Genomes and Genes
Summary: Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.
Publications287 found, 100 shown here
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall componentsO Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
Immunity 11:443-51. 1999..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
- A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionH Suzuki
Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
Nature 386:292-6. 1997..In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens...
- Characterization of latent TGF-beta activation by murine peritoneal macrophagesI Nunes
Department of Cell Biology, New York University Medical Center, New York 10016, USA
J Immunol 155:1450-9. 1995..by macrophages was characterized using serum-free cultures of resident and thioglycollate-elicited murine peritoneal macrophages that were either unstimulated or LPS-stimulated in vitro...
- Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene productK Hoshino
Department of Biochemistry, Hyogo College of Medicine, Japan
J Immunol 162:3749-52. 1999..Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ mice activated NF-kappaB. Taken together, the present study demonstrates that TLR4 is the gene product that regulates LPS response...
- Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayMasahiro Yamamoto
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
Science 301:640-3. 2003..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
- Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetateStefan Jung
Klinische Forschungsgruppe für Multiple Sklerose an der Neurologischen Klinik, Julius Maximilians Universitat Wurzburg, Germany
J Neuroimmunol 148:63-73. 2004..Using freshly isolated resident peritoneal macrophages from naive Lewis rats, it is shown that GLAT profoundly modulates cytokine secretion of the cells...
- Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascitesR Frances
Department of Immunology, Hospital General Universitario, Pintor Baeza s n, Alicante, Spain
Gut 53:860-4. 2004..vitro, and we hypothesised that the presence of bacterial DNA could activate the type I immune response in peritoneal macrophages from these patients, leading to greater cytokine synthesis (interleukin (IL)-2 and IL-12, tumour necrosis ..
- Unresponsiveness of MyD88-deficient mice to endotoxinT Kawai
Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
Immunity 11:115-22. 1999....
- Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophagesReiko Okutsu
Free Radical Project, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
Atherosclerosis 204:405-11. 2009..Thus, we investigated the effect of cilostazol on LDL uptake in mouse peritoneal macrophages (MPM)...
- Phenotypic and functional analysis of murine resident and induced peritoneal macrophagesLyubomyr R Turchyn
Department of Comparative Medicine, Pfizer Global Research and Development, Ann Arbor, MI, USA
Comp Med 57:574-80. 2007..Although approximately 1 million peritoneal macrophages can be obtained from an untreated mouse, more than twice that number can be collected 48 to 72 h after ..
- The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophagesViswanathan Saraswathi
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Lipid Res 47:1406-15. 2006..Incubation of mouse peritoneal macrophages with 100 microg/ml VLDL for 6 h led to 2.8- and 3...
- Requirement for transcription factor IRF-1 in NO synthase induction in macrophagesR Kamijo
Department of Microbiology, New York University Medical Center, NY 10016
Science 263:1612-5. 1994..Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages...
- Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitroSantanu Kar Mahapatra
Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721 102, West Bengal, India
Eur J Pharmacol 623:132-40. 2009..aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine...
- Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammationHong Wang
Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
Nature 421:384-8. 2003..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
- Protective effect of polysaccharide fractions from Radix A. sinensis against tert-butylhydroperoxide induced oxidative injury in murine peritoneal macrophagesXingbin Yang
Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi an 710062, China
J Biochem Mol Biol 40:928-35. 2007..sinensis and their antioxidant activities were evaluated in isolated mouse peritoneal macrophages by pretreatment with APFs before exposure to 0.2 mM tertbutylhydroperoxide (t-BHP)...
- Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathwayK Stoffels
Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Onderwijs en Navorsing, Herestraat 49, B 3000 Leuven, Belgium
J Steroid Biochem Mol Biol 103:567-71. 2007..We have previously shown that in murine peritoneal macrophages 1alpha-hydroxylase is highly regulated by immune signals such as IFNgamma and LPS...
- Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteinsOsamu Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
J Immunol 169:10-4. 2002..Taken together, TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides...
- Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis modelKenneth A Howard
Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
Mol Ther 17:162-8. 2009..anti-TNF-alpha Dicer-substrate siRNA (DsiRNA) mediated TNF-alpha knockdown (approximately 66%) in primary peritoneal macrophages in vitro...
- The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cellsY Xia
Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
J Immunol 162:2281-90. 1999..The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans...
- Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in miceRicardo Ambrósio Fock
Experimental Haematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Brazil
Cytokine 40:105-14. 2007..These data lead us to infer that the nutritional state interferes with the activation of macrophages and with the capacity to mount an immune response...
- Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediatorsM D Lehner
Biochemical Pharmacology, University of Konstanz, Konstanz, Germany
J Immunol 166:5161-7. 2001....
- Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancerMakoto Matsui
Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
Cancer Sci 101:1670-7. 2010..delivery system (DDS) using oligomannose-coated liposomes (OMLs), which are effectively taken up by mouse peritoneal macrophages to carry anticancer drugs to omental milky spots known as initial metastatic sites in the peritoneal ..
- Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction eventsS Bhattacharyya
Department of Microbiology, Bose Institute, Calcutta 700 054, India
Infect Immun 69:1499-507. 2001..donovani induces endogenous secretion of murine IL-10, which in turn facilitates the intracellular survival of the protozoan and orchestrates several immunomodulatory roles via selective impairment of PKC-mediated signal transduction...
- IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophagesP Puddu
Laboratorie of Immunology, Istituto Superiore di Sanita, Rome, Italy
J Immunol 159:3490-7. 1997We previously reported that resting mouse peritoneal macrophages (PM) constitutively express low levels of IFN-gamma, whose production is consistently enhanced by exogenous IFN-gamma...
- Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing abilityMiriam Rodriguez-Sosa
Department of Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, D F Mexico 14080, Mexico
Infect Immun 70:3656-64. 2002..Here, we have used peritoneal macrophages (F4/80+) recruited at different times after challenge with Taenia crassiceps as APC and tested their ..
- Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infectionRichard Malley
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:1966-71. 2003..We conclude that the interaction of pneumolysin with TLR4 is critically involved in the innate immune response to pneumococcus...
- A critical role of activin A in maturation of mouse peritoneal macrophages in vitro and in vivoYinan Wang
Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China
Cell Mol Immunol 6:387-92. 2009..that activin A not only increased NO and IL-1beta release, but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo, whereas it did not influence MHC I and MHC II expression...
- Inhibition of nitric oxide and tumor necrosis factor-alpha by moutan cortex in activated mouse peritoneal macrophagesHwan Suck Chung
Purimed R and D Institute, Kyung Hee University, Dongdaemoon gu, Seoul, Korea
Biol Pharm Bull 30:912-6. 2007..production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-gamma-induced expression of inducible nitric oxide synthase (iNOS) and TNF-..
- Intraperitoneal immunization with oligomannose-coated liposome-entrapped soluble leishmanial antigen induces antigen-specific T-helper type immune response in BALB/c mice through uptake by peritoneal macrophagesY Shimizu
Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa 259 1292, Japan
Parasite Immunol 29:229-39. 2007..OML were preferentially and rapidly incorporated into peritoneal macrophages, and the transplantation of macrophages containing SLA-OML into the peritoneal cavity also induced ..
- Yersinia rLcrV and rYopB inhibits the activation of murine peritoneal macrophages in vitroAjit Sodhi
School of Biotechnology, Banaras Hindu University, Varanasi, UP, India
Immunol Lett 99:146-52. 2005..we have reported that rLcrV and rYopB inhibit the production of TNF-alpha, IFN-gamma, and IL-12 in murine peritoneal macrophages. It was also demonstrated that IL-10 and TLR2 signaling pathways and inhibition of MAPK cascade is ..
- Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertilityBarbara H Osborn
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27705, USA
Fertil Steril 77:46-51. 2002Determine whether peritoneal macrophages from women with endometriosis-associated infertility express more inducible nitric oxide synthase (NOS2) and produce more NO than fertile controls.
- CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophagesGerritje J W van der Windt
Center of Infection and Immunity Amsterdam, Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
Infect Immun 78:115-24. 2010..coli-induced abdominal sepsis and to assess the function of CD44 in the activation of primary peritoneal macrophages by E...
- Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitroA Vazquez-Torres
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Exp Med 192:227-36. 2000..These findings demonstrate that macrophages kill Salmonella in a dynamic process that changes over time and requires the generation of both reactive oxidative and nitrosative species...
- Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptorTracie DeVries-Seimon
Department of Medicine, Columbia University, New York, NY 10032, USA
J Cell Biol 171:61-73. 2005..These findings have important implications for understanding how the UPR, MAPKs, and the SRA might conspire to cause macrophage death, lesional necrosis, and plaque destabilization in advanced atherosclerotic lesions...
- Participation of macrophage membrane rafts in Trypanosoma cruzi invasion processE S Barrias
Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, CCS, UFRJ, Ilha do Fundao, 21941 902 Rio de Janeiro, RJ, Brazil
Biochem Biophys Res Commun 363:828-34. 2007..cruzi parasitophorous vacuole. Taken together these data suggest that membrane rafts, including caveolae, are involved in the process of T. cruzi invasion of macrophages...
- Trehalose inhibits inflammatory cytokine production by protecting IkappaB-alpha reduction in mouse peritoneal macrophagesKahoru Taya
Division of Dental Pharmacology, Department of Oral Medical Science, Ohu University School of Dentistry, Koriyama, Fukushima 963 8611, Japan
Arch Oral Biol 54:749-56. 2009The aim of this study was to examine whether trehalose, a disaccharide, could inhibit Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS)-enhanced production of inflammatory cytokines in mouse peritoneal macrophages.
- Effect of mineral trioxide aggregate on cytokine production by peritoneal macrophagesT M B Rezende
Departamento de Dentística Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Int Endod J 38:896-903. 2005..To test the effect of two commercial brands of grey mineral trioxide aggregate (ProRoot and MTA-Angelus) on cytokine production by M1 and M2 inflammatory macrophages...
- Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophagesPalash Mandal
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Immunol 178:2542-8. 2007..These findings demonstrate that LY2/LY3 targets a novel TLR4-linked signaling pathway that selectively couples to the stabilization of FPR1 mRNA...
- IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophagesLei Liu
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
J Interferon Cytokine Res 24:334-42. 2004..stimulated cAMP accumulation and PKA activation in time-dependent and dose-dependent manners in murine peritoneal macrophages. Moreover, IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly ..
- Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosisAli Akoum
Département d obstétrique gynécologie, Faculte de Medecine, Universite Laval, Quebec, Canada
Fertil Steril 77:989-94. 2002To assess spontaneous and stimulated secretion of monocyte chemotactic protein-1 (MCP-1) and macrophage migration inhibitory factor (MIF) by peritoneal macrophages in women with and without endometriosis.
- Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infectionL Soong
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Immunity 4:263-73. 1996..These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite...
- The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populationsG Grigoriadis
The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria, Australia
EMBO J 15:7099-107. 1996..Stimulated Rel-/- resident peritoneal macrophages produced higher than normal levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), ..
- The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractionsWen Wan Chao
Department of Biochemical Science and Technology, Institute of Microbiology and Biochemistry, National Taiwan University, Taipei 106, Taiwan, ROC
J Ethnopharmacol 122:68-75. 2009..In this study, we employed pNF-kappaB-Luc or pIFN-gamma-Luc and BALB/c mice peritoneal macrophages or splenocytes to investigate both the immune and inflammatory effects of six selected plant species.
- The expression of cytokine genes in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of the nonobese diabetic miceNik Soriani Yaacob
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia
J Clin Immunol 24:177-84. 2004..beta, IL-6, and GM-CSF, were increased while the anti-inflammatory cytokine, TGF-beta, decreased in the peritoneal macrophages of nonobese diabetic (NOD) mice. IL-6 expression however decreased when the mice became diabetic...
- IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophagesPatrizia Puddu
Department of Cell Biology and Neurosciences, Viale Regina Elena 299, 00161 Rome, Italy
J Leukoc Biol 78:686-95. 2005..capable of activating certain macrophage functions, on interferon (IFN)-gamma expression in resting mouse peritoneal macrophages (PM). IL-2 addition to PM from different mouse strains up-modulated IFN-gamma mRNA and protein secretion...
- Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infectionO Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
J Immunol 165:5392-6. 2000..aureus infection, with more enhanced susceptibility in MyD88-deficient mice. Peritoneal macrophages from MyD88-deficient mice did not produce any detectable levels of cytokines in response to S. aureus...
- Glycyrrhizin enhances interleukin-12 production in peritoneal macrophagesJ H Dai
Department of Microbiology, Yamanashi Medical University, Yamanashi, Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Immunology 103:235-43. 2001..LPS)-induced IL-12 p40 and IL-12 p70 (heterodimer of p40 and p35) protein production by peritoneal macrophages (PM)...
- Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathwayHiroaki Hemmi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nat Immunol 3:196-200. 2002..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
- Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activationAjit Sodhi
School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
J Interferon Cytokine Res 22:517-26. 2002..current investigation, we demonstrate activation of the p42/44 MAPK-mediated signal transduction in murine peritoneal macrophages on stimulation with MCP-1 (10-100 ng/ml) in vitro...
- Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophagesHo Ki Shim
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul 136 705, Korea
Exp Mol Med 41:687-94. 2009..In conclusions, these results indicate that Legionella PAL might activate macrophages via a TLR2-dependent mechanism which thus induce cytokine production and expression of costimulatory and MHC molecules...
- Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitroKunal H Bhatt
School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
Mol Immunol 47:861-70. 2010..iNOS) expression and nitric oxide release caused by peptidoglycan from Staphylococcus aureus in mouse peritoneal macrophages. Protein tyrosine kinase inhibitor, genestein and PKCdelta inhibitor, rottlerin attenuated the PGN-induced ..
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsJ Han
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Science 265:808-11. 1994..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
- Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophagesS Akashi
Department of Immunology, Saga Medical School, Nabeshima, Japan
J Immunol 164:3471-5. 2000..Thioglycolate-elicited peritoneal macrophages expressed TLR4-MD-2, which was rapidly down-regulated in the presence of LPS...
- Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophagesChu Sook Kim
Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
Cell Signal 15:299-306. 2003..of capsaicin on the production of inflammatory molecules in lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages. The level of PGE2 was measured by EIA...
- P2X currents in peritoneal macrophages of wild type and P2X4 -/- miceBert Brône
Gobal Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B2340 Beerse, Belgium
Immunol Lett 113:83-9. 2007In this study the ATP-induced (P2X) currents in isolated peritoneal macrophages of wild type (WT) and P2X(4) knockout (P2X(4)(-/-)) mice were studied by means of whole-cell patch clamp in order to (1) survey the P2X currents of native ..
- TIA-1 is a translational silencer that selectively regulates the expression of TNF-alphaM Piecyk
Division of Rheumatology and Immunology, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
EMBO J 19:4154-63. 2000..Mice lacking TIA-1 are hypersensitive to the toxic effects of LPS, indicating that this translational control pathway may regulate the organismal response to microbial stress...
- Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophagesWei Xu
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 37:1594-9. 2007..We propose that pMPhi have the potential to maintain an anti-inflammatory condition in the peritoneal cavity...
- FcR gamma chain deletion results in pleiotrophic effector cell defectsT Takai
DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
Cell 76:519-29. 1994..These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses...
- Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsanJie Young Song
Laboratory of Immunology, Korea Cancer Center Hospital, Seoul, South Korea
Int Immunopharmacol 2:857-65. 2002..Murine peritoneal macrophages (PM) on in vitro treatment with ginsan isolated from Panax ginseng induced mRNA of cytokines such as tumor ..
- Altered immune responses in mice lacking inducible nitric oxide synthaseX Q Wei
Department of Immunology, University of Glasgow, UK
Nature 375:408-11. 1995..The mutant mice showed reduced nonspecific inflammatory response to carrageenin, and were resistant to lipopolysaccharide-induced mortality...
- Survival of Enterococcus faecalis in mouse peritoneal macrophagesC R Gentry-Weeks
Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
Infect Immun 67:2160-5. 1999Enterococcus faecalis was tested for the ability to persist in mouse peritoneal macrophages in two separate studies. In the first study, the intracellular survival of serum-passaged E...
- Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cellsCharles A Scanga
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:5997-6001. 2002..Defective IL-12 responses to T. gondii Ags (soluble tachyzoite Ag (STAg)) were observed in MyD88(-/-) peritoneal macrophages, neutrophils, and splenic dendritic cells (DC)...
- Cellular signaling during the macrophage invasion by Trypanosoma cruziMauricio Vieira
Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, RJ, Brazil
Histochem Cell Biol 118:491-500. 2002..These achievements support the model for a phagocytic-like actin-dependent invasion mechanism for T. cruzi trypomastigotes into macrophages...
- Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responsesR S Byrum
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599 7248, USA
J Exp Med 185:1065-75. 1997....
- Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2Shunzhong Bao
Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Biol Chem 282:27100-14. 2007....
- Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophagesSven Wehner
Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, University of Bonn, Bonn, Germany
Am J Physiol Gastrointest Liver Physiol 299:G1187-97. 2010..Purified iSMC and primary peritoneal macrophages (pMacs) were subjected to static or cyclic strain, and gene expression of inducible nitric oxide synthase (..
- Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophagesCarol A Rouzer
Departments of Biochemistry and Chemistry, Vanderbilt Institute for Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
J Biol Chem 279:34256-68. 2004Comprehensive studies of prostaglandin (PG) synthesis in murine resident peritoneal macrophages (RPM) responding to bacterial lipopolysaccharide (LPS) revealed that the primary PGs produced by RPM were prostacyclin and PGE(2)...
- Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophagesRobson Coutinho-Silva
Autonomic Neuroscience Institute, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Biochem Pharmacol 69:641-55. 2005..These techniques also demonstrated the presence of mRNA for P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors along with protein expression for the three subtypes we investigated, namely, P2Y(1), P2Y(2) and P2Y(4)...
- Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulcerationR Langenbach
Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cell 83:483-92. 1995..Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2...
- Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cellsYoungHee Kim
Korea Nanobiotechnology Center, College of Natural Sciences, Pusan National University, 609 735, Busan, Republic of Korea
Biochem Biophys Res Commun 314:695-703. 2004..Using mouse peritoneal macrophages and RAW 264...
- IL-10 signaling blockade controls murine West Nile virus infectionFengwei Bai
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS Pathog 5:e1000610. 2009..In conclusion, IL-10 signaling plays a negative role in immunity against WNV infection, and blockade of IL-10 signaling by genetic or pharmacologic means helps to control viral infection, suggesting a novel anti-WNV therapeutic strategy...
- Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosisBarbara Balestrieri
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:6691-8. 2006..the action of cytosolic phospholipase A2(cPLA2) alpha in regulating eicosanoid biosynthesis by mouse peritoneal macrophages stimulated with zymosan (Satake, Y., Diaz, B. L., Balestrieri, B., Lam, B. K., Kanaoka, Y., Grusby, M. J...
- SOCS1/JAB is a negative regulator of LPS-induced macrophage activationIchiko Kinjyo
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Immunity 17:583-91. 2002..Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity...
- Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzoneL P Shornick
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 183:1427-36. 1996..Endotoxin-stimulated peritoneal macrophages from IL-1beta-deficient mice showed normal synthesis and cellular release of IL-1alpha after treatment ..
- Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophagesChigusa Nakahashi
Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
J Immunol 178:765-70. 2007..amount of the inflammatory cytokines TNF-alpha and IL-6 from DAP12(-/-) as well as wild-type (WT) peritoneal macrophages. We show that MAIR-II associates with not only DAP12 but also FcRgamma chain homodimers in peritoneal ..
- TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathwayC D Dumitru
Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
Cell 103:1071-83. 2000..LPS stimulation of peritoneal macrophages from these mice did not activate MEK1, ERK1, and ERK2 but did activate JNK, p38 MAPK, and NF-kappaB...
- Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophagesC A Louis
Department of Surgery, Division of Surgical Research, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
Am J Physiol 276:R237-42. 1999..Moreover, they suggest that a decrease in intracellular L-arginine concentration resulting from its consumption by arginase may be repaired by concurrent increases in L-arginine influx into the cell...
- Upregulation of lipopolysaccharide-induced interleukin-10 by prostaglandin A1 in mouse peritoneal macrophagesHyo Young Kim
Department of Microbiology College of Medicine, Yeungnam University, Daegu, Korea
J Microbiol Biotechnol 18:1170-8. 2008..of action of PGA1 in lipopolysaccharide (LPS)-induced expression of interleukin (IL)-10 mRNA in mouse peritoneal macrophages. 15d-PGJ2 inhibited expression of LPSinduced IL-10, whereas PGA1 increased LPS-induced IL-10 expression...
- Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3Stephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
J Immunol 173:2715-24. 2004..Phosphorylation of p38 kinase in peritoneal macrophages (F4/80(+)) was suppressed, as was nuclear translocation of p-c-Jun and p65 in peritoneal cells...
- Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophagesMauricio Alvarez
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
Curr Biol 16:2161-5. 2006....
- Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophagesMasayuki Yoshikawa
Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
Bioorg Med Chem 14:456-63. 2006..and falcarindiol] substantially inhibited LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages, and isoepoxypteryxin inhibited D-GalN-induced cytotoxicity in primary cultured rat hepatocytes...
- Effects of activin A on the activities of the mouse peritoneal macrophagesXue Jun Zhang
Department of Immunology, School of Basic Medical Sciences, Jilin University, Changchun, China
Cell Mol Immunol 2:63-7. 2005..activin A on the activities of mouse macrophages, the secretion of NO in the supernatant of cultured mouse peritoneal macrophages was examined by NO assay kit, and the expression of iNOS, ActRIIA and ARIP2 mRNA in mouse peritoneal ..
- Increased activation of nuclear factor-kappa B (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosisJean Christophe Lousse
Fonds de la Recherche Scientifique, FNRS, Belgium
Fertil Steril 90:217-20. 2008Endometriosis is characterized by pelvic inflammation that shows an increased number of activated peritoneal macrophages and their secreted products such as cytokines, growth factors, and angiogenic factors...
- Crotalus durissus terrificus snake venom regulates macrophage metabolism and functionS C Sampaio
Laboratory of Pathophysiology, Butantan Institute, , Brazil
J Leukoc Biol 70:551-8. 2001..This cell activation state does not include inflammatory properties of spreading and phagocytosis...
- Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophagesTetsuji Nakano
Second Department of Internal Medicine, Oita Medical University, Hasama, Oita 879 5593, Japan
Antimicrob Agents Chemother 47:363-7. 2003..Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages...
- Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophagesH Shinji
Department of Microbiology II, The Jikei University School of Medicine, Tokyo, Japan
J Immunol 158:1370-6. 1997..The results also suggest that the later IP3 change is considered to be mediated through a gamma2 type of phosphatidylinositol-specific PLC...
- Enhancement of phagocytosis by corticostatin I (CSI) in cultured mouse peritoneal macrophagesM Ichinose
Department of Physiology, Shimane Medical University, Izumo, Japan
Immunopharmacology 35:103-9. 1996..To clarify the function of CSI on the immune system, the effect of CSI on phagocytosis by peritoneal macrophages was examined by means of flow cytofluorometry...
- Heat shock response inhibits IL-18 expression through the JNK pathway in murine peritoneal macrophagesYun Wang
Department of Cell Biology, The Third Military Medical University, Chongqing 400038, China
Biochem Biophys Res Commun 296:742-8. 2002..The augmentation of LPS-induced IL-18 mRNA and protein was significantly suppressed in murine peritoneal macrophages after 43 degrees C heat shock treatment...
- Expression of Nocardia brasiliensis superoxide dismutase during the early infection of murine peritoneal macrophagesAgnes Revol
Departamento de Inmunologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico
Can J Microbiol 52:1255-60. 2006..developed, allowing comparison of bacterial sod expression in exponential culture and 1 h after infecting peritoneal macrophages from BALB/c mice. At that time, there were viable bacteria in the macrophages...
- A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosisDana G Mordue
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
J Leukoc Biol 74:1015-25. 2003..Our findings suggest that activated CD68+/Gr-1+ macrophages contribute to parasite control during infection by directly inhibiting parasite replication and through production of T helper cell type I cytokines...
- [Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro]Peng yun Wang
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
Beijing Da Xue Xue Bao 37:569-74. 2005To compare the immunomodulatory effects of spore polysaccharides (Gl-SP) and broken spore polysaccharides (Gl-BSP) isolated from Ganoderma lucidum(Leyss et Fr.) Karst. on murine splenic lymphocytes and peritoneal macrophages in vitro.
- Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophagesC D Jun
Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Korea
J Immunol 154:6541-7. 1995....
- Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophagesWendy Imlach
Virus Research Unit and Centre for Gene Research, Department of Microbiology, University of Otago, PO Box 56, Dunedin, New Zealand
J Gen Virol 83:1049-58. 2002..murine mast cells (MC/9) and inhibits tumour necrosis factor-alpha synthesis in activated mouse peritoneal macrophages. Our results demonstrate that although ORFV-IL-10 is structurally similar to EBV-IL-10 it has evolved a ..
- Induction of secretory and tumoricidal activities in peritoneal macrophages activated by an acidic heteropolysaccharide (ARAGAL) from the gum of Anadenanthera colubrina (Angico branco)Mariana Piemonte Moretão
Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531 990 Curitiba, Parana, PR, Brazil
Immunol Lett 93:189-97. 2004..It has been demonstrated that activation of mice peritoneal macrophages both in vivo and in vitro, increases phagocytic ability and anion superoxide production...
- Advanced glycation end products stimulate tumor necrosis factor-alpha and interleukin-1 beta secretion by peritoneal macrophages in patients on continuous ambulatory peritoneal dialysisGloria Rashid
Department of Nephrology and Hypertension, Sapir Medical Center, Kfar Saba, Israel
Isr Med Assoc J 8:36-9. 2006..AGE-modified 132m has also been shown to enhance chemotaxis and increase tumor necrosis factor-alpha and interleukin-1 beta secretion by circulating and tissue monocytes/macrophages...
- Improvement by several antioxidants of macrophage function in vitroM Del Rio
Department of Animal Physiology, Biology Faculty, Complutense University of Madrid, Spain
Life Sci 63:871-81. 1998..acid (TCA), at different concentrations, on the various steps of the phagocytic process of murine peritoneal macrophages, i.e...
- Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammationElzbieta Kolaczkowska
Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
Arch Immunol Ther Exp (Warsz) 57:459-66. 2009..The aim was thus to verify the expression and activity of the COX isoforms in resident peritoneal mast cells and macrophages during acute peritonitis...
- Bovine dialyzable leukocyte extract modulates the nitric oxide and pro-inflammatory cytokine production in lipopolysaccharide-stimulated murine peritoneal macrophages in vitroMoisés A Franco-Molina
Departamento de Inmunología y Virología, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Nuevo Leon, Mexico
J Med Food 8:20-6. 2005..In this study, to determine whether bDLE modulates NO and pro-inflammatory cytokine production, murine peritoneal macrophages were treated with bDLE (0.05 or 0...
- Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of DouglasK Werner
Department of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
Prostaglandins Leukot Essent Fatty Acids 67:397-404. 2002Cytochrome P450 metabolism of arachidonic acid (AA) was investigated in human peritoneal macrophages which play a central role in chronic pelvic diseases in women (for example in endometriosis)...
- Effect of angiotensin II and losartan on the phagocytic activity of peritoneal macrophages from Balb/C micePaula Belline
Disciplinas de Nefrologia e Medicina Interna, Nucleo de Medicina e Cirurgia Experimental, Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 970 Campinas, SP, Brasil
Mem Inst Oswaldo Cruz 99:167-72. 2004..In this study, the effect of AII on the phagocytic activity of mouse peritoneal macrophages was assessed...
- Enterococcus spp. produces slime and survives in rat peritoneal macrophagesL Baldassarri
Laboratorio di Ultrastrutture, Istituto Superiore di Sanita, Rome, Italy
Med Microbiol Immunol 190:113-20. 2001..Slime-producing E. faecalis were able to survive inside peritoneal macrophages for extended periods compared to slime-negative strains or to slime-positive bacteria grown in conditions ..
- Project 1: In vitro Studies: Correlate the physical and chemical characteristicsDavid L Eaton; Fiscal Year: 2011..green fluorescent protein (eGFP) were similarly shown to induce an inflammatory response in cultured mouse peritoneal macrophages in vitro, and in vivo after intraperitoneal injection in mice ...
- SRP RNA level as a determinant of leishmanial parasitism of macrophagesGautam Chaudhuri; Fiscal Year: 2009..measure the levels of cathepsins in lysosomes, and scavenger receptor, and CSF-1R on the cell surfaces of peritoneal macrophages isolated from transplanted mice after exposure of the macrophages for various time periods (0-12 h)...
- ROLE OF EICOSANOIDS IN SHOCKJames Cook; Fiscal Year: 1990..in arachidonic acid content; its uptake into and release from phospholipids and phospholipase activity of peritoneal macrophages from rates following endotoxemia and the induction of endotoxin tolerance...
- EFFECT OF MARIJUANA ON MACROPHAGE ANTIGEN PRESENTATIONGuy Cabral; Fiscal Year: 1992..The (B6C3)F1 mouse will be employed for in vivo drug exposure and as a source of peritoneal macrophages. The macrophage line P388D1 will be used for in vitro experiments...
- EFFECT OF MARIJUANA ON MACROPHAGE ANTIGEN PRESENTATIONGuy Cabral; Fiscal Year: 1993..The (B6C3)F1 mouse will be employed for in vivo drug exposure and as a source of peritoneal macrophages. The macrophage line P388D1 will be used for in vitro experiments...
- EFFECT OF MARIJUANA ON MACROPHAGE ANTIGEN PRESENTATIONGuy Cabral; Fiscal Year: 1991..The (B6C3)F1 mouse will be employed for in vivo drug exposure and as a source of peritoneal macrophages. The macrophage line P388D1 will be used for in vitro experiments...
- IMMUNOLOGICAL ASPECTS OF HEMORRHAGEIrshad Chaudry; Fiscal Year: 1990..These parameters will also be measured in peritoneal macrophages and splenic adherent cells...
- PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSISCECIL LYTTLE; Fiscal Year: 1992..study is to elucidate the possible mechanism(s) by which this factor modulates the number and activity of peritoneal macrophages in women with endometriosis...
- PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSISCECIL LYTTLE; Fiscal Year: 1993..study is to elucidate the possible mechanism(s) by which this factor modulates the number and activity of peritoneal macrophages in women with endometriosis...
- Discovery of 4-aminoquinoline therapeutics for visceral leishmaniasisPeter C Melby; Fiscal Year: 2010..against amastigotes in splenic macrophages, which are functionally distinct from the traditionally used peritoneal macrophages, and (5) will be identified as having anti-leishmanial activity whether it is through direct parasite ..
- MYELOPOIETIC STIMULATION FOLLOWING BURN INJURYRichard Gamelli; Fiscal Year: 2006..The responses of PDMo are similar to the responses of peritoneal macrophages (PMo) emphasizing the relevance of PDMo to the pathobiology of injury and sepsis...
- MYELOPOIETIC STIMULATION FOLLOWING BURN INJURYRichard Gamelli; Fiscal Year: 2007..The responses of PDMo are similar to the responses of peritoneal macrophages (PMo) emphasizing the relevance of PDMo to the pathobiology of injury and sepsis...
- MYELOPOIETIC STIMULATION FOLLOWING BURN INJURYRichard Gamelli; Fiscal Year: 2005..The responses of PDMo are similar to the responses of peritoneal macrophages (PMo) emphasizing the relevance of PDMo to the pathobiology of injury and sepsis...
- MYELOPOIETIC STIMULATION FOLLOWING BURN INJURYRichard Gamelli; Fiscal Year: 2004
- Group V sPla2 in Inflammation and Innate ImmunityBarbara Balestrieri; Fiscal Year: 2007..Using group V secretory PLA2 (sPLA2)-null mouse peritoneal macrophages we showed that group V sPLA2 amplifies the action of cytosolic PLA2alpha (cPLA2 alpha) in regulating ..
- Group V sPla2 in Inflammation and Innate ImmunityBarbara Balestrieri; Fiscal Year: 2009..Using group V secretory PLA2 (sPLA2)-null mouse peritoneal macrophages we showed that group V sPLA2 amplifies the action of cytosolic PLA2alpha (cPLA2 alpha) in regulating ..
- Group V sPla2 in Inflammation and Innate ImmunityBarbara Balestrieri; Fiscal Year: 2010..Using group V secretory PLA2 (sPLA2)-null mouse peritoneal macrophages we showed that group V sPLA2 amplifies the action of cytosolic PLA2alpha (cPLA2 alpha) in regulating ..
- CONTRIBUTION OF LPS TO EXP ENTEROCOCCAL SEPSISChristopher Papasian; Fiscal Year: 2000..that Enterococcus faecalis was a poor inducer of TNF in an in vitro system that examines TNF production in peritoneal macrophages. The investigators hypothesize that Enterococcal species must synergize with bacterial LPS in Gram-..
- Campylobacter jejuni and Reactive Nitrogen SpeciesNicole Iovine; Fiscal Year: 2005..To assess the biological significance of these genes, we will measure the ability of peritoneal macrophages from iNOS-null mice to kill RNS-hypersusceptible strains versus the wild-type...
- Campylobacter jejuni and Reactive Nitrogen SpeciesNicole Iovine; Fiscal Year: 2006..To assess the biological significance of these genes, we will measure the ability of peritoneal macrophages from iNOS-null mice to kill RNS-hypersusceptible strains versus the wild-type...
- Campylobacter jejuni and Reactive Nitrogen SpeciesNicole Iovine; Fiscal Year: 2007..To assess the biological significance of these genes, we will measure the ability of peritoneal macrophages from iNOS-null mice to kill RNS-hypersusceptible strains versus the wild-type...
- ROLE OF EICOSANOIDS IN SHOCKJames Cook; Fiscal Year: 1993..specific G proteins transducing lipid A (the toxic moiety of LPS) stimulation of eicosanoids in rat peritoneal macrophages. The mechanism(s) of lipid A induced increases in macrophage membrane GTPase and of reduced GTPase ..
- ROLE OF EICOSANOIDS IN SHOCKJames Cook; Fiscal Year: 1992..specific G proteins transducing lipid A (the toxic moiety of LPS) stimulation of eicosanoids in rat peritoneal macrophages. The mechanism(s) of lipid A induced increases in macrophage membrane GTPase and of reduced GTPase ..
- ROLE OF EICOSANOIDS IN SHOCKJames Cook; Fiscal Year: 1991..specific G proteins transducing lipid A (the toxic moiety of LPS) stimulation of eicosanoids in rat peritoneal macrophages. The mechanism(s) of lipid A induced increases in macrophage membrane GTPase and of reduced GTPase ..
- DIETARY FATTY ACIDS, EICOSANOIDS AND MACROPHAGE FUNCTIONKent Erickson; Fiscal Year: 1990..of functional and differentiation markers, tumoricidal activation, and fatty acid composition of murine peritoneal macrophages in mice fed experimental diets...
- Effects of Curcumin Analogs for the Treatment of EndometriosisFRIEDRICH ALFRED WIESER; Fiscal Year: 2010..Mechanistic studies will be performed on peritoneal macrophages from thioglycollate treated mice to evaluate anti-inflammatory and antiangiogenic effects of curcumin ..
- MECHANISM OF ACTION OF GRANULOCYTE-MACROPHAGE CSFDavid Coleman; Fiscal Year: 1992..In recent experiments, we have successfully transfected peritoneal macrophages with an Egr-1-chloramphenicol acetyltransferase reporter construct using DEAE-dextran...
- ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTIONKATHY TIMMS; Fiscal Year: 2005..To test this hypothesis, peritoneal macrophages, and endometriotic lesions when present, will be collected from women without and with endometriosis...
- ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTIONKATHY TIMMS; Fiscal Year: 2006..To test this hypothesis, peritoneal macrophages, and endometriotic lesions when present, will be collected from women without and with endometriosis...
- ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTIONKATHY TIMMS; Fiscal Year: 2003..To test this hypothesis, peritoneal macrophages, and endometriotic lesions when present, will be collected from women without and with endometriosis...
- ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTIONKATHY TIMMS; Fiscal Year: 2004
- Role of Ion Channel in Mononuclear Phagocyte ActivationDeborah Nelson; Fiscal Year: 2009..We will compare the phagocytic and secretory activities of alveolar and peritoneal macrophages as well as neutrophils and the anion channels that are involved in the regulation of these activities...
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 2003..faecalis isolates are able to survive in mouse peritoneal macrophages, J774A.1 macrophage-like cells, and murine bone marrow derived macrophages for an extended period of time...
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 2002..faecalis isolates are able to survive in mouse peritoneal macrophages, J774A.1 macrophage-like cells, and murine bone marrow derived macrophages for an extended period of time...
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 1999..faecalis isolates are able to survive in mouse peritoneal macrophages, J774A.1 macrophage-like cells, and murine bone marrow derived macrophages for an extended period of time...
- PATHOGENIC MECHANISMS OF SHIGA AND SHIGA LIKE TOXINSVERNON TESH; Fiscal Year: 1999..We have shown that murine peritoneal macrophages are essentially refractory to the cytotoxic actions of SLTs but respond to toxins by producing ..
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 2000
- BIOCOMPATIBLE MEMBRANES FOR ISLET XENOGRAFTSPeter Dervan; Fiscal Year: 1992..be assessed in vivo with islet-free microcapsules in nondiabetic hamsters by measuring the appearance of peritoneal macrophages post-implantation, the attachment of cells to and collagen synthesis upon the microcapsule membranes, and ..
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 2001
- NOVEL ANTISENSE THERAPEUTIC FOR RHEUMATOID ARTHRITISBrian Johnston; Fiscal Year: 1999..administration to mice, specific anti-TNFalpha ATR-lipid complexes inhibited TNFalpha secretion by peritoneal macrophages by 50% relative to an ATR molecule targeted to a heterologous mRNA...
- Retinoid effects on inflammation and cell growth associated with endometriosisNeil Sidell; Fiscal Year: 2010..Aim 2 will determine the physiologic implications of retinoid action on CD36 as relates to peritoneal macrophages from women with endometriosis...
- Retinoid effects on inflammation and cell growth associated with endometriosisNeil Sidell; Fiscal Year: 2010..Aim 2 will determine the physiologic implications of retinoid action on CD36 as relates to peritoneal macrophages from women with endometriosis...
- Retinoid effects on inflammation and cell growth associated with endometriosisNeil Sidell; Fiscal Year: 2009..Aim 2 will determine the physiologic implications of retinoid action on CD36 as relates to peritoneal macrophages from women with endometriosis...
- MACROPHAGE CHOLESTEROL EFFLUX IN ATHEROSCLEROSISRICHARD ST CLAIR; Fiscal Year: 1993..This is accomplished by loading elicited pigeon peritoneal macrophages in vitro with cholesteryl esters or using macrophages from hypercholesterolemic pigeons that are already ..
- FIBRIN COMPLEXES IN INTERMEDIARY COAGULATIONJOHN SHAINOFF; Fiscal Year: 1990..cell lines which bind monomer and NDSK preparations of fibrin with specificities identical to peritoneal macrophages. These studies will be aided by highly selective modifications of fibrin and fibrin derivatives for ..
- Feasibility of Hemin-Based Therapy in Experimental Acute PancreatitisM Omary; Fiscal Year: 2005..This aim also entails exposing peritoneal macrophages to siRNA directed towards HO-1 in order to test if HO-1 activation is important for macrophage protection ..
- Feasibility of Hemin-Based Therapy in Experimental Acute PancreatitisM Omary; Fiscal Year: 2006..This aim also entails exposing peritoneal macrophages to siRNA directed towards HO-1 in order to test if HO-1 activation is important for macrophage protection ..
- PROCESSING OF AIDS RELATED MYCOBACTERIAL ANTIGENSWILLIAM BARROW; Fiscal Year: 1990..Purified radiolabeled GPL antigens will be used to pulse both normal and "activated" peritoneal macrophages which will subsequently be examined for potential GPL-catabolites...
- ACTIVATION OF MACROPHAGES BY VITAMIN D-BINDING PROTEINNobuto Yamamoto; Fiscal Year: 1992..enzymatically generated macrophage activating factor resulted in greatly enhanced ingestion activity of peritoneal macrophages. In the present application we propose to identify the domain within the Gc protein that is responsible ..
- CD14 AND THE IMMUNOPATHOGENESIS OF CHRONIC LYME DISEASETIMOTHY SELLATI; Fiscal Year: 2004..Furthermore, peritoneal macrophages from CD14-deficient mice produced more proinflammatory TNF-alpha and less anti-inflammatory IL-10 than ..
- INFLAMMATORY NEUROLOGICAL DISEASESIain Campbell; Fiscal Year: 2001..of astrocytes and microglial cells (both of which he has demonstrated to make IL12 on LPS stimulation) and peritoneal macrophages. He will define the time course of IL12 induction by LPS, attempt to define the mechanism of secretion ..
- CD14 AND THE IMMUNOPATHOGENESIS OF CHRONIC LYME DISEASETIMOTHY SELLATI; Fiscal Year: 2007..Furthermore, peritoneal macrophages from CD14-deficient mice produced more proinflammatory TNF-alpha and less anti-inflammatory IL-10 than ..
- REGULATION OF THE CARDIOVASCULAR SYSTEMWALTER RANDALL; Fiscal Year: 1980..b>Peritoneal macrophages elaborate a mediator which stimulates adipose glucose oxidation...
- INFLAMMATORY NEUROLOGICAL DISEASESIain Campbell; Fiscal Year: 2000..of astrocytes and microglial cells (both of which he has demonstrated to make IL12 on LPS stimulation) and peritoneal macrophages. He will define the time course of IL12 induction by LPS, attempt to define the mechanism of secretion ..
- HIV PROTEASE INHIBITORS AND ATHEROSCLEROSISEric Smart; Fiscal Year: 2006..Our preliminary data demonstrate that peritoneal macrophages isolated from LDL receptor null mice given the HIV protease inhibitors, amprenavir, indinavir, or ..
- CD14 AND THE IMMUNOPATHOGENESIS OF CHRONIC LYME DISEASETIMOTHY SELLATI; Fiscal Year: 2005..Furthermore, peritoneal macrophages from CD14-deficient mice produced more proinflammatory TNF-alpha and less anti-inflammatory IL-10 than ..
- HIV PROTEASE INHIBITORS AND ATHEROSCLEROSISEric Smart; Fiscal Year: 2005..Our preliminary data demonstrate that peritoneal macrophages isolated from LDL receptor null mice given the HIV protease inhibitors, amprenavir, indinavir, or ..
- HIV PROTEASE INHIBITORS AND ATHEROSCLEROSISEric Smart; Fiscal Year: 2004..Our preliminary data demonstrate that peritoneal macrophages isolated from LDL receptor null mice given the HIV protease inhibitors, amprenavir, indinavir, or ..
- INFLAMMATORY NEUROLOGICAL DISEASESIain Campbell; Fiscal Year: 1999..of astrocytes and microglial cells (both of which he has demonstrated to make IL12 on LPS stimulation) and peritoneal macrophages. He will define the time course of IL12 induction by LPS, attempt to define the mechanism of secretion ..
- HIV PROTEASE INHIBITORS AND ATHEROSCLEROSISEric Smart; Fiscal Year: 2003
- CD14 AND THE IMMUNOPATHOGENESIS OF CHRONIC LYME DISEASETIMOTHY SELLATI; Fiscal Year: 2006
- HIV PROTEASE INHIBITORS AND ATHEROSCLEROSISEric Smart; Fiscal Year: 2002
- ALCOHOL EFFECT ON SERUM APOLIPOPROTEINSRENEE LIN; Fiscal Year: 1993..acceptor from cholesterol-loaded macrophages, 4) to study the effects of alcohol on cholesterol loading in peritoneal macrophages and Kupffer cells and on their ability to synthesize and secrete apo E in response to cholesterol loading, ..
- ALCOHOL EFFECT ON SERUM APOLIPOPROTEINSRENEE LIN; Fiscal Year: 1992..acceptor from cholesterol-loaded macrophages, 4) to study the effects of alcohol on cholesterol loading in peritoneal macrophages and Kupffer cells and on their ability to synthesize and secrete apo E in response to cholesterol loading, ..
- PINOCYTIC REGULATION IN NORMAL AND TRANSFORMED CELLSJoel Swanson; Fiscal Year: 1990..Earlier work has shown that in thioglycollate-elicited mouse peritoneal macrophages (TMO), only a small percentage of the great quantity of fluid entering by pinocytosis is sent to lysosomes...
- IFN-GAMMA IN EXPERIMENTAL MURINE HISTOPLASMOSISBETTY WU HSIEH; Fiscal Year: 1990..The behavior of the fungus within resident murine peritoneal macrophages cultured in vitro has been studied as a cellular model of the host-parasite interaction in histoplasmosis...
- CELL INTERACTIONS IN ENDOMETRIOSISJOUKO HALME; Fiscal Year: 1990..proposed studies are based on our early observations documenting phenotypic and secretory differences in E peritoneal macrophages as compared to those of normal women (N)...