Genomes and Genes
Summary: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Publications358 found, 100 shown here
- Monocyte and macrophage heterogeneitySiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 5:953-64. 2005..of the macrophage lineage has long been recognized and, in part, is a result of the specialization of tissue macrophages in particular microenvironments...
- Fate mapping analysis reveals that adult microglia derive from primitive macrophagesFlorent Ginhoux
Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Science 330:841-5. 2010Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial...
- Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesEmmanuel L Gautier
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, USA
Nat Immunol 13:1118-28. 2012We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable...
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
- Exploring the full spectrum of macrophage activationDavid M Mosser
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
Nat Rev Immunol 8:958-69. 2008b>Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions...
- A lineage of myeloid cells independent of Myb and hematopoietic stem cellsChristian Schulz
Centre for Molecular and Cellular Biology of Inflammation, New Hunt s House, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 336:86-90. 2012b>Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs)...
- A role for mitochondria in NLRP3 inflammasome activationRongbin Zhou
Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 469:221-5. 2011..This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases...
- Macrophage plasticity and polarization: in vivo veritasAntonio Sica
Istituto Clinico Humanitas IRCCS, Rozzano, Italy
J Clin Invest 122:787-95. 2012..In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of ..
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004..particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue ..
- Alternative activation of macrophages: mechanism and functionsSiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Immunity 32:593-604. 2010..The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
- MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityHajime Kanda
Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
J Clin Invest 116:1494-505. 2006..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
- Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responsePhilip T Liu
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 311:1770-3. 2006..direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide...
- Obesity is associated with macrophage accumulation in adipose tissueStuart P Weisberg
Division of Moleuclar Genetics, Department of Pediatrics, Columbia University, New York, New York 10032, USA
J Clin Invest 112:1796-808. 2003..Of the 100 most significantly correlated genes, 30% encoded proteins that are characteristic of macrophages and are positively correlated with body mass...
- Protective and pathogenic functions of macrophage subsetsPeter J Murray
Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Nat Rev Immunol 11:723-37. 2011b>Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals...
- Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cordKristina A Kigerl
Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
J Neurosci 29:13435-44. 2009b>Macrophages dominate sites of CNS injury in which they promote both injury and repair. These divergent effects may be caused by distinct macrophage subsets, i.e...
- Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapyDavid G DeNardo
Department of Pathology, University of California, San Francisco, USA
Cancer Discov 1:54-67. 2011....
- Interferon-gamma: an overview of signals, mechanisms and functionsKate Schroder
Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
J Leukoc Biol 75:163-89. 2004..In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-alpha, interleukin-4, type I IFNs, and lipopolysaccharide are discussed...
- Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shockEsmerina Tili
Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Columbus, OH 43210, USA
J Immunol 179:5082-9. 2007..LPS stimulation of mouse Raw 264.7 macrophages resulted in the up-regulation of miR-155 and down-regulation of miR-125b levels...
- Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesisLudovic Arnold
Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
J Exp Med 204:1057-69. 2007b>Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro...
- CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesitySatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Nat Med 15:914-20. 2009..The infiltration by CD8(+) T cells preceded the accumulation of macrophages, and immunological and genetic depletion of CD8(+) T cells lowered macrophage infiltration and adipose tissue ..
- Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFV A Fadok
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Clin Invest 101:890-8. 1998..Phagocytosis of apoptotic cells by macrophages has been suggested to be a quiet process that does not lead to production of inflammatory mediators...
- Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionJesus F Salazar-Gonzalez
University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 206:1273-89. 2009..and replicated efficiently in primary human CD4(+) T lymphocytes but much less so in monocyte-derived macrophages. Transmitted viruses were CD4 and CCR5 tropic and demonstrated concealment of coreceptor binding surfaces of ..
- Macrophage-specific PPARgamma controls alternative activation and improves insulin resistanceJustin I Odegaard
Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
Nature 447:1116-20. 2007..Conversely, disruption of Mcp1 or its receptor Ccr2 impairs migration of macrophages into adipose tissue, thereby lowering adipose tissue inflammation and improving insulin sensitivity...
- Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesAlberto Mantovani
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
Trends Immunol 23:549-55. 2002..Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states...
- Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humansSaverio Cinti
Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
J Lipid Res 46:2347-55. 2005..We demonstrate that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that ..
- Insulin sensitivity: modulation by nutrients and inflammationSimon Schenk
Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California 92093, USA
J Clin Invest 118:2992-3002. 2008..Overall, we provide our integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity...
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteriaEdward A Miao
Institute for Systems Biology, Seattle, Washington, USA
Nat Immunol 11:1136-42. 2010b>Macrophages mediate crucial innate immune responses via caspase-1-dependent processing and secretion of interleukin 1β (IL-1β) and IL-18...
- Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 productionKrisztian Nemeth
National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
Nat Med 15:42-9. 2009..Monocytes and/or macrophages from septic lungs made more IL-10 when prepared from mice treated with BMSCs versus untreated mice...
- Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingHaitao Wen
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Nat Immunol 12:408-15. 2011..Furthermore, IL-1β affects insulin sensitivity through tumor necrosis factor-independent and dependent pathways. These findings provide insights into the association of inflammation, diet and T2D...
- Distinct role of macrophages in different tumor microenvironmentsClaire E Lewis
Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
Cancer Res 66:605-12. 2006b>Macrophages are prominent in the stromal compartment of virtually all types of malignancy...
- Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expressionFernando O Martinez
Istituto Clinico Humanitas, Rozzano, Italy
J Immunol 177:7303-11. 2006..6) The chemokinome of polarized macrophages is profoundly diverse and new differentially expressed chemokines are reported...
- Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesMaximiliano G Gutierrez
Instituto de Histologia y Embriologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo CONICET, Mendoza 5500, Argentina
Cell 119:753-66. 2004..Here we show that stimulation of autophagic pathways in macrophages causes mycobacterial phagosomes to mature into phagolysosomes...
- Obesity-induced inflammatory changes in adipose tissueKathryn E Wellen
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
J Clin Invest 112:1785-8. 2003..1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue...
- The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infectionTakashi Satoh
Laboratory of Host Defense, World Premiere Initiative Immunology Frontier Research Center, Osaka University, Osaka, Japan
Nat Immunol 11:936-44. 2010Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively...
- Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophilsStephen J Galli
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Nat Immunol 12:1035-44. 2011..subpopulations in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils...
- Macrophages: obligate partners for tumor cell migration, invasion, and metastasisJohn Condeelis
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cell 124:263-6. 2006b>Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility...
- Gout-associated uric acid crystals activate the NALP3 inflammasomeFabio Martinon
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nature 440:237-41. 2006..b>Macrophages from mice deficient in various components of the inflammasome such as caspase-1, ASC and NALP3 are defective in ..
- Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta productionTatsuya Saitoh
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nature 456:264-8. 2008..Following stimulation with lipopolysaccharide, a ligand for Toll-like receptor 4 (refs 8, 9), Atg16L1-deficient macrophages produce high amounts of the inflammatory cytokines IL-1beta and IL-18...
- The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapiesL Bingle
Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
J Pathol 196:254-65. 2002The role of macrophages in tumour growth and development is complex and multifaceted...
- Inflammation, atherosclerosis, and coronary artery diseaseGoran K Hansson
Karolinska Institute, Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
N Engl J Med 352:1685-95. 2005
- Macrophage diversity enhances tumor progression and metastasisBin Zhi Qian
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cell 141:39-51. 2010There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is mutagenic and promotes growth...
- Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinKasia Hrecka
Department of Molecular Biology and Microbiology, Case School of Medicine, Cleveland, Ohio 44106, USA
Nature 474:658-61. 2011b>Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses...
- Tumor-associated macrophages (TAM) as major players of the cancer-related inflammationG Solinas
Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
J Leukoc Biol 86:1065-73. 2009..Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.
- Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia poolBahareh Ajami
University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
Nat Neurosci 14:1142-9. 2011..EAE) mouse model, two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory macrophages, accrue from proliferating resident precursors and recruitment of blood-borne progenitors, respectively...
- Macrophages: master regulators of inflammation and fibrosisThomas A Wynn
Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Semin Liver Dis 30:245-57. 2010b>Macrophages are found in close proximity with collagen-producing myofibroblasts and indisputably play a key role in fibrosis...
- Macrophages, innate immunity and cancer: balance, tolerance, and diversityAlberto Mantovani
Istituto Clinico Humanitas IRCCS, Rozzano, Italy
Curr Opin Immunol 22:231-7. 2010..Tumor-associated macrophages (TAM) have served as a paradigm for cancer promoting inflammation...
- Cryopyrin activates the inflammasome in response to toxins and ATPSanjeev Mariathasan
Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 440:228-32. 2006..Here we show that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 ..
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceHaiyan Xu
Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
J Clin Invest 112:1821-30. 2003..Histologically, there is evidence of significant infiltration of macrophages, but not neutrophils and lymphocytes, into WAT of obese mice, with signs of adipocyte lipolysis and formation ..
- GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effectsDa Young Oh
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
Cell 142:687-98. 2010..7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown...
- Nonresolving inflammationCarl Nathan
Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA
Cell 140:871-82. 2010..Nonetheless, multiple mechanisms normally ensure resolution. Cells like macrophages switch phenotypes, secreted molecules like reactive oxygen intermediates switch impact from pro- to anti-..
- Macrophages in the pathogenesis of atherosclerosisKathryn J Moore
Department of Medicine, New York University Medical Center, NY 10016, USA
Cell 145:341-55. 2011..layer of blood vessels leads to the recruitment of monocytes, the cells of the immune system that give rise to macrophages and dendritic cells...
- Innate immune activation through Nalp3 inflammasome sensing of asbestos and silicaCatherine Dostert
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Science 320:674-7. 2008..Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor...
- Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytesDaigo Hashimoto
Department of Oncological Sciences and Tisch Cancer Institute, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 38:792-804. 2013Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes...
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationVeit Hornung
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:847-56. 2008..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal...
- Transforming growth factor-beta regulation of immune responsesMing O Li
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Annu Rev Immunol 24:99-146. 2006..the regulation of chemotaxis, activation, and survival of lymphocytes, natural killer cells, dendritic cells, macrophages, mast cells, and granulocytes...
- Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisSimon Yona
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 38:79-91. 2013Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense...
- Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factorsJalees Rehman
Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
Circulation 107:1164-9. 2003..It is not known whether the proangiogenic effects are a result of such events as endothelial differentiation and subsequent proliferation of EPCs or secondary to secretion of angiogenic growth factors...
- MicroRNA-155 is induced during the macrophage inflammatory responseKonstantin D Taganov
Department of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 104:1604-9. 2007..In the present study, we use microarray technology to identify miRNAs induced in primary murine macrophages after exposure to polyriboinosinic:polyribocytidylic acid or the cytokine IFN-beta...
- Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3L Alexopoulou
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
Nature 413:732-8. 2001..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
- Monocyte recruitment during infection and inflammationChao Shi
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Rev Immunol 11:762-74. 2011..The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review...
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptorY Feng
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
Science 272:872-7. 1996..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
- Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificityEric M Kofoed
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 477:592-5. 2011..Our results identify NAIPs as immune sensor proteins and provide biochemical evidence for a simple receptor-ligand model for activation of the NAIP-NLRC4 inflammasomes...
- Cell-mediated immune responses in tuberculosisAndrea M Cooper
Trudeau Institute, Saranac Lake, New York 12983, USA
Annu Rev Immunol 27:393-422. 2009..We must also determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences...
- CpG motifs in bacterial DNA and their immune effectsArthur M Krieg
Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
Annu Rev Immunol 20:709-60. 2002..CpG ODN also enhance the development of acquired immune responses for prophylactic and therapeutic vaccination...
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
- A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumorsJeffrey Wyckoff
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:7022-9. 2004..Although the presence of macrophages in primary tumors is associated with increased metastatic potential, the mechanistic basis for this observation ..
- Macrophages, inflammation, and insulin resistanceJerrold M Olefsky
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
Annu Rev Physiol 72:219-46. 2010..of obesity results from a combination of altered functions of insulin target cells and the accumulation of macrophages that secrete proinflammatory mediators...
- Non-canonical inflammasome activation targets caspase-11Nobuhiko Kayagaki
Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
Nature 479:117-21. 2011..mice, that caspase-11 (also known as caspase-4) is critical for caspase-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae...
- Conditional gene targeting in macrophages and granulocytes using LysMcre miceB E Clausen
Institute for Genetics, University of Cologne, Germany
Transgenic Res 8:265-77. 1999..one of two different loxP-flanked target genes tested, a deletion efficiency of 83-98% was determined in mature macrophages and near 100% in granulocytes...
- Adipose tissue, adipokines, and inflammationGiamila Fantuzzi
Department of Human Nutrition, University of Illinois at Chicago, USA
J Allergy Clin Immunol 115:911-9; quiz 920. 2005..b>Macrophages are components of adipose tissue and actively participate in its activities...
- Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cellsMei Yang
Breast Tumor Center, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, PR China
Mol Cancer 10:117. 2011Tumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4+ T cells...
- Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in miceRavid Shechter
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
PLoS Med 6:e1000113. 2009Although macrophages (MPhi) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate...
- Tumor-associated macrophages and survival in classic Hodgkin's lymphomaChristian Steidl
Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada
N Engl J Med 362:875-85. 2010..Current prognostic models predict the outcome of treatment with imperfect accuracy, and clinically relevant biomarkers have not been established to improve on the International Prognostic Score...
- SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesHichem Lahouassa
Institut National de la Santé et de la Recherche Médicale U1016, Institut Cochin, Paris, France
Nat Immunol 13:223-8. 2012..Nucleotide-pool depletion could be a general mechanism for protecting cells from infectious agents that replicate through a DNA intermediate...
- Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model systemStefan Pukatzki
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:1528-33. 2006..cholerae cells toward Dictyostelium amoebae and mammalian J774 macrophages by a contact-dependent mechanism...
- IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1Stephen J Jenkins
Institute of Immunology and Infection Research, School of Biological Sciences and 2 Medical Research Council Centre for Inflammation Research and 3 The Roslin Institute and Royal Dick School of Veterinary Studies, College of Medicine and Veterinary Medicine University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK
J Exp Med 210:2477-91. 2013b>Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells...
- MiR-33 contributes to the regulation of cholesterol homeostasisKatey J Rayner
Department of Medicine, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
Science 328:1570-3. 2010..In mouse macrophages, miR-33 also targets ABCG1, reducing cholesterol efflux to nascent high-density lipoprotein (HDL)...
- Transcriptional regulation of macrophage polarization: enabling diversity with identityToby Lawrence
Centre d Immunologie Marseille Luminy, Parc Scientifique and Technologique de Luminy, Case 906, F 13288 Marseille, France
Nat Rev Immunol 11:750-61. 2011In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone...
- Macrophage activation and polarizationFernando Oneissi Martinez
Istituto Clinico Humanitas, I 20089 Rozzano, Italy
Front Biosci 13:453-61. 2008b>Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs...
- Adipose tissue remodeling and obesityKai Sun
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8549, USA
J Clin Invest 121:2094-101. 2011....
- An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowM B Lutz
Department of Dermatology, University of Erlangen, Germany
J Immunol Methods 223:77-92. 1999..This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations. It will be valuable to study DC biology notably at the molecular level...
- Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via IpafEdward A Miao
Institute for Systems Biology, Seattle, Washington 98103, USA
Nat Immunol 7:569-75. 2006b>Macrophages respond to Salmonella typhimurium infection via Ipaf, a NACHT-leucine-rich repeat family member that activates caspase-1 and secretion of interleukin 1beta...
- Macrophages in atherosclerosis: a dynamic balanceKathryn J Moore
Department of Medicine, Leon H Charney Division of Cardiology, Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York 10016, USA
Nat Rev Immunol 13:709-21. 2013..imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall...
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisBin Zhi Qian
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
Nature 475:222-5. 2011b>Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells...
- Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processingPetr Broz
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
Cell Host Microbe 8:471-83. 2010..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
- The Legionella pneumophila replication vacuole: making a cosy niche inside host cellsRalph R Isberg
Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nat Rev Microbiol 7:13-24. 2009The pathogenesis of Legionella pneumophila is derived from its growth within lung macrophages after aerosols are inhaled from contaminated water sources...
- SOCS proteins, cytokine signalling and immune regulationAkihiko Yoshimura
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Nat Rev Immunol 7:454-65. 2007..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
- Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesLuigi Franchi
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Immunol 7:576-82. 2006Gram-negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase-1 cleavage and secretion of interleukin 1beta, a powerful host response factor...
- Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2Benjamin N Gantner
Department of Immunology, University of Washington, Seattle, 98103, USA
J Exp Med 197:1107-17. 2003..Dectin-1, which is expressed at low levels on macrophages and high levels on dendritic cells, contains an immunoreceptor tyrosine-based activation motif-like signaling ..
- Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaBDongsheng Cai
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
Nat Med 11:183-90. 2005..These findings indicate that lipid accumulation in the liver leads to subacute hepatic 'inflammation' through NF-kappaB activation and downstream cytokine production. This causes insulin resistance both locally in liver and systemically...
- A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysM T Audrey Nguyen
Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 282:35279-92. 2007..BMDCs) have heightened proinflammatory activity compared with F4/80(+)CD11b(+)CD11c(-) bone marrow-derived macrophages and that the proinflammatory activity and JNK phosphorylation of BMDCs, but not bone marrow-derived macrophages,..
- Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?C Y Cheung
Department of Microbiology, University of Hong Kong, Queen Mary Hospital, SAR, Hong Kong, China
Lancet 360:1831-7. 2002..The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role...
- The many faces of macrophage activationDavid M Mosser
Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 73:209-12. 2003
- Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal EnvironmentDirk Schnappinger
Department of Microbiology and Immunology, Cornell University, 1300 York Avenue, New York, NY 10021, USA
J Exp Med 198:693-704. 2003..the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric oxide (NO) synthase 2-deficient mice before and after immunologic activation...
- Transcriptional response of Candida albicans upon internalization by macrophagesMichael C Lorenz
Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
Eukaryot Cell 3:1076-87. 2004..albicans to phagocytosis by mammalian macrophages using genomic transcript profiling. This analysis reveals a dramatic reprogramming of transcription in C...
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelinationVeronique E Miron
MRC Centre for Regenerative Medicine, Multiple Sclerosis Society Centre for Translational Research, University of Edinburgh, Edinburgh, UK
Nat Neurosci 16:1211-8. 2013..This involves an innate immune response consisting of microglia and macrophages, which can be polarized to distinct functional phenotypes: pro-inflammatory (M1) and anti-inflammatory or ..
- Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skinSamira Tamoutounour
Centre d Immunologie de Marseille Luminy CIML, UM2 Aix Marseille Université, 13288 Marseille Cedex 9, France INSERM U1104, 13288 Marseille Cedex 9, France CNRS UMR7280, 13288 Marseille Cedex 9, France
Immunity 39:925-38. 2013In the skin, the lack of markers permitting the unambiguous identification of macrophages and of conventional and monocyte-derived dendritic cells (DCs) complicates understanding of their contribution to skin integrity and to immune ..
- The inflammatory response in myocardial infarctionNikolaos G Frangogiannis
Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine and the DeBakey Heart Center, One Baylor Plaza M S F 602, Houston, TX 77030, USA
Cardiovasc Res 53:31-47. 2002..Monocyte-derived macrophages and mast cells may produce cytokines and growth factors necessary for fibroblast proliferation and ..
- IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responsesThomas Krausgruber
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
Nat Immunol 12:231-8. 2011..Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization...
- Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammationStephen J Jenkins
Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
Science 332:1284-8. 2011..We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density...
- TLR4 links innate immunity and fatty acid-induced insulin resistanceHang Shi
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:3015-25. 2006..fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and ..
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..We have successfully tested one of these serpins, Serp-1, in a small phase 2A clinical trial for anti-inflammatory activity in unstable coronary syndromes (Viron Therapeutics, Inc;proprietary information). ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2011..biofilm formation by Porphyromonas gingivalis, cytokine production by LPS- or AGE-stimulated human monocyte/macrophages, matrix metalloproteinase production by IL-12-stimulated human gingival fibroblasts, and AGE-induced inhibition ..
- Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)James D Bryers; Fiscal Year: 2012..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013..We then investigate if PM2.5 exposure induced ER stress response in macrophages is central to adipose inflammation and dysfunction by flow sorting and laser capture microscopy and assessed ..
- Prevention of Acute Lung Injury by IL-6 activated STAT3Ana Moran; Fiscal Year: 2010..Pik3r1 and Lcn2-as well as genes encoding proteins- Gzmb and Prf1-that are expressed by neutrophils, macrophages and cytotoxic T-lymphocytes that infiltrate the lung during systemic inflammatory states such as T/HS...
- Enterococcus faecalis, Colorectal Cancer, and Bystander EffectsMark M Huycke; Fiscal Year: 2012..The role of macrophages in the production of inflammation, dysplasia, and tumor formation in E...
- Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative StressSamantha M Yeligar; Fiscal Year: 2013..In alveolar macrophages (AMs), NADPH oxidase (Nox) 1, Nox2, and Nox4 are critical sources of reactive oxygen species (ROS), and Nox2 is ..
- Immunomodulatory and regenerative effects of mesenchymal stem cells on allograftsNorma S Kenyon; Fiscal Year: 2013..IV MSC post-transplant will result in the induction of T regulatory cells, recruitment of regulatory monocytes/macrophages and endothelial precursors to sites of inflammation (i.e...
- Investigating Mechanism of Intracellular Rotational Transport with Optical TJeffrey N Anker; Fiscal Year: 2012..b>Macrophages are the primary defense cells in the lung responsible for uptake, degradation and clearance of foreign ..
- Trichothecene Toxicity and the Ribotoxic Stress ResponseJames J Pestka; Fiscal Year: 2012..Collectively, these outcomes will positively impact public health by providing a scientific basis for generating sound recommendations relative to these important toxins and appropriate remedial actions should exposures occur. ..
- Iron, Metabolic Regulation and Type 2 Diabetes RiskDonald A McClain; Fiscal Year: 2013..The effects of glucose on hepcidin, and subsequent effects on inflammatory signaling in macrophages and adipocytes, will be examined in mouse models with normal glucose tolerance, hyperphagia, diabetes, and with ..
- Mechanisms of hepcidin effects in the anemia of chronic diseaseRobert T Means; Fiscal Year: 2013..Hepcidin inhibits egress of iron from bone marrow macrophages by downregulation of the iron export protein FPN...
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2013..Finally, CD11c+ macrophage represents the majority of the macrophages recruited into obese adipose tissues...
- Hepcidin-based screening for infantile iron deficiencyMark D Fleming; Fiscal Year: 2010..iron from cells, particularly duodenal intestinal epithelial cells, where iron is absorbed into the body, and macrophages, which recycle iron from effete RBCs...
- Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated DementiaXavier Grana; Fiscal Year: 2010..Importantly, Tat inhibits cyclin T1/CDK9-dependent gene expression of certain genes in macrophages, dendritic cells and B cells via a competition mechanism with specific transcriptional activators...
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2011DESCRIPTION (provided by applicant): Alternative macrophage activation limits immunopathology Macrophages (MF) form a heterogeneous population of mononuclear phagocytes necessary for organ homeostasis, host defense, and immunoregulation...
- Novel Peptide MPO Inhibitors for Treating AtherosclerosisKirkwood A Pritchard; Fiscal Year: 2012..Effects of the inhibitors on MPO activity will be determined in in vitro systems using both purified MPO and macrophages isolated from MPO-/- and transgenic human MPO (Tg-h- MPO+/+) mice...
- Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T cInsoo Kang; Fiscal Year: 2010..For instance, vitamin D3 (VD3) can affect the functions of immune cells including macrophages, dendritic cells (DC), B and T cells...
- Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22Yaya Wang; Fiscal Year: 2013..In Aim 1, I will determine the role of PTPN22 in TLR signaling by using bone-marrow derived macrophages (BMMs) and dendritic cells (BMDCs) from PTPN22 deficient mice...
- Regulation of Innate and Adaptive Immunity in Human COPD and EmphysemaFarrah Kheradmand; Fiscal Year: 2012..In addition to macrophages and neutrophils, lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, ..
- C5a as an Anti-HIV Microbicidal CandidatePHILIPPE ANDRE GALLAY; Fiscal Year: 2013..multiple attractive microbicidal properties: it i) blocks HIV infection of primary targets including T cells, macrophages and dendritic cells;ii) exhibits a broad range of antiviral activity against primary HIV isolates, multi-drug ..
- Lipid Droplet MetabolismFredric B Kraemer; Fiscal Year: 2013....
- Mechanisms of Heme Transport in MacrophagesCARINE CARINE WHITE; Fiscal Year: 2012..Within the reticuloendothelial system, macrophages (M&s) play a major role in the recycling of heme-iron via phagocytosis of senescent red blood cells (i.e...
- The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaSe Te Joseph Huang; Fiscal Year: 2012..human cytotrophoblasts (CTBs) invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (MFs) and dendritic cells (DCs)...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010..white and brown adipose tissues on early adipocyte progenitor cell (APC), in vivo adipogenesis, newly recruited macrophages in adipose tissues, mitochondria content, uncoupling protein (UCP)1 expression, monocyte migration, and ..
- Arginine Availability and Metabolism in the Immune Evasion of H. pyloriKeith T Wilson; Fiscal Year: 2013..We have shown that the regulator of L-Arg uptake in macrophages, cationic amino acid transporter-2 (CAT2), is required for protein expression of iNOS and that its function is ..
- Signaling by Cytoplasmic Tyrosine Kinases in LeukocytesClifford A Lowell; Fiscal Year: 2013..Deletion of SHP-1 in both neutrophils and macrophages (using LysM-Cre) results in no phenotype at all (despite the presence of activated neutrophils)...
- Tumor Microenvironment Interactions in Brain TumorsEric C Holland; Fiscal Year: 2010..The central hypothesis is that stromal cells, particularly macrophages and endothelial cells, provide key factors, such as matrix-degrading enzymes, which are co-opted by the tumor ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2013..IL-1[unreadable], prostaglandin E2, and matrix metalloproteinases (MMP) 1, 2, 3, and 9 release from macrophages and human gingival fibroblasts. Second, it blocks CR3-mediated internalization of P. gingivalis by macrophages...
- Role of Retroelements in Environmental AtherogenesisKenneth S Ramos; Fiscal Year: 2010..is a fibro-proliferative disease associated with endothelial injury, recruitment of inflammatory cells (macrophages and T cells), expansion of vascular smooth muscle cells (vSMCs) and buildup of cholesterol and extracellular ..
- Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA InterferenceAlexandra L Howell; Fiscal Year: 2013..b>Macrophages and dendritic cells (DC) in mucosal tissues express receptors that are triggered by viral proteins and nucleic ..
- Monocyte activation and the role of CD11c in obesity-linked metabolic syndromeHuaizhu Wu; Fiscal Year: 2013..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in monocyte ..
- A2b Adenosine Receptor Regulation of Metabolic Disease and InflammationAnna Eisenstein; Fiscal Year: 2013..Ravid, a Biochemist and expert in vascular and adenosine biology, and Dr. Gokce, a Clinician Scientist with access to human samples and expertise in studying human adipose tissue. ..
- ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURYIrfan Rahman; Fiscal Year: 2013..We have found that SIRT1 levels are drastically reduced in response to CS exposure in macrophages, mouse lung, and in lungs of patients with COPD, and are associated with increased NF-(B activation and release ..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2013..proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages. FABPs bind a variety of unesterified fatty acids and other lipid second messengers and mediate their ..
- EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETIONAnisa Shaker; Fiscal Year: 2012..of Chordin from colonic myofibroblasts and decreases secretion of Interleukin-6 (IL-6) from myofibroblasts and macrophages. We propose that these regulatory events are important because Chordin inhibits bone morphogenetic protein (Bmp)..
- The Role of Vascular MR-Regulated Genes in Vascular Function and DiseaseIris Z Jaffe; Fiscal Year: 2013..abstract_text> ..
- Novel Macrolide Th17 InhibitorsJay K Kolls; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Interleukin-17 can cause lung inflammation and asthma. This project is to indentify drugs that can inhibit IL-17 and lung inflammation. ..
- Characterizing TLR Function of Human Dendritic Cells in the ElderlyAlexander Panda; Fiscal Year: 2012..plans for establishing his independent research program, a pilot study of TLR function in lung-derived alveolar macrophages in bronchoalveolar lavage fluid from young and older individuals will be carried out to obtain pilot data...
- Regulation of NFkappaB activity by the Estrogen ReceptorKendall W Nettles; Fiscal Year: 2012..We propose to use these synthetic compounds to understand the molecular details of this important anti-inflammatory pathway. ..
- Role of the neurogenic inflammatory pathway in the genital tract immune responseRoger G Rank; Fiscal Year: 2010..Chemotactic factors produced as a result of substance P release recruit neutrophils, monocytes, macrophages, and lymphocytes to the local site...
- Regulation of vaccine-induced anti-fungal T17 cellsMARCEL WUETHRICH; Fiscal Year: 2013..Vaccine-induced T17 cells mediated protection by recruiting and activating neutrophils and alveolar macrophages to the alveolar space to augment fungal killing...
- Mechanisms of Angiogenesis in Retinopathy of PrematurityMary Elizabeth Hartnett; Fiscal Year: 2009..We will study the effects of EC- derived NADPH oxidase by depleting animals of macrophages. To change the degree of activation of NADPH oxidase, we will use the 50/10 OIR rescued in supplemental oxygen ..
- Hormonal regulation of a Ca2+/AMPK signaling pathwayAnthony R Means; Fiscal Year: 2013DESCRIPTION (provided by applicant): The overall objective is to define the Ca2+-signaling pathways in macrophages that regulate functions of and genes involved in the inflammatory response...
- Regulation of Astrocyte TIMP-1 in HIV-Associated DementiaJEREL ADAM FIELDS; Fiscal Year: 2011..The disease is characterized by an accumulation of activated and infected macrophages/microglia in the central nervous system, which secrete cytokines, infectious virions and viral proteins that ..
- The Role of Adipocyte-Induced Inflammation in Prostate Tumor ProgressionAIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012..Ultimately, these studies should lead to identification of novel signaling pathways and molecular mechanisms predisposing prostate cells to metastasize to bone. ..
- Growth Hormone Regulation of SH2B1Christin Carter-Su; Fiscal Year: 2013..State-of-the-art microscopes, photoactivable probes, proteomics, cell lines and both primary macrophages and MEFs from SH2B1-/- mice, will also be used...
- Knockdown of Gene Expression in Immune Cells in Humanized MiceJudy Lieberman; Fiscal Year: 2010..aim is to test and optimize CD4- AsiCs for systemic knockdown of gene expression in CD4 T cells, monocytes and macrophages. We will also engineer similar CD8 aptamer-siRNA chimeras for gene knockdown in CD8 T cells and NK cells...
- Neuroprotection by IFN-beta in AIDSMarcus Kaul; Fiscal Year: 2013..neurodegeneration occurs as a consequence of HIV-1 infection and neurotoxic immune stimulation of microglia and macrophages (M?) in the brain and impairment of neurogenesis...
- Maternal Autoantibodies: Pathogenesis of Neonatal LupusJILL PAMELA BUYON; Fiscal Year: 2013..Understanding the mechanism by which these autoantibodies cause cardiac scarring is critical to the development of strategies for treatment or prevention of this condition, known as congenital heart block. ..
- Mechanisms of Angiogenesis of Retinopathy of PrematurityMARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013..We will study the effects of EC-derived NADPH oxidase by depleting animals of macrophages. To change the degree of activation of NADPH oxidase, we will also use the 50/10 OIR model rescued in hyperoxia ..
- Colitis Induced by immune responses to luminal bacteria-mouseRyan B Sartor; Fiscal Year: 2012..epithelial cell adherence, invasion and resistance to intracellular killing within epithelial cells and macrophages, or 2) Genetically determined host innate defects in bacterial killing and mucosal barrier function...
- Deregulated lipid metabolism in strokeRobert J Dempsey; Fiscal Year: 2013..the cell cycle after stroke will provide benefit by attenuating neuronal death and proliferation of microglia/macrophages. Cell cycle regulation by lipid second messengers after stroke: Sphingomyelin (SM) synthase (SMS) transfers ..
- Impact of Diabetes and Hyperlipidemia on Host DefenseHardy Kornfeld; Fiscal Year: 2013..Diabetic mice are slow to develop aggregates of myeloid cells around Mtb-infected alveolar macrophages (AMF) and slow to deliver bacilli to the thoracic lymph nodes (TLN) where immunity is primed...
- Immune Development: Role of Milk Cell Transfer and Recipient GenderAmeae M Walker; Fiscal Year: 2013..Despite high numbers of GFP+ B cells and macrophages in milk, these cells were not observed undergoing trans-epithelial migration...
- Immune modulators of inflammation in servere COPDFarrah Kheradmand; Fiscal Year: 2010..We and others have shown that in addition to macrophages and neutrophils, lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, ..
- Lipid Binding Proteins in Obesity and Diabetes SyndromesDavid A Bernlohr; Fiscal Year: 2011..proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages. FABPs bind a variety of unesterified fatty acids and other lipid second messengers and mediate their ..
- Hypertension and Collagen: Effect of Ac-SDKPNour Eddine Rhaleb; Fiscal Year: 2010..improve the affinity of the radio-iodinated peptide;and 2) characterize the Ac-SDKP receptor in fibroblasts and macrophages (rat and human), using [ l]-Hpp- Aca-SDKP and newly developed antagonists;and 3) compare rat cardiac ..
- DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosisRuslana Bryk; Fiscal Year: 2012..regulator by studying DlaT's expression under different conditions in vitro, in mouse bone marrow macrophages and in mice, by identifying proteins associating with DlaT under those conditions, by producing deletion and ..
- Mechanism of Irradiation Pulmonary FibrosisJoel S Greenberger; Fiscal Year: 2012..We have demonstrated that bone marrow origin macrophages migrate to the mouse lung at the time of up regulation of endothelial cell VCAM-1 and ICAM-1 at 120-140 days ..
- SRP RNA level as a determinant of leishmanial parasitism of macrophagesGautam Chaudhuri; Fiscal Year: 2009DESCRIPTION (provided by applicant): Leishmania is a group of parasitic protozoa that infect human macrophages and thrive inside the hostile environment of the phagolysosomes of these cells...
- A gene therapy for bacterial translocation in mice with whole body irradiationFujio Suzuki; Fiscal Year: 2010DESCRIPTION (provided by applicant): In studies of severely burned mice, IL-10(-) IL-12(+) macrophages (M1 macrophages) distributed in lamina propria (LP) and mesenteric lymph nodes (MLN) have been identified as major effector cells in ..
- THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSISWilliam Boisvert; Fiscal Year: 2002..in vitro is attenuated by several inflammatory mediators which can be in the plaque, or by differentiation to macrophages. They therefore propose that other mechanisms are at play in promoting macrophage retention and expansion ..
- M. tuberculosis survival in MacrophagesRichard Friedman; Fiscal Year: 2003..by the applicant): Central to the disease process in tuberculosis are the interactions of the bacilli with host macrophages. The infection of macrophages by Mycobacterium tuberculosis can be divided into four steps: adherence, entry, ..
- Role(s) of VEGF in Resolution of InflammationManuela M Martins Green; Fiscal Year: 2010..Upon wounding, cytokines are activated and chemoattract leukocytes, including macrophages, to the wound site...
- REGULATION OF THE TUMORICIDAL MACROPHAGE PHENOTYPEDavid Riches; Fiscal Year: 1991..As such, macrophage activation represents an important limb of the host defence system. Monocyte derived macrophages are initially primed by exposure to IFN alpha, beta, or gamma...
- Aveolar Macrophage Apoptosis and PneumocystisChao Hung Lee; Fiscal Year: 2009..The number of alveolar macrophages is decreased in humans with Pneumocystis pneumonia (Pep)...
- PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSISCECIL LYTTLE; Fiscal Year: 1993..indicated that the peritoneal fluid of women with endometriosis contains approximately ten times the number of macrophages as is seen in the disease free fertile patient...
- Novel GPCR Kinase Interactions in Macrophages and Role in ArthritisNarayanan Parameswaran; Fiscal Year: 2009Monocytes/macrophages are crucial cell types in inflammatory processes in many diseases including musculoskeletal diseases...
- GM-CSF is required for macrophage surfactant catabolismTracey Bonfield; Fiscal Year: 2006..in the alveoli of surfactant material, which is thought to result from inefficient catabolism by alveolar macrophages and type II epithelial cells...
- IL15 AND NATURAL KILLER (NK) CELL FUNCTIONWilliam Carson; Fiscal Year: 1999We hypothesize that macrophages are able to influence the function of natural killer (NK) cells via a novel cytokine known as IL-15...
- DECIDUAL CELL/PLACENTAL INTERACTIONSJOAN HUNT; Fiscal Year: 1993..Among the major cell types that expand in response to pregnancy are macrophages, cells with both primitive and highly sophisticated functions...