Genomes and Genes
Summary: Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.
Publications255 found, 100 shown here
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsJ Han
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Science 265:808-11. 1994..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
- A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionH Suzuki
Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
Nature 386:292-6. 1997..In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens...
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall componentsO Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
Immunity 11:443-51. 1999..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
- Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptorTracie DeVries-Seimon
Department of Medicine, Columbia University, New York, NY 10032, USA
J Cell Biol 171:61-73. 2005..These findings have important implications for understanding how the UPR, MAPKs, and the SRA might conspire to cause macrophage death, lesional necrosis, and plaque destabilization in advanced atherosclerotic lesions...
- Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene productK Hoshino
Department of Biochemistry, Hyogo College of Medicine, Japan
J Immunol 162:3749-52. 1999..Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ mice activated NF-kappaB. Taken together, the present study demonstrates that TLR4 is the gene product that regulates LPS response...
- Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayMasahiro Yamamoto
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
Science 301:640-3. 2003..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
- Unresponsiveness of MyD88-deficient mice to endotoxinT Kawai
Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
Immunity 11:115-22. 1999....
- Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophagesReiko Okutsu
Free Radical Project, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
Atherosclerosis 204:405-11. 2009..Thus, we investigated the effect of cilostazol on LDL uptake in mouse peritoneal macrophages (MPM)...
- Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammationHong Wang
Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
Nature 421:384-8. 2003..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
- Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitroSantanu Kar Mahapatra
Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721 102, West Bengal, India
Eur J Pharmacol 623:132-40. 2009..aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine...
- Protective effect of polysaccharide fractions from Radix A. sinensis against tert-butylhydroperoxide induced oxidative injury in murine peritoneal macrophagesXingbin Yang
Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi an 710062, China
J Biochem Mol Biol 40:928-35. 2007..sinensis and their antioxidant activities were evaluated in isolated mouse peritoneal macrophages by pretreatment with APFs before exposure to 0.2 mM tertbutylhydroperoxide (t-BHP)...
- Requirement for transcription factor IRF-1 in NO synthase induction in macrophagesR Kamijo
Department of Microbiology, New York University Medical Center, NY 10016
Science 263:1612-5. 1994..Infection with Mycobacterium bovis (BCG) was more severe in IRF-1-/- mice than in wild-type mice. Thus, IRF-1 is essential for iNOS activation in murine macrophages...
- IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophagesP Puddu
Laboratorie of Immunology, Istituto Superiore di Sanita, Rome, Italy
J Immunol 159:3490-7. 1997We previously reported that resting mouse peritoneal macrophages (PM) constitutively express low levels of IFN-gamma, whose production is consistently enhanced by exogenous IFN-gamma...
- Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction eventsS Bhattacharyya
Department of Microbiology, Bose Institute, Calcutta 700 054, India
Infect Immun 69:1499-507. 2001..donovani induces endogenous secretion of murine IL-10, which in turn facilitates the intracellular survival of the protozoan and orchestrates several immunomodulatory roles via selective impairment of PKC-mediated signal transduction...
- Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing abilityMiriam Rodriguez-Sosa
Department of Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, D F Mexico 14080, Mexico
Infect Immun 70:3656-64. 2002..Here, we have used peritoneal macrophages (F4/80+) recruited at different times after challenge with Taenia crassiceps as APC and tested their ..
- Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulcerationR Langenbach
Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cell 83:483-92. 1995..Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2...
- The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cellsY Xia
Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
J Immunol 162:2281-90. 1999..The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans...
- The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractionsWen Wan Chao
Department of Biochemical Science and Technology, Institute of Microbiology and Biochemistry, National Taiwan University, Taipei 106, Taiwan, ROC
J Ethnopharmacol 122:68-75. 2009..In this study, we employed pNF-kappaB-Luc or pIFN-gamma-Luc and BALB/c mice peritoneal macrophages or splenocytes to investigate both the immune and inflammatory effects of six selected plant species.
- Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-alpha in response to lipopolysaccharide (LPS) in miceRicardo Ambrósio Fock
Experimental Haematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Brazil
Cytokine 40:105-14. 2007..These data lead us to infer that the nutritional state interferes with the activation of macrophages and with the capacity to mount an immune response...
- The expression of cytokine genes in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of the nonobese diabetic miceNik-Soriani Yaacob
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia
J Clin Immunol 24:177-84. 2004..beta, IL-6, and GM-CSF, were increased while the anti-inflammatory cytokine, TGF-beta, decreased in the peritoneal macrophages of nonobese diabetic (NOD) mice. IL-6 expression however decreased when the mice became diabetic...
- Characterization of latent TGF-beta activation by murine peritoneal macrophagesI Nunes
Department of Cell Biology, New York University Medical Center, New York 10016, USA
J Immunol 155:1450-9. 1995..by macrophages was characterized using serum-free cultures of resident and thioglycollate-elicited murine peritoneal macrophages that were either unstimulated or LPS-stimulated in vitro...
- IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophagesPatrizia Puddu
Department of Cell Biology and Neurosciences, Viale Regina Elena 299, 00161 Rome, Italy
J Leukoc Biol 78:686-95. 2005..capable of activating certain macrophage functions, on interferon (IFN)-gamma expression in resting mouse peritoneal macrophages (PM). IL-2 addition to PM from different mouse strains up-modulated IFN-gamma mRNA and protein secretion...
- The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populationsG Grigoriadis
The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria, Australia
EMBO J 15:7099-107. 1996..Stimulated Rel-/- resident peritoneal macrophages produced higher than normal levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), ..
- Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infectionL Soong
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Immunity 4:263-73. 1996..These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite...
- Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophagesSven Wehner
Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, University of Bonn, Bonn, Germany
Am J Physiol Gastrointest Liver Physiol 299:G1187-97. 2010..Purified iSMC and primary peritoneal macrophages (pMacs) were subjected to static or cyclic strain, and gene expression of inducible nitric oxide synthase (..
- Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancerMakoto Matsui
Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
Cancer Sci 101:1670-7. 2010..delivery system (DDS) using oligomannose-coated liposomes (OMLs), which are effectively taken up by mouse peritoneal macrophages to carry anticancer drugs to omental milky spots known as initial metastatic sites in the peritoneal ..
- Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infectionO Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
J Immunol 165:5392-6. 2000..aureus infection, with more enhanced susceptibility in MyD88-deficient mice. Peritoneal macrophages from MyD88-deficient mice did not produce any detectable levels of cytokines in response to S. aureus...
- Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathwayHiroaki Hemmi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nat Immunol 3:196-200. 2002..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
- Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophagesHo Ki Shim
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul 136 705, Korea
Exp Mol Med 41:687-94. 2009..In conclusions, these results indicate that Legionella PAL might activate macrophages via a TLR2-dependent mechanism which thus induce cytokine production and expression of costimulatory and MHC molecules...
- Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activationAjit Sodhi
School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
J Interferon Cytokine Res 22:517-26. 2002..current investigation, we demonstrate activation of the p42/44 MAPK-mediated signal transduction in murine peritoneal macrophages on stimulation with MCP-1 (10-100 ng/ml) in vitro...
- Glycyrrhizin enhances interleukin-12 production in peritoneal macrophagesJ H Dai
Department of Microbiology, Yamanashi Medical University, Yamanashi, Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Immunology 103:235-43. 2001..LPS)-induced IL-12 p40 and IL-12 p70 (heterodimer of p40 and p35) protein production by peritoneal macrophages (PM)...
- Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitroKunal H Bhatt
School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
Mol Immunol 47:861-70. 2010..iNOS) expression and nitric oxide release caused by peptidoglycan from Staphylococcus aureus in mouse peritoneal macrophages. Protein tyrosine kinase inhibitor, genestein and PKCdelta inhibitor, rottlerin attenuated the PGN-induced ..
- Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitroA Vazquez-Torres
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Exp Med 192:227-36. 2000..These findings demonstrate that macrophages kill Salmonella in a dynamic process that changes over time and requires the generation of both reactive oxidative and nitrosative species...
- Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathwayK Stoffels
Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Onderwijs en Navorsing, Herestraat 49, B 3000 Leuven, Belgium
J Steroid Biochem Mol Biol 103:567-71. 2007..We have previously shown that in murine peritoneal macrophages 1alpha-hydroxylase is highly regulated by immune signals such as IFNgamma and LPS...
- Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophagesWei Xu
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 37:1594-9. 2007..We propose that pMPhi have the potential to maintain an anti-inflammatory condition in the peritoneal cavity...
- TIA-1 is a translational silencer that selectively regulates the expression of TNF-alphaM Piecyk
Division of Rheumatology and Immunology, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
EMBO J 19:4154-63. 2000..Mice lacking TIA-1 are hypersensitive to the toxic effects of LPS, indicating that this translational control pathway may regulate the organismal response to microbial stress...
- P2X currents in peritoneal macrophages of wild type and P2X4 -/- miceBert Brône
Gobal Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B2340 Beerse, Belgium
Immunol Lett 113:83-9. 2007In this study the ATP-induced (P2X) currents in isolated peritoneal macrophages of wild type (WT) and P2X(4) knockout (P2X(4)(-/-)) mice were studied by means of whole-cell patch clamp in order to (1) survey the P2X currents of native ..
- FcR gamma chain deletion results in pleiotrophic effector cell defectsT Takai
DeWitt Wallace Research Laboratory, Sloan Kettering Institute, New York, New York 10021
Cell 76:519-29. 1994..These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses...
- Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediatorsM D Lehner
Biochemical Pharmacology, University of Konstanz, Konstanz, Germany
J Immunol 166:5161-7. 2001....
- Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsanJie-Young Song
Laboratory of Immunology, Korea Cancer Center Hospital, Seoul, South Korea
Int Immunopharmacol 2:857-65. 2002..Murine peritoneal macrophages (PM) on in vitro treatment with ginsan isolated from Panax ginseng induced mRNA of cytokines such as tumor ..
- Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteinsOsamu Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
J Immunol 169:10-4. 2002..Taken together, TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides...
- Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophagesChigusa Nakahashi
Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
J Immunol 178:765-70. 2007..amount of the inflammatory cytokines TNF-alpha and IL-6 from DAP12(-/-) as well as wild-type (WT) peritoneal macrophages. We show that MAIR-II associates with not only DAP12 but also FcRgamma chain homodimers in peritoneal ..
- Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3Stephen B Pruett
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
J Immunol 173:2715-24. 2004..Phosphorylation of p38 kinase in peritoneal macrophages (F4/80(+)) was suppressed, as was nuclear translocation of p-c-Jun and p65 in peritoneal cells...
- Upregulation of lipopolysaccharide-induced interleukin-10 by prostaglandin A1 in mouse peritoneal macrophagesHyo Young Kim
Department of Microbiology College of Medicine, Yeungnam University, Daegu, Korea
J Microbiol Biotechnol 18:1170-8. 2008..of action of PGA1 in lipopolysaccharide (LPS)-induced expression of interleukin (IL)-10 mRNA in mouse peritoneal macrophages. 15d-PGJ2 inhibited expression of LPSinduced IL-10, whereas PGA1 increased LPS-induced IL-10 expression...
- TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathwayC D Dumitru
Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
Cell 103:1071-83. 2000..LPS stimulation of peritoneal macrophages from these mice did not activate MEK1, ERK1, and ERK2 but did activate JNK, p38 MAPK, and NF-kappaB...
- Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophagesC A Louis
Department of Surgery, Division of Surgical Research, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
Am J Physiol 276:R237-42. 1999..Moreover, they suggest that a decrease in intracellular L-arginine concentration resulting from its consumption by arginase may be repaired by concurrent increases in L-arginine influx into the cell...
- Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosisBarbara Balestrieri
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:6691-8. 2006..the action of cytosolic phospholipase A2(cPLA2) alpha in regulating eicosanoid biosynthesis by mouse peritoneal macrophages stimulated with zymosan (Satake, Y., Diaz, B. L., Balestrieri, B., Lam, B. K., Kanaoka, Y., Grusby, M. J...
- IL-10 signaling blockade controls murine West Nile virus infectionFengwei Bai
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS Pathog 5:e1000610. 2009..In conclusion, IL-10 signaling plays a negative role in immunity against WNV infection, and blockade of IL-10 signaling by genetic or pharmacologic means helps to control viral infection, suggesting a novel anti-WNV therapeutic strategy...
- Participation of macrophage membrane rafts in Trypanosoma cruzi invasion processE S Barrias
Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, CCS, UFRJ, Ilha do Fundao, 21941 902 Rio de Janeiro, RJ, Brazil
Biochem Biophys Res Commun 363:828-34. 2007..cruzi parasitophorous vacuole. Taken together these data suggest that membrane rafts, including caveolae, are involved in the process of T. cruzi invasion of macrophages...
- Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzoneL P Shornick
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 183:1427-36. 1996..Endotoxin-stimulated peritoneal macrophages from IL-1beta-deficient mice showed normal synthesis and cellular release of IL-1alpha after treatment ..
- SOCS1/JAB is a negative regulator of LPS-induced macrophage activationIchiko Kinjyo
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Immunity 17:583-91. 2002..Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity...
- Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophagesMauricio Alvarez
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
Curr Biol 16:2161-5. 2006....
- Trehalose inhibits inflammatory cytokine production by protecting IkappaB-alpha reduction in mouse peritoneal macrophagesKahoru Taya
Division of Dental Pharmacology, Department of Oral Medical Science, Ohu University School of Dentistry, Koriyama, Fukushima 963 8611, Japan
Arch Oral Biol 54:749-56. 2009The aim of this study was to examine whether trehalose, a disaccharide, could inhibit Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS)-enhanced production of inflammatory cytokines in mouse peritoneal macrophages.
- Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammationElzbieta Kolaczkowska
Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Ingardena 6, 30 060 Krakow, Poland
Arch Immunol Ther Exp (Warsz) 57:459-66. 2009..The aim was thus to verify the expression and activity of the COX isoforms in resident peritoneal mast cells and macrophages during acute peritonitis...
- Advanced glycation end products stimulate tumor necrosis factor-alpha and interleukin-1 beta secretion by peritoneal macrophages in patients on continuous ambulatory peritoneal dialysisGloria Rashid
Department of Nephrology and Hypertension, Sapir Medical Center, Kfar Saba, Israel
Isr Med Assoc J 8:36-9. 2006..AGE-modified 132m has also been shown to enhance chemotaxis and increase tumor necrosis factor-alpha and interleukin-1 beta secretion by circulating and tissue monocytes/macrophages...
- Induction of secretory and tumoricidal activities in peritoneal macrophages activated by an acidic heteropolysaccharide (ARAGAL) from the gum of Anadenanthera colubrina (Angico branco)Mariana Piemonte Moretão
Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531 990 Curitiba, Parana, PR, Brazil
Immunol Lett 93:189-97. 2004..It has been demonstrated that activation of mice peritoneal macrophages both in vivo and in vitro, increases phagocytic ability and anion superoxide production...
- The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophagesViswanathan Saraswathi
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Lipid Res 47:1406-15. 2006..Incubation of mouse peritoneal macrophages with 100 microg/ml VLDL for 6 h led to 2.8- and 3...
- Improvement by several antioxidants of macrophage function in vitroM Del Rio
Department of Animal Physiology, Biology Faculty, Complutense University of Madrid, Spain
Life Sci 63:871-81. 1998..acid (TCA), at different concentrations, on the various steps of the phagocytic process of murine peritoneal macrophages, i.e...
- In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathwayGautam Sethi
School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
Mol Immunol 40:1315-23. 2004In the present study, we report the activation of murine peritoneal macrophages in vitro on irradiation with sublethal dose of UVB (50 mJ/cm(2))...
- Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout backgroundMichael P Vitek
Division of Neurology, Duke University Medical Center, Durham North Carolina 27710, USA
Antioxid Redox Signal 8:893-901. 2006..b>Peritoneal macrophages from double transgenic mice generated nanomolar levels of nitrite in response to inflammatory stimuli, ..
- Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophagesH Sato
Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575 Japan
J Biol Chem 276:10407-12. 2001Amino acid transport in mouse peritoneal macrophages is mediated by several membrane carriers with different substrate specificity and sensitivity to environmental stimuli...
- Enterococcus spp. produces slime and survives in rat peritoneal macrophagesL Baldassarri
Laboratorio di Ultrastrutture, Istituto Superiore di Sanita, Rome, Italy
Med Microbiol Immunol 190:113-20. 2001..Slime-producing E. faecalis were able to survive inside peritoneal macrophages for extended periods compared to slime-negative strains or to slime-positive bacteria grown in conditions ..
- Expression of COX-2 and hsp72 in peritoneal macrophages after an acute ochratoxin A treatment in miceMaria Carmela Ferrante
Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
Life Sci 79:1242-7. 2006..the neutrophil accumulation in parenchymal tissues and the modulation of inflammatory parameters in peritoneal macrophages induced by OTA are involved in its toxicity, and represent early events related to several aspects of OTA ..
- Effect of angiotensin II and losartan on the phagocytic activity of peritoneal macrophages from Balb/C micePaula Belline
Disciplinas de Nefrologia e Medicina Interna, , , , Universidade Estadual de Campinas, 13083-970 Campinas, SP, Brasil
Mem Inst Oswaldo Cruz 99:167-72. 2004..In this study, the effect of AII on the phagocytic activity of mouse peritoneal macrophages was assessed...
- Infection with Mycobacterium avium differentially regulates the expression of iron transport protein mRNA in murine peritoneal macrophagesW Zhong
Department of Microbiology, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
Infect Immun 69:6618-24. 2001..avium differentially regulates mRNA expression of the proteins associated with iron transport in murine peritoneal macrophages. Both Nramp1 and Nramp2 mRNA levels increase following infection, while the expression of transferrin ..
- Recombinant fraction 1 protein of Yersinia pestis activates murine peritoneal macrophages in vitroAjit Sodhi
School of Biotechnology, Banaras Hindu University, Varanasi 221 005, UP, India
Cell Immunol 229:52-61. 2004..In the present investigation it is observed that 10microg/ml of rF1 antigen activated murine peritoneal macrophages in vitro. rF1 induced the production of TNF-alpha, IL-1, IL-6, and NO...
- Anti-inflammatory activity of gumiganghwaltang through the inhibition of nuclear factor-kappa B activation in peritoneal macrophagesSu-Jin Kim
College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemum-Gu, Seoul 130-701, Republic of Korea
Biol Pharm Bull 28:233-7. 2005..In this study, we investigated the anti-inflammatory mechanism of GMGHT in mouse peritoneal macrophages. GMGHT exerted an anti-inflammatory action through inhibiting lipopolysaccaride (LPS)-induced tumor ..
- Bovine dialyzable leukocyte extract modulates the nitric oxide and pro-inflammatory cytokine production in lipopolysaccharide-stimulated murine peritoneal macrophages in vitroMoisés A Franco-Molina
Departamento de Inmunología y Virología, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Nuevo Leon, Mexico
J Med Food 8:20-6. 2005..In this study, to determine whether bDLE modulates NO and pro-inflammatory cytokine production, murine peritoneal macrophages were treated with bDLE (0.05 or 0...
- Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of DouglasK Werner
Department of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
Prostaglandins Leukot Essent Fatty Acids 67:397-404. 2002Cytochrome P450 metabolism of arachidonic acid (AA) was investigated in human peritoneal macrophages which play a central role in chronic pelvic diseases in women (for example in endometriosis)...
- The cytotoxic anti-tumor effect of MTH-68/H, a live attenuated Newcastle disease virus is mediated by the induction of nitric oxide synthesis in rat peritoneal macrophages in vitroAndrás Hrabák
Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, VIII, Puskin u 9, P O Box 260, H 1444 Budapest, Hungary
Cancer Lett 231:279-89. 2006Rat peritoneal macrophages were induced to produce high amounts of nitric oxide (NO) when rats were challenged by MTH68/H, (a live attenuated oncolytic Newcastle disease virus strain)...
- Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cellsR X Faria
Laboratory of Cellular Communication, Department of Immunology, Oswaldo Cruz Institute, FIOCRUZ Oswaldo Cruz Foundation, Av Brazil, 4365, Manguinhos, Rio de Janeiro 21045 900, Brazil
Naunyn Schmiedebergs Arch Pharmacol 382:73-87. 2010..patch clamp technique in conjunction with fluorescent imaging and flow cytometry assays in 2BH4 cells and peritoneal macrophages. Different antagonists were applied to investigate the following pathways: Ca(2+)-calmodulin, ..
- Role of prostaglandin E2 in peptidoglycan mediated iNOS expression in mouse peritoneal macrophages in vitroYogesh Dahiya
School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, India
FEBS Lett 584:4227-32. 2010..In this paper we demonstrate that iNOS expression in mouse peritoneal macrophages in response to bacterial peptidoglycan (PGN) is a secondary effect requiring autocrine signalling of ..
- Kinetics of the phenotype and function of murine peritoneal macrophages following acute inflammationQingli Wu
Laboratory of Immunopharmacology and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Cell Mol Immunol 1:57-62. 2004..A comprehensive kinetics of cytokine production was performed in murine peritoneal macrophages recovered from Balb/c mice at various time during the course of an intraperitoneal injection with ..
- Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitisTomoyuki Wada
Research Laboratories, Senju Pharmaceutical Co, Ltd, Kobe, Japan
Ophthalmic Res 40:54-60. 2008..To determine the anti-inflammatory activity of gatifloxacin in ophthalmic use...
- Phenotypic and functional analysis of murine resident and induced peritoneal macrophagesLyubomyr R Turchyn
Department of Comparative Medicine, Pfizer Global Research and Development, Ann Arbor, MI, USA
Comp Med 57:574-80. 2007..Although approximately 1 million peritoneal macrophages can be obtained from an untreated mouse, more than twice that number can be collected 48 to 72 h after ..
- Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2Shunzhong Bao
Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Biol Chem 282:27100-14. 2007....
- Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosisPei Chin Chuang
Department of Physiology, National Cheng Kung University Medical College, Taiwan, Republic of China
J Pathol 219:232-41. 2009..We report here that the phagocytic ability of macrophages is reduced in peritoneal macrophages isolated from women with endometriosis...
- Fresh mouse peritoneal macrophages have low scavenger receptor activityJ G Kim
Department of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA 30322, USA
J Lipid Res 38:2207-15. 1997b>Peritoneal macrophages are easily isolated by lavage, suggesting that they are either nonadherent or weakly adherent in situ. Cultured macrophages express class A scavenger receptors (SCR), which mediate Ca2+-independent adhesion in vitro...
- Dietary glutamine supplementation increases the activity of peritoneal macrophages and hemopoiesis in early-weaned mice inoculated with Mycobacterium bovis bacillus Calmette-GuérinMarcelo Macedo Rogero
Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
J Nutr 138:1343-8. 2008..The purpose of this study was to investigate the effect of glutamine supplementation on the function of peritoneal macrophages and on hemopoiesis in early-weaned mice inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG)..
- In vitro immunomodulatory effects of fractions obtained from aqueous extracts of Larrea divaricata Cav (Jarilla) on mouse peritoneal macrophagesRenzo F Martino
Microbiology Section, Department of Biochemistry and Biological Science, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina
Immunopharmacol Immunotoxicol 32:125-32. 2010..Larrea divaricata Cav. (Zygophyllaceae) is a plant widely used in Argentina...
- Survival of Enterococcus faecalis in mouse peritoneal macrophagesC R Gentry-Weeks
Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
Infect Immun 67:2160-5. 1999Enterococcus faecalis was tested for the ability to persist in mouse peritoneal macrophages in two separate studies. In the first study, the intracellular survival of serum-passaged E...
- Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis modelKenneth A Howard
Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
Mol Ther 17:162-8. 2009..anti-TNF-alpha Dicer-substrate siRNA (DsiRNA) mediated TNF-alpha knockdown (approximately 66%) in primary peritoneal macrophages in vitro...
- The change in leukotrienes and lipoxins in activated mouse peritoneal macrophagesL Calorini
Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni 50, 50134, Florence, Italy
Biochim Biophys Acta 1484:87-92. 2000..We used a system of murine peritoneal macrophages at different states of activation consisting in resident macrophages and FCS-, thioglycollate- or ..
- Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulationT Nakajima
Division of Environmental Health Research, Osaka Prefectural Institute of Public Health, 69 3, 1 chome, 537 0025, Osaka, Japan
Int J Biochem Cell Biol 32:779-87. 2000..In the present study, we investigated how chrysotile-stimulated macrophages generate superoxide using murine peritoneal macrophages, with special attention to the modulatory role of phospholipase A(2) (PLA(2))...
- Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetateStefan Jung
, , Germany
J Neuroimmunol 148:63-73. 2004..Using freshly isolated resident peritoneal macrophages from naive Lewis rats, it is shown that GLAT profoundly modulates cytokine secretion of the cells...
- PEGylation of anti-sialoadhesin monoclonal antibodies enhances their inhibitory potencies without impairing endocytosis in mouse peritoneal macrophagesJulie Ducreux
Department of Pharmaceutical Technology, School of Pharmacy, de Duve Institute, Universite Catholique de Louvain, 1200 Brussels, Belgium
Bioconjug Chem 20:295-303. 2009..the effect of anti-Sn SER-4 and 3D6 mAbs PEGylation on their inhibition of cell adhesion in mouse peritoneal macrophages. We also examined whether Sn-mediated PEGylation could affect plasma membrane functions of macrophages as ..
- Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophagesA de Moreno de LeBlanc
Centro de Referencia para Lactobacilos CERELA CONICET, Chacabuco 145, Tucuman, Argentina T4000ILC
Immunobiology 213:97-108. 2008..of commercial fermented milk containing probiotic bacteria in the mucosal immune response and peritoneal macrophages was analyzed. BALB/c mice were fed with fermented milk for 98 consecutive days...
- Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesisRomeo Ricci
Cardiovascular Research, Institute of Physiology, and Division of Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
Science 306:1558-61. 2004..Thus, JNK2-dependent phosphorylation of SR-A promotes uptake of lipids in macrophages, thereby regulating foam cell formation, a critical step in atherogenesis...
- Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophagesLeanne Stokes
Department of Biomedical Science, University of Sheffield, Addison Building Western Bank, Sheffield, United Kingdom
J Immunol 179:6016-23. 2007..Similar results were obtained from rat peritoneal macrophages. We investigated likely downstream signaling cascades that may be involved, specifically the canonical G(q)..
- Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitusMatthew E Hartman
Department of Animal Sciences, University of Illinois at Urbana Champaign, 506 South Mathews, Urbana, IL 61801, USA
J Biol Chem 279:28045-50. 2004..Resident peritoneal macrophages (PerMPhis) from diabetic (db/db) mice showed a 44% reduction in IRS-2-associated PI3-kinase activity ..
- Cellular signaling during the macrophage invasion by Trypanosoma cruziMauricio Vieira
, , , Universidade Federal do Rio de Janeiro, RJ, Brazil
Histochem Cell Biol 118:491-500. 2002..These achievements support the model for a phagocytic-like actin-dependent invasion mechanism for T. cruzi trypomastigotes into macrophages...
- A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosisDana G Mordue
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
J Leukoc Biol 74:1015-25. 2003..Our findings suggest that activated CD68+/Gr-1+ macrophages contribute to parasite control during infection by directly inhibiting parasite replication and through production of T helper cell type I cytokines...
- Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathwayBertrand Calippe
Institut National de la Santé et de la Recherche Médicale U858, Institut de Medecine Moleculaire de Rangueil, IFR31, Toulouse, France
J Immunol 180:7980-8. 2008..In the present study, we confirm that in vitro exposure of mouse peritoneal macrophages to E2 enhanced Akt phosphorylation and slightly decreased LPS-induced cytokine production...
- Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckiiKarla Simone S Fernandes
Department of Pharmacology, School of Medicine Ribeirao Preto, Unviersity of São Paulo, Sao Paulo, Brazil
Immunology 123:469-79. 2008..schenckii by macrophages, the activation of NO system in vivo contributes to the immunosuppression and cytokine balance during early phases of infection with S. schenckii...
- Prostaglandin E2-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus miceByeong Suk Chae
College of Pharmacy, Woosuk University, Wanju, Jeonbuk, Korea
Arch Pharm Res 31:503-10. 2008..Our results showed that levels of serum and BAL PGE(2) and LPS-stimulated production of PGE(2) by peritoneal macrophages were remarkably increased in pristane-induced lupus mice compared to healthy controls...
- Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophagesKiyoshi Wakahara
NetForce Co, Ltd, Aichi, Japan
J Infect Dis 191:930-8. 2005..Lipopolysaccharide (LPS) is the primary mediator of gram-negative sepsis; it induces the production of macrophage-derived cytokines. It has been shown that bikunin, a Kunitz-type protease inhibitor, inhibits LPS-induced cytokine expression...
- The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophagesXianhua Cao
Biophysics Program, Ohio State University, Columbus, OH 43210, USA
J Immunol 172:4851-7. 2004..We demonstrate that in ex vivo murine peritoneal macrophages that are deficient in PTEN expression, Fc gamma R-induced Akt and extracellular signal-regulated kinase ..
- Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitationLoren S Scuro
Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, 13083 970, Brazil
BMC Biochem 5:5. 2004....
- Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophagesNitza Lahat
Immunology Research Unit, Carmel Medical Center, Haifa, Israel
Am J Physiol Cell Physiol 295:C2-12. 2008..However, we show that in primary mouse peritoneal macrophages and in three mouse peritoneal macrophage cell lines (RAW 264.7, J774A.1, and PMJ-2R), hypoxia (O(2) < 0...
- Rutin inhibits nitric oxide and tumor necrosis factor-alpha production in lipopolysaccharide and concanavalin-a stimulated macrophagesC Guruvayoorappan
Amala Cancer Research Centre, Thrissur, India
Drug Metabol Drug Interact 22:263-78. 2007..75 microM) to the normal level (16.13 microM) at a concentration of 5 microg/ml. In vitro L929 bioassay also showed inhibition of TNF-alpha production by rutin treatment...
- Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophagesOliver Soehnlein
Department of Physiology and Pharmacology and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
J Clin Invest 118:3491-502. 2008..Thus, we attribute what may be a novel role for PMN granule proteins in regulating the immune response to bacterial infections...
- ROLE OF EICOSANOIDS IN SHOCKJames Cook; Fiscal Year: 1990..in arachidonic acid content; its uptake into and release from phospholipids and phospholipase activity of peritoneal macrophages from rates following endotoxemia and the induction of endotoxin tolerance...
- EFFECT OF MARIJUANA ON MACROPHAGE ANTIGEN PRESENTATIONGuy Cabral; Fiscal Year: 1993..The (B6C3)F1 mouse will be employed for in vivo drug exposure and as a source of peritoneal macrophages. The macrophage line P388D1 will be used for in vitro experiments...
- MYELOPOIETIC STIMULATION FOLLOWING BURN INJURYRichard Gamelli; Fiscal Year: 2007..The responses of PDMo are similar to the responses of peritoneal macrophages (PMo) emphasizing the relevance of PDMo to the pathobiology of injury and sepsis...
- Group V sPla2 in Inflammation and Innate ImmunityBarbara Balestrieri; Fiscal Year: 2007..Using group V secretory PLA2 (sPLA2)-null mouse peritoneal macrophages we showed that group V sPLA2 amplifies the action of cytosolic PLA2alpha (cPLA2 alpha) in regulating ..
- Campylobacter jejuni and Reactive Nitrogen SpeciesNicole Iovine; Fiscal Year: 2007..To assess the biological significance of these genes, we will measure the ability of peritoneal macrophages from iNOS-null mice to kill RNS-hypersusceptible strains versus the wild-type...
- ROLE OF EICOSANOIDS IN SHOCKJames Cook; Fiscal Year: 1993..specific G proteins transducing lipid A (the toxic moiety of LPS) stimulation of eicosanoids in rat peritoneal macrophages. The mechanism(s) of lipid A induced increases in macrophage membrane GTPase and of reduced GTPase ..
- ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTIONKATHY TIMMS; Fiscal Year: 2006..To test this hypothesis, peritoneal macrophages, and endometriotic lesions when present, will be collected from women without and with endometriosis...
- Role of Ion Channel in Mononuclear Phagocyte ActivationDeborah Nelson; Fiscal Year: 2009..We will compare the phagocytic and secretory activities of alveolar and peritoneal macrophages as well as neutrophils and the anion channels that are involved in the regulation of these activities...
- INTERACTION OF ENTEROCOCCUS FAECALIS WITH MACROPHAGESClaudia Gentry Weeks; Fiscal Year: 2003..faecalis isolates are able to survive in mouse peritoneal macrophages, J774A.1 macrophage-like cells, and murine bone marrow derived macrophages for an extended period of time...
- Retinoid effects on inflammation and cell growth associated with endometriosisNeil Sidell; Fiscal Year: 2010..Aim 2 will determine the physiologic implications of retinoid action on CD36 as relates to peritoneal macrophages from women with endometriosis...
- Retinoid effects on inflammation and cell growth associated with endometriosisNeil Sidell; Fiscal Year: 2010..Aim 2 will determine the physiologic implications of retinoid action on CD36 as relates to peritoneal macrophages from women with endometriosis...
- Feasibility of Hemin-Based Therapy in Experimental Acute PancreatitisM Omary; Fiscal Year: 2006..This aim also entails exposing peritoneal macrophages to siRNA directed towards HO-1 in order to test if HO-1 activation is important for macrophage protection ..
- INFLAMMATORY NEUROLOGICAL DISEASESIain Campbell; Fiscal Year: 2001..of astrocytes and microglial cells (both of which he has demonstrated to make IL12 on LPS stimulation) and peritoneal macrophages. He will define the time course of IL12 induction by LPS, attempt to define the mechanism of secretion ..
- CD14 AND THE IMMUNOPATHOGENESIS OF CHRONIC LYME DISEASETIMOTHY SELLATI; Fiscal Year: 2007..Furthermore, peritoneal macrophages from CD14-deficient mice produced more proinflammatory TNF-alpha and less anti-inflammatory IL-10 than ..
- HIV PROTEASE INHIBITORS AND ATHEROSCLEROSISEric Smart; Fiscal Year: 2006..Our preliminary data demonstrate that peritoneal macrophages isolated from LDL receptor null mice given the HIV protease inhibitors, amprenavir, indinavir, or ..