organelles

Summary

Summary: Specific particles of membrane-bound organized living substances present in eukaryotic cells, such as the MITOCHONDRIA; the GOLGI APPARATUS; ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.

Top Publications

  1. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
  2. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
  3. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
  4. ncbi Lipid droplets: a unified view of a dynamic organelle
    Sally Martin
    Institute for Molecular Bioscience, and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia
    Nat Rev Mol Cell Biol 7:373-8. 2006
  5. pmc Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
    Sooyeon Lee
    Department of Neuroscience Physiology, New York University Langone Medical Center, New York, New York 10016, USA
    J Neurosci 31:7817-30. 2011
  6. pmc Photoacoustic tomography: in vivo imaging from organelles to organs
    Lihong V Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Science 335:1458-62. 2012
  7. pmc NAADP mobilizes calcium from acidic organelles through two-pore channels
    Peter J Calcraft
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
    Nature 459:596-600. 2009
  8. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
  9. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
  10. ncbi Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Christopher J Tonkin
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Biochem Parasitol 137:13-21. 2004

Research Grants

Detail Information

Publications332 found, 100 shown here

  1. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
    ..in the context of transcriptional, genetic, and protein-protein interaction data helps reveal the logic of transcriptional co-regulation, and provides a comprehensive view of interactions within and between organelles in eukaryotic cells.
  2. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
    ..Thus, XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells...
  3. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
    Long underappreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting biology...
  4. ncbi Lipid droplets: a unified view of a dynamic organelle
    Sally Martin
    Institute for Molecular Bioscience, and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia
    Nat Rev Mol Cell Biol 7:373-8. 2006
    ..seem to be able to generate lipid droplets, their biogenesis, regulatory mechanisms and interactions with other organelles remain largely elusive...
  5. pmc Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
    Sooyeon Lee
    Department of Neuroscience Physiology, New York University Langone Medical Center, New York, New York 10016, USA
    J Neurosci 31:7817-30. 2011
    ..Mitochondria and other organelles lacking cathepsins moved normally under these conditions, indicating that the general functioning of the axonal ..
  6. pmc Photoacoustic tomography: in vivo imaging from organelles to organs
    Lihong V Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Science 335:1458-62. 2012
    ..tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs...
  7. pmc NAADP mobilizes calcium from acidic organelles through two-pore channels
    Peter J Calcraft
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
    Nature 459:596-600. 2009
    ..Thus, TPCs form NAADP receptors that release Ca(2+) from acidic organelles, which can trigger further Ca(2+) signals via sarcoplasmic/endoplasmic reticulum...
  8. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    ..Parasite proteins that bind erythrocyte receptors during invasion are localized in apical organelles called micronemes and rhoptries...
  9. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  10. ncbi Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Christopher J Tonkin
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Biochem Parasitol 137:13-21. 2004
    The apicoplast and mitochondrion of the malaria parasite Plasmodium falciparum are important intracellular organelles and targets of several anti-malarial drugs...
  11. pmc Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles
    David L Alexander
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Pathog 1:e17. 2005
    ..this process, apical membrane antigen 1 (AMA1) is released onto the parasite surface from specialized secretory organelles called micronemes. The T...
  12. doi Mechanisms shaping the membranes of cellular organelles
    Yoko Shibata
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 25:329-54. 2009
    Cellular organelles have characteristic morphologies that arise as a result of different local membrane curvatures...
  13. pmc Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    K Stamer
    Max Planck Unit for Structural Molecular Biology, 22607 Hamburg, Germany
    J Cell Biol 156:1051-63. 2002
    We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells...
  14. pmc Lipid bodies in inflammatory cells: structure, function, and current imaging techniques
    Rossana C N Melo
    Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora UFJF, Juiz de Fora, MG, Brazil
    J Histochem Cytochem 59:540-56. 2011
    Lipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as functionally active organelles linked to diverse biological functions and human diseases...
  15. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  16. ncbi Kiss and spit: the dual roles of Toxoplasma rhoptries
    John C Boothroyd
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nat Rev Microbiol 6:79-88. 2008
    ..Upon entry, this Apicomplexan parasite co-opts host functions for its own purposes. An unusual set of apical organelles, named rhoptries, contain some of the machinery that is used by T...
  17. ncbi Proteomics of organelles and large cellular structures
    John R Yates
    Department of Cell Biology, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 6:702-14. 2005
    The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures...
  18. doi Lipid droplets as dynamic organelles connecting storage and efflux of lipids
    Sven Olof Olofsson
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Biochim Biophys Acta 1791:448-58. 2009
    Neutral lipids are stored in the cytosol in so-called lipid droplets. These are dynamic organelles with neutral lipids as the core surrounded by a monolayer of amphipathic lipids (phospholipids and cholesterol) and specific proteins (PAT ..
  19. doi Metabolic pathways in the apicoplast of apicomplexa
    Frank Seeber
    Robert Koch Institut, Berlin, Germany
    Int Rev Cell Mol Biol 281:161-228. 2010
    ..Finally, we highlight some aspects that emerged from recent publications and were not discussed previously with regard to Apicomplexa...
  20. doi Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles
    Magdalena Lebiedzinska
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw, Poland
    Int J Biochem Cell Biol 41:1805-16. 2009
    ..dynamic contacts between mitochondria, the plasma membrane, the endoplasmic reticulum, and other subcellular organelles. Many cellular processes require proper cooperation between the plasma membrane, the nucleus and subcellular ..
  21. doi Peroxisomes as dynamic organelles: autophagic degradation
    Masahide Oku
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    FEBS J 277:3289-94. 2010
    ..Physiological functions of this process (especially cellular remodeling) in mammalian cells and in a phytopathogenic fungus are also introduced...
  22. pmc Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    Masaaki Komatsu
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 169:425-34. 2005
    ..autophagosome formation, amino acid supply in neonates, and starvation-induced bulk degradation of proteins and organelles in mice...
  23. ncbi The biogenesis and functions of exosomes
    Willem Stoorvogel
    Department of Cell Biology, Institute of Biomembranes and Centre for Biomedical Genetics, University Medical Center Utrecht, The Netherlands
    Traffic 3:321-30. 2002
    ..Exosomes may have evolved early in the evolution of multicellular organisms and also seem to be important for tissue developmental processes...
  24. ncbi Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
    Jeremy N Timmis
    School of Molecular and Biomedical Science, The University of Adelaide, South Australia 5005, Australia
    Nat Rev Genet 5:123-35. 2004
  25. ncbi Imaging lipid bodies in cells and tissues using third-harmonic generation microscopy
    Delphine Debarre
    Laboratory for Optics and Biosciences, Ecole Polytechnique, CNRS, INSERM, F 91128 Palaiseau, France
    Nat Methods 3:47-53. 2006
    ....
  26. doi Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa
    Louis Hermo
    Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2
    Microsc Res Tech 73:279-319. 2010
    ..During spermiogenesis, many genes/proteins have been implicated in the diverse dynamic events occurring at this time of development of germ cells and the absence of some of these have been shown to result in subfertility or infertility...
  27. ncbi Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic
    Rene Bartz
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    J Lipid Res 48:837-47. 2007
    ..These results suggest that droplets play a central role in ether lipid metabolism and intracellular lipid traffic...
  28. doi Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics
    Erica L Dahl
    Department of Medicine, Division of Infectious Disease, Box 0811, University of California, San Francisco, San Francisco, CA 94143, USA
    Trends Parasitol 24:279-84. 2008
    ..Interestingly, the antibiotics thiostrepton and rifampin are fast acting and might target additional processes outside the apicoplast...
  29. doi The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes
    Rachel E Schneider
    Department of Microbiology, Immunology and Molecular Genetics David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Int J Parasitol 41:1421-34. 2011
    ..Trichomonas vaginalis lacks conventional mitochondria and instead contains divergent mitochondrial-related organelles. These double-membrane bound organelles, called hydrogenosomes, produce molecular hydrogen...
  30. pmc The protein shells of bacterial microcompartment organelles
    Todd O Yeates
    UCLA Department of Chemistry and Biochemistry, Los Angeles, CA, USA
    Curr Opin Struct Biol 21:223-31. 2011
    ..structure and function of a remarkable class of capsid-like protein assemblies that serve as simple metabolic organelles in many bacteria...
  31. doi Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
    Sara Al Rawi
    Universite Pierre et Marie Curie Paris VI, UMR7622 Biologie du Developpement, 9 Quai St Bernard, Paris, France
    Science 334:1144-7. 2011
    ..reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized...
  32. pmc Conserving a volatile metabolite: a role for carboxysome-like organelles in Salmonella enterica
    Joseph T Penrod
    Microbiology Section, Division of Biological Sciences, University of California Davis, Davis, CA, USA
    J Bacteriol 188:2865-74. 2006
    ..We propose that carboxysome-like organelles help bacteria conserve certain volatile metabolites-CO(2) or acetaldehyde-perhaps by providing a low-pH ..
  33. pmc Leukocyte lipid bodies - Biogenesis and functions in inflammation
    Patricia T Bozza
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Av Brasil, 4365, Manguinhos, 21045 900, Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1791:540-51. 2009
    ..related to the biogenesis and structure of leukocyte lipid bodies (also known as lipid droplets) as inflammatory organelles. Studies of leukocyte lipid bodies are providing functional, ultrastructural and protein compositional evidences ..
  34. pmc CK1 activates minus-end-directed transport of membrane organelles along microtubules
    Kazuho Ikeda
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Biol Cell 22:1321-9. 2011
    ....
  35. ncbi Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?
    Corinne Mercier
    Institut Jean Roget, Universite Joseph Fourier, CNRS UMR 5163, Place du Commandant Nal, 38700 La Tronche, France
    Int J Parasitol 35:829-49. 2005
    Together with micronemes and rhoptries, dense granules are specialised secretory organelles of Apicomplexa parasites...
  36. ncbi The lipid droplet is an important organelle for hepatitis C virus production
    Yusuke Miyanari
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Nat Cell Biol 9:1089-97. 2007
    ..It dynamically moves through the cytoplasm, interacting with other organelles, including the endoplasmic reticulum (ER)...
  37. pmc Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole
    S Hakansson
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 S Euclid Avenue, St Louis, MO 63110, USA
    EMBO J 20:3132-44. 2001
    Rapid discharge of secretory organelles called rhoptries is tightly coupled with host cell entry by the protozoan parasite Toxoplasma gondii...
  38. doi Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    Katherine A Mattos
    Laboratórios de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    J Leukoc Biol 87:371-84. 2010
    ....
  39. ncbi The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation
    H Lin
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 120:947-56. 1994
    ..Our results imply that Drosophila fusomes are required for ovarian cyst formation and suggest that membrane skeletal proteins regulate cystocyte divisions...
  40. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  41. ncbi Micellar nanocontainers distribute to defined cytoplasmic organelles
    Radoslav Savic
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    Science 300:615-8. 2003
    ..Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus...
  42. ncbi Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles
    E Delannoy
    ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, WA, Australia
    Biochem Soc Trans 35:1643-7. 2007
    PPR (pentatricopeptide repeat) genes form a large family particularly prevalent in higher plants and targeted to organelles. They are involved in many post-transcriptional processes such as splicing, editing, processing and translation...
  43. pmc Structure and distribution of organelles and cellular location of calcium transporters in Neurospora crassa
    Barry J Bowman
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Eukaryot Cell 8:1845-55. 2009
    ..However, the structure and distribution of organelles in live hyphae of N. crassa have not been comprehensively described...
  44. doi Adenine nucleotide transporters in organelles: novel genes and functions
    Javier Traba
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa UAM CSIC, CIBER de Enfermedades Raras, Universidad Autonoma de Madrid, Madrid, Spain
    Cell Mol Life Sci 68:1183-206. 2011
    ..This work reviews the carriers that transport adenine nucleotides into the organelles of eukaryotic cells together with their possible functions...
  45. pmc Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments
    Jana Mazelova
    Department of Surgery, Division of Ophthalmology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Cell Sci 122:2003-13. 2009
    The biogenesis of cilia-derived sensory organelles, the photoreceptor rod outer segments (ROS), is mediated by rhodopsin transport carriers (RTCs)...
  46. pmc Gene transfer from organelles to the nucleus: frequent and in big chunks
    William Martin
    Institute of Botany III, Universitat Dusseldorf, Universitatstrasse 1, D 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 100:8612-4. 2003
  47. ncbi Morphology and molecular phylogeny of Trimyema koreanum n. sp., a ciliate from the hypersaline water of a solar saltern
    Byung Cheol Cho
    School of Earth and Environmental Sciences, Seoul National University, Seoul 151 742, Korea
    J Eukaryot Microbiol 55:417-26. 2008
    ..Trimyema koreanum is able to consume both prokaryotes and small eukaryotes (specifically, the alga Dunaliella sp.)...
  48. ncbi Chromatoid bodies: aggresome-like characteristics and degradation sites for organelles of spermiogenic cells
    Celina M Haraguchi
    Biology Laboratory, University of Yamanashi, Yamanashi, Japan
    J Histochem Cytochem 53:455-65. 2005
    ..These results show that the CBs have some aggresomal features, suggesting that they are not a synthetic site as proposed previously but a degradation site where unnecessary DNA, RNA, and proteins are digested...
  49. pmc Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control
    Yuji Miyamoto
    Cancer Medicine and Biophysics Division, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 6:e16054. 2011
    ..without destroying the mitochondrial structure (designated MALM, for Mieap-induced accumulation of lysosome-like organelles within mitochondria) in response to mitochondrial damage. MALM was not related to canonical autophagy...
  50. doi RNA editing in plant organelles. Why make it easy?
    B Castandet
    Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR5234 CNRS Université Victor Segalen Bordeaux2, Bordeaux, Cedex 33076, France
    Biochemistry (Mosc) 76:924-31. 2011
    Gene expression in plant organelles involves a number of distinct co- or posttranscriptional nucleic acid modifications: 5' and 3' RNA processing, cis- and trans-splicing, RNA stability, and RNA editing...
  51. pmc Structural insight into the mechanisms of transport across the Salmonella enterica Pdu microcompartment shell
    Christopher S Crowley
    Molecular Biology Institute, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 285:37838-46. 2010
    Bacterial microcompartments are a functionally diverse group of proteinaceous organelles that confine specific reaction pathways in the cell within a thin protein-based shell...
  52. doi Carboxysomes: cyanobacterial RubisCO comes in small packages
    George S Espie
    Department of Cell and Systems Biology, University of Toronto, Mississauga, ON, Canada
    Photosynth Res 109:7-20. 2011
    ..In this review, we summarize recent advances in understanding the organization and functioning of these intriguing, and ecologically very important molecular machines...
  53. doi Polymeric vesicles: from drug carriers to nanoreactors and artificial organelles
    Pascal Tanner
    Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH 4056 Basel, Switzerland
    Acc Chem Res 44:1039-49. 2011
    ..from simple polymeric carriers to smart-complex protein-polymer assemblies, such as nanoreactors or synthetic organelles. Polymeric vesicles generated by the self-assembly of amphiphilic copolymers (polymersomes) offer the advantage ..
  54. ncbi A new polymorphic methanogen, closely related to Methanocorpusculum parvum, living in stable symbiosis within the anaerobic ciliate Trimyema sp
    B J Finlay
    Institute of Freshwater Ecology, Windermere Laboratory, Ambleside, Cumbria, UK
    J Gen Microbiol 139:371-8. 1993
    ..The symbionts belong to a new species of archaeobacterium which is a close relative of the free-living methanogen Methanocorpusculum parvum...
  55. pmc Bacterial microcompartments: their properties and paradoxes
    Shouqiang Cheng
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA
    Bioessays 30:1084-95. 2008
    Many bacteria conditionally express proteinaceous organelles referred to here as microcompartments (Fig. 1). These microcompartments are thought to be involved in a least seven different metabolic processes and the number is growing...
  56. pmc Myosin XI-K Is required for rapid trafficking of Golgi stacks, peroxisomes, and mitochondria in leaf cells of Nicotiana benthamiana
    Dror Avisar
    Department of Botany and Plant Pathology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331, USA
    Plant Physiol 146:1098-108. 2008
    A prominent feature of plant cells is the rapid, incessant movement of the organelles traditionally defined as cytoplasmic streaming and attributed to actomyosin motility...
  57. pmc Flavodiiron protein from Trichomonas vaginalis hydrogenosomes: the terminal oxygen reductase
    Tamara Smutná
    Department of Parasitology, Charles University, Vinicna, Prague, Czech Republic
    Eukaryot Cell 8:47-55. 2009
    ..is equipped with a hydrogenosomal targeting sequence and is expressed in the hydrogenosomes, oxygen-sensitive organelles that participate in carbohydrate metabolism and assemble iron-sulfur clusters...
  58. ncbi Lipoxygenase-dependent degradation of storage lipids
    I Feussner
    Dept Molecular Cell Biology, Institute of Plant Genetics and Crop Plant Research, D 06466, Corrensstr 3, Gatersleben, Germany
    Trends Plant Sci 6:268-73. 2001
    ..The free hydroperoxy fatty acids are subsequently reduced to their hydroxy derivatives, which might in turn undergo beta-oxidation...
  59. pmc Death receptor ligation triggers membrane scrambling between Golgi and mitochondria
    S Ouasti
    Faculty of Life Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester, UK
    Cell Death Differ 14:453-61. 2007
    Subcellular organelles such as mitochondria, endoplasmic reticulum (ER) and the Golgi complex are involved in the progression of the cell death programme...
  60. pmc Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes
    Roberto Docampo
    Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, GA 30602, USA
    Philos Trans R Soc Lond B Biol Sci 365:775-84. 2010
    Acidocalcisomes are acidic electron-dense organelles, rich in polyphosphate (poly P) complexed with calcium and other cations...
  61. doi Fungal evo-devo: organelles and multicellular complexity
    Gregory Jedd
    Temasek Life Sciences Laboratory and Department of Biological Sciences, The National University of Singapore, Singapore 117604
    Trends Cell Biol 21:12-9. 2011
    ..phyla, and the endoplasmic reticulum (ER)-derived septal pore cap (SPC) of the Basidiomycota, are both fungal organelles that prevent cytoplasmic bleeding when multicellular hyphal filaments are wounded...
  62. ncbi Acidocalcisomes - conserved from bacteria to man
    Roberto Docampo
    Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, Georgia 30602, USA
    Nat Rev Microbiol 3:251-61. 2005
    Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles rich in calcium and polyphosphate, are the only organelles that have been conserved during evolution from prokaryotes to eukaryotes...
  63. ncbi Rosella: a fluorescent pH-biosensor for reporting vacuolar turnover of cytosol and organelles in yeast
    Carlos J Rosado
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, Australia
    Autophagy 4:205-13. 2008
    ..We further demonstrated the value of the biosensor as a reporter of autophagy by employing fluorescence-activated cell sorting of discrete populations of cells undergoing autophagy...
  64. pmc TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP
    Michael X Zhu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH, USA
    FEBS Lett 584:1966-74. 2010
    ..With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled...
  65. pmc In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii
    Zhongqiang Chen
    Department of Biology, Penn Genomic Frontiers Institute, and the Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e3611. 2008
    ..including the human pathogens Toxoplasma gondii and Plasmodium falciparum, employ specialized secretory organelles (micronemes, rhoptries, dense granules) to invade and survive within host cells...
  66. ncbi RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function
    F Schmitz
    Howard Hughes Medical Institute, Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 28:857-72. 2000
    ..Our results define a unique component of synaptic ribbons and suggest that RIBEYE evolved in vertebrates under utilization of a preexisting protein to build a unique scaffold for a specialized synapse...
  67. ncbi Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae
    Kasinath Kuravi
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, PO Box 14, NL 9750 AA Haren, The Netherlands
    J Cell Sci 119:3994-4001. 2006
    ..This organelle divided at a very late stage of the budding process, possibly during cytokinesis...
  68. ncbi Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis
    John J Lemasters
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 27599 7090, USA
    Gastroenterology 129:351-60. 2005
    ..on cell death has grown enormously in size and complexity, a pattern has emerged that each of several distinct organelles (plasma membrane, mitochondrion, nucleus, endoplasmic reticulum, lysosome) gives rise to signals that induce ..
  69. ncbi A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
    H Lin
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 124:2463-76. 1997
    ..We have also identified a second and novel gene, piwi, whose mutations abolish germline stem cell division...
  70. ncbi Complementation of a Toxoplasma gondii ROP1 knock-out mutant using phleomycin selection
    D Soldati
    Department of Microbiology and Immonology, Stanford University School of Medicine, CA 94305 5402, USA
    Mol Biochem Parasitol 74:87-97. 1995
    ..These results demonstrate the utility of the reverse genetic approach in the study of Toxoplasma gene function and provide a further selectable marker for such manipulations...
  71. ncbi Characterization of isolated acidocalcisomes of Trypanosoma cruzi
    D A Scott
    Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    J Biol Chem 275:24215-21. 2000
    ..Assays for other organelles generally indicated no enrichment in the acidocalcisome fraction; glycosomes were concentrated 5-fold...
  72. ncbi Autophagy and vacuole homeostasis: a case for self-degradation?
    Dalibor Mijaljica
    Department of Biochemistry and Molecular Biology, and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton Campus, Victoria, Australia
    Autophagy 3:417-21. 2007
    ..of the vacuole, especially during nutrient deprivation, is the degradation of proteins, other macromolecules and organelles. To deliver these components into the vacuolar lumen, specific and sophisticated transport pathways such as ..
  73. pmc Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains
    E M Espreafico
    Department of Biology, Yale University, New Haven, Connecticut 06511
    J Cell Biol 119:1541-57. 1992
    ..Immunolocalization of myosin-V in brain and in cultured cells revealed an unusual distribution for this myosin in both neurons and nonneuronal cells.(ABSTRACT TRUNCATED AT 400 WORDS)..
  74. pmc Truncated myosin XI tail fusions inhibit peroxisome, Golgi, and mitochondrial movement in tobacco leaf epidermal cells: a genetic tool for the next generation
    Imogen A Sparkes
    School of Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK
    J Exp Bot 59:2499-512. 2008
    ..terminal YFP fusions to XIE-T and XIK-T are dispersed throughout the cytosol and do not completely decorate the organelles whose motility they affect...
  75. pmc Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events
    D C Ko
    Departments of Developmental Biology and Genetics, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 12:601-14. 2001
    ..We find that organelles containing functional NPC1-fluorescent protein fusions undergo dramatic movements, some in association with ..
  76. doi Cell division ring, a new cell division protein and vertical inheritance of a bacterial organelle in anammox planctomycetes
    Laura van Niftrik
    Department of Microbiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Microbiol 73:1009-19. 2009
    ..Electron tomography also revealed that the bacterial organelle was elongated along with the rest of the cell and divided equally among daughter cells during the cell division process...
  77. doi Seipin, adipogenesis and lipid droplets
    Weihua Fei
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Trends Endocrinol Metab 22:204-10. 2011
    ..These changes could lead to tissue-specific abnormalities upon seipin dysfunction, such as defective adipocyte development and clustered LDs in fibroblasts...
  78. ncbi Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
    B Trinczek
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, D 22607 Hamburg, Germany
    J Cell Sci 112:2355-67. 1999
    ....
  79. pmc Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication
    Winsome Cheung
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Virol 84:6782-98. 2010
    ..Rotaviruses represent a genus of another virus family utilizing LD components for replication, pointing at novel therapeutic targets for these pathogens...
  80. pmc Bacterial microcompartment organelles: protein shell structure and evolution
    Todd O Yeates
    Department of Chemistry and Biochemistry, Institute of Genomics and Proteomics, University of California, Los Angeles, California 90095, USA
    Annu Rev Biophys 39:185-205. 2010
    Some bacteria contain organelles or microcompartments consisting of a large virion-like protein shell encapsulating sequentially acting enzymes...
  81. doi Tunneling nanotube (TNT)-like structures facilitate a constitutive, actomyosin-dependent exchange of endocytic organelles between normal rat kidney cells
    Steffen Gurke
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Exp Cell Res 314:3669-83. 2008
    ..intercellular membranous bridges that mediate the transfer of various cellular components including endocytic organelles. To gain further insight into the magnitude and mechanism of organelle transfer, we performed quantitative ..
  82. ncbi MAHRP-1, a novel Plasmodium falciparum histidine-rich protein, binds ferriprotoporphyrin IX and localizes to the Maurer's clefts
    Cornelia Spycher
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 51, CH 4051 Basel, Switzerland
    J Biol Chem 278:35373-83. 2003
    ..falciparum erythrocyte membrane protein-1...
  83. pmc Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii
    Sethu C Nair
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Exp Med 208:1547-59. 2011
    ..We propose that the varied extent of metabolite exchange between host and parasite is a crucial determinator of drug susceptibility and a predictor of future resistance...
  84. ncbi An overview of endosymbiotic models for the origins of eukaryotes, their ATP-producing organelles (mitochondria and hydrogenosomes), and their heterotrophic lifestyle
    W Martin
    , , Germany
    Biol Chem 382:1521-39. 2001
    ..processes underlying the differentness of prokaryotic and eukaryotic cells and the origin of the latter's organelles are still poorly understood...
  85. ncbi The lipid-droplet proteome reveals that droplets are a protein-storage depot
    Silvia Cermelli
    Department of Developmental and Cell Biology, 2222 Natural Sciences I, University of California, Irvine, Irvine, California 92697, USA
    Curr Biol 16:1783-95. 2006
    Lipid droplets are ubiquitous organelles that are among the basic building blocks of eukaryotic cells. Despite central roles for cholesterol homeostasis and lipid metabolism, their function and protein composition are poorly understood.
  86. doi DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging
    Pierre Boesch
    Institute for Ageing and Health, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Biochim Biophys Acta 1813:186-200. 2011
    ..and exogenous physical and chemical sources generate deoxyribonucleic acid (DNA) damage in the nucleus and organelles of living cells. To prevent deleterious effects, damage is balanced by repair pathways...
  87. doi Bacterial microcompartments
    Cheryl A Kerfeld
    U S Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Annu Rev Microbiol 64:391-408. 2010
    Bacterial microcompartments (BMCs) are organelles composed entirely of protein...
  88. doi Fat on the move: intracellular motion of lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Biochem Soc Trans 37:991-6. 2009
    Lipid droplets are intracellular organelles that play central roles in lipid metabolism. In many cells, lipid droplets undergo active motion, typically along microtubules...
  89. doi Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts
    Chris Carrie
    Australian Research Council Centre of Excellence in Plant Energy Biology, M316, University of Western Australia, Crawley, Australia
    FEBS J 276:1187-95. 2009
    ..This minireview summarizes dual targeting in terms of signals, passenger proteins, receptors, regulation, why proteins may need to be dual targeted and the future challenges that remain in this area...
  90. doi CdTe nanoparticles display tropism to core histones and histone-rich cell organelles
    Jennifer Conroy
    Department of Clinical Medicine, Trinity College Dublin, Dublin 2, Ireland
    Small 4:2006-15. 2008
    ..These findings strongly suggest that charge-mediated QD/histone interactions could provide the basis for QD nuclear localization downstream of intracellular transport mechanisms...
  91. ncbi Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
    Nadia F Lamour
    Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Lipid Res 48:1293-304. 2007
    ..In conclusion, these results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT...
  92. pmc Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
    Weihua Fei
    Department of Biochemistry, National University of Singapore, Singapore 117597, Republic of Singapore
    J Cell Biol 180:473-82. 2008
    Lipid droplets (LDs) are emerging cellular organelles that are of crucial importance in cell biology and human diseases...
  93. ncbi Hydrogenosomes, mitochondria and early eukaryotic evolution
    T Martin Embley
    Department of Zoology, The Natural History Museum, London, SW7 5BD, UK
    IUBMB Life 55:387-95. 2003
    Available data suggest that unusual organelles called hydrogenosomes, that make ATP and hydrogen, and which are found in diverse anaerobic eukaryotes, were once mitochondria...
  94. pmc Proteomics in Trypanosoma cruzi--localization of novel proteins to various organelles
    Marcela Ferella
    Department of Cell and Molecular Biology CMB, Karolinska Institutet, Stockholm, Sweden
    Proteomics 8:2735-49. 2008
    ..The results demonstrate that the use of enriched subcellular fractions allows the detection of T. cruzi proteins that are undetected by whole cell proteomic methods...
  95. pmc Mitosomes in Entamoeba histolytica contain a sulfate activation pathway
    Fumika Mi-ichi
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Proc Natl Acad Sci U S A 106:21731-6. 2009
    Hydrogenosomes and mitosomes are mitochondrion-related organelles in anaerobic/microaerophilic eukaryotes with highly reduced and divergent functions...
  96. pmc Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics
    Marjan Huizing
    Cell Biology of Metabolic Disorders Unit, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Genomics Hum Genet 9:359-86. 2008
    Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share various features with lysosomes, but are distinct in function, morphology, and composition...
  97. pmc Systematic analysis of Arabidopsis organelles and a protein localization database for facilitating fluorescent tagging of full-length Arabidopsis proteins
    Shijun Li
    Department of Plant Biology, Carnegie Institution, Stanford, California 94305, USA
    Plant Physiol 141:527-39. 2006
    ..The database can be searched, browsed, and downloaded using a Web browser at http://aztec.stanford.edu/gfp/. The software can also be downloaded from the same Web site for local installation...
  98. pmc Reductive evolution of the mitochondrial processing peptidases of the unicellular parasites trichomonas vaginalis and giardia intestinalis
    Ondrej Smid
    Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    PLoS Pathog 4:e1000243. 2008
    ..The unique monomeric structure of the Giardia enzyme, and the co-evolving properties of the Giardia enzyme and substrate, provide a compelling example of the power of reductive evolution to shape parasite biology...
  99. ncbi The plastid-like organelle of apicomplexan parasites as drug target
    J Wiesner
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, Giessen, Germany
    Curr Pharm Des 14:855-71. 2008
    ..In vitro antimalarial activity was shown for inhibitors of peptide deformylase and the import of apicoplast-targeted proteins. Work on various other inhibitors of apicoplast-located biochemical processes is ongoing...
  100. ncbi Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I
    Ivan Hrdy
    Department of Parasitology, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
    Nature 432:618-22. 2004
    Hydrogenosomes are double-membraned ATP-producing and hydrogen-producing organelles of diverse anaerobic eukaryotes...
  101. ncbi Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants
    Elke Vermassen
    Laboratorium voor Fysiologie, K U Leuven, Campus Gasthuisberg O N, B 3000 Leuven, Belgium
    Biol Cell 96:3-17. 2004
    ..This indicates that the cell must be able to regulate not only IP3R expression but also its distribution. The various proteins potentially determining IP3R localization and redistribution will therefore be discussed...

Research Grants92

  1. Oocyte polarity and mRNA localization in Zebrafish
    FLORENCE LOUISE MARLOW; Fiscal Year: 2010
    ..the earliest indicator of cell polarity is an asymmetric aggregate, known as the Balbiani body, that includes organelles, proteins, and, in some animals, mRNAs encoding germline determinants...
  2. REGULATION OF GLYCOSOMAL BIOGENESIS IN T. BRUCEI
    C Wang; Fiscal Year: 1993
    Glycosomes, the membrane-bound microbody organelles in the bloodstream form of Trypanosoma brucei, contain seven glycolytic enzymes and two glycerol metabolizing enzymes...
  3. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2007
    ..Motile forms of these organelles are capable of propelling some cells like sperm and protozoa through a liquid environment while other cells like ..
  4. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..Motile forms of these organelles are capable of propelling some cells like sperm and protozoa through a liquid environment while other cells like ..
  5. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
    ..cell and molecular biology of cilia and flagella have led to an increase in not only basic research on these organelles, but clinical research related to the role of cilia and flagella in certain diseases...
  6. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2010
    ..digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen...
  7. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok Saluja; Fiscal Year: 2009
    ..digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen...
  8. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2010
    ..Recent studies indicate that NAADP mobilizes Ca2+ from lysosome-related acidic organelles;however, the molecular identity of the Ca2+ release channels and the specific internal stores involved in NAADP-..
  9. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2010
    ..digestive enzymes co-localize with lysosomal enzymes, following which lysosomal cathepsin B in the co-localized organelles activates trypsinogen...
  10. Hermansky Pudlak Syndrome & melanosome formation
    GRACA GRACA RAPOSO; Fiscal Year: 2010
    Melanosomes are tissue-specific intracellular organelles that function in the biosynthesis, storage, and transport of melanins in pigment cells of the eye and skin melanocytes...
  11. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
    ..need to be delivered intracellularly to exert their therapeutic action within the cytoplasm or specific organelles, such as nuclei, lysosomes, or mitochondria...
  12. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir P Torchilin; Fiscal Year: 2010
    ..need to be delivered intracellularly to exert their therapeutic action within the cytoplasm or specific organelles, such as nuclei, lysosomes, or mitochondria...
  13. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
    ..need to be delivered intracellularly to exert their therapeutic action within the cytoplasm or specific organelles, such as nuclei, lysosomes, or mitochondria...
  14. Autophagy in Antiviral Immunity
    Akiko Iwasaki; Fiscal Year: 2010
    ..evolutionarily conserved pathway designed to maintain cellular homeostasis by degrading long-lived proteins and organelles in the cytosol. It is also used as a survival mechanism under starvation conditions...
  15. Role of BLOC-3 in Lysosome and Melanosome Biogenesis
    ESTEBAN DELL ANGELICA; Fiscal Year: 2007
    Melanosomes are cell-type-specific, membrane-bounded organelles in which melanin pigments are synthesized and stored...
  16. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2010
    ..We hypothesize that mitochondria function as hypoxia sensors in the cell. These organelles appear to trigger adaptive responses by initiating a signaling cascade involving an increased release of ..
  17. ON THE ROLE OF THE HPS GENE PRODUCT IN MELANOCYTES
    Raymond Boissy; Fiscal Year: 2002
    ..These characteristics result from aberrations in a specific group of cellular organelles, (i.e...
  18. MITOCHONDRIAL DYNAMICS--MORPHOLOGY/DIVISION/SEGREGATION
    Robert Jensen; Fiscal Year: 1999
    Mitochondria are dynamic organelles found in virtually all eukaryotic cells and show striking variations in their location, number and structure in different cell types...
  19. Hermansky Pudlak Syndrome & melanosome formation
    Michael Marks; Fiscal Year: 2007
    ..Syndrome (HPS) is a heritable multisystem disorder in which tissue-specific, lysosome-related subcellular organelles in certain cell types are improperly formed...
  20. MOLECULAR STRUCTURE OF CNS POSTSYNAPTIC DENSITIES
    Mary Kennedy; Fiscal Year: 1993
    ..and storage in the brain, relatively little is known about the molecular composition of the key synaptic organelles involved in transmission or about the mechanisms by which the functions of these organelles are regulated...
  21. GLOBAL CONTROL OF DIFFERENTIATION IN CAULOBACTER
    Yves V Brun; Fiscal Year: 2010
    ..The localization of proteins and organelles at the cell poles is an important component of bacterial interaction with the environment;many pathogenic ..
  22. GLOBAL CONTROL OF DIFFERENTIATION IN CAULOBACTER
    YVES BRUN; Fiscal Year: 2009
    ..The localization of proteins and organelles at the cell poles is an important component of bacterial interaction with the environment; many pathogenic ..
  23. Apoptosis and Necrosis in Pancreatitis
    Anna Gukovskaya; Fiscal Year: 2009
    ..Autophagy is an important adaptive process through which the cell degrades unneeded or defective cytoplasmic organelles. Organelles to be degraded are sequestered within double-membrane vacuoles called autophagosomes, which then ..
  24. Apoptosis and Necrosis in Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2010
    ..Autophagy is an important adaptive process through which the cell degrades unneeded or defective cytoplasmic organelles. Organelles to be degraded are sequestered within double-membrane vacuoles called autophagosomes, which then ..
  25. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2006
    Cilia and flagella are eukaryotic organelles essential for both motility and sensory transduction in animals, animals and protozoa...
  26. GENETICS OF CAENORHABDITIS ELEGANS SPERM MORPHOGENESIS
    STEVEN L HERNAULT; Fiscal Year: 2003
    When cells divide, organelles and macromolecules can be partitioned unequally between daughters...
  27. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN PFISTER; Fiscal Year: 2009
    ..Cytoplasmic dynein is the motor for microtubule-based fast transport of various membranous organelles, including mitochondria, endosomes, and viruses in the retrograde direction from the axon terminus to the cell ..
  28. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN PFISTER; Fiscal Year: 2009
    ..Cytoplasmic dynein is the motor for microtubule-based fast transport of various membranous organelles, including mitochondria, endosomes, and viruses in the retrograde direction from the axon terminus to the cell ..
  29. Regulation of motility and organelle assembly at the Pseudomonas aeruginosa pole
    Barbara I Kazmierczak; Fiscal Year: 2010
    ..Two polar surface organelles of P...