foam cells

Summary

Summary: Lipid-laden macrophages originating from monocytes or from smooth muscle cells.

Top Publications

  1. ncbi Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 280:2352-60. 2005
  2. ncbi Monocyte recruitment and foam cell formation in atherosclerosis
    Yuri V Bobryshev
    Surgical Professorial Unit, St Vincent s Hospital, 234 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Micron 37:208-22. 2006
  3. pmc Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
    Mireille Ouimet
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Cell Metab 13:655-67. 2011
  4. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
  5. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
  6. ncbi Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Prog Lipid Res 50:331-47. 2011
  7. pmc Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake
    Soo Ho Choi
    Department of Medicine, University of California at San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Circ Res 104:1355-63. 2009
  8. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
  9. pmc Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice
    Eugene Trogan
    Marc and Ruti Bell Vascular Biology Program, Leon H Charney Division of Cardiology Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:3781-6. 2006
  10. pmc The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:5827-34. 2010

Detail Information

Publications297 found, 100 shown here

  1. ncbi Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1422, USA
    J Biol Chem 280:2352-60. 2005
    ..LDL by PMA-activated human monocytederived macrophages converted these macrophages into cholesterol-enriched foam cells (Kruth, H. S., Huang, W., Ishii, I., and Zhang, W. Y. (2002) J. Biol. Chem. 277, 34573-34580)...
  2. ncbi Monocyte recruitment and foam cell formation in atherosclerosis
    Yuri V Bobryshev
    Surgical Professorial Unit, St Vincent s Hospital, 234 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Micron 37:208-22. 2006
    ..In the subendothelial space enriched with atherogenic lipoproteins, most macrophages transform into foam cells. Foam cells aggregate to form the atheromatous core and as this process progresses, the atheromatous centres of ..
  3. pmc Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
    Mireille Ouimet
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Cell Metab 13:655-67. 2011
    The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis...
  4. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
    The formation of foam cells from macrophages in the arterial wall is characterized by dramatic changes in lipid metabolism, including increased expression of scavenger receptors and the uptake of oxidized low-density lipoprotein (oxLDL)...
  5. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
    ..These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence...
  6. ncbi Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Prog Lipid Res 50:331-47. 2011
    ..to plaque development by internalizing native and modified lipoproteins to convert them into cholesterol-rich foam cells. Foam cells not only help to bridge the innate and adaptive immune response to atherosclerosis but also ..
  7. pmc Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake
    Soo Ho Choi
    Department of Medicine, University of California at San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Circ Res 104:1355-63. 2009
    ....
  8. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
    Accumulation of macrophage foam cells in atherosclerotic blood vessel intima is a critical component of atherogenesis mediated by scavenger receptor-dependent internalization of oxidized LDL...
  9. pmc Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice
    Eugene Trogan
    Marc and Ruti Bell Vascular Biology Program, Leon H Charney Division of Cardiology Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:3781-6. 2006
    ..In previous studies of regression in mice, the rapid loss of plaque foam cells was explained by emigration to lymph nodes, a process reminiscent of dendritic cells...
  10. pmc The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 184:5827-34. 2010
    ..We show, for the first time, a novel proatherogenic role for both TL1A and DR3 that implicates this pathway as a target for the therapeutic intervention of atherosclerosis...
  11. ncbi Macrophage differentiation to foam cells
    Pavel Shashkin
    University of Virginia Health System, Cardiovascular Research Center, MR5 Bldg Rm 1013, P O Box 801 394, Charlottesville, VA 22908, USA
    Curr Pharm Des 11:3061-72. 2005
    ..Selective inhibitors of lipoxygenases and leukotriene receptors could be useful in the treatment of atherosclerosis by preventing or reducing foam cell formation...
  12. pmc Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells
    Radmila Feldmann
    Max Planck Institute for Molecular Genetics, Ihnestraße 63 73, 14195 Berlin, Germany
    Nucleic Acids Res 41:3518-31. 2013
    ..Lipid-loaded macrophages, termed foam cells, are important during the early development of atherosclerotic plaques...
  13. ncbi Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha
    Kuo Yun Lu
    Department of Physiology, National Yang Ming University, Taipei 112, Taiwan
    Circulation 121:1828-37. 2010
    ..However, the role of erythropoietin and its underlying mechanism in macrophage foam cell formation are poorly understood...
  14. ncbi IL-33 reduces macrophage foam cell formation
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    J Immunol 185:1222-9. 2010
    ..E(-/-) mice fed on a high fat diet, IL-33 treatment significantly reduced the accumulation of macrophage-derived foam cells in atherosclerotic plaques...
  15. pmc Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
    ..of aortic sinus lesions by electron microscopy and immunohistochemistry showed abundant macrophage foam cells, indicating that lipid uptake by intimal macrophages occurs in the absence of CD36 or SR-A...
  16. ncbi Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro
    Yang Yuan
    Dept of Endocrinology, Zhongda Hospital, Southeast University, No 87 Dingjiaqiao, Nanjing, Jiangsu Province 21009, P R China
    Am J Physiol Renal Physiol 301:F236-43. 2011
    ..These data imply that inhibitors of Golgi-processing enzymes might have a potential renoprotective role in prevention of mesangial foam cell formation...
  17. ncbi Macrophage scavenger receptors and foam cell formation
    W J de Villiers
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536 0084, USA
    J Leukoc Biol 66:740-6. 1999
    ..Caveolae are initial acceptor sites for cholesteryl esters and these findings indicate a possible role for caveolae and SR-BI in Mphi-selective lipid uptake and in regulating Mphi cholesterol flux in the vascular wall...
  18. ncbi Adiponectin increases macrophages cholesterol efflux and suppresses foam cell formation in patients with type 2 diabetes mellitus
    Min Wang
    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat Sen University Northern Campus, Guangzhou, Guangdong Province 510080, China
    Atherosclerosis 229:62-70. 2013
    ..To determine the mechanism through which adiponectin deficiency mediates accelerated cardiovascular disease in patients with diabetes, we investigated the effects of adiponectin on macrophage cholesterol deposition...
  19. pmc TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2
    Daryn R Michael
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Biochim Biophys Acta 1822:1608-16. 2012
    ..of key genes implicated in the uptake of modified low density lipoproteins and the efflux of cholesterol from foam cells was Smad-dependent...
  20. ncbi Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis
    Jing Feng Zhao
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Mol Nutr Food Res 56:691-701. 2012
    ..In this study, we examined the effect of curcumin on lipid accumulation and the underlying molecular mechanisms in macrophages and apolipoprotein E-deficient (apoE⁻/⁻) mice...
  21. ncbi Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice
    Michishige Terasaki
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Metabolism 61:974-7. 2012
    ..Foam cell formation was suppressed by 40% in the exudate peritoneal macrophages obtained from the PKF-treated mice. The DPP-4 inhibitor prevents the development of atherosclerotic lesions by suppressing macrophage foam cell formation...
  22. ncbi Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Circulation 117:638-48. 2008
    ....
  23. pmc Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice
    Edward Thorp
    Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 28:1421-8. 2008
    ..Herein we test the hypothesis that the Mertk(KD) mutation would result in increased accumulation of apoptotic cells and promote necrotic core expansion in a mouse model of advanced atherosclerosis...
  24. pmc Toll-like receptor-4 and lipoprotein accumulation in macrophages
    Yury I Miller
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Trends Cardiovasc Med 19:227-32. 2009
    ..A novel hypercholesterolemic zebrafish model of early stages of atherosclerosis was used to demonstrate that the TLR4 deficiency significantly reduces the in vivo rate of macrophage lipid accumulation in vascular lesions...
  25. ncbi EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1
    Jin Yi Tsai
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 88:415-23. 2010
    Accumulation of foam cells in the intima is a hallmark of early-stage atherosclerotic lesions...
  26. ncbi The role of hypoxia in atherosclerosis
    Lillemor Mattsson Hulten
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, University of Gothenburg, Sweden
    Curr Opin Lipidol 20:409-14. 2009
    ..Here we summarize the role of hypoxia in the development of advanced atherosclerotic lesions by promoting lipid accumulation, inflammation, ATP depletion, and angiogenesis...
  27. pmc Human immunodeficiency virus impairs reverse cholesterol transport from macrophages
    Zahedi Mujawar
    The George Washington University, Washington, District of Columbia, USA
    PLoS Biol 4:e365. 2006
    ..HIV-infected and Nef-transfected macrophages accumulated substantial amounts of lipids, thus resembling foam cells. The contribution of HIV-infected macrophages to the pathogenesis of atherosclerosis was supported by the ..
  28. ncbi Macrophage foam cell formation with native low density lipoprotein
    Howard S Kruth
    Section of Experimental Atherosclerosis, NHLBI National Institutes of Health, Bldg 10 Rm 5N 113, 10 Center Drive, MSC 1422, Bethesda, MD 20892, USA
    J Biol Chem 277:34573-80. 2002
    This investigation has elucidated a mechanism for development of macrophage foam cells when macrophages are incubated with native low density lipoprotein (LDL)...
  29. ncbi Cellular lipid metabolism and the role of lipids in progressive renal disease
    Christine K Abrass
    Department of Medicine, University of Washington School of Medicine, Seattle, Wash 98108, USA
    Am J Nephrol 24:46-53. 2004
    ..There is a special emphasis on foam cells in the kidney and on lipid-mediated changes in intrinsic kidney cells that lead to glomerulosclerosis and ..
  30. ncbi Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis
    Yuan Yuan
    Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Protein Cell 3:173-81. 2012
    ..The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis...
  31. ncbi Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice
    Kumaravelu Jagavelu
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 01, 30625 Hannover, Germany
    Circ Res 101:1104-12. 2007
    ..Therefore, MK2 might represent an attractive novel target for the treatment of atherosclerotic cardiovascular disease...
  32. pmc Foamy macrophages and the progression of the human tuberculosis granuloma
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Nat Immunol 10:943-8. 2009
    ..The foamy macrophage seems to be a key participant in both sustaining persistent bacteria and contributing to the tissue pathology that leads to cavitation and the release of infectious bacilli...
  33. ncbi Induction of dendritic cell-like phenotype in macrophages during foam cell formation
    Hyung Jun Cho
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908, USA
    Physiol Genomics 29:149-60. 2007
    ..blood mononuclear cells, monocytes, and macrophages treated with CXCL1 (GRO-alpha) or CCL2 (MCP-1), as well as foam cells induced by native LDL, mmLDL, or oxLDL using 22 Affymetrix gene chips...
  34. ncbi Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation
    E Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Circulation 113:98-107. 2006
    ....
  35. pmc Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis
    Antoni Paul
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circ Res 102:1492-501. 2008
    b>Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell formation per se protects against atherosclerosis or fuels it...
  36. ncbi Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 103:1057-63. 2001
    ..The present study investigated the effects of adiponectin on lipid accumulation in human monocyte-derived macrophages...
  37. ncbi Genomics of foam cells and nonfoamy macrophages from rabbits identifies arginase-I as a differential regulator of nitric oxide production
    Anita C Thomas
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom
    Arterioscler Thromb Vasc Biol 27:571-7. 2007
    Conversion of macrophages to foam cells is a critical step in the initiation and progression of atherosclerosis...
  38. ncbi Interferon gamma: a master regulator of atherosclerosis
    James E McLaren
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Cytokine Growth Factor Rev 20:125-35. 2009
    ..This review will focus on evaluating the contribution of IFN-gamma to atherosclerosis and, in particular, how it regulates immune responses to the disease...
  39. ncbi Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Circ Res 102:113-20. 2008
    The concept that macrophages can become foam cells as a result of a disturbed balance between the uptake of cholesterol from lipoproteins and cholesterol efflux is generally accepted...
  40. ncbi The macrophage foam cell as a target for therapeutic intervention
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 8:1235-42. 2002
  41. ncbi Hemin modulates cytokine expressions in macrophage-derived foam cells via heme oxygenase-1 induction
    Jian Li Ma
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    J Pharmacol Sci 103:261-6. 2007
    Lipid-laden foam cells were considered to be targets for therapeutic intervention in atherosclerosis. Several studies proposed new approaches to alter both lipid accumulation and inflammatory responses in macrophages...
  42. ncbi Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells
    Chun li Mei
    Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, Wuhan, Hubei Province 430022, China
    Cell Biol Int 31:1456-61. 2007
    ..However, the effects of inflammatory cytokines on ABCA1 expression and cholesterol accumulation in foam cells are little known...
  43. ncbi Macrophage-derived foam cells in atherosclerosis: lessons from murine models and implications for therapy
    Nancy R Webb
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Drug Targets 8:1249-63. 2007
    Macrophage-derived foam cells play integral roles in all stages of atherosclerosis...
  44. ncbi Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells
    Leena Lindstedt
    Wihuri Research Institute, Helsinki, Finland
    Biochem Biophys Res Commun 312:1019-24. 2003
    ..that cathepsin-secreting cells induce rapid depletion of lipid-poor (prebeta-HDL) and lipid-free apoA-I and inhibit cellular cholesterol efflux, so tending to promote the formation and maintenance of foam cells in atherosclerotic lesions.
  45. pmc Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, NC10, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Trans Am Clin Climatol Assoc 121:206-20. 2010
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development in athero-thrombotic disorders...
  46. ncbi Expression of the LXRalpha protein in human atherosclerotic lesions
    Yuichiro Watanabe
    Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:622-7. 2005
    ..To clarify its role in atherogenesis, we established a monoclonal antibody recognizing native human LXRalpha protein and studied the expression pattern in human atherosclerotic lesions...
  47. ncbi Toll-like receptor 4 is up-regulated by mTOR activation during THP-1 macrophage foam cells formation
    Miao Yu
    Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Acta Biochim Biophys Sin (Shanghai) 43:940-7. 2011
    Macrophage foam cells formation is the most important process in atherosclerotic plaque formation and development...
  48. ncbi Interleukin-18 and interleukin-12 together downregulate ATP-binding cassette transporter A1 expression through the interleukin-18R/nuclear factor-κB signaling pathway in THP-1 macrophage-derived foam cells
    Xiao hua Yu
    Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, Hunan, China
    Circ J 76:1780-91. 2012
    ..The aim of the present study was to investigate the effect of IL-18 and/or IL-12 on ABCA1 expression...
  49. ncbi Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells
    Jin Jiang
    Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang 421001, P R China
    Int J Mol Med 29:946-56. 2012
    ..In the study presented here, we found that exposure of macrophage foam cells to TNF-α results in a downregulation of ABCA1 and a decrease in cholesterol efflux to apoA1, which ..
  50. ncbi Cross-talk between TLR4-MyD88-NF-κB and SCAP-SREBP2 pathways mediates macrophage foam cell formation
    Lung Chih Li
    John Moorhead Renal Research Laboratory, Centre for Nephrology, University College London Medical School, Royal Free Campus, London, United Kingdom
    Am J Physiol Heart Circ Physiol 304:H874-84. 2013
    ....
  51. ncbi Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells
    Stefania Gessi
    Chair of Pharmacology, Faculty of Medicine, University of Ferrara, Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 30:90-7. 2010
    ..As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs...
  52. pmc Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles
    Howard S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 1422, USA
    Curr Opin Lipidol 22:386-93. 2011
    ..The purpose of this review is to discuss recent findings showing that native unmodified LDL can induce massive macrophage cholesterol accumulation mimicking macrophage foam cell formation that occurs within atherosclerotic plaques...
  53. ncbi Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation
    Yuchang Fu
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Blood Cells Mol Dis 32:182-90. 2004
    ..of GLUT 1-5 mRNA and protein in isolated human lymphocytes and monocytes and in human THP-1 macrophages and foam cells. Lymphocytes expressed GLUT 1 and GLUT 3 proteins, and cellular levels of both isoforms were augmented 3...
  54. ncbi Foam cells in atherosclerosis
    Xiao hua Yu
    Life Science Research Center, University of South China, Hengyang, Hunan 421001, China
    Clin Chim Acta 424:245-52. 2013
    ..Macrophage foam cells play a critical role in the occurrence and development of atherosclerosis...
  55. pmc Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL
    Joshua J Anzinger
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 53:34-42. 2012
    ..However, it has not been determined whether murine GM-CSF-differentiated macrophages take up LDL to become foam cells. GM-CSF-differentiated macrophages from LDL receptor-null mice were incubated with LDL, resulting in massive ..
  56. ncbi Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation
    Sima Allahverdian
    Department of Medicine, UBC James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Room 166, Burrard Building, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Cardiovasc Res 95:165-72. 2012
    ..An increased understanding of the contribution of these cell types to lesion development will help to delineate their relative importance in atherogenesis and as potential therapeutic targets...
  57. ncbi Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells
    Kenneth W Howell
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, USA
    J Surg Res 171:e27-31. 2011
    Macrophage foam cells are central in the development of atherosclerosis, but the mechanism of foam cell formation is unclear. Toll-like receptor 4 (TLR4) signaling is known to participate in the pathogenesis of atherosclerosis...
  58. ncbi Identification of lipid droplet-associated proteins in the formation of macrophage-derived foam cells using microarrays
    Hang Li
    State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi an, P R China
    Int J Mol Med 26:231-9. 2010
    A large number of macrophage-derived foam cells stores excessive neutral lipids in intracellular droplets, and plays a major role during the development of atherosclerosis...
  59. ncbi Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography
    Eduardo J Folco
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 58:603-14. 2011
    ....
  60. ncbi Possible involvement of protein kinase C in the induction of adipose differentiation-related protein by Sterol ester in RAW 264.7 macrophages
    J S Chen
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan 100
    J Cell Biochem 83:187-99. 2001
    The accumulation of lipid droplets in macrophages contributes to the formation of foam cells, an early event in atherosclerosis. It is, therefore, important to elucidate the mechanisms by which lipid droplets accumulate and are utilized...
  61. ncbi Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    Gang Xu
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Circ Res 105:500-10. 2009
    ..proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary atherosclerotic lesions...
  62. ncbi Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon
    Adriana R Silva
    Laboratório de Inflamação, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1791:1066-75. 2009
    ..In conclusion, oxLDL-driven foam cells are enriched with leukotriene-synthesizing lipid bodies--specialized organelles whose biogenic process is ..
  63. pmc A macrophage sterol-responsive network linked to atherogenesis
    Lev Becker
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Cell Metab 11:125-35. 2010
    ..These observations identify a highly integrated network of proteins whose expression is influenced by environmental, genetic, and pharmacological factors implicated in atherogenesis...
  64. ncbi The role of the stress-related anti-inflammatory hormones ACTH and cortisol in atherosclerosis
    Panayotis Fantidis
    Unidad de Angiología y Cirugía Vascular, Hospital San Pedro de Alcántara Complejo Hospitalario de Cáceres, Caceres, Comunidad Autónoma de Extremadura, Madrid, Spain
    Curr Vasc Pharmacol 8:517-25. 2010
    ..the recruitment of circulating monocytes to the artery wall and their differentiation into macrophages- foam cells, by controlling the expression of pro- and anti-inflammatory interleukins...
  65. pmc Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties
    Valentin P Yakubenko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Blood 107:1643-50. 2006
    ..recently discovered member of the beta2 subfamily of integrin adhesion receptors, is up-regulated on macrophage foam cells. Although other members of the subfamily have been subjects of extensive research, the recognition specificity ..
  66. ncbi Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions
    Ying Zhao
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Leiden, The Netherlands
    Curr Opin Lipidol 21:441-53. 2010
    ..This review focuses on the understanding of the different cholesterol efflux pathways and physiological acceptors involved, and their regulation in atherosclerotic lesions...
  67. ncbi Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages
    G Chinetti-Gbaguidi
    Institut Pasteur de Lille, Lille F 59019, France
    Biochim Biophys Acta 1791:486-93. 2009
    ..in the sub-endothelial space, monocytes differentiate into macrophages, accumulate lipids thus forming foam cells and secrete pro-inflammatory and matrix-degrading factors, thus playing a role in plaque development, ..
  68. pmc Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice
    Mie Higashimori
    Tufts Medical Center, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 31:50-7. 2011
    ....
  69. ncbi Local elastic modulus of atherosclerotic lesions of rabbit thoracic aortas measured by pipette aspiration method
    Takeo Matsumoto
    Biomechanics Laboratory, Graduate School of Mechanical Engineering, Tohoku University, Aoba yama 01, Sendai 980 8579, Japan
    Physiol Meas 23:635-48. 2002
    ..Histological observation revealed that the initial soft lesion was mainly composed of foam cells, and the stiffening accompanied first the appearance of smooth muscle cells in the top layer of the hyperplastic ..
  70. pmc TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
    Shaozhen Xie
    George Whipple Lab for Cancer Research, Department of Pathology, and Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:13353-8. 2009
    ....
  71. ncbi Macrophage foam cells and atherosclerosis
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Front Biosci 6:D429-55. 2001
    ..Some cytokines, hormones, and pharmacologic agents show potential to modulate these processes and may be useful in directing macrophage function in atherosclerotic lesions towards beneficial rather than harmful effects...
  72. ncbi Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles
    Riikka Vikstedt
    National Public Health Institute, Department of Molecular Medicine, Biomedicum, P O Box 104, FI 00251 Helsinki, Finland
    Biochemistry 46:11979-86. 2007
    Phospholipid transfer protein (PLTP) is expressed by macrophage-derived foam cells in human atherosclerotic lesions, suggesting a regulatory role for PLTP in cellular cholesterol homeostasis...
  73. pmc Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice
    Jennifer J Manning-Tobin
    Lipid Metabolism Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 29:19-26. 2009
    ..To test the impact of deleting these receptors, we generated Apoe(-/-) mice lacking both SR-A and CD36 and fed them a Western diet for 12 weeks...
  74. ncbi Lysosomal enzymes are released from cultured human macrophages, hydrolyze LDL in vitro, and are present extracellularly in human atherosclerotic lesions
    Jukka K Hakala
    Wihuri Research Institute, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 23:1430-6. 2003
    ..However, little is known about the hydrolytic enzymes in the arterial intima that induce fusion of LDL particles and so produce lipid droplets or that induce foam cell formation...
  75. ncbi Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice
    Masaharu Nagashima
    Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Atherosclerosis 212:70-7. 2010
    ..Thus we investigated the effects of salusin-alpha and -beta on atherosclerotic plaque formation in vivo in apolipoprotein E-deficient (ApoE-/-) mice...
  76. ncbi Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    FASEB J 20:2559-61. 2006
    ..whether platelets are involved in progenitor cell recruitment and differentiation into endothelial cells and foam cells, we examined the interactions of platelets and CD34+ progenitor cells...
  77. pmc A simple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells
    Peggy Robinet
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Lipid Res 51:3364-9. 2010
    ..In conclusion, we describe a sensitive, simple, and high-throughput enzymatic method to quantify cholesterol in complex matrices such as cells...
  78. ncbi Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis
    Dorothea Siegel-Axel
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Cardiovasc Res 78:8-17. 2008
    ..New data about platelet-mediated lipoprotein transport and consequent foam cell formation, however, provide proof of how platelets might contribute to atheromatous lesion formation...
  79. pmc Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions
    Chiara Buono
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute NHLBI, NIH, Bethesda, Maryland 20892 1422, USA
    J Clin Invest 119:1373-81. 2009
    ..displayed massive accumulation of the nanoparticles within CD68+ macrophages, including lipid-containing foam cells, in atherosclerotic lesions in the aortic arch...
  80. ncbi Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation
    Qiang Ye
    Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
    Inflamm Res 58:809-18. 2009
    ....
  81. ncbi Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors
    David R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Lipid Res 46:11-20. 2005
    ..We critically evaluate the potential of scavenger receptors and their ligands as targets for therapeutic intervention in human disease...
  82. ncbi Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice
    Robert J Aiello
    Department of Cardiovascular and Metabolic Disease, Pfizer Global Research and Development, Groton, Conn 06340, USA
    Arterioscler Thromb Vasc Biol 22:443-9. 2002
    ....
  83. pmc Low tissue inhibitor of metalloproteinases 3 and high matrix metalloproteinase 14 levels defines a subpopulation of highly invasive foam-cell macrophages
    Jason L Johnson
    Bristol Heart Institute, University of Bristol, England
    Arterioscler Thromb Vasc Biol 28:1647-53. 2008
    ..An excess of metalloproteinases (MMPs) over tissue inhibitors of metalloproteinases (TIMPs) may favor atherosclerotic plaque rupture. We compared TIMP levels in nonfoamy and foam-cell macrophages (FCM) generated in vivo...
  84. ncbi Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice
    Yuji Shiraishi
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    J Hypertens 26:1955-65. 2008
    ..In the present study, we investigated the enhancing effect of urotensin II on atherosclerosis in apolipoprotein E-knockout mice and its suppression by 4-aminoquinoline, an urotensin II receptor-selective antagonist...
  85. ncbi Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation
    M Klouche
    Institute of Medical Microbiology, University of Mainz, Germany
    Circulation 101:1799-805. 2000
    ..Enzymatic, nonoxidative modification transforms LDL to an atherogenic molecule (E-LDL) that activates complement and macrophages and is present in early atherosclerotic lesions...
  86. pmc Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells
    Jenny Persson
    Department of Clinical Sciences Malmo, Clinical Research Center, UMAS, Lund University, Sweden
    BMC Immunol 9:70. 2008
    ..The lipid-filled cells are referred to as macrophage foam cells, a key feature of atherosclerotic plaques...
  87. ncbi Mechanisms of disease: macrophage-derived foam cells emerging as therapeutic targets in atherosclerosis
    Robin P Choudhury
    Department of Cardiovascular Medicine, at the University of Oxford, Oxford, UK
    Nat Clin Pract Cardiovasc Med 2:309-15. 2005
    ..From early fatty-streak lesions to advanced plaques, macrophage-derived foam cells are integral to the development and progression of atherosclerosis...
  88. ncbi Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages
    Chao ke Tang
    Institute of Cardiovascular Disease of Nanhua University, Hengyang 421001, China
    Acta Pharmacol Sin 25:581-6. 2004
    ..To study the effect of oxidized low density lipoprotein (ox-LDL) on ATP binding cassette transporter A1 (ABCA1) in THP-1 macrophages...
  89. ncbi Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP-1 derived foam cells exposed to tumor necrosis factor-alpha
    Yan fu Wang
    Department of Cardiology, Affiliated Hospital, Jining Medical College, 272029, Shandong, China
    Phytother Res 24:393-8. 2010
    ..the effects of APS on ABCA1 expression, cholesterol effluent rate and total cholesterol content of THP-1 derived foam cells exposed to TNF-alpha were investigated...
  90. ncbi 8-isoprostane increases scavenger receptor A and matrix metalloproteinase activity in THP-1 macrophages, resulting in long-lived foam cells
    H Scholz
    Rikshospitalet University Hospital, University of Oslo, Norway
    Eur J Clin Invest 34:451-8. 2004
    ..Based on the important role of foam cells in the initiation and progression of atherosclerosis we hereby examined the ability of 8-isoprostane to modulate ..
  91. ncbi Intercellular adhesion molecule-1 and vascular endothelial growth factor expression kinetics in macrophage-derived foam cells
    Peng Yuan Yang
    Department of Pharmacology, School of Pharmacy, The Second Military Medical University, 101 Guo He Road, Shanghai 200433, China
    Life Sci 74:471-80. 2003
    Macrophage-derived foam cells seem to play an important role during inflammatory response of atherosclerosis, in which the overexpression of intercellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) are ..
  92. ncbi Panax notoginseng saponins decrease cholesterol ester via up-regulating ATP-binding cassette transporter A1 in foam cells
    Yi Jia
    Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, 30 Gaotanyan, Shapingba, Chongqing 400038, People s Republic of China
    J Ethnopharmacol 132:297-302. 2010
    ..This study was designed to examine the relationship of PNS with cholesterol ester in foam cells sourced from macrophages and the effect of PNS on the expression of ATP-binding cassette transporter A1 (ABCA1).
  93. pmc C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 180:4316-22. 2008
    The formation of low-density lipoprotein (LDL) cholesterol-loaded macrophage foam cells contributes to the development of atherosclerosis...
  94. ncbi An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells
    Li Jun Luo
    Department of Stomatology, Shanghai Jiading Central Hospital, China
    Cell Signal 24:1889-98. 2012
    ..density lipoprotein (ox-LDL) by macrophages usually leads to the formation of lipid-laden macrophages known as "foam cells," and this process plays an important role in the development of atherosclerosis...
  95. pmc Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells
    Nadezhda S Sabeva
    Pharmaceutical Sciences, College of Pharmacy, Cardiovascular Research Center and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0082, USA
    J Nutr Biochem 22:777-83. 2011
    ..ABCG1 abundance, cholesterol efflux and inflammatory cytokine secretion were determined in cultured macrophage foam cells. Among the commonly consumed phytosterols, stigmasterol increased expression of ABCA1 and ABCG1 and increased ..
  96. ncbi Hydrazine compounds inhibit glycation of low-density lipoproteins and prevent the in vitro formation of model foam cells from glycolaldehyde-modified low-density lipoproteins
    B E Brown
    Free Radical Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW, 2050, Australia
    Diabetologia 49:775-83. 2006
    ..Such 'foam cells' are a hallmark of atherosclerosis...
  97. ncbi Acyl-coenzymeA (CoA):cholesterol acyltransferase inhibition in rat and human aortic smooth muscle cells is nontoxic and retards foam cell formation
    James X Rong
    Marc and Ruti Bell Vascular Biology Research Program of the Leon H Charney Division of Cardiology, Department of Medicine, New York, NY 10016, USA
    Arterioscler Thromb Vasc Biol 25:122-7. 2005
    Studies in vitro and in vivo of macrophage foam cells have shown evidence of cytotoxicity after acyl-CoA:cholesterol acyltransferase (ACAT) inhibition...
  98. ncbi Pharmacokinetic analysis of the uptake of liposomes by macrophages and foam cells in vitro and their distribution to atherosclerotic lesions in mice
    Sumio Chono
    Department of Pharmaceutics, Hokkaido Pharmaceutical University, Otaru City, Japan
    Drug Metab Pharmacokinet 21:37-44. 2006
    ..carrier for atherosclerotic therapy, a pharmacokinetic analysis of the uptake of liposomes by macrophages and foam cells in vitro and their distribution to atherosclerotic lesions in mice was carried out...
  99. ncbi Increased expression of heme oxygenase-1 and bilirubin accumulation in foam cells of rabbit atherosclerotic lesions
    M Nakayama
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Japan
    Arterioscler Thromb Vasc Biol 21:1373-7. 2001
    ..and immunohistochemistry revealed that mRNA and protein of HO-1 are induced in endothelial cells and foam cells (lipid-filled macrophages) in atherosclerotic lesions...
  100. ncbi Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells
    Junfeng Zhang
    Department of Cardiology, No 3 People s Hospital, Medical College of Shanghai Jiaotong University, Mohe road 50, Shanghai, 201900, People s Republic of China
    Int J Cardiol 117:373-80. 2007
    ..the involvement of EMMPRIN in the process of atherosclerosis, we characterized its expression profile in macrophages and foam cells, as well as its potential modulation by peroxisome proliferator-activated receptors (PPARs) agonists.
  101. ncbi Microcalcifications of breast cancer and atypical cystic lobules associated with infiltration of foam cells expressing osteopontin
    Tetsunari Oyama
    Second Department of Pathology, Gunma University School of Medicine, Showa machi 3 39 22, Maebashi, Gunma 371 8511, Japan
    Virchows Arch 440:267-73. 2002
    ..The differences in the morphology of the calcifications and the intraductal contents suggest that the mechanism leading to the osteopontin production might vary depending on the underlying lesion...

Research Grants66

  1. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..esters (CEs) are prominently found in adrenals and ovaries under physiological conditions and in macrophage foam cells in atherosclerotic lesions under pathophysiological conditions...
  2. Inducible Macrophage Specific Gene Expression in Diseases
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
    ..Atherosclerotic plaques will be analyzed for expression of Cre in lesion macrophages and foam cells. This macrophage-specific Cre- expressing Apoe knockout model will be made available to laboratories studying ..
  3. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..Additionally, we recently showed that human THP1 macrophage foam cells synthesize and release 2AG and PG-Gs into the culture medium and levels of these bioactive lipids are augmented ..
  4. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2013
    ..This pathway is intertwined with the autophagic machinery, recently shown to regulate cholesterol efflux from foam cells, and with the inflammatory response...
  5. Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance &Obesity
    LIZA MAKOWSKI HAYES; Fiscal Year: 2012
    ..In fat tissue MPs accumulate lipids as obesity increases similar to the formation of MPs into cholesterol-laden foam cells in an atherosclerotic lesion, where MPs are known to play a similar central role in the formation of plaques...
  6. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2010
    ..of atherosclerosis mainly through two mechanisms: 1) releasing inflammatory mediators, and 2) forming foam cells. An uncontrolled macrophage uptake of E-/B48 lipoproteins could be a mechanism underlying foam cell formation in ..
  7. Myeloid cell interactions with T cells in atherosclerosis
    Klaus F Ley; Fiscal Year: 2013
    ..Specific aim 1 is to test which subsets of myeloid cells become foam cells in the aortic wall, using aortic wall flow cytometry and multiphoton live cell imaging in GFP-tagged Apoe-/- ..
  8. GPCR Kinase-2 in TNFalpha Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2013
    ..In addition to becoming foam cells upon uptake of modified lipoproteins in the vessel walls, macrophages also mediate the inflammatory responses ..
  9. Does Diabetic Hyperglycemia Regulate Atherosclerosis Progression and Regression?
    ROBERT RAFFAI; Fiscal Year: 2013
    ..free cholesterol levels, thereby promoting the unfolded protein response and premature apoptosis of macrophage foam cells. Lastly, we will test the hypothesis that high density lipoproteins isolated from hyperglycemic Apoeh/hLdlr-/-..
  10. Green Tea Nanocarriers: A Promising Approach for the Prevention and Treatment of
    Shu Wang; Fiscal Year: 2011
    ..up cholesterol-rich low- density lipoprotein (LDL), leading to the formation of cholesterol-laden macrophages (foam cells), which characterize early atherosclerotic lesions...
  11. Targeting the Foam Cell to Prevent Atherosclerosis
    ANTONIO PAUL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Summary Lipid-laden macrophages or "foam cells" play crucial roles in all the stages of atherogenesis, from lesion initiation to plaque rupture...
  12. Cholesterol Ester Hydrolysis and Cholesterol Efflux
    Shobha Ghosh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Presence of cholesteryl ester-laden macrophage foam cells is one of the most prominent characteristics of an atherosclerotic lesion...
  13. Hepatic Cholesteryl Ester Metabolism and Cholesterol Elimination
    Shobha Ghosh; Fiscal Year: 2013
    ..g., macrophage foam cells, and this reaction is catalyzed by a neutral cholesteryl ester hydrolase (CEH)...
  14. The anti-inflammatory mRNA-binding protein ZFP36 in Obesity and Metabolism
    CALEB BENJAMIN KALLEN; Fiscal Year: 2013
    ..Little is known about the function of ZFP36 in adipose depot macrophages and adipocytes or in macrophage foam cells of atherosclerotic lesions. No comprehensive description of ZFP36-bound mRNA targets exists for these cell types...
  15. CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSIS
    EDWARD FRANKLIN PLOW; Fiscal Year: 2013
    ..The unexpected findings that plasminogen controls macrophage uptake of oxidized lipoproteins to form foam cells and additionally regulates expression of proatherogenic genes in these cells will be investigated in Aim 3...
  16. DIETARY ETIOLOGIES OF HEART DISEASE AND CANCER
    Eric B Rimm; Fiscal Year: 2013
    ..of scavenger receptors on macrophages that facilitate the rapid influx of oxidized lipid particles to produce foam cells and early atherosclerotic lesions has been instrumental in the basic understanding of atherogenesis...
  17. CELLULAR AND MOLECULAR BIOLOGY OF LIPOPROTEIN METABOLISM
    Michael C Phillips; Fiscal Year: 2013
    ..cells and serum, and the impact on cholesterol flux of the hydrolysis of cholesteryl est droplets in macrophage foam cells. Project 2 aims to understand human apolipoprotein (apo) A-l structure-function and the molecular mechanisms by ..
  18. The role of adenosine kinase in atherosclerosis
    Yuqing Huo; Fiscal Year: 2013
    ..monocyte recruitment to the arterial vesselwall and their subsequent transformation to lipid-enriched foam cells initiate and sustain atherosclerosis...
  19. Nucleotide-Mediated Foam Cell Formation in Smooth Muscle Cells
    TIXIEANNA DISSMORE; Fiscal Year: 2012
    ..formation has been extensively studied, little is known about how vascular smooth muscle cells (VSMCs) become foam cells. Internalization of matrix retained and aggregated LDL may involve the actin cytoskeleton in manner that ..
  20. Defective isoforms of ApoE induce atherogenesis via unfolded protein responses
    Hong Yang; Fiscal Year: 2013
    ..demonstrate that the remnant lipoproteins obtained from ApoE-/- mice is able to transform macrophages into foam cells, and that foam cell formation induced by ApoE-free remnant lipoproteins coincides with an enhanced ..
  21. Role and Regulation of CCR7 in Regression of Atherosclerotic Lesions
    Jonathan E Feig; Fiscal Year: 2010
    ..Using laser capture microscopy to capture foam cells, important mediators in plaque pathophysiology, we studied gene expression changes specifically in these cells ..
  22. Study of Lupus Vascular and Bone Longterm Endpoints
    Rosalind Ramsey-Goldman; Fiscal Year: 2011
    ..of a large number of genes important for lipid metabolism and transport, which promote the formation of foam cells. Moreover, there is upregulation of many genes important for function of osteoclasts, even though these cells ..
  23. Rho kinase in immune-mediated atherosclerosis
    William A Boisvert; Fiscal Year: 2010
    ..bone marrow of the above mice, we will examine the ability of the macrophages to phagocytose lipid and become foam cells in the presence or absence of ROCK...
  24. Effects of Anti-miR-33 on Atherosclerosis Regression and RCT in Nonhuman Primates
    RYAN EUGENE TEMEL; Fiscal Year: 2013
    ..be due to the role of HDL in reverse cholesterol transport (RCT), a process whereby cholesterol from macrophage foam cells in atherosclerotic plaques is effluxed to HDL, transported to the liver, and excreted in the feces...
  25. Shear Stress and Mechnaically Unstable Plaque
    Tzung K Hsiai; Fiscal Year: 2010
    ..Immunohistochemistry will validate oxidative content, including oxidized low density lipoprotein (oxLDL), foam cells and intimal calcification, in the regions exposed to atherogenic hemodynamics...
  26. Molecular Regulation of Atherosclerosis Regression
    Edward A Fisher; Fiscal Year: 2013
    ..over a relatively short time, with depletion of the majority of CD68+ cells (which are primarily macrophages and foam cells)...
  27. 12/15-lipoxygenase, Insulin-like Growth Factor-1 and Atherosclerosis
    Sergiy Sukhanov; Fiscal Year: 2013
    ..Atherosclerosis is an inflammatory disease in which macrophages and macrophage-derived foam cells play a pre-dominant role...
  28. ABCA1/ABCG1 in myeloid populations and atherogenesis
    ALAN RICHARD TALL; Fiscal Year: 2013
    ..anti-atherogenic effect of HDL is believed to be mediated by cholesterol efflux from atheromatous macrophage foam cells to HDL or apoA-1, a process mediated in part by the ATP binding cassette transporters ABCA1 and ABCG1...
  29. Systems analysis of transcriptional interactions underlying foam cell formation
    Stephen A Ramsey; Fiscal Year: 2013
    ..b>Foam cells secrete pro-inflammatory mediators and contribute to lesion progression...
  30. Novel Regulatory Pathway in Prevention of Atherosclerosis
    Shunlin Ren; Fiscal Year: 2013
    ..Macrophages are the most prominent cell type in atherosclerotic lesions. The lipid-laden macrophages (foam cells) formation and subsequent inflammation in the arterial wall are the major pathogenesis for development of the ..
  31. Human ApoE4 and Foam Cell Formation
    EMMANUEL UGOCHUKWU OKORO; Fiscal Year: 2011
    ..By elucidating the role that ApoE4-containing lipoproteins play in the formation of foam cells, an early event in the development of atherosclerosis, we will provide strategies for treatment or prevention of ..
  32. Mechanism of Lysosome Functional Impairment in Cholesterol-engorged Foam Cells
    WALTER G JEROME; Fiscal Year: 2011
    ..Lysosomal sterol accumulation in macrophage foam cells is a ubiquitous but not well-understood aspect of atherosclerosis...
  33. Fortilin, p53, and atherosclerosis
    Ken Fujise; Fiscal Year: 2013
    ..In addition, immunostaining showed that fortilin is overexpressed in M[unreadable] and foam cells within human and mouse atherosclerotic lesions...
  34. Molecular Analysis of the Host Immune Response in Leprosy
    Robert L Modlin; Fiscal Year: 2013
    ..T cell clones derived from T-lep patients are activated by a bacterial lipoglycoprotein (LprG);and iii) foam cells in L-lep lesions are M[unreadable] that contain host-derived oxidized phospholipids, a major component of mildly ..
  35. Monocyte Heterogeneity in Experimental and Human Atherosclerosis
    Filip K Swirski; Fiscal Year: 2013
    ..only do they promote disease through release of inflammatory mediators, but also, as lipid-rich foam cells, they become part of the disease's physical bulk...
  36. The Role of Group 1 CD1-Restricted T Cells in Atherosclerosis
    Chyung Ru Wang; Fiscal Year: 2013
    ..plaques found in humans, and group 1 CD1-restricted T cells can be activated by macrophage-derived foam cells in vitro...
  37. Macrophage Akt and IKKalpha signaling in apoptosis and atherosclerosis
    Macrae F Linton; Fiscal Year: 2013
    ..pathways, PI3K/Akt and NF-kB, and both are constitutively active in macrophages and macrophage-derived foam cells of atherosclerotic lesions...
  38. NEW GENES AND PATHWAYS INVOLVED IN ATHEROSCLEROSIS
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..of the recently identified transporter, ABCG1, that mediates the efflux of cholesterol from macrophage foam cells to HDL. In Project 4: Dr...
  39. CLASS B SCAVENGER RECEPTORS AND FOAM CELL FORMATION
    DENEYS VAN DER WESTHUYZEN; Fiscal Year: 2003
    DESCRIPTION(Adapted from Investigator's Abstract): The formation of cholesterol-loaded foam cells is a key event in atherogenesis...
  40. Sitosterolemia
    Gerald Salen; Fiscal Year: 2003
    ..receptors to produce increased cholesterol and plant sterol deposits such that the cells resemble atherogenic foam cells. Key research objectives are (1) locate and clone the sitosterolemia gene responsible for hyperabsorption that ..
  41. MOLECULAR MECHANISMS OF CELL COMMUNICATION IN ATHEROGENE
    Peter Davies; Fiscal Year: 1993
    ..between expression in resident endothelial and smooth muscle cells, infiltrating plasma cells, and lipid filled foam cells will be studied as a function of hypercholesterolemia...
  42. MOLECULAR MECHANISMS CELL COMMUNICATIONS/ATHEROGENESIS
    Peter Davies; Fiscal Year: 2002
    ..between expression in resident endothelial and smooth muscle cells, infiltrating plasma cells, and lipid filled foam cells will be studied as a function of hypercholesterolemia...
  43. Molecular Mechanisms That Regulate CD11d Expression
    JOHN NOTI; Fiscal Year: 2004
    ..CD11d is expressed on stem cells, myelomonocytic cells, and strongly on macrophage foam cells, and splenic red pulp and alveolar macrophages...
  44. FORM CELL APO (A)/LP(A) RECEPTOR--CLONING AND FUNCTION
    Ira Tabas; Fiscal Year: 2002
    Our laboratory has discovered a cell-surface protein on cholesterol-loaded macrophages and smooth muscle cells (foam cells) that can mediate the specific binding, internalization, and degradation of lipoprotein(a)[Lp(a)] & apoprotein(..
  45. MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISM
    Maria Lopes Virella; Fiscal Year: 2001
    ..immune complexes (LDL-IC) by human monocyte-derived macrophages induces the transformation of these cells into foam cells and promotes their activation leading to a paradoxical increase in LDL receptor cell surface expression and to ..
  46. PRESERVATION OF HDL FUNCTION DURING EARLY ATHEROGENESIS
    JOHN BIELICKI; Fiscal Year: 2002
    ..High density lipoproteins (HDL) promote the efflux of excess cholesterol from macrophage foam cells thus reversing the atherosclerotic process...
  47. VCAM-1 AND CHEMOKINES AND MONOCYTE RECRUITMENT
    Anthony Rosenzweig; Fiscal Year: 2000
    ..These mononuclear cells are predominantly monocytes which give rise to foam cells. Lymphocytes comprise 5 to 20 percent of the mononuclear cell population and are predominantly of the memory (..
  48. CHOLESTERYL ESTER FLUIDITY IN ATHEROSCLEROSIS RESEARCH
    Julian Snow; Fiscal Year: 1991
    ..These cells become the foam cells characteristic of atherosclerotic plaque...
  49. SYNTHESIS OF HELMINTHOSPOROL ANALOGS AS ACAT INHIBITORS
    EDUARD CASILLAS; Fiscal Year: 2004
    ..These plaques originate principally from macrophage-derived foam cells, which store elevated concentrations of esterifled cholesterol...
  50. ANTIOXIDANTS AND THE KINETICS OF LIPOPROTEIN OXIDATION
    William Stone; Fiscal Year: 1992
    ..LDL modified by in vitro oxidative stress is known to be taken up by cultured macrophages which transform into "foam cells" similar to those observed in early atherosclerotic lesions...
  51. MACROPHAGE CHYLOMICRON/B48 RECEPTOR, BINDING MECHANISMS
    William Bradley; Fiscal Year: 2004
    ..It is constitutively expressed on monocyte-macrophages (MM), including human atherosclerotic foam cells and bone marrow precursors, and endothelial cells (ECs), cells intimately involved in hemostasis and ..
  52. VLDL, ATHEROSCLEROSIS, AND THROMBOSIS-MECHANISTIC LINKS
    William Bradley; Fiscal Year: 1993
    ..due to abnormal binding to the LDL receptor and/or a distinct macrophage receptor, converting macrophages into foam cells (this is exacerbated by thrombin cleavage of TGRLP)...
  53. GLYCOSAMINOGLYCAN EFFECT ON ARTERIAL SMOOTH MUSCLE CELLS
    Samuel Smith; Fiscal Year: 1990
    ..The hallmark feature of early atherosclerosis is accumulation of esterified cholesterol in foam cells originating from either monocytes migrating into the arterial wall or from constituent smooth muscle cells...
  54. Proteomic Analysis of Persistent Chlamydia pneumoniae
    James Summersgill; Fiscal Year: 2004
    ..is a chronic inflammatory disease featuring an increased accumulation of smooth muscle cells, macrophages, foam cells, T-cells and lipids within the arterial intima in response to injury. Evidence exits that localizes C...
  55. ARTERIAL WALL PROTEOGLYCANS AND FOAM CELL FORMATION
    Parakat Vijayagopal; Fiscal Year: 1993
    The lipid-laden foam cells of atheromatous lesions belong in part to the monocytemacrophage lineage...
  56. MONOCYTE RECEPTORS MEDIATING ADHESION--ENDOTHELIAL CELL
    Israel Charo; Fiscal Year: 1992
    ..Data from several laboratories indicates that circulating monocytes are the precursors of the lipid-laden foam cells found beneath the endothelium in cholesterol-fed experimental animals...
  57. The Role of RNase L in Cardiovascular Diseases
    Aimin Zhou; Fiscal Year: 2006
    ..the regulatory expression of proinflammatory genes, uptake of oxidized low-density lipoprotein (oxLDL) to form foam cells and apoptosis, remains to be fully understood...
  58. REGULATION OF MONOCYTE DIFFERENTIATION BY ENDOTHELIUM
    Ross Gerrity; Fiscal Year: 2001
    ..Once recruited, macrophages sequester lipid via uptake of modified and oxidized LDL and become foam cells. The investigators and others have suggested a protective lipid clearance role of the monocyte in early ..
  59. MECHANISMS AND PATHWAYS OF CELL CHOLESTEROL TRANSPORT
    Armando Mendez; Fiscal Year: 1999
    ..from cells to gain further understanding of the processes involved in regression or formation of lipid laden foam cells as occur in atherosclerosis...
  60. Investigation of ACAT Functions Using Knockout
    Robert Farese; Fiscal Year: 2006
    ..the synthesis and secretion of apolipoprotein (apo) B-containing lipoproteins, and the formation of macrophage foam cells in atherosclerotic lesions...
  61. DISTINCT HUMAN MACROPHAGE RECEPTOR FOR ABNORMAL VLDL
    Matthew Brown; Fiscal Year: 2006
    ..unique receptor for dietary ppTGRLP, the apoB48 receptor (apoB48R), found in human monocyte-macrophages and in foam cells in arterial lesions...
  62. MACROPHAGE LIPOLYTIC ENZYMES AND FOAM CELL FORMATION
    JOHN KHOO; Fiscal Year: 1990
    ..Native LDL is taken up too slowly by macrophages to generate foam cells and this has led to a search for modified forms of LDL that might be taken up more avidly...
  63. Detection of Oxidized LDL in Plasma
    KENNETH DOMBROWSKI; Fiscal Year: 2009
    ..been oxidatively modified, on the other hand, can be avidly taken up by macrophages leading to the formation of foam cells and plaque instability...
  64. HETEROGENEITY OF ARTERIAL MACROPHAGE-DERIVED FOAM CELLS
    Michael Rosenfeld; Fiscal Year: 1993
    ..Initially, macrophage- derived foam cells will be isolated from atherosclerotic rabbit arteries using an enzyme digestion procedure, and purified using ..
  65. IGG FC RECEPTORS AND METABOLISM OF LDL IMMUNE COMPLEXES
    Peter Morganelli; Fiscal Year: 2000
    Macrophage derived foam cells are important elements of atherosclerotic plaque and several well-defined mechanisms exist by which various forms of lipoproteins enter macrophages resulting in foam cell development...
  66. CHLAMYDIA PNEUMONIAE AND MACROPHAGES IN ATHEROSCLEROSIS
    Gerald Byrne; Fiscal Year: 2003
    ..Characteristic changes include development of cholesteryl ester-laden monocytes (foam cells) and oxidation of lipids to form tissue-damaging derivatives...