heart mitochondria

Summary

Summary: The mitochondria of the myocardium.

Top Publications

  1. ncbi Supercomplexes in the respiratory chains of yeast and mammalian mitochondria
    H Schagger
    Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, D 60590 Frankfurt, Germany
    EMBO J 19:1777-83. 2000
  2. ncbi Calpain inhibitor (BSF 409425) diminishes ischemia/reperfusion-induced damage of rabbit heart mitochondria
    Sonata Trumbeckaite
    , , D-06097 Halle/Saale, Germany
    Biochem Pharmacol 65:911-6. 2003
  3. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
  4. ncbi Sevoflurane preconditioning limits intracellular/mitochondrial Ca2+ in ischemic newborn myocardium
    Hong Liu
    Department of Anesthesiology and Pain Medicine, University of California Davis Medical Center, 4150 V St, Suite 1200, Sacramento, CA 95817, USA
    Anesth Analg 101:349-55, table of contents. 2005
  5. ncbi Role of glycogen synthase kinase-3beta in cardioprotection
    Magdalena Juhaszova
    Laboratory of Cardiovascular Science, Gerontology Research Center, Box 13, National Institute on Aging, NIH, Baltimore, Maryland 21224 6825, USA
    Circ Res 104:1240-52. 2009
  6. ncbi Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Diabetes 56:2457-66. 2007
  7. ncbi Exercise training induces respiratory substrate-specific decrease in Ca2+-induced permeability transition pore opening in heart mitochondria
    Mariannick Marcil
    , , PO Box 6128 Centre-Ville, Montreal, PQ, Canada H3C 3J7
    Am J Physiol Heart Circ Physiol 290:H1549-57. 2006
  8. ncbi The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria
    Lothar Kussmaul
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 103:7607-12. 2006
  9. ncbi Heart mitochondria: gates of life and death
    Asa B Gustafsson
    BioScience Center San Diego State University 5500 Campanile Drive San Diego, CA 92182 4650, USA
    Cardiovasc Res 77:334-43. 2008
  10. ncbi Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A
    Samantha J Clarke
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:34793-9. 2002

Research Grants

  1. STUDIES OF O2 ACTIVATION BY MOSSBAUER SPECTROSCOPY
    Eckard Munck; Fiscal Year: 1990
  2. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
  3. Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart
    RANJAN K contact DASH; Fiscal Year: 2010
  4. METABOLISM OF UNSATURATED AND HYDROXY FATTY ACIDS
    Horst Schulz; Fiscal Year: 1990
  5. Heart mitochondrial toxicity of antiviral nucleosides
    Edward McKee; Fiscal Year: 2006
  6. ENERGY TRANSDUCING ATPASE
    William Allison; Fiscal Year: 1990
  7. PROTON & ELECTRON TRANSFER & ENERGY COUPLING IN SITE I
    TOMOKO NONE OHNISHI; Fiscal Year: 2010
  8. PROTON & ELECTRON TRANSFER & ENERGY COUPLING IN SITE I
    Tomoko Ohnishi; Fiscal Year: 2009
  9. PROTON & ELECTRON TRANSFER & ENERGY COUPLING IN SITE I
    Tomoko Ohnishi; Fiscal Year: 2007
  10. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2010

Detail Information

Publications250 found, 100 shown here

  1. ncbi Supercomplexes in the respiratory chains of yeast and mammalian mitochondria
    H Schagger
    Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, D 60590 Frankfurt, Germany
    EMBO J 19:1777-83. 2000
    ..A fraction of total bovine ATP synthase (complex V) was isolated in dimeric form, suggesting that a dimeric state is not limited to S.cerevisiae, but also exists in mammalian mitochondria...
  2. ncbi Calpain inhibitor (BSF 409425) diminishes ischemia/reperfusion-induced damage of rabbit heart mitochondria
    Sonata Trumbeckaite
    , , D-06097 Halle/Saale, Germany
    Biochem Pharmacol 65:911-6. 2003
    ..of a new developed calpain inhibitor (CI) BSF 409425 on the ischemia/reperfusion-induced damage of rabbit heart mitochondria was investigated...
  3. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
    ..However, only if subsequent MPTP closure occurs will ATP levels be maintained, ensuring that cell death continues down an apoptotic, rather than a necrotic, pathway...
  4. ncbi Sevoflurane preconditioning limits intracellular/mitochondrial Ca2+ in ischemic newborn myocardium
    Hong Liu
    Department of Anesthesiology and Pain Medicine, University of California Davis Medical Center, 4150 V St, Suite 1200, Sacramento, CA 95817, USA
    Anesth Analg 101:349-55, table of contents. 2005
    ..Mitochondrial K(ATP) channel blockade attenuates the SPC effect during I/R, suggesting that these channels are involved in the protective effects of SPC in the newborn...
  5. ncbi Role of glycogen synthase kinase-3beta in cardioprotection
    Magdalena Juhaszova
    Laboratory of Cardiovascular Science, Gerontology Research Center, Box 13, National Institute on Aging, NIH, Baltimore, Maryland 21224 6825, USA
    Circ Res 104:1240-52. 2009
    ....
  6. ncbi Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Diabetes 56:2457-66. 2007
    ..Mitochondrial uncoupling has been proposed to contribute to these metabolic abnormalities but has not been directly demonstrated...
  7. ncbi Exercise training induces respiratory substrate-specific decrease in Ca2+-induced permeability transition pore opening in heart mitochondria
    Mariannick Marcil
    , , PO Box 6128 Centre-Ville, Montreal, PQ, Canada H3C 3J7
    Am J Physiol Heart Circ Physiol 290:H1549-57. 2006
    ..to determine whether regular exercise (treadmill running, 10 wk) alters the susceptibility of rat isolated heart mitochondria to Ca(2+)-induced permeability transition pore (PTP) opening and whether this could be associated with ..
  8. ncbi The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria
    Lothar Kussmaul
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 103:7607-12. 2006
    ..we describe the kinetic and molecular mechanism of superoxide production by complex I isolated from bovine heart mitochondria and confirm that it produces predominantly superoxide, not hydrogen peroxide...
  9. ncbi Heart mitochondria: gates of life and death
    Asa B Gustafsson
    BioScience Center San Diego State University 5500 Campanile Drive San Diego, CA 92182 4650, USA
    Cardiovasc Res 77:334-43. 2008
    ..In this review, we discuss the role of mitochondria in the control of cell death in cardiac myocytes...
  10. ncbi Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A
    Samantha J Clarke
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:34793-9. 2002
    ..Because SfA does not inhibit calcineurin activity, our data suggest that it may be more desirable than CsA for protecting tissues recovering from ischemic episodes and for studying the role of the MPTP in cell death...
  11. ncbi Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    G C Kujoth
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Science 309:481-4. 2005
    ..The levels of apoptotic markers were also found to increase during aging in normal mice. Thus, accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging...
  12. ncbi Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
    Qun Chen
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Cell Physiol 294:C460-6. 2008
    ..Thus ischemic damage to the ETC increased both the capacity and the net production of H(2)O(2) from complex I and complex III and sets the stage for an increase in ROS production during reperfusion as a mechanism of cardiac injury...
  13. ncbi Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion
    Giancarlo Solaini
    Scuola Superiore di Studi Universitari e di Perfezionamento S. Anna, Classe Accademica di Scienze Sperimentali, , 56127 Pisa, Italy
    Biochem J 390:377-94. 2005
    ..Finally, we summarize the metabolic and pharmacological interventions that have been used to alleviate the effects of ischaemic injury, highlighting the value of these or related interventions in possible therapeutics...
  14. ncbi Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: a short review
    Ernest Adeghate
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Mol Cell Biochem 261:187-91. 2004
    ....
  15. ncbi Identification of a ryanodine receptor in rat heart mitochondria
    G Beutner
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:21482-8. 2001
    ..In the presence of ryanodine, Ca(2+) uptake into isolated heart mitochondria is suppressed. In addition, ryanodine inhibited mitochondrial swelling induced by Ca(2+) overload...
  16. ncbi Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondria
    Connie S Yarian
    Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 330:151-6. 2005
    ..The biological consequences of an age-related decrease in aconitase and ATP synthase activities may contribute to the decline in mitochondrial bioenergetics evident during aging...
  17. ncbi Role of the mitochondrial permeability transition in myocardial disease
    James N Weiss
    Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1760, USA
    Circ Res 93:292-301. 2003
    ..Investigations into this area are beginning to unravel some of the mechanistic links between cardioprotective signaling and mitochondria...
  18. ncbi Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    Diabetes 51:1938-48. 2002
    ..Hyperglycemia-induced myocardial apoptosis is mediated, at least in part, by activation of the cytochrome c-activated caspase-3 pathway, which may be triggered by ROS derived from high levels of glucose...
  19. ncbi The phosphorylation of subunits of complex I from bovine heart mitochondria
    Ruming Chen
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    J Biol Chem 279:26036-45. 2004
    In bovine heart mitochondria and in submitochondrial particles, membrane-associated proteins with apparent molecular masses of 18 and 10 kDa become strongly radiolabeled by [(32)P]ATP in a cAMP-dependent manner...
  20. ncbi Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
    Adrian J Lambert
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Aging Cell 6:607-18. 2007
    ..We investigated this correlation by comparing rates of hydrogen peroxide (H(2)O(2)) production by heart mitochondria isolated from groups or pairs of species selected to have very different maximum lifespans but similar body ..
  21. ncbi The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry
    Chérise D Barker
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Biochemistry 46:3454-64. 2007
    Complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria contains 45 different subunits and nine redox cofactors...
  22. ncbi Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells
    Yvonne Will
    Exploratory Safety Differentiation, Pfizer, Inc, Groton, Connecticut 06340, USA
    Toxicol Sci 106:153-61. 2008
    ..Furthermore, we measured respiratory capacity of isolated rat heart mitochondria in the presence of the four kinase inhibitors and examined their effect on each of the oxidative ..
  23. ncbi Effects of desmin gene knockout on mice heart mitochondria
    M Linden
    Groupe de Biologie des Interactions Cellulaires, UMR CNRS 6558, Poitiers, France
    J Bioenerg Biomembr 33:333-41. 2001
    ..1997). In the present study we have isolated heart mitochondria from desmin null (D-/-) and control (D+/+) mice, and analyzed their composition by SDS-PAGE, immunoblotting, ..
  24. ncbi Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  25. ncbi Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis
    Norbert Nagy
    Cardiovascular Research Center, University of Connecticut, School of Medicine, Farmington, CT 06030 1110, USA
    J Mol Cell Cardiol 44:252-60. 2008
    ..The results indicated a crucial role of mitochondrial Glrx2 in cardioprotection...
  26. ncbi Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation
    V Borutaite
    Institute for Biomedical Research, Kaunas Medical University, Lithuania
    Biochim Biophys Acta 1453:41-8. 1999
    ..and other inducers of mitochondrial permeability transition cause the release of cytochrome c from isolated heart mitochondria. We found that 5 microM free Ca2+ induced changes in oxidative phosphorylation system similar to ischaemic ..
  27. ncbi Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    J J Lehman
    Department of Medicine, and Department of Pathology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 106:847-56. 2000
    ..These results identify PGC-1 as a critical regulatory molecule in the control of cardiac mitochondrial number and function in response to energy demands...
  28. ncbi Bovine complex I is a complex of 45 different subunits
    Joe Carroll
    Dunn Human Nutrition Unit, The Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 281:32724-7. 2006
    ..Thus, the subunit composition of bovine complex I has been established. It is a complex of 45 different proteins plus non-covalently bound FMN and eight iron-sulfur clusters...
  29. ncbi Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart
    Sabzali A Javadov
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 549:513-24. 2003
    ..Our data suggest that protection from reperfusion injury is better achieved by reducing factors that induce MPTP opening than by inhibiting the MPTP directly...
  30. ncbi Effects of NO on mitochondrial function in cardiomyocytes: Pathophysiological relevance
    Sean M Davidson
    The Hatter Cardiovascular Institute, Department of Medicine, Royal Free and University College Medical School, 67 Chenies Mews, University College Hospital, London WC1E 6HX, United Kingdom
    Cardiovasc Res 71:10-21. 2006
    ....
  31. ncbi Role of apoptosis in cardiovascular disease
    Youngil Lee
    BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
    Apoptosis 14:536-48. 2009
    ..This review provides a current overview of the evidence of apoptosis in cardiovascular diseases and discusses the molecular pathways involved in cardiac myocyte apoptosis...
  32. ncbi Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
    Valentina Parra
    Centro FONDAP Estudios Moleculares de la Celula, Universidad de Chile, Olivos 1007, Santiago 8380492, Chile
    Cardiovasc Res 77:387-97. 2008
    ..This process is associated with cell death. We investigated whether activation of apoptosis with ceramides affects mitochondrial dynamics and promotes mitochondrial fission in cardiomyocytes...
  33. ncbi Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long-lived pigeon, Columba livia
    Adrian J Lambert
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK
    Aging Cell 9:78-91. 2010
    ..this report, we investigate the underlying biochemical basis of the low hydrogen peroxide production rate of heart mitochondria from a long-lived species (pigeon) compared with a short-lived species with similar body mass (rat)...
  34. ncbi Potassium-specific effects of levosimendan on heart mitochondria
    Dalia M Kopustinskiene
    Institute for Biomedical Research, Kaunas University of Medicine, Kaunas, Lithuania
    Biochem Pharmacol 68:807-12. 2004
    ..in mitochondrial inner membrane permeability for potassium by registering changes in membrane potential of heart mitochondria, oxidizing endogenous substrates...
  35. ncbi Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy
    Xia Shen
    Department of Pathology, University of Washington, Seattle, USA
    Diabetes 55:798-805. 2006
    ..These results showed that elevating MnSOD provided extensive protection to diabetic mitochondria and provided overall protection to the diabetic heart...
  36. ncbi Determination of the oxidation states of manganese in brain, liver, and heart mitochondria
    Thomas E Gunter
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurochem 88:266-80. 2004
    ..While the presence of Mn3+ complexes cannot be proven in the spectrum of endogenous mitochondrial manganese, the shape of this spectrum could suggest the presence of Mn3+ near the limit of detection, probably as MnSOD...
  37. ncbi Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria
    Guangyin Zhou
    Laboratory of Visual Information Processing, Department of Molecular and Cell Biophysics, Institute of Biophysics, Academia Sinica, Beijing 100101, PR China
    Biochem Pharmacol 65:51-7. 2003
    ..paper, an electron transfer reaction mediated by sodium tanshinone IIA sulfonate (STS) was studied in rat heart mitochondria. It was found that STS could stimulate mitochondrial NADH oxidation dose-dependently and partly restore NADH ..
  38. ncbi Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes
    Duncan H F Mak
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Phytother Res 20:561-7. 2006
    ..The measurement of RBC glutathione status may serve as a useful index for the antioxidant effect produced by DBT treatment in human subjects...
  39. ncbi Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1 receptor activation
    T Miura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    J Am Coll Cardiol 35:238-45. 2000
    ..This study intended to assess the role of mitochondrial ATP-sensitive potassium (mitoK ATP) channels and the sequence of signal transduction with protein kinase C (PKC) and adenosine A1 receptors in rabbits...
  40. ncbi Effects of thyroid state on H2O2 production by rat heart mitochondria: sites of production with complex I- and complex II-linked substrates
    P Venditti
    Dipartimento di Fisiologia Generale ed Ambientale, , Italy
    Horm Metab Res 35:55-61. 2003
    ..to determine possible effects of altered thyroid states on rates and sites of H 2 O 2 production by rat heart mitochondria. Rates of O 2 consumption and H 2 O 2 release, capacities to remove the peroxide, lipid peroxidation, ..
  41. ncbi Seasonal variations in properties of healthy and diabetic rat heart mitochondria: Mg2+-ATPase activity, content of conjugated dienes and membrane fluidity
    J Mujkosová
    Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovakia
    Physiol Res 57:S75-82. 2008
    Our previous preliminary results pointed to possible seasonal variations in Mg2+-ATPase activity of rat heart mitochondria (MIT)...
  42. ncbi Pharmacological and physiological stimuli do not promote Ca(2+)-sensitive K+ channel activity in isolated heart mitochondria
    Douglas V Cancherini
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Cardiovasc Res 73:720-8. 2007
    ..NS-1619 is cardioprotective, leading to the assumption that this effect is related to the opening of mitoK(Ca) channels. Here, we show several weaknesses in this hypothesis...
  43. ncbi Investigation of the mechanism of proton translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism?
    Steven Sherwood
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 400:541-50. 2006
    ..Here, we describe experiments to determine whether complex I, isolated from bovine heart mitochondria, operates via a Q-cycle mechanism analogous to that observed in the cytochrome bc1 complex...
  44. ncbi The amino acid sequence of GTP:AMP phosphotransferase from beef-heart mitochondria. Extensive homology with cytosolic adenylate kinase
    B Wieland
    Eur J Biochem 143:331-9. 1984
    The amino acid sequence of GTP:AMP phosphotransferase (AK3) from beef-heart mitochondria has been determined, except for one segment of about 33 residues in the middle of the polypeptide chain...
  45. ncbi Regucalcin increases Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats
    Tania Akhter
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 18:171-6. 2006
    ..a regulatory protein in intracellular signaling system, in the regulation of Ca2+-ATPase activity in rat heart mitochondria was investigated...
  46. ncbi Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria
    A D Vinogradov
    Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow 119992, Russia
    Biochemistry (Mosc) 70:120-7. 2005
    ..One site (F) serves as an entry for the NADH oxidation and the other one (R) serves as an exit during either the succinate-supported NAD+ reduction or superoxide generation or NADH-ferricyanide reductase reaction...
  47. ncbi Failure to precondition pathological human myocardium
    S Ghosh
    Department of Surgery, University Hospitals Leicester, United Kingdom
    J Am Coll Cardiol 37:711-8. 2001
    ....
  48. ncbi Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes
    Xia Shen
    Dept. of Pharmacology and Toxicology, University of Louisville, 570 S. Preston St, Suite 304, Louisville, KY 40202, USA
    Am J Physiol Endocrinol Metab 287:E896-905. 2004
    ..Taken together, these results show that mitochondria are a primary target in the diabetic heart, probably due to oxidative stress, and that this damage coincides with and may stimulate mitochondrial biogenesis...
  49. ncbi Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    J Am Coll Cardiol 48:1688-97. 2006
    ..We aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy...
  50. ncbi Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole
    Fabio Di Lisa
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, 35121 Padova
    Cardiovasc Res 70:191-9. 2006
    ..Here, we discuss our current understanding of the structure and function of PTP in the context of heart injury caused by ischemia and reperfusion...
  51. ncbi Postconditioning prevents reperfusion injury by activating delta-opioid receptors
    Youngho Jang
    Department of Anesthesiology, The University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Anesthesiology 108:243-50. 2008
    ..The authors hypothesized that postconditioning stimulates opioid receptors, which in turn protect the heart from reperfusion injury by targeting the mPTP...
  52. ncbi Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria
    Ivan Spasojevic
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 42:1193-200. 2007
    ..55:39-46; 1979). We found MnIIITE-2-PyP5+ localized in heart mitochondria to 2.95 ng/mg protein. Given the average value of mitochondrial volume of 0...
  53. ncbi Mitochondrial potassium transport: the K(+) cycle
    Keith D Garlid
    Department of Biology, Portland State University, 1719 SW 10th Avenue, PO Box 751, Portland, OR 97207, USA
    Biochim Biophys Acta 1606:23-41. 2003
    ..This review discusses the properties of the mitochondrial K(+) cycle that help to understand the basis of these diverse effects...
  54. ncbi Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling
    Thomas R Hurd
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge, UK
    J Biol Chem 282:22040-51. 2007
    ..Thiol redox modification affected enzyme activity, suggesting that the reversible modification of enzyme activity by ROS from the respiratory chain may be an important and unexplored mode of mitochondrial redox signaling...
  55. ncbi Cardioprotective signaling to mitochondria
    Keith D Garlid
    Department of Biology, Portland State University, Portland, OR 97201 0751, USA
    J Mol Cell Cardiol 46:858-66. 2009
    ..We review the experimental findings that bear on these hypotheses and other modes of protection involving mitochondria...
  56. ncbi K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart
    Peter J Hanley
    , , Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 542:735-41. 2002
    ..We propose that pharmacological preconditioning may be related to partial inhibition of respiratory chain complexes...
  57. ncbi Postconditioning inhibits mitochondrial permeability transition
    Laurent Argaud
    INSERM E 0226, , France
    Circulation 111:194-7. 2005
    ..05). CONCLUSIONS: Postconditioning inhibits opening of the mPTP and provides a powerful antiischemic protection...
  58. ncbi Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat
    Dario Loureiro Santos
    , Vila Real, Portugal
    Mol Cell Biochem 246:163-70. 2003
    ..In terms of lipid peroxidation the oxidative damage was evaluated on heart mitochondria by measuring both the O2 consumption and the concentrations of thiobarbituric acid reactive substances...
  59. ncbi Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 332:853-8. 2005
    ..The m-aconitase, not the cytosolic aconitase (c-aconitase), was co-immunoprecipitated with MT. This study demonstrates that MT transfers zinc to m-aconitase through a direct interaction...
  60. ncbi Analysis of the subunit composition of complex I from bovine heart mitochondria
    Joe Carroll
    Medical Research Council Dunn Human Nutrition Unit, The Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    Mol Cell Proteomics 2:117-26. 2003
    Complex I purified from bovine heart mitochondria is a multisubunit membrane-bound assembly. In the past, seven of its subunits were shown to be products of the mitochondrial genome, and 35 nuclear encoded subunits were identified...
  61. ncbi Temperature preconditioning of isolated rat hearts--a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore
    Igor Khaliulin
    Department of Biochemistry, Bristol Heart Institute, University of Bristol, UK
    J Physiol 581:1147-61. 2007
    ..The presence of N-(2-mercaptopropionyl) glycine during TP also abolished cardioprotection, indicating an involvement of free radicals in the signalling mechanism...
  62. ncbi Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K(+) channel in cardiac function and cardioprotection
    Keith D Garlid
    Department of Biology, Portland State University, 1719 SW 10th Avenue, PO Box 751, Portland, OR 97207, USA
    Biochim Biophys Acta 1606:1-21. 2003
    ..MitoK(ATP)-mediated volume regulation, in turn, prevents disruption of the structure-function of the IMS and facilitates efficient energy transfers between mitochondria and myofibrillar ATPases...
  63. ncbi Time course of differential mitochondrial energy metabolism adaptation to chronic hypoxia in right and left ventricles
    Karine Nouette-Gaulain
    , E.A. Physiologie Mitochondriale, , 33076 Bordeaux Cedex, France
    Cardiovasc Res 66:132-40. 2005
    ..CONCLUSIONS: CH alters morphometry and function of mitochondria in the heart, but this effect is delayed in the right compared to the left ventricle, suggesting some adaptive processes at the onset of right ventricular hypertrophy...
  64. ncbi Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria
    Alexandre D T Costa
    Department of Biology, Portland State University, Portland, Ore, USA
    Circ Res 97:329-36. 2005
    ..We conclude PKG is the terminal cytosolic component of the trigger pathway; it transmits the cardioprotective signal from cytosol to inner mitochondrial membrane by a pathway that includes PKC-epsilon...
  65. ncbi Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria
    Qun Chen
    Dept of Medicine, Cardiology Section, Medical Service 111 W, Case Western Reserve University, Louis Stokes Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA
    J Pharmacol Exp Ther 316:200-7. 2006
    ..5 mM. Amobarbital also preserved cytochrome c content in both SSM and IFM. Thus, reversible blockade of the electron transport chain during ischemia protects mitochondrial respiration...
  66. ncbi Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization
    Gyorgy Hajnoczky
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 29:693-701. 2005
    ..This article discusses potential mechanisms of the effect of alcohol on mitochondrial membrane permeabilization and visualization of mitochondria-dependent apoptosis in cardiac muscle...
  67. ncbi Mitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A
    Toshiaki Sato
    Department of Pharmacology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Circulation 111:198-203. 2005
    ..However, questions about the cardioprotective mechanism and the kinase-mediated regulation of mitoK(Ca) channels remain to be answered...
  68. ncbi 5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids
    Peter J Hanley
    Institut fur Normale und Pathologische Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 562:307-18. 2005
    ..using specially synthesised (and purified) substrates and enzymes, as well as isolated rat liver and heart mitochondria, and compared it with the metabolism of the physiological substrate decanoyl-CoA...
  69. ncbi Architecture of active mammalian respiratory chain supercomplexes
    Eva Schäfer
    Department of Chemistry, Physical Biochemistry, Darmstadt University of Technology, Petersenstrasse 22, D 64287 Darmstadt, Germany
    J Biol Chem 281:15370-5. 2006
    ..microscopic characterization of the two respiratory chain supercomplexes I1III2 and I1III2IV1 in bovine heart mitochondria, which are also two major supercomplexes in human mitochondria...
  70. ncbi FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation
    Jonathan P Brennan
    Cardiac Physiology (Cardiovascular Division, King's College London, SE1 7EH, UK
    Cardiovasc Res 72:322-30. 2006
    ..This establishes the principle that mild mitochondrial uncoupling activates a protective mechanism. Diazoxide did not cause mitochondrial oxidation or mitochondrial depolarisation, suggesting it induces protection via another mechanism...
  71. ncbi The inhibition of mitochondrial complex I (NADH:ubiquinone oxidoreductase) by Zn2+
    Mark S Sharpley
    Medical Research Council (MRC) Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 2XY, United Kingdom
    J Biol Chem 281:34803-9. 2006
    NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria is a highly complicated, membrane-bound enzyme...
  72. ncbi Modular regulation analysis of heart contraction: application to in situ demonstration of a direct mitochondrial activation by calcium in beating heart
    Philippe Diolez
    Résonance Magnétique des Systèmes Biologiques, UMR5536 CNRS Université Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Am J Physiol Regul Integr Comp Physiol 293:R13-9. 2007
    ....
  73. ncbi DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity
    Shiwei Song
    Department of Biochemistry and Biophysics, Oregon State University, 2011 ALS, Corvallis, OR 97331 7305, USA
    Proc Natl Acad Sci U S A 102:4990-5. 2005
    ....
  74. ncbi Reduced mitochondrial DNA transcription in senescent rat heart
    A L Andreu
    Centre d Investigacions en Bioquímica i Biologia Molecular dels Hospitals Vall d Hebrón, P Vall d Hebrón 119 125, Barcelona, E 08035, Spain
    Biochem Biophys Res Commun 252:577-81. 1998
    ..senescence on mitochondrial DNA (mtDNA) transcription with an in organello system using intact isolated rat heart mitochondria. A comparison of the electrophoretic patterns of mtDNA transcription products in young, adult and senescent ..
  75. ncbi Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase
    I R Collinson
    MRC Laboratory of Molecular Biology, Cambridge, U K
    Biochemistry 33:7971-8. 1994
    The Fo membrane domain of the F1Fo-ATP synthase complex has been purified from bovine heart mitochondria. The purification procedure involves the removal of peripheral membrane proteins, including F1-ATPase, from submitochondrial ..
  76. ncbi Mitochondrial K(ATP) channels: role in cardioprotection
    Olaf Oldenburg
    Department of Physiology, MSB 3024, University of South Alabama, College of Medicine, Mobile 36688, USA
    Cardiovasc Res 55:429-37. 2002
    ..Thus the mK(ATP) probably serves a dual role as both a trigger and a mediator. Possible end-effectors of preconditioning's protection are discussed including the mK(ATP) itself...
  77. ncbi Mitochondrial ATPase and high-energy phosphates in failing hearts
    J Liu
    Department of Medicine, University of Minnesota Health Sciences, Minneapolis, Minnesota 55455, USA
    Am J Physiol Heart Circ Physiol 281:H1319-26. 2001
    ..Thus in failing hearts, reductions in mitochondrial F(0)F(1)-ATPase protein expression are associated with increased myocardial free ADP...
  78. ncbi Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase
    Chwen Lih Chen
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 46:5754-65. 2007
    ..The result also implies that S-glutathiolation of the 75 kDa subunit may play a role in protecting the 4Fe-4S cluster of the 51 kDa subunit from redox modification when complex I is exposed to redox change in the GSH pool...
  79. ncbi Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits
    Joe Carroll
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 277:50311-7. 2002
    ..Subunit ESSS has a cleaved mitochondrial import sequence and one potential transmembrane helix. A total of 45 different subunits of bovine complex I have now been characterized...
  80. ncbi Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target
    Bin Liu
    Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA
    Biochim Biophys Acta 1794:476-85. 2009
    ..Selective nitration of proteins from the oxidative phosphorylation system at the beginning of reperfusion may contribute to the suppression of oxygen consumption...
  81. ncbi Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heart
    Tetsuji Shinohara
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Am J Physiol Heart Circ Physiol 293:H1892-9. 2007
    ..These processes may involve opening of the mitoK(ATP) channel...
  82. ncbi Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection
    Christopher P Baines
    Department of Physiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Circ Res 90:390-7. 2002
    ..Furthermore, formation of mitochondrial PKCepsilon-ERK modules appears to play a role in PKCepsilon-mediated cardioprotection, in part by the phosphorylation and inactivation of Bad...
  83. ncbi Role of mitochondrial re-energization and Ca2+ influx in reperfusion injury of metabolically inhibited cardiac myocytes
    Glenn C Rodrigo
    Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    Cardiovasc Res 67:291-300. 2005
    ..We used isolated myocytes to investigate the role of mitochondrial re-energization and Ca2+ influx during reperfusion on hypercontracture, loss of Ca2+ homeostasis and contractile function...
  84. ncbi Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression
    Courtney L Williamson
    West Virginia University School of Medicine, Division of Exercise Physiology, Center for Interdisciplinary Research in Cardiovascular Sciences, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Am J Physiol Heart Circ Physiol 294:H249-56. 2008
    ....
  85. ncbi Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation
    Jonathan P Brennan
    Cardiac Physiology (Cardiovascular Division, The Rayne Institute, St Thomas' Hospital, King's College London, SE1 7EH, UK
    Cardiovasc Res 72:313-21. 2006
    ..This cardioprotection is not mediated via the depletion of cellular ATP or mitochondrial K(ATP) channel activation...
  86. ncbi Effect of T3 treatment on the response to ischemia-reperfusion of heart preparations from sedentary and trained rats
    Paola Venditti
    Dipartimento delle Scienze Biologiche, Sezione di Fisiologia, Universita Federico II di Napoli, V Mezzocannone 8, I80134 Naples, Italy
    Pflugers Arch 455:667-76. 2008
    ..The above results suggest that moderate training is able to reduce hyperthyroid heart susceptibility to oxidative damage and dysfunction modifying mitochondrial population...
  87. ncbi The role of mitochondria in protection of the heart by preconditioning
    Andrew P Halestrap
    Department of Biochemistry and Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochim Biophys Acta 1767:1007-31. 2007
    ..This phase of protection may involve survival kinase pathways such as Akt and glycogen synthase kinase 3 (GSK3) either increasing ROS removal or reducing mitochondrial ROS production...
  88. ncbi Cardioprotection by K(ATP) channels in wild-type hearts and hearts overexpressing A(1)-adenosine receptors
    J P Headrick
    The Rotary Centre for Cardiovascular Research, Griffith University Gold Coast Campus, Southport, QLD 4217 Australia
    Am J Physiol Heart Circ Physiol 279:H1690-7. 2000
    ..This functional protection occurs without modification of ischemic contracture. The data also support a role for mitochondrial K(ATP) channel activation in the pronounced cardioprotection afforded by overexpression of myocardial A(1)ARs...
  89. ncbi Mitochondrial membrane fluidity, potential, and calcium transients in the myocardium from acute diabetic rats
    Iveta Waczulikova
    Department of Nuclear Physics and Biophysics, Division of Biomedical Physics, Faculty of Mathematics, Physics, and Informatics, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovak Republic
    Can J Physiol Pharmacol 85:372-81. 2007
    ..time concurrent measurements of membrane potential and dynamics and respiratory chain activities in rat heart mitochondria, as well as calcium transients in the hearts of rats in an early phase of streptozotocin diabetes, not yet ..
  90. ncbi Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?
    E Kevelaitis
    Department of Physiology, Kaunas University of Medicine, Kaunas, Lithuania
    J Thorac Cardiovasc Surg 121:155-62. 2001
    ....
  91. ncbi Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane
    Fikret Er
    Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Circulation 110:3100-7. 2004
    ..Endogenous testosterone might play a more important role in recovery after myocardial infarction than is currently assumed...
  92. ncbi Attenuation of mitochondrial, but not cytosolic, Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion
    Chun-Mei Cao
    The Institute of Molecular Medicine, Peking University, Beijing 100871, China
    Acta Pharmacol Sin 27:911-8. 2006
    ..We also confirmed the previous observation that attenuation of [Ca2+]m, but not [Ca2+]c, by ruthenium red improves contractile recovery following ischemia/reperfusion...
  93. ncbi Isoflurane preconditioning protects against ischemia-reperfusion injury partly by attenuating cytochrome c release from subsarcolemmal mitochondria in isolated rat hearts
    Li-Ping Qian
    Jiangsu Provincial Key Lab of Anesthesiology, Jiangsu Institute of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China
    Acta Pharmacol Sin 26:813-20. 2005
    ..5% and 1.0% concentrations of isoflurane. CONCLUSION: Myocardioprotective effects of isoflurane preconditioning were associated with attenuation of cytochrome c loss from the inner membrane of subsarcolemmal mitochondria...
  94. ncbi Mitochondrial genome involvement in ischemia/reperfusion-induced adaptive changes in human myocardial cells
    G C Corbucci
    Departement of Anesthesia and Resuscitation University of Cagliari, Cagliari, Italy
    Minerva Anestesiol 72:337-47. 2006
    ..OX) and mitochondrial encoded subunit 2 expression. Aim of the study was to investigate specific stages of the biochemical and molecular cascade which takes place in cytoprotective mechanisms of ischemic and reperfused cardiac cell...
  95. ncbi Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA
    Am J Hypertens 21:570-5. 2008
    ....
  96. ncbi Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects
    C C T Smith
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, UK
    Br J Pharmacol 149:5-13. 2006
    ..CONCLUSIONS AND IMPLICATIONS: Our data indicate for the first time that the adipocytokine, leptin, has direct cardioprotective properties which may involve the PI3-Akt and p44/42 MAPK pathways...
  97. ncbi Inhibition of mitochondrial permeability transition pore opening by ischemic preconditioning is probably mediated by reduction of oxidative stress rather than mitochondrial protein phosphorylation
    Samantha J Clarke
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, United Kingdom
    Circ Res 102:1082-90. 2008
    ..The signaling pathways mediating this effect and maintaining it during reperfusion are discussed...
  98. ncbi Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1
    Nina C Weber
    Department of Anaesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Pharmacol 539:1-9. 2006
    ..5-hydroxydecanoate and Wortmannin blocked both effects. PKC-epsilon is activated downstream of mitochondrial K(ATP) channels and PDK-1. Both pathways are functionally involved in xenon preconditioning...
  99. ncbi Ischemic preconditioning or p38 MAP kinase inhibition attenuates myocardial TNF alpha production and mitochondria damage in brief myocardial ischemia
    Hiroko Kimura
    Department of Forensic Medicine, Juntendo University School of Medicine, Hongo 2-1-1, Tokyo 113-8421, Japan
    Life Sci 78:1901-10. 2006
    ..This is the first demonstration of the TNF alpha up-regulation in membrane structures of ischemic cardiomyocyte through p38 MAP kinase-mediated post-transcriptional mechanism, in association with mitochondrial damage...
  100. ncbi Brief antecedent anoxia preserves mitochondrial function after sustained undersupply: a subcellular correlate to ischemic preconditioning?
    Sven Y Vetter
    Medizinische Universitätsklinik Ludolf Krehl Klinik, Abteilung Innere Medizin III Schwerpunkt Kardiologie, Angiologie und Pulmologie, Im Neuenheimer Feld 410, D 69120, Heidelberg, Germany
    Mol Cell Biochem 285:191-6. 2006
    ..In addition, we tested whether this protection depends on mitochondrial ATP-dependent potassium channels (K (ATP)) and an might involve an attenuation of mitochondrial ATP hydrolysis during sustained anoxia...
  101. ncbi The mitochondrial origin of postischemic arrhythmias
    Fadi G Akar
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 210205, USA
    J Clin Invest 115:3527-35. 2005
    ....

Research Grants67

  1. STUDIES OF O2 ACTIVATION BY MOSSBAUER SPECTROSCOPY
    Eckard Munck; Fiscal Year: 1990
    ..The a3-site of the enzyme, the locus of oxygen reduction, will be studied with enzymes isolated from beef heart mitochondria, Thermus thermophilus and Nitrosomonas europeae...
  2. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
    ..production will also be studied using the proposed microxymetry; (ii) to study the respiration of isolated heart mitochondria using the proposed microxymtery...
  3. Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart
    RANJAN K contact DASH; Fiscal Year: 2010
    ..g., cation channel blockers or openers) to alleviate mitochondrial dysfunction and preserve cellular viability. ..
  4. METABOLISM OF UNSATURATED AND HYDROXY FATTY ACIDS
    Horst Schulz; Fiscal Year: 1990
    ..between the rates of oxidation of cis and trans unsaturated fatty acids will be determined with rat heart mitochondria. The oxidation of hydroxy fatty acids including 5-hydroxy-6,8,11,13-eicosatetraenoic acid (5-HETE) in ..
  5. Heart mitochondrial toxicity of antiviral nucleosides
    Edward McKee; Fiscal Year: 2006
    ..the HAART components, AZT (Zidovudine) is converted slowly only to AZT-MP and no further, in both isolated heart mitochondria and in the isolated perfused rat heart under conditions in which labeled thymidine is readily converted to ..
  6. ENERGY TRANSDUCING ATPASE
    William Allison; Fiscal Year: 1990
    ..these goals, chemical modification studies are being conducted in parallel on the F1-ATPases from bovine heart mitochondria (MF1), the plasma membrane of E...
  7. PROTON & ELECTRON TRANSFER & ENERGY COUPLING IN SITE I
    TOMOKO NONE OHNISHI; Fiscal Year: 2010
    ..Complex I is the major site of superoxide generation in brain and heart mitochondria, but no consensus has been attained regarding the generation site(s)...
  8. PROTON & ELECTRON TRANSFER & ENERGY COUPLING IN SITE I
    Tomoko Ohnishi; Fiscal Year: 2009
    ..Complex I is the major site of superoxide generation in brain and heart mitochondria, but no consensus has been attained regarding the generation site(s)...
  9. PROTON & ELECTRON TRANSFER & ENERGY COUPLING IN SITE I
    Tomoko Ohnishi; Fiscal Year: 2007
    ..Complex I is the major site of superoxide generation in brain and heart mitochondria, but no consensus has been attained regarding the generation site(s)...
  10. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2010
    ..a newly created panel of SUR2 antibodies and discovered novel short variants (Kd120, 68, 55, 28) in mouse heart mitochondria, with the SUR2-55 form uniquely in mitochondria and not the surface...
  11. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan Makielski; Fiscal Year: 2009
    ..a newly created panel of SUR2 antibodies and discovered novel short variants (Kd120, 68, 55, 28) in mouse heart mitochondria, with the SUR2-55 form uniquely in mitochondria and not the surface...
  12. MITOCHONDRIA AND PULMONARY ENDOTHELIAL CELL DEATH
    James Peterson; Fiscal Year: 2003
    ..electron paramagnetic resonance spectroscopy and magnetic circular and linear dichroism in isolated bovine heart mitochondria and voltage sensitive dyes in intact bovine pulmonary artery endothelial cells, will provide mechanistic ..
  13. STUDIES OF ATP SYNTHETASE FROM HEART MITOCHONDRIA
    Roderick Capaldi; Fiscal Year: 1980
    The ATP synthetase of heart mitochondria is a multicomponent complex which functions in electron transport driven ATP synthesis and as an ATPase to drive ion transport or reverse electron transport...