrative Immunology and Behavior Program, University of Illinois, 506 South Mathews Avenue, Urbana, IL 61801, USA
    J Immunol 178:663-70. 2007
    ..In this study, we show that augmented LPS-induced TNF-alpha production by resident peritoneal macrophages (PerMphi) in type 2 diabetic (db/db) mice is dependent on elevated glucose and requires p38 MAPK...
  84. ncbi Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
    R Kamijo
    Department of Microbiology, New York University Medical Center, NY 10016
    Science 263:1612-5. 1994
    ..Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages...
  85. pmc Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages
    Kit Wong
    Department of Immunology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 107:8712-7. 2010
    ..It mediates phagocytosis of apoptotic cells by peritoneal macrophages. The in vivo functions of Tim-4 in phagocytosis and immune responses, however, are still unclear...
  86. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
  87. ncbi Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan
    Jie Young Song
    Laboratory of Immunology, Korea Cancer Center Hospital, Seoul, South Korea
    Int Immunopharmacol 2:857-65. 2002
    ..Murine peritoneal macrophages (PM) on in vitro treatment with ginsan isolated from Panax ginseng induced mRNA of cytokines such as tumor ..
  88. pmc TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha
    M Piecyk
    Division of Rheumatology and Immunology, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    EMBO J 19:4154-63. 2000
    ..Mice lacking TIA-1 are hypersensitive to the toxic effects of LPS, indicating that this translational control pathway may regulate the organismal response to microbial stress...
  89. ncbi P2X currents in peritoneal macrophages of wild type and P2X4 -/- mice
    Bert Brône
    Gobal Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B2340 Beerse, Belgium
    Immunol Lett 113:83-9. 2007
    In this study the ATP-induced (P2X) currents in isolated peritoneal macrophages of wild type (WT) and P2X(4) knockout (P2X(4)(-/-)) mice were studied by means of whole-cell patch clamp in order to (1) survey the P2X currents of native ..
  90. pmc Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard 6 638 Basic Science Building, Galveston, TX 77555 0647, USA
    Cytokine 36:115-22. 2006
    ..of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma, and chemokine MCP-1 in murine peritoneal macrophages. Inhibition of AR also prevented the production of nitric oxide, and prostaglandin E2 and expression of ..
  91. ncbi Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages
    Chihiro Mogi
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    J Immunol 182:3243-51. 2009
    ..protein production, which was associated with an inhibition of TNF-alpha mRNA expression, in mouse peritoneal macrophages. The LPS-induced cytokine production was also inhibited by G(s) protein-coupled receptor agonists ..
  92. ncbi Kinetics of the phenotype and function of murine peritoneal macrophages following acute inflammation
    Qingli Wu
    Laboratory of Immunopharmacology and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Cell Mol Immunol 1:57-62. 2004
    ..A comprehensive kinetics of cytokine production was performed in murine peritoneal macrophages recovered from Balb/c mice at various time during the course of an intraperitoneal injection with ..
  93. ncbi Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophages
    H Sato
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575 Japan
    J Biol Chem 276:10407-12. 2001
    Amino acid transport in mouse peritoneal macrophages is mediated by several membrane carriers with different substrate specificity and sensitivity to environmental stimuli...
  94. ncbi Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages
    Wei Xu
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:1594-9. 2007
    ..We propose that pMPhi have the potential to maintain an anti-inflammatory condition in the peritoneal cavity...
  95. ncbi Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
    Cell Signal 15:299-306. 2003
    ..of capsaicin on the production of inflammatory molecules in lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. The level of PGE2 was measured by EIA...
  96. ncbi Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background
    Michael P Vitek
    Division of Neurology, Duke University Medical Center, Durham North Carolina 27710, USA
    Antioxid Redox Signal 8:893-901. 2006
    ..b>Peritoneal macrophages from double transgenic mice generated nanomolar levels of nitrite in response to inflammatory stimuli, ..
  97. ncbi The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Division of General Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Infect Dis 185:1483-9. 2002
    ..In conclusion, TLR4-defective C3H/HeJ mice are more susceptible to C. albicans infection, and this is associated with impaired chemokine expression and neutrophil recruitment...
  98. ncbi Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    R Langenbach
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cell 83:483-92. 1995
    ..Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2...
  99. ncbi Cellular signaling during the macrophage invasion by Trypanosoma cruzi
    Mauricio Vieira
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Histochem Cell Biol 118:491-500. 2002
    ..These achievements support the model for a phagocytic-like actin-dependent invasion mechanism for T. cruzi trypomastigotes into macrophages...
  100. ncbi Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages
    Carol A Rouzer
    Departments of Biochemistry and Chemistry, Vanderbilt Institute for Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
    J Biol Chem 279:34256-68. 2004
    Comprehensive studies of prostaglandin (PG) synthesis in murine resident peritoneal macrophages (RPM) responding to bacterial lipopolysaccharide (LPS) revealed that the primary PGs produced by RPM were prostacyclin and PGE(2)...
  101. ncbi Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
    Charles A Scanga
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5997-6001. 2002
    ..Defective IL-12 responses to T. gondii Ags (soluble tachyzoite Ag (STAg)) were observed in MyD88(-/-) peritoneal macrophages, neutrophils, and splenic dendritic cells (DC)...

Research Grants63

  1. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..It is expressed in human peripheral blood monocytes or mouse peritoneal macrophages following activation with LPS...
  2. Polyamine Metabolism in Leishmania
    Buddy Ullman; Fiscal Year: 2013
    ..test mechanism;2) to perform complementary infectivity studies with the wild type and mutant parasites in peritoneal macrophages derived from the Arg1flox/flox;Tie2cre and Tie2cre strains;3) to establish the role of POT1 in modulating ..
  3. Regulation of Tumor Associated Macrophages by TGF-beta
    Venkateshwar G Keshamouni; Fiscal Year: 2012
    ..Analysis of TAMs purified from wild type mice demonstrated enhanced IRAK-M expression compared to peritoneal macrophages from same mice...
  4. Role of Ion Channel in Mononuclear Phagocyte Activation
    Deborah J Nelson; Fiscal Year: 2012
    ..We will compare the phagocytic and secretory activities of alveolar and peritoneal macrophages as well as neutrophils and the anion channels that are involved in the regulation of these activities...
  5. Aldose Reductase: A Regulator of Inflammatory Signals
    KOTA VENKATA RAMANA; Fiscal Year: 2011
    ..of cytokines such as TNF-alpha, IL-6, and IL-10, secondary messenger cAMP and prostaglandin E2 in mouse peritoneal macrophages. Our hypothesis is that AR plays a pivotal role in the transduction of LPS-induced inflammatory responses ..
  6. Histone deacetylases and atherosclerosis
    Nilamadhab Mishra; Fiscal Year: 2010
    ..We will use thioglyocollate-elicited peritoneal macrophages or bone marrow derived macrophages to study the effect of different levels of expression of HDAC9 on ..
  7. Discovery of 4-aminoquinoline therapeutics for visceral leishmaniasis
    Peter C Melby; Fiscal Year: 2010
    ..against amastigotes in splenic macrophages, which are functionally distinct from the traditionally used peritoneal macrophages, and (5) will be identified as having anti-leishmanial activity whether it is through direct parasite ..
  8. Identification of age-related mediators of pro-inflammatory signaling
    AMANDA OPALUCH; Fiscal Year: 2010
    ..Intriguingly, aged peritoneal macrophages are sensitized to inflammatory stimuli, including LPS...
  9. Morphine and gp120 modulation of Fc gamma mediated macrophage phagocytosis
    Jana Ninkovic; Fiscal Year: 2010
    ..Macrophage cell lines as well as primary peritoneal macrophages treated in vivo and in vitro will e used to show the effects of chronic morphine and gp120 on this ..
  10. Alcohol, the vagus nerve and multi-organ inflammation
    John M Littleton; Fiscal Year: 2012
    ..ligands on endotoxin-induced release of mediators from inflammatory cells (splenic, lung and peritoneal macrophages) from wild-type, and alpha7-nicAChR knock-out, C57Bl/6J mice...
  11. TNF SIGNALING IN THE ABSENCE OF FUNCTIONAL TNF RECEPTORS.
    EDOUARD M CANTIN; Fiscal Year: 2012
    ..We propose using a bifunctional crosslinker coupled to TNF to crosslink the new TNFR (nTNFR) on peritoneal macrophages from dKO mice...
  12. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2012
    ..Aim 2 will determine the physiologic implications of retinoid action on CD36 as relates to peritoneal macrophages from women with endometriosis...
  13. HIV-Human Peritonal Macrophage Interactions
    Theresa L Chang; Fiscal Year: 2012
    ..We recently demonstrate that peritoneal macrophages (PMs) are highly abundant in ascitic fluid of patients with cirrhosis and are susceptible to HIV-1 ..
  14. SRP RNA level as a determinant of leishmanial parasitism of macrophages
    Gautam Chaudhuri; Fiscal Year: 2009
    ..measure the levels of cathepsins in lysosomes, and scavenger receptor, and CSF-1R on the cell surfaces of peritoneal macrophages isolated from transplanted mice after exposure of the macrophages for various time periods (0-12 h)...
  15. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    ..The responses of PDMo are similar to the responses of peritoneal macrophages (PMo) emphasizing the relevance of PDMo to the pathobiology of injury and sepsis...
  16. Campylobacter jejuni and Reactive Nitrogen Species
    Nicole Iovine; Fiscal Year: 2007
    ..To assess the biological significance of these genes, we will measure the ability of peritoneal macrophages from iNOS-null mice to kill RNS-hypersusceptible strains versus the wild-type...
  17. CONTRIBUTION OF LPS TO EXP ENTEROCOCCAL SEPSIS
    Christopher Papasian; Fiscal Year: 2000
    ..that Enterococcus faecalis was a poor inducer of TNF in an in vitro system that examines TNF production in peritoneal macrophages. The investigators hypothesize that Enterococcal species must synergize with bacterial LPS in Gram-..
  18. PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSIS
    CECIL LYTTLE; Fiscal Year: 1993
    ..study is to elucidate the possible mechanism(s) by which this factor modulates the number and activity of peritoneal macrophages in women with endometriosis...
  19. ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTION
    KATHY TIMMS; Fiscal Year: 2006
    ..To test this hypothesis, peritoneal macrophages, and endometriotic lesions when present, will be collected from women without and with endometriosis...
  20. INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGES
    Claudia Gentry Weeks; Fiscal Year: 2003
    ..faecalis isolates are able to survive in mouse peritoneal macrophages, J774A.1 macrophage-like cells, and murine bone marrow derived macrophages for an extended period of time...
  21. Feasibility of Hemin-Based Therapy in Experimental Acute Pancreatitis
    M Omary; Fiscal Year: 2006
    ..This aim also entails exposing peritoneal macrophages to siRNA directed towards HO-1 in order to test if HO-1 activation is important for macrophage protection ..
  22. REGULATION OF THE CARDIOVASCULAR SYSTEM
    WALTER RANDALL; Fiscal Year: 1980
    ..b>Peritoneal macrophages elaborate a mediator which stimulates adipose glucose oxidation...
  23. HIV PROTEASE INHIBITORS AND ATHEROSCLEROSIS
    Eric Smart; Fiscal Year: 2006
    ..Our preliminary data demonstrate that peritoneal macrophages isolated from LDL receptor null mice given the HIV protease inhibitors, amprenavir, indinavir, or ..
  24. IFN-GAMMA IN EXPERIMENTAL MURINE HISTOPLASMOSIS
    BETTY WU HSIEH; Fiscal Year: 1991
    ..The behavior of the fungus within resident murine peritoneal macrophages cultured in vitro has been studied as a cellular model of the host-parasite interaction in histoplasmosis...
  25. PATHOGENIC MECHANISMS OF SHIGA AND SHIGA LIKE TOXINS
    VERNON TESH; Fiscal Year: 1999
    ..We have shown that murine peritoneal macrophages are essentially refractory to the cytotoxic actions of SLTs but respond to toxins by producing ..
  26. CHOLESTERYL ESTER FLUIDITY IN ATHEROSCLEROSIS RESEARCH
    Julian Snow; Fiscal Year: 1991
    ..These cells become the foam cells characteristic of atherosclerotic plaque. Studies with cultured mouse peritoneal macrophages have shown that the cholesteryl esters in these cells are in a dynamic state, continually undergoing a ..
  27. DEVELOPMENT AND REGULATION OF TESTICULAR MACROPHAGES
    JAMES HUTSON; Fiscal Year: 1992
    ..that testicular macrophages produce a factor that stimulates testosterone secretion by Leydig cells while peritoneal macrophages have no effect...
  28. PINOCYTIC REGULATION IN NORMAL AND TRANSFORMED CELLS
    Joel Swanson; Fiscal Year: 1990
    ..Earlier work has shown that in thioglycollate-elicited mouse peritoneal macrophages (TMO), only a small percentage of the great quantity of fluid entering by pinocytosis is sent to lysosomes...
  29. CELL INTERACTIONS IN ENDOMETRIOSIS
    JOHN HASKILL; Fiscal Year: 1992
    ..proposed studies are based on our early observations documenting phenotypic and secretory differences in E peritoneal macrophages as compared to those of normal women (N)...
  30. ARTERIAL WALL PROTEOGLYCANS AND FOAM CELL FORMATION
    Parakat Vijayagopal; Fiscal Year: 1993
    ..Our initial studies show that LDL-PG complex promotes cholesteryl ester deposition in mouse peritoneal macrophages. Therefore, we hypothesize that the uptake of lipoproteins complexed to arterial wall PG by human monocyte-..
  31. HIV protease inhibitors, marcophage function/estrogen
    Melinda Wilson; Fiscal Year: 2007
    ..We will examine the atherosclerotlc lesion size and lipid metabolism in peritoneal macrophages from intact LDL receptor null mice as well as ovariectomized and estrogen replaced female mice...
  32. IMMUNOLOGY AND IMMUNOTHERAPY OF LEPROSY
    James Krahenbuhl; Fiscal Year: 1990
    ..of human (leprosy patients and normals) monocytes and activated monocyte-derived macrophages and mouse peritoneal macrophages on the leprosy bacillus itself...
  33. Ethanol-fed, CpG-treated mice: Listeria susceptibility
    Nancy Ray; Fiscal Year: 2005
    ..monocytogenes by peritoneal macrophages will be examined to determine whether ethanol-fed mice are deficient in killing L...
  34. ANANDAMIDE/THC INDUCED ARACHIDONIC ACID RELEASE
    Sumner Burstein; Fiscal Year: 1999
    ..The systems to be used for these investigations will be isolated, intact cells such as mouse peritoneal macrophages, neuroblastoma and Chinese-hamster ovary lines...
  35. THE FATE OF CYTOCHROME C IN CELL DEATH
    Ronald Jemmerson; Fiscal Year: 2000
    ..Since in vivo apoptotic cells and debris are engulfed by phagocytic cells, the effect of peritoneal macrophages on the appearance of extracellular cyt c will be examined in vitro...
  36. NOVEL ANTISENSE THERAPEUTIC FOR RHEUMATOID ARTHRITIS
    Brian Johnston; Fiscal Year: 1999
    ..administration to mice, specific anti-TNFalpha ATR-lipid complexes inhibited TNFalpha secretion by peritoneal macrophages by 50% relative to an ATR molecule targeted to a heterologous mRNA...
  37. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2007
    ..of the proposed research are: 1) To determine whether induction of matrix metalloproteinases in murine peritoneal macrophages is correlated with exposure to biopersistent, carcinogenic fibers; 2) To assess the contribution of ..
  38. MOLECULAR BASES OF INTERFERON-INDUCED FUNGISTATIS
    DEXTER HOWARD; Fiscal Year: 1993
    ..The cells to be used are resident peritoneal macrophages from the C57BL/6 and C3H/HeJ strains of mice and macrophages from the permanent cell lines P338D,and IC-21...
  39. Macrophage Elastase in Host Defense
    Steven Shapiro; Fiscal Year: 2005
    ..If the mutation is lethal or not fully deficient in pulmonary macrophages, then lung-specific transgenic mice will be used to inducibly express DT in lungs of mature mice. ..
  40. Hyperbaric oxygen and atherosclerosis
    Ladislav Dory; Fiscal Year: 2007
    ..by significant increases in the expression of antioxidant enzymes (ecSOD, Mn-SOD, PON1) in the liver, peritoneal macrophages (ecSOD and GPX3) and the aortic tissue (ecSOD and GPX3)...
  41. DIFFERENTIAL TURNOVER OF MEMBRANE PHOSPHOLIPIDS
    HARALD SCHMID; Fiscal Year: 2000
    ..Under Aim 3 we will compare parameters of phospholipid acyl turnover between rat hepatocytes and mouse peritoneal macrophages. We expect to find similar relationships between de novo synthesis and remodeling of ..
  42. BIOCHEMICAL STUDIES OF A MAJOR OPSONIC PROTEIN
    Janos Molnar; Fiscal Year: 1980
    ..We are using 125I-gelatin coated latex particles (g-Ltx) in conjunction with rat peritoneal macrophages. Our major aims for the next period are: 1) To establish the important kinetic parameters involved in the ..
  43. SURVIVAL AND DEATH OF NEURONS
    TIMOTHY CUNNINGHAM; Fiscal Year: 2003
    ..effects on integrin-mediated functions will be tested in an in vitro chemotaxis chamber with brain and peritoneal macrophages. Second the effects of Y- P30 stimulated release of calreticulin on complement-mediated mechanisms (..
  44. APOE AND ATHEROGENESIS
    ROBERT PITAS; Fiscal Year: 2002
    ..They will compare the ability of peritoneal macrophages and of stably transfected cells expressing ApoE2, ApoE3, or ApoE4 to release cholesterol...
  45. MKP-1 IN Regulation of Inflammatory Cytokine Production
    Yusen Liu; Fiscal Year: 2004
    ..The Fourth Specific Aim is to test the hypothesis that the responses to LPS stimulation of primary peritoneal macrophages from Mkp-1-/- mice differ from the responses of macrophages isolated from Mkp-1+/+ mice...
  46. Macrophage Density Regulates T Cells
    James Riggs; Fiscal Year: 2009
    ..Serendipitously, this work led to the discovery of potent immune suppression mediated by peritoneal macrophages (M?s). We found that M? suppression of T cell activation is mediated by amino acid catabolism...
  47. Role of gp120 in Neuropathogenesis in a New Model of HIV Infection in Mice
    DAVID VOLSKY; Fiscal Year: 2007
    ..infected, with production of antibodies to viral proteins and presence of virus in the spleen, peritoneal macrophages, and PBL...
  48. ALTERED LEUKOTRIENE RELEASE IN PARASITIZED PHAGOCYTES
    William Henderson; Fiscal Year: 1990
    ..We have recently found that resident murine peritoneal macrophages release an altered profile of arachidonic acid metabolites after infection with toxoplasma...
  49. ANALYSIS OF THE PH 6 ANTIGEN OF YERSINIA PESTIS
    STUART PRICE; Fiscal Year: 1991
    ..pestis KIM5 strain, will be used to infect resident murine peritoneal macrophages in culture...
  50. Mkk3/p38 MAPK, Macrophage Apoptosis, and Atherosclerosis
    Tracie Seimon; Fiscal Year: 2007
    ..b>Peritoneal macrophages from wild-type mice, or mice deficient in MKK3 and p38alpha, will be used to ask if this signaling pathway ..
  51. IMMUNE GLOMERULONEPHRITIS?
    George Schreiner; Fiscal Year: 1990
    ..The first parameter to be examined will be the expression of Ia antigens by intraglomerular and peritoneal macrophages in the presence of factors secreted by intrinsic glomerular cells...
  52. Immunoregulation in the Peritoneal Cavity
    James Riggs; Fiscal Year: 2005
    ..Our preliminary studies suggest that peritoneal macrophages and/or dendritic cells, suppress T cell activation via tryptophan catabolism...
  53. BIOLOGICAL ROLE OF HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN
    Jorge Bezerra; Fiscal Year: 1999
    ..MSP is a recently described protein that induces morphologic changes, chemotaxis, and phagocytosis in peritoneal macrophages. Based on these data, Dr...
  54. ROLE OF TRANSGLUTAMINASE IN HORMONE INTERNALIZATION
    Peter Davies; Fiscal Year: 1991
    ..induce dramatic increases in the levels of a specific transglutaminase, tissue transglutaminase, in mouse peritoneal macrophages, human peripheral blood monocytes and human promyelocytic leukemia (HL-60) cells...
  55. MACROPHAGE DYSFUNCTION AFTER TRAUMATIC INJURY
    John Daly; Fiscal Year: 2000
    ..Mechanisms of cellular dysfunction will be studied in resident peritoneal macrophages by: 1) assessing distal functions such as phagocytosis of opsonized beads, PMA 02 production, ..
  56. Role of NEMOBP1 in LPS Stimulated Inflammatory Response
    Ato Wright; Fiscal Year: 2007
    ..plan to determine the role of NEMOBP1 in mediating TLR signaling using bone marrow derived macrophages and peritoneal macrophages obtained from NEMOBP1 knockout and wild type mice...
  57. PURCHASE OF TRIPLE QUADRUPOLE MASS SPECTROMETER
    Alan Sartorelli; Fiscal Year: 1991
    ..will also be used to help characterize the structures of glycosphingolipids and gangliosides in murine peritoneal macrophages. It will also be employed to quantitate steroidal fatty acid esters both in terms of total steroid esters ..
  58. DIFFERENTIATION OF HUMAN MONONUCLEAR PHAGOCYTES
    Warren Johnson; Fiscal Year: 1980
    ..quantitative functional and biochemical activities of normal adult and neonatal monocytes and human peritoneal macrophages with those of in vitro activated monocytes...
  59. HOW PHAGOCYTES DEAL WITH FUNGI
    DEXTER HOWARD; Fiscal Year: 1980
    ..from caseinate and glycogen induced macrophages; from immunized and normal animals; and from alveolar and peritoneal macrophages. 2. Studies with Torulopsis glabrata and Candida pseudotropicalis...
  60. ANIONIC LIPOSOMES FOR GENE DELIVERY TO APCS
    Frank Tagliaferri; Fiscal Year: 2000
    ..g. size, mass/charge ratio). The resulting complexes will be mixed with mouse splenocytes, peritoneal macrophages, isolated dendritic cells, and human PBMC preparations in vitro and analyzed for uptake and expression...
  61. REGULATION OF MACROPHAGE INOS EXPRESSION
    Ming hai Wang; Fiscal Year: 2001
    ..in blocking endotoxin or cytokine-induced expression of inducible nitric oxide synthase (iNOS) by murine peritoneal macrophages, suggesting a dual role in inflammation...
  62. Roles of SLPI in atherosclerosis
    KRISTINE NOWAK; Fiscal Year: 2007
    ..It was shown that SLPI is more highly expressed in elicited peritoneal macrophages from C57BL/6 mice than FVB/N mice...
  63. Adenosine in trauma and sepsis
    Gyorgy Hasko; Fiscal Year: 2007
    ..abstract_text> ..