organelles

Summary

Summary: Specific particles of membrane-bound organized living substances present in eukaryotic cells, such as the MITOCHONDRIA; the GOLGI APPARATUS; ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.

Top Publications

  1. ncbi Morphometric and ultrastructural characterization of Bos indicus preantral follicles
    Mirella Avila Kacinskis
    Department of Cellular Biology, Institute of Biological Science, , , DF 70910-900, Brazil
    Anim Reprod Sci 87:45-57. 2005
  2. ncbi Lipid droplets: a unified view of a dynamic organelle
    Sally Martin
    Institute for Molecular Bioscience, and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia
    Nat Rev Mol Cell Biol 7:373-8. 2006
  3. ncbi Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
    Jeremy N Timmis
    School of Molecular and Biomedical Science, The University of Adelaide, South Australia 5005, Australia
    Nat Rev Genet 5:123-35. 2004
  4. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
  5. ncbi Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles
    David L Alexander
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Pathog 1:e17. 2005
  6. ncbi Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    K Stamer
    Max-Planck-Unit for Structural Molecular Biology, 22607 Hamburg, Germany
    J Cell Biol 156:1051-63. 2002
  7. ncbi Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
  8. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host-Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  9. ncbi Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii
    Sethu C Nair
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Exp Med 208:1547-59. 2011
  10. ncbi Adenine nucleotide transporters in organelles: novel genes and functions
    Javier Traba
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa UAM CSIC, CIBER de Enfermedades Raras, Universidad Autonoma de Madrid, Madrid, Spain
    Cell Mol Life Sci 68:1183-206. 2011

Research Grants

  1. Oocyte polarity and mRNA localization in Zebrafish
    FLORENCE LOUISE MARLOW; Fiscal Year: 2010
  2. REGULATION OF GLYCOSOMAL BIOGENESIS IN T. BRUCEI
    C Wang; Fiscal Year: 1993
  3. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007
  4. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
  5. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
  6. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2010
  7. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok Saluja; Fiscal Year: 2009
  8. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2010
  9. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2010
  10. Hermansky Pudlak Syndrome & melanosome formation
    GRACA GRACA RAPOSO; Fiscal Year: 2010

Detail Information

Publications292 found, 100 shown here

  1. ncbi Morphometric and ultrastructural characterization of Bos indicus preantral follicles
    Mirella Avila Kacinskis
    Department of Cellular Biology, Institute of Biological Science, , , DF 70910-900, Brazil
    Anim Reprod Sci 87:45-57. 2005
    ..The oocyte contained a large and usually eccentric nucleus. Most organelles were located at the perinuclear ooplasm...
  2. ncbi Lipid droplets: a unified view of a dynamic organelle
    Sally Martin
    Institute for Molecular Bioscience, and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia
    Nat Rev Mol Cell Biol 7:373-8. 2006
    ..seem to be able to generate lipid droplets, their biogenesis, regulatory mechanisms and interactions with other organelles remain largely elusive...
  3. ncbi Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
    Jeremy N Timmis
    School of Molecular and Biomedical Science, The University of Adelaide, South Australia 5005, Australia
    Nat Rev Genet 5:123-35. 2004
  4. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  5. ncbi Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles
    David L Alexander
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Pathog 1:e17. 2005
    ..this process, apical membrane antigen 1 (AMA1) is released onto the parasite surface from specialized secretory organelles called micronemes. The T...
  6. ncbi Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    K Stamer
    Max-Planck-Unit for Structural Molecular Biology, 22607 Hamburg, Germany
    J Cell Biol 156:1051-63. 2002
    We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells...
  7. ncbi Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    ..Parasite proteins that bind erythrocyte receptors during invasion are localized in apical organelles called micronemes and rhoptries...
  8. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host-Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  9. ncbi Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii
    Sethu C Nair
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Exp Med 208:1547-59. 2011
    ..We propose that the varied extent of metabolite exchange between host and parasite is a crucial determinator of drug susceptibility and a predictor of future resistance...
  10. ncbi Adenine nucleotide transporters in organelles: novel genes and functions
    Javier Traba
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa UAM CSIC, CIBER de Enfermedades Raras, Universidad Autonoma de Madrid, Madrid, Spain
    Cell Mol Life Sci 68:1183-206. 2011
    ..This work reviews the carriers that transport adenine nucleotides into the organelles of eukaryotic cells together with their possible functions...
  11. ncbi Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    Masaaki Komatsu
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 169:425-34. 2005
    ..autophagosome formation, amino acid supply in neonates, and starvation-induced bulk degradation of proteins and organelles in mice...
  12. ncbi The biogenesis and functions of exosomes
    Willem Stoorvogel
    Department of Cell Biology, Institute of Biomembranes and Centre for Biomedical Genetics, University Medical Center Utrecht, The Netherlands
    Traffic 3:321-30. 2002
    ..Exosomes may have evolved early in the evolution of multicellular organisms and also seem to be important for tissue developmental processes...
  13. ncbi Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics
    Erica L Dahl
    Department of Medicine, Division of Infectious Disease, Box 0811, University of California, San Francisco, San Francisco, CA 94143, USA
    Trends Parasitol 24:279-84. 2008
    ..Interestingly, the antibiotics thiostrepton and rifampin are fast acting and might target additional processes outside the apicoplast...
  14. ncbi Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?
    Corinne Mercier
    Institut Jean Roget, Universite Joseph Fourier, CNRS UMR 5163, Place du Commandant Nal, 38700 La Tronche, France
    Int J Parasitol 35:829-49. 2005
    Together with micronemes and rhoptries, dense granules are specialised secretory organelles of Apicomplexa parasites...
  15. ncbi Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
    B Trinczek
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, D 22607 Hamburg, Germany
    J Cell Sci 112:2355-67. 1999
    ....
  16. ncbi Peroxisomes as dynamic organelles: autophagic degradation
    Masahide Oku
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    FEBS J 277:3289-94. 2010
    ..Physiological functions of this process (especially cellular remodeling) in mammalian cells and in a phytopathogenic fungus are also introduced...
  17. ncbi Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    Katherine A Mattos
    Laboratórios de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    J Leukoc Biol 87:371-84. 2010
    ....
  18. ncbi Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles
    Magdalena Lebiedzinska
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw, Poland
    Int J Biochem Cell Biol 41:1805-16. 2009
    ..dynamic contacts between mitochondria, the plasma membrane, the endoplasmic reticulum, and other subcellular organelles. Many cellular processes require proper cooperation between the plasma membrane, the nucleus and subcellular ..
  19. ncbi CK1 activates minus-end-directed transport of membrane organelles along microtubules
    Kazuho Ikeda
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Biol Cell 22:1321-9. 2011
    ....
  20. ncbi Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  21. ncbi The lipid droplet is an important organelle for hepatitis C virus production
    Yusuke Miyanari
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Nat Cell Biol 9:1089-97. 2007
    ..It dynamically moves through the cytoplasm, interacting with other organelles, including the endoplasmic reticulum (ER)...
  22. ncbi Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole
    S Hakansson
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 S Euclid Avenue, St Louis, MO 63110, USA
    EMBO J 20:3132-44. 2001
    Rapid discharge of secretory organelles called rhoptries is tightly coupled with host cell entry by the protozoan parasite Toxoplasma gondii...
  23. ncbi Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles
    E Delannoy
    ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, WA, Australia
    Biochem Soc Trans 35:1643-7. 2007
    PPR (pentatricopeptide repeat) genes form a large family particularly prevalent in higher plants and targeted to organelles. They are involved in many post-transcriptional processes such as splicing, editing, processing and translation...
  24. ncbi Mechanisms shaping the membranes of cellular organelles
    Yoko Shibata
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 25:329-54. 2009
    Cellular organelles have characteristic morphologies that arise as a result of different local membrane curvatures...
  25. ncbi Gene transfer from organelles to the nucleus: frequent and in big chunks
    William Martin
    Institute of Botany III, , , , Germany
    Proc Natl Acad Sci U S A 100:8612-4. 2003
  26. ncbi Lipid droplets as dynamic organelles connecting storage and efflux of lipids
    Sven Olof Olofsson
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Biochim Biophys Acta 1791:448-58. 2009
    Neutral lipids are stored in the cytosol in so-called lipid droplets. These are dynamic organelles with neutral lipids as the core surrounded by a monolayer of amphipathic lipids (phospholipids and cholesterol) and specific proteins (PAT ..
  27. ncbi Global analysis of protein localization in budding yeast
    Won-Ki Huh
    Howard Hughes Medical Institute, University of California-San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143-2240, USA
    Nature 425:686-91. 2003
    ..in the context of transcriptional, genetic, and protein-protein interaction data helps reveal the logic of transcriptional co-regulation, and provides a comprehensive view of interactions within and between organelles in eukaryotic cells.
  28. ncbi Death receptor ligation triggers membrane scrambling between Golgi and mitochondria
    S Ouasti
    Faculty of Life Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester, UK
    Cell Death Differ 14:453-61. 2007
    Subcellular organelles such as mitochondria, endoplasmic reticulum (ER) and the Golgi complex are involved in the progression of the cell death programme...
  29. ncbi Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes
    Roberto Docampo
    Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, GA 30602, USA
    Philos Trans R Soc Lond B Biol Sci 365:775-84. 2010
    Acidocalcisomes are acidic electron-dense organelles, rich in polyphosphate (poly P) complexed with calcium and other cations...
  30. ncbi Rosella: a fluorescent pH-biosensor for reporting vacuolar turnover of cytosol and organelles in yeast
    Carlos J Rosado
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, Australia
    Autophagy 4:205-13. 2008
    ..We further demonstrated the value of the biosensor as a reporter of autophagy by employing fluorescence-activated cell sorting of discrete populations of cells undergoing autophagy...
  31. ncbi TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP
    Michael X Zhu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH, USA
    FEBS Lett 584:1966-74. 2010
    ..With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled...
  32. ncbi Lipoxygenase-dependent degradation of storage lipids
    I Feussner
    Dept Molecular Cell Biology, Institute of Plant Genetics and Crop Plant Research, D 06466, Corrensstr 3, Gatersleben, Germany
    Trends Plant Sci 6:268-73. 2001
    ..The free hydroperoxy fatty acids are subsequently reduced to their hydroxy derivatives, which might in turn undergo beta-oxidation...
  33. ncbi Acidocalcisomes - conserved from bacteria to man
    Roberto Docampo
    Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, Georgia 30602, USA
    Nat Rev Microbiol 3:251-61. 2005
    Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles rich in calcium and polyphosphate, are the only organelles that have been conserved during evolution from prokaryotes to eukaryotes...
  34. ncbi In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii
    Zhongqiang Chen
    Department of Biology, Penn Genomic Frontiers Institute, and the Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e3611. 2008
    ..including the human pathogens Toxoplasma gondii and Plasmodium falciparum, employ specialized secretory organelles (micronemes, rhoptries, dense granules) to invade and survive within host cells...
  35. ncbi The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation
    H Lin
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 120:947-56. 1994
    ..Our results imply that Drosophila fusomes are required for ovarian cyst formation and suggest that membrane skeletal proteins regulate cystocyte divisions...
  36. ncbi Bacterial microcompartment organelles: protein shell structure and evolution
    Todd O Yeates
    Department of Chemistry and Biochemistry, Institute of Genomics and Proteomics, University of California, Los Angeles, California 90095, USA
    Annu Rev Biophys 39:185-205. 2010
    Some bacteria contain organelles or microcompartments consisting of a large virion-like protein shell encapsulating sequentially acting enzymes...
  37. ncbi Fungal evo-devo: organelles and multicellular complexity
    Gregory Jedd
    Temasek Life Sciences Laboratory and Department of Biological Sciences, The National University of Singapore, Singapore 117604
    Trends Cell Biol 21:12-9. 2011
    ..phyla, and the endoplasmic reticulum (ER)-derived septal pore cap (SPC) of the Basidiomycota, are both fungal organelles that prevent cytoplasmic bleeding when multicellular hyphal filaments are wounded...
  38. ncbi Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae
    Kasinath Kuravi
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    J Cell Sci 119:3994-4001. 2006
    ..This organelle divided at a very late stage of the budding process, possibly during cytokinesis...
  39. ncbi Conserving a volatile metabolite: a role for carboxysome-like organelles in Salmonella enterica
    Joseph T Penrod
    Microbiology Section, Division of Biological Sciences, University of California Davis, Davis, CA, USA
    J Bacteriol 188:2865-74. 2006
    ..We propose that carboxysome-like organelles help bacteria conserve certain volatile metabolites-CO(2) or acetaldehyde-perhaps by providing a low-pH ..
  40. ncbi Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis
    John J Lemasters
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 27599 7090, USA
    Gastroenterology 129:351-60. 2005
    ..on cell death has grown enormously in size and complexity, a pattern has emerged that each of several distinct organelles (plasma membrane, mitochondrion, nucleus, endoplasmic reticulum, lysosome) gives rise to signals that induce ..
  41. ncbi RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function
    F Schmitz
    Howard Hughes Medical Institute, Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 28:857-72. 2000
    ..Our results define a unique component of synaptic ribbons and suggest that RIBEYE evolved in vertebrates under utilization of a preexisting protein to build a unique scaffold for a specialized synapse...
  42. ncbi A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
    H Lin
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 124:2463-76. 1997
    ..We have also identified a second and novel gene, piwi, whose mutations abolish germline stem cell division...
  43. ncbi Autophagy and vacuole homeostasis: a case for self-degradation?
    Dalibor Mijaljica
    Department of Biochemistry and Molecular Biology, and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton Campus, Victoria, Australia
    Autophagy 3:417-21. 2007
    ..of the vacuole, especially during nutrient deprivation, is the degradation of proteins, other macromolecules and organelles. To deliver these components into the vacuolar lumen, specific and sophisticated transport pathways such as ..
  44. ncbi Characterization of isolated acidocalcisomes of Trypanosoma cruzi
    D A Scott
    Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 275:24215-21. 2000
    ..Assays for other organelles generally indicated no enrichment in the acidocalcisome fraction; glycosomes were concentrated 5-fold...
  45. ncbi Complementation of a Toxoplasma gondii ROP1 knock-out mutant using phleomycin selection
    D Soldati
    Department of Microbiology and Immonology, Stanford University School of Medicine, CA 94305 5402, USA
    Mol Biochem Parasitol 74:87-97. 1995
    ..These results demonstrate the utility of the reverse genetic approach in the study of Toxoplasma gene function and provide a further selectable marker for such manipulations...
  46. ncbi Fat on the move: intracellular motion of lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Biochem Soc Trans 37:991-6. 2009
    Lipid droplets are intracellular organelles that play central roles in lipid metabolism. In many cells, lipid droplets undergo active motion, typically along microtubules...
  47. ncbi Hydrogenosomes, mitochondria and early eukaryotic evolution
    T Martin Embley
    Department of Zoology, The Natural History Museum, London, SW7 5BD, UK
    IUBMB Life 55:387-95. 2003
    Available data suggest that unusual organelles called hydrogenosomes, that make ATP and hydrogen, and which are found in diverse anaerobic eukaryotes, were once mitochondria...
  48. ncbi Systematic analysis of Arabidopsis organelles and a protein localization database for facilitating fluorescent tagging of full-length Arabidopsis proteins
    Shijun Li
    Department of Plant Biology, Carnegie Institution, Stanford, California 94305, USA
    Plant Physiol 141:527-39. 2006
    ..The database can be searched, browsed, and downloaded using a Web browser at http://aztec.stanford.edu/gfp/. The software can also be downloaded from the same Web site for local installation...
  49. ncbi Mitosomes in Entamoeba histolytica contain a sulfate activation pathway
    Fumika Mi-ichi
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Proc Natl Acad Sci U S A 106:21731-6. 2009
    Hydrogenosomes and mitosomes are mitochondrion-related organelles in anaerobic/microaerophilic eukaryotes with highly reduced and divergent functions...
  50. ncbi CdTe nanoparticles display tropism to core histones and histone-rich cell organelles
    Jennifer Conroy
    Department of Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland
    Small 4:2006-15. 2008
    ..These findings strongly suggest that charge-mediated QD/histone interactions could provide the basis for QD nuclear localization downstream of intracellular transport mechanisms...
  51. ncbi Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics
    Marjan Huizing
    Cell Biology of Metabolic Disorders Unit, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Genomics Hum Genet 9:359-86. 2008
    Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share various features with lysosomes, but are distinct in function, morphology, and composition...
  52. ncbi Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
    Nadia F Lamour
    Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Lipid Res 48:1293-304. 2007
    ..In conclusion, these results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT...
  53. ncbi Proteomics in Trypanosoma cruzi--localization of novel proteins to various organelles
    Marcela Ferella
    Department of Cell and Molecular Biology CMB, Karolinska Institutet, Stockholm, Sweden
    Proteomics 8:2735-49. 2008
    ..The results demonstrate that the use of enriched subcellular fractions allows the detection of T. cruzi proteins that are undetected by whole cell proteomic methods...
  54. ncbi Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
    Weihua Fei
    Department of Biochemistry, National University of Singapore, Singapore 117597, Republic of Singapore
    J Cell Biol 180:473-82. 2008
    Lipid droplets (LDs) are emerging cellular organelles that are of crucial importance in cell biology and human diseases...
  55. ncbi Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts
    Chris Carrie
    Australian Research Council Centre of Excellence in Plant Energy Biology, M316, University of Western Australia, Crawley, Australia
    FEBS J 276:1187-95. 2009
    ..This minireview summarizes dual targeting in terms of signals, passenger proteins, receptors, regulation, why proteins may need to be dual targeted and the future challenges that remain in this area...
  56. ncbi Reductive evolution of the mitochondrial processing peptidases of the unicellular parasites trichomonas vaginalis and giardia intestinalis
    Ondrej Smid
    Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    PLoS Pathog 4:e1000243. 2008
    ..The unique monomeric structure of the Giardia enzyme, and the co-evolving properties of the Giardia enzyme and substrate, provide a compelling example of the power of reductive evolution to shape parasite biology...
  57. ncbi The plastid-like organelle of apicomplexan parasites as drug target
    J Wiesner
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, Giessen, Germany
    Curr Pharm Des 14:855-71. 2008
    ..In vitro antimalarial activity was shown for inhibitors of peptide deformylase and the import of apicoplast-targeted proteins. Work on various other inhibitors of apicoplast-located biochemical processes is ongoing...
  58. ncbi Hyphal growth: a tale of motors, lipids, and the Spitzenkörper
    Gero Steinberg
    , Karl-von-Frisch-Strasse, D-35043 Marburg, Germany
    Eukaryot Cell 6:351-60. 2007
  59. ncbi Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I
    Ivan Hrdy
    Department of Parasitology, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
    Nature 432:618-22. 2004
    Hydrogenosomes are double-membraned ATP-producing and hydrogen-producing organelles of diverse anaerobic eukaryotes...
  60. ncbi Proteins under new management: lipid droplets deliver
    Michael A Welte
    Rosenstiel Biomedical Research Center and Department of Biology, 415 South Street, Waltham, MA 02454, USA
    Trends Cell Biol 17:363-9. 2007
    Lipid droplets are ubiquitous organelles that store neutral lipids and have crucial roles in lipid metabolism...
  61. ncbi Why have organelles retained genomes?
    H L Race
    Botanisches Institut der Ludwig Maximilians Universität, Munchen, Germany
    Trends Genet 15:364-70. 1999
    ..If most genes have been transferred from organelles to the nucleus during evolution, why not all? What selective pressure maintains genomes in organelles? Electron ..
  62. ncbi Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum
    Bernardo J Foth
    Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Parkville, VIC 3010, Australia
    Science 299:705-8. 2003
    ..Similarly, putative Hsp70 (DnaK) binding sites present in the transit peptide proved to be important for correct targeting...
  63. ncbi Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
    Ashley M Vaughan
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Cell Microbiol 11:506-20. 2009
    ..Malaria parasites therefore depend on the intrinsic FAS II pathway only at one specific life cycle transition point, from liver to blood...
  64. ncbi Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants
    Elke Vermassen
    Laboratorium voor Fysiologie, K.U.Leuven, Campus Gasthuisberg O/N, B-3000 Leuven, Belgium
    Biol Cell 96:3-17. 2004
    ..This indicates that the cell must be able to regulate not only IP3R expression but also its distribution. The various proteins potentially determining IP3R localization and redistribution will therefore be discussed...
  65. ncbi Tunneling nanotube (TNT)-like structures facilitate a constitutive, actomyosin-dependent exchange of endocytic organelles between normal rat kidney cells
    Steffen Gurke
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Exp Cell Res 314:3669-83. 2008
    ..intercellular membranous bridges that mediate the transfer of various cellular components including endocytic organelles. To gain further insight into the magnitude and mechanism of organelle transfer, we performed quantitative ..
  66. ncbi Eukaryotic protein production in designed storage organelles
    Margarita Torrent
    Departament de Genetica Molecular, Consorci CSIC IRTA, Jordi Girona, Barcelona, Spain
    BMC Biol 7:5. 2009
    Protein bodies (PBs) are natural endoplasmic reticulum (ER) or vacuole plant-derived organelles that stably accumulate large amounts of storage proteins in seeds...
  67. ncbi Motile sperm organelle morphology examination is stricter than Tygerberg criteria
    J B A Oliveira
    Centre for Human Reproduction Professor Franco Jr, Ribeirao Preto, Sao Paulo, Brazil
    Reprod Biomed Online 18:320-6. 2009
    ..In addition, MSOME should be used for selection of spermatozoa for intracytoplasmic sperm injection based on the already published literature, as this is a good selection tool...
  68. ncbi Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum
    Norma Marchesini
    Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 277:8146-53. 2002
    ..Both organelles also possessed a vacuolar H(+)-ATPase, an H(+)-pyrophosphatase, and a Ca(2+)-ATPase, as determined by ..
  69. ncbi The pentameric vertex proteins are necessary for the icosahedral carboxysome shell to function as a CO2 leakage barrier
    Fei Cai
    Department of Chemistry and Biochemistry, The University of Southern Mississippi, Hattiesburg, Mississippi, United States of America
    PLoS ONE 4:e7521. 2009
    ..Two types of shell protein constituents are common to carboxysomes and related microcompartments of heterotrophic bacteria, and the genes for these proteins are found in a large variety of bacteria...
  70. ncbi Structural basis of enzyme encapsulation into a bacterial nanocompartment
    Markus Sutter
    ETH Zurich, Institute of Molecular Biology and Biophysics, Schafmattstrasse 20, 8093 Zurich, Switzerland
    Nat Struct Mol Biol 15:939-47. 2008
    ..It occurs at varying levels of complexity ranging from eukaryotic organelles and the bacterial microcompartments, to the molecular reaction chambers formed by enzyme assemblies...
  71. ncbi A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii
    Giel G van Dooren
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, 30602, USA
    Curr Biol 19:267-76. 2009
    ..Apicoplasts lack the conserved machinery that divides chloroplasts in plants and red algae, suggesting that these mechanisms are unique...
  72. ncbi Genome-wide analysis of signaling networks regulating fatty acid-induced gene expression and organelle biogenesis
    Ramsey A Saleem
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Cell Biol 181:281-92. 2008
    ..Our study represents the first global study of signaling networks regulating the biogenesis of an organelle...
  73. ncbi Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion
    Anne Aurélie Raymond
    UMR5165 CNRS University of Toulouse III, Institut Fédératif de Recherche Claude de Préval INSERM CNRS Université Paul Sabatier Centre Hospitalier Universitaire de Toulouse 31059 Toulouse, France
    Mol Cell Proteomics 7:2151-75. 2008
    Lamellar bodies (LBs) are tubulovesicular secretory organelles of epithelial cells related to lysosomes...
  74. ncbi Acidic compartments and rhoptry formation in Toxoplasma gondii
    M K Shaw
    Department of Biology, University of Pennsylvania, Philadelphia 19104 6018, USA
    Parasitology 117:435-43. 1998
    ..No labelling of other secretory organelles (micronemes and dense granules), the ER, Golgi or any other membrane-bounded organelles or anything resembling a ..
  75. ncbi Compositional properties of green-plant plastid genomes
    Junko Kusumi
    Department of Biology, Graduate School of Sciences, Kyushu University, Ropponmatsu, Fukuoka, 810 8560, Japan
    J Mol Evol 60:417-25. 2005
    ..We found an increase in eqGC(3) after the divergence of liverworts. These results suggest that genome-wide factors such as GC mutational bias are important for the biased base composition in the Pt genomes...
  76. ncbi Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency
    Verónica T Cheli
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:861-78. 2010
    Biogenesis of lysosome-related organelles complex 1 (BLOC-1) is a protein complex formed by the products of eight distinct genes...
  77. ncbi A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii
    Amy E Derocher
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109, USA
    Eukaryot Cell 7:1518-29. 2008
    ..This protein reveals a population of vesicles, hitherto unrecognized as being highly abundant in the cell, which may serve to transport proteins to the apicoplast...
  78. ncbi Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries: further insights into the role of cholesterol
    Sebastien Besteiro
    Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques DIMNP, Universités de Montpellier II et I, Centre National de la Recherche Scientifique CNRS, UMR 5235, Montpellier, F 34095, France
    Biochem J 415:87-96. 2008
    Rhoptries are secretory organelles involved in the virulence of the human pathogen Toxoplasma gondii...
  79. ncbi Powering membrane traffic in endocytosis and recycling
    Thierry Soldati
    Department de Biochimie, Faculte des Sciences, Universite de Geneve, 30 Quai Ernest Ansermet, Sciences II, CH 1211 Geneve 4, Switzerland
    Nat Rev Mol Cell Biol 7:897-908. 2006
    ..Molecular motors that move on tracks of actin filaments or microtubules mediate the movement of organelles and transport between compartments...
  80. ncbi Organellar dynamics during the cell cycle of Toxoplasma gondii
    Manami Nishi
    Departments of Biology, and Cell and Developmental Biology, University of Pennsylvania, Philadelphia PA 19104, USA
    J Cell Sci 121:1559-68. 2008
    ..gondii tachyzoites to determine how these unicellular eukaryotes efficiently package a complete set of organelles, maintaining the highly polarized organization necessary for host cell invasion and pathogenesis...
  81. ncbi Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography
    Ohad Medalia
    Max Planck Institute for Biochemistry, D-82152 Martinsried, Germany
    Science 298:1209-13. 2002
    ..At a resolution of 5 to 6 nanometers, single macromolecules with distinct shapes, such as the 26S proteasome, can be identified in an unperturbed cellular environment...
  82. ncbi Fluorescent protein tagging in Toxoplasma gondii: identification of a novel inner membrane complex component conserved among Apicomplexa
    Marc-Jan Gubbels
    Center for Tropical and Emerging Global Diseases, University of Georgia, 724 Biological Sciences Building, Athens 30602, USA
    Mol Biochem Parasitol 137:99-110. 2004
    ..In addition to organelles shared among all eukaryotes, the organism possesses a number of specialized compartments with important roles in ..
  83. ncbi The apical organelles of malaria merozoites: host cell selection, invasion, host immunity and immune evasion
    P Preiser
    Division of Parasitology, The National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK
    Microbes Infect 2:1461-77. 2000
    ..This article is a broad overview of the molecular strategies employed by the merozoite, an invasive form of the malaria parasite, to successfully invade a suitable red blood cell...
  84. ncbi Organelle degradation during the lens and erythroid differentiation is independent of autophagy
    Makoto Matsui
    Department of Bioregulation and Metabolism, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    Biochem Biophys Res Commun 339:485-9. 2006
    ..In contrast to the ubiquitin-proteasome system, autophagy can also degrade organelles. Here we examined a possible role of autophagy in organelle degradation during lens and erythroid ..
  85. ncbi The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
    Yoshiharu Kawaguchi
    Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA
    Cell 115:727-38. 2003
    ..These findings identify HDAC6 as a crucial player in the cellular management of misfolded protein-induced stress...
  86. ncbi Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes
    Amanda M Mathis
    Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, Chapel 27599, USA
    Antimicrob Agents Chemother 50:2185-91. 2006
    ..nucleus and kinetoplast, but at later time points, they concentrate in non-DNA-containing cytoplasmic organelles. Analyses of the kinetics of uptake and intracellular distribution are necessary to begin to define ..
  87. ncbi Vesicle-associated brain myosin-V can be activated to catalyze actin-based transport
    L L Evans
    Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63110, USA
    J Cell Sci 111:2055-66. 1998
    ..These studies provide direct evidence that vesicle-associated myosin-V is capable of actin transport, and suggest that the activity of myosin-V may be regulated by proteins or lipids on the vesicle surface...
  88. ncbi Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
    M Tsukada
    Department of Biology, College of Arts and Sciences, University of Tokyo, Japan
    FEBS Lett 333:169-74. 1993
    ..These results on the apg mutants suggest that autophagy via autophagic bodies is indispensable for protein degradation in the vacuoles under starvation conditions, and that at least 15 APG genes are involved in autophagy in yeast...
  89. ncbi Entamoeba histolytica mitosomes: organelles in search of a function
    Penelope Aguilera
    School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, United Kingdom
    Exp Parasitol 118:10-6. 2008
    It has been more than eight years since the discovery of mitosomes (mitochondrial remnant organelles) in the intestinal human pathogen Entamoeba histolytica...
  90. ncbi Cell cycle-regulated vesicular trafficking of Toxoplasma APT1, a protein localized to multiple apicoplast membranes
    Anuradha Karnataki
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109, USA
    Mol Microbiol 63:1653-68. 2007
    ..After plastid division, the protein resumes a circumplastid colocalization. These studies demonstrate for the first time that vesicular trafficking likely plays a role in the apicoplast biogenesis...
  91. ncbi Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions
    Tim Levine
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Trends Cell Biol 14:483-90. 2004
    ..This transport occurs at narrow cytoplasmic gaps called membrane contact sites (MCSs), at which two organelles come into close apposition...
  92. ncbi Micellar nanocontainers distribute to defined cytoplasmic organelles
    Radoslav Savic
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    Science 300:615-8. 2003
    ..Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus...
  93. ncbi [Electron microscopy and ultracytochemistry of blood lymphocytes containing Gall bodies in healthy individuals]
    K P Zak
    Tsitol Genet 37:56-60. 2003
    ..GB show a high activity of acid phosphatase and positive reaction to glycogen. The data obtained suggest the leading role of GB in the production of cytokins and other biologically active substances...
  94. ncbi Localization of ISG15 and conjugated proteins in bovine endometrium using immunohistochemistry and electron microscopy
    Kathy J Austin
    Reproductive Biology Program, Department of Animal Science, University of Wyoming, Laramie, WY 82071 3684, USA
    Endocrinology 145:967-75. 2004
    ..Using transmission electron microscopy and immunogold labeling, ISG15 was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells: nucleus, perinuclear space, cytosol, ..
  95. ncbi Microtubule/organelle motility assays
    C M Waterman-Storer
    University of North Carolina, Chapel Hill, North Carolina, USA
    Curr Protoc Cell Biol . 2001
    ..Various combinations of isolated endoplasmic reticulum (ER) and Golgi apparatus organelles, cytosol containing motor proteins and other soluble factors, nucleotides, and specific pharmacological reagents ..
  96. ncbi A fission yeast kinesin affects Golgi membrane recycling
    S C Brazer
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Yeast 16:149-66. 2000
    ..We conclude that Klp3 plays a role in BFA-induced membrane transport. The nucleotide sequence of S. pombe klp3(+) was submitted to GenBank under Accession No. AF154055...
  97. ncbi A transient forward-targeting element for microneme-regulated secretion in Toxoplasma gondii
    Susannah D Brydges
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biol Cell 100:253-64. 2008
    ..feature of proteins destined for regulated secretion, which for Toxoplasma occurs through two distinct invasion organelles, rhoptries and micronemes...
  98. ncbi AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis
    Uwe Schumann
    Lehrstuhl fur Botanik, Technische Universitat Munchen, Am Hochanger 4, D 85350 Freising, Germany
    Proc Natl Acad Sci U S A 100:9626-31. 2003
    ..The ultrastructural knockout phenotype of AthPEX10p suggests that this protein in Arabidopsis is essential for peroxisome, oleosome, and protein transport vesicle formation...
  99. ncbi The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation
    Richard S Saliba
    Division of Pathology, Institute of Ophthalmology, University College London, UK
    J Cell Sci 115:2907-18. 2002
    ....
  100. ncbi Ultrastructural changes in goat interspecies and intraspecies reconstructed early embryos
    Yong Tao
    Faculty of Animal Genetics, Breeding and Reproduction, Department of Animal Sciences, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
    Zygote 16:93-110. 2008
    ..In particular, the interspecies cloned embryos showed more severe destruction. These ultrastructural deviations might contribute to the compromised developmental potential of reconstructed embryos...
  101. ncbi A unique mechanism of nuclear division in Giardia lamblia involves components of the ventral disk and the nuclear envelope
    Alberto J Solari
    Centro de Investigaciones en Reproduccion, Facultad de Medicina, UBA, Buenos Aires, Argentina
    Biocell 27:329-46. 2003
    ..The dividing Giardia lacks a typical, microtubular spindle either inside or outside the nuclei. The nuclear envelope seems to be the only structure involved in the final division of the parent-daughter nuclei...

Research Grants91

  1. Oocyte polarity and mRNA localization in Zebrafish
    FLORENCE LOUISE MARLOW; Fiscal Year: 2010
    ..the earliest indicator of cell polarity is an asymmetric aggregate, known as the Balbiani body, that includes organelles, proteins, and, in some animals, mRNAs encoding germline determinants...
  2. REGULATION OF GLYCOSOMAL BIOGENESIS IN T. BRUCEI
    C Wang; Fiscal Year: 1993
    Glycosomes, the membrane-bound microbody organelles in the bloodstream form of Trypanosoma brucei, contain seven glycolytic enzymes and two glycerol metabolizing enzymes...
  3. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007
    ..Motile forms of these organelles are capable of propelling some cells like sperm and protozoa through a liquid environment while other cells like ..
  4. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..Motile forms of these organelles are capable of propelling some cells like sperm and protozoa through a liquid environment while other cells like ..
  5. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
    ..cell and molecular biology of cilia and flagella have led to an increase in not only basic research on these organelles, but clinical research related to the role of cilia and flagella in certain diseases...
  6. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2010
    ..Recent studies indicate that NAADP mobilizes Ca2+ from lysosome-related acidic organelles;however, the molecular identity of the Ca2+ release channels and the specific internal stores involved in NAADP-..
  7. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok Saluja; Fiscal Year: 2009
    ..digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen...
  8. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2010
    ..digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen...
  9. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2010
    ..digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen...
  10. Hermansky Pudlak Syndrome & melanosome formation
    GRACA GRACA RAPOSO; Fiscal Year: 2010
    Melanosomes are tissue-specific intracellular organelles that function in the biosynthesis, storage, and transport of melanins in pigment cells of the eye and skin melanocytes...
  11. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
    ..need to be delivered intracellularly to exert their therapeutic action within the cytoplasm or specific organelles, such as nuclei, lysosomes, or mitochondria...
  12. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir P Torchilin; Fiscal Year: 2010
    ..need to be delivered intracellularly to exert their therapeutic action within the cytoplasm or specific organelles, such as nuclei, lysosomes, or mitochondria...
  13. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
    ..need to be delivered intracellularly to exert their therapeutic action within the cytoplasm or specific organelles, such as nuclei, lysosomes, or mitochondria...
  14. Autophagy in Antiviral Immunity
    Akiko Iwasaki; Fiscal Year: 2010
    ..evolutionarily conserved pathway designed to maintain cellular homeostasis by degrading long-lived proteins and organelles in the cytosol. It is also used as a survival mechanism under starvation conditions...
  15. Role of BLOC-3 in Lysosome and Melanosome Biogenesis
    ESTEBAN DELL ANGELICA; Fiscal Year: 2007
    Melanosomes are cell-type-specific, membrane-bounded organelles in which melanin pigments are synthesized and stored...
  16. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2010
    ..We hypothesize that mitochondria function as hypoxia sensors in the cell. These organelles appear to trigger adaptive responses by initiating a signaling cascade involving an increased release of ..
  17. ON THE ROLE OF THE HPS GENE PRODUCT IN MELANOCYTES
    Raymond Boissy; Fiscal Year: 2002
    ..These characteristics result from aberrations in a specific group of cellular organelles, (i.e...
  18. MITOCHONDRIAL DYNAMICS--MORPHOLOGY/DIVISION/SEGREGATION
    Robert Jensen; Fiscal Year: 1999
    Mitochondria are dynamic organelles found in virtually all eukaryotic cells and show striking variations in their location, number and structure in different cell types...
  19. Hermansky Pudlak Syndrome & melanosome formation
    Michael Marks; Fiscal Year: 2007
    ..Syndrome (HPS) is a heritable multisystem disorder in which tissue-specific, lysosome-related subcellular organelles in certain cell types are improperly formed...
  20. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 1993
    ..and storage in the brain, relatively little is known about the molecular composition of the key synaptic organelles involved in transmission or about the mechanisms by which the functions of these organelles are regulated...
  21. GLOBAL CONTROL OF DIFFERENTIATION IN CAULOBACTER
    YVES BRUN; Fiscal Year: 2009
    ..The localization of proteins and organelles at the cell poles is an important component of bacterial interaction with the environment; many pathogenic ..
  22. GLOBAL CONTROL OF DIFFERENTIATION IN CAULOBACTER
    Yves V Brun; Fiscal Year: 2010
    ..The localization of proteins and organelles at the cell poles is an important component of bacterial interaction with the environment;many pathogenic ..
  23. Apoptosis and Necrosis in Pancreatitis
    Anna Gukovskaya; Fiscal Year: 2009
    ..Autophagy is an important adaptive process through which the cell degrades unneeded or defective cytoplasmic organelles. Organelles to be degraded are sequestered within double-membrane vacuoles called autophagosomes, which then ..
  24. Apoptosis and Necrosis in Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2010
    ..Autophagy is an important adaptive process through which the cell degrades unneeded or defective cytoplasmic organelles. Organelles to be degraded are sequestered within double-membrane vacuoles called autophagosomes, which then ..
  25. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2006
    Cilia and flagella are eukaryotic organelles essential for both motility and sensory transduction in animals, animals and protozoa...
  26. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN PFISTER; Fiscal Year: 2009
    ..Cytoplasmic dynein is the motor for microtubule-based fast transport of various membranous organelles, including mitochondria, endosomes, and viruses in the retrograde direction from the axon terminus to the cell ..
  27. GENETICS OF CAENORHABDITIS ELEGANS SPERM MORPHOGENESIS
    STEVEN L HERNAULT; Fiscal Year: 2003
    When cells divide, organelles and macromolecules can be partitioned unequally between daughters...
  28. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN PFISTER; Fiscal Year: 2009
    ..Cytoplasmic dynein is the motor for microtubule-based fast transport of various membranous organelles, including mitochondria, endosomes, and viruses in the retrograde direction from the axon terminus to the cell ..
  29. Regulation of motility and organelle assembly at the Pseudomonas aeruginosa pole
    Barbara I Kazmierczak; Fiscal Year: 2010
    ..Two polar surface organelles of P...